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system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

organic acid transport

The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of, within or between cells by means of some external agent such as a transporter or pore.

vitamin transport

The directed movement of vitamins into, out of, within or between cells by means of some external agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

carboxylic acid transport

The directed movement of carboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-).

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

all

NA

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

lytic vacuole

A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

sodium channel complex

An ion channel complex through which sodium ions pass.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

enzyme inhibitor activity

Stops, prevents or reduces the activity of an enzyme.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

metalloendopeptidase inhibitor activity

Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.

metalloenzyme regulator activity

Modulates the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal.

endopeptidase regulator activity

Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

enzyme regulator activity

Modulates the activity of an enzyme.

metalloenzyme inhibitor activity

Stops, prevents or reduces the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal.

peptidase regulator activity

Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

all

NA

metalloenzyme inhibitor activity

Stops, prevents or reduces the activity of a metalloenzyme. A metalloenzyme is any enzyme that contains metal.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

metalloendopeptidase inhibitor activity

Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0007588	6.954e-05	1.766	11 AQP3, ATP6V0A4, AVPR1A, CLCN5, CLDN16, DAB2, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G	24	excretion
GO:0006811	7.540e-04	24.43	47 ABCC4, ATP1B4, ATP6V0A4, ATP6V0D2, BDKRB1, BSPRY, CHRNA9, CLCN5, CLDN16, CLIC3, CLIC6, CNNM2, CYSLTR1, EGF, GABRP, HTT, KCND3, KCNJ1, KCNJ16, KCNK5, LPAR3, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SGK1, SLC10A2, SLC13A3, SLC17A5, SLC22A4, SLC26A7, SLC30A6, SLC30A7, SLC34A1, SLC39A9, SLC40A1, SLC5A11, SLC5A12, SLC5A9, TCN2, TMCO3, TRPM6, TRPV4, VPS4B, WNK1, ZDHHC13	332	ion transport
GO:0006812	1.910e-03	16.78	35 ATP1B4, ATP6V0A4, ATP6V0D2, BDKRB1, BSPRY, CHRNA9, CYSLTR1, EGF, KCND3, KCNJ1, KCNJ16, KCNK5, LPAR3, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SGK1, SLC10A2, SLC13A3, SLC22A4, SLC30A6, SLC30A7, SLC34A1, SLC39A9, SLC40A1, SLC5A11, SLC5A12, SLC5A9, TCN2, TMCO3, TRPM6, TRPV4, VPS4B	228	cation transport
GO:0051180	7.658e-03	0.5886	5 CUBN, SLC19A1, SLC22A4, SLC46A1, TCN2	8	vitamin transport
GO:0030001	7.759e-03	14.64	30 ATP1B4, BDKRB1, BSPRY, CHRNA9, CYSLTR1, EGF, KCND3, KCNJ1, KCNJ16, KCNK5, LPAR3, SCNN1A, SCNN1B, SCNN1G, SGK1, SLC10A2, SLC13A3, SLC22A4, SLC30A6, SLC30A7, SLC34A1, SLC39A9, SLC40A1, SLC5A11, SLC5A12, SLC5A9, TCN2, TRPM6, TRPV4, VPS4B	199	metal ion transport
GO:0006814	7.960e-03	3.458	12 ATP1B4, SCNN1A, SCNN1B, SCNN1G, SGK1, SLC10A2, SLC13A3, SLC22A4, SLC34A1, SLC5A11, SLC5A12, SLC5A9	47	sodium ion transport
GO:0015849	8.175e-03	5.077	15 HTT, SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC17A5, SLC19A1, SLC22A4, SLC26A7, SLC27A1, SLC3A1, SLC46A1, SLC6A19, SLC7A9, THBS1	69	organic acid transport
GO:0046942	8.175e-03	5.077	15 HTT, SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC17A5, SLC19A1, SLC22A4, SLC26A7, SLC27A1, SLC3A1, SLC46A1, SLC6A19, SLC7A9, THBS1	69	carboxylic acid transport
GO:0015672	2.416e-02	8.241	19 ATP1B4, ATP6V0A4, ATP6V0D2, KCND3, KCNJ1, KCNJ16, KCNK5, SCNN1A, SCNN1B, SCNN1G, SGK1, SLC10A2, SLC13A3, SLC22A4, SLC34A1, SLC5A11, SLC5A12, SLC5A9, VPS4B	112	monovalent inorganic cation transport

