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Expression data for module #474

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

regulation of the force of heart contraction

Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.

heart morphogenesis

The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

muscle system process

A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.

circulatory system process

A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.

heart process

A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

muscle contraction

A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

acetyl-CoA metabolic process

The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.

generation of precursor metabolites and energy

The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.

tricarboxylic acid cycle

A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

malate metabolic process

The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.

oxidation reduction

The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons.

respiratory electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

oxidative phosphorylation

The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

mitochondrial electron transport, NADH to ubiquinone

The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.

electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

coenzyme metabolic process

The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

phosphorus metabolic process

The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).

phosphate metabolic process

The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.

blood circulation

The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.

regulation of heart contraction

Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

aerobic respiration

The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.

coenzyme catabolic process

The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

striated muscle tissue development

The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.

energy derivation by oxidation of organic compounds

The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

actin filament-based process

Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

mitochondrial ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

dicarboxylic acid metabolic process

The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

cellular respiration

The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).

acetyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.

intracellular transport

The directed movement of substances within a cell.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

cofactor catabolic process

The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein.

cofactor biosynthetic process

The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

nucleobase, nucleoside and nucleotide metabolic process

The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.

heart contraction

The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.

muscle tissue development

The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.

muscle structure development

The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

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cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

intracellular transport

The directed movement of substances within a cell.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cofactor catabolic process

The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein.

cofactor biosynthetic process

The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein.

nucleobase, nucleoside and nucleotide metabolic process

The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.

ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

coenzyme catabolic process

The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

heart contraction

The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.

regulation of the force of heart contraction

Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

heart morphogenesis

The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

muscle tissue development

The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

respiratory electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

oxidative phosphorylation

The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

acetyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.

regulation of heart contraction

Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

mitochondrial electron transport, NADH to ubiquinone

The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.

tricarboxylic acid cycle

A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

mitochondrial envelope

The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.

mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

mitochondrial matrix

The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

organelle inner membrane

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.

myofibril

The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

NADH dehydrogenase complex

An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.

organelle membrane

The lipid bilayer surrounding an organelle.

A band

The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.

I band

A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

organelle envelope

A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

envelope

A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.

mitochondrial lumen

The volume enclosed by the mitochondrial inner membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

sarcolemma

The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

mitochondrial membrane part

Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

tricarboxylic acid cycle enzyme complex

Any of the heteromeric enzymes that act in the TCA cycle.

respiratory chain complex I

Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

respiratory chain

The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

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NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

organelle envelope

A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

organelle envelope

A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.

organelle inner membrane

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.

NADH dehydrogenase complex

An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

NADH dehydrogenase complex

An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.

organelle inner membrane

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.

mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

mitochondrial membrane part

Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

mitochondrial envelope

The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

mitochondrial lumen

The volume enclosed by the mitochondrial inner membrane.

mitochondrial membrane part

Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

A band

The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.

I band

A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

tricarboxylic acid cycle enzyme complex

Any of the heteromeric enzymes that act in the TCA cycle.

mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

respiratory chain complex I

Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.

mitochondrial matrix

The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.

mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

Help | Hide | Top The GO tree — Molecular Function

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protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

NADH dehydrogenase activity

Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

cytoskeletal protein binding

Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

NADH dehydrogenase (ubiquinone) activity

Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.

oxidoreductase activity, acting on NADH or NADPH

Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.

NADH dehydrogenase (quinone) activity

Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.

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NADH dehydrogenase (quinone) activity

Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
00020 4.779e-05 0.8275 8
14 Citrate cycle (TCA cycle)
04260 8.590e-05 1.478 10
25 Cardiac muscle contraction
00190 4.498e-04 1.773 10
30 Oxidative phosphorylation
05410 1.287e-03 2.01 10
34 Hypertrophic cardiomyopathy (HCM)
01100 1.304e-03 20.86 39
353 Metabolic pathways
05010 2.263e-03 2.601 11
44 Alzheimer's disease
05414 6.292e-03 2.01 9
34 Dilated cardiomyopathy
05012 6.555e-03 1.596 8
27 Parkinson's disease
00280 1.456e-02 1.005 6
17 Valine, leucine and isoleucine degradation
05016 1.935e-02 2.896 10
49 Huntington's disease
00620 4.352e-02 0.8866 5
15 Pyruvate metabolism

