Previous module | Next module Module #532, TG: 2, TC: 1.6, 143 probes, 143 Entrez genes, 10 conditions

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Expression data for module #532

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

neurological system process

A organ system process carried out by any of the organs or tissues of neurological system.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

signal transmission

The process whereby a signal is released and/or conveyed from one location to another.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

all

NA

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

Help | Hide | Top The GO tree — Cellular Components

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membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

synapse

The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

Help | Hide | Top The GO tree — Molecular Function

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

neurotransmitter binding

Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

No enriched terms

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif, 3 (ENSG00000156140), score: 0.66 ALX4ALX homeobox 4 (ENSG00000052850), score: 0.81 ANO3anoctamin 3 (ENSG00000134343), score: 0.66 ANXA1annexin A1 (ENSG00000135046), score: -0.62 ARFGAP2ADP-ribosylation factor GTPase activating protein 2 (ENSG00000149182), score: -0.67 ARFGAP3ADP-ribosylation factor GTPase activating protein 3 (ENSG00000242247), score: -0.56 ARPP21cAMP-regulated phosphoprotein, 21kDa (ENSG00000172995), score: 0.58 ARV1ARV1 homolog (S. cerevisiae) (ENSG00000173409), score: -0.59 ATP13A5ATPase type 13A5 (ENSG00000187527), score: 1 B3GALT1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 (ENSG00000172318), score: 0.6 B3GALT5UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (ENSG00000183778), score: 0.91 BAT2L2HLA-B associated transcript 2-like 2 (ENSG00000117523), score: 0.63 BCAT1branched chain amino-acid transaminase 1, cytosolic (ENSG00000060982), score: 0.59 BFSP2beaded filament structural protein 2, phakinin (ENSG00000170819), score: 0.64 BTBD8BTB (POZ) domain containing 8 (ENSG00000189195), score: 0.74 C14orf159chromosome 14 open reading frame 159 (ENSG00000133943), score: -0.56 C18orf22chromosome 18 open reading frame 22 (ENSG00000101546), score: -0.55 C18orf55chromosome 18 open reading frame 55 (ENSG00000075336), score: -0.58 C1orf43chromosome 1 open reading frame 43 (ENSG00000143612), score: -0.75 C20orf12chromosome 20 open reading frame 12 (ENSG00000089091), score: 0.64 C5orf24chromosome 5 open reading frame 24 (ENSG00000181904), score: 0.6 C6orf130chromosome 6 open reading frame 130 (ENSG00000124596), score: -0.65 C7orf16chromosome 7 open reading frame 16 (ENSG00000106341), score: 0.58 C7orf30chromosome 7 open reading frame 30 (ENSG00000156928), score: -0.62 C9orf4chromosome 9 open reading frame 4 (ENSG00000136805), score: 0.61 CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunit (ENSG00000198216), score: 0.6 CACNB4calcium channel, voltage-dependent, beta 4 subunit (ENSG00000182389), score: 0.6 CCDC51coiled-coil domain containing 51 (ENSG00000164051), score: -0.58 CDS2CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 (ENSG00000101290), score: 0.66 CHCHD8coiled-coil-helix-coiled-coil-helix domain containing 8 (ENSG00000181924), score: -0.71 CLVS1clavesin 1 (ENSG00000177182), score: 0.67 CNR1cannabinoid receptor 1 (brain) (ENSG00000118432), score: 0.58 CRTAPcartilage associated protein (ENSG00000170275), score: -0.59 CSMD2CUB and Sushi multiple domains 2 (ENSG00000121904), score: 0.77 CSRNP3cysteine-serine-rich nuclear protein 3 (ENSG00000178662), score: 0.58 D2HGDHD-2-hydroxyglutarate dehydrogenase (ENSG00000180902), score: -0.62 DGKIdiacylglycerol kinase, iota (ENSG00000157680), score: 0.76 DMP1dentin matrix acidic phosphoprotein 1 (ENSG00000152592), score: 0.81 DSCAMDown syndrome cell adhesion molecule (ENSG00000171587), score: 0.7 EN1engrailed homeobox 1 (ENSG00000163064), score: 0.68 EPHA3EPH receptor A3 (ENSG00000044524), score: 0.64 EPHA5EPH receptor A5 (ENSG00000145242), score: 0.61 ERAL1Era G-protein-like 1 (E. coli) (ENSG00000132591), score: -0.63 FAM105Afamily with sequence similarity 105, member A (ENSG00000145569), score: 0.59 FBXO7F-box protein 7 (ENSG00000100225), score: -0.59 FIP1L1FIP1 like 1 (S. cerevisiae) (ENSG00000145216), score: -0.56 FPGSfolylpolyglutamate synthase (ENSG00000136877), score: -0.57 GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 4 (ENSG00000109158), score: 0.63 GABRR2gamma-aminobutyric acid (GABA) receptor, rho 2 (ENSG00000111886), score: 0.86 GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (ENSG00000136750), score: 0.67 GALNTL6UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6 (ENSG00000174473), score: 0.61 GLRA1glycine receptor, alpha 1 (ENSG00000145888), score: 0.92 GPC5glypican 5 (ENSG00000179399), score: 0.69 GPR139G protein-coupled receptor 139 (ENSG00000180269), score: 0.82 GRIK1glutamate receptor, ionotropic, kainate 1 (ENSG00000171189), score: 0.69 GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B (ENSG00000150086), score: 0.58 GRIN3Aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A (ENSG00000198785), score: 0.74 GRM1glutamate receptor, metabotropic 1 (ENSG00000152822), score: 0.61 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (ENSG00000095951), score: 0.6 INPPL1inositol polyphosphate phosphatase-like 1 (ENSG00000165458), score: -0.58 KCNA10potassium voltage-gated channel, shaker-related subfamily, member 10 (ENSG00000143105), score: 0.65 KCNA3potassium voltage-gated channel, shaker-related subfamily, member 3 (ENSG00000177272), score: 0.58 KCNA6potassium voltage-gated channel, shaker-related subfamily, member 6 (ENSG00000151079), score: 0.68 KCNH7potassium voltage-gated channel, subfamily H (eag-related), member 7 (ENSG00000184611), score: 0.73 KCNJ6potassium inwardly-rectifying channel, subfamily J, member 6 (ENSG00000157542), score: 0.68 KCNK2potassium channel, subfamily K, member 2 (ENSG00000082482), score: 0.73 KERAkeratocan (ENSG00000139330), score: 0.68 KIAA0391KIAA0391 (ENSG00000100890), score: -0.64 KLHL11kelch-like 11 (Drosophila) (ENSG00000178502), score: 0.61 KRT9keratin 9 (ENSG00000171403), score: 0.66 LGALS3lectin, galactoside-binding, soluble, 3 (ENSG00000131981), score: -0.64 LGI2leucine-rich repeat LGI family, member 2 (ENSG00000153012), score: 0.64 LIN7Alin-7 homolog A (C. elegans) (ENSG00000111052), score: 0.59 LOC100291726similar to family with sequence similarity 70, member A (ENSG00000125355), score: 0.67 LOC100293817similar to hCG1811893 (ENSG00000144460), score: 0.62 LSM10LSM10, U7 small nuclear RNA associated (ENSG00000181817), score: -0.63 LSM4LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) (ENSG00000130520), score: -0.59 MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 (ENSG00000139915), score: 0.73 MRPL21mitochondrial ribosomal protein L21 (ENSG00000197345), score: -0.64 MYO16myosin XVI (ENSG00000041515), score: 0.83 MYOGmyogenin (myogenic factor 4) (ENSG00000122180), score: 0.74 NADSYN1NAD synthetase 1 (ENSG00000172890), score: -0.63 NDST4N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 (ENSG00000138653), score: 0.64 NFAT5nuclear factor of activated T-cells 5, tonicity-responsive (ENSG00000102908), score: 0.6 NFE2L2nuclear factor (erythroid-derived 2)-like 2 (ENSG00000116044), score: -0.71 NLGN1neuroligin 1 (ENSG00000169760), score: 0.59 NPY2Rneuropeptide Y receptor Y2 (ENSG00000185149), score: 0.71 OGG18-oxoguanine DNA glycosylase (ENSG00000114026), score: -0.66 OSTF1osteoclast stimulating factor 1 (ENSG00000134996), score: -0.55 PCSK2proprotein convertase subtilisin/kexin type 2 (ENSG00000125851), score: 0.58 PDE10Aphosphodiesterase 10A (ENSG00000112541), score: 0.67 PEX5Lperoxisomal biogenesis factor 5-like (ENSG00000114757), score: 0.59 POU1F1POU class 1 homeobox 1 (ENSG00000064835), score: 0.6 PPCSphosphopantothenoylcysteine synthetase (ENSG00000127125), score: -0.61 PQLC1PQ loop repeat containing 1 (ENSG00000122490), score: -0.57 PRCPprolylcarboxypeptidase (angiotensinase C) (ENSG00000137509), score: -0.6 PRKG2protein kinase, cGMP-dependent, type