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Expression data for module #451

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

protein maturation by peptide bond cleavage

The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

cytolysis

The rupture of cell membranes and the loss of cytoplasm.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

amine catabolic process

The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

response to biotic stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to organic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

gene expression

The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

protein processing

Any protein maturation process achieved by the cleavage of peptide bonds.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

cholesterol homeostasis

Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

response to protein stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.

lipid homeostasis

Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.

sterol homeostasis

Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

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cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

peroxisome

A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

peroxisomal part

Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

microbody

Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

microbody part

Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

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cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

microbody

Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

microbody part

Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

intrinsic to organelle membrane

Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

microbody part

Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

peroxisomal part

Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

Help | Hide | Top The GO tree — Molecular Function

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

lyase activity

Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

carbon-sulfur lyase activity

Catalysis of the elimination of H2S or substituted H2S.

vitamin binding

Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

amine binding

Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.

cofactor binding

Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

coenzyme binding

Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

vitamin B6 binding

Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.

all

NA

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04610 2.298e-03 1.381 8
21 Complement and coagulation cascades
00260 3.604e-02 0.8546 5
13 Glycine, serine and threonine metabolism
01100 3.947e-02 23.21 37
353 Metabolic pathways
02010 4.724e-02 0.9204 5
14 ABC transporters

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (ENSG00000165029), score: 0.37 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.46 ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ENSG00000023839), score: 0.36 ABCD3ATP-binding cassette, sub-family D (ALD), member 3 (ENSG00000117528), score: 0.51 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.46 ABI2abl-interactor 2 (ENSG00000138443), score: -0.42 ACBD5acyl-CoA binding domain containing 5 (ENSG00000107897), score: 0.43 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.38 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.37 ADAP2ArfGAP with dual PH domains 2 (ENSG00000184060), score: 0.36 ALAS1aminolevulinate, delta-, synthase 1 (ENSG00000023330), score: 0.43 ALBalbumin (ENSG00000163631), score: 0.34 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.34 AMMECR1LAMME chromosomal region gene 1-like (ENSG00000144233), score: 0.42 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.34 AP3M1adaptor-related protein complex 3, mu 1 subunit (ENSG00000185009), score: 0.34 AQP8aquaporin 8 (ENSG00000103375), score: 0.56 ARCN1archain 1 (ENSG00000095139), score: 0.35 ARHGAP42Rho GTPase activating protein 42 (ENSG00000165895), score: 0.43 ATL2atlastin GTPase 2 (ENSG00000119787), score: 0.43 ATPAF1ATP synthase mitochondrial F1 complex assembly factor 1 (ENSG00000123472), score: -0.4 ATPIF1ATPase inhibitory factor 1 (ENSG00000130770), score: -0.39 AVPR1Aarginine vasopressin receptor 