Under-expression is coded with green,
over-expression with red color.
sulfur metabolic process
The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
adaptive immune response
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
immune effector process
Any process of the immune system that occurs as part of an immune response.
activation of immune response
Any process that initiates an immune response.
immune system process
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
leukocyte mediated immunity
Any process involved in the carrying out of an immune response by a leukocyte.
lymphocyte mediated immunity
Any process involved in the carrying out of an immune response by a lymphocyte.
humoral immune response mediated by circulating immunoglobulin
An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
acute inflammatory response
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
activation of plasma proteins involved in acute inflammatory response
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
regulation of immune system process
Any process that modulates the frequency, rate, or extent of an immune system process.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
response to unfolded protein
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
defense response
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
alcohol metabolic process
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
pyruvate metabolic process
The chemical reactions and pathways involving pyruvate, 2-oxopropanoate.
oxidation reduction
The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons.
protein maturation by peptide bond cleavage
The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
cellular amino acid derivative metabolic process
The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
lipid metabolic process
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
cellular aromatic compound metabolic process
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
coenzyme metabolic process
The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.
nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
response to stress
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
immune response
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
complement activation, alternative pathway
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
complement activation, classical pathway
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
humoral immune response
An immune response mediated through a body fluid.
organelle organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
peroxisome organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
steroid metabolic process
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
bile acid metabolic process
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
serine family amino acid metabolic process
The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
aromatic amino acid family metabolic process
The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
aromatic amino acid family catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
amine catabolic process
The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
response to biotic stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
response to organic substance
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
gene expression
The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
lipid catabolic process
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
cellular component organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
immunoglobulin mediated immune response
An immune response mediated by immunoglobulins, whether cell-bound or in solution.
protein processing
Any protein maturation process achieved by the cleavage of peptide bonds.
aromatic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
B cell mediated immunity
Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
carboxylic acid metabolic process
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
monocarboxylic acid metabolic process
The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
wound healing
The series of events that restore integrity to a damaged tissue, following an injury.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
response to chemical stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
homeostatic process
Any biological process involved in the maintenance of an internal steady-state.
cholesterol homeostasis
Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.
macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
small molecule metabolic process
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
innate immune response
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
carboxylic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
heterocycle metabolic process
The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
coagulation
The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
cofactor metabolic process
The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
protein maturation
Any process leading to the attainment of the full functional capacity of a protein.
response to protein stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.
lipid homeostasis
Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.
sterol homeostasis
Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
all
NA
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
organelle organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
regulation of immune system process
Any process that modulates the frequency, rate, or extent of an immune system process.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
immune response
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
cellular amino acid and derivative metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
immune effector process
Any process of the immune system that occurs as part of an immune response.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
response to unfolded protein
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
cellular amine metabolic process
The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
protein maturation
Any process leading to the attainment of the full functional capacity of a protein.
organic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
aromatic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
lipid catabolic process
The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
activation of immune response
Any process that initiates an immune response.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
complement activation, alternative pathway
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
innate immune response
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
aromatic amino acid family metabolic process
The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
aromatic amino acid family catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
B cell mediated immunity
Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
complement activation, classical pathway
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
response to unfolded protein
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
aromatic amino acid family catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
cellular amino acid catabolic process
The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
cellular amino acid metabolic process
The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.
carboxylic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
activation of plasma proteins involved in acute inflammatory response
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
bile acid metabolic process
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
humoral immune response mediated by circulating immunoglobulin
An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
cell fraction
A generic term for parts of cells prepared by disruptive biochemical techniques.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
peroxisome
A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
membrane attack complex
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
stored secretory granule
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
endomembrane system
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
pore complex
Any small opening in a membrane that allows the passage of gases and/or liquids.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
organelle membrane
The lipid bilayer surrounding an organelle.
platelet alpha granule
A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).
platelet alpha granule lumen
The volume enclosed by the membrane of the platelet alpha granule.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
membrane-enclosed lumen
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
vesicle
Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
vesicle lumen
The volume enclosed by the membrane or protein that forms a vesicle.
membrane-bounded vesicle
Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
nuclear membrane-endoplasmic reticulum network
The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.
