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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

oxidation reduction

The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons.

protein maturation by peptide bond cleavage

The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

cellular amino acid derivative metabolic process

The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.

cellular biogenic amine metabolic process

The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

bile acid biosynthetic process

The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.

cellular aromatic compound metabolic process

The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.

coenzyme metabolic process

The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

group transfer coenzyme metabolic process

NA

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

ER-nucleus signaling pathway

Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.

hemostasis

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

aromatic amino acid family metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

coenzyme biosynthetic process

The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

amine catabolic process

The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

response to biotic stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to organic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

gene expression

The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

organic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

protein processing

Any protein maturation process achieved by the cleavage of peptide bonds.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

signaling pathway

The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.

intracellular signaling pathway

The series of molecular events whereby information is sent from one location to another within a cell.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cellular response to unfolded protein

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

response to endoplasmic reticulum stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

cellular amino acid derivative catabolic process

The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

carboxylic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

coagulation

The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

cofactor biosynthetic process

The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

response to protein stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

cellular response to chemical stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

cellular response to biotic stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.

cellular response to organic substance

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

cellular response to protein stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

cellular response to biotic stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.

cellular response to chemical stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid derivative catabolic process

The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.

organic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

organic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cofactor biosynthetic process

The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

cellular response to unfolded protein

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

cellular response to unfolded protein

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

cellular response to organic substance

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

aromatic amino acid family metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

cellular biogenic amine metabolic process

The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.

cellular amino acid derivative catabolic process

The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.

aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

coenzyme biosynthetic process

The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.

endoplasmic reticulum unfolded protein response

The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

cellular response to protein stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.

aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

bile acid biosynthetic process

The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

carboxylic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

bile acid biosynthetic process

The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.

cellular response to unfolded protein

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

cell fraction

A generic term for parts of cells prepared by disruptive biochemical techniques.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

cytosol

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

peroxisome

A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

peroxisomal part

Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).

endoplasmic reticulum lumen

The volume enclosed by the membranes of the endoplasmic reticulum.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

microbody

Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

microbody part

Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

endoplasmic reticulum lumen

The volume enclosed by the membranes of the endoplasmic reticulum.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

mitochondrion

A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

microbody

Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

microbody part

Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

mitochondrial part

Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

microbody part

Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

peroxisomal part

Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

oxidoreductase activity, acting on CH-OH group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

vitamin binding

Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

amine binding

Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.

cofactor binding

Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

coenzyme binding

Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

vitamin B6 binding

Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.