1A (ENSG00000166148), score: 0.35 B4GALT2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (ENSG00000117411), score: -0.55 BBS2Bardet-Biedl syndrome 2 (ENSG00000125124), score: -0.59 BPNT13'(2'), 5'-bisphosphate nucleotidase 1 (ENSG00000162813), score: 0.34 BRAPBRCA1 associated protein (ENSG00000089234), score: 0.33 C12orf72chromosome 12 open reading frame 72 (ENSG00000139160), score: 0.51 C13orf15chromosome 13 open reading frame 15 (ENSG00000102760), score: -0.4 C16orf70chromosome 16 open reading frame 70 (ENSG00000125149), score: 0.42 C19orf12chromosome 19 open reading frame 12 (ENSG00000131943), score: 0.4 C1orf91chromosome 1 open reading frame 91 (ENSG00000160055), score: 0.36 C2CD2C2 calcium-dependent domain containing 2 (ENSG00000157617), score: 0.49 C5complement component 5 (ENSG00000106804), score: 0.38 C5orf33chromosome 5 open reading frame 33 (ENSG00000152620), score: 0.35 C7orf23chromosome 7 open reading frame 23 (ENSG00000135185), score: 0.55 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.34 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.34 C8Gcomplement component 8, gamma polypeptide (ENSG00000176919), score: 0.33 C9orf150chromosome 9 open reading frame 150 (ENSG00000153714), score: 0.37 CA1carbonic anhydrase I (ENSG00000133742), score: 0.44 CASP8caspase 8, apoptosis-related cysteine peptidase (ENSG00000064012), score: 0.37 CCBL2cysteine conjugate-beta lyase 2 (ENSG00000137944), score: 0.52 CCDC92coiled-coil domain containing 92 (ENSG00000119242), score: -0.42 CCRL1chemokine (C-C motif) receptor-like 1 (ENSG00000129048), score: 0.51 CDK8cyclin-dependent kinase 8 (ENSG00000132964), score: 0.47 CDO1cysteine dioxygenase, type I (ENSG00000129596), score: 0.34 CGRRF1cell growth regulator with ring finger domain 1 (ENSG00000100532), score: 0.38 CHUKconserved helix-loop-helix ubiquitous kinase (ENSG00000213341), score: 0.43 CIB3calcium and integrin binding family member 3 (ENSG00000141977), score: 0.52 CLDN14claudin 14 (ENSG00000159261), score: 0.33 CLEC3BC-type lectin domain family 3, member B (ENSG00000163815), score: -0.4 CMTM8CKLF-like MARVEL transmembrane domain containing 8 (ENSG00000170293), score: 0.33 CNR2cannabinoid receptor 2 (macrophage) (ENSG00000188822), score: 0.79 COL10A1collagen, type X, alpha 1 (ENSG00000123500), score: 0.37 COPB2coatomer protein complex, subunit beta 2 (beta prime) (ENSG00000184432), score: 0.36 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.36 CPOXcoproporphyrinogen oxidase (ENSG00000080819), score: 0.41 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.39 CREG1cellular repressor of E1A-stimulated genes 1 (ENSG00000143162), score: 0.34 CROTcarnitine O-octanoyltransferase (ENSG00000005469), score: 0.45 CTHcystathionase (cystathionine gamma-lyase) (ENSG00000116761), score: 0.33 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.46 DCLRE1ADNA cross-link repair 1A (ENSG00000198924), score: 0.42 DCTdopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) (ENSG00000080166), score: 0.41 DEPDC6DEP domain containing 6 (ENSG00000155792), score: 0.34 DERL1Der1-like domain family, member 1 (ENSG00000136986), score: 0.33 DERL2Der1-like domain family, member 2 (ENSG00000072849), score: 0.42 DHCR2424-dehydrocholesterol reductase (ENSG00000116133), score: 0.33 DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila) (ENSG00000160305), score: -0.45 DLEC1deleted in lung and esophageal cancer 1 (ENSG00000008226), score: 0.35 DMGDHdimethylglycine dehydrogenase (ENSG00000132837), score: 0.35 DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22 (ENSG00000178401), score: 0.39 DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 3 (ENSG00000102580), score: 0.44 DNTTdeoxynucleotidyltransferase, terminal (ENSG00000107447), score: 0.62 EDEM1ER degradation enhancer, mannosidase alpha-like 1 (ENSG00000134109), score: 0.37 EGFRepidermal growth factor receptor (ENSG00000146648), score: 0.46 ELK4ELK4, ETS-domain protein (SRF accessory protein 1) (ENSG00000158711), score: 0.36 ERN1endoplasmic reticulum to nucleus signaling 1 (ENSG00000178607), score: 0.44 EVI5ecotropic viral integration site 5 (ENSG00000067208), score: 0.35 F10coagulation factor X (ENSG00000126218), score: 0.37 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.35 FABP2fatty acid binding protein 2, intestinal (ENSG00000145384), score: 1 FAM105Bfamily with sequence similarity 