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Expression data for module #447

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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reproduction

The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism.

chromosome segregation

The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets.

chromosome organization

A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

reproductive developmental process

A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.

cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

DNA metabolic process

Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

DNA recombination

Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

DNA packaging

Any process by which DNA and associated proteins are formed into a compact, orderly structure.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

organelle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

microtubule-based process

Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

meiosis

A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations.

meiosis I

A cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.

reciprocal meiotic recombination

The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

gamete generation

The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.

germ cell development

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

spermatogenesis

The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular component organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.

sexual reproduction

The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

reproductive process

A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

microtubule organizing center organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

multicellular organism reproduction

The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

male gamete generation

Generation of the male gamete; specialised haploid cells produced by meiosis and along with a female gamete takes part in sexual reproduction.

organelle fission

The creation of two or more organelles by division of one organelle.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

reproductive process in a multicellular organism

The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.

reproductive cellular process

A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

centrosome organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

meiotic cell cycle

Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell.

M phase of meiotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the meiotic cell cycle during which meiosis takes place.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

DNA conformation change

A cellular process that results in a change in the spatial configuration of a DNA molecule. A conformation change can bend DNA, or alter the, twist, writhe, or linking number of a DNA molecule.

nucleic acid metabolic process

Any cellular metabolic process involving nucleic acids.

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reproductive process

A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

organelle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

reproductive cellular process

A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular or single-celled organism.

multicellular organism reproduction

The biological process by which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

reproductive process in a multicellular organism

The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.

reproductive developmental process

A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

reproductive process in a multicellular organism

The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

DNA packaging

Any process by which DNA and associated proteins are formed into a compact, orderly structure.

germ cell development

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

gamete generation

The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

germ cell development

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

microtubule organizing center organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.

mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

germ cell development

The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.

DNA metabolic process

Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

meiosis

A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

spindle organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

M phase of meiotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the meiotic cell cycle during which meiosis takes place.

meiosis I

A cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.

reciprocal meiotic recombination

The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

reciprocal meiotic recombination

The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.

Help | Hide | Top The GO tree — Cellular Components

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nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensed nuclear chromosome, centromeric region

The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

microtubule organizing center

A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

Ndc80 complex

A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

P granule

A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

pole plasm

Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo.

germ plasm

Differentiated cytoplasm associated with a pole of an oocyte, egg or early embryo that will be inherited by the cells that will give rise to the germ line.

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cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

Ndc80 complex

A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

Ndc80 complex

A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

microtubule organizing center

A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

P granule

A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

condensed nuclear chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

microtubule organizing center

A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed nuclear chromosome, centromeric region

The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensed nuclear chromosome, centromeric region

The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

P granule

A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

nucleic acid binding

Interacting selectively and non-covalently with any nucleic acid.

DNA binding

Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

motor activity

Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.

microtubule motor activity

Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

nuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids.

exonuclease activity

Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

pyrophosphatase activity

Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on ester bonds

Catalysis of the hydrolysis of any ester bond.

hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride.

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.

all

NA

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Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
03440 1.743e-03 0.3914 5
11 Homologous recombination
04110 8.868e-03 1.637 8
46 Cell cycle

