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Expression data for module #571

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

heart morphogenesis

The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

muscle system process

A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

cardiac ventricle morphogenesis

The process by which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

cardiac ventricle development

The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

muscle contraction

A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis.

generation of precursor metabolites and energy

The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.

oxidation reduction

The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons.

respiratory electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

oxidative phosphorylation

The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

phosphorus metabolic process

The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).

phosphate metabolic process

The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

heart development

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

striated muscle tissue development

The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells.

energy derivation by oxidation of organic compounds

The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

actin filament-based process

Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

actin-myosin filament sliding

The sliding movement of actin thin filaments and myosin thick filaments past each other.

ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

mitochondrial ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

cellular respiration

The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).

intracellular transport

The directed movement of substances within a cell.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

muscle tissue development

The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.

muscle structure development

The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.

actin-mediated cell contraction

The actin filament-based process by which cytoplasmic actin filaments slide past one another resulting in contraction of all or part of the cell body.

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

intracellular transport

The directed movement of substances within a cell.

electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

actin-myosin filament sliding

The sliding movement of actin thin filaments and myosin thick filaments past each other.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

muscle organ development

The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.

ATP synthesis coupled electron transport

The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.

muscle filament sliding

The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.

cardiac chamber morphogenesis

The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.

cardiac ventricle morphogenesis

The process by which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

heart morphogenesis

The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

muscle tissue development

The progression of muscle tissue over time, from its initial formation to its mature state. Muscle tissue is a contractile tissue made up of actin and myosin fibers.

actin filament-based movement

Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.

respiratory electron transport chain

A process whereby a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

oxidative phosphorylation

The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.

cardiac muscle tissue development

The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

mitochondrial envelope

The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.

mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

striated muscle thin filament

Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.

adherens junction

A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.

actin cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.

organelle inner membrane

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.

myofibril

The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

cell junction

A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

organelle membrane

The lipid bilayer surrounding an organelle.

pseudopodium

A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.

I band

A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

organelle envelope

A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.

envelope

A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

mitochondrial membrane part

Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

anchoring junction

A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.

respiratory chain

The protein complexes that form the electron transport system (the respiratory chain), associated with a cell membrane, usually the plasma membrane (in prokaryotes) or the inner mitochondrial membrane (on eukaryotes). The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

organelle envelope

A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

organelle envelope

A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.

organelle inner membrane

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

organelle inner membrane

The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.

mitochondrial inner membrane

The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.

mitochondrial membrane part

Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

mitochondrial envelope

The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

mitochondrial membrane part

Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

striated muscle thin filament

Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.

striated muscle thin filament

Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.

I band

A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.

Z disc

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

contractile fiber

Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

mitochondrial membrane

Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

contractile fiber part

Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

mitochondrial respiratory chain

The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient.

sarcomere

The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

striated muscle thin filament

Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils.

Help | Hide | Top The GO tree — Molecular Function

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protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

actin binding

Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.

structural molecule activity

The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

cytoskeletal protein binding

Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

structural constituent of muscle

The action of a molecule that contributes to the structural integrity of a muscle fiber.

all

NA

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04260 1.212e-05 1.508 11
25 Cardiac muscle contraction
05414 4.282e-05 2.051 12
34 Dilated cardiomyopathy
05410 1.509e-03 2.051 10
34 Hypertrophic cardiomyopathy (HCM)
05012 7.271e-03 1.628 8
27 Parkinson's disease
00190 1.411e-02 1.809 8
30 Oxidative phosphorylation
05412 1.699e-02 1.87 8
31 Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Help | Hide | Top miRNA test for over-representation