105, member B (ENSG00000154124), score: 0.38 FAM160B1family with sequence similarity 160, member B1 (ENSG00000151553), score: 0.41 FAM175Bfamily with sequence similarity 175, member B (ENSG00000165660), score: 0.33 FAM59Afamily with sequence similarity 59, member A (ENSG00000141441), score: 0.37 FAM82A1family with sequence similarity 82, member A1 (ENSG00000115841), score: 0.33 FAR1fatty acyl CoA reductase 1 (ENSG00000197601), score: -0.41 FDXRferredoxin reductase (ENSG00000161513), score: 0.35 FETUBfetuin B (ENSG00000090512), score: 0.39 FGD6FYVE, RhoGEF and PH domain containing 6 (ENSG00000180263), score: 0.41 GCH1GTP cyclohydrolase 1 (ENSG00000131979), score: 0.35 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.34 GFRA1GDNF family receptor alpha 1 (ENSG00000151892), score: 0.46 GGPS1geranylgeranyl diphosphate synthase 1 (ENSG00000152904), score: -0.43 GJB2gap junction protein, beta 2, 26kDa (ENSG00000165474), score: 0.49 GLO1glyoxalase I (ENSG00000124767), score: 0.33 GM2AGM2 ganglioside activator (ENSG00000196743), score: 0.36 GNAI1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (ENSG00000127955), score: -0.47 GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (ENSG00000159921), score: 0.51 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.44 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.47 GPR180G protein-coupled receptor 180 (ENSG00000152749), score: 0.4 GPR97G protein-coupled receptor 97 (ENSG00000182885), score: 0.35 GPT2glutamic pyruvate transaminase (alanine aminotransferase) 2 (ENSG00000166123), score: 0.41 H1FXH1 histone family, member X (ENSG00000184897), score: -0.53 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (ENSG00000049239), score: 0.44 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.44 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.35 HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (ENSG00000051108), score: 0.4 HMGCR3-hydroxy-3-methylglutaryl-CoA reductase (ENSG00000113161), score: 0.38 HNRNPRheterogeneous nuclear ribonucleoprotein R (ENSG00000125944), score: -0.45 HTRA1HtrA serine peptidase 1 (ENSG00000166033), score: -0.47 ICOSinducible T-cell co-stimulator (ENSG00000163600), score: 0.37 IFFO1intermediate filament family orphan 1 (ENSG00000010295), score: -0.45 IFT57intraflagellar transport 57 homolog (Chlamydomonas) (ENSG00000114446), score: -0.42 IGF1insulin-like growth factor 1 (somatomedin C) (ENSG00000017427), score: 0.43 IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (ENSG00000143466), score: 0.36 IL1RAPinterleukin 1 receptor accessory protein (ENSG00000196083), score: 0.42 ITCHitchy E3 ubiquitin protein ligase homolog (mouse) (ENSG00000078747), score: 0.34 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.35 JAM3junctional adhesion molecule 3 (ENSG00000166086), score: -0.45 KIAA2018KIAA2018 (ENSG00000176542), score: 0.33 KLBklotho beta (ENSG00000134962), score: 0.42 LAMP2lysosomal-associated membrane protein 2 (ENSG00000005893), score: 0.37 LARP4BLa ribonucleoprotein domain family, member 4B (ENSG00000107929), score: 0.38 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.4 LIFRleukemia inhibitory factor receptor alpha (ENSG00000113594), score: 0.6 LIPClipase, hepatic (ENSG00000166035), score: 0.42 LPGAT1lysophosphatidylglycerol acyltransferase 1 (ENSG00000123684), score: 0.37 LPIN1lipin 1 (ENSG00000134324), score: 0.41 LPIN2lipin 2 (ENSG00000101577), score: 0.33 LRIT2leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 (ENSG00000204033), score: 0.57 MAN2A1mannosidase, alpha, class 2A, member 1 (ENSG00000112893), score: 0.39 MAP1Dmethionine aminopeptidase 1D (ENSG00000172878), score: 0.38 MARCH5membrane-associated ring finger (C3HC4) 5 (ENSG00000198060), score: 0.44 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.39 MBIPMAP3K12 binding inhibitory protein 1 (ENSG00000151332), score: -0.45 MCM10minichromosome maintenance complex component 10 (ENSG00000065328), score: 0.62 MCRS1microspherule protein 1 (ENSG00000187778), score: -0.5 ME3malic enzyme 3, NADP(+)-dependent, mitochondrial (ENSG00000151376), score: -0.4 MEAF6MYST/Esa1-associated factor 6 (ENSG00000163875), score: -0.41 MIA3melanoma inhibitory activity family, member 3 (ENSG00000154305), score: 0.51 MIPOL1mirror-image polydactyly 1 (ENSG00000151338), score: 0.4 MOCOSmolybdenum cofactor sulfurase (ENSG00000075643), score: 0.37 