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Expression data for module #547

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

heart morphogenesis

The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

muscle system process

A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.

circulatory system process

A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.

heart process

A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

muscle contraction

A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

acetyl-CoA metabolic process

The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.

generation of precursor metabolites and energy

The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.

tricarboxylic acid cycle

A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

oxidation reduction

The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons.

respiratory electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

oxidative phosphorylation

The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

mitochondrial electron transport, NADH to ubiquinone

The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.

electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

coenzyme metabolic process

The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

oxidoreduction coenzyme metabolic process

The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed.

NADH metabolic process

The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.

nucleoside phosphate metabolic process

The chemical reactions and pathways involving any phosphorylated nucleoside.

phosphorus metabolic process

The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).

phosphate metabolic process

The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

striated muscle contraction

A process whereby force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.

blood circulation

The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

aerobic respiration

The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.

coenzyme catabolic process

The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

nucleotide metabolic process

The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

striated muscle tissue development

The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.

energy derivation by oxidation of organic compounds

The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

pyridine nucleotide metabolic process

The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.

NAD metabolic process

The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.

actin filament-based process

Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

actin-myosin filament sliding

The sliding movement of actin thin filaments and myosin thick filaments past each other.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

mitochondrial ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

cellular respiration

The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).

acetyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.

nicotinamide nucleotide metabolic process

The chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.

intracellular transport

The directed movement of substances within a cell.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue morphogenesis

The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

cofactor catabolic process

The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

cardiac muscle tissue morphogenesis

The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.

nucleobase, nucleoside and nucleotide metabolic process

The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.

heart contraction

The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

muscle tissue morphogenesis

The process by which the anatomical structures of muscle tissue are generated and organized. Muscle tissue consists of a set of cells that are part of an organ and carry out a contractive function. Morphogenesis pertains to the creation of form.

muscle tissue development

The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.

muscle structure development

The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.

actin-mediated cell contraction

The actin filament-based process by which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

intracellular transport

The directed movement of substances within a cell.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

cofactor catabolic process

The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein.

nucleobase, nucleoside and nucleotide metabolic process

The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.

actin-myosin filament sliding

The sliding movement of actin thin filaments and myosin thick filaments past each other.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue morphogenesis

The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

tissue morphogenesis

The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.

ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

coenzyme catabolic process

The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

heart contraction

The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

cardiac muscle tissue morphogenesis

The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.

heart morphogenesis

The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

muscle tissue development

The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

respiratory electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

oxidative phosphorylation

The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

acetyl-CoA catabolic process

The chemical reactions and pathways resulting in the breakdown of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated.

pyridine nucleotide metabolic process

The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.

cardiac muscle contraction

Muscle contraction of cardiac muscle tissue.

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

cardiac muscle tissue morphogenesis

The process by which the anatomical structures of cardiac muscle tissue are generated and organized. Morphogenesis pertains to the creation of form.

mitochondrial electron transport, NADH to ubiquinone

The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I.

tricarboxylic acid cycle

A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

mitochondrial envelope

The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.

mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

muscle myosin complex

A filament of myosin found in a muscle cell of any type.

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

myosin complex

A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.

myosin II complex

A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures.

sarcoplasm

The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.

sarcoplasmic reticulum

A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.

organelle inner membrane

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.

myofibril

The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

T-tubule

Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

NADH dehydrogenase complex

An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.

organelle membrane

The lipid bilayer surrounding an organelle.

A band

The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.

I band

A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

organelle envelope

A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.

envelope

A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

sarcolemma

The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

mitochondrial membrane part

Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

respiratory chain complex I

Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.

respiratory chain

The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

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NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

organelle envelope

A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

organelle envelope

A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.

organelle inner membrane

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.

NADH dehydrogenase complex

An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

NADH dehydrogenase complex

An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.

organelle inner membrane

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.

mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

mitochondrial membrane part

Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

mitochondrial envelope

The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

mitochondrial membrane part

Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

myosin complex

A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.

A band

The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.

I band

A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

respiratory chain complex I

Respiratory chain complex I is an enzyme of the respiratory chain. It consists of at least 34 polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.

muscle myosin complex

A filament of myosin found in a muscle cell of any type.

mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

sarcoplasmic reticulum

A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

T-tubule

Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.

sarcoplasmic reticulum

A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.

mitochondrial respiratory chain complex I

A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone.

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

myosin complex

A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes.

Help | Hide | Top The GO tree — Molecular Function

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

NADH dehydrogenase activity

Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.

structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

NADH dehydrogenase (ubiquinone) activity

Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.

structural constituent of muscle

The action of a molecule that contributes to the structural integrity of a muscle fiber.

oxidoreductase activity, acting on NADH or NADPH

Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule.

NADH dehydrogenase (quinone) activity

Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.