all

NA

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006082	1.415e-18	18.38	67 AARS, ABHD5, ACO1, ACSL5, ACSM5, AFMID, AGXT, AKR1D1, ALDH8A1, ALDH9A1, AMDHD1, ASPG, BCKDHB, CCBL1, CCBL2, CDO1, CROT, CSGALNACT1, CTH, CYP39A1, CYP7B1, DMGDH, DPYS, EHHADH, EIF2AK3, FABP2, FAR1, FASN, FPGS, FRRS1, GAMT, GCH1, GCLM, GNE, GNMT, GPAM, GPT2, HAL, HAO1, HGD, HIBCH, HNF1A, HNF4A, IDH1, IGF1, KMO, LIPC, LPIN2, MAT1A, ME3, NPC1, NR1H3, NR1H4, NR5A2, PAH, PDP2, PEX13, PROX1, RBP4, SARDH, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2, TMEM195	228	organic acid metabolic process
GO:0019752	1.415e-18	18.38	67 AARS, ABHD5, ACO1, ACSL5, ACSM5, AFMID, AGXT, AKR1D1, ALDH8A1, ALDH9A1, AMDHD1, ASPG, BCKDHB, CCBL1, CCBL2, CDO1, CROT, CSGALNACT1, CTH, CYP39A1, CYP7B1, DMGDH, DPYS, EHHADH, EIF2AK3, FABP2, FAR1, FASN, FPGS, FRRS1, GAMT, GCH1, GCLM, GNE, GNMT, GPAM, GPT2, HAL, HAO1, HGD, HIBCH, HNF1A, HNF4A, IDH1, IGF1, KMO, LIPC, LPIN2, MAT1A, ME3, NPC1, NR1H3, NR1H4, NR5A2, PAH, PDP2, PEX13, PROX1, RBP4, SARDH, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2, TMEM195	228	carboxylic acid metabolic process
GO:0043436	1.415e-18	18.38	67 AARS, ABHD5, ACO1, ACSL5, ACSM5, AFMID, AGXT, AKR1D1, ALDH8A1, ALDH9A1, AMDHD1, ASPG, BCKDHB, CCBL1, CCBL2, CDO1, CROT, CSGALNACT1, CTH, CYP39A1, CYP7B1, DMGDH, DPYS, EHHADH, EIF2AK3, FABP2, FAR1, FASN, FPGS, FRRS1, GAMT, GCH1, GCLM, GNE, GNMT, GPAM, GPT2, HAL, HAO1, HGD, HIBCH, HNF1A, HNF4A, IDH1, IGF1, KMO, LIPC, LPIN2, MAT1A, ME3, NPC1, NR1H3, NR1H4, NR5A2, PAH, PDP2, PEX13, PROX1, RBP4, SARDH, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2, TMEM195	228	oxoacid metabolic process
GO:0042180	4.289e-18	18.78	67 AARS, ABHD5, ACO1, ACSL5, ACSM5, AFMID, AGXT, AKR1D1, ALDH8A1, ALDH9A1, AMDHD1, ASPG, BCKDHB, CCBL1, CCBL2, CDO1, CROT, CSGALNACT1, CTH, CYP39A1, CYP7B1, DMGDH, DPYS, EHHADH, EIF2AK3, FABP2, FAR1, FASN, FPGS, FRRS1, GAMT, GCH1, GCLM, GNE, GNMT, GPAM, GPT2, HAL, HAO1, HGD, HIBCH, HNF1A, HNF4A, IDH1, IGF1, KMO, LIPC, LPIN2, MAT1A, ME3, NPC1, NR1H3, NR1H4, NR5A2, PAH, PDP2, PEX13, PROX1, RBP4, SARDH, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2, TMEM195	233	cellular ketone metabolic process
GO:0044281	2.941e-11	48.52	101 A2LD1, AARS, ABCA1, ABHD5, ACO1, ACSL5, ACSM5, ADRA1B, AFMID, AGXT, AKAP12, AKR1D1, ALDH2, ALDH8A1, ALDH9A1, AMDHD1, ASPG, BCHE, BCKDHB, C14orf1, CCBL1, CCBL2, CDO1, CROT, CSGALNACT1, CTH, CYP39A1, CYP7B1, DAK, DMGDH, DPYS, EHHADH, EIF2AK3, EVI5, FABP2, FAR1, FASN, FDXR, FGD6, FPGS, FRRS1, GAMT, GBE1, GCH1, GCLM, GNAI1, GNE, GNMT, GPAM, GPT2, H6PD, HAL, HAO1, HGD, HIBCH, HMGCR, HNF1A, HNF4A, IDH1, IGF1, KMO, LCMT1, LIPC, LPIN2, MAN2A1, MAT1A, ME3, NADK, NAPRT1, NPC1, NR0B2, NR1H3, NR1H4, NR5A2, OGDHL, ONECUT1, PAH, PALM, PANK1, PANK3, PCYOX1, PDP2, PEMT, PEX13, PROX1, PYGL, RBP4, RGN, RRM1, RXRA, SARDH, SGSM3, SLC19A2, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2, TMEM195, TTPA	602	small molecule metabolic process
GO:0006519	1.088e-09	10.64	38 A2LD1, AARS, AFMID, AGXT, ALDH9A1, AMDHD1, ASPG, BCHE, BCKDHB, CCBL1, CCBL2, CDO1, CTH, DMGDH, DPYS, FRRS1, GAMT, GCH1, GCLM, GNMT, GPT2, HAL, HGD, HIBCH, HNF4A, IDH1, KMO, LIPC, MAT1A, PAH, PCYOX1, PEMT, SARDH, SLC7A2, SLC7A6, TARS, TAT, TDO2	132	cellular amino acid and derivative metabolic process
GO:0032787	1.801e-09	10.32	37 ABHD5, ACSL5, ACSM5, AGXT, AKR1D1, ALDH8A1, ALDH9A1, CROT, CSGALNACT1, CYP39A1, CYP7B1, EHHADH, EIF2AK3, FABP2, FAR1, FASN, FPGS, GCH1, GNMT, GPAM, HAO1, HNF1A, IDH1, IGF1, LIPC, LPIN2, ME3, NPC1, NR1H3, NR1H4, NR5A2, PDP2, PEX13, PROX1, RBP4, SLC35D1, TMEM195	128	monocarboxylic acid metabolic process
GO:0044106	5.131e-09	9.188	34 AARS, AFMID, AGXT, ALDH9A1, AMDHD1, ASPG, BCHE, BCKDHB, CCBL1, CCBL2, CDO1, CTH, DMGDH, DPYS, FRRS1, GCH1, GCLM, GNMT, GPT2, HAL, HGD, HIBCH, HNF4A, KMO, LIPC, MAT1A, PAH, PEMT, SARDH, SLC7A2, SLC7A6, TARS, TAT, TDO2	114	cellular amine metabolic process
GO:0006520	2.106e-08	7.254	29 AARS, AFMID, AGXT, AMDHD1, ASPG, BCKDHB, CCBL1, CCBL2, CDO1, CTH, DMGDH, DPYS, FRRS1, GCLM, GNMT, GPT2, HAL, HGD, HIBCH, HNF4A, KMO, MAT1A, PAH, SARDH, SLC7A2, SLC7A6, TARS, TAT, TDO2	90	cellular amino acid metabolic process
GO:0009308	1.997e-07	12.17	37 AARS, AFMID, AGXT, ALDH9A1, AMDHD1, ASPG, BCHE, BCKDHB, CCBL1, CCBL2, CDO1, CSGALNACT1, CTH, DMGDH, DPYS, FRRS1, GAMT, GCH1, GCLM, GNMT, GPT2, HAL, HGD, HIBCH, HNF4A, KMO, LIPC, MAT1A, PAH, PEMT, SARDH, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2	151	amine metabolic process
GO:0051186	5.516e-07	5.481	23 ACO1, ALAS1, AMBP, CPOX, CTH, FPGS, GCH1, GCLM, GPAM, H6PD, HMGCR, HNF1A, HPX, IDH1, KMO, MOCOS, MOCS1, NADK, NAPRT1, PANK1, PANK3, PDP2, TDO2	68	cofactor metabolic process
GO:0016054	7.384e-07	3.869	19 ACSL5, AFMID, AKR1D1, AMDHD1, BCKDHB, CDO1, CYP39A1, DMGDH, FRRS1, HAL, HAO1, HGD, HIBCH, KMO, PAH, PEX13, SARDH, TAT, TDO2	48	organic acid catabolic process
GO:0046395	7.384e-07	3.869	19 ACSL5, AFMID, AKR1D1, AMDHD1, BCKDHB, CDO1, CYP39A1, DMGDH, FRRS1, HAL, HAO1, HGD, HIBCH, KMO, PAH, PEX13, SARDH, TAT, TDO2	48	carboxylic acid catabolic process
GO:0009063	2.351e-06	2.257	14 AFMID, AMDHD1, BCKDHB, CDO1, DMGDH, FRRS1, HAL, HGD, HIBCH, KMO, PAH, SARDH, TAT, TDO2	28	cellular amino acid catabolic process
GO:0006575	3.449e-06	4.675	20 A2LD1, AFMID, ALDH9A1, BCHE, CCBL1, CCBL2, CDO1, CTH, DMGDH, GAMT, GCH1, GCLM, GNMT, IDH1, KMO, LIPC, PAH, PCYOX1, PEMT, TDO2	58	cellular amino acid derivative metabolic process
GO:0009310	3.833e-06	2.337	14 AFMID, AMDHD1, BCKDHB, CDO1, DMGDH, FRRS1, HAL, HGD, HIBCH, KMO, PAH, SARDH, TAT, TDO2	29	amine catabolic process
GO:0006986	4.103e-06	2.015	13 CREB3L3, DERL1, DERL2, DNAJC3, EDEM1, EDEM3, EIF2AK3, ERN1, FAF2, HERPUD1, HSPA5, TOR1A, TOR1B	25	response to unfolded protein
GO:0006732	1.058e-05	4.11	18 ACO1, CTH, FPGS, GCH1, GCLM, GPAM, H6PD, HMGCR, IDH1, KMO, MOCOS, MOCS1, NADK, NAPRT1, PANK1, PANK3, PDP2, TDO2	51	coenzyme metabolic process
GO:0006629	1.348e-05	24.9	53 ABCA1, ABHD5, ACSL5, ACSM5, AKR1D1, ALDH8A1, ASPG, BCMO1, C14orf1, CEPT1, CROT, CYP39A1, CYP7B1, EHHADH, EIF2AK3, ESR1, FABP2, FAR1, FASN, FDXR, GGPS1, GLT25D1, GM2A, GNE, GPAM, GPLD1, HAO1, HMGCR, HNF1A, HNF4A, LCLAT1, LIPC, LPGAT1, LPIN2, MTTP, NPC1, NR0B2, NR1H3, NR1H4, NR5A2, PAFAH2, PEMT, PEX13, PIP5K1B, PLA2G12B, PRLR, PROX1, RBP4, RXRA, SDR42E1, STARD5, TMEM195, TTPA	309	lipid metabolic process
GO:0055114	3.093e-05	15.56	38 AKR1D1, ALDH2, ALDH8A1, ALDH9A1, BCKDHB, BCMO1, CDO1, CPOX, CYB5A, CYBB, CYBRD1, CYP39A1, CYP7B1, DECR2, DMGDH, EHHADH, FAR1, FASN, FDXR, FRRS1, GCLM, H6PD, HAO1, HGD, HMGCR, IDH1, IYD, KMO, ME3, OGDHL, PAH, PCYOX1, PDIA5, RRM1, SARDH, SDR42E1, TDO2, TMEM195	193	oxidation reduction
GO:0008206	5.314e-05	0.8866	8 AKR1D1, CYP39A1, CYP7B1, HNF1A, NPC1, NR1H4, NR5A2, PROX1	11	bile acid metabolic process
GO:0009074	6.193e-05	0.4836	6 AFMID, HGD, KMO, PAH, TAT, TDO2	6	aromatic amino acid family catabolic process
GO:0042221	1.276e-04	42.07	73 ABCC1, ABCG5, ACO1, ACSL5, ADRA1B, AGXT, AHR, ALDH2, AQP8, BCHE, BCKDHB, C5, CASP8, CCRL1, CDO1, CHUK, CNR2, CPB2, CPOX, CREB3L3, CYBRD1, CYP7B1, DERL1, DERL2, DNAJC3, DPP4, EDEM1, EDEM3, EGFR, EIF2AK3, ERN1, ESR1, FAF2, FGB, FGG, GCH1, GCLM, GPAM, HAO1, HERPUD1, HNF1A, HNF4A, HPX, HSPA5, IDH1, INPP5K, IRF8, JAG2, LATS1, LIFR, LYN, NAPRT1, NEDD4, NPC1, NR0B2, NR1H3, NR1H4, PEMT, PIK3R3, PLAT, PPP1R15B, PRKAR1B, PSEN2, RBP4, RXRA, SERPINC1, SLIT3, TAT, TOR1A, TOR1B, TRPA1, TTPA, XCR1	522	response to chemical stimulus
GO:0006950	1.744e-04	49.65	82 AHR, ALB, ALDH2, AMBP, C5, C8A, C8B, C8G, CASP8, CDO1, CHUK, CNR2, CPB2, CREB3L3, CYBB, DERL1, DERL2, DNAJC3, DPP4, EDEM1, EDEM3, EGFR, EIF2AK3, ERN1, F10, F2, F9, FAF2, FGB, FGG, FN1, GCH1, GCLM, GPAM, HAO1, HERPUD1, HNF1A, HNF4A, HPX, HRG, HSPA5, IDH1, IFIH1, IGF1, IKBKE, IL12B, IL1RAP, IL22RA2, INHBA, IRF8, JAG2, KMO, LEAP2, LYN, MAP3K13, MASP2, MBIP, MIA3, NAPRT1, NDRG4, NEDD4, NPC1, PDIA5, PLAT, PPP1R15B, PROZ, PSEN2, RXRA, SERPINA10, SERPINC1, SNN, STAB2, TAT, TIRAP, TM4SF4, TOR1A, TOR1B, TRPA1, UVRAG, VSIG4, VTN, XCR1	616	response to stress
GO:0009607	1.857e-04	9.349	26 ALDH2, CASP8, CHUK, CNR2, CREB3L3, DERL1, DERL2, DNAJC3, EDEM1, EDEM3, EIF2AK3, ERN1, FAF2, GCH1, GPAM, HERPUD1, HSPA5, IFIH1, IL12B, IRF8, LEAP2, NR1H4, PPP1R15B, STAB2, TOR1A, TOR1B	116	response to biotic stimulus
GO:0006725	2.562e-04	3.707	15 AFMID, DPYS, FPGS, GCH1, GNMT, HGD, KMO, MOCOS, MOCS1, PAH, PCBD2, PEMT, SLC19A2, TAT, TDO2	46	cellular aromatic compound metabolic process
GO:0009069	2.902e-04	0.5642	6 AGXT, CDO1, CTH, DMGDH, GCLM, SARDH	7	serine family amino acid metabolic process
GO:0044282	4.490e-04	12.33	30 A2LD1, ACSL5, AFMID, AKR1D1, AMDHD1, BCKDHB, CDO1, CYP39A1, DMGDH, DPYS, EVI5, FGD6, FRRS1, GCH1, H6PD, HAL, HAO1, HGD, HIBCH, IGF1, KMO, OGDHL, PAH, PCYOX1, PEX13, RGN, SARDH, SGSM3, TAT, TDO2	153	small molecule catabolic process
GO:0006957	5.004e-04	0.403	5 C5, C8A, C8B, C8G, VSIG4	5	complement activation, alternative pathway
GO:0051789	5.953e-04	3.063	13 CREB3L3, DERL1, DERL2, DNAJC3, EDEM1, EDEM3, EIF2AK3, ERN1, FAF2, HERPUD1, HSPA5, TOR1A, TOR1B	38	response to protein stimulus
GO:0006066	6.321e-04	13.86	32 ABCA1, ADRA1B, AKR1D1, ALDH2, BCHE, C14orf1, CSGALNACT1, CYP39A1, CYP7B1, DAK, DMGDH, FDXR, GBE1, GCH1, GNE, GNMT, H6PD, HAO1, HMGCR, HNF1A, IGF1, LIPC, MAN2A1, NR0B2, OGDHL, ONECUT1, PAH, PEMT, PYGL, RBP4, RXRA, SLC35D1	172	alcohol metabolic process
GO:0050896	7.492e-04	85.35	121 ABCC1, ABCG5, ACO1, ACSL5, ADRA1B, AGXT, AHR, ALB, ALDH2, AMBP, AQP8, BBS2, BCHE, BCKDHB, C5, C8A, C8B, C8G, CASP8, CCRL1, CDO1, CHUK, CNR2, CPB2, CPOX, CREB3L3, CYBB, CYBRD1, CYP7B1, DERL1, DERL2, DNAJC3, DPP4, EDEM1, EDEM3, EGFR, EIF2AK3, ERN1, ESR1, F10, F2, F9, FAF2, FGB, FGG, FN1, GCH1, GCLM, GM2A, GPAM, HAO1, HERPUD1, HNF1A, HNF4A, HPX, HRG, HSPA5, ICOS, IDH1, IFIH1, IGF1, IGSF6, IKBKE, IL12B, IL1RAP, IL22RA2, INHBA, INPP5K, IRF8, JAG2, KMO, LATS1, LCP1, LEAP2, LHX8, LIFR, LYN, MAP3K13, MASP2, MBIP, MIA3, NAPRT1, NDRG4, NEDD4, NPC1, NR0B2, NR1H3, NR1H4, PDE6D, PDIA5, PEMT, PEX13, PIK3R3, PLAT, PPP1R15B, PRKAR1B, PROZ, PSEN2, RBP4, RXRA, SERPINA10, SERPINC1, SLC24A6, SLIT3, SNN, STAB2, TAT, TCF7, TIRAP, TM4SF4, TOR1A, TOR1B, TRPA1, TTPA, UNC119, UVRAG, VSIG4, VTN, WDR36, XCR1, ZAP70	1059	response to stimulus