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABHD12abhydrolase domain containing 12 (ENSG00000100997), score: -0.62 ABHD2abhydrolase domain containing 2 (ENSG00000140526), score: -0.62 ABHD6abhydrolase domain containing 6 (ENSG00000163686), score: -0.61 ABRAactin-binding Rho activating protein (ENSG00000174429), score: 0.64 ACAD8acyl-CoA dehydrogenase family, member 8 (ENSG00000151498), score: 0.71 ACANaggrecan (ENSG00000157766), score: 0.82 ACOT11acyl-CoA thioesterase 11 (ENSG00000162390), score: 0.51 ACTL6Aactin-like 6A (ENSG00000136518), score: 0.51 ACTN2actinin, alpha 2 (ENSG00000077522), score: 0.54 ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ENSG00000154736), score: 0.54 ADAMTSL5ADAMTS-like 5 (ENSG00000185761), score: 0.54 ADSLadenylosuccinate lyase (ENSG00000239900), score: 0.51 ADSSL1adenylosuccinate synthase like 1 (ENSG00000185100), score: 0.5 AHCYL1adenosylhomocysteinase-like 1 (ENSG00000168710), score: -0.63 AICDAactivation-induced cytidine deaminase (ENSG00000111732), score: 0.74 ALDH6A1aldehyde dehydrogenase 6 family, member A1 (ENSG00000119711), score: 0.52 AMBRA1autophagy/beclin-1 regulator 1 (ENSG00000110497), score: 0.56 AMPD1adenosine monophosphate deaminase 1 (ENSG00000116748), score: 0.87 ANKRD1ankyrin repeat domain 1 (cardiac muscle) (ENSG00000148677), score: 0.53 AP1B1adaptor-related protein complex 1, beta 1 subunit (ENSG00000100280), score: 0.55 AP3S1adaptor-related protein complex 3, sigma 1 subunit (ENSG00000177879), score: -0.69 AP4E1adaptor-related protein complex 4, epsilon 1 subunit (ENSG00000081014), score: 0.53 APOBEC2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 (ENSG00000124701), score: 0.64 AQRaquarius homolog (mouse) (ENSG00000021776), score: 0.79 ARFGAP1ADP-ribosylation factor GTPase activating protein 1 (ENSG00000101199), score: -0.57 ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (ENSG00000124198), score: -0.63 ARL9ADP-ribosylation factor-like 9 (ENSG00000196503), score: 0.49 ASPNasporin (ENSG00000106819), score: 0.53 ATG16L1ATG16 autophagy related 16-like 1 (S. cerevisiae) (ENSG00000085978), score: 0.71 ATG4AATG4 autophagy related 4 homolog A (S. cerevisiae) (ENSG00000101844), score: 0.69 ATP1B4ATPase, Na+/K+ transporting, beta 4 polypeptide (ENSG00000101892), score: 0.83 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ENSG00000174437), score: 0.66 ATPAF2ATP synthase mitochondrial F1 complex assembly factor 2 (ENSG00000171953), score: 0.5 ATPIF1ATPase inhibitory factor 1 (ENSG00000130770), score: 0.51 B4GALT5UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 (ENSG00000158470), score: -0.56 BCKDHBbranched chain keto acid dehydrogenase E1, beta polypeptide (ENSG00000083123), score: 0.56 C10orf137chromosome 10 open reading frame 137 (ENSG00000107938), score: 0.49 C12orf45chromosome 12 open reading frame 45 (ENSG00000151131), score: 0.56 C12orf5chromosome 12 open reading frame 5 (ENSG00000078237), score: 0.65 C16orf68chromosome 16 open reading frame 68 (ENSG00000067365), score: 0.51 C17orf103chromosome 17 open reading frame 103 (ENSG00000154035), score: 0.51 C1orf123chromosome 1 open reading frame 123 (ENSG00000162384), score: 0.6 C1QTNF2C1q and tumor necrosis factor related protein 2 (ENSG00000145861), score: 0.53 C1QTNF7C1q and tumor necrosis factor related protein 7 (ENSG00000163145), score: 0.5 C6orf106chromosome 6 open reading frame 106 (ENSG00000196821), score: -0.6 C6orf186chromosome 6 open reading frame 186 (ENSG00000053328), score: 0.51 C6orf57chromosome 6 