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NA

NADH dehydrogenase (quinone) activity

Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04260 1.007e-04 1.915 11
25 Cardiac muscle contraction
00190 1.046e-04 2.298 12
30 Oxidative phosphorylation
00020 2.692e-04 1.072 8
14 Citrate cycle (TCA cycle)
05010 1.143e-03 3.37 13
44 Alzheimer's disease
05012 1.305e-03 2.068 10
27 Parkinson's disease
05414 1.946e-03 2.604 11
34 Dilated cardiomyopathy
05412 4.062e-03 2.375 10
31 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
05410 8.251e-03 2.604 10
34 Hypertrophic cardiomyopathy (HCM)

Help | Hide | Top miRNA test for over-representation

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Help | Hide | Top Chromosome test for over-representation

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Entrez genes

ABCA12ATP-binding cassette, sub-family A (ABC1), member 12 (ENSG00000144452), score: 0.27 ABI3ABI family, member 3 (ENSG00000108798), score: 0.31 ABRAactin-binding Rho activating protein (ENSG00000174429), score: 0.4 ACER2alkaline ceramidase 2 (ENSG00000177076), score: 0.27 ACSL3acyl-CoA synthetase long-chain family member 3 (ENSG00000123983), score: -0.39 ACTN2actinin, alpha 2 (ENSG00000077522), score: 0.33 ADAM19ADAM metallopeptidase domain 19 (ENSG00000135074), score: 0.31 ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ENSG00000154736), score: 0.33 ADAMTSL5ADAMTS-like 5 (ENSG00000185761), score: 0.4 ADIPOR1adiponectin receptor 1 (ENSG00000159346), score: 0.32 AFAP1L1actin filament associated protein 1-like 1 (ENSG00000157510), score: 0.34 ALCAMactivated leukocyte cell adhesion molecule (ENSG00000170017), score: -0.3 AMOTL1angiomotin like 1 (ENSG00000166025), score: 0.29 ANAPC4anaphase promoting complex subunit 4 (ENSG00000053900), score: 0.31 ANGPT1angiopoietin 1 (ENSG00000154188), score: 0.43 ANGPTL2angiopoietin-like 2 (ENSG00000136859), score: 0.29 ANKRD1ankyrin repeat domain 1 (cardiac muscle) (ENSG00000148677), score: 0.36 ANKRD40ankyrin repeat domain 40 (ENSG00000154945), score: 0.27 ANO10anoctamin 10 (ENSG00000160746), score: 0.33 APBA3amyloid beta (A4) precursor protein-binding, family A, member 3 (ENSG00000011132), score: 0.34 APOBEC2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 (ENSG00000124701), score: 0.33 ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) (ENSG00000066777), score: 0.33 ARFIP2ADP-ribosylation factor interacting protein 2 (ENSG00000132254), score: -0.34 ARHGEF7Rho guanine nucleotide exchange factor (GEF) 7 (ENSG00000102606), score: 0.28 ARL6IP1ADP-ribosylation factor-like 6 interacting protein 1 (ENSG00000170540), score: -0.32 ARMC7armadillo repeat containing 7 (ENSG00000125449), score: -0.33 ART3ADP-ribosyltransferase 3 (ENSG00000156219), score: 0.37 ASB11ankyrin repeat and SOCS box-containing 11 (ENSG00000165192), score: 0.53 ASB14ankyrin repeat and SOCS box-containing 14 (ENSG00000239388), score: 0.43 ASB15ankyrin repeat and SOCS box-containing 15 (ENSG00000146809), score: 0.37 ASB2ankyrin repeat and SOCS box-containing 2 (ENSG00000100628), score: 0.38 ATG10ATG10 autophagy related 10 homolog (S. cerevisiae) (ENSG00000152348), score: 0.27 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ENSG00000174437), score: 0.5 ATP6V0A2ATPase, H+ transporting, lysosomal V0 subunit a2 (ENSG00000185344), score: 0.29 AVL9AVL9 homolog (S. cerevisiase) (ENSG00000105778), score: -0.32 BAG2BCL2-associated athanogene 2 (ENSG00000112208), score: 0.27 BAG3BCL2-associated athanogene 3 (ENSG00000151929), score: 0.3 BCL10B-cell CLL/lymphoma 10 (ENSG00000142867), score: 0.33 BEST3bestrophin 3 (ENSG00000127325), score: 0.34 BICD2bicaudal D homolog 2 (Drosophila) (ENSG00000185963), score: 0.3 BLKB lymphoid tyrosine kinase (ENSG00000136573), score: 0.37 BMP10bone morphogenetic protein 10 (ENSG00000163217), score: 0.36 C11orf74chromosome 11 open reading frame 74 (ENSG00000166352), score: 0.27 C12orf5chromosome 12 open reading frame 5 (ENSG00000078237), score: 0.32 C14orf1chromosome 14 open reading frame 1 (ENSG00000133935), score: -0.4 C16orf48chromosome 16 open reading frame 48 (ENSG00000124074), score: -0.29 C17orf39chromosome 17 open reading frame 39 (ENSG00000141034), score: 0.27 C1orf91chromosome 1 open reading frame 91 (ENSG00000160055), score: 0.28 C1QTNF6C1q and tumor necrosis factor related protein 6 (ENSG00000133466), score: 0.33 C20orf108chromosome 20 open reading frame 108 (ENSG00000124098), score: -0.3 C3orf26chromosome 3 open reading frame 26 (ENSG00000184220), score: 0.31 C3orf37chromosome 3 open