GO:0006956	8.611e-04	0.6448	6 C5, C8A, C8B, C8G, MASP2, VSIG4	8	complement activation
GO:0019439	8.611e-04	0.6448	6 AFMID, HGD, KMO, PAH, TAT, TDO2	8	aromatic compound catabolic process
GO:0008202	8.951e-04	6.206	19 ABCA1, AKR1D1, C14orf1, CYP39A1, CYP7B1, ESR1, FDXR, HMGCR, HNF1A, LIPC, NPC1, NR0B2, NR1H4, NR5A2, PRLR, PROX1, RXRA, SDR42E1, STARD5	77	steroid metabolic process
GO:0016053	1.017e-03	4.675	16 ABHD5, AGXT, AKR1D1, CDO1, CTH, CYP39A1, CYP7B1, FAR1, FASN, HNF1A, LIPC, NR1H3, PAH, PROX1, SLC35D1, TMEM195	58	organic acid biosynthetic process
GO:0046394	1.017e-03	4.675	16 ABHD5, AGXT, AKR1D1, CDO1, CTH, CYP39A1, CYP7B1, FAR1, FASN, HNF1A, LIPC, NR1H3, PAH, PROX1, SLC35D1, TMEM195	58	carboxylic acid biosynthetic process
GO:0051188	1.021e-03	3.224	13 ALAS1, CPOX, FPGS, GCH1, GCLM, HNF1A, KMO, MOCOS, MOCS1, NAPRT1, PANK1, PANK3, PDP2	40	cofactor biosynthetic process
GO:0010033	1.864e-03	26.92	49 ACSL5, ADRA1B, AGXT, ALDH2, AQP8, BCHE, BCKDHB, CASP8, CDO1, CHUK, CNR2, CREB3L3, CYP7B1, DERL1, DERL2, DNAJC3, EDEM1, EDEM3, EGFR, EIF2AK3, ERN1, ESR1, FAF2, GCH1, GPAM, HERPUD1, HNF1A, HNF4A, HPX, HSPA5, INPP5K, IRF8, LATS1, LIFR, LYN, NR0B2, NR1H3, NR1H4, PEMT, PIK3R3, PLAT, PRKAR1B, RBP4, RXRA, SLIT3, TAT, TOR1A, TOR1B, XCR1	334	response to organic substance
GO:0002455	1.995e-03	0.7254	6 C5, C8A, C8B, C8G, HPX, MASP2	9	humoral immune response mediated by circulating immunoglobulin
GO:0002541	1.995e-03	0.7254	6 C5, C8A, C8B, C8G, MASP2, VSIG4	9	activation of plasma proteins involved in acute inflammatory response
GO:0009072	1.995e-03	0.7254	6 AFMID, HGD, KMO, PAH, TAT, TDO2	9	aromatic amino acid family metabolic process
GO:0006699	2.050e-03	0.4836	5 AKR1D1, CYP39A1, CYP7B1, HNF1A, PROX1	6	bile acid biosynthetic process
GO:0006958	2.050e-03	0.4836	5 C5, C8A, C8B, C8G, MASP2	6	complement activation, classical pathway
GO:0008610	2.109e-03	11.53	27 ABHD5, ACSL5, AKR1D1, ALDH8A1, C14orf1, CEPT1, CYP39A1, CYP7B1, FAR1, FASN, FDXR, GGPS1, GLT25D1, GNE, GPAM, HMGCR, HNF1A, LCLAT1, LIPC, LPGAT1, NR1H3, PEMT, PRLR, PROX1, SDR42E1, STARD5, TMEM195	143	lipid biosynthetic process
GO:0050817	3.083e-03	4.11	14 CPB2, F10, F2, F9, FGB, FGG, HNF4A, HRG, IL22RA2, PLAT, PROZ, PSEN2, SERPINC1, VTN	51	coagulation
GO:0009108	4.576e-03	2.337	10 FPGS, GCH1, GCLM, KMO, MOCOS, MOCS1, NAPRT1, PANK1, PANK3, PDP2	29	coenzyme biosynthetic process
GO:0065008	4.892e-03	50.78	77 A1CF, ABCA1, ABCA12, ABCG5, ABHD5, ADRA1B, AKR1D1, ALB, ALDH8A1, ALDH9A1, BBS2, CAPRIN2, CDO1, CHUK, CLCN6, CNR2, CPB2, CPE, CTH, DEPDC6, DERL1, DERL2, EIF2AK3, ESR1, F10, F2, F9, FGB, FGD6, FGG, FN1, GCH1, GCHFR, GCLM, GDF2, GPAM, HERPUD1, HNF1A, HNF4A, HPX, HRG, HTRA1, IGF1, IL22RA2, INHBA, INPP5K, LATS1, LIPC, LYN, NDRG4, NPC1, NR0B2, NR5A2, OBFC1, PAH, PALM, PDIA3, PDIA5, PDIA6, PLAT, PRLR, PROZ, PSEN2, PYGL, RBP4, RDX, RGN, SERPINC1, SFXN1, SLC26A5, SLC30A7, SLIT3, SPTBN1, SUN1, TBX3, VTN, XCR1	630	regulation of biological quality
GO:0006752	5.277e-03	0.5642	5 FPGS, GCH1, HMGCR, PANK1, PANK3	7	group transfer coenzyme metabolic process
GO:0042219	5.277e-03	0.5642	5 A2LD1, AFMID, KMO, PCYOX1, TDO2	7	cellular amino acid derivative catabolic process
GO:0030968	6.916e-03	0.8866	6 DERL1, DERL2, EIF2AK3, ERN1, HERPUD1, HSPA5	11	endoplasmic reticulum unfolded protein response
GO:0034620	6.916e-03	0.8866	6 DERL1, DERL2, EIF2AK3, ERN1, HERPUD1, HSPA5	11	cellular response to unfolded protein
GO:0071216	7.032e-03	1.612	8 DERL1, DERL2, EIF2AK3, ERN1, HERPUD1, HSPA5, IRF8, PPP1R15B	20	cellular response to biotic stimulus
GO:0007596	7.057e-03	3.949	13 CPB2, F10, F2, F9, FGB, FGG, HNF4A, HRG, IL22RA2, PLAT, PROZ, SERPINC1, VTN	49	blood coagulation
GO:0050878	7.535e-03	6.206	17 CDO1, CHUK, CPB2, EIF2AK3, F10, F2, F9, FGB, FGG, HNF4A, HRG, IL22RA2, PLAT, PRLR, PROZ, SERPINC1, VTN	77	regulation of body fluid levels
GO:0009056	7.800e-03	33.53	55 A2LD1, ABHD5, ACO1, ACSL5, ADRA1B, AFMID, AKR1D1, AMBP, AMDHD1, ASPG, BCKDHB, CASP8, CDO1, CYP39A1, DERL1, DERL2, DMGDH, DNAJC3, DPYS, EDEM1, EVI5, FGD6, FRRS1, GCH1, GM2A, H6PD, HAL, HAO1, HGD, HIBCH, HSPA5, IDH1, IGF1, KMO, LIPC, LYSMD3, NEDD4, NPC1, OGDHL, PAFAH2, PAH, PCYOX1, PEX13, PLA2G12B, PSEN2, PSMA4, PSMD1, PSMD12, PYGL, RGN, SARDH, SGSM3, TAT, TDO2, TRIB2	416	catabolic process
GO:0044248	7.969e-03	28.05	48 A2LD1, ABHD5, ACO1, ACSL5, ADRA1B, AFMID, AKR1D1, AMBP, AMDHD1, BCKDHB, CASP8, CDO1, CYP39A1, DERL1, DERL2, DMGDH, DNAJC3, DPYS, EDEM1, EVI5, FGD6, FRRS1, GCH1, GM2A, HAL, HAO1, HGD, HIBCH, HSPA5, IDH1, IGF1, KMO, LIPC, NEDD4, NPC1, PAH, PCYOX1, PEX13, PSEN2, PSMA4, PSMD1, PSMD12, RGN, SARDH, SGSM3, TAT, TDO2, TRIB2	348	cellular catabolic process
GO:0006955	8.167e-03	14.02	29 AMBP, C5, C8A, C8B, C8G, CCRL1, CHUK, CNR2, CYBB, DPP4, GCH1, GPAM, HPX, ICOS, IFIH1, IGSF6, IKBKE, IL12B, IL1RAP, IRF8, LCP1, MASP2, PSEN2, RBP4, TCF7, TIRAP, VSIG4, VTN, ZAP70	174	immune response
GO:0007599	8.432e-03	4.03	13 CPB2, F10, F2, F9, FGB, FGG, HNF4A, HRG, IL22RA2, PLAT, PROZ, SERPINC1, VTN	50	hemostasis
GO:0006576	9.657e-03	2.579	10 AFMID, ALDH9A1, BCHE, DMGDH, GCH1, KMO, LIPC, PAH, PEMT, TDO2	32	cellular biogenic amine metabolic process
GO:0044283	1.064e-02	14.99	30 ABCA1, ABHD5, AGXT, AKAP12, AKR1D1, ALDH8A1, CDO1, CTH, CYP39A1, CYP7B1, FAR1, FASN, GAMT, GCH1, GCLM, GNAI1, GNMT, HNF1A, KMO, LIPC, NAPRT1, NR1H3, PAH, PALM, PROX1, PYGL, RBP4, RRM1, SLC35D1, TMEM195	186	small molecule biosynthetic process
GO:0019438	1.077e-02	0.6448	5 GCH1, MOCOS, MOCS1, PAH, PCBD2	8	aromatic compound biosynthetic process
GO:0042558	1.077e-02	0.6448	5 GCH1, MOCOS, MOCS1, PAH, PCBD2	8	pteridine and derivative metabolic process
GO:0090208	1.306e-02	0.403	4 ABHD5, ACSL5, GPAM, NR1H3	5	positive regulation of triglyceride metabolic process
GO:0006984	1.331e-02	1.37	7 DERL1, DERL2, EIF2AK3, ERN1, HERPUD1, HSPA5, PPP1R15B	17	ER-nucleus signaling pathway
GO:0034976	1.331e-02	1.37	7 DERL1, DERL2, EIF2AK3, ERN1, HERPUD1, HSPA5, PPP1R15B	17	response to endoplasmic reticulum stress
GO:0055088	1.331e-02	1.37	7 ABCA1, ABCG5, GPAM, HNF4A, LIPC, NPC1, NR5A2	17	lipid homeostasis
GO:0006886	1.359e-02	13.14	27 AGXT, AKAP12, AP3M1, ARCN1, C16orf70, COPB1, COPB2, DERL1, DERL2, EGFR, F2, GRPEL2, KATNB1, LCP1, NEDD4, PARD3, PDIA3, PEX13, PEX16, SAR1B, SEC23A, SEC24D, SEC63, SPTBN1, SSR1, SSR3, USO1	163	intracellular protein transport
GO:0045087	1.385e-02	4.272	13 C5, C8A, C8B, C8G, CYBB, GCH1, HPX, IFIH1, IL12B, IL1RAP, MASP2, TIRAP, VSIG4	53	innate immune response
GO:0016125	1.430e-02	3.224	11 ABCA1, AKR1D1, C14orf1, CYP39A1, CYP7B1, FDXR, HMGCR, HNF1A, LIPC, NR0B2, RXRA	40	sterol metabolic process
GO:0006631	1.606e-02	6.69	17 ABHD5, ACSL5, ACSM5, CROT, EHHADH, EIF2AK3, FABP2, FAR1, FASN, GPAM, HAO1, HNF1A, LIPC, LPIN2, NR1H3, PEX13, TMEM195	83	fatty acid metabolic process
GO:0010876	1.624e-02	4.916	14 ABCA1, ABCA12, ABCD3, ABCG5, ABHD5, ACSL5, GM2A, HNF1A, INHBA, LIPC, NPC1, NR1H3, RBP4, STARD5	61	lipid localization
GO:0044255	1.921e-02	16.36	31 ABHD5, ACSL5, ACSM5, ALDH8A1, BCMO1, CEPT1, CROT, EHHADH, EIF2AK3, FABP2, FAR1, FASN, GGPS1, GLT25D1, GM2A, GNE, GPAM, GPLD1, HAO1, HMGCR, HNF1A, LCLAT1, LIPC, LPGAT1, LPIN2, NR1H3, PEMT, PEX13, PIP5K1B, RBP4, TMEM195	203	cellular lipid metabolic process
GO:0034613	2.199e-02	15.07	29 AGXT, AKAP12, AP3M1, ARCN1, BBS2, C16orf70, COPB1, COPB2, DERL1, DERL2, EGFR, F2, GRPEL2, KATNB1, LCP1, NEDD4, PARD3, PDIA3, PEX13, PEX16, SAR1B, SEC23A, SEC24D, SEC63, SPTBN1, SSR1, SSR3, SUN1, USO1	187	cellular protein localization
GO:0006694	2.417e-02	3.466	11 AKR1D1, C14orf1, CYP39A1, CYP7B1, FDXR, HMGCR, HNF1A, PRLR, PROX1, SDR42E1, STARD5	43	steroid biosynthetic process
GO:0006081	2.481e-02	1.128	6 AGXT, ALDH8A1, ALDH9A1, HAO1, IDH1, RBP4	14	cellular aldehyde metabolic process
GO:0051591	2.481e-02	1.128	6 AGXT, AQP8, BCKDHB, CDO1, CYP7B1, PLAT	14	response to cAMP
GO:0071445	2.481e-02	1.128	6 DERL1, DERL2, EIF2AK3, ERN1, HERPUD1, HSPA5	14	cellular response to protein stimulus
GO:0070727	2.515e-02	15.23	29 AGXT, AKAP12, AP3M1, ARCN1, BBS2, C16orf70, COPB1, COPB2, DERL1, DERL2, EGFR, F2, GRPEL2, KATNB1, LCP1, NEDD4, PARD3, PDIA3, PEX13, PEX16, SAR1B, SEC23A, SEC24D, SEC63, SPTBN1, SSR1, SSR3, SUN1, USO1	189	cellular macromolecule localization
GO:0008203	2.632e-02	2.982	10 ABCA1, AKR1D1, CYP39A1, CYP7B1, FDXR, HMGCR, HNF1A, LIPC, NR0B2, RXRA	37	cholesterol metabolic process
GO:0006534	2.736e-02	0.2418	3 CDO1, CTH, GCLM	3	cysteine metabolic process
GO:0006558	2.736e-02	0.2418	3 HGD, PAH, TAT	3	L-phenylalanine metabolic process
GO:0006559	2.736e-02	0.2418	3 HGD, PAH, TAT	3	L-phenylalanine catabolic process
GO:0006569	2.736e-02	0.2418	3 AFMID, KMO, TDO2	3	tryptophan catabolic process
GO:0015936	2.736e-02	0.2418	3 HMGCR, PANK1, PANK3	3	coenzyme A metabolic process
GO:0033865	2.736e-02	0.2418	3 HMGCR, PANK1, PANK3	3	nucleoside bisphosphate metabolic process
GO:0042436	2.736e-02	0.2418	3 AFMID, KMO, TDO2	3	indole derivative catabolic process
GO:0046218	2.736e-02	0.2418	3 AFMID, KMO, TDO2	3	indolalkylamine catabolic process
GO:0070189	2.736e-02	0.2418	3 CCBL1, CCBL2, KMO	3	kynurenine metabolic process
GO:0042060	2.745e-02	7.093	17 CPB2, F10, F2, F9, FGB, FGG, HNF4A, HRG, IGF1, IL22RA2, MIA3, PLAT, PROZ, SERPINA10, SERPINC1, TM4SF4, VTN	88	wound healing
GO:0019835	2.840e-02	0.4836	4 C5, C8A, C8B, C8G	6	cytolysis
GO:0090207	2.840e-02	0.4836	4 ABHD5, ACSL5, GPAM, NR1H3	6	regulation of triglyceride metabolic process
GO:0009611	3.174e-02	17.01	31 C5, C8A, C8B, C8G, CDO1, CNR2, CPB2, CYBB, F10, F2, F9, FGB, FGG, FN1, HNF4A, HRG, IGF1, IL1RAP, IL22RA2, MASP2, MIA3, PLAT, PROZ, RXRA, SERPINA10, SERPINC1, TIRAP, TM4SF4, VSIG4, VTN, XCR1	211	response to wounding
GO:0046483	3.174e-02	17.01	31 ABCA1, AFMID, AKAP12, ALAS1, AMBP, AMDHD1, BCHE, CPOX, DPYS, EVI5, FGD6, FPGS, FRRS1, GCH1, GNAI1, HAL, HNF1A, HPX, KMO, MOCOS, MOCS1, NADK, PAH, PALM, PCBD2, PYGL, RGN, SGSM3, SLC19A2, TDO2, TTPA	211	heterocycle metabolic process
GO:0006959	3.196e-02	1.612	7 C5, C8A, C8B, C8G, HPX, MASP2, VSIG4	20	humoral immune response
