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system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

all

NA

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

brush border

Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

sodium channel complex

An ion channel complex through which sodium ions pass.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

metallopeptidase activity

Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

exopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

peptidase activity, acting on L-amino acid peptides

Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

monovalent inorganic cation transmembrane transporter activity

Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

inorganic cation transmembrane transporter activity

Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

Id	Pvalue	ExpCount	Count	Size	Term
GO:0007588	1.327e-06	1.125	11 AQP3, ATP6V0A4, CLCN5, CLDN16, DAB2, KCNJ1, KCNK5, NPHS2, SCNN1A, SCNN1B, SCNN1G	24	excretion
GO:0006814	5.253e-06	2.203	14 ATP1B1, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A12, SLC5A9, SLC9A3, SLC9A4	47	sodium ion transport
GO:0015672	3.912e-05	5.249	20 ATP1B1, ATP6V0A4, ATP6V0D2, KCNJ1, KCNJ16, KCNK5, KCNQ1, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A12, SLC5A9, SLC9A3, SLC9A4	112	monovalent inorganic cation transport
GO:0006812	1.083e-04	10.69	29 ATP1B1, ATP6V0A4, ATP6V0D2, BSPRY, EGF, KCNJ1, KCNJ16, KCNK5, KCNQ1, PKD2, PLCG2, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A12, SLC5A9, SLC9A3, SLC9A4, TCN2, TRPM6, TRPV4	228	cation transport
GO:0055085	2.206e-04	13.03	32 ABCC4, AQP3, ATP6V0A4, ATP6V0D2, AXIN2, CDH1, CLCN5, EGF, KCNQ1, PKD2, PLCG2, RHCG, SFXN2, SLC13A1, SLC13A3, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC25A42, SLC2A9, SLC5A12, SLC5A9, SLC7A9, SLC9A3, SLC9A4, SMO, TRPM6, TRPV4	278	transmembrane transport
GO:0030001	2.249e-04	9.326	26 ATP1B1, BSPRY, EGF, KCNJ1, KCNJ16, KCNK5, KCNQ1, PKD2, PLCG2, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC34A1, SLC4A4, SLC5A12, SLC5A9, SLC9A3, SLC9A4, TCN2, TRPM6, TRPV4	199	metal ion transport
GO:0006811	1.039e-03	15.56	34 ABCC4, ATP1B1, ATP6V0A4, ATP6V0D2, BSPRY, CLCN5, CLDN16, EGF, KCNJ1, KCNJ16, KCNK5, KCNQ1, PKD2, PLCG2, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC17A5, SLC22A4, SLC22A7, SLC34A1, SLC4A4, SLC5A12, SLC5A9, SLC9A3, SLC9A4, TCN2, TRPM6, TRPV4	332	ion transport
GO:0009653	1.297e-02	23.48	41 AQP3, ARHGAP24, AXIN2, C22orf28, CASR, CCNE1, CDH1, COL4A3, CPM, CRYAA, CTSH, DAB2, EGF, ELF3, ENPEP, ERBB2, FOXI1, GATA3, HEY1, HNF1A, HOXA10, HOXB7, HOXD10, HOXD4, IGF1R, LMX1B, MYO6, NOX4, NTN4, PKD2, PLAT, PLAU, SMO, SPP1, TBX2, TFCP2L1, TIMP3, TINAG, TULP3, UPK3A, ZEB1	501	anatomical structure morphogenesis
GO:0006508	1.557e-02	12.51	26 ACE2, APEH, CPM, CTSH, DPEP1, DPP4, ENPEP, FBXO31, FBXW7, MEP1A, MEP1B, MMP7, OVCH2, PAPPA2, PEPD, PGPEP1, PLAT, PLAU, SCRN2, ST14, TIMP3, TINAG, TMEM27, TMPRSS2, TMPRSS4, XPNPEP2	267	proteolysis
GO:0015849	1.852e-02	3.234	11 HNF1A, SLC10A2, SLC13A3, SLC15A1, SLC16A4, SLC17A5, SLC22A4, SLC25A10, SLC3A1, SLC6A19, SLC7A9	69	organic acid transport
GO:0046942	1.852e-02	3.234	11 HNF1A, SLC10A2, SLC13A3, SLC15A1, SLC16A4, SLC17A5, SLC22A4, SLC25A10, SLC3A1, SLC6A19, SLC7A9	69	carboxylic acid transport
GO:0051179	2.340e-02	58.77	81 ABCC4, AFTPH, AQP3, ARSB, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, AXIN2, BSPRY, CDH1, CLCN5, CLDN16, CRYAA, CTSH, CUBN, CUX1, DAB2, DPP4, EGF, ELMO3, ENPEP, F2RL1, HNF1A, IGF1R, IGF2BP1, KCNJ1, KCNJ16, KCNK5, KCNQ1, LLGL2, LMX1B, MAL, MYO6, NPHS2, PICALM, PKD2, PLA2R1, PLAT, PLAU, PLCG2, PRLR, RAB11FIP3, RAB17, RAB38, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC25A42, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, SMO, SNX5, SNX6, TCN2, TMED6, TRPM6, TRPV4, UPK3A	1254	localization
GO:0051234	2.467e-02	50.75	72 ABCC4, AFTPH, AQP3, ARSB, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, AXIN2, BSPRY, CDH1, CLCN5, CLDN16, CRYAA, CUBN, CUX1, DAB2, DPP4, EGF, ELMO3, HNF1A, KCNJ1, KCNJ16, KCNK5, KCNQ1, LLGL2, MYO6, NPHS2, PICALM, PKD2, PLA2R1, PLCG2, PRLR, RAB11FIP3, RAB17, RAB38, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC25A42, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, SMO, SNX5, SNX6, TCN2, TMED6, TRPM6, TRPV4, UPK3A	1083	establishment of localization
GO:0006810	2.856e-02	50.19	71 ABCC4, AFTPH, AQP3, ARSB, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, AXIN2, BSPRY, CDH1, CLCN5, CLDN16, CRYAA, CUBN, CUX1, DAB2, EGF, ELMO3, HNF1A, KCNJ1, KCNJ16, KCNK5, KCNQ1, LLGL2, MYO6, NPHS2, PICALM, PKD2, PLA2R1, PLCG2, PRLR, RAB11FIP3, RAB17, RAB38, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC25A42, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, SMO, SNX5, SNX6, TCN2, TMED6, TRPM6, TRPV4, UPK3A	1071	transport
GO:0046903	2.879e-02	8.998	20 AQP3, ATP6V0A4, CLCN5, CLDN16, DAB2, EGF, HNF1A, KCNJ1, KCNK5, KCNQ1, LLGL2, MYO6, NPHS2, PRLR, SCIN, SCNN1A, SCNN1B, SCNN1G, SLC22A4, TRPV4	192	secretion
GO:0007584	3.649e-02	3.046	10 AQP3, ARSB, CCNE1, CTSH, CUBN, IGF1R, IGFBP7, SLC6A19, SPP1, TIMP3	65	response to nutrient
GO:0030879	4.936e-02	1.687	7 EGF, ELF3, ELF5, ERBB2, IGF1R, PRLR, TBX2	36	mammary gland development
GO:0031667	4.966e-02	4.358	12 AQP3, ARSB, CCNE1, CTSH, CUBN, HSD11B2, IGF1R, IGFBP7, NUAK2, SLC6A19, SPP1, TIMP3	93	response to nutrient levels