open reading frame 57 (ENSG00000154079), score: 0.67 C6orf89chromosome 6 open reading frame 89 (ENSG00000198663), score: 0.54 CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit (ENSG00000151067), score: 0.54 CCDC21coiled-coil domain containing 21 (ENSG00000130695), score: 0.51 CCDC28Acoiled-coil domain containing 28A (ENSG00000024862), score: -0.64 CCDC76coiled-coil domain containing 76 (ENSG00000122435), score: 0.49 CCND3cyclin D3 (ENSG00000112576), score: -0.53 CCNIcyclin I (ENSG00000118816), score: 0.56 CDK6cyclin-dependent kinase 6 (ENSG00000105810), score: 0.58 CFDP1craniofacial development protein 1 (ENSG00000153774), score: -0.54 CHPT1choline phosphotransferase 1 (ENSG00000111666), score: -0.54 CIAO1cytosolic iron-sulfur protein assembly 1 (ENSG00000144021), score: 0.5 CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (ENSG00000164442), score: 0.59 CLMNcalmin (calponin-like, transmembrane) (ENSG00000165959), score: -0.53 CLTCclathrin, heavy chain (Hc) (ENSG00000141367), score: -0.6 CMYA5cardiomyopathy associated 5 (ENSG00000164309), score: 0.64 COQ2coenzyme Q2 homolog, prenyltransferase (yeast) (ENSG00000173085), score: 0.51 COQ5coenzyme Q5 homolog, methyltransferase (S. cerevisiae) (ENSG00000110871), score: 0.49 COQ9coenzyme Q9 homolog (S. cerevisiae) (ENSG00000088682), score: 0.56 COX10COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (ENSG00000006695), score: 0.56 COX15COX15 homolog, cytochrome c oxidase assembly protein (yeast) (ENSG00000014919), score: 0.5 COX18COX18 cytochrome c oxidase assembly homolog (S. cerevisiae) (ENSG00000163626), score: 0.55 CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein) (ENSG00000129170), score: 0.58 CYSLTR1cysteinyl leukotriene receptor 1 (ENSG00000173198), score: 0.54 CYTH1cytohesin 1 (ENSG00000108669), score: -0.57 DAPP1dual adaptor of phosphotyrosine and 3-phosphoinositides (ENSG00000070190), score: 0.53 DCTN6dynactin 6 (ENSG00000104671), score: 0.56 DDR2discoidin domain receptor tyrosine kinase 2 (ENSG00000162733), score: 0.49 DLDdihydrolipoamide dehydrogenase (ENSG00000091140), score: 0.63 DLSTdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (ENSG00000119689), score: 0.53 DPH5DPH5 homolog (S. cerevisiae) (ENSG00000117543), score: 0.5 DPTdermatopontin (ENSG00000143196), score: 0.48 DUSP27dual specificity phosphatase 27 (putative) (ENSG00000198842), score: 0.65 EDNRAendothelin receptor type A (ENSG00000151617), score: 0.67 EHD4EH-domain containing 4 (ENSG00000103966), score: 0.53 EIF3Deukaryotic translation initiation factor 3, subunit D (ENSG00000100353), score: 0.62 EIF3Meukaryotic translation initiation factor 3, subunit M (ENSG00000149100), score: 0.48 ERCC6excision repair cross-complementing rodent repair deficiency, complementation group 6 (ENSG00000225830), score: -0.6 ERLIN2ER lipid raft associated 2 (ENSG00000147475), score: -0.58 FAM102Afamily with sequence similarity 102, member A (ENSG00000167106), score: -0.53 FAM54Bfamily with sequence similarity 54, member B (ENSG00000117640), score: 0.52 FAM82Bfamily with sequence similarity 82, member B (ENSG00000176623), score: 0.53 FBP2fructose-1,6-bisphosphatase 2 (ENSG00000130957), score: 0.73 FBXO32F-box protein 32 (ENSG00000156804), score: 0.55 FBXO40F-box protein 40 (ENSG00000163833), score: 0.66 FGF4fibroblast growth factor 4 (ENSG00000075388), score: 0.8 FGF6fibroblast growth factor 6 (ENSG00000111241), score: 0.74 FHfumarate hydratase (ENSG00000091483), score: 0.54 FHL2four and a half LIM domains 2 (ENSG00000115641), score: 