No enriched terms

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABLIM1actin binding LIM protein 1 (ENSG00000099204), score: 0.59 ABRAactin-binding Rho activating protein (ENSG00000174429), score: 0.56 ACTN2actinin, alpha 2 (ENSG00000077522), score: 0.66 ADALadenosine deaminase-like (ENSG00000168803), score: 0.49 ADAMTSL5ADAMTS-like 5 (ENSG00000185761), score: 0.56 ADCY5adenylate cyclase 5 (ENSG00000173175), score: 0.56 ADNPactivity-dependent neuroprotector homeobox (ENSG00000101126), score: -0.51 ADSSL1adenylosuccinate synthase like 1 (ENSG00000185100), score: 0.58 AFAP1L1actin filament associated protein 1-like 1 (ENSG00000157510), score: 0.58 AFTPHaftiphilin (ENSG00000119844), score: -0.59 AKAP13A kinase (PRKA) anchor protein 13 (ENSG00000170776), score: 0.64 ANAPC16anaphase promoting complex subunit 16 (ENSG00000166295), score: 0.59 ANGPTL2angiopoietin-like 2 (ENSG00000136859), score: 0.51 ANKRD1ankyrin repeat domain 1 (cardiac muscle) (ENSG00000148677), score: 0.88 ANKRD2ankyrin repeat domain 2 (stretch responsive muscle) (ENSG00000165887), score: 0.52 ANO5anoctamin 5 (ENSG00000171714), score: 0.58 ANXA1annexin A1 (ENSG00000135046), score: 0.48 APOBEC2apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 (ENSG00000124701), score: 0.72 AQP11aquaporin 11 (ENSG00000178301), score: -0.52 ARHGAP10Rho GTPase activating protein 10 (ENSG00000071205), score: 0.58 ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 (ENSG00000129675), score: 0.56 ARIH2ariadne homolog 2 (Drosophila) (ENSG00000177479), score: 0.48 ARL6IP1ADP-ribosylation factor-like 6 interacting protein 1 (ENSG00000170540), score: -0.7 ARL6IP5ADP-ribosylation-like factor 6 interacting protein 5 (ENSG00000144746), score: 0.5 ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1 (ENSG00000104763), score: 0.56 ASB11ankyrin repeat and SOCS box-containing 11 (ENSG00000165192), score: 0.78 ASB14ankyrin repeat and SOCS box-containing 14 (ENSG00000239388), score: 0.5 ASB15ankyrin repeat and SOCS box-containing 15 (ENSG00000146809), score: 0.67 ASB2ankyrin repeat and SOCS box-containing 2 (ENSG00000100628), score: 0.64 ASPNasporin (ENSG00000106819), score: 0.53 ATP13A1ATPase type 13A1 (ENSG00000105726), score: -0.54 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ENSG00000174437), score: 0.5 ATPAF1ATP synthase mitochondrial F1 complex assembly factor 1 (ENSG00000123472), score: 0.6 ATPIF1ATPase inhibitory factor 1 (ENSG00000130770), score: 0.58 B3GALTLbeta 1,3-galactosyltransferase-like (ENSG00000187676), score: 0.56 BCL2L13BCL2-like 13 (apoptosis facilitator) (ENSG00000099968), score: 0.58 BRI3BPBRI3 binding protein (ENSG00000184992), score: -0.74 C10orf76chromosome 10 open reading frame 76 (ENSG00000120029), score: 0.64 C14orf159chromosome 14 open reading frame 159 (ENSG00000133943), score: 0.51 C15orf41chromosome 15 open reading frame 41 (ENSG00000186073), score: 0.71 C18orf55chromosome 18 open reading frame 55 (ENSG00000075336), score: 0.61 C19orf28chromosome 19 open reading frame 28 (ENSG00000161091), score: -0.49 C1orf151chromosome 1 open reading frame 151 (ENSG00000173436), score: 0.73 C1QTNF1C1q and tumor necrosis factor related protein 1 (ENSG00000173918), score: 0.5 C6orf142chromosome 6 open reading frame 142 (ENSG00000146147), score: 0.7 C6orf192chromosome 6 open reading frame 192 (ENSG00000146409), score: -0.49 CABLES1Cdk5 and Abl enzyme substrate 1 (ENSG00000134508), score: -0.56 CACNA1Ccalcium channel, voltage-dependent, L type, alpha 1C subunit (ENSG00000151067), score: 0.5 CAMK2Dcalcium/calmodulin-dependent protein kinase II delta (ENSG00000145349), score: 0.48 CAND2cullin-associated and neddylation-dissociated 2 (putative) (ENSG00000144712), score: 0.48 CAPZA2capping protein (actin filament) muscle Z-line, alpha 2 (ENSG00000198898), score: 0.61 CASTcalpastatin (ENSG00000153113), score: 0.62 CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b (ENSG00000114423), score: 0.68 CCDC76coiled-coil domain containing 76 (ENSG00000122435), score: 0.47 CCDC80coiled-coil domain containing 80 (ENSG00000091986), score: 0.6 CCND2cyclin D2 (ENSG00000118971), score: 0.58 CD274CD274 molecule (ENSG00000120217), score: 0.71 CD34CD34 molecule (ENSG00000174059), score: 0.52 CDC42EP3CDC42 effector protein (Rho GTPase binding) 3 (ENSG00000163171), score: 0.53 CDH13cadherin 13, H-cadherin (heart) (ENSG00000140945), score: 0.56 CDH2cadherin 2, type 1, N-cadherin (neuronal) (ENSG00000170558), score: 0.63 CDK13cyclin-dependent kinase 13 (ENSG00000065883), score: -0.51 CDS1CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 (ENSG00000163624), score: -0.52 CFLARCASP8 and FADD-like apoptosis regulator (ENSG00000003402), score: 0.63 CHN2chimerin (chimaerin) 2 (ENSG00000106069), score: -0.49 CHST9carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 (ENSG00000154080), score: 0.48 CLIC5chloride intracellular channel 5 (ENSG00000112782), score: 0.65 CMYA5cardiomyopathy associated 5 (ENSG00000164309), score: 0.76 CNIH4cornichon homolog 4 (Drosophila) (ENSG00000143771), score: 0.5 CNNM2cyclin M2 (ENSG00000148842), score: -0.59 COL15A1collagen, type XV, alpha 1 (ENSG00000204291), score: 0.59 COL6A3collagen, type VI, alpha 3 (ENSG00000163359), score: 0.57 COMMD10COMM domain containing 10 (ENSG00000145781), score: 0.53 COQ9coenzyme Q9 homolog (S. cerevisiae) (ENSG00000088682), score: 0.48 COX10COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) (ENSG00000006695), score: 0.48 COX4I1cytochrome c oxidase subunit IV isoform 1 (ENSG00000131143), score: 0.57 CPEB4cytoplasmic polyadenylation element binding protein 4 (ENSG00000113742), score: 0.48 CRYABcrystallin, alpha B (ENSG00000109846), score: 0.5 CRYMcrystallin, mu (ENSG00000103316), score: -0.48 CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein) (ENSG00000129170), score: 0.79 CUL4Acullin 4A (ENSG00000139842), score: 0.48 CYBASC3cytochrome b, ascorbate dependent 3 (ENSG00000162144), score: -0.48 DCNdecorin (ENSG00000011465), score: 0.48 DCUN1D2DCN1, defective in cullin neddylation 1, domain containing 2 (S. cerevisiae) (ENSG00000150401), score: 0.59 DDA1DET1 and DDB1 associated 1 (ENSG00000130311), score: 0.5 DDR2discoidin domain receptor tyrosine kinase 2 (ENSG00000162733), score: 0.48 DDX1DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 (ENSG00000079785), score: 0.68 DECR12,4-dienoyl CoA reductase 1, mitochondrial (ENSG00000104325), score: 0.51 DHX35DEAH (Asp-Glu-Ala-His) box polypeptide 35 (ENSG00000101452), score: 0.48 DLDdihydrolipoamide dehydrogenase (ENSG00000091140), score: 0.52 DNAJC12DnaJ (Hsp40) homolog, subfamily C, member 12 (ENSG00000108176), score: -0.57 DOLPP1dolichyl pyrophosphate phosphatase 1 (ENSG00000167130), score: -0.51 DPTdermatopontin (ENSG00000143196), score: 0.58 DPY19L3dpy-19-like 3 (C. elegans) (ENSG00000178904), score: -0.54 DSPdesmoplakin (ENSG00000096696), score: 0.56 DTWD2DTW domain containing 2 (ENSG00000169570), score: 0.54 DUS4Ldihydrouridine synthase 4-like (S. cerevisiae) (ENSG00000105865), score: 0.55 DUSP13dual specificity phosphatase 13 (ENSG00000079393), score: 0.52 DUSP27dual specificity phosphatase 27 (putative) (ENSG00000198842), score: 0.79 DYRK1Adual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (ENSG00000157540), score: 0.47 EDNRAendothelin receptor type A (ENSG00000151617), score: 0.55 EEF2Keukaryotic elongation factor-2 kinase (ENSG00000103319), score: 0.66 EIF3Aeukaryotic translation initiation factor 3, subunit A (ENSG00000107581), score: 0.64 EIF5Beukaryotic translation initiation factor 5B (ENSG00000158417), score: 0.56 EMILIN2elastin microfibril interfacer 2 (ENSG00000132205), score: 0.57 EMP1epithelial membrane protein 1 (ENSG00000134531), score: 0.5 ENTPD1ectonucleoside triphosphate diphosphohydrolase 1 (ENSG00000138185), score: 0.55 ERGv-ets erythroblastosis virus E26 oncogene homolog (avian) (ENSG00000157554), score: 0.51 ESYT2extended synaptotagmin-like protein 2 (ENSG00000117868), score: 0.54 ETV5ets variant 5 (ENSG00000244405), score: -0.55 F8coagulation factor VIII, procoagulant component (ENSG00000185010), score: 0.49 FAAHfatty acid amide hydrolase (ENSG00000117480), score: -0.5 FAM116Bfamily with sequence similarity 116, member B (ENSG00000205593), score: -0.49 FAM129Afamily with sequence similarity 129, member A (ENSG00000135842), score: 0.72 FAM198Bfamily with sequence similarity 198, member B (ENSG00000164125), score: 0.55 FAM36Afamily with sequence similarity 36, member A (ENSG00000203667), score: 0.52 FASNfatty acid synthase (ENSG00000169710), score: -0.54 FASTKD2FAST kinase domains 2 (ENSG00000118246), score: 0.55 FBLIM1filamin binding LIM protein 1 (ENSG00000162458), score: 0.55 FBN1fibrillin 1 (ENSG00000166147), score: 0.51 FBXL7F-box and leucine-rich repeat protein 7 (ENSG00000183580), score: 0.62 FBXO30F-box protein 30 (ENSG00000118496), score: 0.47 FBXO32F-box protein 32 (ENSG00000156804), score: 0.71 FBXO33F-box protein 33 (ENSG00000165355), score: -0.54 FBXO40F-box protein 40 (ENSG00000163833), score: 0.8 FBXO9F-box protein 9 (ENSG00000112146), score: -0.5 FBXW4F-box and WD repeat domain containing 4 (ENSG00000107829), score: 0.47 FGF12fibroblast growth factor 12 (ENSG00000114279), score: 0.49 FGF18fibroblast growth factor 18 (ENSG00000156427), score: 0.87 FGFR2fibroblast growth factor receptor 2 (ENSG00000066468), score: -0.61 FHL2four and a half LIM domains 2 (ENSG00000115641), score: 0.59 FHOD3formin homology 2 domain containing 3 (ENSG00000134775), score: 0.66 FICDFIC domain containing (ENSG00000198855), score: -0.67 FILIP1filamin A interacting protein 1 (ENSG00000118407), score: 0.7 FITM2fat storage-inducing transmembrane protein 2 (ENSG00000197296), score: 0.65 FKBP9FK506 binding protein 9, 63 kDa (ENSG00000122642), score: 0.46 FSD2fibronectin type III and SPRY domain containing 2 (ENSG00000186628), score: 0.72 FXR1fragile X mental retardation, autosomal homolog 1 (ENSG00000114416), score: 0.54 FYCO1FYVE and coiled-coil domain containing 1 (ENSG00000163820), score: 0.56 FYTTD1forty-two-three domain containing 1 (ENSG00000122068), score: 0.51 GAB3GRB2-associated binding protein 3 (ENSG00000160219), score: 0.56 GATA4GATA binding protein 4 (ENSG00000136574), score: 0.57 GATA6GATA binding protein 6 (ENSG00000141448), score: 0.47 GCOM1GRINL1A complex locus (ENSG00000137878), score: 0.86 GEMGTP binding protein overexpressed in skeletal muscle (ENSG00000164949), score: 0.58 GFM2G elongation factor, mitochondrial 2 (ENSG00000164347), score: 0.49 GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) (ENSG00000137563), score: -0.71 GHITMgrowth hormone inducible transmembrane protein (ENSG00000165678), score: 0.65 GJA3gap junction protein, alpha 3, 46kDa (ENSG00000121743), score: 0.56 GJB1gap junction protein, beta 1, 32kDa (ENSG00000169562), score: -0.51 GLDCglycine dehydrogenase (decarboxylating) (ENSG00000178445), score: -0.49 GLT8D2glycosyltransferase 8 domain containing 2 (ENSG00000120820), score: 0.49 GMPRguanosine monophosphate reductase (ENSG00000137198), score: 0.53 GRIP2glutamate receptor interacting protein 2 (ENSG00000144596), score: 0.61 GRK5G protein-coupled receptor kinase 5 (ENSG00000198873), score: 0.59 GTPBP8GTP-binding protein 8 (putative) (ENSG00000163607), score: 0.47 HAT1histone acetyltransferase 1 (ENSG00000128708), score: 0.52 HEY2hairy/enhancer-of-split related with YRPW motif 2 (ENSG00000135547), score: 0.66 HGShepatocyte growth factor-regulated tyrosine kinase substrate (ENSG00000185359), score: -0.48 HHATLhedgehog acyltransferase-like (ENSG00000010282), score: 0.56 HIF1ANhypoxia inducible factor 1, alpha subunit inhibitor (ENSG00000166135), score: 0.58 HMCN1hemicentin 1 (ENSG00000143341), score: 0.47 HMGCR3-hydroxy-3-methylglutaryl-CoA reductase (ENSG00000113161), score: -0.6 HRH2histamine receptor H2 (ENSG00000113749), score: 0.46 IL17Binterleukin 17B (ENSG00000127743), score: 0.5 IP6K1inositol hexakisphosphate kinase 1 (ENSG00000176095), score: -0.58 ITGB1BP1integrin beta 1 binding protein 1 (ENSG00000119185), score: 0.51 ITPRIPinositol 1,4,5-triphosphate receptor interacting protein (ENSG00000148841), score: 0.49 KBTBD10kelch repeat and BTB (POZ) domain containing 10 (ENSG00000239474), score: 0.8 KBTBD5kelch repeat and BTB (POZ) domain containing 5 (ENSG00000157119), score: 0.89 KCNJ8potassium inwardly-rectifying channel, subfamily J, member 8 (ENSG00000121361), score: 0.56 KIAA0232KIAA0232 (ENSG00000170871), score: 0.63 KIAA1598KIAA1598 (ENSG00000187164), score: -0.58 KIF13Akinesin family member 13A (ENSG00000137177), score: 0.66 KIF5Bkinesin family member 5B (ENSG00000170759), score: 0.51 KLHDC8Bkelch domain containing 8B (ENSG00000185909), score: 0.58 KLHL24kelch-like 24 (Drosophila) (ENSG00000114796), score: 0.67 KLHL25kelch-like 25 (Drosophila) (ENSG00000183655), score: -0.6 KLHL31kelch-like 31 (Drosophila) (ENSG00000124743), score: 0.77 KLHL38kelch-like 38 (Drosophila) (ENSG00000175946), score: 0.94 KLHL7kelch-like 7 (Drosophila) (ENSG00000122550), score: 0.68 LAMA4laminin, alpha 4 (ENSG00000112769), score: 0.62 LAPTM4Blysosomal protein transmembrane 4 beta (ENSG00000104341), score: 0.5 LBHlimb bud and heart development homolog (mouse) (ENSG00000213626), score: 0.57 LDB3LIM domain binding 3 (ENSG00000122367), score: 0.75 LGALS3lectin, galactoside-binding, soluble, 3 (ENSG00000131981), score: 0.47 LIMS2LIM and senescent cell antigen-like domains 2 (ENSG00000072163), score: 0.58 LMOD2leiomodin 2 (cardiac) (ENSG00000170807), score: 0.8 LOC100291405similar to protein tyrosine phosphatase-like A domain containing 1 (ENSG00000074696), score: -0.58 LOC100291671similar to SH3-binding domain and glutamic acid-rich protein (ENSG00000185437), score: 0.68 LPAR3lysophosphatidic acid receptor 3 (ENSG00000171517), score: 0.64 LPIN2lipin 2 (ENSG00000101577), score: -0.51 LRRC10leucine rich repeat containing 10 (ENSG00000198812), score: 0.69 LRRC14Bleucine rich repeat containing 14B (ENSG00000185028), score: 0.8 LRRC2leucine rich repeat containing 2 (ENSG00000163827), score: 0.7 LRRC20leucine rich repeat containing 20 (ENSG00000172731), score: 0.51 LRRC39leucine rich repeat containing 39 (ENSG00000122477), score: 0.83 MALLmal, T-cell differentiation protein-like (ENSG00000144063), score: 0.48 MAP7microtubule-associated protein 7 (ENSG00000135525), score: -0.56 MAPKAP1mitogen-activated protein kinase associated protein 1 (ENSG00000119487), score: 0.5 MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2 (ENSG00000162889), score: 0.68 MAPKAPK3mitogen-activated protein kinase-activated protein kinase 3 (ENSG00000114738), score: 0.86 ME2malic enzyme 2, NAD(+)-dependent, mitochondrial (ENSG00000082212), score: 0.52 MEGF9multiple EGF-like-domains 9 (ENSG00000106780), score: -0.54 MEOX2mesenchyme homeobox 2 (ENSG00000106511), score: 0.75 METRNLmeteorin, glial cell differentiation regulator-like (ENSG00000176845), score: 0.59 METTL11Bmethyltransferase like 11B (ENSG00000203740), score: 1 MFN2mitofusin 2 (ENSG00000116688), score: 0.73 MFSD2Amajor facilitator superfamily domain containing 2A (ENSG00000168389), score: -0.55 MLPHmelanophilin (ENSG00000115648), score: 0.5 MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (ENSG00000087245), score: 0.48 MMRN2multimerin 2 (ENSG00000173269), score: 0.5 MPDZmultiple PDZ domain protein (ENSG00000107186), score: 0.47 MRPL15mitochondrial ribosomal protein L15 (ENSG00000137547), score: 0.55 MRPL16mitochondrial ribosomal protein L16 (ENSG00000166902), score: 0.47 MRPL21mitochondrial ribosomal protein L21 (ENSG00000197345), score: 0.55 MRPL22mitochondrial ribosomal protein L22 (ENSG00000082515), score: 0.57 MRPL51mitochondrial ribosomal protein L51 (ENSG00000111639), score: 0.53 MRPS23mitochondrial ribosomal protein S23 (ENSG00000181610), score: 0.58 MRPS9mitochondrial ribosomal protein S9 (ENSG00000135972), score: 0.72 MTERFD3MTERF domain containing 3 (ENSG00000120832), score: 0.47 MTIF3mitochondrial translational initiation factor 3 (ENSG00000122033), score: 0.51 MURCmuscle-related