II (ENSG00000138669), score: 0.75 QARSglutaminyl-tRNA synthetase (ENSG00000172053), score: -0.6 RAB3GAP2RAB3 GTPase activating protein subunit 2 (non-catalytic) (ENSG00000118873), score: 0.59 RPAINRPA interacting protein (ENSG00000129197), score: -0.58 SCAMP1secretory carrier membrane protein 1 (ENSG00000085365), score: 0.59 SCG2secretogranin II (ENSG00000171951), score: 0.6 SDK2sidekick homolog 2 (chicken) (ENSG00000069188), score: 0.63 SEC31BSEC31 homolog B (S. cerevisiae) (ENSG00000075826), score: -0.64 SEMA3Asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A (ENSG00000075213), score: 0.82 SERTAD4SERTA domain containing 4 (ENSG00000082497), score: 0.6 SGSM1small G protein signaling modulator 1 (ENSG00000167037), score: 0.58 SLBPstem-loop binding protein (ENSG00000163950), score: -0.59 SLC25A37solute carrier family 25, member 37 (ENSG00000147454), score: -0.56 SLC32A1solute carrier family 32 (GABA vesicular transporter), member 1 (ENSG00000101438), score: 0.62 SLC39A12solute carrier family 39 (zinc transporter), member 12 (ENSG00000148482), score: 0.72 SLC4A10solute carrier family 4, sodium bicarbonate transporter, member 10 (ENSG00000144290), score: 0.59 SLC5A7solute carrier family 5 (choline transporter), member 7 (ENSG00000115665), score: 0.85 SLC6A11solute carrier family 6 (neurotransmitter transporter, GABA), member 11 (ENSG00000132164), score: 0.68 SLC7A14solute carrier family 7 (cationic amino acid transporter, y+ system), member 14 (ENSG00000013293), score: 0.67 SPRED1sprouty-related, EVH1 domain containing 1 (ENSG00000166068), score: 0.77 SRGAP3SLIT-ROBO Rho GTPase activating protein 3 (ENSG00000196220), score: 0.64 SRRM1serine/arginine repetitive matrix 1 (ENSG00000133226), score: 0.62 SSBP1single-stranded DNA binding protein 1 (ENSG00000106028), score: -0.57 SSNA1Sjogren syndrome nuclear autoantigen 1 (ENSG00000176101), score: -0.64 STXBP4syntaxin binding protein 4 (ENSG00000166263), score: 0.7 SV2Csynaptic vesicle glycoprotein 2C (ENSG00000122012), score: 0.69 SYNJ1synaptojanin 1 (ENSG00000159082), score: 0.61 TBC1D30TBC1 domain family, member 30 (ENSG00000111490), score: 0.7 THSD7Athrombospondin, type I, domain containing 7A (ENSG00000005108), score: 0.62 TLL1tolloid-like 1 (ENSG00000038295), score: 0.63 TMEM22transmembrane protein 22 (ENSG00000168917), score: 0.61 TNFRSF1Atumor necrosis factor receptor superfamily, member 1A (ENSG00000067182), score: -0.55 TRAM2translocation associated membrane protein 2 (ENSG00000065308), score: -0.61 TRPC3transient receptor potential cation channel, subfamily C, member 3 (ENSG00000138741), score: 0.71 TRPC5transient receptor potential cation channel, subfamily C, member 5 (ENSG00000072315), score: 0.61 TSHZ2teashirt zinc finger homeobox 2 (ENSG00000182463), score: 0.59 TSPAN2tetraspanin 2 (ENSG00000134198), score: 0.74 TXNDC16thioredoxin domain containing 16 (ENSG00000087301), score: 0.6 UBAP1ubiquitin associated protein 1 (ENSG00000165006), score: -0.66 UNC80unc-80 homolog (C. elegans) (ENSG00000144406), score: 0.62 USP45ubiquitin specific peptidase 45 (ENSG00000123552), score: 0.63 VTI1Avesicle transport through interaction with t-SNAREs homolog 1A (yeast) (ENSG00000151532), score: 0.64 WDFY3WD repeat and FYVE domain containing 3 (ENSG00000163625), score: 0.63 WNT4wingless-type MMTV integration site family, member 4 (ENSG00000162552), score: 0.6 WNT7Awingless-type MMTV integration site family, member 7A (ENSG00000154764), score: 0.62 ZFYVE21zinc finger, FYVE domain containing 21 (ENSG00000100711), score: -0.7 ZNF828zinc finger protein 828 (ENSG00000198824), score: 0.58

Non-Entrez genes

Unknown, score:

Help | Hide | Top Conditions

Id species tissue sex individual
mmu_cb_m2_ca1 mmu cb m 2
mmu_br_m2_ca1 mmu br m 2
mmu_cb_m1_ca1 mmu cb m 1
mmu_cb_f_ca1 mmu cb f _
mmu_br_f_ca1 mmu br f _
mmu_br_m1_ca1 mmu br m 1
gga_cb_m_ca1 gga cb m _
gga_cb_f_ca1 gga cb f _
gga_br_m_ca1 gga br m _
gga_br_f_ca1 gga br f _

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© 2008-2010 Computational Biology Group, Department of Medical Genetics, University of Lausanne, Switzerland