0.6 FHL3four and a half LIM domains 3 (ENSG00000183386), score: 0.84 FSD2fibronectin type III and SPRY domain containing 2 (ENSG00000186628), score: 0.74 FYCO1FYVE and coiled-coil domain containing 1 (ENSG00000163820), score: 0.55 FZD4frizzled homolog 4 (Drosophila) (ENSG00000174804), score: 0.54 GANCglucosidase, alpha; neutral C (ENSG00000214013), score: 0.52 GARSglycyl-tRNA synthetase (ENSG00000106105), score: 0.51 GATA5GATA binding protein 5 (ENSG00000130700), score: 0.82 GATA6GATA binding protein 6 (ENSG00000141448), score: 0.58 GBGT1globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (ENSG00000148288), score: 0.49 GCNT7glucosaminyl (N-acetyl) transferase family member 7 (ENSG00000124091), score: 1 GJA3gap junction protein, alpha 3, 46kDa (ENSG00000121743), score: 0.73 GJD4gap junction protein, delta 4, 40.1kDa (ENSG00000177291), score: 0.55 GLTPD1glycolipid transfer protein domain containing 1 (ENSG00000224051), score: -0.59 GOT1glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) (ENSG00000120053), score: 0.5 GPN1GPN-loop GTPase 1 (ENSG00000198522), score: 0.54 GRAMD3GRAM domain containing 3 (ENSG00000155324), score: -0.56 GRXCR1glutaredoxin, cysteine rich 1 (ENSG00000215203), score: 0.71 GTPBP8GTP-binding protein 8 (putative) (ENSG00000163607), score: 0.74 GYG1glycogenin 1 (ENSG00000163754), score: 0.65 HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (ENSG00000084754), score: 0.56 HCCSholocytochrome c synthase (ENSG00000004961), score: 0.5 HIPK3homeodomain interacting protein kinase 3 (ENSG00000110422), score: 0.51 HMGXB4HMG box domain containing 4 (ENSG00000100281), score: 0.63 HOPXHOP homeobox (ENSG00000171476), score: 0.62 HTThuntingtin (ENSG00000197386), score: -0.58 IDEinsulin-degrading enzyme (ENSG00000119912), score: 0.53 IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha (ENSG00000166411), score: 0.53 IPO11importin 11 (ENSG00000086200), score: 0.5 IPPintracisternal A particle-promoted polypeptide (ENSG00000197429), score: 0.49 IQCB1IQ motif containing B1 (ENSG00000173226), score: -0.53 KBTBD10kelch repeat and BTB (POZ) domain containing 10 (ENSG00000239474), score: 0.53 KCNJ11potassium inwardly-rectifying channel, subfamily J, member 11 (ENSG00000187486), score: 0.56 KCNJ2potassium inwardly-rectifying channel, subfamily J, member 2 (ENSG00000123700), score: 0.77 KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1 (ENSG00000053918), score: 0.56 KHDRBS3KH domain containing, RNA binding, signal transduction associated 3 (ENSG00000131773), score: -0.64 KIAA0090KIAA0090 (ENSG00000127463), score: 0.56 KIAA0664KIAA0664 (ENSG00000132361), score: 0.5 KIAA0907KIAA0907 (ENSG00000132680), score: 0.51 KLHDC2kelch domain containing 2 (ENSG00000165516), score: 0.49 KLHL2kelch-like 2, Mayven (Drosophila) (ENSG00000109466), score: -0.53 KLHL31kelch-like 31 (Drosophila) (ENSG00000124743), score: 0.68 KLHL38kelch-like 38 (Drosophila) (ENSG00000175946), score: 0.63 KLHL5kelch-like 5 (Drosophila) (ENSG00000109790), score: -0.58 KREMEN1kringle containing transmembrane protein 1 (ENSG00000183762), score: 0.48 LBHlimb bud and heart development homolog (mouse) (ENSG00000213626), score: 0.54 LDB3LIM domain binding 3 (ENSG00000122367), score: 0.49 LMOD2leiomodin 2 (cardiac) (ENSG00000170807), score: 0.62 LOC100288211PPPDE peptidase domain containing 1 pseudogene (ENSG00000121644), score: 0.5 LOC100291405similar to protein tyrosine phosphatase-like A domain containing 1 (ENSG00000074696), score: -0.54 LOC100292202similar