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	1.776e-07	5.463	23 ATP6V0A4, ATP6V0D2, CLCN5, CUBN, DPEP1, DPP4, ENPEP, EPCAM, F2RL2, FZD6, ITGA8, LGMN, MPDZ, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC22A4, SLC46A1, SLC5A12, TRPM6, UPK3A	75	apical part of cell
GO:0016324	1.445e-06	4.297	19 ATP6V0A4, ATP6V0D2, CUBN, DPEP1, DPP4, ENPEP, EPCAM, F2RL2, MPDZ, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC22A4, SLC46A1, SLC5A12, TRPM6, UPK3A	59	apical plasma membrane
GO:0005773	2.880e-04	6.701	20 ABCA5, ACP2, AMBRA1, ARSB, ASAH1, ATP6V0A4, ATP6V0D2, C2orf18, CTBS, CUBN, GGH, LGMN, NAGA, NCSTN, SLC17A5, SLC3A1, TMEM9, TPP1, VPS39, VPS4B	92	vacuole
GO:0000323	2.452e-03	5.536	16 ABCA5, ACP2, ARSB, ASAH1, C2orf18, CTBS, CUBN, GGH, LGMN, NAGA, NCSTN, SLC17A5, TMEM9, TPP1, VPS39, VPS4B	76	lytic vacuole
GO:0005764	2.452e-03	5.536	16 ABCA5, ACP2, ARSB, ASAH1, C2orf18, CTBS, CUBN, GGH, LGMN, NAGA, NCSTN, SLC17A5, TMEM9, TPP1, VPS39, VPS4B	76	lysosome
GO:0034706	8.477e-03	0.2185	3 SCNN1A, SCNN1B, SCNN1G	3	sodium channel complex
GO:0031224	9.962e-03	117.8	147 ABCA5, ABCC4, ABCG1, ABHD6, ACER3, ACP2, ADAM19, ADIPOR1, AKAP6, ALK, ANKLE2, APLP2, AQP3, ATP1B4, ATP6V0A4, AVPR1A, B3GNT5, B4GALT5, BDKRB1, C2orf18, C6orf192, CA12, CASR, CD82, CDH6, CHRNA9, CLCN5, CLDN16, CLDN19, CLIC3, CLIC6, CNNM2, COX18, CREB3L3, CYSLTR1, DPEP1, DPP4, EGF, ENPEP, ENTPD6, EPCAM, EREG, F2RL1, F2RL2, FAAH, FRAS1, FZD6, GABRP, GALNT11, GALNT12, GALNT14, GHRHR, GPR160, GRAMD2, HM13, IFNAR1, ILDR1, ITGA8, ITGB6, KCND3, KCNJ1, KCNJ16, KCNK5, KIAA0090, KL, KLHDC7A, KMO, LPAR3, LRIG3, LRRC8B, LYPD2, LYSMD4, MARVELD3, MBOAT1, MPP1, MPZL2, NCSTN, NOX4, NRP2, P4HTM, PAQR5, PAQR9, PIGL, PLEKHH2, PRLR, PTGER4, PTPRQ, RASA3, RECK, REEP1, RHAG, RHCG, RNF144A, RNF145, SCAMP2, SCNN1A, SCNN1B, SCNN1G, SHISA2, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC17A5, SLC19A1, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC27A1, SLC30A6, SLC30A7, SLC34A1, SLC39A9, SLC3A1, SLC40A1, SLC46A1, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SPTLC2, SUSD2, TAPT1, TMCC1, TMCO3, TMEM104, TMEM171, TMEM184C, TMEM27, TMEM9, TMEM9B, TMIGD1, TMPRSS13, TMX4, TRPM6, TRPV4, TSHR, UPK3A, VAT1, WRB, XPNPEP2, YIPF1, ZDHHC13, ZPLD1	1617	intrinsic to membrane
GO:0005774	1.232e-02	3.569	11 ABCA5, ACP2, ATP6V0A4, ATP6V0D2, CUBN, NCSTN, SLC17A5, SLC3A1, TMEM9, VPS39, VPS4B	49	vacuolar membrane
GO:0044437	1.426e-02	3.642	11 ABCA5, ACP2, ATP6V0A4, ATP6V0D2, CUBN, NCSTN, SLC17A5, SLC3A1, TMEM9, VPS39, VPS4B	50	vacuolar part
GO:0016021	2.150e-02	115.4	142 ABCA5, ABCC4, ABCG1, ABHD6, ACER3, ACP2, ADAM19, ADIPOR1, AKAP6, ALK, ANKLE2, APLP2, AQP3, ATP1B4, ATP6V0A4, AVPR1A, B3GNT5, B4GALT5, BDKRB1, C2orf18, C6orf192, CA12, CASR, CD82, CDH6, CHRNA9, CLCN5, CLDN16, CLDN19, CLIC3, CLIC6, CNNM2, COX18, CREB3L3, CYSLTR1, DPP4, EGF, ENPEP, ENTPD6, EPCAM, EREG, F2RL1, F2RL2, FAAH, FRAS1, FZD6, GABRP, GALNT11, GALNT12, GALNT14, GHRHR, GPR160, GRAMD2, HM13, IFNAR1, ILDR1, ITGA8, ITGB6, KCND3, KCNJ1, KCNJ16, KCNK5, KIAA0090, KL, KLHDC7A, KMO, LPAR3, LRIG3, LRRC8B, LYSMD4, MARVELD3, MBOAT1, MPP1, MPZL2, NCSTN, NOX4, NRP2, P4HTM, PAQR5, PAQR9, PIGL, PLEKHH2, PRLR, PTGER4, PTPRQ, REEP1, RHAG, RHCG, RNF144A, RNF145, SCAMP2, SCNN1A, SCNN1B, SCNN1G, SHISA2, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC17A5, SLC19A1, SLC22A4, SLC25A40, SLC25A48, SLC26A7, SLC27A1, SLC30A6, SLC30A7, SLC34A1, SLC39A9, SLC3A1, SLC40A1, SLC46A1, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SPTLC2, SUSD2, TAPT1, TMCC1, TMCO3, TMEM104, TMEM171, TMEM184C, TMEM27, TMEM9, TMEM9B, TMIGD1, TMPRSS13, TMX4, TRPM6, TRPV4, TSHR, UPK3A, VAT1, WRB, YIPF1, ZDHHC13, ZPLD1	1584	integral to membrane

