Previous module | Next module Module #442, TG: 2.2, TC: 1, 28 probes, 28 Entrez genes, 36 conditions

Help | Hide | Top Expression data


Expression data for module #442

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

neurological system process

A organ system process carried out by any of the organs or tissues of neurological system.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

signal transmission

The process whereby a signal is released and/or conveyed from one location to another.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

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NA

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

Help | Hide | Top The GO tree — Cellular Components

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membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

chloride channel complex

An ion channel complex through which chloride ions pass.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

synapse

The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

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cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

Help | Hide | Top The GO tree — Molecular Function

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

GABA-A receptor activity

Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

extracellular ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

GABA receptor activity

Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

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NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04080 1.591e-03 0.6767 6
102 Neuroactive ligand-receptor interaction

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

BEGAINbrain-enriched guanylate kinase-associated homolog (rat) (ENSG00000183092), score: 0.91 C12orf53chromosome 12 open reading frame 53 (ENSG00000139200), score: 0.92 C8orf46chromosome 8 open reading frame 46 (ENSG00000169085), score: 0.93 FBXL16F-box and leucine-rich repeat protein 16 (ENSG00000127585), score: 0.93 GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 3 (ENSG00000166206), score: 0.91 GABRG1gamma-aminobutyric acid (GABA) A receptor, gamma 1 (ENSG00000163285), score: 0.96 GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 2 (ENSG00000113327), score: 0.89 GPR176G protein-coupled receptor 176 (ENSG00000166073), score: 0.93 GPR83G protein-coupled receptor 83 (ENSG00000123901), score: 0.9 GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1 (ENSG00000176884), score: 0.89 HRH3histamine receptor H3 (ENSG00000101180), score: 1 KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 2 (ENSG00000075043), score: 0.98 KCNT1potassium channel, subfamily T, member 1 (ENSG00000107147), score: 0.89 MTFR1mitochondrial fission regulator 1 (ENSG00000066855), score: -0.85 MYT1Lmyelin transcription factor 1-like (ENSG00000186487), score: 0.91 NCDNneurochondrin (ENSG00000020129), score: 0.89 NDPNorrie disease (pseudoglioma) (ENSG00000124479), score: 0.89 POLR3Apolymerase (RNA) III (DNA directed) polypeptide A, 155kDa (ENSG00000148606), score: 0.91 PSDpleckstrin and Sec7 domain containing (ENSG00000059915), score: 0.9 RESTRE1-silencing transcription factor (ENSG00000084093), score: -0.88 RIMS3regulating synaptic membrane exocytosis 3 (ENSG00000117016), score: 0.94 SCRG1stimulator of chondrogenesis 1 (ENSG00000164106), score: 0.91 STMN4stathmin-like 4 (ENSG00000015592), score: 0.9 SV2Bsynaptic vesicle glycoprotein 2B (ENSG00000185518), score: 0.89 TMEM59Ltransmembrane protein 59-like (ENSG00000105696), score: 0.93 UNC5Aunc-5 homolog A (C. elegans) (ENSG00000113763), score: 0.92 ZDHHC22zinc finger, DHHC-type containing 22 (ENSG00000177108), score: 0.92 ZNF365zinc finger protein 365 (ENSG00000138311), score: 0.9

Non-Entrez genes

Unknown, score:

Help | Hide | Top Conditions

Id species tissue sex individual
ptr_cb_f_ca1 ptr cb f _
mml_cb_f_ca1 mml cb f _
mmu_cb_m1_ca1 mmu cb m 1
ggo_cb_m_ca1 ggo cb m _
ptr_cb_m_ca1 ptr cb m _
ppy_cb_f_ca1 ppy cb f _
ppa_cb_f_ca1 ppa cb f _
mml_cb_m_ca1 mml cb m _
ppa_cb_m_ca1 ppa cb m _
ggo_cb_f_ca1 ggo cb f _
hsa_cb_f_ca1 hsa cb f _
mmu_br_f_ca1 mmu br f _
ppa_br_f2_ca1 ppa br f 2
mmu_br_m2_ca1 mmu br m 2
mmu_br_m1_ca1 mmu br m 1
hsa_cb_m_ca1 hsa cb m _
ptr_br_f_ca1 ptr br f _
ppa_br_m_ca1 ppa br m _
mml_br_m1_ca1 mml br m 1
hsa_br_f_ca1 hsa br f _
hsa_br_m2_ca1 hsa br m 2
ptr_br_m4_ca1 ptr br m 4
hsa_br_m1_ca1 hsa br m 1
ptr_br_m5_ca1 ptr br m 5
ptr_br_m3_ca1 ptr br m 3
ggo_br_f_ca1 ggo br f _
ptr_br_m2_ca1 ptr br m 2
mml_br_f_ca1 mml br f _
ppy_br_f_ca1 ppy br f _
ggo_br_m_ca1 ggo br m _
ppa_br_f1_ca1 ppa br f 1
mml_br_m2_ca1 mml br m 2
ppy_br_m_ca1 ppy br m _
hsa_br_m3_ca1 hsa br m 3
ptr_br_m1_ca1 ptr br m 1
hsa_br_m7_ca1 hsa br m 7

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© 2008-2010 Computational Biology Group, Department of Medical Genetics, University of Lausanne, Switzerland