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.34 NADKNAD kinase (ENSG00000008130), score: 0.36 NAPEPLDN-acyl phosphatidylethanolamine phospholipase D (ENSG00000161048), score: -0.44 NEDD4neural precursor cell expressed, developmentally down-regulated 4 (ENSG00000069869), score: 0.37 NHLRC2NHL repeat containing 2 (ENSG00000196865), score: 0.33 NIPAL1NIPA-like domain containing 1 (ENSG00000163293), score: 0.39 NPC1Niemann-Pick disease, type C1 (ENSG00000141458), score: 0.36 NR1H4nuclear receptor subfamily 1, group H, member 4 (ENSG00000012504), score: 0.34 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.37 NSDHLNAD(P) dependent steroid dehydrogenase-like (ENSG00000147383), score: 0.34 NSL1NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) (ENSG00000117697), score: -0.4 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.41 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.44 P4HTMprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) (ENSG00000178467), score: -0.44 PAHphenylalanine hydroxylase (ENSG00000171759), score: 0.34 PAK1IP1PAK1 interacting protein 1 (ENSG00000111845), score: 0.36 PANK1pantothenate kinase 1 (ENSG00000152782), score: 0.36 PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2 (ENSG00000198682), score: 0.33 PARD3par-3 partitioning defective 3 homolog (C. elegans) (ENSG00000148498), score: 0.35 PCSK9proprotein convertase subtilisin/kexin type 9 (ENSG00000169174), score: 0.33 PEX11Aperoxisomal biogenesis factor 11 alpha (ENSG00000166821), score: 0.41 PEX16peroxisomal biogenesis factor 16 (ENSG00000121680), score: 0.42 PGAP3post-GPI attachment to proteins 3 (ENSG00000161395), score: -0.43 PIK3IP1phosphoinositide-3-kinase interacting protein 1 (ENSG00000100100), score: -0.48 PLK3polo-like kinase 3 (ENSG00000173846), score: 0.56 PM20D1peptidase M20 domain containing 1 (ENSG00000162877), score: 0.33 POLR3Gpolymerase (RNA) III (DNA directed) polypeptide G (32kD) (ENSG00000113356), score: 0.35 PPP1R15Bprotein phosphatase 1, regulatory (inhibitor) subunit 15B (ENSG00000158615), score: 0.47 PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha (ENSG00000066027), score: 0.4 PRKD3protein kinase D3 (ENSG00000115825), score: 0.53 PRLRprolactin receptor (ENSG00000113494), score: 0.49 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.36 PSEN2presenilin 2 (Alzheimer disease 4) (ENSG00000143801), score: 0.44 PSMA4proteasome (prosome, macropain) subunit, alpha type, 4 (ENSG00000041357), score: 0.36 PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (ENSG00000197170), score: 0.35 PSTPIP2proline-serine-threonine phosphatase interacting protein 2 (ENSG00000152229), score: 0.34 PYGLphosphorylase, glycogen, liver (ENSG00000100504), score: 0.35 QSOX1quiescin Q6 sulfhydryl oxidase 1 (ENSG00000116260), score: 0.44 RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (ENSG00000173166), score: 0.34 RDXradixin (ENSG00000137710), score: 0.35 RGNregucalcin (senescence marker protein-30) (ENSG00000130988), score: 0.33 RNF34ring finger protein 34 (ENSG00000170633), score: -0.44 RXRAretinoid X receptor, alpha (ENSG00000186350), score: 0.36 SARDHsarcosine dehydrogenase (ENSG00000123453), score: 0.4 SCCPDHsaccharopine dehydrogenase (putative) (ENSG00000143653), score: -0.59 SCLYselenocysteine lyase (ENSG00000132330), score: 0.33 SDR42E1short chain dehydrogenase/reductase family 42E, member 1 (ENSG00000184860), score: 0.53 SEC16BSEC16 homolog B (S. cerevisiae) (ENSG00000120341), score: 0.33 SEC63SEC63 homolog (S. cerevisiae) (ENSG00000025796), score: 0.36 SEPSECSSep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (ENSG00000109618), score: 0.39 SEPT6septin 6 (ENSG00000125354), score: -0.43 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.35 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.34 SESTD1SEC14 and spectrin domains 1 (ENSG00000187231), score: -0.4 SGCBsarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (ENSG00000163069), score: -0.44 SIRT3sirtuin 3 (ENSG00000142082), score: 0.34 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (ENSG00000125255), score: 0.4 SLC16A10solute carrier family 16, member 10 (aromatic amino acid transporter) (ENSG00000112394), score: 0.43 SLC17A8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 (ENSG00000179520), score: 0.74 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (ENSG00000117479), score: 0.43 