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	5.185e-15	3.479	27 AKR1A1, ATP1B1, ATP6V0A4, ATP6V0D2, CDH1, CLCN5, CUBN, DPEP1, DPP4, ENPEP, EPCAM, ERBB2, MAL, PLAT, PROM1, PROM2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC22A4, SLC5A12, SLC9A3, SLC9A4, TRPM6, UPK3A	75	apical part of cell
GO:0016324	1.246e-14	2.737	24 AKR1A1, ATP1B1, ATP6V0A4, ATP6V0D2, CUBN, DPEP1, DPP4, ENPEP, EPCAM, ERBB2, MAL, PROM1, PROM2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC22A4, SLC5A12, SLC9A3, SLC9A4, TRPM6, UPK3A	59	apical plasma membrane
GO:0005886	8.460e-06	52.56	87 ABCC4, ACE2, AKR1A1, ANKS4B, ANXA13, AQP3, ARHGAP24, ATP1B1, ATP6V0A4, ATP6V0D2, CASR, CDCP1, CDH1, CLCN5, CLDN16, CLDN19, CPM, CUBN, DPEP1, DPP4, EGF, ENPEP, EPCAM, ERBB2, F2RL1, GPR114, GPR160, GPR56, IGF1R, ILDR1, ITGB6, ITM2B, KCNJ1, KCNJ16, KCNK5, KCNQ1, KL, LAMP2, MAL, MEP1A, MEP1B, MPP5, MYO1D, MYO6, NOX4, NPHS2, PICALM, PKD2, PLA2R1, PLAU, PLCG2, PROM1, PROM2, PTPRE, RAB17, RAB38, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC22A4, SLC22A7, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, ST14, TM7SF3, TMPRSS2, TRPM6, TRPV4, TULP3, UPK3A, XPNPEP2	1133	plasma membrane
GO:0044459	1.107e-05	33.45	63 AKR1A1, AQP3, ARHGAP24, ATP1B1, ATP6V0A4, ATP6V0D2, CASR, CDH1, CLCN5, CLDN16, CLDN19, CUBN, DPEP1, DPP4, ENPEP, EPCAM, ERBB2, F2RL1, GPR56, IGF1R, ITGB6, KCNJ1, KCNJ16, KCNK5, KCNQ1, KL, MAL, MEP1A, MEP1B, MPP5, MYO1D, MYO6, NOX4, NPHS2, PICALM, PLA2R1, PROM1, PROM2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC15A1, SLC16A4, SLC17A5, SLC22A4, SLC22A7, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A12, SLC6A19, SLC7A9, SLC9A3, SLC9A4, ST14, TMPRSS2, TRPM6, TRPV4, UPK3A	721	plasma membrane part
GO:0031224	3.820e-05	75.01	110 A4GNT, ABCC4, ACE2, AQP3, ATP11A, ATP1B1, ATP6V0A4, B4GALNT3, CA12, CASR, CCDC90A, CDCP1, CDH1, CHPT1, CLCN5, CLDN16, CLDN19, CLPTM1L, COX15, CPM, CUX1, DGKE, DPEP1, DPP4, EGF, ENPEP, EPCAM, ERBB2, EVC, F2RL1, GALNT11, GALNT14, GCNT1, GLG1, GPR114, GPR160, GPR56, IGF1R, ILDR1, ITGB6, ITM2B, KCNJ1, KCNJ16, KCNK5, KCNQ1, KL, KLHDC7A, LAMP2, MAL, MEP1A, MEP1B, NOX4, NPHS2, PAQR5, PIGQ, PKD2, PLA2R1, PRLR, PROM1, PROM2, PTPRE, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC25A42, SLC2A9, SLC34A1, SLC3A1, SLC44A3, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, SMO, SPTLC3, ST14, ST6GALNAC2, SUSD2, SUSD3, TM2D2, TM7SF3, TMED6, TMEM171, TMEM27, TMEM51, TMIGD1, TMPRSS2, TMPRSS4, TRPM6, TRPV4, UPK3A, WLS, XPNPEP2, ZDHHC6	1617	intrinsic to membrane
GO:0016021	8.297e-05	73.48	107 A4GNT, ABCC4, ACE2, AQP3, ATP11A, ATP1B1, ATP6V0A4, B4GALNT3, CA12, CASR, CCDC90A, CDCP1, CDH1, CHPT1, CLCN5, CLDN16, CLDN19, CLPTM1L, COX15, CUX1, DGKE, DPP4, EGF, ENPEP, EPCAM, ERBB2, EVC, F2RL1, GALNT11, GALNT14, GCNT1, GLG1, GPR114, GPR160, GPR56, IGF1R, ILDR1, ITGB6, ITM2B, KCNJ1, KCNJ16, KCNK5, KCNQ1, KL, KLHDC7A, LAMP2, MAL, MEP1A, MEP1B, NOX4, NPHS2, PAQR5, PIGQ, PKD2, PLA2R1, PRLR, PROM1, PROM2, PTPRE, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC25A42, SLC2A9, SLC34A1, SLC3A1, SLC44A3, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, SMO, SPTLC3, ST14, ST6GALNAC2, SUSD2, SUSD3, TM2D2, TM7SF3, TMED6, TMEM171, TMEM27, TMEM51, TMIGD1, TMPRSS2, TMPRSS4, TRPM6, TRPV4, UPK3A, WLS, ZDHHC6	1584	integral to membrane