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Help | Hide | Top Genes

Entrez genes

ADAD1adenosine deaminase domain containing 1 (testis-specific) (ENSG00000164113), score: 0.58 AGBL3ATP/GTP binding protein-like 3 (ENSG00000146856), score: 0.74 AK7adenylate kinase 7 (ENSG00000140057), score: 0.67 AKIRIN2akirin 2 (ENSG00000135334), score: 0.61 AMHanti-Mullerian hormone (ENSG00000104899), score: 0.59 ANKRD5ankyrin repeat domain 5 (ENSG00000132623), score: 0.64 APPamyloid beta (A4) precursor protein (ENSG00000142192), score: -0.6 APTXaprataxin (ENSG00000137074), score: 0.57 ARHGAP40Rho GTPase activating protein 40 (ENSG00000124143), score: 0.6 ARID3BAT rich interactive domain 3B (BRIGHT-like) (ENSG00000179361), score: 0.63 ARMC4armadillo repeat containing 4 (ENSG00000169126), score: 0.58 ASF1AASF1 anti-silencing function 1 homolog A (S. cerevisiae) (ENSG00000111875), score: 0.7 ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila) (ENSG00000066279), score: 0.93 ATAD2ATPase family, AAA domain containing 2 (ENSG00000156802), score: 0.68 ATP9AATPase, class II, type 9A (ENSG00000054793), score: -0.52 B3GNT5UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (ENSG00000176597), score: 0.75 BICD2bicaudal D homolog 2 (Drosophila) (ENSG00000185963), score: -0.57 BLMBloom syndrome, RecQ helicase-like (ENSG00000197299), score: 0.53 BOLLbol, boule-like (Drosophila) (ENSG00000152430), score: 0.6 BRCA2breast cancer 2, early onset (ENSG00000139618), score: 0.6 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (ENSG00000169679), score: 0.54 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (ENSG00000156970), score: 0.6 C10orf58chromosome 10 open reading frame 58 (ENSG00000122378), score: -0.52 C11orf30chromosome 11 open reading frame 30 (ENSG00000158636), score: 0.56 C11orf70chromosome 11 open reading frame 70 (ENSG00000137691), score: 0.57 C12orf48chromosome 12 open reading frame 48 (ENSG00000185480), score: 0.66 C12orf50chromosome 12 open reading frame 50 (ENSG00000165805), score: 0.65 C12orf63chromosome 12 open reading frame 63 (ENSG00000188596), score: 0.6 C13orf34chromosome 13 open reading frame 34 (ENSG00000136122), score: 0.72 C14orf166Bchromosome 14 open reading frame 166B (ENSG00000100565), score: 0.53 C14orf39chromosome 14 open reading frame 39 (ENSG00000179008), score: 0.9 C14orf50chromosome 14 open reading frame 50 (ENSG00000165807), score: 0.68 C15orf26chromosome 15 open reading frame 26 (ENSG00000156206), score: 0.57 C17orf104chromosome 17 open reading frame 104 (ENSG00000180336), score: 0.61 C17orf71chromosome 17 open reading frame 71 (ENSG00000167447), score: 0.57 C19orf45chromosome 19 open reading frame 45 (ENSG00000198723), score: 0.6 C1orf100chromosome 1 open reading frame 100 (ENSG00000173728), score: 0.64 C1orf111chromosome 1 open reading frame 111 (ENSG00000171722), score: 0.69 C1orf158chromosome 1 open reading frame 158 (ENSG00000157330), score: 0.74 C1orf174chromosome 1 open reading frame 174 (ENSG00000198912), score: 0.57 C1orf228chromosome 1 open reading frame 228 (ENSG00000198520), score: 0.56 C1orf88chromosome 1 open reading frame 88 (ENSG00000173947), score: 0.62 C1orf9chromosome 1 open reading frame 9 (ENSG00000094975), score: 0.76 C20orf85chromosome 20 open reading frame 85 (ENSG00000124237), score: 0.64 C4orf47chromosome 4 open reading frame 47 (ENSG00000205129), score: 0.72 C5orf51chromosome 5 open reading frame 51 (ENSG00000205765), score: 0.69 C7orf45chromosome 7 open reading frame 45 (ENSG00000165120), score: 0.57 C7orf57chromosome 7 open reading frame 57 (ENSG00000164746), score: 