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005215	2.180e-03	33.37	57 ABCC4, ABCG1, AP1G1, AP1S3, AQP3, ATP1B4, ATP6V0A4, ATP6V0D2, CHRNA9, CLCN5, CLDN16, CLIC3, CLIC6, COX18, CSE1L, CUBN, GABRP, HTT, KCND3, KCNJ1, KCNJ16, KCNK5, KLHL2, RASA3, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC17A5, SLC19A1, SLC22A4, SLC25A48, SLC26A7, SLC27A1, SLC30A6, SLC30A7, SLC34A1, SLC39A9, SLC3A1, SLC40A1, SLC46A1, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, SNX2, TMCO3, TRPM6, TRPV4, ZDHHC13	454	transporter activity
GO:0008191	2.530e-03	0.294	4 COL4A3, LXN, RECK, TIMP3	4	metalloendopeptidase inhibitor activity
GO:0010576	2.530e-03	0.294	4 COL4A3, LXN, RECK, TIMP3	4	metalloenzyme regulator activity
GO:0048551	2.530e-03	0.294	4 COL4A3, LXN, RECK, TIMP3	4	metalloenzyme inhibitor activity
GO:0022857	5.955e-03	27.05	47 ABCC4, ABCG1, AQP3, ATP1B4, ATP6V0A4, ATP6V0D2, CHRNA9, CLCN5, CLDN16, CLIC3, CLIC6, GABRP, KCND3, KCNJ1, KCNJ16, KCNK5, RASA3, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC17A5, SLC19A1, SLC22A4, SLC26A7, SLC30A6, SLC30A7, SLC34A1, SLC39A9, SLC3A1, SLC40A1, SLC46A1, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, TMCO3, TRPM6, TRPV4, ZDHHC13	368	transmembrane transporter activity
GO:0022804	9.496e-03	9.555	22 ABCC4, ABCG1, ATP1B4, ATP6V0A4, CLCN5, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC17A5, SLC19A1, SLC22A4, SLC26A7, SLC34A1, SLC3A1, SLC5A11, SLC5A12, SLC5A9, SLC6A19, SLC7A9, TMCO3	130	active transmembrane transporter activity
GO:0022892	9.563e-03	28.52	48 ABCC4, ABCG1, AP1G1, AP1S3, AQP3, ATP1B4, ATP6V0A4, ATP6V0D2, CHRNA9, CLCN5, CLDN16, CLIC3, CLIC6, COX18, CSE1L, GABRP, KCND3, KCNJ1, KCNJ16, KCNK5, RASA3, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC17A5, SLC22A4, SLC26A7, SLC27A1, SLC30A6, SLC30A7, SLC34A1, SLC39A9, SLC3A1, SLC40A1, SLC5A9, SLC6A19, SLC7A9, SNX2, TMCO3, TRPM6, TRPV4, ZDHHC13	388	substrate-specific transporter activity
GO:0015291	1.607e-02	6.174	16 CLCN5, SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC17A5, SLC19A1, SLC22A4, SLC26A7, SLC34A1, SLC5A11, SLC5A12, SLC5A9, SLC6A19, TMCO3	84	secondary active transmembrane transporter activity
GO:0015293	2.539e-02	4.116	12 SLC10A2, SLC13A3, SLC16A12, SLC16A2, SLC16A4, SLC17A5, SLC22A4, SLC34A1, SLC5A11, SLC5A12, SLC5A9, SLC6A19	56	symporter activity
GO:0022891	3.625e-02	25.14	41 ABCC4, AQP3, ATP1B4, ATP6V0A4, ATP6V0D2, CHRNA9, CLCN5, CLDN16, CLIC3, CLIC6, GABRP, KCND3, KCNJ1, KCNJ16, KCNK5, RASA3, RHAG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC10A2, SLC13A3, SLC16A2, SLC16A4, SLC17A5, SLC22A4, SLC26A7, SLC30A6, SLC30A7, SLC34A1, SLC39A9, SLC3A1, SLC40A1, SLC5A9, SLC6A19, SLC7A9, TMCO3, TRPM6, TRPV4, ZDHHC13	342	substrate-specific transmembrane transporter activity
GO:0022890	4.241e-02	5.66	14 ATP1B4, ATP6V0A4, ATP6V0D2, CLDN16, RHAG, RHCG, SLC10A2, SLC13A3, SLC22A4, SLC30A6, SLC40A1, SLC5A9, SLC6A19, ZDHHC13	77	inorganic cation transmembrane transporter activity
GO:0004065	4.877e-02	0.294	3 ARSB, ARSK, SULF2	4	arylsulfatase activity
GO:0008484	4.877e-02	0.294	3 ARSB, ARSK, SULF2	4	sulfuric ester hydrolase activity
GO:0015101	4.877e-02	0.294	3 RHAG, RHCG, SLC22A4	4	organic cation transmembrane transporter activity
GO:0015280	4.877e-02	0.294	3 SCNN1A, SCNN1B, SCNN1G	4	amiloride-sensitive sodium channel activity

Id	Pvalue	ExpCount	Count	Size	Term
04960	4.622e-03	1.177	7 ATP1B4, HSD11B2, KCNJ1, SCNN1A, SCNN1B, SCNN1G, SGK1	16	Aldosterone-regulated sodium reabsorption
04142	3.261e-02	3.753	11 ACP2, AP1G1, AP1S3, ARSB, ASAH1, ATP6V0A4, ATP6V0D2, LGMN, NAGA, SLC17A5, TPP1	51	Lysosome