microbody
Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
cytoplasmic membrane-bounded vesicle lumen
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
all
NA
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
organelle membrane
The lipid bilayer surrounding an organelle.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
organelle membrane
The lipid bilayer surrounding an organelle.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
nuclear membrane-endoplasmic reticulum network
The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
nuclear membrane-endoplasmic reticulum network
The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
vesicle lumen
The volume enclosed by the membrane or protein that forms a vesicle.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
cytoplasmic membrane-bounded vesicle lumen
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
endoplasmic reticulum membrane
The lipid bilayer surrounding the endoplasmic reticulum.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
microbody
Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
subsynaptic reticulum
An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.
membrane attack complex
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
cytoplasmic membrane-bounded vesicle lumen
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
endoplasmic reticulum part
Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.
pore complex
Any small opening in a membrane that allows the passage of gases and/or liquids.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
membrane attack complex
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
platelet alpha granule lumen
The volume enclosed by the membrane of the platelet alpha granule.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
folic acid binding
Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
oxidoreductase activity
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
amino acid binding
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
lyase activity
Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
carbon-sulfur lyase activity
Catalysis of the elimination of H2S or substituted H2S.
vitamin binding
Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.
pyridoxal phosphate binding
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
carboxylic acid binding
Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
amine binding
Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.
cofactor binding
Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
vitamin B6 binding
Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.
all
NA
amino acid binding
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
pyridoxal phosphate binding
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
folic acid binding
Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 04610 | 1.368e-05 | 1.596 | 11 | 21 | Complement and coagulation cascades |
| 04146 | 3.006e-03 | 2.28 | 10 | 30 | Peroxisome |
| 00260 | 1.108e-02 | 0.9879 | 6 | 13 | Glycine, serine and threonine metabolism |
| 00120 | 2.047e-02 | 0.228 | 3 | 3 | Primary bile acid biosynthesis |
| 01100 | 4.939e-02 | 26.83 | 41 | 353 | Metabolic pathways |
A1CFAPOBEC1 complementation factor (ENSG00000148584), score: 0.48 ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (ENSG00000165029), score: 0.63 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.61 ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ENSG00000023839), score: 0.49 ABCD3ATP-binding cassette, sub-family D (ALD), member 3 (ENSG00000117528), score: 0.74 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.64 ABI2abl-interactor 2 (ENSG00000138443), score: -0.56 ACBD5acyl-CoA binding domain containing 5 (ENSG00000107897), score: 0.65 ACER2alkaline ceramidase 2 (ENSG00000177076), score: 0.48 ACO1aconitase 1, soluble (ENSG00000122729), score: 0.48 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.6 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.58 ADAP2ArfGAP with dual PH domains 2 (ENSG00000184060), score: 0.51 AGXTalanine-glyoxylate aminotransferase (ENSG00000172482), score: 0.52 AK2adenylate kinase 2 (ENSG00000004455), score: 0.51 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.55 ALAS1aminolevulinate, delta-, synthase 1 (ENSG00000023330), score: 0.56 ALBalbumin (ENSG00000163631), score: 0.56 ALDH8A1aldehyde dehydrogenase 8 family, member A1 (ENSG00000118514), score: 0.46 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.5 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.54 AMMECR1LAMME chromosomal region gene 1-like (ENSG00000144233), score: 0.51 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.47 AQP8aquaporin 8 (ENSG00000103375), score: 0.48 ARCN1archain 1 (ENSG00000095139), score: 0.52 ARHGEF38Rho guanine nucleotide exchange factor (GEF) 38 (ENSG00000138784), score: 0.46 ASPGasparaginase homolog (S. cerevisiae) (ENSG00000166183), score: 0.5 ATL2atlastin GTPase 2 (ENSG00000119787), score: 0.56 ATP13A3ATPase type 13A3 (ENSG00000133657), score: 0.48 ATP2B4ATPase, Ca++ transporting, plasma membrane 4 (ENSG00000058668), score: -0.57 ATP8B1ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ENSG00000081923), score: 0.47 AVPR1Aarginine vasopressin receptor 1A (ENSG00000166148), score: 0.57 BBS2Bardet-Biedl syndrome 2 (ENSG00000125124), score: -0.61 BCMO1beta-carotene 15,15'-monooxygenase 1 (ENSG00000135697), score: 0.54 BMP2bone morphogenetic protein 2 (ENSG00000125845), score: 0.45 C13orf15chromosome 13 open reading frame 15 (ENSG00000102760), score: -0.57 C16orf70chromosome 16 open reading frame 70 (ENSG00000125149), score: 0.48 C5complement component 5 (ENSG00000106804), score: 0.61 C5orf33chromosome 5 open reading frame 33 (ENSG00000152620), score: 0.45 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.59 C8Gcomplement component 8, gamma polypeptide (ENSG00000176919), score: 0.53 C9orf150chromosome 9 open reading frame 150 (ENSG00000153714), score: 0.56 CA1carbonic anhydrase I (ENSG00000133742), score: 0.68 CAPRIN2caprin family member 2 (ENSG00000110888), score: -0.6 CCBL2cysteine conjugate-beta lyase 2 (ENSG00000137944), score: 0.62 CCDC92coiled-coil domain containing 92 (ENSG00000119242), score: -0.64 CCRL1chemokine (C-C motif) receptor-like 1 (ENSG00000129048), score: 0.62 CDK8cyclin-dependent kinase 8 (ENSG00000132964), score: 0.45 CDO1cysteine dioxygenase, type I (ENSG00000129596), score: 0.53 CHUKconserved helix-loop-helix ubiquitous kinase (ENSG00000213341), score: 0.52 CIB3calcium and integrin binding family member 3 (ENSG00000141977), score: 0.47 CMTM8CKLF-like MARVEL transmembrane domain containing 8 (ENSG00000170293), score: 0.45 CNR2cannabinoid receptor 2 (macrophage) (ENSG00000188822), score: 1 COLEC10collectin sub-family member 10 (C-type lectin) (ENSG00000184374), score: 0.46 COPB2coatomer protein complex, subunit beta 2 (beta prime) (ENSG00000184432), score: 0.5 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.56 CPOXcoproporphyrinogen oxidase (ENSG00000080819), score: 0.46 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.63 CREG1cellular repressor of E1A-stimulated genes 1 (ENSG00000143162), score: 0.49 CROTcarnitine O-octanoyltransferase (ENSG00000005469), score: 0.46 CRYGNcrystallin, gamma N (ENSG00000127377), score: 0.53 CTHcystathionase (cystathionine gamma-lyase) (ENSG00000116761), score: 0.58 CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1 (ENSG00000146233), score: 0.58 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.65 DARSaspartyl-tRNA synthetase (ENSG00000115866), score: 0.48 DERL1Der1-like domain family, member 1 (ENSG00000136986), score: 0.53 DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila) (ENSG00000160305), score: -0.53 DMGDHdimethylglycine dehydrogenase (ENSG00000132837), score: 0.49 DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22 (ENSG00000178401), score: 0.56 DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 3 (ENSG00000102580), score: 0.51 DNTTdeoxynucleotidyltransferase, terminal (ENSG00000107447), score: 0.56 EDEM1ER degradation enhancer, mannosidase alpha-like 1 (ENSG00000134109), score: 0.49 EEA1early endosome antigen 1 (ENSG00000102189), score: 0.48 EGFRepidermal growth factor receptor (ENSG00000146648), score: 0.64 EPHA1EPH receptor A1 (ENSG00000146904), score: 0.46 ERN1endoplasmic reticulum to nucleus signaling 1 (ENSG00000178607), score: 0.62 EVI5ecotropic viral integration site 5 (ENSG00000067208), score: 0.5 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.54 F9coagulation factor IX (ENSG00000101981), score: 0.55 FABP2fatty acid binding protein 2, intestinal (ENSG00000145384), score: 0.95 FAM105Bfamily with sequence similarity 105, member B (ENSG00000154124), score: 0.54 FAM160B1family with sequence similarity 160, member B1 (ENSG00000151553), score: 0.58 