coiled-coil protein (ENSG00000170681), score: 0.52 MYBPC3myosin binding protein C, cardiac (ENSG00000134571), score: 0.73 MYCT1myc target 1 (ENSG00000120279), score: 0.52 MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow (ENSG00000160808), score: 0.73 MYLK3myosin light chain kinase 3 (ENSG00000140795), score: 0.62 MYLK4myosin light chain kinase family, member 4 (ENSG00000145949), score: 0.74 MYOCmyocilin, trabecular meshwork inducible glucocorticoid response (ENSG00000034971), score: 0.64 MYOCDmyocardin (ENSG00000141052), score: 0.69 MYOM2myomesin (M-protein) 2, 165kDa (ENSG00000036448), score: 0.66 MYOM3myomesin family, member 3 (ENSG00000142661), score: 0.89 MYOZ1myozenin 1 (ENSG00000177791), score: 0.63 MYOZ2myozenin 2 (ENSG00000172399), score: 0.81 MYPNmyopalladin (ENSG00000138347), score: 0.82 ND3NADH dehydrogenase, subunit 3 (complex I) (ENSG00000198840), score: 0.47 ND4NADH dehydrogenase, subunit 4 (complex I) (ENSG00000198886), score: 0.51 NDUFA12NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 (ENSG00000184752), score: 0.72 NDUFA8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa (ENSG00000119421), score: 0.53 NDUFS3NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) (ENSG00000213619), score: 0.58 NEBLnebulette (ENSG00000078114), score: 0.54 NEK9NIMA (never in mitosis gene a)- related kinase 9 (ENSG00000119638), score: 0.61 NFU1NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae) (ENSG00000169599), score: 0.59 NGEFneuronal guanine nucleotide exchange factor (ENSG00000066248), score: -0.52 NHLRC2NHL repeat containing 2 (ENSG00000196865), score: 0.72 NINninein (GSK3B interacting protein) (ENSG00000100503), score: 0.53 NRAPnebulin-related anchoring protein (ENSG00000197893), score: 0.7 NT5C1A5'-nucleotidase, cytosolic IA (ENSG00000116981), score: 0.55 NUBPLnucleotide binding protein-like (ENSG00000151413), score: 0.49 P2RX1purinergic receptor P2X, ligand-gated ion channel, 1 (ENSG00000108405), score: 0.55 PAIP1poly(A) binding protein interacting protein 1 (ENSG00000172239), score: 0.49 PALMDpalmdelphin (ENSG00000099260), score: 0.62 PAMpeptidylglycine alpha-amidating monooxygenase (ENSG00000145730), score: 0.52 PARVBparvin, beta (ENSG00000188677), score: 0.51 PBX3pre-B-cell leukemia homeobox 3 (ENSG00000167081), score: 0.67 PDAP1PDGFA associated protein 1 (ENSG00000106244), score: 0.53 PDCD5programmed cell death 5 (ENSG00000105185), score: 0.49 PDE3Aphosphodiesterase 3A, cGMP-inhibited (ENSG00000172572), score: 0.7 PDE7Aphosphodiesterase 7A (ENSG00000205268), score: 0.6 PDGFRLplatelet-derived growth factor receptor-like (ENSG00000104213), score: 0.51 PDHBpyruvate dehydrogenase (lipoamide) beta (ENSG00000168291), score: 0.53 PDLIM5PDZ and LIM domain 5 (ENSG00000163110), score: 0.63 PDZRN3PDZ domain containing ring finger 3 (ENSG00000121440), score: 0.67 PFKFB46-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (ENSG00000114268), score: -0.49 PHLPP1PH domain and leucine rich repeat protein phosphatase 1 (ENSG00000081913), score: -0.5 PIGNphosphatidylinositol glycan anchor biosynthesis, class N (ENSG00000197563), score: 0.49 PLAAphospholipase A2-activating protein (ENSG00000137055), score: 0.46 PLCL1phospholipase C-like 1 (ENSG00000115896), score: 0.68 PLCXD2phosphatidylinositol-specific phospholipase C, X domain containing 2 (ENSG00000144824), score: 0.54 PLEKHA2pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 (ENSG00000169499), score: 0.56 PLEKHF1pleckstrin homology domain containing, family F (with FYVE domain) member 1 (ENSG00000166289), score: 0.47 PLNphospholamban (ENSG00000198523), score: 0.74 POF1Bpremature ovarian failure, 1B (ENSG00000124429), score: 0.69 POSTNperiostin, osteoblast specific factor (ENSG00000133110), score: 0.8 PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha (ENSG00000109819), score: 0.47 PPP1R13Bprotein phosphatase 1, regulatory (inhibitor) subunit 13B (ENSG00000088808), score: 0.5 PPP1R14Cprotein phosphatase 1, regulatory (inhibitor) subunit 14C (ENSG00000198729), score: 0.68 PPP1R1Cprotein phosphatase 1, regulatory (inhibitor) subunit 1C (ENSG00000150722), score: 0.83 PPP1R3Aprotein phosphatase 1, regulatory (inhibitor) subunit 3A (ENSG00000154415), score: 0.93 PPTC7PTC7 protein phosphatase homolog (S. cerevisiae) (ENSG00000196850), score: 0.59 PRKCHprotein kinase C, eta (ENSG00000027075), score: 0.48 PSMA4proteasome (prosome, macropain) subunit, alpha type, 4 (ENSG00000041357), score: 0.48 PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 (ENSG00000163636), score: 0.48 PTDSS1phosphatidylserine synthase 1 (ENSG00000156471), score: 0.82 PTGFRNprostaglandin F2 receptor negative regulator (ENSG00000134247), score: 0.59 PTRFpolymerase I and transcript release factor (ENSG00000177469), score: 0.56 RAB11FIP1RAB11 family interacting protein 1 (class I) (ENSG00000156675), score: 0.49 RAB9BRAB9B, member RAS oncogene family (ENSG00000123570), score: 0.5 RBM20RNA binding motif protein 20 (ENSG00000203867), score: 0.72 RBM24RNA binding motif protein 24 (ENSG00000112183), score: 0.73 RBPMS2RNA binding protein with multiple splicing 2 (ENSG00000166831), score: 0.56 REXO2REX2, RNA exonuclease 2 homolog (S. cerevisiae) (ENSG00000076043), score: 0.63 RILPL1Rab interacting lysosomal protein-like 1 (ENSG00000188026), score: 0.52 RNMTL1RNA methyltransferase like 1 (ENSG00000171861), score: 0.51 ROCK1Rho-associated, coiled-coil containing protein kinase 1 (ENSG00000067900), score: 0.51 RPL3Lribosomal protein L3-like (ENSG00000140986), score: 0.67 RRADRas-related associated with diabetes (ENSG00000166592), score: 0.54 RSAD2radical S-adenosyl methionine domain containing 2 (ENSG00000134321), score: 0.56 RYR2ryanodine receptor 2 (cardiac) (ENSG00000198626), score: 0.69 SALL1sal-like 1 (Drosophila) (ENSG00000103449), score: -0.53 SEMA3Csema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C (ENSG00000075223), score: 0.58 SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) (ENSG00000102683), score: 0.76 SGPP1sphingosine-1-phosphate phosphatase 1 (ENSG00000126821), score: -0.55 SH3RF2SH3 domain containing ring finger 2 (ENSG00000156463), score: 0.49 SHROOM2shroom family member 2 (ENSG00000146950), score: -0.53 SIK3SIK family kinase 3 (ENSG00000160584), score: -0.52 SIPA1L1signal-induced proliferation-associated 1 like 1 (ENSG00000197555), score: -0.61 SIRT5sirtuin 5 (ENSG00000124523), score: 0.6 SLC16A1solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (ENSG00000155380), score: 0.53 SLC25A17solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 (ENSG00000100372), score: -0.58 SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 (ENSG00000075415), score: 0.53 SLC25A30solute carrier family 25, member 30 (ENSG00000174032), score: 0.65 SLC25A33solute carrier family 25, member 33 (ENSG00000171612), score: -0.52 SLC26A9solute carrier family 26, member 9 (ENSG00000174502), score: 0.92 SLC2A8solute carrier family 2 (facilitated glucose transporter), member 8 (ENSG00000136856), score: -0.49 SLC35B4solute carrier family 35, member B4 (ENSG00000205060), score: -0.55 SLC41A1solute carrier family 41, member 1 (ENSG00000133065), score: 0.79 SLC8A1solute carrier family 8 (sodium/calcium exchanger), member 1 (ENSG00000183023), score: 0.7 SMPXsmall muscle protein, X-linked (ENSG00000091482), score: 0.72 SMYD1SET and MYND domain containing 1 (ENSG00000115593), score: 0.67 SMYD2SET and MYND domain containing 2 (ENSG00000143499), score: 0.66 SNAPC4small nuclear RNA activating complex, polypeptide 4, 190kDa (ENSG00000165684), score: -0.52 SNX10sorting nexin 10 (ENSG00000086300), score: -0.53 SNX3sorting nexin 3 (ENSG00000112335), score: 0.6 SORBS1sorbin and SH3 domain containing 1 (ENSG00000095637), score: 0.65 SPIRE2spire homolog 2 (Drosophila) (ENSG00000204991), score: -0.49 SQLEsqualene epoxidase (ENSG00000104549), score: -0.53 SSBP1single-stranded DNA binding protein 1 (ENSG00000106028), score: 0.56 STX11syntaxin 11 (ENSG00000135604), score: 0.59 STX17syntaxin 