GO:0031253	1.297e-04	1.995	11 ATP6V0A4, CUBN, DPEP1, DPP4, MYO1D, MYO6, PROM1, PROM2, SLC34A1, SLC9A3, TRPM6	43	cell projection membrane
GO:0044425	3.338e-04	88.09	120 A4GNT, ABCC4, ACE2, AFTPH, AKR1A1, AQP3, ARHGAP24, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, B4GALNT3, CA12, CASR, CCDC90A, CDCP1, CDH1, CHPT1, CLCN5, CLDN16, CLDN19, CLPTM1L, COX15, CPM, CUBN, CUX1, DAB2, DGKE, DPEP1, DPP4, EGF, ENPEP, EPCAM, ERBB2, EVC, F2RL1, GALNT11, GALNT14, GCNT1, GLG1, GPR114, GPR160, GPR56, IGF1R, ILDR1, ITGB6, ITM2B, KCNJ1, KCNJ16, KCNK5, KCNQ1, KL, KLHDC7A, LAMP2, MAL, MEP1A, MEP1B, MPP5, MYO1D, MYO6, NOX4, NPHS2, PAQR5, PICALM, PIGQ, PKD2, PLA2R1, PRLR, PROM1, PROM2, PTPRE, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC25A42, SLC2A9, SLC34A1, SLC3A1, SLC44A3, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, SMO, SPTLC3, ST14, ST6GALNAC2, SUSD2, SUSD3, TM2D2, TM7SF3, TMED6, TMEM171, TMEM27, TMEM51, TMIGD1, TMPRSS2, TMPRSS4, TRPM6, TRPV4, UPK3A, WLS, XPNPEP2, ZDHHC6	1899	membrane part
GO:0005903	3.586e-04	0.835	7 ATP6V0A4, CUBN, ENPEP, SLC13A1, SLC34A1, SLC9A3, TRPM6	18	brush border
GO:0016020	1.008e-03	107.9	138 A4GNT, ABCC4, ACE2, ACPP, AFTPH, AKR1A1, ANKS4B, ANXA13, AQP3, ARHGAP24, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, B4GALNT3, BSPRY, CA12, CASR, CCDC90A, CDCP1, CDH1, CHPT1, CLCN5, CLDN16, CLDN19, CLPTM1L, COX15, CPM, CUBN, CUX1, DAB2, DGKE, DPEP1, DPP4, EGF, ENPEP, EPCAM, ERBB2, EVC, F2RL1, GALNT11, GALNT14, GCNT1, GLG1, GPR114, GPR160, GPR56, IGF1R, ILDR1, INVS, ITGB6, ITM2B, KCNJ1, KCNJ16, KCNK5, KCNQ1, KL, KLHDC7A, LAMP2, LDHD, MAL, MCCC1, MEP1A, MEP1B, MPP5, MYO1D, MYO6, NOX4, NPHS2, NPNT, PAPPA, PAPPA2, PAQR5, PICALM, PIGQ, PKD2, PLA2R1, PLAU, PLCG2, PRLR, PROM1, PROM2, PTPRE, RAB11FIP3, RAB17, RAB38, RHCG, RIPK4, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC25A42, SLC2A9, SLC34A1, SLC3A1, SLC44A3, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, SMO, SPTLC3, ST14, ST6GALNAC2, SUSD2, SUSD3, TFCP2L1, TM2D2, TM7SF3, TMED6, TMEM171, TMEM27, TMEM51, TMIGD1, TMPRSS2, TMPRSS4, TRPM6, TRPV4, TULP3, UPK3A, WLS, XPNPEP2, ZDHHC6	2327	membrane
GO:0016323	2.131e-03	4.268	14 AQP3, ARHGAP24, ATP1B1, CDH1, CLDN19, EPCAM, ERBB2, NOX4, PROM2, RHCG, SLC22A7, SLC4A4, SLC9A4, ST14	92	basolateral plasma membrane
GO:0034706	2.771e-03	0.1392	3 SCNN1A, SCNN1B, SCNN1G	3	sodium channel complex
GO:0031526	4.863e-03	0.6031	5 ATP6V0A4, CUBN, SLC34A1, SLC9A3, TRPM6	13	brush border membrane
GO:0005887	6.602e-03	19.16	35 ATP1B1, CASR, CLCN5, ENPEP, F2RL1, GPR56, IGF1R, ITGB6, KCNJ1, KCNJ16, KCNK5, KCNQ1, KL, MAL, MEP1A, MEP1B, NPHS2, PLA2R1, PROM1, RHCG, SCNN1G, SLC10A2, SLC15A1, SLC16A4, SLC17A5, SLC22A4, SLC22A7, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC6A19, SLC7A9, ST14, TMPRSS2	413	integral to plasma membrane
GO:0031226	9.470e-03	19.62	35 ATP1B1, CASR, CLCN5, ENPEP, F2RL1, GPR56, IGF1R, ITGB6, KCNJ1, KCNJ16, KCNK5, KCNQ1, KL, MAL, MEP1A, MEP1B, NPHS2, PLA2R1, PROM1, RHCG, SCNN1G, SLC10A2, SLC15A1, SLC16A4, SLC17A5, SLC22A4, SLC22A7, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC6A19, SLC7A9, ST14, TMPRSS2	423	intrinsic to plasma membrane
GO:0016471	3.308e-02	0.09278	2 ATP6V0A4, ATP6V0D2	2	vacuolar proton-transporting V-type ATPase complex
GO:0031088	3.308e-02	0.09278	2 ABCC4, LAMP2	2	platelet dense granule membrane
GO:0042827	3.308e-02	0.09278	2 ABCC4, LAMP2	2	platelet dense granule