to solute carrier family 25, member 25 (ENSG00000148339), score: -0.54 LOC100294349similar to Parkinson disease 7 domain containing 1 (ENSG00000177225), score: 0.5 LPIN2lipin 2 (ENSG00000101577), score: -0.56 LRRC10leucine rich repeat containing 10 (ENSG00000198812), score: 0.91 LRRC14Bleucine rich repeat containing 14B (ENSG00000185028), score: 0.54 LRRC2leucine rich repeat containing 2 (ENSG00000163827), score: 0.52 LRRC20leucine rich repeat containing 20 (ENSG00000172731), score: 0.52 MAP1Dmethionine aminopeptidase 1D (ENSG00000172878), score: 0.48 MAP7microtubule-associated protein 7 (ENSG00000135525), score: -0.64 MCEEmethylmalonyl CoA epimerase (ENSG00000124370), score: 0.58 MDH2malate dehydrogenase 2, NAD (mitochondrial) (ENSG00000146701), score: 0.59 ME2malic enzyme 2, NAD(+)-dependent, mitochondrial (ENSG00000082212), score: -0.56 ME3malic enzyme 3, NADP(+)-dependent, mitochondrial (ENSG00000151376), score: 0.53 MEGF6multiple EGF-like-domains 6 (ENSG00000162591), score: 0.56 MEOX2mesenchyme homeobox 2 (ENSG00000106511), score: 0.61 MFN1mitofusin 1 (ENSG00000171109), score: 0.56 MRPL13mitochondrial ribosomal protein L13 (ENSG00000172172), score: 0.57 MRPL16mitochondrial ribosomal protein L16 (ENSG00000166902), score: 0.52 MRPL3mitochondrial ribosomal protein L3 (ENSG00000114686), score: 0.53 MRPS30mitochondrial ribosomal protein S30 (ENSG00000112996), score: 0.55 MYBPC3myosin binding protein C, cardiac (ENSG00000134571), score: 0.68 MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow (ENSG00000160808), score: 0.61 MYLIPmyosin regulatory light chain interacting protein (ENSG00000007944), score: 0.53 MYLK3myosin light chain kinase 3 (ENSG00000140795), score: 0.73 MYO6myosin VI (ENSG00000196586), score: -0.6 MYO9Bmyosin IXB (ENSG00000099331), score: -0.54 MYOM2myomesin (M-protein) 2, 165kDa (ENSG00000036448), score: 0.57 MYOTmyotilin (ENSG00000120729), score: 0.93 MYOZ2myozenin 2 (ENSG00000172399), score: 0.58 MYPNmyopalladin (ENSG00000138347), score: 0.51 NDUFA10NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa (ENSG00000130414), score: 0.65 NDUFA12NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 (ENSG00000184752), score: 0.68 NDUFA6NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa (ENSG00000184983), score: 0.7 NDUFA8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa (ENSG00000119421), score: 0.56 NDUFB10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa (ENSG00000140990), score: 0.61 NDUFS3NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) (ENSG00000213619), score: 0.79 NELFnasal embryonic LHRH factor (ENSG00000165802), score: -0.55 NIPSNAP1nipsnap homolog 1 (C. elegans) (ENSG00000184117), score: -0.61 NLRX1NLR family member X1 (ENSG00000160703), score: 0.49 NR4A3nuclear receptor subfamily 4, group A, member 3 (ENSG00000119508), score: 0.5 NT5C1A5'-nucleotidase, cytosolic IA (ENSG00000116981), score: 0.52 NT5C35'-nucleotidase, cytosolic III (ENSG00000122643), score: 0.58 NUP37nucleoporin 37kDa (ENSG00000075188), score: 0.53 OGDHoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (ENSG00000105953), score: 0.52 OXSR1oxidative-stress responsive 1 (ENSG00000172939), score: 0.64 PACS2phosphofurin acidic cluster sorting protein 2 (ENSG00000179364), score: -0.55 PACSIN3protein kinase C and casein kinase substrate in neurons 3 (ENSG00000165912), score: 0.53 PAMpeptidylglycine alpha-amidating monooxygenase (ENSG00000145730), score: 0.49 PARS2prolyl-tRNA synthetase 2, mitochondrial (putative) (ENSG00000162396), score: 