FAM176Afamily with sequence similarity 176, member A (ENSG00000115363), score: 0.46 FAM69Bfamily with sequence similarity 69, member B (ENSG00000165716), score: -0.56 FAM82A2family with sequence similarity 82, member A2 (ENSG00000137824), score: 0.47 FAR1fatty acyl CoA reductase 1 (ENSG00000197601), score: -0.57 FBXO3F-box protein 3 (ENSG00000110429), score: 0.52 FETUBfetuin B (ENSG00000090512), score: 0.71 FGBfibrinogen beta chain (ENSG00000171564), score: 0.51 FGD6FYVE, RhoGEF and PH domain containing 6 (ENSG00000180263), score: 0.47 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.52 FN1fibronectin 1 (ENSG00000115414), score: 0.56 GBE1glucan (1,4-alpha-), branching enzyme 1 (ENSG00000114480), score: 0.49 GCH1GTP cyclohydrolase 1 (ENSG00000131979), score: 0.53 GCLMglutamate-cysteine ligase, modifier subunit (ENSG00000023909), score: 0.5 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.52 GJB1gap junction protein, beta 1, 32kDa (ENSG00000169562), score: 0.48 GJB2gap junction protein, beta 2, 26kDa (ENSG00000165474), score: 0.53 GLO1glyoxalase I (ENSG00000124767), score: 0.46 GLT25D1glycosyltransferase 25 domain containing 1 (ENSG00000130309), score: 0.48 GMPRguanosine monophosphate reductase (ENSG00000137198), score: -0.63 GNAI1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (ENSG00000127955), score: -0.54 GNB5guanine nucleotide binding protein (G protein), beta 5 (ENSG00000069966), score: -0.53 GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (ENSG00000159921), score: 0.66 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.63 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.61 GPR146G protein-coupled receptor 146 (ENSG00000164849), score: 0.5 GXYLT1glucoside xylosyltransferase 1 (ENSG00000151233), score: 0.51 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (ENSG00000049239), score: 0.56 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.74 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.57 HEBP1heme binding protein 1 (ENSG00000013583), score: 0.5 HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (ENSG00000051108), score: 0.49 HGDhomogentisate 1,2-dioxygenase (ENSG00000113924), score: 0.46 HGFhepatocyte growth factor (hepapoietin A; scatter factor) (ENSG00000019991), score: 0.51 HNRNPRheterogeneous nuclear ribonucleoprotein R (ENSG00000125944), score: -0.57 HPXhemopexin (ENSG00000110169), score: 0.53 HRGhistidine-rich glycoprotein (ENSG00000113905), score: 0.51 HTRA1HtrA serine peptidase 1 (ENSG00000166033), score: -0.72 IGF1insulin-like growth factor 1 (somatomedin C) (ENSG00000017427), score: 0.72 IGFBP1insulin-like growth factor binding protein 1 (ENSG00000146678), score: 0.45 IL1RAPinterleukin 1 receptor accessory protein (ENSG00000196083), score: 0.49 IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor) (ENSG00000134352), score: 0.57 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.56 JAG2jagged 2 (ENSG00000184916), score: -0.55 JAM3junctional adhesion molecule 3 (ENSG00000166086), score: -0.58 KIAA1370KIAA1370 (ENSG00000047346), score: 0.47 KIFAP3kinesin-associated protein 3 (ENSG00000075945), score: -0.62 KLBklotho beta (ENSG00000134962), score: 0.65 KLF15Kruppel-like factor 15 (ENSG00000163884), score: 0.46 KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (ENSG00000117009), score: 0.47 LARP4BLa ribonucleoprotein domain family, member 4B (ENSG00000107929), score: 0.49 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.7 LIFRleukemia inhibitory factor receptor alpha (ENSG00000113594), score: 0.67 LIPClipase, hepatic (ENSG00000166035), score: 0.52 LOC100292202similar to solute carrier family 25, member 25 (ENSG00000148339), score: 0.53 LPGAT1lysophosphatidylglycerol acyltransferase 1 (ENSG00000123684), score: 0.46 LPIN1lipin 1 (ENSG00000134324), score: 0.57 LPIN2lipin 2 (ENSG00000101577), score: 0.58 LRATlecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (ENSG00000121207), score: 0.57 LRIT2leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 (ENSG00000204033), score: 0.52 LYSMD3LysM, putative peptidoglycan-binding, domain containing 3 (ENSG00000176018), score: 0.52 MAN2A1mannosidase, alpha, class 2A, member 1 (ENSG00000112893), score: 0.53 MASP2mannan-binding lectin serine peptidase 2 (ENSG00000009724), score: 0.47 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.6 MCM10minichromosome maintenance complex component 10 (ENSG00000065328), score: 0.66 ME3malic