reading frame 37 (ENSG00000183624), score: -0.33 C3orf75chromosome 3 open reading frame 75 (ENSG00000163832), score: -0.38 C6orf162chromosome 6 open reading frame 162 (ENSG00000111850), score: 0.32 C6orf72chromosome 6 open reading frame 72 (ENSG00000055211), score: 0.27 CABC1chaperone, ABC1 activity of bc1 complex homolog (S. pombe) (ENSG00000163050), score: 0.35 CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit (ENSG00000151067), score: 0.29 CACNA1Scalcium channel, voltage-dependent, L type, alpha 1S subunit (ENSG00000081248), score: 0.6 CADM1cell adhesion molecule 1 (ENSG00000182985), score: -0.47 CAND2cullin-associated and neddylation-dissociated 2 (putative) (ENSG00000144712), score: 0.29 CAPZBcapping protein (actin filament) muscle Z-line, beta (ENSG00000077549), score: 0.27 CBR4carbonyl reductase 4 (ENSG00000145439), score: 0.27 CCDC92coiled-coil domain containing 92 (ENSG00000119242), score: -0.35 CCRL1chemokine (C-C motif) receptor-like 1 (ENSG00000129048), score: 0.37 CD274CD274 molecule (ENSG00000120217), score: 0.36 CD28CD28 molecule (ENSG00000178562), score: 0.42 CDH2cadherin 2, type 1, N-cadherin (neuronal) (ENSG00000170558), score: 0.28 CDH5cadherin 5, type 2 (vascular endothelium) (ENSG00000179776), score: 0.3 CDK8cyclin-dependent kinase 8 (ENSG00000132964), score: 0.46 CENPFcentromere protein F, 350/400kDa (mitosin) (ENSG00000117724), score: 0.29 CEP68centrosomal protein 68kDa (ENSG00000011523), score: 0.32 CHRNA10cholinergic receptor, nicotinic, alpha 10 (ENSG00000129749), score: 0.45 CLIC4chloride intracellular channel 4 (ENSG00000169504), score: 0.28 CLIC5chloride intracellular channel 5 (ENSG00000112782), score: 0.27 CLIP1CAP-GLY domain containing linker protein 1 (ENSG00000130779), score: 0.33 CLIP4CAP-GLY domain containing linker protein family, member 4 (ENSG00000115295), score: 0.34 CLMNcalmin (calponin-like, transmembrane) (ENSG00000165959), score: -0.3 CMYA5cardiomyopathy associated 5 (ENSG00000164309), score: 0.33 CNSTconsortin, connexin sorting protein (ENSG00000162852), score: 0.36 COL15A1collagen, type XV, alpha 1 (ENSG00000204291), score: 0.28 COPB2coatomer protein complex, subunit beta 2 (beta prime) (ENSG00000184432), score: 0.28 COQ5coenzyme Q5 homolog, methyltransferase (S. cerevisiae) (ENSG00000110871), score: 0.36 COQ9coenzyme Q9 homolog (S. cerevisiae) (ENSG00000088682), score: 0.32 COX10COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (ENSG00000006695), score: 0.32 COX4I1cytochrome c oxidase subunit IV isoform 1 (ENSG00000131143), score: 0.32 CPEB3cytoplasmic polyadenylation element binding protein 3 (ENSG00000107864), score: 0.28 CPSF6cleavage and polyadenylation specific factor 6, 68kDa (ENSG00000111605), score: -0.29 CRATcarnitine O-acetyltransferase (ENSG00000095321), score: 0.29 CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein) (ENSG00000129170), score: 0.35 CTLA4cytotoxic T-lymphocyte-associated protein 4 (ENSG00000163599), score: 0.27 CWF19L1CWF19-like 1, cell cycle control (S. pombe) (ENSG00000095485), score: -0.33 CYTL1cytokine-like 1 (ENSG00000170891), score: 0.63 DAAM1dishevelled associated activator of morphogenesis 1 (ENSG00000100592), score: 0.31 DAPP1dual adaptor of phosphotyrosine and 3-phosphoinositides (ENSG00000070190), score: 0.39 DARS2aspartyl-tRNA synthetase 2, mitochondrial (ENSG00000117593), score: 0.28 DCP1BDCP1 decapping enzyme homolog B (S. cerevisiae) (ENSG00000151065), score: -0.28 DCUN1D2DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) (ENSG00000150401), score: 0.27 DCUN1D5DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) (ENSG00000137692), score: 0.27 DDOD-aspartate oxidase (ENSG00000203797), score: 0.29 DDX27DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (ENSG00000124228), score: -0.28 DDX41DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (ENSG00000183258), score: -0.33 DFNA5deafness, autosomal dominant 5 (ENSG00000105928), score: -0.29 DHCR2424-dehydrocholesterol reductase (ENSG00000116133), score: -0.3 DLDdihydrolipoamide dehydrogenase (ENSG00000091140), score: 0.3 DLSTdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (ENSG00000119689), score: 0.36 DNLZDNL-type zinc finger (ENSG00000213221), score: 0.27 DPY19L3dpy-19-like 3 (C. elegans) (ENSG00000178904), score: -0.31 DSG2desmoglein 2 (ENSG00000046604), score: 0.28 DSPdesmoplakin (ENSG00000096696), score: 0.37 DTNBP1dystrobrevin binding protein 1 (ENSG00000047579), score: 0.33 DUSP14dual specificity phosphatase 14 (ENSG00000161326), score: -0.41 DUSP27dual specificity phosphatase 