GO:0006790	3.798e-02	3.707	11 CDO1, CSGALNACT1, CTH, GCLM, GNMT, IDH1, IGF1, PAPSS2, PEMT, SLC19A2, SLC35D1	46	sulfur metabolic process
GO:0018130	4.085e-02	1.693	7 ALAS1, CPOX, GCH1, HNF1A, MOCOS, MOCS1, PCBD2	21	heterocycle biosynthetic process
GO:0051605	4.204e-02	2.176	8 C5, C8A, C8B, C8G, CPE, MASP2, PSEN2, VSIG4	27	protein maturation by peptide bond cleavage
GO:0042168	4.472e-02	0.8866	5 ALAS1, AMBP, CPOX, HNF1A, HPX	11	heme metabolic process
GO:0042632	4.472e-02	0.8866	5 ABCA1, ABCG5, LIPC, NPC1, NR5A2	11	cholesterol homeostasis
GO:0055092	4.472e-02	0.8866	5 ABCA1, ABCG5, LIPC, NPC1, NR5A2	11	sterol homeostasis
GO:0042559	4.994e-02	0.5642	4 GCH1, MOCOS, MOCS1, PCBD2	7	pteridine and derivative biosynthetic process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0044432	4.610e-08	17.87	47 ACSL5, ATL2, BCHE, C14orf1, CEPT1, CLSTN1, CREB3L3, CYB5A, CYP39A1, CYP7B1, DERL1, DERL2, DNAJC3, EDEM1, EDEM3, EIF2AK3, ERN1, GJB1, GLT25D1, H6PD, HERPUD1, HMGCR, HSPA5, LCLAT1, LPGAT1, LPIN2, MARCH5, MIA3, PDIA3, PDIA5, PDIA6, PEMT, PEX16, PSEN2, RNF43, SAR1B, SEC16B, SEC23A, SEC24D, SEC63, SLC33A1, SLC35D1, SSR1, SSR3, TOR1A, TOR1B, YIPF5	227	endoplasmic reticulum part
GO:0071212	2.313e-07	18.82	47 ACSL5, ATL2, BCHE, C14orf1, CEPT1, CLSTN1, CREB3L3, CYB5A, CYP39A1, CYP7B1, DERL1, DERL2, DNAJC3, EDEM1, EDEM3, EIF2AK3, ERN1, GJB1, GLT25D1, H6PD, HERPUD1, HMGCR, HSPA5, LCLAT1, LPGAT1, LPIN2, MARCH5, MIA3, PDIA3, PDIA5, PDIA6, PEMT, PEX16, PSEN2, RNF43, SAR1B, SEC16B, SEC23A, SEC24D, SEC63, SLC33A1, SLC35D1, SSR1, SSR3, TOR1A, TOR1B, YIPF5	239	subsynaptic reticulum
GO:0005783	1.229e-06	28.03	59 A1CF, ACO1, ACSL5, ATL2, BCHE, C14orf1, CEPT1, CLSTN1, CREB3L3, CYB5A, CYP39A1, CYP7B1, DERL1, DERL2, DNAJC3, DPP4, EDEM1, EDEM3, EIF2AK3, ERN1, FAF2, GJB1, GLT25D1, H6PD, HERPUD1, HMGCR, HSPA5, INPP5K, KIFAP3, LCLAT1, LPGAT1, LPIN2, MARCH5, MIA3, MTTP, NPC1, PDIA3, PDIA5, PDIA6, PEMT, PEX16, PLA2G12B, PSEN2, RNF43, SAR1B, SEC16B, SEC23A, SEC24D, SEC63, SLC33A1, SLC35D1, SLC39A6, SSR1, SSR3, TMEM117, TMEM195, TOR1A, TOR1B, YIPF5	356	endoplasmic reticulum
GO:0044444	1.605e-06	145.2	197 A1CF, ABCA1, ABCD3, ABHD5, ACO1, ACSL5, ACSM5, AFMID, AGXT, AKAP12, AKR1D1, ALAS1, ALB, ALDH2, ALDH9A1, AMDHD1, AP3M1, ARCN1, ARFGEF2, ATL2, ATPAF1, B4GALT2, BACH1, BBS2, BCHE, BCKDHB, BPNT1, C13orf15, C14orf1, C16orf70, C2CD2, C5orf33, CAPRIN2, CASP8, CCBL1, CCBL2, CDK14, CDO1, CEPT1, CHUK, CKAP5, CLCN6, CLSTN1, COPB1, COPB2, CPOX, CREB3L3, CROT, CSGALNACT1, CTNNAL1, CYB5A, CYBB, CYP39A1, CYP7B1, DECR2, DERL1, DERL2, DMGDH, DNAJC3, DNMBP, DPP4, DPYS, EDEM1, EDEM3, EGFR, EHHADH, EIF2AK3, ERN1, EVI5, FABP2, FAF2, FAR1, FASN, FDXR, FGB, FGD6, FGG, FN1, FNDC3A, FPGS, GAMT, GBE1, GCH1, GCHFR, GCLM, GJB1, GLT25D1, GM2A, GNE, GNMT, GPAM, GPT2, GRPEL2, H6PD, HAL, HAO1, HERPUD1, HIBCH, HMGCR, HRG, HSPA5, IDH1, IFT57, IGF1, IKBKE, IL22RA2, INPP5K, JAG2, KATNB1, KIFAP3, KMO, LATS1, LCLAT1, LCP1, LPGAT1, LPIN2, LYN, LZTS2, MAN2A1, MAP3K13, MARCH5, ME3, MIA3, MTTP, MUT, NADK, NAPRT1, NEDD4, NPC1, NUFIP2, OGDHL, PALM, PANK1, PARD3, PCBD2, PCYOX1, PDIA3, PDIA5, PDIA6, PDP2, PEMT, PEX11G, PEX13, PEX16, PIK3R3, PLA2G12B, PLAT, PPP1R15B, PRKAR1B, PSEN2, PSTPIP2, RANBP10, RDX, RNF43, RRM1, SAR1B, SARDH, SEC16B, SEC23A, SEC24D, SEC63, SERINC3, SFXN1, SIRT3, SLC17A8, SLC25A16, SLC25A21, SLC25A40, SLC25A47, SLC2A2, SLC30A7, SLC33A1, SLC35D1, SLC39A6, SLIT3, SNN, SPIRE1, SPTBN1, SSR1, SSR3, STARD5, TARS, TAT, TDO2, TJAP1, TMEM117, TMEM195, TOR1A, TOR1B, TTPA, TUBE1, UNC119, USO1, UVRAG, WLS, YIPF5, ZAP70	1844	cytoplasmic part
GO:0005789	1.000e-05	15.59	38 ACSL5, ATL2, C14orf1, CEPT1, CLSTN1, CREB3L3, CYB5A, CYP39A1, CYP7B1, DERL1, DERL2, DNAJC3, EDEM1, EIF2AK3, ERN1, GJB1, HERPUD1, HMGCR, HSPA5, LCLAT1, LPGAT1, LPIN2, MARCH5, MIA3, PEMT, PEX16, PSEN2, RNF43, SAR1B, SEC16B, SEC23A, SEC24D, SEC63, SLC33A1, SLC35D1, SSR1, SSR3, YIPF5	198	endoplasmic reticulum membrane
GO:0042175	2.051e-05	16.06	38 ACSL5, ATL2, C14orf1, CEPT1, CLSTN1, CREB3L3, CYB5A, CYP39A1, CYP7B1, DERL1, DERL2, DNAJC3, EDEM1, EIF2AK3, ERN1, GJB1, HERPUD1, HMGCR, HSPA5, LCLAT1, LPGAT1, LPIN2, MARCH5, MIA3, PEMT, PEX16, PSEN2, RNF43, SAR1B, SEC16B, SEC23A, SEC24D, SEC63, SLC33A1, SLC35D1, SSR1, SSR3, YIPF5	204	nuclear membrane-endoplasmic reticulum network
GO:0005777	1.763e-04	2.598	12 ABCD3, AGXT, CROT, DECR2, EHHADH, FAR1, HAO1, HMGCR, IDH1, PEX11G, PEX13, PEX16	33	peroxisome
GO:0042579	1.763e-04	2.598	12 ABCD3, AGXT, CROT, DECR2, EHHADH, FAR1, HAO1, HMGCR, IDH1, PEX11G, PEX13, PEX16	33	microbody
GO:0005829	5.886e-04	35.2	60 ABHD5, ACO1, AFMID, AKR1D1, ALDH9A1, AMDHD1, ARCN1, ARFGEF2, BACH1, BPNT1, C2CD2, CASP8, CCBL1, CDK14, CDO1, CHUK, CKAP5, COPB1, COPB2, CTNNAL1, DPYS, FASN, FNDC3A, FPGS, GAMT, GBE1, GCH1, GCHFR, GCLM, GNE, GNMT, GPAM, HAL, HSPA5, IDH1, IL22RA2, INPP5K, KMO, LCP1, LPIN2, LYN, MAP3K13, NADK, NAPRT1, NEDD4, PANK1, PIK3R3, PRKAR1B, PSEN2, PSTPIP2, SEC23A, SLC2A2, SPTBN1, STARD5, TARS, TDO2, TTPA, UNC119, USO1, ZAP70	447	cytosol
GO:0005788	1.144e-03	2.677	11 BCHE, DNAJC3, EDEM3, GLT25D1, H6PD, HSPA5, PDIA3, PDIA5, PDIA6, TOR1A, TOR1B	34	endoplasmic reticulum lumen
GO:0005579	1.256e-03	0.315	4 C5, C8A, C8B, C8G	4	membrane attack complex
GO:0044438	6.285e-03	1.417	7 ABCD3, CROT, FAR1, HMGCR, PEX11G, PEX13, PEX16	18	microbody part
GO:0044439	6.285e-03	1.417	7 ABCD3, CROT, FAR1, HMGCR, PEX11G, PEX13, PEX16	18	peroxisomal part
GO:0005737	6.738e-03	210.3	243 A1CF, AARS, ABCA1, ABCD3, ABHD5, ACO1, ACSL5, ACSM5, AFMID, AGPHD1, AGXT, AHR, AKAP12, AKR1D1, AKT3, ALAS1, ALB, ALDH2, ALDH8A1, ALDH9A1, AMDHD1, AP3M1, ARCN1, ARFGEF2, ARRDC3, ATL2, ATPAF1, B4GALT2, BACH1, BBS2, BCHE, BCKDHB, BPNT1, C12orf72, C13orf15, C14orf1, C16orf70, C1orf116, C2CD2, C5orf33, CAPRIN2, CASP8, CCBL1, CCBL2, CDK14, CDO1, CEPT1, CHUK, CKAP5, CLCN6, CLSTN1, COLEC10, COPB1, COPB2, CPOX, CREB3L3, CROT, CSGALNACT1, CTH, CTNNAL1, CYB5A, CYBB, CYP39A1, CYP7B1, DECR2, DERL1, DERL2, DMGDH, DNAJC3, DNMBP, DPP4, DPYS, DYNC2LI1, EDEM1, EDEM3, EGFR, EHHADH, EIF2AK3, EPB41L3, EPB41L4B, ERN1, ESR1, EVI5, FABP2, FAF2, FAM82A1, FAR1, FASN, FDXR, FGB, FGD6, FGG, FN1, FNDC3A, FPGS, FRMD4B, GAMT, GBE1, GCH1, GCHFR, GCLM, GGPS1, GJB1, GLT25D1, GM2A, GNE, GNMT, GPAM, GPT2, GRPEL2, H6PD, HAL, HAO1, HERPUD1, HIBCH, HMGCR, HNF1A, HNF4A, HRG, HSPA5, IDH1, IFIH1, IFT57, IGF1, IKBKE, IL22RA2, INPP5K, JAG2, KATNB1, KIFAP3, KLHL25, KMO, LATS1, LCLAT1, LCP1, LPGAT1, LPIN2, LYN, LZTS2, MAN2A1, MAP3K13, MARCH5, MAST4, MBIP, ME3, MIA3, MTTP, MUT, NADK, NAPRT1, NDRG4, NEDD4, NPC1, NR5A2, NUFIP2, OGDHL, PAFAH2, PALM, PANK1, PANK3, PARD3, PCBD2, PCYOX1, PDIA3, PDIA5, PDIA6, PDP2, PEMT, PEX11G, PEX13, PEX16, PIK3R3, PLA2G12B, PLAT, PPP1R15B, PPP1R7, PPP2R5A, PRKAR1B, PRKD3, PROX1, PSEN2, PSMA4, PSTPIP2, PYGL, RANBP10, RDX, RGN, RNF43, RRM1, SAR1B, SARDH, SCRN1, SEC16B, SEC23A, SEC24D, SEC63, SEPSECS, SERINC3, SFXN1, SGCB, SGCE, SGSM3, SIRT3, SLC17A8, SLC25A16, SLC25A21, SLC25A40, SLC25A47, SLC2A2, SLC30A7, SLC33A1, SLC35D1, SLC39A6, SLIT3, SNN, SPIRE1, SPTBN1, SSR1, SSR3, STAB2, STARD5, TARS, TAT, TBCEL, TBX3, TDO2, TIRAP, TJAP1, TMEM117, TMEM195, TOR1A, TOR1B, TRIB2, TTLL1, TTPA, TUBE1, UNC119, USO1, UVRAG, WASF3, WLS, YIPF5, ZAP70	2671	cytoplasm
GO:0044429	8.504e-03	15.04	29 ACSL5, ACSM5, AGXT, ALAS1, ALDH2, BCKDHB, CASP8, CPOX, CYB5A, DMGDH, FDXR, GPAM, GRPEL2, HIBCH, KMO, MARCH5, ME3, MUT, OGDHL, PDP2, PEMT, SARDH, SFXN1, SIRT3, SLC25A16, SLC25A21, SLC25A40, SLC25A47, SNN	191	mitochondrial part
GO:0000267	9.360e-03	29.68	48 AARS, ABCA1, ABCB11, ABCC1, ABCC2, ABCG5, ADRA1B, AMBP, AQP8, BCHE, C16orf70, CHUK, CNR2, CSGALNACT1, CYB5A, CYP39A1, CYP7B1, DPP4, DPYS, F10, F2, FGB, FNDC3A, GCHFR, GCLM, GGPS1, H6PD, HAL, INPP5K, JAG2, MAP3K13, PEMT, PEX13, PPP2R5A, PRKAR1B, PSEN2, PSTPIP2, PYGL, SLC17A8, SLC2A2, SLC33A1, SLC7A2, SLIT3, SSR3, TDO2, TOR1A, UNC119, USO1	377	cell fraction
GO:0046581	1.016e-02	0.2362	3 ABCB11, ABCC2, DPP4	3	intercellular canaliculus
GO:0005759	1.064e-02	5.827	15 ACSM5, AGXT, ALAS1, ALDH2, BCKDHB, DMGDH, FDXR, GRPEL2, HIBCH, ME3, MUT, OGDHL, PDP2, SARDH, SIRT3	74	mitochondrial matrix
GO:0031980	1.064e-02	5.827	15 ACSM5, AGXT, ALAS1, ALDH2, BCKDHB, DMGDH, FDXR, GRPEL2, HIBCH, ME3, MUT, OGDHL, PDP2, SARDH, SIRT3	74	mitochondrial lumen
GO:0012505	1.163e-02	42.36	63 ACSL5, ARCN1, ARFGEF2, ATL2, B4GALT2, BCHE, C14orf1, C16orf70, CEPT1, CLSTN1, COPB1, COPB2, CREB3L3, CSGALNACT1, CYB5A, CYP39A1, CYP7B1, DERL1, DERL2, DNAJC3, EDEM1, EGFR, EIF2AK3, ERN1, FNDC3A, GCHFR, GJB1, HERPUD1, HMGCR, HSPA5, LCLAT1, LPGAT1, LPIN2, MAN2A1, MARCH5, MIA3, NPC1, NUP93, OIT3, PARD3, PEMT, PEX16, PIP5K1B, PSEN2, RNF34, RNF43, SAR1B, SCRN1, SEC16B, SEC23A, SEC24D, SEC63, SLC17A8, SLC2A9, SLC33A1, SLC35D1, SSR1, SSR3, SUN1, TOR1A, USO1, WLS, YIPF5	538	endomembrane system
GO:0005778	1.243e-02	1.181	6 ABCD3, FAR1, HMGCR, PEX11G, PEX13, PEX16	15	peroxisomal membrane
GO:0031093	1.243e-02	1.181	6 ALB, FGB, FGG, FN1, HRG, IGF1	15	platelet alpha granule lumen
GO:0031903	1.243e-02	1.181	6 ABCD3, FAR1, HMGCR, PEX11G, PEX13, PEX16	15	microbody membrane
GO:0031983	1.711e-02	1.26	6 ALB, FGB, FGG, FN1, HRG, IGF1	16	vesicle lumen
GO:0060205	1.711e-02	1.26	6 ALB, FGB, FGG, FN1, HRG, IGF1	16	cytoplasmic membrane-bounded vesicle lumen
GO:0030120	3.005e-02	1.417	6 ARCN1, COPB1, COPB2, EGFR, SEC23A, SEC24D	18	vesicle coat
GO:0030176	3.022e-02	1.89	7 DERL1, DERL2, EDEM1, ERN1, HSPA5, SLC35D1, SSR3	24	integral to endoplasmic reticulum membrane
GO:0031091	3.791e-02	1.496	6 ALB, FGB, FGG, FN1, HRG, IGF1	19	platelet alpha granule
GO:0031090	4.322e-02	53.07	72 ABCD3, ACSL5, ARCN1, ARFGEF2, ATL2, B4GALT2, C14orf1, C16orf70, CASP8, CEPT1, CLCN6, CLSTN1, COPB1, COPB2, CREB3L3, CSGALNACT1, CYB5A, CYP39A1, CYP7B1, DERL1, DERL2, DNAJC3, EDEM1, EGFR, EIF2AK3, ERN1, FAR1, FNDC3A, GCHFR, GJB1, GPAM, GRPEL2, HERPUD1, HMGCR, HSPA5, IKBKE, KMO, LCLAT1, LPGAT1, LPIN2, MAN2A1, MARCH5, MIA3, NPC1, PEMT, PEX11G, PEX13, PEX16, PSEN2, RNF43, SAR1B, SCRN1, SEC16B, SEC23A, SEC24D, SEC63, SFXN1, SLC17A8, SLC25A16, SLC25A21, SLC25A40, SLC25A47, SLC33A1, SLC35D1, SNN, SSR1, SSR3, SUN1, TOR1A, USO1, WLS, YIPF5	674	organelle membrane

