http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&feed=atom&action=history
Hypergenes Study - Revision history
2024-03-29T01:06:53Z
Revision history for this page on the wiki
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http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=3337&oldid=prev
WikiSysop at 15:19, 20 August 2012
2012-08-20T15:19:20Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 15:19, 20 August 2012</td>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Bulletins]]</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><newstitle> Novel hypertension susceptibility locus in the promoter region of eNOS</newstitle></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><newstitle> Novel hypertension susceptibility locus in the promoter region of eNOS</newstitle></div></td></tr>
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WikiSysop
http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=3334&oldid=prev
WikiSysop at 15:18, 20 August 2012
2012-08-20T15:18:09Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 15:18, 20 August 2012</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><newstitle> Novel hypertension susceptibility locus in the promoter region of eNOS</newstitle></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><newstitle> Novel hypertension susceptibility locus in the promoter region of eNOS</newstitle></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>   </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>   </div></td></tr>
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WikiSysop
http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=3330&oldid=prev
WikiSysop at 15:15, 20 August 2012
2012-08-20T15:15:44Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 15:15, 20 August 2012</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>   </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>   </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><teaser></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><teaser></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>A genome-wide association study by the HYPERGENES Consortium unravelled a novel hypertension susceptibility locus in the promoter region of the eNOS gene and essential hypertension. The article appeared online in <a href="http://hyper.ahajournals.org/content/early/2011/12/19/HYPERTENSIONAHA.111.181990.abstract?sid=8239fe92-5f2a-467e-9bc7-8790f71787f6">Hypertension</a> on 19 December <del class="diffchange diffchange-inline">2012</del>.</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>A genome-wide association study by the HYPERGENES Consortium unravelled a novel hypertension susceptibility locus in the promoter region of the eNOS gene and essential hypertension. The article appeared online in <a href="http://hyper.ahajournals.org/content/early/2011/12/19/HYPERTENSIONAHA.111.181990.abstract?sid=8239fe92-5f2a-467e-9bc7-8790f71787f6">Hypertension</a> on 19 December <ins class="diffchange diffchange-inline">2011</ins>.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     <date>21 December 2011 — 11:30</date></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     <date>21 December 2011 — 11:30</date></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></teaser></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></teaser></div></td></tr>
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WikiSysop
http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=3329&oldid=prev
WikiSysop at 15:15, 20 August 2012
2012-08-20T15:15:29Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 15:15, 20 August 2012</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><teaser></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><teaser></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>A genome-wide association study by the HYPERGENES Consortium unravelled a novel hypertension susceptibility locus in the promoter region of the eNOS gene and essential hypertension. The article appeared online in <a href="http://hyper.ahajournals.org/content/early/2011/12/19/HYPERTENSIONAHA.111.181990.abstract?sid=8239fe92-5f2a-467e-9bc7-8790f71787f6">Hypertension</a> on 19 December <del class="diffchange diffchange-inline">2011</del>.</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>A genome-wide association study by the HYPERGENES Consortium unravelled a novel hypertension susceptibility locus in the promoter region of the eNOS gene and essential hypertension. The article appeared online in <a href="http://hyper.ahajournals.org/content/early/2011/12/19/HYPERTENSIONAHA.111.181990.abstract?sid=8239fe92-5f2a-467e-9bc7-8790f71787f6">Hypertension</a> on 19 December <ins class="diffchange diffchange-inline">2012</ins>.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     <date>21 December 2011 — 11:30</date></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     <date>21 December 2011 — 11:30</date></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></teaser></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></teaser></div></td></tr>
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WikiSysop
http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=3316&oldid=prev
WikiSysop at 15:05, 20 August 2012
2012-08-20T15:05:44Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 15:05, 20 August 2012</td>
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<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Bulletins]]</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><newstitle> Novel hypertension susceptibility locus in the promoter region of eNOS</newstitle></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><newstitle> Novel hypertension susceptibility locus in the promoter region of eNOS</newstitle></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>   </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>   </div></td></tr>
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WikiSysop
http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=3302&oldid=prev
WikiSysop at 14:46, 20 August 2012
2012-08-20T14:46:54Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 14:46, 20 August 2012</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><newstitle> Novel hypertension susceptibility locus in the promoter region of eNOS</newstitle></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><newstitle> Novel hypertension susceptibility locus in the promoter region of eNOS</newstitle></div></td></tr>
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WikiSysop
http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=3301&oldid=prev
WikiSysop at 14:46, 20 August 2012
2012-08-20T14:46:37Z