27 (putative) (ENSG00000198842), score: 0.29 DYMdymeclin (ENSG00000141627), score: 0.36 EDNRAendothelin receptor type A (ENSG00000151617), score: 0.31 EEFSECeukaryotic elongation factor, selenocysteine-tRNA-specific (ENSG00000132394), score: -0.29 EGLN1egl nine homolog 1 (C. elegans) (ENSG00000135766), score: 0.46 EHD3EH-domain containing 3 (ENSG00000013016), score: -0.33 EHD4EH-domain containing 4 (ENSG00000103966), score: 0.45 ELTD1EGF, latrophilin and seven transmembrane domain containing 1 (ENSG00000162618), score: 0.27 EMILIN2elastin microfibril interfacer 2 (ENSG00000132205), score: 0.31 ENTPD4ectonucleoside triphosphate diphosphohydrolase 4 (ENSG00000197217), score: 0.38 EPB41L4Berythrocyte membrane protein band 4.1 like 4B (ENSG00000095203), score: -0.3 ERGv-ets erythroblastosis virus E26 oncogene homolog (avian) (ENSG00000157554), score: 0.26 ETFDHelectron-transferring-flavoprotein dehydrogenase (ENSG00000171503), score: 0.38 EXOC6exocyst complex component 6 (ENSG00000138190), score: 0.28 FAAHfatty acid amide hydrolase (ENSG00000117480), score: -0.42 FAF2Fas associated factor family member 2 (ENSG00000113194), score: -0.3 FAM160A1family with sequence similarity 160, member A1 (ENSG00000164142), score: 0.45 FAM174Bfamily with sequence similarity 174, member B (ENSG00000185442), score: 0.53 FAM179Afamily with sequence similarity 179, member A (ENSG00000189350), score: 0.28 FAM189A2family with sequence similarity 189, member A2 (ENSG00000135063), score: 0.36 FAM199Xfamily with sequence similarity 199, X-linked (ENSG00000123575), score: -0.29 FARS2phenylalanyl-tRNA synthetase 2, mitochondrial (ENSG00000145982), score: 0.35 FBLIM1filamin binding LIM protein 1 (ENSG00000162458), score: 0.37 FBP2fructose-1,6-bisphosphatase 2 (ENSG00000130957), score: 0.39 FBXL15F-box and leucine-rich repeat protein 15 (ENSG00000107872), score: -0.31 FBXO30F-box protein 30 (ENSG00000118496), score: 0.27 FBXO32F-box protein 32 (ENSG00000156804), score: 0.28 FBXO33F-box protein 33 (ENSG00000165355), score: -0.29 FBXO40F-box protein 40 (ENSG00000163833), score: 0.37 FBXO7F-box protein 7 (ENSG00000100225), score: -0.3 FBXW8F-box and WD repeat domain containing 8 (ENSG00000174989), score: 0.29 FEZ2fasciculation and elongation protein zeta 2 (zygin II) (ENSG00000171055), score: 0.32 FHfumarate hydratase (ENSG00000091483), score: 0.27 FHL2four and a half LIM domains 2 (ENSG00000115641), score: 0.33 FHOD3formin homology 2 domain containing 3 (ENSG00000134775), score: 0.29 FIG4FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae) (ENSG00000112367), score: 0.34 FILIP1filamin A interacting protein 1 (ENSG00000118407), score: 0.32 FITM2fat storage-inducing transmembrane protein 2 (ENSG00000197296), score: 0.35 FMR1fragile X mental retardation 1 (ENSG00000102081), score: -0.39 FN3KRPfructosamine 3 kinase related protein (ENSG00000141560), score: -0.31 FNDC5fibronectin type III domain containing 5 (ENSG00000160097), score: 0.28 FRMD6FERM domain containing 6 (ENSG00000139926), score: 0.35 FSD1Lfibronectin type III and SPRY domain containing 1-like (ENSG00000106701), score: 0.28 FSD2fibronectin type III and SPRY domain containing 2 (ENSG00000186628), score: 0.41 FUCA2fucosidase, alpha-L- 2, plasma (ENSG00000001036), score: 0.33 FYCO1FYVE and coiled-coil domain containing 1 (ENSG00000163820), score: 0.39 GAB1GRB2-associated binding protein 1 (ENSG00000109458), score: 0.3 GABRR2gamma-aminobutyric acid (GABA) receptor, rho 2 (ENSG00000111886), score: 0.3 GALNT1UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) (ENSG00000141429), score: 0.3 GCOM1GRINL1A complex locus (ENSG00000137878), score: 0.32 GFM2G elongation factor, mitochondrial 2 (ENSG00000164347), score: 0.27 GJA3gap junction protein, alpha 3, 46kDa (ENSG00000121743), score: 0.39 GMNNgeminin, DNA replication inhibitor (ENSG00000112312), score: 0.31 GNA12guanine nucleotide binding protein (G protein) alpha 12 (ENSG00000146535), score: 0.32 GNAI1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (ENSG00000127955), score: -0.32 GOLGA4golgin A4 (ENSG00000144674), score: 0.41 GPC1glypican 1 (ENSG00000063660), score: 0.32 GPCPD1glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) (ENSG00000125772), score: 0.3 GPR180G protein-coupled receptor 180 (ENSG00000152749), score: 0.29 GPX8glutathione peroxidase 8 (putative) (ENSG00000164294), score: 0.35 GRB14growth factor receptor-bound protein 14 (ENSG00000115290), score: 0.35 H1FXH1 histone family, member X (ENSG00000184897), score: -0.48 HADHAhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (ENSG00000084754), score: 0.37 HBP1HMG-box transcription factor 1 (ENSG00000105856), score: 0.29 HDDC2HD domain containing 2 (ENSG00000111906), score: -0.32 HEATR5AHEAT repeat containing 5A (ENSG00000129493), score: 0.31 HELBhelicase (DNA) B (ENSG00000127311), score: 0.27 HINFPhistone H4 transcription factor (ENSG00000172273), score: -0.31 HIPK3homeodomain interacting protein kinase 3 (ENSG00000110422), score: 0.42 HOPXHOP homeobox (ENSG00000171476), score: 0.27 HSPG2heparan sulfate proteoglycan 2 (ENSG00000142798), score: 0.28 IARS2isoleucyl-tRNA synthetase 2, mitochondrial (ENSG00000067704), score: 0.29 IDH3Aisocitrate dehydrogenase 3 (NAD+) alpha (ENSG00000166411), score: 0.37 IFFO1intermediate filament family orphan 1 (ENSG00000010295), score: -0.3 IGF2Rinsulin-like growth factor 2 receptor (ENSG00000197081), score: 0.3 IGHMBP2immunoglobulin mu binding protein 2 (ENSG00000132740), score: -0.3 IL10RBinterleukin 10 receptor, beta (ENSG00000243646), score: 0.4 IL12RB2interleukin 12 receptor, beta 2 (ENSG00000081985), score: 0.29 IL15interleukin 15 (ENSG00000164136), score: 0.38 INPP4Binositol polyphosphate-4-phosphatase, type II, 105kDa (ENSG00000109452), score: 0.27 IQCEIQ motif containing E (ENSG00000106012), score: -0.31 IVNS1ABPinfluenza virus NS1A binding protein (ENSG00000116679), score: 0.48 KBTBD10kelch repeat and BTB (POZ) domain containing 10 (ENSG00000239474), score: 0.31 KBTBD5kelch repeat and BTB (POZ) domain containing 5 (ENSG00000157119), score: 0.39 KCNA5potassium voltage-gated channel, shaker-related subfamily, member 5 (ENSG00000130037), score: 0.32 KCNJ11potassium inwardly-rectifying channel, subfamily J, member 11 (ENSG00000187486), score: 0.27 KCNJ2potassium inwardly-rectifying channel, subfamily J, member 2 (ENSG00000123700), score: 0.29 KCNJ5potassium inwardly-rectifying channel, subfamily J, member 5 (ENSG00000120457), score: 0.48 KCNK1potassium channel, subfamily K, member 1 (ENSG00000135750), score: -0.31 KCNV2potassium channel, subfamily V, member 2 (ENSG00000168263), score: 0.68 KDRkinase insert domain receptor (a type III receptor tyrosine kinase) (ENSG00000128052), score: 0.29 KIAA0100KIAA0100 (ENSG00000007202), score: 0.36 KIAA0232KIAA0232 (ENSG00000170871), score: 0.28 KIAA0368KIAA0368 (ENSG00000136813), score: 0.29 KIAA1614KIAA1614 (ENSG00000135835), score: 0.29 KIF13Akinesin family member 13A (ENSG00000137177), score: 0.4 KLHDC1kelch domain containing 1 (ENSG00000197776), score: 0.33 KLHL21kelch-like 21 (Drosophila) (ENSG00000162413), score: 0.26 KLHL24kelch-like 24 (Drosophila) (ENSG00000114796), score: 0.38 KLHL31kelch-like 31 (Drosophila) (ENSG00000124743), score: 0.27 KLHL38kelch-like 38 (Drosophila) (ENSG00000175946), score: 0.31 KREMEN1kringle containing transmembrane protein 1 (ENSG00000183762), score: 0.32 LACE1lactation elevated 1 (ENSG00000135537), score: 0.34 LAMA4laminin, alpha 4 (ENSG00000112769), score: 0.3 LAMB2laminin, beta 2 (laminin S) (ENSG00000172037), score: 0.29 LBHlimb bud and heart development homolog (mouse) (ENSG00000213626), score: 0.34 LCLAT1lysocardiolipin acyltransferase 1 (ENSG00000172954), score: 0.42 LDB3LIM domain binding 3 (ENSG00000122367), score: 0.32 LMOD2leiomodin 2 (cardiac) (ENSG00000170807), score: 0.37 LMOD3leiomodin 3 (fetal) (ENSG00000163380), score: 0.57 LOC100131693eukaryotic translation initiation factor 4E pseudogene (ENSG00000151247), score: 0.37 LOC100291671similar to SH3-binding domain and glutamic acid-rich protein (ENSG00000185437), score: 0.32 LRRC10leucine rich repeat containing 10 (ENSG00000198812), score: 0.45 LRRC14Bleucine rich repeat containing 14B (ENSG00000185028), score: 0.28 LRRC15leucine rich repeat containing 15 (ENSG00000172061), score: 0.48 LRRC2leucine rich repeat containing 2 (ENSG00000163827), score: 0.41 LRRC39leucine rich repeat containing 39 (ENSG00000122477), score: 0.38 LRRC40leucine rich repeat containing 40 (ENSG00000066557), score: -0.29 LRRC8Cleucine rich repeat containing 8 family, member C (ENSG00000171488), score: 0.27 LRTM1leucine-rich repeats and transmembrane domains 1 (ENSG00000144771), score: 1 LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (ENSG00000160285), score: -0.45 LYPLAL1lysophospholipase-like 1 (ENSG00000143353), score: -0.32 LZICleucine zipper and CTNNBIP1 domain containing (ENSG00000162441), score: 0.36 MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 3 (ENSG00000081026), score: 0.29 MAP1Dmethionine aminopeptidase 1D (ENSG00000172878), score: 0.38 MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha (ENSG00000101460), score: 0.38 MAP3K15mitogen-activated protein kinase kinase kinase 15 (ENSG00000180815), score: 0.27 MAP3K4mitogen-activated protein kinase kinase kinase 4 (ENSG00000085511), score: 0.32 MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2 (ENSG00000162889), score: 0.28 MAPKSP1MAPK scaffold protein 1 (ENSG00000109270), score: 0.35 MARCH5membrane-associated ring finger (C3HC4) 5 (ENSG00000198060), score: 0.32 MCCC1methylcrotonoyl-CoA carboxylase 1 (alpha) (ENSG00000078070), score: 0.29 MCM3APminichromosome maintenance complex component 3 associated protein (ENSG00000160294), score: -0.28 MDH1malate dehydrogenase 1, NAD (soluble) (ENSG00000014641), score: 0.31 MDH2malate dehydrogenase 2, NAD (mitochondrial) (ENSG00000146701), score: 0.35 MEAF6MYST/Esa1-associated factor 6 (ENSG00000163875), score: -0.39 MEOX2mesenchyme homeobox 2 (ENSG00000106511), score: 0.28 MFN1mitofusin 1 (ENSG00000171109), score: 0.47 MFN2mitofusin 2 (ENSG00000116688), score: 0.38 MFSD2Amajor facilitator superfamily domain containing 2A (ENSG00000168389), score: -0.29 MGRN1mahogunin, ring finger 1 (ENSG00000102858), score: 0.27 MMAAmethylmalonic aciduria (cobalamin deficiency) cblA type (ENSG00000151611), score: 0.28 MOV10L1Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) (ENSG00000073146), score: 0.41 MRPL51mitochondrial ribosomal protein L51 (ENSG00000111639), score: 0.32 MRPS23mitochondrial ribosomal protein S23 (ENSG00000181610), score: 0.38 MRPS35mitochondrial ribosomal protein S35 (ENSG00000061794), score: 0.29 MSGN1mesogenin 1 (ENSG00000151379), score: 0.29 MSH6mutS homolog 6 (E. coli) (ENSG00000116062), score: -0.29 MURCmuscle-related coiled-coil protein (ENSG00000170681), score: 0.39 MVDmevalonate (diphospho) decarboxylase (ENSG00000167508), score: -0.3 MYBPC3myosin binding protein C, cardiac (ENSG00000134571), score: 0.36 MYL1myosin, light chain 1, alkali; skeletal, fast (ENSG00000168530), score: 0.57 MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow (ENSG00000160808), score: 0.35 MYL4myosin, light chain 4, alkali; atrial, embryonic (ENSG00000198336), score: 0.36 MYLK3myosin light chain kinase 3 (ENSG00000140795), score: 0.44 MYLK4myosin light chain kinase family, member 4 (ENSG00000145949), score: 0.64 MYOCDmyocardin (ENSG00000141052), score: 0.45 MYOM2myomesin (M-protein) 2, 165kDa (ENSG00000036448), score: 0.31 MYOTmyotilin (ENSG00000120729), score: 0.33 MYOZ2myozenin 2 (ENSG00000172399), score: 0.37 MYPNmyopalladin (ENSG00000138347), score: 0.4 NAA35N(alpha)-acetyltransferase 35, NatC auxiliary subunit (ENSG00000135040), score: 0.35 NDUFA10NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa (ENSG00000130414), score: 0.36 NDUFA6NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa (ENSG00000184983), score: 0.3 NDUFA8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa (ENSG00000119421), score: 0.38 NDUFB10NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa (ENSG00000140990), score: 0.34 NDUFB9NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa (ENSG00000147684), score: 0.36 NDUFS3NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) (ENSG00000213619), score: 0.27 NECAB3N-terminal EF-hand calcium binding protein 3 (ENSG00000125967), score: -0.34 NEDD4neural precursor cell expressed, developmentally down-regulated 4 (ENSG00000069869), score: 0.42 NEK6NIMA (never in mitosis gene a)-related kinase 6 (ENSG00000119408), score: -0.31 NEK9NIMA (never in mitosis gene a)- related kinase 9 (ENSG00000119638), score: 0.36 NIPSNAP1nipsnap homolog 1 (C. elegans) (ENSG00000184117), score: -0.41 NRAPnebulin-related anchoring protein (ENSG00000197893), score: 0.28 NRTNneurturin (ENSG00000171119), score: 0.27 NSL1NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) (ENSG00000117697), score: -0.37 NSMAFneutral sphingomyelinase (N-SMase) activation associated factor (ENSG00000035681), score: 0.39 OGDHoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (ENSG00000105953), score: 0.47 OXNAD1oxidoreductase NAD-binding domain containing 1 (ENSG00000154814), score: 0.35 PALB2partner and localizer of BRCA2 (ENSG00000083093), score: -0.29 PAMpeptidylglycine alpha-amidating monooxygenase (ENSG00000145730), score: 0.34 PCGF5polycomb group ring finger 5 (ENSG00000180628), score: 0.36 PCYT1Aphosphate cytidylyltransferase 1, choline, alpha (ENSG00000161217), score: 0.3 PDCD5programmed cell death 5 (ENSG00000105185), score: 0.28 PDHBpyruvate dehydrogenase (lipoamide) beta (ENSG00000168291), score: 0.41 PDLIM5PDZ and LIM domain 5 (ENSG00000163110), score: 0.27 PDRG1p53 and DNA-damage regulated 1 (ENSG00000088356), score: 0.32 PEMTphosphatidylethanolamine N-methyltransferase (ENSG00000133027), score: -0.31 PFDN1prefoldin subunit 1 (ENSG00000113068), score: 0.28 PHTF2putative homeodomain transcription factor 2 (ENSG00000006576), score: 0.58 PIGPphosphatidylinositol glycan anchor biosynthesis, class P (ENSG00000185808), score: 0.37 PLAAphospholipase A2-activating protein (ENSG00000137055), score: 0.27 PLCE1phospholipase C, epsilon 1 (ENSG00000138193), score: 0.27 PLEKHN1pleckstrin homology domain containing, family N member 1 (ENSG00000187583), score: 0.3 PLNphospholamban (ENSG00000198523), score: 0.38 PM20D2peptidase M20 domain containing 2 (ENSG00000146281), score: 0.33 POFUT2protein O-fucosyltransferase 2 (ENSG00000186866), score: 0.29 PPIP5K2diphosphoinositol pentakisphosphate kinase 2 (ENSG00000145725), score: 0.33 PPM1Bprotein phosphatase, Mg2+/Mn2+ dependent, 1B (ENSG00000138032), score: 0.28 PPP1R14Cprotein phosphatase 1, regulatory (inhibitor) subunit 14C (ENSG00000198729), score: 0.29 PPP1R3Aprotein phosphatase 1, regulatory (inhibitor) subunit 3A (ENSG00000154415), score: 0.42 PPPDE2PPPDE peptidase domain containing 2 (ENSG00000100418), score: -0.31 PPTC7PTC7 protein phosphatase homolog (S. cerevisiae) (ENSG00000196850), score: 0.32 PRPF19PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) (ENSG00000110107), score: 0.34 PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (ENSG00000197170), score: 0.36 PSME4proteasome (prosome, macropain) activator subunit 4 (ENSG00000068878), score: 0.33 PSTPIP2proline-serine-threonine phosphatase interacting protein 2 (ENSG00000152229), score: 0.35 PTGR2prostaglandin reductase 2 (ENSG00000140043), score: 0.36 PTPLAD2protein tyrosine phosphatase-like A domain containing 2 (ENSG00000188921), score: 0.3 PTPN11protein tyrosine phosphatase, non-receptor type 11 (ENSG00000179295), score: 0.37 QSER1glutamine and serine rich 1 (ENSG00000060749), score: 0.31 RAB11FIP4RAB11 family interacting protein 4 (class II) (ENSG00000131242), score: -0.3 RAB22ARAB22A, member RAS oncogene family (ENSG00000124209), score: 0.33 RAB4ARAB4A, member RAS oncogene family (ENSG00000168118), score: -0.32 RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic) (ENSG00000188559), score: 0.4 RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (ENSG00000173166), score: 0.33 RAPSNreceptor-associated protein of the synapse (ENSG00000165917), score: 0.54 RBM14RNA binding motif protein 14 (ENSG00000239306), score: -0.31 RBM20RNA binding motif protein 20 (ENSG00000203867), score: 0.32 RBM24RNA binding motif protein 24 (ENSG00000112183), score: 0.34 RDM1RAD52 motif 1 (ENSG00000187456), score: 0.33 REPS2RALBP1 associated Eps domain containing 2 (ENSG00000169891), score: -0.29 RGS5regulator of G-protein signaling 5 (ENSG00000143248), score: 0.28 RHOT2ras homolog gene family, member T2 (ENSG00000140983), score: 0.31 RHPN1rhophilin, Rho GTPase binding protein 1 (ENSG00000158106), score: -0.28 RILPL1Rab interacting lysosomal protein-like 1 (ENSG00000188026), score: 0.29 RNF139ring finger protein 139 (ENSG00000170881), score: 0.42 ROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila) (ENSG00000169855), score: -0.29 ROCK2Rho-associated, coiled-coil containing protein kinase 2 (ENSG00000134318), score: 0.28 RPL3Lribosomal protein L3-like (ENSG00000140986), score: 0.37 RTN4IP1reticulon 4 interacting protein 1 (ENSG00000130347), score: 0.29 RYR2ryanodine receptor 2 (cardiac) (ENSG00000198626), score: 0.32 SAP30BPSAP30 binding protein (ENSG00000161526), score: -0.32 SCUBE2signal peptide, CUB domain, EGF-like 2 (ENSG00000175356), score: 0.35 SEL1L3sel-1 suppressor of lin-12-like 3 (C. elegans) (ENSG00000091490), score: -0.31 SERINC3serine incorporator 3 (ENSG00000132824), score: 0.31 SESN1sestrin 1 (ENSG00000080546), score: 0.36 SFMBT2Scm-like with four mbt domains 2 (ENSG00000198879), score: -0.32 SGCBsarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (ENSG00000163069), score: 0.36 SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (ENSG00000102683), score: 0.43 SGSM3small G protein signaling modulator 3 (ENSG00000100359), score: -0.31 SH3GLB1SH3-domain GRB2-like endophilin B1 (ENSG00000097033), score: 0.33 SLAIN2SLAIN motif family, member 2 (ENSG00000109171), score: 0.29 SLC16A1solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (ENSG00000155380), score: 0.33 SLC20A2solute carrier family 20 (phosphate transporter), member 2 (ENSG00000168575), score: 0.35 