Id	Pvalue	ExpCount	Count	Size	Term
GO:0048037	6.457e-08	6.505	27 ACBD5, AGXT, ALAS1, ALB, ALDH9A1, CCBL1, CCBL2, CTH, CYBB, DMGDH, EHHADH, FASN, GPT2, H6PD, HAO1, HMGCR, IDH1, KMO, ME3, MOCOS, OGDHL, PAH, PYGL, SARDH, SIRT3, TAT, TGDS	83	cofactor binding
GO:0019842	6.038e-06	4.311	19 AGXT, ALAS1, ALB, C8G, CCBL1, CCBL2, CTH, DMGDH, FASN, GNMT, GPT2, MOCOS, MUT, OGDHL, PYGL, RBP4, SLC19A2, TAT, TTPA	55	vitamin binding
GO:0016491	1.262e-05	16.07	40 AKR1D1, ALDH2, ALDH8A1, ALDH9A1, BCKDHB, BCMO1, CDO1, CPOX, CYB5A, CYBB, CYBRD1, CYP39A1, CYP7B1, DECR2, DMGDH, EHHADH, FAR1, FASN, FDXR, FRRS1, GCLM, H6PD, HAO1, HGD, HMGCR, IDH1, IYD, KMO, ME3, OGDHL, PAH, PCBD2, PCYOX1, PDIA5, RRM1, SARDH, SDR42E1, STAB2, TDO2, TMEM195	205	oxidoreductase activity
GO:0031406	6.483e-05	4.154	17 ACBD5, AGXT, ALB, DMGDH, DPYS, FABP2, FASN, GCHFR, GNMT, HNF4A, NEDD4, NR1H4, PAH, PYGL, SLC19A2, TAT, TDO2	53	carboxylic acid binding
GO:0016597	1.813e-04	1.959	11 AGXT, DMGDH, DPYS, FASN, GCHFR, GNMT, NEDD4, PAH, SLC19A2, TAT, TDO2	25	amino acid binding
GO:0030170	2.195e-04	1.646	10 AGXT, ALAS1, ALB, CCBL1, CCBL2, CTH, GPT2, MOCOS, PYGL, TAT	21	pyridoxal phosphate binding
GO:0070279	2.195e-04	1.646	10 AGXT, ALAS1, ALB, CCBL1, CCBL2, CTH, GPT2, MOCOS, PYGL, TAT	21	vitamin B6 binding
GO:0043176	1.465e-03	3.37	13 AGXT, ALDH9A1, BCHE, DMGDH, DPYS, FASN, GCHFR, GNMT, NEDD4, PAH, SLC19A2, TAT, TDO2	43	amine binding
GO:0050662	2.714e-03	4.624	15 ACBD5, ALDH9A1, CYBB, DMGDH, EHHADH, H6PD, HAO1, HMGCR, IDH1, KMO, ME3, OGDHL, SARDH, SIRT3, TGDS	59	coenzyme binding
GO:0003824	2.734e-03	140.3	177 A1CF, A2LD1, AARS, ABCA1, ABCA12, ABCB11, ABCC1, ABCC2, ABCD3, ABCG5, ABHD5, ACO1, ACSL5, ACSM5, AFMID, AGPHD1, AGXT, AKR1D1, AKT3, ALAS1, ALDH2, ALDH8A1, ALDH9A1, AMDHD1, ASPG, ATL2, B4GALT2, BCHE, BCKDHB, BCMO1, BPNT1, C11orf54, C12orf72, C5orf33, CASP8, CCBL1, CCBL2, CDK14, CDO1, CEPT1, CHUK, CPB2, CPE, CPOX, CROT, CSGALNACT1, CTH, CYB5A, CYBB, CYBRD1, CYP39A1, CYP7B1, DAK, DECR2, DIP2A, DMGDH, DNTT, DPP4, DPYS, DYNC2LI1, EDEM1, EDEM3, EGFR, EHHADH, EIF2AK3, ERN1, F10, F2, F9, FAR1, FASN, FDXR, FPGS, FRRS1, GAMT, GBE1, GCH1, GCLM, GGPS1, GLT25D1, GM2A, GNAI1, GNB5, GNE, GNMT, GPAM, GPLD1, GPT2, H6PD, HABP2, HAL, HAO1, HELB, HGD, HIBCH, HMGCR, HTRA1, IDH1, IFIH1, IKBKE, INPP5B, INPP5K, IYD, KATNB1, KLB, KMO, LATS1, LCLAT1, LCMT1, LIPC, LPGAT1, LPIN2, LYN, MAN2A1, MAP3K13, MARCH5, MASP2, MAST4, MAT1A, ME3, MOCOS, MOCS1, MUT, MYO1B, NADK, NAPRT1, NEDD4, OGDHL, PAFAH2, PAH, PANK1, PANK3, PAPSS2, PARP16, PCBD2, PCYOX1, PDE6D, PDIA3, PDIA5, PDIA6, PDP2, PEMT, PIK3R3, PIP5K1B, PLA2G12B, PLAT, PLK3, PM20D1, PPP1R15B, PRKD3, PROZ, PSEN2, PSMA4, PYGL, RNF34, RNF43, RRM1, SARDH, SCRN1, SDR42E1, SEPSECS, SIRT3, SLC26A5, SMARCA1, STAB2, TARS, TAT, TDO2, TGDS, TMEM195, TOR1A, TOR1B, TRIB2, TTLL1, TUBE1, ZAP70, ZDHHC6	1790	catalytic activity
GO:0016616	3.602e-03	1.881	9 AKR1D1, CYB5A, EHHADH, FASN, H6PD, HMGCR, IDH1, ME3, SDR42E1	24	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016614	4.214e-03	2.351	10 AKR1D1, CYB5A, EHHADH, FASN, H6PD, HAO1, HMGCR, IDH1, ME3, SDR42E1	30	oxidoreductase activity, acting on CH-OH group of donors
GO:0016769	1.276e-02	1.019	6 AGXT, ALAS1, CCBL1, CCBL2, GPT2, TAT	13	transferase activity, transferring nitrogenous groups
GO:0016903	1.276e-02	1.019	6 ALDH2, ALDH8A1, ALDH9A1, BCKDHB, FAR1, OGDHL	13	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0004497	1.349e-02	1.411	7 CYP39A1, CYP7B1, FRRS1, KMO, PAH, PCBD2, TMEM195	18	monooxygenase activity
GO:0008483	1.446e-02	0.7054	5 AGXT, CCBL1, CCBL2, GPT2, TAT	9	transaminase activity
GO:0004252	1.559e-02	2.821	10 DPP4, F10, F2, F9, HABP2, HTRA1, MASP2, PLAT, PROZ, TOR1A	36	serine-type endopeptidase activity
GO:0004879	2.505e-02	2.038	8 AHR, ESR1, HNF4A, NR0B2, NR1H3, NR1H4, NR5A2, RXRA	26	ligand-dependent nuclear receptor activity
GO:0033293	2.567e-02	1.176	6 ACBD5, ALB, FABP2, HNF4A, NR1H4, PYGL	15	monocarboxylic acid binding
GO:0004866	3.474e-02	2.665	9 AMBP, C5, FETUB, HRG, HSPA5, SERPINA10, SERPINC1, SPINK4, SPP2	34	endopeptidase inhibitor activity
GO:0046906	3.802e-02	1.724	7 AMBP, CYB5A, CYBB, CYP39A1, CYP7B1, MUT, TDO2	22	tetrapyrrole binding
GO:0016829	4.016e-02	5.016	13 ACO1, BCKDHB, CCBL1, CCBL2, CTH, DAK, EHHADH, FASN, HAL, MOCOS, PCBD2, TAT, TGDS	64	lyase activity
GO:0061135	4.055e-02	2.743	9 AMBP, C5, FETUB, HRG, HSPA5, SERPINA10, SERPINC1, SPINK4, SPP2	35	endopeptidase regulator activity
GO:0008236	4.114e-02	3.292	10 DPP4, F10, F2, F9, HABP2, HTRA1, MASP2, PLAT, PROZ, TOR1A	42	serine-type peptidase activity
GO:0017171	4.114e-02	3.292	10 DPP4, F10, F2, F9, HABP2, HTRA1, MASP2, PLAT, PROZ, TOR1A	42	serine hydrolase activity
GO:0046983	4.278e-02	16.14	29 ABCG5, AGXT, ALDH9A1, AMBP, BACH1, CCBL1, CCBL2, CHUK, CPOX, CREB3L3, CYBB, DPP4, EGFR, GCH1, GCLM, GRPEL2, HNF1A, HNF4A, IDH1, IL12B, INHBA, KATNB1, MAP3K13, NR0B2, PAH, PRLR, PYGL, RXRA, TARS	206	protein dimerization activity
GO:0030414	4.711e-02	2.821	9 AMBP, C5, FETUB, HRG, HSPA5, SERPINA10, SERPINC1, SPINK4, SPP2	36	peptidase inhibitor activity