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022804	5.766e-07	6.058	25 ABCC4, ATP11A, ATP1B1, ATP6V0A4, CLCN5, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4	130	active transmembrane transporter activity
GO:0022857	3.930e-06	17.15	43 ABCC4, AQP3, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, CLCN5, CLDN16, COX15, KCNJ1, KCNJ16, KCNK5, KCNQ1, MAL, PKD2, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, TRPM6, TRPV4	368	transmembrane transporter activity
GO:0022891	1.112e-05	15.94	40 ABCC4, AQP3, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, CLCN5, CLDN16, COX15, KCNJ1, KCNJ16, KCNK5, KCNQ1, PKD2, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, TRPM6, TRPV4	342	substrate-specific transmembrane transporter activity
GO:0015291	1.301e-05	3.914	18 CLCN5, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC22A4, SLC22A7, SLC2A9, SLC34A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC9A3, SLC9A4	84	secondary active transmembrane transporter activity
GO:0015293	4.341e-05	2.61	14 SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC22A4, SLC2A9, SLC34A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19	56	symporter activity
GO:0008324	9.973e-05	10.58	29 ATP1B1, ATP6V0A4, ATP6V0D2, CLDN16, COX15, KCNJ1, KCNJ16, KCNK5, KCNQ1, PKD2, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC17A5, SLC22A4, SLC2A9, SLC4A4, SLC5A9, SLC6A19, SLC9A3, SLC9A4, TRPM6, TRPV4	227	cation transmembrane transporter activity
GO:0015075	1.493e-04	13.98	34 ABCC4, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, CLCN5, CLDN16, COX15, KCNJ1, KCNJ16, KCNK5, KCNQ1, PKD2, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC17A5, SLC22A4, SLC22A7, SLC2A9, SLC34A1, SLC4A4, SLC5A9, SLC6A19, SLC9A3, SLC9A4, TRPM6, TRPV4	300	ion transmembrane transporter activity
GO:0070011	1.639e-04	7.969	24 ACE2, APEH, CPM, CTSH, DPEP1, DPP4, ENPEP, MEP1A, MEP1B, MMP7, OVCH2, PAPPA, PAPPA2, PEPD, PGPEP1, PLAT, PLAU, SCRN2, ST14, TINAG, TMEM27, TMPRSS2, TMPRSS4, XPNPEP2	171	peptidase activity, acting on L-amino acid peptides
GO:0022892	1.655e-04	18.08	40 ABCC4, AQP3, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, CLCN5, CLDN16, COX15, KCNJ1, KCNJ16, KCNK5, KCNQ1, PKD2, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, TRPM6, TRPV4	388	substrate-specific transporter activity
GO:0005215	2.202e-04	21.16	44 ABCC4, AQP3, ATP11A, ATP1B1, ATP6V0A4, ATP6V0D2, CLCN5, CLDN16, COX15, CUBN, KCNJ1, KCNJ16, KCNK5, KCNQ1, MAL, PKD2, RHCG, SCNN1A, SCNN1B, SCNN1G, SFXN2, SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC16A12, SLC16A4, SLC17A5, SLC18A1, SLC22A4, SLC22A7, SLC25A10, SLC2A9, SLC34A1, SLC3A1, SLC4A4, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SLC9A3, SLC9A4, TRPM6, TRPV4	454	transporter activity
GO:0022890	2.873e-04	3.588	15 ATP1B1, ATP6V0A4, ATP6V0D2, CLDN16, COX15, RHCG, SLC10A2, SLC13A1, SLC13A3, SLC22A4, SLC4A4, SLC5A9, SLC6A19, SLC9A3, SLC9A4	77	inorganic cation transmembrane transporter activity
GO:0008233	2.889e-04	8.295	24 ACE2, APEH, CPM, CTSH, DPEP1, DPP4, ENPEP, MEP1A, MEP1B, MMP7, OVCH2, PAPPA, PAPPA2, PEPD, PGPEP1, PLAT, PLAU, SCRN2, ST14, TINAG, TMEM27, TMPRSS2, TMPRSS4, XPNPEP2	178	peptidase activity
GO:0015077	9.814e-04	2.656	12 ATP1B1, ATP6V0A4, ATP6V0D2, COX15, SLC10A2, SLC13A1, SLC13A3, SLC4A4, SLC5A9, SLC6A19, SLC9A3, SLC9A4	57	monovalent inorganic cation transmembrane transporter activity
GO:0008237	2.302e-03	2.936	12 ACE2, CPM, DPEP1, ENPEP, MEP1A, MEP1B, MMP7, PAPPA, PAPPA2, PEPD, TMEM27, XPNPEP2	63	metallopeptidase activity
GO:0015294	2.459e-03	1.678	9 SLC10A2, SLC13A1, SLC13A3, SLC15A1, SLC17A5, SLC2A9, SLC4A4, SLC5A9, SLC6A19	36	solute:cation symporter activity
GO:0008238	2.920e-03	1.724	9 ACE2, CPM, DPEP1, DPP4, ENPEP, PEPD, SCRN2, TMEM27, XPNPEP2	37	exopeptidase activity
GO:0004252	1.074e-02	1.678	8 APEH, DPP4, OVCH2, PLAT, PLAU, ST14, TMPRSS2, TMPRSS4	36	serine-type endopeptidase activity
GO:0005342	1.680e-02	1.817	8 SLC10A2, SLC13A3, SLC16A4, SLC17A5, SLC25A10, SLC3A1, SLC6A19, SLC7A9	39	organic acid transmembrane transporter activity
GO:0046943	1.680e-02	1.817	8 SLC10A2, SLC13A3, SLC16A4, SLC17A5, SLC25A10, SLC3A1, SLC6A19, SLC7A9	39	carboxylic acid transmembrane transporter activity
GO:0004175	1.698e-02	4.94	14 APEH, CTSH, DPP4, MEP1A, MEP1B, MMP7, OVCH2, PAPPA, PLAT, PLAU, ST14, TINAG, TMPRSS2, TMPRSS4	106	endopeptidase activity
GO:0015280	1.820e-02	0.1864	3 SCNN1A, SCNN1B, SCNN1G	4	amiloride-sensitive sodium channel activity
GO:0016805	1.820e-02	0.1864	3 DPEP1, PEPD, SCRN2	4	dipeptidase activity
GO:0008236	2.502e-02	1.957	8 APEH, DPP4, OVCH2, PLAT, PLAU, ST14, TMPRSS2, TMPRSS4	42	serine-type peptidase activity
GO:0017171	2.502e-02	1.957	8 APEH, DPP4, OVCH2, PLAT, PLAU, ST14, TMPRSS2, TMPRSS4	42	serine hydrolase activity
GO:0015081	2.728e-02	1.538	7 ATP1B1, SLC10A2, SLC13A1, SLC13A3, SLC4A4, SLC5A9, SLC6A19	33	sodium ion transmembrane transporter activity
GO:0008235	3.942e-02	0.8388	5 CPM, DPEP1, ENPEP, PEPD, XPNPEP2	18	metalloexopeptidase activity
GO:0005272	4.114e-02	0.5126	4 PKD2, SCNN1A, SCNN1B, SCNN1G	11	sodium channel activity