SLC39A6solute carrier family 39 (zinc transporter), member 6 (ENSG00000141424), score: -0.3 SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (ENSG00000102038), score: -0.35 SMPXsmall muscle protein, X-linked (ENSG00000091482), score: 0.32 SMYD1SET and MYND domain containing 1 (ENSG00000115593), score: 0.37 SMYD2SET and MYND domain containing 2 (ENSG00000143499), score: 0.27 SORBS1sorbin and SH3 domain containing 1 (ENSG00000095637), score: 0.3 SQLEsqualene epoxidase (ENSG00000104549), score: -0.3 SSH2slingshot homolog 2 (Drosophila) (ENSG00000141298), score: 0.29 SSPNsarcospan (Kras oncogene-associated gene) (ENSG00000123096), score: 0.42 STAMBPSTAM binding protein (ENSG00000124356), score: -0.29 STK36serine/threonine kinase 36 (ENSG00000163482), score: -0.3 STRN3striatin, calmodulin binding protein 3 (ENSG00000196792), score: 0.37 SYDE2synapse defective 1, Rho GTPase, homolog 2 (C. elegans) (ENSG00000097096), score: 0.28 SYNPO2synaptopodin 2 (ENSG00000172403), score: 0.31 TACC2transforming, acidic coiled-coil containing protein 2 (ENSG00000138162), score: 0.29 TAF1ATATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa (ENSG00000143498), score: 0.36 TBX20T-box 20 (ENSG00000164532), score: 0.33 TBX5T-box 5 (ENSG00000089225), score: 0.32 TCP11L1t-complex 11 (mouse)-like 1 (ENSG00000176148), score: -0.35 TCP11L2t-complex 11 (mouse)-like 2 (ENSG00000166046), score: 0.41 TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor) (ENSG00000187079), score: 0.42 TECtec protein tyrosine kinase (ENSG00000135605), score: 0.29 TIMM17Atranslocase of inner mitochondrial membrane 17 homolog A (yeast) (ENSG00000134375), score: 0.39 TMCC3transmembrane and coiled-coil domain family 3 (ENSG00000057704), score: 0.29 TMEM14Atransmembrane protein 14A (ENSG00000096092), score: -0.33 TMEM182transmembrane protein 182 (ENSG00000170417), score: 0.37 TMEM201transmembrane protein 201 (ENSG00000188807), score: 0.31 TMEM38Atransmembrane protein 38A (ENSG00000072954), score: 0.41 TMOD1tropomodulin 1 (ENSG00000136842), score: 0.32 TMPRSS13transmembrane protease, serine 13 (ENSG00000137747), score: 0.28 TMTC1transmembrane and tetratricopeptide repeat containing 1 (ENSG00000133687), score: 0.35 TMX1thioredoxin-related transmembrane protein 1 (ENSG00000139921), score: 0.27 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (ENSG00000145779), score: 0.33 TNNC1troponin C type 1 (slow) (ENSG00000114854), score: 0.3 TPM1tropomyosin 1 (alpha) (ENSG00000140416), score: 0.36 TRIM35tripartite motif-containing 35 (ENSG00000104228), score: 0.27 TRIM55tripartite motif-containing 55 (ENSG00000147573), score: 0.3 TRIM63tripartite motif-containing 63 (ENSG00000158022), score: 0.3 TSTD2thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 (ENSG00000136925), score: 0.33 TWSG1twisted gastrulation homolog 1 (Drosophila) (ENSG00000128791), score: 0.27 TXLNBtaxilin beta (ENSG00000164440), score: 0.47 TXNDC9thioredoxin domain containing 9 (ENSG00000115514), score: 0.28 TYW3tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) (ENSG00000162623), score: -0.31 UBR2ubiquitin protein ligase E3 component n-recognin 2 (ENSG00000024048), score: 0.42 UBXN2AUBX domain protein 2A (ENSG00000173960), score: 0.3 UCP3uncoupling protein 3 (mitochondrial, proton carrier) (ENSG00000175564), score: 0.51 UQCR11ubiquinol-cytochrome c reductase, complex III subunit XI (ENSG00000127540), score: 0.32 UQCRC1ubiquinol-cytochrome c reductase core protein I (ENSG00000010256), score: 0.35 UQCRC2ubiquinol-cytochrome c reductase core protein II (ENSG00000140740), score: 0.29 USP28ubiquitin specific peptidase 28 (ENSG00000048028), score: 0.38 USP47ubiquitin specific peptidase 47 (ENSG00000170242), score: 0.31 VLDLRvery low density lipoprotein receptor (ENSG00000147852), score: 0.32 VPS26Avacuolar protein sorting 26 homolog A (S. pombe) (ENSG00000122958), score: 0.28 WDR89WD repeat domain 89 (ENSG00000140006), score: 0.4 WNK1WNK lysine deficient protein kinase 1 (ENSG00000060237), score: 0.29 WNT5Awingless-type MMTV integration site family, member 5A (ENSG00000114251), score: 0.29 ZAKsterile alpha motif and leucine zipper containing kinase AZK (ENSG00000091436), score: 0.31 ZC3H7Azinc finger CCCH-type containing 7A (ENSG00000122299), score: 0.5 ZNF618zinc finger protein 618 (ENSG00000157657), score: -0.3

Non-Entrez genes

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Id species tissue sex individual
mmu_ht_f_ca1 mmu ht f _
mmu_ht_m1_ca1 mmu ht m 1
mmu_ht_m2_ca1 mmu ht m 2

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