Id	Pvalue	ExpCount	Count	Size	Term
04610	6.756e-06	2.343	13 C5, C8A, C8B, C8G, CPB2, F10, F2, F9, FGB, FGG, MASP2, PLAT, SERPINC1	21	Complement and coagulation cascades
01100	3.454e-04	39.39	65 ACO1, ACSL5, ACSM5, AFMID, AGXT, AKR1D1, ALAS1, ALDH2, ALDH9A1, AMDHD1, B4GALT2, BCKDHB, BCMO1, BPNT1, CDO1, CEPT1, CPOX, CSGALNACT1, CTH, DAK, DMGDH, DPYS, EHHADH, FASN, FPGS, GAMT, GBE1, GCH1, GCLM, GGPS1, GNE, GPAM, GPT2, H6PD, HAL, HAO1, HGD, HIBCH, HMGCR, IDH1, INPP5B, INPP5K, KMO, LCLAT1, LIPC, MAN2A1, MAT1A, ME3, MUT, NADK, OGDHL, PAFAH2, PAH, PANK1, PANK3, PAPSS2, PEMT, PIP5K1B, PLA2G12B, RRM1, SARDH, SLC33A1, TAT, TDO2, TGDS	353	Metabolic pathways
04146	3.034e-03	3.347	12 ABCD3, ACSL5, AGXT, CROT, DECR2, EHHADH, FAR1, HAO1, IDH1, PEX11G, PEX13, PEX16	30	Peroxisome
04141	7.875e-03	6.583	17 DERL1, DERL2, DNAJC3, EDEM1, EDEM3, EIF2AK3, ERN1, HERPUD1, HSPA5, PDIA3, PDIA6, SAR1B, SEC23A, SEC24D, SEC63, SSR1, SSR3	59	Protein processing in endoplasmic reticulum
00260	1.084e-02	1.451	7 AGXT, ALAS1, CTH, DMGDH, GAMT, GNMT, SARDH	13	Glycine, serine and threonine metabolism
02010	1.719e-02	1.562	7 ABCA1, ABCA12, ABCB11, ABCC1, ABCC2, ABCD3, ABCG5	14	ABC transporters
04950	2.915e-02	0.8926	5 HNF1A, HNF4A, NR5A2, ONECUT1, SLC2A2	8	Maturity onset diabetes of the young
00380	3.520e-02	1.785	7 AFMID, ALDH2, ALDH9A1, EHHADH, KMO, OGDHL, TDO2	16	Tryptophan metabolism
00120	4.692e-02	0.3347	3 AKR1D1, CYP39A1, CYP7B1	3	Primary bile acid biosynthesis
00410	4.788e-02	1.004	5 ALDH2, ALDH9A1, DPYS, EHHADH, HIBCH	9	beta-Alanine metabolism

