Previous module | Next module Module #425, TG: 2.2, TC: 1.6, 121 probes, 121 Entrez genes, 17 conditions

Help | Hide | Top Expression data


Expression data for module #425

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

nerve-nerve synaptic transmission

The process of communication from a neuron to another neuron across a synapse.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

neurological system process

A organ system process carried out by any of the organs or tissues of neurological system.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

signal transmission

The process whereby a signal is released and/or conveyed from one location to another.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

synaptic transmission, glutamatergic

The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

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NA

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

voltage-gated calcium channel complex

A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.

dendrite

A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

calcium channel complex

An ion channel complex through which calcium ions pass.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

neuron projection

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

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NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

voltage-gated calcium channel complex

A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential.

Help | Hide | Top The GO tree — Molecular Function

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

voltage-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.

voltage-gated calcium channel activity

Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

calcium channel activity

Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

voltage-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

voltage-gated cation channel activity

Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

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NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

voltage-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.

voltage-gated cation channel activity

Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.

voltage-gated calcium channel activity

Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04730 2.554e-02 0.7238 5
30 Long-term depression

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABCG4ATP-binding cassette, sub-family G (WHITE), member 4 (ENSG00000172350), score: 0.55 ADAM22ADAM metallopeptidase domain 22 (ENSG00000008277), score: 0.6 AKAP13A kinase (PRKA) anchor protein 13 (ENSG00000170776), score: -0.59 ARPC2actin related protein 2/3 complex, subunit 2, 34kDa (ENSG00000163466), score: -0.58 BICD1bicaudal D homolog 1 (Drosophila) (ENSG00000151746), score: 0.6 BPTFbromodomain PHD finger transcription factor (ENSG00000171634), score: 0.59 BTBD3BTB (POZ) domain containing 3 (ENSG00000132640), score: 0.57 C15orf27chromosome 15 open reading frame 27 (ENSG00000169758), score: 0.67 C6orf115chromosome 6 open reading frame 115 (ENSG00000146386), score: -0.66 C7orf16chromosome 7 open reading frame 16 (ENSG00000106341), score: 0.64 C8orf79chromosome 8 open reading frame 79 (ENSG00000170941), score: 0.75 CA10carbonic anhydrase X (ENSG00000154975), score: 0.6 CA8carbonic anhydrase VIII (ENSG00000178538), score: 0.76 CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit (ENSG00000006283), score: 0.57 CACNA1Icalcium channel, voltage-dependent, T type, alpha 1I subunit (ENSG00000100346), score: 0.55 CACNB4calcium channel, voltage-dependent, beta 4 subunit (ENSG00000182389), score: 0.57 CACNG2calcium channel, voltage-dependent, gamma subunit 2 (ENSG00000166862), score: 0.55 CAMKK2calcium/calmodulin-dependent protein kinase kinase 2, beta (ENSG00000110931), score: 