17 (ENSG00000136874), score: 0.47 SWAP70SWAP switching B-cell complex 70kDa subunit (ENSG00000133789), score: 0.46 SYF2SYF2 homolog, RNA splicing factor (S. cerevisiae) (ENSG00000117614), score: 0.53 SYNMsynemin, intermediate filament protein (ENSG00000182253), score: 0.75 SYNPO2synaptopodin 2 (ENSG00000172403), score: 0.68 TACC2transforming, acidic coiled-coil containing protein 2 (ENSG00000138162), score: 0.62 TAF15TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa (ENSG00000172660), score: 0.54 TARSL2threonyl-tRNA synthetase-like 2 (ENSG00000185418), score: 0.47 TBX20T-box 20 (ENSG00000164532), score: 0.76 TBX5T-box 5 (ENSG00000089225), score: 0.62 TEAD1TEA domain family member 1 (SV40 transcriptional enhancer factor) (ENSG00000187079), score: 0.62 TECRLtrans-2,3-enoyl-CoA reductase-like (ENSG00000205678), score: 0.79 TIMM44translocase of inner mitochondrial membrane 44 homolog (yeast) (ENSG00000104980), score: 0.5 TMEM182transmembrane protein 182 (ENSG00000170417), score: 0.9 TMOD1tropomodulin 1 (ENSG00000136842), score: 0.53 TMX4thioredoxin-related transmembrane protein 4 (ENSG00000125827), score: 0.51 TNNC1troponin C type 1 (slow) (ENSG00000114854), score: 0.75 TNNT2troponin T type 2 (cardiac) (ENSG00000118194), score: 0.66 TOP2Btopoisomerase (DNA) II beta 180kDa (ENSG00000077097), score: 0.53 TOR2Atorsin family 2, member A (ENSG00000160404), score: -0.48 TPM1tropomyosin 1 (alpha) (ENSG00000140416), score: 0.82 TPST1tyrosylprotein sulfotransferase 1 (ENSG00000169902), score: -0.5 TRAF2TNF receptor-associated factor 2 (ENSG00000127191), score: -0.69 TRIM55tripartite motif-containing 55 (ENSG00000147573), score: 0.58 TRIM63tripartite motif-containing 63 (ENSG00000158022), score: 0.7 TSEN54tRNA splicing endonuclease 54 homolog (S. cerevisiae) (ENSG00000182173), score: -0.53 TSTD2thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 (ENSG00000136925), score: 0.57 TXLNBtaxilin beta (ENSG00000164440), score: 0.7 TYRP1tyrosinase-related protein 1 (ENSG00000107165), score: 0.89 UBE2G2ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) (ENSG00000184787), score: 0.48 UQCRC1ubiquinol-cytochrome c reductase core protein I (ENSG00000010256), score: 0.59 UQCRC2ubiquinol-cytochrome c reductase core protein II (ENSG00000140740), score: 0.61 USP28ubiquitin specific peptidase 28 (ENSG00000048028), score: 0.55 VEZTvezatin, adherens junctions transmembrane protein (ENSG00000028203), score: 0.51 VIPR2vasoactive intestinal peptide receptor 2 (ENSG00000106018), score: 0.59 VITvitrin (ENSG00000205221), score: 0.54 VPS16vacuolar protein sorting 16 homolog (S. cerevisiae) (ENSG00000215305), score: -0.58 VRK2vaccinia related kinase 2 (ENSG00000028116), score: 0.54 WDR91WD repeat domain 91 (ENSG00000105875), score: -0.56 WISP2WNT1 inducible signaling pathway protein 2 (ENSG00000064205), score: 0.53 WTIPWilms tumor 1 interacting protein (ENSG00000142279), score: 0.63 XPO4exportin 4 (ENSG00000132953), score: 0.61 YRDCyrdC domain containing (E. coli) (ENSG00000196449), score: -0.61 ZAKsterile alpha motif and leucine zipper containing kinase AZK (ENSG00000091436), score: 0.8 ZBTB43zinc finger and BTB domain containing 43 (ENSG00000169155), score: 0.71 ZEB1zinc finger E-box binding homeobox 1 (ENSG00000148516), score: 0.65 ZNF276zinc finger protein 276 (ENSG00000158805), score: -0.49 ZNF330zinc finger protein 330 (ENSG00000109445), score: 0.88 ZNF385Bzinc finger protein 385B (ENSG00000144331), score: -0.49 ZNF821zinc finger protein 821 (ENSG00000102984), score: -0.56 ZNRF3zinc and ring finger 3 (ENSG00000183579), score: -0.49

Non-Entrez genes

Unknown, score:

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Id species tissue sex individual
ptr_ht_f_ca1 ptr ht f _
ggo_ht_f_ca1 ggo ht f _
ppy_ht_m_ca1 ppy ht m _
ppa_ht_f_ca1 ppa ht f _
ptr_ht_m_ca1 ptr ht m _

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© 2008-2010 Computational Biology Group, Department of Medical Genetics, University of Lausanne, Switzerland