0.7 C7orf60chromosome 7 open reading frame 60 (ENSG00000164603), score: 0.64 C7orf62chromosome 7 open reading frame 62 (ENSG00000164645), score: 0.59 C9orf9chromosome 9 open reading frame 9 (ENSG00000165698), score: 0.58 CAP1CAP, adenylate cyclase-associated protein 1 (yeast) (ENSG00000131236), score: -0.55 CASC1cancer susceptibility candidate 1 (ENSG00000118307), score: 0.63 CASP2caspase 2, apoptosis-related cysteine peptidase (ENSG00000106144), score: 0.57 CCDC108coiled-coil domain containing 108 (ENSG00000181378), score: 0.62 CCDC113coiled-coil domain containing 113 (ENSG00000103021), score: 0.56 CCDC122coiled-coil domain containing 122 (ENSG00000151773), score: 0.61 CCDC124coiled-coil domain containing 124 (ENSG00000007080), score: -0.59 CCDC135coiled-coil domain containing 135 (ENSG00000159625), score: 0.54 CCDC27coiled-coil domain containing 27 (ENSG00000162592), score: 0.7 CCDC37coiled-coil domain containing 37 (ENSG00000163885), score: 0.56 CCDC63coiled-coil domain containing 63 (ENSG00000173093), score: 0.58 CCDC67coiled-coil domain containing 67 (ENSG00000165325), score: 0.68 CCNA1cyclin A1 (ENSG00000133101), score: 0.62 CCNYcyclin Y (ENSG00000108100), score: -0.54 CDC42EP4CDC42 effector protein (Rho GTPase binding) 4 (ENSG00000179604), score: -0.64 CENPHcentromere protein H (ENSG00000153044), score: 0.53 CENPIcentromere protein I (ENSG00000102384), score: 0.96 CENPKcentromere protein K (ENSG00000123219), score: 0.71 CENPQcentromere protein Q (ENSG00000031691), score: 0.61 CENPTcentromere protein T (ENSG00000102901), score: 0.57 CEP55centrosomal protein 55kDa (ENSG00000138180), score: 0.55 CHAF1Bchromatin assembly factor 1, subunit B (p60) (ENSG00000159259), score: 0.68 CLSPNclaspin (ENSG00000092853), score: 0.59 CNGA2cyclic nucleotide gated channel alpha 2 (ENSG00000183862), score: 0.83 CNGB1cyclic nucleotide gated channel beta 1 (ENSG00000070729), score: 0.68 CNOT4CCR4-NOT transcription complex, subunit 4 (ENSG00000080802), score: 0.58 COL17A1collagen, type XVII, alpha 1 (ENSG00000065618), score: 0.71 COQ3coenzyme Q3 homolog, methyltransferase (S. cerevisiae) (ENSG00000132423), score: 0.55 CPA1carboxypeptidase A1 (pancreatic) (ENSG00000091704), score: 0.7 CPA6carboxypeptidase A6 (ENSG00000165078), score: 0.62 CREB3cAMP responsive element binding protein 3 (ENSG00000107175), score: -0.6 CRY2cryptochrome 2 (photolyase-like) (ENSG00000121671), score: -0.62 CRYBA1crystallin, beta A1 (ENSG00000108255), score: 0.69 CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa (ENSG00000168036), score: -0.53 CXorf22chromosome X open reading frame 22 (ENSG00000165164), score: 0.85 CXorf23chromosome X open reading frame 23 (ENSG00000173681), score: 0.61 CXorf30chromosome X open reading frame 30 (ENSG00000205081), score: 0.9 CYB5R3cytochrome b5 reductase 3 (ENSG00000100243), score: -0.57 CYP11A1cytochrome P450, family 11, subfamily A, polypeptide 1 (ENSG00000140459), score: 0.76 DCLRE1CDNA cross-link repair 1C (ENSG00000152457), score: 0.61 DDX4DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 (ENSG00000152670), score: 0.61 DHRS11dehydrogenase/reductase (SDR family) member 11 (ENSG00000108272), score: -0.52 DLG1discs, large homolog 1 (Drosophila) (ENSG00000075711), score: -0.52 DMC1DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) (ENSG00000100206), score: 0.68 DMRT3doublesex and mab-3 related transcription factor 3 (ENSG00000064218), score: 0.82 DNAH8dynein, axonemal, heavy chain 8 (ENSG00000124721), score: 0.61 DNAI1dynein, axonemal, intermediate chain 1 (ENSG00000122735), score: 0.64 