No enriched terms

No enriched terms

Entrez genes

A2LD1AIG2-like domain 1 (ENSG00000134864), score: 0.4 ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (ENSG00000154265), score: -0.45 ABCC4ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ENSG00000125257), score: 0.54 ABCG1ATP-binding cassette, sub-family G (WHITE), member 1 (ENSG00000160179), score: -0.41 ABHD6abhydrolase domain containing 6 (ENSG00000163686), score: -0.43 ACER3alkaline ceramidase 3 (ENSG00000078124), score: 0.61 ACMSDaminocarboxymuconate semialdehyde decarboxylase (ENSG00000153086), score: 0.41 ACP2acid phosphatase 2, lysosomal (ENSG00000134575), score: 0.4 ADAM19ADAM metallopeptidase domain 19 (ENSG00000135074), score: -0.41 ADIPOR1adiponectin receptor 1 (ENSG00000159346), score: 0.52 AGR2anterior gradient homolog 2 (Xenopus laevis) (ENSG00000106541), score: 0.42 AKAP6A kinase (PRKA) anchor protein 6 (ENSG00000151320), score: -0.4 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.43 ALDH6A1aldehyde dehydrogenase 6 family, member A1 (ENSG00000119711), score: 0.43 ALKanaplastic lymphoma receptor tyrosine kinase (ENSG00000171094), score: 0.59 ALKBH2alkB, alkylation repair homolog 2 (E. coli) (ENSG00000189046), score: 0.41 AMBRA1autophagy/beclin-1 regulator 1 (ENSG00000110497), score: 0.49 ANAPC2anaphase promoting complex subunit 2 (ENSG00000176248), score: -0.41 ANAPC4anaphase promoting complex subunit 4 (ENSG00000053900), score: -0.57 ANKLE2ankyrin repeat and LEM domain containing 2 (ENSG00000176915), score: -0.47 ANKRD2ankyrin repeat domain 2 (stretch responsive muscle) (ENSG00000165887), score: 0.55 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.44 AP1G1adaptor-related protein complex 1, gamma 1 subunit (ENSG00000166747), score: 0.46 AP1S3adaptor-related protein complex 1, sigma 3 subunit (ENSG00000152056), score: 0.48 APEHN-acylaminoacyl-peptide hydrolase (ENSG00000164062), score: 0.42 APLP2amyloid beta (A4) precursor-like protein 2 (ENSG00000084234), score: 0.59 AQP3aquaporin 3 (Gill blood group) (ENSG00000165272), score: 0.55 ARFIP1ADP-ribosylation factor interacting protein 1 (ENSG00000164144), score: 0.44 ARHGAP40Rho GTPase activating protein 40 (ENSG00000124143), score: 0.4 ARHGAP6Rho GTPase activating protein 6 (ENSG00000047648), score: 0.44 ARHGEF38Rho guanine nucleotide exchange factor (GEF) 38 (ENSG00000138784), score: 0.5 ARSBarylsulfatase B (ENSG00000113273), score: 0.41 ARSKarylsulfatase family, member K (ENSG00000164291), score: 0.62 ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 1 (ENSG00000104763), score: 0.78 ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ENSG00000153317), score: -0.41 ASH2Lash2 (absent, small, or homeotic)-like (Drosophila) (ENSG00000129691), score: -0.47 ASPAaspartoacylase (ENSG00000108381), score: 0.71 ASXL2additional sex combs like 2 (Drosophila) (ENSG00000143970), score: 0.41 ATG4BATG4 autophagy related 4 homolog B (S. cerevisiae) (ENSG00000168397), score: -0.42 ATP1B4ATPase, Na+/K+ transporting, beta 4 polypeptide (ENSG00000101892), score: 0.4 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.61 ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (ENSG00000147614), score: 0.47 AVPR1Aarginine vasopressin receptor 1A (ENSG00000166148), score: 0.5 B3GNT5UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 (ENSG00000176597), score: 0.42 B4GALT5UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 (ENSG00000158470), score: -0.41 BDKRB1bradykinin receptor B1 (ENSG00000100739), score: 0.5 BMP3bone morphogenetic protein 3 (ENSG00000152785), score: 0.41 BSPRYB-box and SPRY domain containing (ENSG00000119411), score: 0.42 BTKBruton agammaglobulinemia tyrosine kinase (ENSG00000010671), score: 0.46 C11orf54chromosome 11 open reading frame 54 (ENSG00000182919), score: 0.41 C1orf116chromosome 1 open reading frame 116 (ENSG00000182795), score: 0.54 C1orf83chromosome 1 open reading frame 83 (ENSG00000116205), score: 0.43 C2orf18chromosome 2 open reading frame 18 (ENSG00000213699), score: 0.6 C6orf106chromosome 6 open reading frame 106 (ENSG00000196821), score: -0.48 C6orf192chromosome 6 open reading frame 192 (ENSG00000146409), score: 0.47 C8orf42chromosome 8 open reading frame 42 (ENSG00000180190), score: 0.59 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.44 CALML4calmodulin-like 4 (ENSG00000129007), score: 0.44 CAMSAP1calmodulin regulated spectrin-associated protein 1 (ENSG00000130559), score: -0.4 CAND2cullin-associated and neddylation-dissociated 2 (putative) (ENSG00000144712), score: -0.45 CAPRIN2caprin family member 2 (ENSG00000110888), score: -0.39 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.71 CASS4Cas scaffolding protein family member 4 (ENSG00000087589), score: 0.56 CBR4carbonyl reductase 4 (ENSG00000145439), score: 0.41 CCBL1cysteine conjugate-beta lyase, cytoplasmic (ENSG00000171097), score: 0.46 CCDC127coiled-coil domain containing 127 (ENSG00000164366), score: -0.4 CCND3cyclin D3 (ENSG00000112576), score: 0.48 CCNHcyclin H (ENSG00000134480), score: -0.65 CD82CD82 molecule (ENSG00000085117), score: 0.43 CDC123cell division cycle 123 homolog (S. cerevisiae) (ENSG00000151465), score: -0.47 CDH6cadherin 6, type 2, K-cadherin (fetal kidney) (ENSG00000113361), score: 0.44 CDO1cysteine dioxygenase, type I (ENSG00000129596), score: 0.45 CDT1chromatin licensing and DNA replication factor 1 (ENSG00000167513), score: 0.41 CELF2CUGBP, Elav-like family member 2 (ENSG00000048740), score: -0.46 CHRNA9cholinergic receptor, nicotinic, alpha 9 (ENSG00000174343), score: 0.5 CIAO1cytosolic iron-sulfur protein assembly 1 (ENSG00000144021), score: 0.41 CLCN5chloride channel 5 (ENSG00000171365), score: 0.61 CLDN16claudin 16 (ENSG00000113946), score: 0.58 CLDN19claudin 19 (ENSG00000164007), score: 0.84 CLIC3chloride intracellular channel 3 (ENSG00000169583), score: 0.49 CLIC6chloride intracellular channel 6 (ENSG00000159212), score: 0.85 CLIP1CAP-GLY domain containing linker protein 1 (ENSG00000130779), score: -0.41 CLK4CDC-like kinase 4 (ENSG00000113240), score: -0.46 CLUclusterin (ENSG00000120885), score: -0.48 CNNM2cyclin M2 (ENSG00000148842), score: 0.48 COG4component of oligomeric golgi complex 4 (ENSG00000103051), score: -0.4 COL4A3collagen, type IV, alpha 3 (Goodpasture antigen) (ENSG00000169031), score: 0.67 COL4A4collagen, type IV, alpha 4 (ENSG00000081052), score: 0.71 COX18COX18 cytochrome c oxidase assembly homolog (S. cerevisiae) (ENSG00000163626), score: 0.41 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.41 CSE1LCSE1 chromosome segregation 1-like (yeast) (ENSG00000124207), score: -0.5 CTBSchitobiase, di-N-acetyl- (ENSG00000117151), score: 0.42 CTDSPLCTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (ENSG00000144677), score: 0.45 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.67 CUEDC2CUE domain containing 2 (ENSG00000107874), score: -0.47 CYSLTR1cysteinyl leukotriene receptor 1 (ENSG00000173198), score: 0.41 CYTH1cytohesin 1 (ENSG00000108669), score: -0.48 CYTIPcytohesin 1 interacting protein (ENSG00000115165), score: 0.46 DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (ENSG00000153071), score: 0.59 DAOD-amino-acid oxidase (ENSG00000110887), score: 0.54 DCLRE1ADNA cross-link repair 1A (ENSG00000198924), score: -0.47 DCLRE1BDNA cross-link repair 1B (ENSG00000118655), score: 0.45 DDA1DET1 and DDB1 associated 1 (ENSG00000130311), score: -0.4 DDX24DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 (ENSG00000089737), score: -0.39 DHDPSLdihydrodipicolinate synthase-like, mitochondrial (ENSG00000241935), score: 0.52 DPEP1dipeptidase 1 (renal) (ENSG00000015413), score: 0.45 DPP4dipeptidyl-peptidase 4 (ENSG00000197635), score: 0.52 E2F5E2F transcription factor 5, p130-binding (ENSG00000133740), score: 0.46 EEF1E1eukaryotic translation elongation factor 1 epsilon 1 (ENSG00000124802), score: -0.45 EFEMP1EGF-containing fibulin-like extracellular matrix protein 1 (ENSG00000115380), score: 0.45 EGFepidermal growth factor (ENSG00000138798), score: 0.52 EHFets homologous factor (ENSG00000135373), score: 0.49 EIF2B1eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa (ENSG00000111361), score: -0.43 ELF3E74-like factor 3 (ets domain transcription factor, epithelial-specific ) (ENSG00000163435), score: 0.41 ENPEPglutamyl aminopeptidase (aminopeptidase A) (ENSG00000138792), score: 0.42 ENTPD6ectonucleoside triphosphate diphosphohydrolase 6 (putative) (ENSG00000197586), score: -0.46 EPCAMepithelial cell adhesion molecule (ENSG00000119888), score: 0.42 EPYCepiphycan (ENSG00000083782), score: 0.51 EREGepiregulin (ENSG00000124882), score: 0.45 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.51 EXOC3exocyst complex component 3 (ENSG00000180104), score: -0.44 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.45 F2RL2coagulation factor II (thrombin) receptor-like 2 (ENSG00000164220), score: 0.5 FAAHfatty acid amide hydrolase (ENSG00000117480), score: 0.6 FAM3Dfamily with sequence similarity 3, member D (ENSG00000198643), score: 0.64 FAM63Bfamily with sequence similarity 63, member B (ENSG00000128923), score: 0.43 FAM83Bfamily with sequence similarity 83, member B (ENSG00000168143), score: 0.77 FBXO4F-box protein 4 (ENSG00000151876), score: 0.59 FERMT1fermitin family member 1 (ENSG00000101311), score: 0.54 FKBP9FK506 binding protein 9, 63 kDa (ENSG00000122642), score: 0.45 FMN1formin 1 (ENSG00000186031), score: 0.42 FOXI1forkhead box I1 (ENSG00000168269), score: 0.54 FRA10AC1fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 (ENSG00000148690), score: -0.45 FRAS1Fraser syndrome 1 (ENSG00000138759), score: 0.47 FRS3fibroblast growth factor receptor substrate 3 (ENSG00000137218), score: -0.43 FSHBfollicle stimulating hormone, beta polypeptide (ENSG00000131808), score: 0.98 FXR1fragile X mental retardation, autosomal homolog 1 (ENSG00000114416), score: -0.4 FYTTD1forty-two-three domain containing 1 (ENSG00000122068), score: -0.41 FZD6frizzled homolog 6 (Drosophila) (ENSG00000164930), score: 0.44 GABRPgamma-aminobutyric acid (GABA) A receptor, pi (ENSG00000094755), score: 0.59 GALK2galactokinase 2 (ENSG00000156958), score: 0.57 GALNT11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) (ENSG00000178234), score: 0.42 GALNT12UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) (ENSG00000119514), score: 0.41 GALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) (ENSG00000158089), score: 0.44 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.53 GCLMglutamate-cysteine ligase, modifier subunit (ENSG00000023909), score: 0.47 GCM1glial cells missing homolog 1 (Drosophila) (ENSG00000137270), score: 0.57 GDF7growth differentiation factor 7 (ENSG00000143869), score: 0.46 GGHgamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) (ENSG00000137563), score: 0.45 GHRHRgrowth hormone releasing hormone receptor (ENSG00000106128), score: 0.5 GLT25D2glycosyltransferase 25 domain containing 2 (ENSG00000198756), score: 0.41 GPR160G protein-coupled receptor 160 (ENSG00000173890), score: 0.48 GRAMD2GRAM domain containing 2 (ENSG00000175318), score: 0.48 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.43 GRK6G protein-coupled receptor kinase 6 (ENSG00000198055), score: -0.41 GSCgoosecoid homeobox (ENSG00000133937), score: 0.6 HEY1hairy/enhancer-of-split related with YRPW