0.52 PCBD2pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 (ENSG00000132570), score: 0.5 PCID2PCI domain containing 2 (ENSG00000126226), score: -0.57 PDE3Aphosphodiesterase 3A, cGMP-inhibited (ENSG00000172572), score: 0.58 PDHBpyruvate dehydrogenase (lipoamide) beta (ENSG00000168291), score: 0.69 PDK4pyruvate dehydrogenase kinase, isozyme 4 (ENSG00000004799), score: 0.52 PDLIM5PDZ and LIM domain 5 (ENSG00000163110), score: 0.58 PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (ENSG00000170525), score: -0.64 PHEXphosphate regulating endopeptidase homolog, X-linked (ENSG00000102174), score: 0.76 PHF5APHD finger protein 5A (ENSG00000100410), score: 0.74 PIGLphosphatidylinositol glycan anchor biosynthesis, class L (ENSG00000108474), score: 0.48 PITPNAphosphatidylinositol transfer protein, alpha (ENSG00000174238), score: -0.53 PLEKHA7pleckstrin homology domain containing, family A member 7 (ENSG00000166689), score: 0.52 PLNphospholamban (ENSG00000198523), score: 0.55 PPIP5K2diphosphoinositol pentakisphosphate kinase 2 (ENSG00000145725), score: 0.7 PPP1R3Dprotein phosphatase 1, regulatory (inhibitor) subunit 3D (ENSG00000132825), score: 0.74 PPPDE2PPPDE peptidase domain containing 2 (ENSG00000100418), score: 0.54 PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit (ENSG00000131791), score: 0.59 PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit (ENSG00000106617), score: 0.49 PTP4A2protein tyrosine phosphatase type IVA, member 2 (ENSG00000184007), score: 0.52 PTRFpolymerase I and transcript release factor (ENSG00000177469), score: 0.55 RAB11FIP4RAB11 family interacting protein 4 (class II) (ENSG00000131242), score: -0.54 RBM20RNA binding motif protein 20 (ENSG00000203867), score: 0.54 RBM24RNA binding motif protein 24 (ENSG00000112183), score: 0.61 RBM6RNA binding motif protein 6 (ENSG00000004534), score: -0.54 RBPJLrecombination signal binding protein for immunoglobulin kappa J region-like (ENSG00000124232), score: 0.58 RBPMS2RNA binding protein with multiple splicing 2 (ENSG00000166831), score: 0.59 RILPL1Rab interacting lysosomal protein-like 1 (ENSG00000188026), score: 0.57 RNF103ring finger protein 103 (ENSG00000239305), score: 0.61 RNF145ring finger protein 145 (ENSG00000145860), score: -0.62 RNF166ring finger protein 166 (ENSG00000158717), score: 0.52 RORARAR-related orphan receptor A (ENSG00000069667), score: -0.55 RPL3Lribosomal protein L3-like (ENSG00000140986), score: 0.51 RRADRas-related associated with diabetes (ENSG00000166592), score: 0.56 RTN4IP1reticulon 4 interacting protein 1 (ENSG00000130347), score: 0.75 SAP30LSAP30-like (ENSG00000164576), score: 0.49 SETD7SET domain containing (lysine methyltransferase) 7 (ENSG00000145391), score: -0.6 SFXN1sideroflexin 1 (ENSG00000164466), score: -0.64 SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (ENSG00000102683), score: 0.5 SH3YL1SH3 domain containing, Ysc84-like 1 (S. cerevisiae) (ENSG00000035115), score: -0.53 SIKE1suppressor of IKBKE 1 (ENSG00000052723), score: 0.49 SLAIN2SLAIN motif family, member 2 (ENSG00000109171), score: 0.49 SLC16A3solute carrier family 16, member 3 (monocarboxylic acid transporter 4) (ENSG00000141526), score: 0.49 SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 (ENSG00000075415), score: 0.73 SLC35B3solute carrier family 35, member B3 (ENSG00000124786), score: -0.63 SLC8A1solute carrier family 8 (sodium/calcium exchanger), member 1 (ENSG00000183023), score: 0.56 SMPXsmall muscle protein, X-linked (ENSG00000091482), score: 