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 14:46, 20 August 2012</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>   </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>   </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><teaser></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><teaser></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>A genome-wide association study by the HYPERGENES Consortium unravelled a novel hypertension susceptibility locus in the promoter region of the eNOS gene and essential hypertension. The article appeared online in <del class="diffchange diffchange-inline">[</del>http://hyper.ahajournals.org/content/early/2011/12/19/HYPERTENSIONAHA.111.181990.abstract?sid=8239fe92-5f2a-467e-9bc7-8790f71787f6 Hypertension<del class="diffchange diffchange-inline">] </del>on 19 December 2011.</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>A genome-wide association study by the HYPERGENES Consortium unravelled a novel hypertension susceptibility locus in the promoter region of the eNOS gene and essential hypertension. The article appeared online in <ins class="diffchange diffchange-inline"><a href="</ins>http://hyper.ahajournals.org/content/early/2011/12/19/HYPERTENSIONAHA.111.181990.abstract?sid=8239fe92-5f2a-467e-9bc7-8790f71787f6<ins class="diffchange diffchange-inline">"></ins>Hypertension<ins class="diffchange diffchange-inline"></a> </ins>on 19 December 2011.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     <date>21 December 2011 — 11:30</date></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     <date>21 December 2011 — 11:30</date></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></teaser></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></teaser></div></td></tr>
</table>
WikiSysop
http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=2533&oldid=prev
Zoltan at 10:28, 21 December 2011
2011-12-21T10:28:07Z
<p></p>
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 10:28, 21 December 2011</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><teaser></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><teaser></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>A genome-wide association study by the HYPERGENES Consortium unravelled a novel hypertension susceptibility locus in the promoter region of the eNOS gene and essential hypertension. The article <del class="diffchange diffchange-inline">was published </del>in [http://hyper.ahajournals.org/content/early/2011/12/19/HYPERTENSIONAHA.111.181990.abstract?sid=8239fe92-5f2a-467e-9bc7-8790f71787f6 Hypertension] on 19 December 2011.</div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>A genome-wide association study by the HYPERGENES Consortium unravelled a novel hypertension susceptibility locus in the promoter region of the eNOS gene and essential hypertension. The article <ins class="diffchange diffchange-inline">appeared online </ins>in [http://hyper.ahajournals.org/content/early/2011/12/19/HYPERTENSIONAHA.111.181990.abstract?sid=8239fe92-5f2a-467e-9bc7-8790f71787f6 Hypertension] on 19 December 2011.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     <date>21 December 2011 — 11:30</date></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     <date>21 December 2011 — 11:30</date></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></teaser></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></teaser></div></td></tr>
</table>
Zoltan
http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=2532&oldid=prev
Zoltan at 10:27, 21 December 2011
2011-12-21T10:27:27Z
<p></p>
<table class="diff diff-contentalign-left" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #222; text-align: center;">Revision as of 10:27, 21 December 2011</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Bulletins]]  </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Bulletins]]  </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><newstitle> <del class="diffchange diffchange-inline">Mirror extreme BMI phenotypes associated with</del></div></td><td class='diff-marker'>+</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><newstitle> <ins class="diffchange diffchange-inline">Novel hypertension susceptibility locus in </ins>the <ins class="diffchange diffchange-inline">promoter region of eNOS</ins></newstitle></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #222; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">gene dosage at </del>the <del class="diffchange diffchange-inline">chromosome 16p11.2 locus</del></newstitle></div></td><td colspan="2"> </td></tr>
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</table>
Zoltan
http://www2.unil.ch/cbg/index.php?title=Hypergenes_Study&diff=2531&oldid=prev
Zoltan at 10:26, 21 December 2011
2011-12-21T10:26:09Z
<p></p>
<p><b>New page</b></p><div>[[Category:Bulletins]] <br />
<newstitle> Mirror extreme BMI phenotypes associated with<br />
gene dosage at the chromosome 16p11.2 locus</newstitle><br />
<br />
<teaser><br />
A genome-wide association study by the HYPERGENES Consortium unravelled a novel hypertension susceptibility locus in the promoter region of the eNOS gene and essential hypertension. The article was published in [http://hyper.ahajournals.org/content/early/2011/12/19/HYPERTENSIONAHA.111.181990.abstract?sid=8239fe92-5f2a-467e-9bc7-8790f71787f6 Hypertension] on 19 December 2011.<br />
<date>21 December 2011 — 11:30</date><br />
</teaser><br />
<br />
The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases and controls from extensively characterized cohorts recruited over many years in different European regions. The discovery phase consisted of 1,865 cases and 1,750 controls genotyped with 1M Illumina array. Best hits were followed up in a validation panel of 1,385 cases and 1,246 controls that were genotyped with a custom array of 14,055 markers. We identified a new hypertension susceptibility locus (rs3918226) in the promoter region of the endothelial NO synthase gene (odds ratio: 1.54 [95% CI: 1.37–1.73]; combined P=2.58E-13). A meta-analysis, using other in silico/de novo genotyping data for a total of 21,714 subjects, resulted in an overall odds ratio of 1.34 (95% CI: 1.25–1.44; P=1.03E-14). The quantitative analysis on a population-based sample revealed an effect size of 1.91 (95% CI: 0.16–3.66) for systolic and 1.40 (95% CI: 0.25–2.55) for diastolic blood pressure. We identified in silico a potential binding site for ETS transcription factors directly next to rs3918226, suggesting a potential modulation of endothelial NO synthase expression. Biological evidence links endothelial NO synthase with hypertension, because it is a critical mediator of cardiovascular homeostasis and blood pressure control via vascular tone regulation.<br />
<br />
<pubmed><br />
22184326<br />
</pubmed></div>
Zoltan