motif 1 (ENSG00000164683), score: -0.4 HM13histocompatibility (minor) 13 (ENSG00000101294), score: 0.42 HNF4Ghepatocyte nuclear factor 4, gamma (ENSG00000164749), score: 0.51 HOXA10homeobox A10 (ENSG00000153807), score: 0.45 HOXB7homeobox B7 (ENSG00000120087), score: 0.59 HOXD10homeobox D10 (ENSG00000128710), score: 0.62 HOXD4homeobox D4 (ENSG00000170166), score: 0.53 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.57 HSPB11heat shock protein family B (small), member 11 (ENSG00000081870), score: 0.45 HTThuntingtin (ENSG00000197386), score: -0.42 IFNAR1interferon (alpha, beta and omega) receptor 1 (ENSG00000142166), score: -0.49 IKIK cytokine, down-regulator of HLA II (ENSG00000113141), score: -0.42 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.41 IRX2iroquois homeobox 2 (ENSG00000170561), score: 0.42 ITGA8integrin, alpha 8 (ENSG00000077943), score: 0.47 ITGB1BP1integrin beta 1 binding protein 1 (ENSG00000119185), score: -0.43 ITGB6integrin, beta 6 (ENSG00000115221), score: 0.45 ITIH5inter-alpha (globulin) inhibitor H5 (ENSG00000123243), score: -0.44 KCND3potassium voltage-gated channel, Shal-related subfamily, member 3 (ENSG00000171385), score: -0.44 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.52 KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (ENSG00000153822), score: 0.51 KCNK5potassium channel, subfamily K, member 5 (ENSG00000164626), score: 0.49 KIAA0090KIAA0090 (ENSG00000127463), score: 0.54 KLklotho (ENSG00000133116), score: 0.53 KLF12Kruppel-like factor 12 (ENSG00000118922), score: -0.54 KLHDC7Akelch domain containing 7A (ENSG00000179023), score: 0.42 KLHL14kelch-like 14 (Drosophila) (ENSG00000197705), score: 0.48 KLHL2kelch-like 2, Mayven (Drosophila) (ENSG00000109466), score: -0.45 KLHL8kelch-like 8 (Drosophila) (ENSG00000145332), score: 0.64 KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (ENSG00000117009), score: 0.51 KRT23keratin 23 (histone deacetylase inducible) (ENSG00000108244), score: 0.5 KRT80keratin 80 (ENSG00000167767), score: 0.44 LAMC2laminin, gamma 2 (ENSG00000058085), score: 0.49 LAMC3laminin, gamma 3 (ENSG00000050555), score: 0.53 LEAP2liver expressed antimicrobial peptide 2 (ENSG00000164406), score: 0.41 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.57 LGMNlegumain (ENSG00000100600), score: 0.7 LOC100133692similar to cell division cycle 2-like 1 (PITSLRE proteins) (ENSG00000008128), score: -0.43 LOC100134387similar to DEAH (Asp-Glu-Ala-His) box polypeptide 40 (ENSG00000108406), score: -0.47 LPAR3lysophosphatidic acid receptor 3 (ENSG00000171517), score: 0.55 LRIG3leucine-rich repeats and immunoglobulin-like domains 3 (ENSG00000139263), score: 0.41 LRRC58leucine rich repeat containing 58 (ENSG00000163428), score: 0.56 LRRC8Bleucine rich repeat containing 8 family, member B (ENSG00000197147), score: 0.43 LXNlatexin (ENSG00000079257), score: 0.53 LYPD2LY6/PLAUR domain containing 2 (ENSG00000197353), score: 1 LYSMD4LysM, putative peptidoglycan-binding, domain containing 4 (ENSG00000183060), score: -0.54 MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 3 (ENSG00000081026), score: 0.46 MAN2B2mannosidase, alpha, class 2B, member 2 (ENSG00000013288), score: 0.48 MAP2K5mitogen-activated protein kinase kinase 5 (ENSG00000137764), score: -0.4 MARK3MAP/microtubule affinity-regulating kinase 3 (ENSG00000075413), score: -0.42 MARVELD3MARVEL domain containing 3 (ENSG00000140832), score: 0.54 MBOAT1membrane bound O-acyltransferase domain containing 1 (ENSG00000172197), score: 0.49 MCM4minichromosome maintenance complex component 4 (ENSG00000104738), score: -0.46 MED23mediator complex subunit 23 (ENSG00000112282), score: 0.5 MPDZmultiple PDZ domain protein (ENSG00000107186), score: -0.45 MPP1membrane protein, palmitoylated 1, 55kDa (ENSG00000130830), score: 0.67 MPZL2myelin protein zero-like 2 (ENSG00000149573), score: 0.44 MSRAmethionine sulfoxide reductase A (ENSG00000175806), score: 0.53 MST4serine/threonine protein kinase MST4 (ENSG00000134602), score: 0.48 MTAPmethylthioadenosine phosphorylase (ENSG00000099810), score: 0.42 MXD1MAX dimerization protein 1 (ENSG00000059728), score: -0.46 MYBv-myb myeloblastosis viral oncogene homolog (avian) (ENSG00000118513), score: 0.52 MYLIPmyosin regulatory light chain interacting protein (ENSG00000007944), score: 0.44 N6AMT2N-6 adenine-specific DNA methyltransferase 2 (putative) (ENSG00000150456), score: 0.42 NAGAN-acetylgalactosaminidase, alpha- (ENSG00000198951), score: 0.61 NARG2NMDA receptor regulated 2 (ENSG00000128915), score: -0.41 NCSTNnicastrin (ENSG00000162736), score: 0.58 NEK8NIMA (never in mitosis gene a)- related kinase 8 (ENSG00000160602), score: 0.43 NELFnasal embryonic LHRH factor (ENSG00000165802), score: -0.51 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.58 NR2C2nuclear receptor subfamily 2, group C, member 2 (ENSG00000177463), score: -0.44 NRP2neuropilin 2 (ENSG00000118257), score: 0.42 NSUN2NOP2/Sun domain family, member 2 (ENSG00000037474), score: -0.4 NUAK2NUAK family, SNF1-like kinase, 2 (ENSG00000163545), score: 0.45 OSBPL2oxysterol binding protein-like 2 (ENSG00000130703), score: -0.45 OSBPL3oxysterol binding protein-like 3 (ENSG00000070882), score: 0.5 OXSR1oxidative-stress responsive 1 (ENSG00000172939), score: 0.48 P4HTMprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) (ENSG00000178467), score: -0.49 PACS2phosphofurin acidic cluster sorting protein 2 (ENSG00000179364), score: -0.43 PAFAH2platelet-activating factor acetylhydrolase 2, 40kDa (ENSG00000158006), score: 0.49 PAQR5progestin and adipoQ receptor family member V (ENSG00000137819), score: 0.41 PAQR9progestin and adipoQ receptor