0.69 SMYD1SET and MYND domain containing 1 (ENSG00000115593), score: 0.62 SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) (ENSG00000172164), score: 0.51 SNX13sorting nexin 13 (ENSG00000071189), score: 0.59 SNX25sorting nexin 25 (ENSG00000109762), score: -0.6 SUCLG1succinate-CoA ligase, alpha subunit (ENSG00000163541), score: 0.49 SUPV3L1suppressor of var1, 3-like 1 (S. cerevisiae) (ENSG00000156502), score: 0.69 TBC1D16TBC1 domain family, member 16 (ENSG00000167291), score: 0.59 TBCEtubulin folding cofactor E (ENSG00000116957), score: 0.52 TBX20T-box 20 (ENSG00000164532), score: 0.73 TBX5T-box 5 (ENSG00000089225), score: 0.64 TCF12transcription factor 12 (ENSG00000140262), score: 0.55 TEAD4TEA domain family member 4 (ENSG00000197905), score: 0.51 TECRLtrans-2,3-enoyl-CoA reductase-like (ENSG00000205678), score: 0.64 TECTBtectorin beta (ENSG00000119913), score: 0.95 TIMM10translocase of inner mitochondrial membrane 10 homolog (yeast) (ENSG00000134809), score: 0.64 TIMM17Atranslocase of inner mitochondrial membrane 17 homolog A (yeast) (ENSG00000134375), score: 0.67 TIMM22translocase of inner mitochondrial membrane 22 homolog (yeast) (ENSG00000177370), score: 0.61 TLK1tousled-like kinase 1 (ENSG00000198586), score: -0.66 TMEM11transmembrane protein 11 (ENSG00000178307), score: 0.53 TMEM55Atransmembrane protein 55A (ENSG00000155099), score: -0.6 TMEM60transmembrane protein 60 (ENSG00000135211), score: 0.54 TMEM9transmembrane protein 9 (ENSG00000116857), score: -0.61 TMX4thioredoxin-related transmembrane protein 4 (ENSG00000125827), score: -0.54 TNFRSF21tumor necrosis factor receptor superfamily, member 21 (ENSG00000146072), score: -0.64 TNNC1troponin C type 1 (slow) (ENSG00000114854), score: 0.54 TNNT2troponin T type 2 (cardiac) (ENSG00000118194), score: 0.68 TOPORStopoisomerase I binding, arginine/serine-rich (ENSG00000197579), score: -0.6 TPH2tryptophan hydroxylase 2 (ENSG00000139287), score: 0.53 TRAF3TNF receptor-associated factor 3 (ENSG00000131323), score: -0.56 TRIM55tripartite motif-containing 55 (ENSG00000147573), score: 0.65 TRIM63tripartite motif-containing 63 (ENSG00000158022), score: 0.64 TRIM7tripartite motif-containing 7 (ENSG00000146054), score: 0.51 TRNAU1APtRNA selenocysteine 1 associated protein 1 (ENSG00000180098), score: 0.62 TRRAPtransformation/transcription domain-associated protein (ENSG00000196367), score: -0.65 TSG101tumor susceptibility gene 101 (ENSG00000074319), score: 0.69 TSR1TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) (ENSG00000167721), score: 0.5 TXLNBtaxilin beta (ENSG00000164440), score: 0.66 UCP3uncoupling protein 3 (mitochondrial, proton carrier) (ENSG00000175564), score: 0.58 UNC119unc-119 homolog (C. elegans) (ENSG00000109103), score: -0.53 UQCR11ubiquinol-cytochrome c reductase, complex III subunit XI (ENSG00000127540), score: 0.59 UQCRC1ubiquinol-cytochrome c reductase core protein I (ENSG00000010256), score: 0.55 UQCRC2ubiquinol-cytochrome c reductase core protein II (ENSG00000140740), score: 0.69 USP28ubiquitin specific peptidase 28 (ENSG00000048028), score: 0.53 WNT11wingless-type MMTV integration site family, member 11 (ENSG00000085741), score: 0.73 YIPF1Yip1 domain family, member 1 (ENSG00000058799), score: 0.57

Non-Entrez genes

Unknown, score:

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Id species tissue sex individual
oan_ht_f_ca1 oan ht f _
mdo_ht_m_ca1 mdo ht m _
oan_ht_m_ca1 oan ht m _
mdo_ht_f_ca1 mdo ht f _

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