DNAI2dynein, axonemal, intermediate chain 2 (ENSG00000171595), score: 0.64 DSCC1defective in sister chromatid cohesion 1 homolog (S. cerevisiae) (ENSG00000136982), score: 0.63 DTX2deltex homolog 2 (Drosophila) (ENSG00000091073), score: 0.58 DYDC1DPY30 domain containing 1 (ENSG00000170788), score: 0.59 E2F4E2F transcription factor 4, p107/p130-binding (ENSG00000205250), score: -0.54 E2F7E2F transcription factor 7 (ENSG00000165891), score: 0.57 EFCAB1EF-hand calcium binding domain 1 (ENSG00000034239), score: 0.79 EFCAB5EF-hand calcium binding domain 5 (ENSG00000176927), score: 0.66 EFHC1EF-hand domain (C-terminal) containing 1 (ENSG00000096093), score: 0.55 ENO4enolase family member 4 (ENSG00000188316), score: 0.55 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (ENSG00000186871), score: 0.93 ESYT2extended synaptotagmin-like protein 2 (ENSG00000117868), score: -0.66 EXO1exonuclease 1 (ENSG00000174371), score: 0.71 EXOSC1exosome component 1 (ENSG00000171311), score: 0.54 EXOSC10exosome component 10 (ENSG00000171824), score: 0.67 FAM194Afamily with sequence similarity 194, member A (ENSG00000163645), score: 0.59 FAM65Afamily with sequence similarity 65, member A (ENSG00000039523), score: -0.56 FAM83Dfamily with sequence similarity 83, member D (ENSG00000101447), score: 0.6 FANCBFanconi anemia, complementation group B (ENSG00000181544), score: 0.93 FBXO15F-box protein 15 (ENSG00000141665), score: 0.55 FBXO42F-box protein 42 (ENSG00000037637), score: 0.59 FBXO43F-box protein 43 (ENSG00000156509), score: 0.54 FBXO47F-box protein 47 (ENSG00000204952), score: 0.86 FOXJ1forkhead box J1 (ENSG00000129654), score: 0.57 GABPB1GA binding protein transcription factor, beta subunit 1 (ENSG00000104064), score: 0.55 GEMC1geminin coiled-coil domain-containing protein 1 (ENSG00000205835), score: 0.78 GPATCH2G patch domain containing 2 (ENSG00000092978), score: 0.77 GPR20G protein-coupled receptor 20 (ENSG00000204882), score: 0.67 GRXCR1glutaredoxin, cysteine rich 1 (ENSG00000215203), score: 0.62 HAUS2HAUS augmin-like complex, subunit 2 (ENSG00000137814), score: 0.58 HDXhighly divergent homeobox (ENSG00000165259), score: 0.58 HELLShelicase, lymphoid-specific (ENSG00000119969), score: 0.62 HMOX2heme oxygenase (decycling) 2 (ENSG00000103415), score: 0.61 HORMAD1HORMA domain containing 1 (ENSG00000143452), score: 0.76 HORMAD2HORMA domain containing 2 (ENSG00000176635), score: 0.67 IFT46intraflagellar transport 46 homolog (Chlamydomonas) (ENSG00000118096), score: 0.54 IKBIPIKBKB interacting protein (ENSG00000166130), score: 0.55 ING3inhibitor of growth family, member 3 (ENSG00000071243), score: 0.67 IQCHIQ motif containing H (ENSG00000103599), score: 0.6 IQUBIQ motif and ubiquitin domain containing (ENSG00000164675), score: 0.76 ISG20L2interferon stimulated exonuclease gene 20kDa-like 2 (ENSG00000143319), score: 0.62 ITM2Bintegral membrane protein 2B (ENSG00000136156), score: -0.57 KIAA1712KIAA1712 (ENSG00000164118), score: 0.6 KIF11kinesin family member 11 (ENSG00000138160), score: 0.68 KIF14kinesin family member 14 (ENSG00000118193), score: 0.73 KIF18Akinesin family member 18A (ENSG00000121621), score: 0.6 KIF18Bkinesin family member 18B (ENSG00000186185), score: 0.6 KIF24kinesin family member 24 (ENSG00000186638), score: 0.56 KIF2Bkinesin family member 2B (ENSG00000141200), score: 0.72 KIF6kinesin family member 6 (ENSG00000164627), score: 0.64 KIFC3kinesin family member C3 (ENSG00000140859), score: -0.54 KLF15Kruppel-like factor 15 (ENSG00000163884), score: -0.54 KLHL10kelch-like 10 (Drosophila) (ENSG00000161594), score: 0.7 LBRlamin B receptor (ENSG00000143815), score: 0.6 LCORLligand dependent nuclear receptor corepressor-like (ENSG00000178177), score: 0.69 LCTlactase (ENSG00000115850), score: 0.84 LHCGRluteinizing hormone/choriogonadotropin receptor (ENSG00000138039), score: 0.86 LIN28Blin-28 homolog B (C. elegans) (ENSG00000187772), score: 0.86 LRGUKleucine-rich repeats and guanylate kinase domain containing (ENSG00000155530), score: 0.72 LRRC18leucine rich repeat containing 18 (ENSG00000165383), score: 0.64 LRRC43leucine rich repeat containing 43 (ENSG00000158113), score: 0.69 LRRC52leucine rich repeat containing 52 (ENSG00000162763), score: 0.76 LRRC67leucine rich repeat containing 67 (ENSG00000178125), score: 0.79 LRRC8Aleucine rich repeat containing 8 family, member A (ENSG00000136802), score: -0.54 LRRIQ4leucine-rich repeats and IQ motif containing 4 (ENSG00000188306), score: 0.79 LZTFL1leucine zipper transcription factor-like 1 (ENSG00000163818), score: 0.54 MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha (ENSG00000101460), score: -0.56 MAP3K5mitogen-activated protein kinase kinase kinase 5 (ENSG00000197442), score: -0.59 MAP9microtubule-associated protein 9 (ENSG00000164114), score: 0.66 MCM5minichromosome maintenance complex component 5 (ENSG00000100297), score: 0.56 MED7mediator complex subunit 7 (ENSG00000155868), score: 0.54 MELKmaternal embryonic leucine zipper kinase (ENSG00000165304), score: 0.82 MLLT1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 (ENSG00000130382), score: -0.57 MLLT6myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 (ENSG00000108292), score: -0.65 MORN3MORN repeat containing 3 (ENSG00000139714), score: 0.53 MOV10L1Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) (ENSG00000073146), score: 0.58 MTF1metal-regulatory transcription factor 1 (ENSG00000188786), score: 0.54 MTF2metal response element binding transcription factor 2 (ENSG00000143033), score: 0.72 MTMR12myotubularin related protein 12 (ENSG00000150712), score: -0.56 MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1 (ENSG00000185697), score: 0.79 MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 2 (ENSG00000101057), score: 0.56 MYF5myogenic factor 5 (ENSG00000111049), score: 0.72 MYF6myogenic factor 6 (herculin) (ENSG00000111046), score: 0.57 MYO18Amyosin XVIIIA (ENSG00000196535), score: -0.53 NCAPGnon-SMC condensin I complex, subunit G (ENSG00000109805), score: 0.68 NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae) (ENSG00000080986), score: 0.63 NDST2N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 (ENSG00000166507), score: -0.57 NFIBnuclear factor I/B (ENSG00000147862), score: -0.55 NISCHnischarin (ENSG00000010322), score: -0.58 NPRL2nitrogen permease regulator-like 2 (S. cerevisiae) (ENSG00000114388), score: -0.64 NR5A1nuclear receptor subfamily 5, group A, member 1 (ENSG00000136931), score: 0.68 NUB1negative regulator of ubiquitin-like proteins 1 (ENSG00000013374), score: 0.55 NUF2NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) (ENSG00000143228), score: 0.63 NUFIP1nuclear fragile X mental retardation protein interacting protein 1 (ENSG00000083635), score: 0.58 ORC1Lorigin recognition complex, subunit 1-like (S. cerevisiae) (ENSG00000085840), score: 0.74 OXTRoxytocin receptor (ENSG00000180914), score: 0.66 PARNpoly(A)-specific ribonuclease (deadenylation nuclease) (ENSG00000140694), score: -0.52 PAX5paired box 5 (ENSG00000196092), score: 0.64 PAX9paired box 9 (ENSG00000198807), score: 0.63 PIH1D2PIH1 domain containing 2 (ENSG00000150773), score: 0.61 PIWIL1piwi-like 1 (Drosophila) (ENSG00000125207), score: 