family member IX (ENSG00000188582), score: 0.42 PARP6poly (ADP-ribose) polymerase family, member 6 (ENSG00000137817), score: -0.43 PCK1phosphoenolpyruvate carboxykinase 1 (soluble) (ENSG00000124253), score: 0.42 PCK2phosphoenolpyruvate carboxykinase 2 (mitochondrial) (ENSG00000100889), score: 0.44 PGM3phosphoglucomutase 3 (ENSG00000013375), score: 0.75 PGPEP1pyroglutamyl-peptidase I (ENSG00000130517), score: 0.43 PHTF2putative homeodomain transcription factor 2 (ENSG00000006576), score: -0.4 PI15peptidase inhibitor 15 (ENSG00000137558), score: 0.4 PIGLphosphatidylinositol glycan anchor biosynthesis, class L (ENSG00000108474), score: 0.44 PLCE1phospholipase C, epsilon 1 (ENSG00000138193), score: -0.42 PLEKHF2pleckstrin homology domain containing, family F (with FYVE domain) member 2 (ENSG00000175895), score: 0.6 PLEKHG1pleckstrin homology domain containing, family G (with RhoGef domain) member 1 (ENSG00000120278), score: -0.43 PLEKHH2pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 (ENSG00000152527), score: 0.52 PLS1plastin 1 (ENSG00000120756), score: 0.57 PPIGpeptidylprolyl isomerase G (cyclophilin G) (ENSG00000138398), score: -0.41 PRLRprolactin receptor (ENSG00000113494), score: 0.61 PTGER4prostaglandin E receptor 4 (subtype EP4) (ENSG00000171522), score: 0.56 PTPRQprotein tyrosine phosphatase, receptor type, Q (ENSG00000139304), score: 0.52 PYROXD2pyridine nucleotide-disulphide oxidoreductase domain 2 (ENSG00000119943), score: 0.67 RAB11ARAB11A, member RAS oncogene family (ENSG00000103769), score: 0.53 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.48 RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (ENSG00000128340), score: 0.41 RAD52RAD52 homolog (S. cerevisiae) (ENSG00000002016), score: -0.4 RANBP3RAN binding protein 3 (ENSG00000031823), score: -0.44 RASA3RAS p21 protein activator 3 (ENSG00000185989), score: -0.43 RASSF6Ras association (RalGDS/AF-6) domain family member 6 (ENSG00000169435), score: 0.49 RAVER2ribonucleoprotein, PTB-binding 2 (ENSG00000162437), score: 0.52 RBM6RNA binding motif protein 6 (ENSG00000004534), score: -0.4 RECKreversion-inducing-cysteine-rich protein with kazal motifs (ENSG00000122707), score: 0.49 REEP1receptor accessory protein 1 (ENSG00000068615), score: -0.46 RHAGRh-associated glycoprotein (ENSG00000112077), score: 0.79 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.56 RNF144Aring finger protein 144A (ENSG00000151692), score: -0.45 RNF145ring finger protein 145 (ENSG00000145860), score: -0.52 SAMD4Asterile alpha motif domain containing 4A (ENSG00000020577), score: -0.4 SCAMP2secretory carrier membrane protein 2 (ENSG00000140497), score: 0.47 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.53 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.57 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.57 SDSLserine dehydratase-like (ENSG00000139410), score: 0.53 SEMA3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F (ENSG00000001617), score: 0.49 SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 5 (ENSG00000206075), score: 0.47 SETD7SET domain containing (lysine methyltransferase) 7 (ENSG00000145391), score: -0.51 SF3B3splicing factor 3b, subunit 3, 130kDa (ENSG00000189091), score: -0.4 SGK1serum/glucocorticoid regulated kinase 1 (ENSG00000118515), score: 0.45 SGSM2small G protein signaling modulator 2 (ENSG00000141258), score: -0.43 SH3BP5SH3-domain binding protein 5 (BTK-associated) (ENSG00000131370), score: 0.75 SHISA2shisa homolog 2 (Xenopus laevis) (ENSG00000180730), score: 0.5 SIM1single-minded homolog 1 (Drosophila) (ENSG00000112246), score: 0.66 SIN3BSIN3 homolog B, transcription regulator (yeast) (ENSG00000127511), score: -0.45 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (ENSG00000125255), score: 0.68 SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (ENSG00000158296), score: 0.5 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.5 SLC16A2solute carrier family 16, member 2 (monocarboxylic acid transporter 8) (ENSG00000147100), score: 0.56 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.57 SLC17A5solute carrier family 17 (anion/sugar transporter), member 5 (ENSG00000119899), score: 0.45 SLC19A1solute carrier family 19 (folate transporter), member 1 (ENSG00000173638), score: 0.46 SLC22A4solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (ENSG00000197208), score: 0.5 SLC25A40solute carrier family 25, member 40 (ENSG00000075303), score: 0.49 SLC25A48solute carrier family 25, member 48 (ENSG00000145832), score: 0.53 SLC26A7solute carrier family 26, member 7 (ENSG00000147606), score: 0.5 SLC27A1solute carrier family 27 (fatty acid transporter), member 1 (ENSG00000130304), score: 0.72 SLC30A6solute carrier family 30 (zinc transporter), member 6 (ENSG00000152683), score: 0.41 SLC30A7solute carrier family 30 (zinc transporter), member 7 (ENSG00000162695), score: 0.47 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.68 SLC39A9solute carrier family 39 (zinc transporter), member 9 (ENSG00000029364), score: 0.57 SLC3A1solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 (ENSG00000138079), score: 0.4 SLC40A1solute carrier family 40 (iron-regulated transporter), member 1 (ENSG00000138449), score: 0.46 SLC46A1solute carrier family 46 (folate transporter), member 1 (ENSG00000076351), score: 0.53 SLC5A11solute carrier family 5 (sodium/glucose cotransporter), member 11 (ENSG00000158865), score: 0.46 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.64 SLC5A9solute carrier family 5 (sodium/glucose cotransporter), member 9 (ENSG00000117834), score: 0.61 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.67 