Id	Pvalue	ExpCount	Count	Size	Term
04960	5.278e-03	0.8106	6 ATP1B1, HSD11B2, KCNJ1, SCNN1A, SCNN1B, SCNN1G	16	Aldosterone-regulated sodium reabsorption
04964	1.854e-02	0.4053	4 ATP1B1, SLC25A10, SLC4A4, SLC9A3	8	Proximal tubule bicarbonate reclamation

No enriched terms

No enriched terms

Entrez genes

A4GNTalpha-1,4-N-acetylglucosaminyltransferase (ENSG00000118017), score: 0.88 ABCC4ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ENSG00000125257), score: 0.62 ACE2angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ENSG00000130234), score: 0.66 ACMSDaminocarboxymuconate semialdehyde decarboxylase (ENSG00000153086), score: 0.6 ACO1aconitase 1, soluble (ENSG00000122729), score: 0.58 ACOT11acyl-CoA thioesterase 11 (ENSG00000162390), score: 0.59 ACPPacid phosphatase, prostate (ENSG00000014257), score: 0.74 AFTPHaftiphilin (ENSG00000119844), score: 0.5 AGPHD1aminoglycoside phosphotransferase domain containing 1 (ENSG00000188266), score: 0.58 AIM1absent in melanoma 1 (ENSG00000112297), score: 0.55 AKR1A1aldo-keto reductase family 1, member A1 (aldehyde reductase) (ENSG00000117448), score: 0.66 ALDH8A1aldehyde dehydrogenase 8 family, member A1 (ENSG00000118514), score: 0.54 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.56 ANXA13annexin A13 (ENSG00000104537), score: 0.65 APEHN-acylaminoacyl-peptide hydrolase (ENSG00000164062), score: 0.55 AQP3aquaporin 3 (Gill blood group) (ENSG00000165272), score: 0.67 ARHGAP24Rho GTPase activating protein 24 (ENSG00000138639), score: 0.71 ARSBarylsulfatase B (ENSG00000113273), score: 0.63 ATP11AATPase, class VI, type 11A (ENSG00000068650), score: 0.51 ATP1B1ATPase, Na+/K+ transporting, beta 1 polypeptide (ENSG00000143153), score: 0.5 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.8 ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (ENSG00000147614), score: 0.63 AXIN2axin 2 (ENSG00000168646), score: -0.53 B4GALNT3beta-1,4-N-acetyl-galactosaminyl transferase 3 (ENSG00000139044), score: 0.51 BNC2basonuclin 2 (ENSG00000173068), score: 0.72 BPHLbiphenyl hydrolase-like (serine hydrolase) (ENSG00000137274), score: 0.62 BPNT13'(2'), 5'-bisphosphate nucleotidase 1 (ENSG00000162813), score: 0.54 BSPRYB-box and SPRY domain containing (ENSG00000119411), score: 0.57 C11orf54chromosome 11 open reading frame 54 (ENSG00000182919), score: 0.73 C22orf28chromosome 22 open reading frame 28 (ENSG00000100220), score: 0.55 C9orf72chromosome 9 open reading frame 72 (ENSG00000147894), score: -0.5 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.82 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.81 CCDC90Acoiled-coil domain containing 90A (ENSG00000050393), score: 0.58 CCNE1cyclin E1 (ENSG00000105173), score: -0.53 CDCP1CUB domain containing protein 1 (ENSG00000163814), score: 0.57 CDH1cadherin 1, type 1, E-cadherin (epithelial) (ENSG00000039068), score: 0.5 CHPT1choline phosphotransferase 1 (ENSG00000111666), score: 0.51 CLCN5chloride channel 5 (ENSG00000171365), score: 0.53 CLDN16claudin 16 (ENSG00000113946), score: 0.84 CLDN19claudin 19 (ENSG00000164007), score: 0.64 CLPTM1LCLPTM1-like (ENSG00000049656), score: 0.5 CLYBLcitrate lyase beta like (ENSG00000125246), score: 0.56 COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (ENSG00000169031), score: 0.73 COL4A4collagen, type IV, alpha 4 (ENSG00000081052), score: 0.73 COX15COX15 homolog, cytochrome c oxidase assembly protein (yeast) (ENSG00000014919), score: 0.54 CPMcarboxypeptidase M (ENSG00000135678), score: 0.54 CRY1cryptochrome 1 (photolyase-like) (ENSG00000008405), score: -0.52 CRYAAcrystallin, alpha A (ENSG00000160202), score: 0.66 CRYL1crystallin, lambda 1 (ENSG00000165475), score: 0.63 CTSHcathepsin H (ENSG00000103811), score: 0.58 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.85 CUX1cut-like homeobox 1 (ENSG00000160967), score: 0.52 DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (ENSG00000153071), score: 0.72 DAOD-amino-acid oxidase (ENSG00000110887), score: 0.54 DARS2aspartyl-tRNA synthetase 2, mitochondrial (ENSG00000117593), score: 0.6 DDCdopa decarboxylase (aromatic L-amino acid decarboxylase) (ENSG00000132437), score: 0.71 DEPDC6DEP domain containing 6 (ENSG00000155792), score: 0.54 DGKEdiacylglycerol kinase, epsilon 64kDa (ENSG00000153933), score: -0.5 DPEP1dipeptidase 1 (renal) (ENSG00000015413), score: 0.75 DPP4dipeptidyl-peptidase 4 (ENSG00000197635), score: 0.58 DUSP10dual specificity phosphatase 10 (ENSG00000143507), score: -0.58 EGFepidermal growth factor (ENSG00000138798), score: 0.91 EHFets homologous factor (ENSG00000135373), score: 0.73 ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific ) (ENSG00000163435), score: 0.57 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.67 ELMO3engulfment and cell motility 3 (ENSG00000102890), score: 0.5 ENPEPglutamyl aminopeptidase (aminopeptidase A) (ENSG00000138792), score: 0.62 EPCAMepithelial cell adhesion molecule (ENSG00000119888), score: 0.66 ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ENSG00000141736), score: 0.5 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.79 EVCEllis van Creveld syndrome (ENSG00000072840), score: 0.7 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.78 FBXO31F-box protein 31 (ENSG00000103264), score: -0.57 FBXW7F-box and WD repeat domain containing 7 (ENSG00000109670), score: -0.5 FOXI1forkhead box I1 (ENSG00000168269), score: 0.8 FUCA2fucosidase, alpha-L- 2, plasma (ENSG00000001036), score: 0.76 GALNT11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) (ENSG00000178234), score: 0.72 GALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) (ENSG00000158089), score: 0.68 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.64 GCNT1glucosaminyl (N-acetyl) transferase 1, core 2 (ENSG00000187210), score: 0.51 GLB1galactosidase, beta 1 (ENSG00000170266), score: 0.66 GLG1golgi glycoprotein 1 (ENSG00000090863), score: 0.51 GPCPD1glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) (ENSG00000125772), score: -0.56 GPR114G protein-coupled receptor 114 (ENSG00000159618), score: 0.57 GPR160G protein-coupled receptor 160 (ENSG00000173890), score: 0.56 GPR56G protein-coupled receptor 56 (ENSG00000205336), score: 0.61 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.69 HAO2hydroxyacid oxidase 2 (long chain) (ENSG00000116882), score: 0.64 HECTD2HECT domain containing 2 (ENSG00000165338), score: -0.54 HEY1hairy/enhancer-of-split related with YRPW motif 1 (ENSG00000164683), score: -0.51 HNF1AHNF1 homeobox A (ENSG00000135100), score: 0.59 HNF4Ahepatocyte nuclear factor 4, alpha (ENSG00000101076), score: 0.58 HOXA10homeobox A10 (ENSG00000153807), score: 0.82 HOXB7homeobox B7 (ENSG00000120087), score: 0.78 HOXD10homeobox D10 (ENSG00000128710), score: 0.68 HOXD4homeobox D4 (ENSG00000170166), score: 0.74 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.72 IGF1Rinsulin-like growth factor 1 receptor (ENSG00000140443), score: 0.51 IGF2BP1insulin-like growth factor 2 mRNA binding protein 1 (ENSG00000159217), score: 0.55 IGFBP7insulin-like growth factor binding protein 7 (ENSG00000163453), score: 0.52 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.83 INVSinversin (ENSG00000119509), score: 0.52 ITGB6integrin, beta 6 (ENSG00000115221), score: 0.57 ITM2Bintegral membrane protein 2B (ENSG00000136156), score: 0.67 ITPKAinositol 1,4,5-trisphosphate 3-kinase A (ENSG00000137825), score: -0.49 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.92 KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (ENSG00000153822), score: 0.7 KCNK5potassium channel, subfamily K, member 5 (ENSG00000164626), score: 0.69 KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 1 (ENSG00000053918), score: 0.52 KIAA0100KIAA0100 (ENSG00000007202), score: 0.56 KIF12kinesin family member 12 (ENSG00000136883), score: 0.64 KLklotho (ENSG00000133116), score: 0.86 KLHDC7Akelch domain containing 7A (ENSG00000179023), score: 0.69 KRT80keratin 80 (ENSG00000167767), score: 0.58 LAD1ladinin 1 (ENSG00000159166), score: 0.65 LAMP2lysosomal-associated membrane protein 2 (ENSG00000005893), score: 0.54 LDHDlactate dehydrogenase D (ENSG00000166816), score: 0.54 LLGL2lethal giant larvae homolog 2 (Drosophila) (ENSG00000073350), score: 0.6 LMX1BLIM homeobox transcription factor 1, beta (ENSG00000136944), score: 0.6 LRRC20leucine rich repeat containing 20 (ENSG00000172731), score: -0.54 MALmal, T-cell differentiation protein (ENSG00000172005), score: 0.55 MCCC1methylcrotonoyl-CoA carboxylase 1 (alpha) (ENSG00000078070), score: 0.6 MEP1Ameprin A, alpha (PABA peptide hydrolase) (ENSG00000112818), score: 0.76 MEP1Bmeprin A, beta (ENSG00000141434), score: 0.77 METTL9methyltransferase like 9 (ENSG00000197006), score: 0.57 MMP7matrix metallopeptidase 