enzyme 3, NADP(+)-dependent, mitochondrial (ENSG00000151376), score: -0.55 MGAT4Amannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A (ENSG00000071073), score: -0.57 MIA3melanoma inhibitory activity family, member 3 (ENSG00000154305), score: 0.62 MINPP1multiple inositol-polyphosphate phosphatase 1 (ENSG00000107789), score: 0.5 MOSPD2motile sperm domain containing 2 (ENSG00000130150), score: 0.45 MPZL2myelin protein zero-like 2 (ENSG00000149573), score: 0.48 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.56 MYH10myosin, heavy chain 10, non-muscle (ENSG00000133026), score: -0.57 MYO1Bmyosin IB (ENSG00000128641), score: 0.48 NADKNAD kinase (ENSG00000008130), score: 0.47 NAPEPLDN-acyl phosphatidylethanolamine phospholipase D (ENSG00000161048), score: -0.62 NECAB3N-terminal EF-hand calcium binding protein 3 (ENSG00000125967), score: -0.6 NPC1Niemann-Pick disease, type C1 (ENSG00000141458), score: 0.52 NR1H4nuclear receptor subfamily 1, group H, member 4 (ENSG00000012504), score: 0.54 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.61 NRBF2nuclear receptor binding factor 2 (ENSG00000148572), score: 0.47 NUDT12nudix (nucleoside diphosphate linked moiety X)-type motif 12 (ENSG00000112874), score: 0.5 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.59 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.71 P4HTMprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) (ENSG00000178467), score: -0.68 PAFAH2platelet-activating factor acetylhydrolase 2, 40kDa (ENSG00000158006), score: 0.52 PAHphenylalanine hydroxylase (ENSG00000171759), score: 0.51 PANK1pantothenate kinase 1 (ENSG00000152782), score: 0.55 PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2 (ENSG00000198682), score: 0.47 PCK1phosphoenolpyruvate carboxykinase 1 (soluble) (ENSG00000124253), score: 0.47 PDCD4programmed cell death 4 (neoplastic transformation inhibitor) (ENSG00000150593), score: 0.53 PDE3Bphosphodiesterase 3B, cGMP-inhibited (ENSG00000152270), score: 0.45 PDP1pyruvate dehyrogenase phosphatase catalytic subunit 1 (ENSG00000164951), score: -0.59 PDP2pyruvate dehyrogenase phosphatase catalytic subunit 2 (ENSG00000172840), score: 0.58 PEMTphosphatidylethanolamine N-methyltransferase (ENSG00000133027), score: 0.5 PEX11Aperoxisomal biogenesis factor 11 alpha (ENSG00000166821), score: 0.55 PEX16peroxisomal biogenesis factor 16 (ENSG00000121680), score: 0.59 PEX7peroxisomal biogenesis factor 7 (ENSG00000112357), score: 0.56 PLA2G12Bphospholipase A2, group XIIB (ENSG00000138308), score: 0.52 PLAAphospholipase A2-activating protein (ENSG00000137055), score: 0.54 PLATplasminogen activator, tissue (ENSG00000104368), score: -0.55 PLK3polo-like kinase 3 (ENSG00000173846), score: 0.57 PM20D1peptidase M20 domain containing 1 (ENSG00000162877), score: 0.55 PPP1R15Bprotein phosphatase 1, regulatory (inhibitor) subunit 15B (ENSG00000158615), score: 0.65 PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha (ENSG00000066027), score: 0.59 PRKD3protein kinase D3 (ENSG00000115825), score: 0.59 PRLRprolactin receptor (ENSG00000113494), score: 0.63 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.53 PSEN2presenilin 2 (Alzheimer disease 4) (ENSG00000143801), score: 0.65 PYGLphosphorylase, glycogen, liver (ENSG00000100504), score: 0.56 RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (ENSG00000173166), score: 0.47 RASSF6Ras association (RalGDS/AF-6) domain family member 6 (ENSG00000169435), score: 0.5 RBP4retinol binding protein 4, plasma (ENSG00000138207), score: 0.46 RCN2reticulocalbin 2, EF-hand calcium binding domain (ENSG00000117906), score: -0.59 RGNregucalcin (senescence marker protein-30) (ENSG00000130988), score: 0.5 RNF144Bring finger protein 144B (ENSG00000137393), score: 0.49 SARDHsarcosine dehydrogenase (ENSG00000123453), score: 0.55 SCARB1scavenger receptor class B, member 1 (ENSG00000073060), score: 0.52 SCLYselenocysteine lyase (ENSG00000132330), score: 0.46 SDR42E1short chain dehydrogenase/reductase family 42E, member 1 (ENSG00000184860), score: 0.55 SEBOXSEBOX homeobox (ENSG00000109072), score: 0.47 SEC16BSEC16 homolog B (S. cerevisiae) (ENSG00000120341), score: 0.52 SEC24DSEC24 family, member D (S. cerevisiae) (ENSG00000150961), score: 0.48 SEC63SEC63 homolog (S. cerevisiae) (ENSG00000025796), score: 0.47 SEPSECSSep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (ENSG00000109618), score: 0.54 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.55 