No enriched terms

No enriched terms

Entrez genes

A1CFAPOBEC1 complementation factor (ENSG00000148584), score: 0.56 A2LD1AIG2-like domain 1 (ENSG00000134864), score: 0.45 AARSalanyl-tRNA synthetase (ENSG00000090861), score: 0.45 ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (ENSG00000165029), score: 0.54 ABCA12ATP-binding cassette, sub-family A (ABC1), member 12 (ENSG00000144452), score: 0.58 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.7 ABCC1ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (ENSG00000103222), score: -0.53 ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ENSG00000023839), score: 0.59 ABCD3ATP-binding cassette, sub-family D (ALD), member 3 (ENSG00000117528), score: 0.64 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.62 ABHD5abhydrolase domain containing 5 (ENSG00000011198), score: 0.49 ACBD5acyl-CoA binding domain containing 5 (ENSG00000107897), score: 0.62 ACO1aconitase 1, soluble (ENSG00000122729), score: 0.49 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.59 ACSM5acyl-CoA synthetase medium-chain family member 5 (ENSG00000183549), score: 0.44 ADRA1Badrenergic, alpha-1B-, receptor (ENSG00000170214), score: 0.53 AFMIDarylformamidase (ENSG00000183077), score: 0.47 AGPHD1aminoglycoside phosphotransferase domain containing 1 (ENSG00000188266), score: 0.42 AGXTalanine-glyoxylate aminotransferase (ENSG00000172482), score: 0.49 AHRaryl hydrocarbon receptor (ENSG00000106546), score: 0.49 AKAP12A kinase (PRKA) anchor protein 12 (ENSG00000131016), score: -0.52 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.49 AKT3v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (ENSG00000117020), score: -0.5 ALAS1aminolevulinate, delta-, synthase 1 (ENSG00000023330), score: 0.52 ALBalbumin (ENSG00000163631), score: 0.6 ALDH2aldehyde dehydrogenase 2 family (mitochondrial) (ENSG00000111275), score: 0.47 ALDH8A1aldehyde dehydrogenase 8 family, member A1 (ENSG00000118514), score: 0.48 ALDH9A1aldehyde dehydrogenase 9 family, member A1 (ENSG00000143149), score: 0.56 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.54 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.59 AMMECR1LAMME chromosomal region gene 1-like (ENSG00000144233), score: 0.45 AP3M1adaptor-related protein complex 3, mu 1 subunit (ENSG00000185009), score: 0.62 AQP8aquaporin 8 (ENSG00000103375), score: 0.51 ARCN1archain 1 (ENSG00000095139), score: 0.56 ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) (ENSG00000124198), score: 0.42 ARHGAP42Rho GTPase activating protein 42 (ENSG00000165895), score: 0.44 ARRDC3arrestin domain containing 3 (ENSG00000113369), score: 0.49 ASPGasparaginase homolog (S. cerevisiae) (ENSG00000166183), score: 0.5 ATL2atlastin GTPase 2 (ENSG00000119787), score: 0.63 ATPAF1ATP synthase mitochondrial F1 complex assembly factor 1 (ENSG00000123472), score: -0.54 B4GALT2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (ENSG00000117411), score: -0.57 BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 1 (ENSG00000156273), score: 0.55 BBS2Bardet-Biedl syndrome 2 (ENSG00000125124), score: -0.66 BCHEbutyrylcholinesterase (ENSG00000114200), score: 0.43 BCKDHBbranched chain keto acid dehydrogenase E1, beta polypeptide (ENSG00000083123), score: 0.43 BCMO1beta-carotene 15,15'-monooxygenase 1 (ENSG00000135697), score: 0.56 BMP5bone morphogenetic protein 5 (ENSG00000112175), score: 0.44 BPNT13'(2'), 5'-bisphosphate nucleotidase 1 (ENSG00000162813), score: 0.56 C11orf54chromosome 11 open reading frame 54 (ENSG00000182919), score: 0.47 C12orf72chromosome 12 open reading frame 72 (ENSG00000139160), score: 0.47 C13orf15chromosome 13 open reading frame 15 (ENSG00000102760), score: -0.65 C14orf1chromosome 14 open reading frame 1 (ENSG00000133935), score: 0.46 C14orf179chromosome 14 open reading frame 179 (ENSG00000119650), score: -0.57 C16orf70chromosome 16 open reading frame 70 (ENSG00000125149), score: 0.44 C19orf12chromosome 19 open reading frame 12 (ENSG00000131943), score: 0.43 C1orf116chromosome 1 open reading frame 116 (ENSG00000182795), score: 0.49 C2CD2C2 calcium-dependent domain containing 2 (ENSG00000157617), score: 0.46 C5complement component 5 (ENSG00000106804), score: 0.58 C5orf33chromosome 5 open reading frame 33 (ENSG00000152620), score: 0.58 C6orf106chromosome 6 open reading frame 106 (ENSG00000196821), score: 0.45 C7orf23chromosome 7 open reading frame 23 (ENSG00000135185), score: 0.6 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.59 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.59 C8Gcomplement component 8, gamma polypeptide (ENSG00000176919), score: 0.56 C9orf150chromosome 9 open reading frame 150 (ENSG00000153714), score: 0.51 CACNB2calcium channel, voltage-dependent, beta 2 subunit (ENSG00000165995), score: -0.49 CAPRIN2caprin family member 2 (ENSG00000110888), score: -0.54 CASP8caspase 8, apoptosis-related cysteine peptidase (ENSG00000064012), score: 0.49 CBX7chromobox homolog 7 (ENSG00000100307), score: -0.56 CCBL1cysteine conjugate-beta lyase, cytoplasmic (ENSG00000171097), score: 0.47 CCBL2cysteine conjugate-beta lyase 2 (ENSG00000137944), score: 0.62 CCDC92coiled-coil domain containing 92 (ENSG00000119242), score: -0.69 CCRL1chemokine (C-C motif) receptor-like 1 (ENSG00000129048), score: 0.63 CDK14cyclin-dependent kinase 14 (ENSG00000058091), score: -0.54 CDO1cysteine dioxygenase, type I (ENSG00000129596), score: 0.54 CEPT1choline/ethanolamine phosphotransferase 1 (ENSG00000134255), score: 0.54 CHUKconserved helix-loop-helix ubiquitous kinase (ENSG00000213341), score: 0.57 CIB3calcium and integrin binding family member 3 (ENSG00000141977), score: 0.78 CKAP5cytoskeleton associated protein 5 (ENSG00000175216), score: -0.6 CLCN6chloride channel 6 (ENSG00000011021), score: -0.49 CLSTN1calsyntenin 1 (ENSG00000171603), score: -0.57 CNR2cannabinoid receptor 2 (macrophage) (ENSG00000188822), score: 0.77 COLEC10collectin sub-family member 10 (C-type lectin) (ENSG00000184374), score: 0.43 COPB1coatomer protein complex, subunit beta 1 (ENSG00000129083), score: 0.42 COPB2coatomer protein complex, subunit beta 2 (beta prime) (ENSG00000184432), score: 0.45 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.58 CPEcarboxypeptidase E (ENSG00000109472), score: -0.56 CPOXcoproporphyrinogen oxidase (ENSG00000080819), score: 0.62 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.6 CROTcarnitine O-octanoyltransferase (ENSG00000005469), score: 0.62 CRYGNcrystallin, gamma N (ENSG00000127377), score: 0.52 CSGALNACT1chondroitin sulfate N-acetylgalactosaminyltransferase 1 (ENSG00000147408), score: -0.5 CTHcystathionase (cystathionine gamma-lyase) (ENSG00000116761), score: 0.51 CTNNAL1catenin (cadherin-associated protein), alpha-like 1 (ENSG00000119326), score: -0.5 CYB5Acytochrome b5 type A (microsomal) (ENSG00000166347), score: 0.46 CYBBcytochrome b-245, beta polypeptide (ENSG00000165168), score: 0.5 CYBRD1cytochrome b reductase 1 (ENSG00000071967), score: -0.51 CYP39A1cytochrome P450, family 39, subfamily A, polypeptide 1 (ENSG00000146233), score: 0.57 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.79 DAKdihydroxyacetone kinase 2 homolog (S. cerevisiae) (ENSG00000149476), score: 0.51 DECR22,4-dienoyl CoA reductase 2, peroxisomal (ENSG00000242612), score: 0.43 DEPDC6DEP domain containing 6 (ENSG00000155792), score: 0.55 DERL1Der1-like domain family, member 1 (ENSG00000136986), score: 0.49 DERL2Der1-like domain family, member 2 (ENSG00000072849), score: 0.51 DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila) (ENSG00000160305), score: -0.5 DMGDHdimethylglycine dehydrogenase (ENSG00000132837), score: 0.5 DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22 (ENSG00000178401), score: 0.59 DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 3 (ENSG00000102580), score: 0.64 DNMBPdynamin binding protein (ENSG00000107554), score: 0.48 DNTTdeoxynucleotidyltransferase, terminal (ENSG00000107447), score: 0.61 DPP4dipeptidyl-peptidase 4 (ENSG00000197635), score: 0.42 DPYSdihydropyrimidinase (ENSG00000147647), score: 0.44 DYNC2LI1dynein, cytoplasmic 2, light intermediate chain 1 (ENSG00000138036), score: -0.64 EDEM1ER degradation enhancer, mannosidase alpha-like 1 (ENSG00000134109), score: 0.6 EDEM3ER degradation enhancer, mannosidase alpha-like 3 (ENSG00000116406), score: 0.44 EGFRepidermal growth factor receptor (ENSG00000146648), score: 0.67 EHHADHenoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (ENSG00000113790), score: 0.47 EIF2AK3eukaryotic translation initiation factor 2-alpha kinase 3 (ENSG00000172071), score: 0.43 ELK4ELK4, ETS-domain protein (SRF accessory protein 1) (ENSG00000158711), score: 0.63 EPB41L3erythrocyte membrane protein band 4.1-like 3 (ENSG00000082397), score: -0.6 EPB41L4Berythrocyte membrane protein band 4.1 like 4B (ENSG00000095203), score: 0.46 ERN1endoplasmic reticulum to nucleus signaling 1 (ENSG00000178607), score: 0.65 ESR1estrogen receptor 1 (ENSG00000091831), score: 0.52 EVI5ecotropic viral integration site 5 (ENSG00000067208), score: 0.58 F10coagulation factor X (ENSG00000126218), score: 0.62 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.57 F9coagulation factor IX (ENSG00000101981), score: 0.58 FABP2fatty acid binding protein 2, intestinal (ENSG00000145384), score: 1 FAF2Fas associated factor family member 2 (ENSG00000113194), score: 0.41 FAM160B1family with sequence similarity 160, member B1 (ENSG00000151553), score: 0.52 FAM164Afamily with sequence similarity 164, member A (ENSG00000104427), score: -0.51 FAM20Afamily with sequence similarity 20, member A (ENSG00000108950), score: 0.48 FAM69Bfamily with sequence similarity 69, member B (ENSG00000165716), score: -0.58 FAM82A1family with sequence similarity 82, member A1 (ENSG00000115841), score: 0.53 FAR1fatty acyl CoA reductase 1 (ENSG00000197601), score: -0.55 FASNfatty acid synthase (ENSG00000169710), score: 0.5 FDXRferredoxin reductase (ENSG00000161513), score: 0.48 FETUBfetuin B (ENSG00000090512), score: 0.66 FGBfibrinogen beta chain (ENSG00000171564), score: 0.55 FGD6FYVE, RhoGEF and PH domain containing 6 (ENSG00000180263), score: 0.44 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.55 FN1fibronectin 1 (ENSG00000115414), score: 0.44 FNDC3Afibronectin type III domain containing 3A (ENSG00000102531), score: 0.43 FPGSfolylpolyglutamate synthase (ENSG00000136877), score: 0.42 FRMD4BFERM domain containing 4B (ENSG00000114541), score: 0.48 FRRS1ferric-chelate reductase 1 (ENSG00000156869), score: 0.46 GAMTguanidinoacetate N-methyltransferase (ENSG00000130005), score: 0.42 GBE1glucan (1,4-alpha-), branching enzyme 1 (ENSG00000114480), score: 0.44 GCH1GTP cyclohydrolase 1 (ENSG00000131979), score: 0.55 GCHFRGTP cyclohydrolase I feedback regulator (ENSG00000137880), score: 0.42 GCLMglutamate-cysteine ligase, modifier subunit (ENSG00000023909), score: 0.44 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.42 GFRA1GDNF family receptor alpha 1 (ENSG00000151892), score: 0.47 GGPS1geranylgeranyl diphosphate synthase 1 (ENSG00000152904), score: -0.49 GJB1gap junction protein, beta 1, 32kDa (ENSG00000169562), score: 0.5 GLT25D1glycosyltransferase 25 domain containing 1 (ENSG00000130309), score: 0.43 GM2AGM2 ganglioside activator (ENSG00000196743), score: 0.67 GNAI1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (ENSG00000127955), score: -0.66 GNB5guanine nucleotide binding protein (G protein), beta 5 (ENSG00000069966), score: -0.49 GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (ENSG00000159921), score: 0.65 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.61 GPAMglycerol-3-phosphate acyltransferase, mitochondrial (ENSG00000119927), score: 0.42 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.63 GPR146G protein-coupled receptor 146 (ENSG00000164849), score: 0.5 GPT2glutamic pyruvate transaminase (alanine aminotransferase) 2 (ENSG00000166123), score: 0.64 GRPEL2GrpE-like 2, mitochondrial (E. coli) (ENSG00000164284), score: 0.48 H1FXH1 histone family, member X (ENSG00000184897), score: -0.62 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (ENSG00000049239), score: 0.6 HABP2hyaluronan binding protein 2 (ENSG00000148702), score: 0.46 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.72 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.57 HDGFRP3hepatoma-derived growth factor, related protein 3 (ENSG00000166503), score: -0.52 HELBhelicase (DNA) B (ENSG00000127311), score: 0.48 HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (ENSG00000051108), score: 0.61 HGDhomogentisate 1,2-dioxygenase (ENSG00000113924), score: 0.48 HIBCH3-hydroxyisobutyryl-CoA hydrolase (ENSG00000198130), score: 0.47 HMGCR3-hydroxy-3-methylglutaryl-CoA reductase (ENSG00000113161), score: 0.51 HNF1AHNF1 homeobox A (ENSG00000135100), score: 0.44 HNF4Ahepatocyte nuclear factor 4, alpha (ENSG00000101076), score: 0.47 HPXhemopexin (ENSG00000110169), score: 0.58 HRGhistidine-rich glycoprotein (ENSG00000113905), score: 0.54 HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (ENSG00000044574), score: 0.59 HTRA1HtrA serine peptidase 1 (ENSG00000166033), score: -0.52 ICOSinducible T-cell co-stimulator (ENSG00000163600), score: 0.68 IDH1isocitrate dehydrogenase 1 (NADP+), soluble (ENSG00000138413), score: 0.5 IFFO1intermediate filament family orphan 1 (ENSG00000010295), score: -0.52 IFIH1interferon induced with helicase C domain 1 (ENSG00000115267), score: 0.46 IFT57intraflagellar transport 57 homolog (Chlamydomonas) (ENSG00000114446), score: -0.58 IGF1insulin-like growth factor 1 (somatomedin C) (ENSG00000017427), score: 0.57 IGSF6immunoglobulin superfamily, member 6 (ENSG00000140749), score: 0.49 IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (ENSG00000143466), score: 0.59 IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (ENSG00000113302), score: 0.63 IL1RAPinterleukin 1 receptor accessory protein (ENSG00000196083), score: 0.78 IL22RA2interleukin 22 receptor, alpha 2 (ENSG00000164485), score: 0.77 INHBAinhibin, beta A (ENSG00000122641), score: 0.5 INPP5Binositol polyphosphate-5-phosphatase, 75kDa (ENSG00000204084), score: 0.46 INPP5Kinositol polyphosphate-5-phosphatase K (ENSG00000132376), score: -0.49 IRF8interferon regulatory factor 8 (ENSG00000140968), score: 0.53 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.57 JAG2jagged 2 (ENSG00000184916), score: -0.55 JAM3junctional adhesion molecule 3 (ENSG00000166086), score: -0.68 KATNB1katanin p80 (WD repeat containing) subunit B 1 (ENSG00000140854), score: -0.56 KIFAP3kinesin-associated protein 3 (ENSG00000075945), score: -0.5 KLBklotho beta (ENSG00000134962), score: 0.66 KLF15Kruppel-like factor 15 (ENSG00000163884), score: 0.43 KLHL25kelch-like 25 (Drosophila) (ENSG00000183655), score: 0.47 KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (ENSG00000117009), score: 0.51 LARP4BLa ribonucleoprotein domain family, member 4B (ENSG00000107929), score: 0.48 LATS1LATS, large tumor suppressor, homolog 1 (Drosophila) (ENSG00000131023), score: 