7 (matrilysin, uterine) (ENSG00000137673), score: 0.59 MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) (ENSG00000072415), score: 0.57 MSRAmethionine sulfoxide reductase A (ENSG00000175806), score: 0.57 MYO1Dmyosin ID (ENSG00000176658), score: 0.51 MYO6myosin VI (ENSG00000196586), score: 0.71 NDRG4NDRG family member 4 (ENSG00000103034), score: -0.53 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.95 NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin) (ENSG00000116218), score: 0.79 NPNTnephronectin (ENSG00000168743), score: 0.72 NTN4netrin 4 (ENSG00000074527), score: 0.51 NUAK2NUAK family, SNF1-like kinase, 2 (ENSG00000163545), score: 0.69 NUDT19nudix (nucleoside diphosphate linked moiety X)-type motif 19 (ENSG00000213965), score: 0.52 OLFM4olfactomedin 4 (ENSG00000102837), score: 1 OVCH2ovochymase 2 (gene/pseudogene) (ENSG00000183378), score: 0.53 PAHphenylalanine hydroxylase (ENSG00000171759), score: 0.55 PAPPApregnancy-associated plasma protein A, pappalysin 1 (ENSG00000182752), score: 0.5 PAPPA2pappalysin 2 (ENSG00000116183), score: 0.67 PAQR5progestin and adipoQ receptor family member V (ENSG00000137819), score: 0.61 PEPDpeptidase D (ENSG00000124299), score: 0.7 PGPEP1pyroglutamyl-peptidase I (ENSG00000130517), score: 0.52 PICALMphosphatidylinositol binding clathrin assembly protein (ENSG00000073921), score: 0.62 PIGQphosphatidylinositol glycan anchor biosynthesis, class Q (ENSG00000007541), score: 0.57 PKD2polycystic kidney disease 2 (autosomal dominant) (ENSG00000118762), score: 0.67 PLA2R1phospholipase A2 receptor 1, 180kDa (ENSG00000153246), score: 0.54 PLATplasminogen activator, tissue (ENSG00000104368), score: 0.56 PLAUplasminogen activator, urokinase (ENSG00000122861), score: 0.73 PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific) (ENSG00000197943), score: 0.62 PLS1plastin 1 (ENSG00000120756), score: 0.56 PPA2pyrophosphatase (inorganic) 2 (ENSG00000138777), score: 0.53 PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit (ENSG00000111725), score: 0.59 PRLRprolactin receptor (ENSG00000113494), score: 0.55 PROM1prominin 1 (ENSG00000007062), score: 0.53 PROM2prominin 2 (ENSG00000155066), score: 0.69 PTPREprotein tyrosine phosphatase, receptor type, E (ENSG00000132334), score: -0.51 R3HDMLR3H domain containing-like (ENSG00000101074), score: 0.51 RAB11FIP3RAB11 family interacting protein 3 (class II) (ENSG00000090565), score: 0.69 RAB17RAB17, member RAS oncogene family (ENSG00000124839), score: 0.64 RAB38RAB38, member RAS oncogene family (ENSG00000123892), score: 0.62 RASSF6Ras association (RalGDS/AF-6) domain family member 6 (ENSG00000169435), score: 0.57 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.76 RIPK4receptor-interacting serine-threonine kinase 4 (ENSG00000183421), score: 0.53 RNF152ring finger protein 152 (ENSG00000176641), score: 0.54 RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (ENSG00000079102), score: -0.5 SACSspastic ataxia of Charlevoix-Saguenay (sacsin) (ENSG00000151835), score: -0.52 SCINscinderin (ENSG00000006747), score: 0.71 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.71 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.77 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.7 SCRN2secernin 2 (ENSG00000141295), score: 0.53 SFXN2sideroflexin 2 (ENSG00000156398), score: 0.5 SGK2serum/glucocorticoid regulated kinase 2 (ENSG00000101049), score: 0.6 SH3YL1SH3 domain containing, Ysc84-like 1 (S. cerevisiae) (ENSG00000035115), score: 0.56 SIM1single-minded homolog 1 (Drosophila) (ENSG00000112246), score: 0.59 SIM2single-minded homolog 2 (Drosophila) (ENSG00000159263), score: 0.87 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (ENSG00000125255), score: 0.77 SLC13A1solute carrier family 13 (sodium/sulfate symporters), member 1 (ENSG00000081800), score: 0.85 SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (ENSG00000158296), score: 0.7 SLC15A1solute carrier family 15 (oligopeptide transporter), member 1 (ENSG00000088386), score: 0.51 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.67 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.72 SLC17A5solute carrier family 17 (anion/sugar transporter), member 5 (ENSG00000119899), score: 0.58 SLC18A1solute carrier family 18 (vesicular monoamine), member 1 (ENSG00000036565), score: 0.53 