0.56 CBLN1cerebellin 1 precursor (ENSG00000102924), score: 0.85 CCDC109Acoiled-coil domain containing 109A (ENSG00000156026), score: 0.55 CDH7cadherin 7, type 2 (ENSG00000081138), score: 0.73 CDONCdon homolog (mouse) (ENSG00000064309), score: 0.54 CDR2Lcerebellar degeneration-related protein 2-like (ENSG00000109089), score: 0.56 CERKLceramide kinase-like (ENSG00000188452), score: 0.56 CHGBchromogranin B (secretogranin 1) (ENSG00000089199), score: 0.62 CHN2chimerin (chimaerin) 2 (ENSG00000106069), score: 0.65 CHRNA3cholinergic receptor, nicotinic, alpha 3 (ENSG00000080644), score: 0.7 CLVS2clavesin 2 (ENSG00000146352), score: 0.6 CNOT2CCR4-NOT transcription complex, subunit 2 (ENSG00000111596), score: 0.56 CNR1cannabinoid receptor 1 (brain) (ENSG00000118432), score: 0.56 CNTN6contactin 6 (ENSG00000134115), score: 0.64 CNTNAP1contactin associated protein 1 (ENSG00000108797), score: 0.54 CRHR1corticotropin releasing hormone receptor 1 (ENSG00000120088), score: 0.62 CRTAMcytotoxic and regulatory T cell molecule (ENSG00000109943), score: 0.83 DNM3dynamin 3 (ENSG00000197959), score: 0.58 DOPEY2dopey family member 2 (ENSG00000142197), score: 0.56 EBF1early B-cell factor 1 (ENSG00000164330), score: 0.56 ECE2endothelin converting enzyme 2 (ENSG00000145194), score: 0.58 EPB41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) (ENSG00000159023), score: 0.54 EPC1enhancer of polycomb homolog 1 (Drosophila) (ENSG00000120616), score: 0.65 EPHA8EPH receptor A8 (ENSG00000070886), score: 0.6 FAM131Bfamily with sequence similarity 131, member B (ENSG00000159784), score: 0.54 FAT2FAT tumor suppressor homolog 2 (Drosophila) (ENSG00000086570), score: 1 FGF5fibroblast growth factor 5 (ENSG00000138675), score: 0.75 FGFR1fibroblast growth factor receptor 1 (ENSG00000077782), score: 0.56 FKBP5FK506 binding protein 5 (ENSG00000096060), score: -0.6 FLT3fms-related tyrosine kinase 3 (ENSG00000122025), score: 0.66 FZD7frizzled homolog 7 (Drosophila) (ENSG00000155760), score: 0.62 GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 2 (ENSG00000145864), score: 0.54 GALNT7UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7) (ENSG00000109586), score: 0.63 GNG13guanine nucleotide binding protein (G protein), gamma 13 (ENSG00000127588), score: 0.73 GRIA4glutamate receptor, ionotrophic, AMPA 4 (ENSG00000152578), score: 0.65 GRID2glutamate receptor, ionotropic, delta 2 (ENSG00000152208), score: 0.81 GRM1glutamate receptor, metabotropic 1 (ENSG00000152822), score: 0.71 KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) (ENSG00000111262), score: 0.62 KCNC1potassium voltage-gated channel, Shaw-related subfamily, member 1 (ENSG00000129159), score: 0.68 KCNK10potassium channel, subfamily K, member 10 (ENSG00000100433), score: 0.7 KCNK9potassium channel, subfamily K, member 9 (ENSG00000169427), score: 0.78 KIAA0240KIAA0240 (ENSG00000112624), score: 0.57 LDB2LIM domain binding 2 (ENSG00000169744), score: -0.59 LGI2leucine-rich repeat LGI family, member 2 (ENSG00000153012), score: 0.56 LOC100131509similar to inward rectifying K+ channel negative regulator Kir2.2v (ENSG00000184185), score: 0.57 LRCH1leucine-rich repeats and calponin homology (CH) domain containing 1 (ENSG00000136141), score: 0.63 LRRC26leucine rich repeat containing 26 (ENSG00000184709), score: 0.56 LRRC38leucine rich repeat containing 38 (ENSG00000162494), score: 0.62 LRRC3Bleucine rich repeat containing 3B (ENSG00000179796), score: 0.54 MAB21L1mab-21-like 1 (C. elegans) (ENSG00000180660), score: 0.99 MAML3mastermind-like 3 (Drosophila) (ENSG00000196782), score: 0.75 MAN2A1mannosidase, alpha, class 2A, member 1 (ENSG00000112893), score: -0.59 MDGA1MAM domain containing glycosylphosphatidylinositol anchor 1 (ENSG00000112139), score: 0.69 MEIS1Meis homeobox 1 (ENSG00000143995), score: 0.61 MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (ENSG00000118058), score: 