0.45 LCLAT1lysocardiolipin acyltransferase 1 (ENSG00000172954), score: 0.5 LCMT1leucine carboxyl methyltransferase 1 (ENSG00000205629), score: -0.58 LCP1lymphocyte cytosolic protein 1 (L-plastin) (ENSG00000136167), score: 0.52 LEAP2liver expressed antimicrobial peptide 2 (ENSG00000164406), score: 0.48 LHX8LIM homeobox 8 (ENSG00000162624), score: 0.6 LIFRleukemia inhibitory factor receptor alpha (ENSG00000113594), score: 0.46 LIPClipase, hepatic (ENSG00000166035), score: 0.51 LPGAT1lysophosphatidylglycerol acyltransferase 1 (ENSG00000123684), score: 0.63 LPIN2lipin 2 (ENSG00000101577), score: 0.45 LRIT2leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 (ENSG00000204033), score: 0.54 LRP11low density lipoprotein receptor-related protein 11 (ENSG00000120256), score: -0.5 LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog (ENSG00000147507), score: 0.44 LYSMD3LysM, putative peptidoglycan-binding, domain containing 3 (ENSG00000176018), score: 0.55 LZTS2leucine zipper, putative tumor suppressor 2 (ENSG00000107816), score: -0.55 MAN2A1mannosidase, alpha, class 2A, member 1 (ENSG00000112893), score: 0.54 MAP3K13mitogen-activated protein kinase kinase kinase 13 (ENSG00000073803), score: 0.43 MARCH5membrane-associated ring finger (C3HC4) 5 (ENSG00000198060), score: 0.42 MARVELD2MARVEL domain containing 2 (ENSG00000152939), score: 0.44 MASP2mannan-binding lectin serine peptidase 2 (ENSG00000009724), score: 0.44 MAST4microtubule associated serine/threonine kinase family member 4 (ENSG00000069020), score: -0.55 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.63 MBIPMAP3K12 binding inhibitory protein 1 (ENSG00000151332), score: -0.54 MCM10minichromosome maintenance complex component 10 (ENSG00000065328), score: 0.59 ME3malic enzyme 3, NADP(+)-dependent, mitochondrial (ENSG00000151376), score: -0.63 MIA3melanoma inhibitory activity family, member 3 (ENSG00000154305), score: 0.68 MOCOSmolybdenum cofactor sulfurase (ENSG00000075643), score: 0.54 MOCS1molybdenum cofactor synthesis 1 (ENSG00000124615), score: 0.43 MTSS1Lmetastasis suppressor 1-like (ENSG00000132613), score: -0.53 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.58 MUTmethylmalonyl CoA mutase (ENSG00000146085), score: 0.42 MYO1Bmyosin IB (ENSG00000128641), score: 0.47 NADKNAD kinase (ENSG00000008130), score: 0.44 NAPRT1nicotinate phosphoribosyltransferase domain containing 1 (ENSG00000147813), score: 0.41 NDRG4NDRG family member 4 (ENSG00000103034), score: -0.5 NEDD4neural precursor cell expressed, developmentally down-regulated 4 (ENSG00000069869), score: 0.44 NPC1Niemann-Pick disease, type C1 (ENSG00000141458), score: 0.42 NR0B2nuclear receptor subfamily 0, group B, member 2 (ENSG00000131910), score: 0.44 NR1H3nuclear receptor subfamily 1, group H, member 3 (ENSG00000025434), score: 0.44 NR1H4nuclear receptor subfamily 1, group H, member 4 (ENSG00000012504), score: 0.5 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.66 NUFIP2nuclear fragile X mental retardation protein interacting protein 2 (ENSG00000108256), score: 0.44 NUP93nucleoporin 93kDa (ENSG00000102900), score: -0.55 OBFC1oligonucleotide/oligosaccharide-binding fold containing 1 (ENSG00000107960), score: -0.5 OGDHLoxoglutarate dehydrogenase-like (ENSG00000197444), score: -0.53 OIT3oncoprotein induced transcript 3 (ENSG00000138315), score: 0.45 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.63 ORC2Lorigin recognition complex, subunit 2-like (yeast) (ENSG00000115942), score: -0.5 OSGIN2oxidative stress induced growth inhibitor family member 2 (ENSG00000164823), score: -0.62 PAFAH2platelet-activating factor acetylhydrolase 2, 40kDa (ENSG00000158006), score: 0.54 PAHphenylalanine hydroxylase (ENSG00000171759), score: 0.53 PALMparalemmin (ENSG00000099864), score: -0.49 PANK1pantothenate kinase 1 (ENSG00000152782), score: 0.6 PANK3pantothenate kinase 3 (ENSG00000120137), score: 0.43 PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2 (ENSG00000198682), score: 0.57 PAQR9progestin and adipoQ receptor family member IX (ENSG00000188582), score: 0.48 PARD3par-3 partitioning defective 3 homolog (C. elegans) (ENSG00000148498), score: 0.5 PARP16poly (ADP-ribose) polymerase family, member 16 (ENSG00000138617), score: 0.42 PATZ1POZ (BTB) and AT hook containing zinc finger 1 (ENSG00000100105), score: -0.61 PCBD2pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 (ENSG00000132570), score: 0.5 PCGF2polycomb group ring finger 2 (ENSG00000056661), score: -0.57 PCYOX1prenylcysteine oxidase 1 (ENSG00000116005), score: 0.49 PDE6Dphosphodiesterase 6D, cGMP-specific, rod, delta (ENSG00000156973), score: -0.71 PDIA3protein disulfide isomerase family A, member 3 (ENSG00000167004), score: 0.46 PDIA5protein disulfide isomerase family A, member 5 (ENSG00000065485), score: 0.43 PDIA6protein disulfide isomerase family A, member 6 (ENSG00000143870), score: 0.5 PDP2pyruvate dehyrogenase phosphatase catalytic subunit 2 (ENSG00000172840), score: 0.48 PEMTphosphatidylethanolamine N-methyltransferase (ENSG00000133027), score: 0.5 PEX11Gperoxisomal biogenesis factor 11 gamma (ENSG00000104883), score: 0.42 PEX13peroxisomal biogenesis factor 13 (ENSG00000162928), score: 0.42 PEX16peroxisomal biogenesis factor 16 (ENSG00000121680), score: 0.53 PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma) (ENSG00000117461), score: -0.53 PIP5K1Bphosphatidylinositol-4-phosphate 5-kinase, type I, beta (ENSG00000107242), score: -0.5 PLA2G12Bphospholipase A2, group XIIB (ENSG00000138308), score: 0.52 PLATplasminogen activator, tissue (ENSG00000104368), score: -0.49 PLK3polo-like kinase 3 (ENSG00000173846), score: 0.54 PLXDC2plexin domain containing 2 (ENSG00000120594), score: -0.5 PM20D1peptidase M20 domain containing 1 (ENSG00000162877), score: 0.5 PPP1R15Bprotein phosphatase 1, regulatory (inhibitor) subunit 15B (ENSG00000158615), score: 0.66 PPP1R7protein phosphatase 1, regulatory (inhibitor) subunit 7 (ENSG00000115685), score: -0.52 PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha (ENSG00000066027), score: 0.52 PRKAR1Bprotein kinase, cAMP-dependent, regulatory, type I, beta (ENSG00000188191), score: -0.52 PRKD3protein kinase D3 (ENSG00000115825), score: 0.56 PRLRprolactin receptor (ENSG00000113494), score: 0.44 PROX1prospero homeobox 1 (ENSG00000117707), score: 0.44 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.53 PSEN2presenilin 2 (Alzheimer disease 4) (ENSG00000143801), score: 0.43 PSMA4proteasome (prosome, macropain) subunit, alpha type, 4 (ENSG00000041357), score: 0.46 PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 (ENSG00000173692), score: 0.56 PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (ENSG00000197170), score: 0.46 PSTPIP2proline-serine-threonine phosphatase interacting protein 2 (ENSG00000152229), score: 0.43 PYGLphosphorylase, glycogen, liver (ENSG00000100504), score: 0.57 RANBP10RAN binding protein 10 (ENSG00000141084), score: 0.47 RBP4retinol binding protein 4, plasma (ENSG00000138207), score: 0.42 RDXradixin (ENSG00000137710), score: 0.5 RGNregucalcin (senescence marker protein-30) (ENSG00000130988), score: 0.55 RNF34ring finger protein 34 (ENSG00000170633), score: -0.55 RNF43ring finger protein 43 (ENSG00000108375), score: 0.46 RRM1ribonucleotide reductase M1 (ENSG00000167325), score: -0.53 RXRAretinoid X receptor, alpha (ENSG00000186350), score: 0.51 SAR1BSAR1 homolog B (S. cerevisiae) (ENSG00000152700), score: 0.56 SARDHsarcosine dehydrogenase (ENSG00000123453), score: 0.59 SCRN1secernin 1 (ENSG00000136193), score: -0.49 SDR42E1short chain dehydrogenase/reductase family 42E, member 1 (ENSG00000184860), score: 0.73 SEBOXSEBOX homeobox (ENSG00000109072), score: 0.53 SEC16BSEC16 homolog B (S. cerevisiae) (ENSG00000120341), score: 0.5 SEC23ASec23 homolog A (S. cerevisiae) (ENSG00000100934), score: 0.45 SEC24DSEC24 family, member D (S. cerevisiae) (ENSG00000150961), score: 0.46 SEC63SEC63 homolog (S. cerevisiae) (ENSG00000025796), score: 0.51 SEPSECSSep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (ENSG00000109618), score: 0.53 SERINC3serine incorporator 3 (ENSG00000132824), score: 0.42 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.56 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.57 SFXN1sideroflexin 1 (ENSG00000164466), score: 0.42 SGCBsarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (ENSG00000163069), score: -0.53 SGCEsarcoglycan, epsilon (ENSG00000127990), score: -0.56 SGSM3small G protein signaling modulator 3 (ENSG00000100359), score: -0.51 SIRT3sirtuin 3 (ENSG00000142082), score: 0.49 SLC16A10solute carrier family 16, member 10 (aromatic amino acid transporter) (ENSG00000112394), score: 0.62 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.49 SLC17A8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 (ENSG00000179520), score: 0.74 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (ENSG00000117479), score: 0.58 SLC24A6solute carrier family 24 (sodium/potassium/calcium exchanger), member 6 (ENSG00000089060), score: 0.61 SLC25A16solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 (ENSG00000122912), score: 0.45 SLC25A21solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21 (ENSG00000183032), score: 0.43 SLC25A40solute carrier family 25, member 40 (ENSG00000075303), score: -0.56 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.52 SLC26A5solute carrier family 26, member 5 (prestin) (ENSG00000170615), score: 0.51 SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2 (ENSG00000163581), score: 0.54 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.58 SLC30A10solute carrier family 30, member 10 (ENSG00000196660), score: 0.42 SLC30A7solute carrier family 30 (zinc transporter), member 7 (ENSG00000162695), score: 0.53 SLC31A1solute carrier family 31 (copper transporters), member 1 (ENSG00000136868), score: 0.47 SLC33A1solute carrier family 33 (acetyl-CoA transporter), member 1 (ENSG00000169359), score: 0.55 SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (ENSG00000116704), score: 0.62 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.7 SLC39A6solute carrier family 39 (zinc transporter), member 6 (ENSG00000141424), score: -0.69 SLC39A8solute carrier family 39 (zinc transporter), member 8 (ENSG00000138821), score: 0.42 SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (ENSG00000003989), score: 0.47 SLC7A6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (ENSG00000103064), score: -0.59 SLCO2B1solute carrier organic anion transporter family, member 2B1 (ENSG00000137491), score: 0.55 SLIT3slit homolog 3 (Drosophila) (ENSG00000184347), score: -0.67 SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (ENSG00000102038), score: -0.51 SNNstannin (ENSG00000184602), score: -0.49 SPINK4serine peptidase inhibitor, Kazal type 4 (ENSG00000122711), score: 0.65 SPIRE1spire homolog 1 (Drosophila) (ENSG00000134278), score: -0.58 SPON1spondin 1, extracellular matrix protein (ENSG00000152268), score: -0.52 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.66 SPTBN1spectrin, beta, non-erythrocytic 1 (ENSG00000115306), score: -0.5 SSR1signal sequence receptor, alpha (ENSG00000124783), score: 0.54 SSR3signal sequence receptor, gamma (translocon-associated protein gamma) (ENSG00000114850), score: 0.43 STAB2stabilin 2 (ENSG00000136011), score: 0.43 STARD5StAR-related lipid transfer (START) domain containing 5 (ENSG00000172345), score: 0.46 STOML3stomatin (EPB72)-like 3 (ENSG00000133115), score: 0.48 SUN1Sad1 and UNC84 domain containing 1 (ENSG00000164828), score: -0.56 TAPT1transmembrane anterior posterior transformation 1 (ENSG00000169762), score: 0.6 TARSthreonyl-tRNA synthetase (ENSG00000113407), score: 0.52 TATtyrosine aminotransferase (ENSG00000198650), score: 0.64 TBCCD1TBCC domain containing 1 (ENSG00000113838), score: 0.44 TBCELtubulin folding cofactor E-like (ENSG00000154114), score: 0.59 TBX3T-box 3 (ENSG00000135111), score: 0.43 TCF7transcription factor 7 (T-cell specific, HMG-box) (ENSG00000081059), score: 0.44 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.65 TGDSTDP-glucose 4,6-dehydratase (ENSG00000088451), score: 0.46 TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein (ENSG00000150455), score: 0.46 TJAP1tight junction associated protein 1 (peripheral) (ENSG00000137221), score: -0.55 TLCD1TLC domain containing 1 (ENSG00000160606), score: 0.48 TM2D2TM2 domain containing 2 (ENSG00000169490), score: 0.46 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.68 TM7SF4transmembrane 7 superfamily member 4 (ENSG00000164935), score: 0.46 TMEM106Btransmembrane protein 106B (ENSG00000106460), score: 0.5 TMEM117transmembrane protein 117 (ENSG00000139173), score: -0.49 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.56 TMEM195transmembrane protein 195 (ENSG00000187546), score: 0.78 TOR1Atorsin family 1, member A (torsin A) (ENSG00000136827), score: 0.54 TOR1Btorsin family 1, member B (torsin B) (ENSG00000136816), score: 0.46 TRIB2tribbles homolog 2 (Drosophila) (ENSG00000071575), score: -0.53 TRPA1transient receptor potential cation channel, subfamily A, member 1 (ENSG00000104321), score: 0.44 TSPAN3tetraspanin 3 (ENSG00000140391), score: -0.74 TSR1TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) (ENSG00000167721), score: 0.45 TTC36tetratricopeptide repeat domain 36 (ENSG00000172425), score: 0.51 TTLL1tubulin tyrosine ligase-like family, member 1 (ENSG00000100271), score: -0.56 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.7 TUBE1tubulin, epsilon 1 (ENSG00000074935), score: -0.5 UNC119unc-119 homolog (C. elegans) (ENSG00000109103), score: -0.51 USO1USO1 vesicle docking protein homolog (yeast) (ENSG00000138768), score: 0.51 UVRAGUV radiation resistance associated gene (ENSG00000198382), score: 0.51 VSIG4V-set and immunoglobulin domain containing 4 (ENSG00000155659), score: 0.45 WASF3WAS protein family, member 3 (ENSG00000132970), score: -0.5 WDFY2WD repeat and FYVE domain containing 2 (ENSG00000139668), score: 0.48 WDR36WD repeat domain 36 (ENSG00000134987), score: 0.42 WLSwntless homolog (Drosophila) (ENSG00000116729), score: -0.52 WRBtryptophan rich basic protein (ENSG00000182093), score: -0.49 XCR1chemokine (C motif) receptor 1 (ENSG00000173578), score: 0.47 XKR9XK, Kell blood group complex subunit-related family, member 9 (ENSG00000221947), score: 0.49 YIPF5Yip1 domain family, member 5 (ENSG00000145817), score: 0.42 ZAP70zeta-chain (TCR) associated protein kinase 70kDa (ENSG00000115085), score: 0.54 ZC3H7Azinc finger CCCH-type containing 7A (ENSG00000122299), score: 0.53 ZDHHC6zinc finger, DHHC-type containing 6 (ENSG00000023041), score: 0.59 ZNF462zinc finger protein 462 (ENSG00000148143), score: -0.61 ZNF750zinc finger protein 750 (ENSG00000141579), score: 0.72 ZNF827zinc finger protein 827 (ENSG00000151612), score: -0.49

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
gga_lv_f_ca1	gga	lv	f	_
gga_lv_m_ca1	gga	lv	m	_
mmu_lv_m1_ca1	mmu	lv	m	1
mmu_lv_f_ca1	mmu	lv	f	_
mmu_lv_m2_ca1	mmu	lv	m	2