0.65 PNPLA6patatin-like phospholipase domain containing 6 (ENSG00000032444), score: -0.52 POC5POC5 centriolar protein homolog (Chlamydomonas) (ENSG00000152359), score: 0.58 POLD3polymerase (DNA-directed), delta 3, accessory subunit (ENSG00000077514), score: 0.65 PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha (ENSG00000109819), score: -0.53 PPEF2protein phosphatase, EF-hand calcium binding domain 2 (ENSG00000156194), score: 0.54 PPYR1pancreatic polypeptide receptor 1 (ENSG00000204174), score: 0.55 PRPF40APRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) (ENSG00000196504), score: 0.55 PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 2 (ENSG00000161057), score: 0.53 PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 (ENSG00000163636), score: -0.6 PTHLHparathyroid hormone-like hormone (ENSG00000087494), score: 0.55 QTRTD1queuine tRNA-ribosyltransferase domain containing 1 (ENSG00000151576), score: 0.62 RAD54BRAD54 homolog B (S. cerevisiae) (ENSG00000197275), score: 0.78 RAG2recombination activating gene 2 (ENSG00000175097), score: 0.58 RBM46RNA binding motif protein 46 (ENSG00000151962), score: 0.81 RBP2retinol binding protein 2, cellular (ENSG00000114113), score: 0.8 RCHY1ring finger and CHY zinc finger domain containing 1 (ENSG00000163743), score: 0.59 RFX6regulatory factor X, 6 (ENSG00000185002), score: 0.69 RIBC2RIB43A domain with coiled-coils 2 (ENSG00000128408), score: 0.68 RNF17ring finger protein 17 (ENSG00000132972), score: 0.69 RPAP2RNA polymerase II associated protein 2 (ENSG00000122484), score: 0.55 RRM1ribonucleotide reductase M1 (ENSG00000167325), score: 0.59 RSPH4Aradial spoke head 4 homolog A (Chlamydomonas) (ENSG00000111834), score: 0.57 RSPH9radial spoke head 9 homolog (Chlamydomonas) (ENSG00000172426), score: 0.6 SASS6spindle assembly 6 homolog (C. elegans) (ENSG00000156876), score: 0.57 SDC4syndecan 4 (ENSG00000124145), score: -0.58 SEPT11septin 11 (ENSG00000138758), score: -0.57 SGK1serum/glucocorticoid regulated kinase 1 (ENSG00000118515), score: -0.54 SGOL1shugoshin-like 1 (S. pombe) (ENSG00000129810), score: 0.84 SHCBP1SHC SH2-domain binding protein 1 (ENSG00000171241), score: 0.53 SLC25A29solute carrier family 25, member 29 (ENSG00000197119), score: -0.53 SLC26A8solute carrier family 26, member 8 (ENSG00000112053), score: 0.55 SLC6A14solute carrier family 6 (amino acid transporter), member 14 (ENSG00000087916), score: 0.86 SMC1Bstructural maintenance of chromosomes 1B (ENSG00000077935), score: 0.65 SNX16sorting nexin 16 (ENSG00000104497), score: 0.63 SPACA1sperm acrosome associated 1 (ENSG00000118434), score: 0.64 SPATA18spermatogenesis associated 18 homolog (rat) (ENSG00000163071), score: 0.56 SPATA4spermatogenesis associated 4 (ENSG00000150628), score: 0.54 SPATA5L1spermatogenesis associated 5-like 1 (ENSG00000171763), score: 0.6 SPATS2spermatogenesis associated, serine-rich 2 (ENSG00000123352), score: 0.64 SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) (ENSG00000152253), score: 0.78 SPO11SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae) (ENSG00000054796), score: 0.56 SPRY4sprouty homolog 4 (Drosophila) (ENSG00000187678), score: -0.6 SPTBN1spectrin, beta, non-erythrocytic 1 (ENSG00000115306), score: -0.64 SQSTM1sequestosome 1 (ENSG00000161011), score: -0.67 SRSF5serine/arginine-rich splicing factor 5 (ENSG00000100650), score: -0.6 ST6GALNAC6ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ENSG00000160408), score: -0.54 STRA8stimulated by retinoic acid gene 8 homolog (mouse) (ENSG00000146857), score: 0.94 SYCP1synaptonemal complex protein 1 (ENSG00000198765), score: 0.67 TACC1transforming, acidic coiled-coil containing protein 1 (ENSG00000147526), score: -0.54 TBC1D5TBC1 domain family, member 5 (ENSG00000131374), score: -0.54 TBX4T-box 4 (ENSG00000121075), score: 1 TDRD1tudor domain containing 1 (ENSG00000095627), score: 0.66 TDRD5tudor domain containing 5 (ENSG00000162782), score: 0.61 TDRD6tudor domain containing 6 (ENSG00000180113), score: 0.61 TEKT2tektin 2 (testicular) (ENSG00000092850), score: 0.53 TEKT3tektin 3 (ENSG00000125409), score: 0.72 TEKT5tektin 5 (ENSG00000153060), score: 0.64 TEX10testis expressed 10 (ENSG00000136891), score: 0.55 TEX9testis expressed 9 (ENSG00000151575), score: 0.53 TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (ENSG00000137203), score: 0.56 THAP11THAP domain containing 11 (ENSG00000168286), score: -0.6 TLX1T-cell leukemia homeobox 1 (ENSG00000107807), score: 0.66 TOP2Atopoisomerase (DNA) II alpha 170kDa (ENSG00000131747), score: 0.73 TP53TG5TP53 target 5 (ENSG00000124251), score: 0.6 TPRA1transmembrane protein, adipocyte asscociated 1 (ENSG00000163870), score: -0.56 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (ENSG00000088325), score: 0.63 TRIM36tripartite motif-containing 36 (ENSG00000152503), score: 0.54 TRIM71tripartite motif-containing 71 (ENSG00000206557), score: 0.6 TRPC6transient receptor potential cation channel, subfamily C, member 6 (ENSG00000137672), score: 0.79 TSGA14testis specific, 14 (ENSG00000106477), score: 0.78 TTC25tetratricopeptide repeat domain 25 (ENSG00000204815), score: 0.72 TTC27tetratricopeptide repeat domain 27 (ENSG00000018699), score: 0.54 TTKTTK protein kinase (ENSG00000112742), score: 0.68 UBE2R2ubiquitin-conjugating enzyme E2R 2 (ENSG00000107341), score: 0.56 UBE4Aubiquitination factor E4A (UFD2 homolog, yeast) (ENSG00000110344), score: 0.68 UBN2ubinuclein 2 (ENSG00000157741), score: 0.58 USP49ubiquitin specific peptidase 49 (ENSG00000164663), score: 0.59 WDHD1WD repeat and HMG-box DNA binding protein 1 (ENSG00000198554), score: 0.65 WDR16WD repeat domain 16 (ENSG00000166596), score: 0.66 WDR64WD repeat domain 64 (ENSG00000162843), score: 0.61 WDR76WD repeat domain 76 (ENSG00000092470), score: 0.66 WDR78WD repeat domain 78 (ENSG00000152763), score: 0.78 XRCC2X-ray repair complementing defective repair in Chinese hamster cells 2 (ENSG00000196584), score: 0.57 YOD1YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) (ENSG00000180667), score: 0.74 ZC3H7Bzinc finger CCCH-type containing 7B (ENSG00000100403), score: -0.65 ZDHHC7zinc finger, DHHC-type containing 7 (ENSG00000153786), score: -0.65 ZHX3zinc fingers and homeoboxes 3 (ENSG00000174306), score: -0.59 ZMYND11zinc finger, MYND domain containing 11 (ENSG00000015171), score: -0.64 ZNF438zinc finger protein 438 (ENSG00000183621), score: 0.62 ZNF644zinc finger protein 644 (ENSG00000122482), score: 0.56 ZNRF4zinc and ring finger 4 (ENSG00000105428), score: 0.64 ZPBPzona pellucida binding protein (ENSG00000042813), score: 0.68 ZPBP2zona pellucida binding protein 2 (ENSG00000186075), score: 0.55

Non-Entrez genes

ENSG00000042813Unknown, score: 0.6 ENSG00000136122Unknown, score: 0.75 ENSG00000170788Unknown, score: 0.67 ENSG00000037637Unknown, score: 0.58

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Id species tissue sex individual
gga_ts_m1_ca1 gga ts m 1
gga_ts_m2_ca1 gga ts m 2
oan_ts_m2_ca1 oan ts m 2
oan_ts_m1_ca1 oan ts m 1
oan_ts_m3_ca1 oan ts m 3

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© 2008-2010 Computational Biology Group, Department of Medical Genetics, University of Lausanne, Switzerland