SLC25A16solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 (ENSG00000122912), score: 0.33 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.4 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.33 SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (ENSG00000116704), score: 0.41 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.43 SLC39A6solute carrier family 39 (zinc transporter), member 6 (ENSG00000141424), score: -0.39 SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (ENSG00000003989), score: 0.36 SLC7A6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (ENSG00000103064), score: -0.49 SLCO2B1solute carrier organic anion transporter family, member 2B1 (ENSG00000137491), score: 0.34 SLIT3slit homolog 3 (Drosophila) (ENSG00000184347), score: -0.42 SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (ENSG00000102038), score: -0.44 SMEK1SMEK homolog 1, suppressor of mek1 (Dictyostelium) (ENSG00000100796), score: 0.33 SMYD4SET and MYND domain containing 4 (ENSG00000186532), score: -0.41 SNNstannin (ENSG00000184602), score: -0.4 SNTG2syntrophin, gamma 2 (ENSG00000172554), score: 0.47 SNX17sorting nexin 17 (ENSG00000115234), score: -0.41 SQLEsqualene epoxidase (ENSG00000104549), score: 0.34 SSPNsarcospan (Kras oncogene-associated gene) (ENSG00000123096), score: 0.4 ST3GAL5ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ENSG00000115525), score: 0.42 STARD5StAR-related lipid transfer (START) domain containing 5 (ENSG00000172345), score: 0.38 SUN1Sad1 and UNC84 domain containing 1 (ENSG00000164828), score: -0.43 TAPT1transmembrane anterior posterior transformation 1 (ENSG00000169762), score: 0.36 TARSthreonyl-tRNA synthetase (ENSG00000113407), score: 0.39 TATtyrosine aminotransferase (ENSG00000198650), score: 0.42 TBCELtubulin folding cofactor E-like (ENSG00000154114), score: 0.33 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.42 TERTtelomerase reverse transcriptase (ENSG00000164362), score: 0.37 TGDSTDP-glucose 4,6-dehydratase (ENSG00000088451), score: 0.4 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.35 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.36 TMEM195transmembrane protein 195 (ENSG00000187546), score: 0.42 TMEM20transmembrane protein 20 (ENSG00000176273), score: 0.39 TMEM231transmembrane protein 231 (ENSG00000205084), score: -0.39 TMEM56transmembrane protein 56 (ENSG00000152078), score: 0.36 TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) (ENSG00000154174), score: 0.38 TOR1Atorsin family 1, member A (torsin A) (ENSG00000136827), score: 0.4 TRIB2tribbles homolog 2 (Drosophila) (ENSG00000071575), score: -0.4 TSPAN3tetraspanin 3 (ENSG00000140391), score: -0.74 TSR1TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) (ENSG00000167721), score: 0.35 TTC39Ctetratricopeptide repeat domain 39C (ENSG00000168234), score: 0.5 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.41 TULP3tubby like protein 3 (ENSG00000078246), score: -0.44 TXNDC15thioredoxin domain containing 15 (ENSG00000113621), score: 0.37 TYW3tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) (ENSG00000162623), score: -0.45 UBR2ubiquitin protein ligase E3 component n-recognin 2 (ENSG00000024048), score: 0.4 UVRAGUV radiation resistance associated gene (ENSG00000198382), score: 0.35 WDR36WD repeat domain 36 (ENSG00000134987), score: 0.35 WDR89WD repeat domain 89 (ENSG00000140006), score: 0.37 WRBtryptophan rich basic protein (ENSG00000182093), score: -0.4 XKR9XK, Kell blood group complex subunit-related family, member 9 (ENSG00000221947), score: 0.49 ZAP70zeta-chain (TCR) associated protein kinase 70kDa (ENSG00000115085), score: 0.44 ZC3H7Azinc finger CCCH-type containing 7A (ENSG00000122299), score: 0.51 ZDHHC6zinc finger, DHHC-type containing 6 (ENSG00000023041), score: 0.36 ZNF462zinc finger protein 462 (ENSG00000148143), score: -0.39 ZNF518Bzinc finger protein 518B (ENSG00000178163), score: -0.4 ZNF750zinc finger protein 750 (ENSG00000141579), score: 0.77 ZNF827zinc finger protein 827 (ENSG00000151612), score: -0.45

Non-Entrez genes

Unknown, score:

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Id species tissue sex individual
mmu_lv_m1_ca1 mmu lv m 1
mmu_lv_f_ca1 mmu lv f _
mmu_lv_m2_ca1 mmu lv m 2

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© 2008-2010 Computational Biology Group, Department of Medical Genetics, University of Lausanne, Switzerland