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.57 SETBP1SET binding protein 1 (ENSG00000152217), score: -0.55 SFXN3sideroflexin 3 (ENSG00000107819), score: -0.56 SGCBsarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (ENSG00000163069), score: -0.55 SGPL1sphingosine-1-phosphate lyase 1 (ENSG00000166224), score: 0.45 SLC16A10solute carrier family 16, member 10 (aromatic amino acid transporter) (ENSG00000112394), score: 0.72 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.48 SLC17A8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 (ENSG00000179520), score: 0.89 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (ENSG00000117479), score: 0.6 SLC25A16solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 (ENSG00000122912), score: 0.47 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.65 SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2 (ENSG00000163581), score: 0.52 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.57 SLC30A7solute carrier family 30 (zinc transporter), member 7 (ENSG00000162695), score: 0.46 SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (ENSG00000116704), score: 0.62 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.68 SLC46A1solute carrier family 46 (folate transporter), member 1 (ENSG00000076351), score: 0.51 SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (ENSG00000003989), score: 0.66 SLC7A6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (ENSG00000103064), score: -0.72 SLIT3slit homolog 3 (Drosophila) (ENSG00000184347), score: -0.58 SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (ENSG00000102038), score: -0.67 SMYD4SET and MYND domain containing 4 (ENSG00000186532), score: -0.55 SPIRE1spire homolog 1 (Drosophila) (ENSG00000134278), score: -0.57 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.57 SRD5A2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (ENSG00000049319), score: 0.56 STAB2stabilin 2 (ENSG00000136011), score: 0.51 STARD5StAR-related lipid transfer (START) domain containing 5 (ENSG00000172345), score: 0.65 TATtyrosine aminotransferase (ENSG00000198650), score: 0.66 TBC1D8BTBC1 domain family, member 8B (with GRAM domain) (ENSG00000133138), score: 0.53 TBCELtubulin folding cofactor E-like (ENSG00000154114), score: 0.5 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.68 TEX2testis expressed 2 (ENSG00000136478), score: 0.47 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.6 TMEM20transmembrane protein 20 (ENSG00000176273), score: 0.52 TMEM231transmembrane protein 231 (ENSG00000205084), score: -0.59 TMEM56transmembrane protein 56 (ENSG00000152078), score: 0.51 TOB1transducer of ERBB2, 1 (ENSG00000141232), score: 0.47 TOR1Atorsin family 1, member A (torsin A) (ENSG00000136827), score: 0.58 TOR1Btorsin family 1, member B (torsin B) (ENSG00000136816), score: 0.46 TP53BP1tumor protein p53 binding protein 1 (ENSG00000067369), score: -0.55 TRIB2tribbles homolog 2 (Drosophila) (ENSG00000071575), score: -0.59 TSPAN3tetraspanin 3 (ENSG00000140391), score: -0.78 TSR1TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) (ENSG00000167721), score: 0.48 TTC36tetratricopeptide repeat domain 36 (ENSG00000172425), score: 0.52 TTC39Ctetratricopeptide repeat domain 39C (ENSG00000168234), score: 0.61 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.6 TUBGCP5tubulin, gamma complex associated protein 5 (ENSG00000153575), score: -0.59 TULP3tubby like protein 3 (ENSG00000078246), score: -0.6 TXNRD1thioredoxin reductase 1 (ENSG00000198431), score: 0.55 TYW3tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) (ENSG00000162623), score: -0.54 UBR2ubiquitin protein ligase E3 component n-recognin 2 (ENSG00000024048), score: 0.55 VPS54vacuolar protein sorting 54 homolog (S. cerevisiae) (ENSG00000143952), score: 0.51 VSIG4V-set and immunoglobulin domain containing 4 (ENSG00000155659), score: 0.45 XCR1chemokine (C motif) receptor 1 (ENSG00000173578), score: 0.58 XKR9XK, Kell blood group complex subunit-related family, member 9 (ENSG00000221947), score: 0.76 ZAP70zeta-chain (TCR) associated protein kinase 70kDa (ENSG00000115085), score: 0.46 ZNF750zinc finger protein 750 (ENSG00000141579), score: 0.69
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| mdo_lv_f_ca1 | mdo | lv | f | _ |
| mdo_lv_m_ca1 | mdo | lv | m | _ |
| mmu_lv_m1_ca1 | mmu | lv | m | 1 |
| mmu_lv_f_ca1 | mmu | lv | f | _ |
| mmu_lv_m2_ca1 | mmu | lv | m | 2 |