SLC22A4solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (ENSG00000197208), score: 0.57 SLC22A7solute carrier family 22 (organic anion transporter), member 7 (ENSG00000137204), score: 0.52 SLC25A10solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 (ENSG00000183048), score: 0.57 SLC25A42solute carrier family 25, member 42 (ENSG00000181035), score: 0.57 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.58 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.82 SLC3A1solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 (ENSG00000138079), score: 0.69 SLC44A3solute carrier family 44, member 3 (ENSG00000143036), score: 0.54 SLC4A4solute carrier family 4, sodium bicarbonate cotransporter, member 4 (ENSG00000080493), score: 0.57 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.9 SLC5A9solute carrier family 5 (sodium/glucose cotransporter), member 9 (ENSG00000117834), score: 0.68 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.85 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.81 SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 3 (ENSG00000066230), score: 0.68 SLC9A4solute carrier family 9 (sodium/hydrogen exchanger), member 4 (ENSG00000180251), score: 0.73 SMOsmoothened homolog (Drosophila) (ENSG00000128602), score: 0.52 SNX29sorting nexin 29 (ENSG00000048471), score: 0.74 SNX5sorting nexin 5 (ENSG00000089006), score: 0.6 SNX6sorting nexin 6 (ENSG00000129515), score: 0.55 SOSTDC1sclerostin domain containing 1 (ENSG00000171243), score: 0.66 SPP1secreted phosphoprotein 1 (ENSG00000118785), score: 0.59 SPTLC3serine palmitoyltransferase, long chain base subunit 3 (ENSG00000172296), score: 0.52 ST14suppression of tumorigenicity 14 (colon carcinoma) (ENSG00000149418), score: 0.63 ST6GALNAC2ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ENSG00000070731), score: 0.5 STK32Bserine/threonine kinase 32B (ENSG00000152953), score: 0.72 SUMF1sulfatase modifying factor 1 (ENSG00000144455), score: 0.56 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.86 SUSD3sushi domain containing 3 (ENSG00000157303), score: 0.62 TBC1D1TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (ENSG00000065882), score: 0.55 TBC1D13TBC1 domain family, member 13 (ENSG00000107021), score: 0.6 TBX2T-box 2 (ENSG00000121068), score: 0.64 TCN2transcobalamin II (ENSG00000185339), score: 0.69 TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta) (ENSG00000008196), score: 0.53 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.88 THNSL2threonine synthase-like 2 (S. cerevisiae) (ENSG00000144115), score: 0.54 TIMP3TIMP metallopeptidase inhibitor 3 (ENSG00000100234), score: 0.53 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.75 TM2D2TM2 domain containing 2 (ENSG00000169490), score: 0.5 TM7SF3transmembrane 7 superfamily member 3 (ENSG00000064115), score: 0.67 TMED6transmembrane emp24 protein transport domain containing 6 (ENSG00000157315), score: 0.63 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.59 TMEM27transmembrane protein 27 (ENSG00000147003), score: 0.78 TMEM51transmembrane protein 51 (ENSG00000171729), score: 0.56 TMIGD1transmembrane and immunoglobulin domain containing 1 (ENSG00000182271), score: 0.73 TMPRSS2transmembrane protease, serine 2 (ENSG00000184012), score: 0.76 TMPRSS4transmembrane protease, serine 4 (ENSG00000137648), score: 0.68 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (ENSG00000145779), score: 0.55 TRPM6transient receptor potential cation channel, subfamily M, member 6 (ENSG00000119121), score: 0.54 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.83 TULP3tubby like protein 3 (ENSG00000078246), score: 0.51 UPK3Auroplakin 3A (ENSG00000100373), score: 0.53 WDR72WD repeat domain 72 (ENSG00000166415), score: 0.86 WDR91WD repeat domain 91 (ENSG00000105875), score: 0.55 WLSwntless homolog (Drosophila) (ENSG00000116729), score: 0.52 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.56 ZCCHC11zinc finger, CCHC domain containing 11 (ENSG00000134744), score: -0.52 ZDHHC6zinc finger, DHHC-type containing 6 (ENSG00000023041), score: 0.51 ZEB1zinc finger E-box binding homeobox 1 (ENSG00000148516), score: -0.5

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
ptr_kd_m_ca1	ptr	kd	m	_
ggo_kd_m_ca1	ggo	kd	m	_
mmu_kd_f_ca1	mmu	kd	f	_
mmu_kd_m2_ca1	mmu	kd	m	2
hsa_kd_f_ca1	hsa	kd	f	_
mmu_kd_m1_ca1	mmu	kd	m	1
hsa_kd_m2_ca1	hsa	kd	m	2
hsa_kd_m1_ca1	hsa	kd	m	1