Comments for Tutorial Genomics, Ecology, Evolution, etc

Comment on Convergent evolution of the genomes of marine mammals by s

Mon, 29 Mar 2021 15:28:06 +0000

sorry for my english . i have an interesting argument about the existence of god and evolution: say that we will see a self replicating robot ( lets say even with dna) on a far planet. do we need to conclude design or a natural process in this case? remember that according to evolution if its made from organic components and have a self replicating system we need to conclude a natural process because it has living traits. ]]>

Comment on ExAC presents a catalogue of human protein-coding genetic variation by tonicmovies

Tue, 12 Nov 2019 19:20:39 +0000

Separately, Walsh and colleagues from Imperial College London and the University of Oxford, U.K., have demonstrated the utility of the amassed genetic information for evaluating genes involved in multigenic heritable diseases. The team compared ExAC data to 7,855 clinical cardiomyopathy cases, finding that many putative cardiomyopathy-linked genes are unlikely to contribute to the disease. By focusing on confirmed genes, we expect this study to improve the clinical genetic testing of cardiomyopathies by reducing the number of uncertain and even false positive results, wrote Walsh. The team s results appeared in ]]>

Comment on Genomic analyses inform on migration events during the peopling of Eurasia by Marc Robinson-Rechavi

Mon, 13 Nov 2017 08:21:36 +0000

In reply to meran.

Sure, please share.

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Comment on Genomic analyses inform on migration events during the peopling of Eurasia by meran

Thu, 02 Nov 2017 01:48:48 +0000

Nice article. It can be a literature for student. May I share this? ]]>

Comment on The African Genome Variation Project shapes medical genetics in Africa. by Meshack

Thu, 19 Jan 2017 18:35:27 +0000

Sorry I meant does it mean that the Sotho and Zulu in South Africa have the same DNA as the Igbo population in Nigeria ]]>

Comment on The African Genome Variation Project shapes medical genetics in Africa. by Meshack

Thu, 19 Jan 2017 18:33:25 +0000

Please clarify this for me does it mean the Sotho and Zulu in South Africa have the same as the Igbo population in Nigeria?

Thanks

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Comment on Rapid Evolution of Enormous, Multichromosomal Genomes in Flowering Plant Mitochondria with Exceptionally High Mutation Rates by ousmanecis

Mon, 11 Jun 2012 08:13:47 +0000

Indeed, assembly of such template containing thousand of mitochondrial genomes may be challenging. Repeat regions are particularly difficult to assemble, and there is a risk to collapse repeat regions. However, such “errors” would decrease the assembly size. The presence of multiples copies of mitochondrial genomes can theoretically detect by an extremely high coverage compared to the nuclear genome. But, because the nuclear genome is not yet available, it was not possible to perform such comparison. Evidences of mitochondrial genome expansion provided by the authors in Silene conica and Silene noctiflora are quite convincing, as compared to other members within the genus. I agree that many of the mitochondrial chromosomes lacks intact genes, which may indicates that genes undergoes duplication followed by degeneration – as you suggested -. Nevertheless, the genome expansion is not correlated with the gene content. As shown in table 1, the gene repertoire in fast evolving species, do not exhibit significant degeneration. Here, the vast majority of the genome is composed by noncoding regions without significant contribution of a particular type of repeat. ]]>

Comment on Rapid Evolution of Enormous, Multichromosomal Genomes in Flowering Plant Mitochondria with Exceptionally High Mutation Rates by Peter

Wed, 06 Jun 2012 21:50:09 +0000

Mitochondrial genomes are odd though: there are ~20 copies per mitochondrion, and 1000-2000 mitochondria per cell.One can envisage a situation where some mitochondria have a mutation inactivating gene A, while others have a mutation inactivating gene B: now you have to maintain both of these populations within the cell. Depending on the dynamics of mutation rate, mitochondrial genome replication, recombination and gene conversion, these (initially identical) copies could subsequently diverge from each other.Rinse and repeat – with a high mutation rate – and you end up with a large population of mitochondrial chromosomes, each retaining only a small number of functional genes, with the remainder of each circle degenerated into random rubbish.Is that really “genome expansion” in the same way you’d talk about changes in nuclear genome size? I guess it’s related, in that one mechanism for nuclear genome expansion is by duplication of a genome segment followed by degeneration or neofunctionalisation of the duplicated genes – but in the mitochondrial case, the “duplication” is inherent in the fact that you started with thousands of copies per cell!There may be an interesting analogy to be drawn with the proliferation of repeats on Y chromosomes as they degenerate. ]]>

Comment on Tutorials on whole exome sequencing by Jérôme Goudet

Wed, 09 Nov 2011 22:39:55 +0000

Cool, thanks Marc!If interested in exome sequencing, here is another discussion thread :The-Beginning-of-the-End-for-Exome-Sequencingalso commented in NGS Linkedin discussion group:death-exome-sequencing ]]>