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.52 SLIT3slit homolog 3 (Drosophila) (ENSG00000184347), score: 0.46 SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (ENSG00000153147), score: -0.41 SMYD2SET and MYND domain containing 2 (ENSG00000143499), score: -0.46 SNED1sushi, nidogen and EGF-like domains 1 (ENSG00000162804), score: -0.44 SNRPA1small nuclear ribonucleoprotein polypeptide A' (ENSG00000131876), score: -0.41 SNX2sorting nexin 2 (ENSG00000205302), score: 0.53 SPTLC2serine palmitoyltransferase, long chain base subunit 2 (ENSG00000100596), score: 0.45 SRMSsrc-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (ENSG00000125508), score: 0.6 SRSF5serine/arginine-rich splicing factor 5 (ENSG00000100650), score: -0.41 SS18synovial sarcoma translocation, chromosome 18 (ENSG00000141380), score: 0.6 STC1stanniocalcin 1 (ENSG00000159167), score: 0.55 SULF2sulfatase 2 (ENSG00000196562), score: 0.4 SUPV3L1suppressor of var1, 3-like 1 (S. cerevisiae) (ENSG00000156502), score: 0.42 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.57 SYDE2synapse defective 1, Rho GTPase, homolog 2 (C. elegans) (ENSG00000097096), score: 0.55 TAPT1transmembrane anterior posterior transformation 1 (ENSG00000169762), score: -0.46 TARSL2threonyl-tRNA synthetase-like 2 (ENSG00000185418), score: -0.5 TBC1D22BTBC1 domain family, member 22B (ENSG00000065491), score: 0.43 TCN2transcobalamin II (ENSG00000185339), score: 0.43 TECtec protein tyrosine kinase (ENSG00000135605), score: 0.44 TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (ENSG00000137203), score: 0.47 TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta) (ENSG00000008196), score: 0.41 TFAP2Ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma) (ENSG00000087510), score: 0.53 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.49 THBS1thrombospondin 1 (ENSG00000137801), score: 0.4 THNSL2threonine synthase-like 2 (S. cerevisiae) (ENSG00000144115), score: 0.4 TIMP3TIMP metallopeptidase inhibitor 3 (ENSG00000100234), score: 0.43 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.49 TMCC1transmembrane and coiled-coil domain family 1 (ENSG00000172765), score: -0.47 TMCO3transmembrane and coiled-coil domains 3 (ENSG00000150403), score: -0.44 TMEM104transmembrane protein 104 (ENSG00000109066), score: 0.52 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.57 TMEM184Ctransmembrane protein 184C (ENSG00000164168), score: 0.51 TMEM27transmembrane protein 27 (ENSG00000147003), score: 0.64 TMEM9transmembrane protein 9 (ENSG00000116857), score: -0.56 TMEM9BTMEM9 domain family, member B (ENSG00000175348), score: 0.44 TMIGD1transmembrane and immunoglobulin domain containing 1 (ENSG00000182271), score: 0.41 TMPRSS13transmembrane protease, serine 13 (ENSG00000137747), score: 0.56 TMX4thioredoxin-related transmembrane protein 4 (ENSG00000125827), score: -0.39 TOX3TOX high mobility group box family member 3 (ENSG00000103460), score: 0.43 TPP1tripeptidyl peptidase I (ENSG00000166340), score: 0.44 TRAF3TNF receptor-associated factor 3 (ENSG00000131323), score: -0.54 TRDMT1tRNA aspartic acid methyltransferase 1 (ENSG00000107614), score: 0.43 TRPM6transient receptor potential cation channel, subfamily M, member 6 (ENSG00000119121), score: 0.7 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.52 TSG101tumor susceptibility gene 101 (ENSG00000074319), score: 0.44 TSHRthyroid stimulating hormone receptor (ENSG00000165409), score: 0.62 TSTD2thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 (ENSG00000136925), score: -0.44 TTC1tetratricopeptide repeat domain 1 (ENSG00000113312), score: -0.46 TTF2transcription termination factor, RNA polymerase II (ENSG00000116830), score: 0.44 TWISTNBTWIST neighbor (ENSG00000105849), score: 0.42 UAP1L1UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (ENSG00000197355), score: 0.45 UIMC1ubiquitin interaction motif containing 1 (ENSG00000087206), score: -0.42 UPB1ureidopropionase, beta (ENSG00000100024), score: 0.43 UPK3Auroplakin 3A (ENSG00000100373), score: 0.63 USP20ubiquitin specific peptidase 20 (ENSG00000136878), score: -0.42 USP7ubiquitin specific peptidase 7 (herpes virus-associated) (ENSG00000187555), score: -0.42 VAC14Vac14 homolog (S. cerevisiae) (ENSG00000103043), score: 0.53 VAT1vesicle amine transport protein 1 homolog (T. californica) (ENSG00000108828), score: 0.48 VPS39vacuolar protein sorting 39 homolog (S. cerevisiae) (ENSG00000166887), score: -0.41 VPS4Bvacuolar protein sorting 4 homolog B (S. cerevisiae) (ENSG00000119541), score: 0.42 WDR37WD repeat domain 37 (ENSG00000047056), score: -0.43 WDR8WD repeat domain 8 (ENSG00000116213), score: -0.39 WNK1WNK lysine deficient protein kinase 1 (ENSG00000060237), score: 0.66 WNT16wingless-type MMTV integration site family, member 16 (ENSG00000002745), score: 0.57 WRBtryptophan rich basic protein (ENSG00000182093), score: -0.44 XPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (ENSG00000108039), score: 0.57 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.5 YIPF1Yip1 domain family, member 1 (ENSG00000058799), score: 0.43 YTHDC2YTH domain containing 2 (ENSG00000047188), score: -0.47 ZBED4zinc finger, BED-type containing 4 (ENSG00000100426), score: 0.6 ZBTB24zinc finger and BTB domain containing 24 (ENSG00000112365), score: 0.46 ZDHHC13zinc finger, DHHC-type containing 13 (ENSG00000177054), score: 0.6 ZNHIT6zinc finger, HIT type 6 (ENSG00000117174), score: -0.48 ZPLD1zona pellucida-like domain containing 1 (ENSG00000170044), score: 0.65

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
mdo_kd_m_ca1	mdo	kd	m	_
mdo_kd_f_ca1	mdo	kd	f	_
oan_kd_m_ca1	oan	kd	m	_
oan_kd_f_ca1	oan	kd	f	_