0.61 MYT1myelin transcription factor 1 (ENSG00000196132), score: 0.78 NKX6-3NK6 homeobox 3 (ENSG00000165066), score: 0.62 NMNAT2nicotinamide nucleotide adenylyltransferase 2 (ENSG00000157064), score: 0.54 NRG2neuregulin 2 (ENSG00000158458), score: 0.7 NRP1neuropilin 1 (ENSG00000099250), score: -0.61 PAX3paired box 3 (ENSG00000135903), score: 0.62 PAX6paired box 6 (ENSG00000007372), score: 0.83 PLCB4phospholipase C, beta 4 (ENSG00000101333), score: 0.69 PLCXD3phosphatidylinositol-specific phospholipase C, X domain containing 3 (ENSG00000182836), score: 0.55 PLD5phospholipase D family, member 5 (ENSG00000180287), score: 0.65 PSD2pleckstrin and Sec7 domain containing 2 (ENSG00000146005), score: 0.55 PTCH1patched 1 (ENSG00000185920), score: 0.69 PTCHD1patched domain containing 1 (ENSG00000165186), score: 0.72 PTPRRprotein tyrosine phosphatase, receptor type, R (ENSG00000153233), score: 0.61 PVALBparvalbumin (ENSG00000100362), score: 0.63 RGS8regulator of G-protein signaling 8 (ENSG00000135824), score: 0.7 RIT2Ras-like without CAAX 2 (ENSG00000152214), score: 0.61 RNF182ring finger protein 182 (ENSG00000180537), score: 0.57 SBK1SH3-binding domain kinase 1 (ENSG00000188322), score: 0.54 SEL1L3sel-1 suppressor of lin-12-like 3 (C. elegans) (ENSG00000091490), score: 0.59 SHFSrc homology 2 domain containing F (ENSG00000138606), score: 0.65 SKIv-ski sarcoma viral oncogene homolog (avian) (ENSG00000157933), score: 0.67 SKOR1SKI family transcriptional corepressor 1 (ENSG00000188779), score: 0.77 SLC35F4solute carrier family 35, member F4 (ENSG00000151812), score: 0.83 SLC6A5solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (ENSG00000165970), score: 0.73 SLC9A5solute carrier family 9 (sodium/hydrogen exchanger), member 5 (ENSG00000135740), score: 0.57 SNRKSNF related kinase (ENSG00000163788), score: 0.54 SPHKAPSPHK1 interactor, AKAP domain containing (ENSG00000153820), score: 0.64 SPINK6serine peptidase inhibitor, Kazal type 6 (ENSG00000178172), score: 0.61 SPTBN5spectrin, beta, non-erythrocytic 5 (ENSG00000137877), score: 0.54 SRRM4serine/arginine repetitive matrix 4 (ENSG00000139767), score: 0.58 SYT12synaptotagmin XII (ENSG00000173227), score: 0.54 SYT4synaptotagmin IV (ENSG00000132872), score: 0.62 TIAM1T-cell lymphoma invasion and metastasis 1 (ENSG00000156299), score: 0.75 TLL1tolloid-like 1 (ENSG00000038295), score: 0.79 TMEM63Ctransmembrane protein 63C (ENSG00000165548), score: 0.55 TNFAIP2tumor necrosis factor, alpha-induced protein 2 (ENSG00000185215), score: -0.61 TP73tumor protein p73 (ENSG00000078900), score: 0.57 TRIM67tripartite motif-containing 67 (ENSG00000119283), score: 0.86 TRPC3transient receptor potential cation channel, subfamily C, member 3 (ENSG00000138741), score: 0.65 UNC80unc-80 homolog (C. elegans) (ENSG00000144406), score: 0.55 UPF0639UPF0639 protein (ENSG00000175985), score: 0.77 VAT1Lvesicle amine transport protein 1 homolog (T. californica)-like (ENSG00000171724), score: 0.61 WSCD1WSC domain containing 1 (ENSG00000179314), score: 0.55 ZFPM2zinc finger protein, multitype 2 (ENSG00000169946), score: 0.67 ZIC4Zic family member 4 (ENSG00000174963), score: 0.93 ZNF238zinc finger protein 238 (ENSG00000179456), score: 0.7 ZNF521zinc finger protein 521 (ENSG00000198795), score: 0.81 ZNF536zinc finger protein 536 (ENSG00000198597), score: 0.59

Non-Entrez genes

Unknown, score:

Help | Hide | Top Conditions

Id species tissue sex individual
mmu_cb_m1_ca1 mmu cb m 1
mmu_cb_f_ca1 mmu cb f _
oan_cb_f_ca1 oan cb f _
oan_cb_m_ca1 oan cb m _
mmu_cb_m2_ca1 mmu cb m 2
ptr_cb_f_ca1 ptr cb f _
ppa_cb_f_ca1 ppa cb f _
mdo_cb_m_ca1 mdo cb m _
mdo_cb_f_ca1 mdo cb f _
ppy_cb_f_ca1 ppy cb f _
mml_cb_f_ca1 mml cb f _
ggo_cb_f_ca1 ggo cb f _
hsa_cb_f_ca1 hsa cb f _
mml_cb_m_ca1 mml cb m _
ppa_cb_m_ca1 ppa cb m _
hsa_cb_m_ca1 hsa cb m _
ptr_cb_m_ca1 ptr cb m _

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