Under-expression is coded with green,
over-expression with red color.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
eye development
The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.
embryonic epithelial tube formation
The morphogenesis of an embryonic epithelium into a tube-shaped structure.
neural tube formation
The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
morphogenesis of an epithelium
The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
transcription
The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA.
transcription, DNA-dependent
The cellular synthesis of RNA on a template of DNA.
regulation of transcription, DNA-dependent
Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription.
regulation of transcription from RNA polymerase II promoter
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
transcription from RNA polymerase II promoter
The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
embryo development
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
nervous system development
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
central nervous system development
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
brain development
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
sensory organ development
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
embryo development ending in birth or egg hatching
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
regulation of biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
gene expression
The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
regulation of gene expression
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
anatomical structure formation involved in morphogenesis
The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
primary neural tube formation
The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.
RNA metabolic process
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
morphogenesis of embryonic epithelium
The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
neural tube development
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
neurogenesis
Generation of cells within the nervous system.
cell differentiation
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
RNA biosynthetic process
The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
tube formation
Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.
tube morphogenesis
The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
tube development
The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
chordate embryonic development
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
camera-type eye development
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
embryonic morphogenesis
The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of nitrogen compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
regulation of RNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
retina development in camera-type eye
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
epithelium development
The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.
epithelial tube morphogenesis
The process by which the anatomical structures of a tube are generated and organized from an epithelium. Morphogenesis pertains to the creation of form. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
epithelial tube formation
The developmental process pertaining to the initial formation of an epithelial tube.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
nucleic acid metabolic process
Any cellular metabolic process involving nucleic acids.
all
NA
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
regulation of nitrogen compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
embryo development
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
anatomical structure formation involved in morphogenesis
The developmental process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
embryonic morphogenesis
The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
tube development
The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of gene expression
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
tube morphogenesis
The process by which the anatomical structures of a tube are generated and organized. Morphogenesis pertains to the creation of form. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
tube formation
Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.
tissue morphogenesis
The process by which the anatomical structures of a tissue are generated and organized. Morphogenesis pertains to the creation of form.
organ morphogenesis
Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
regulation of RNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
transcription
The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
transcription, DNA-dependent
The cellular synthesis of RNA on a template of DNA.
regulation of transcription
Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
RNA biosynthetic process
The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers.
regulation of RNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA.
transcription
The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA.
RNA metabolic process
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
central nervous system development
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
neural tube development
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
neurogenesis
Generation of cells within the nervous system.
brain development
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
epithelial tube formation
The developmental process pertaining to the initial formation of an epithelial tube.
morphogenesis of embryonic epithelium
The process by which the anatomical structures of embryonic epithelia are generated and organized. Morphogenesis pertains to the creation of form.
epithelial tube morphogenesis
The process by which the anatomical structures of a tube are generated and organized from an epithelium. Morphogenesis pertains to the creation of form. Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
neural tube development
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
embryonic epithelial tube formation
The morphogenesis of an embryonic epithelium into a tube-shaped structure.
morphogenesis of an epithelium
The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
regulation of transcription, DNA-dependent
Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription.
regulation of transcription, DNA-dependent
Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription.
neural tube formation
The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
primary neural tube formation
The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube.
regulation of transcription from RNA polymerase II promoter
Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.
retina development in camera-type eye
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
nucleus
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
nucleic acid binding
Interacting selectively and non-covalently with any nucleic acid.
DNA binding
Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).
sequence-specific DNA binding transcription factor activity
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
glutamate receptor activity
Combining with glutamate to initiate a change in cell activity.
sequence-specific DNA binding
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
NA
ACVR2Bactivin A receptor, type IIB (ENSG00000114739), score: 0.63 ANKLE1ankyrin repeat and LEM domain containing 1 (ENSG00000160117), score: 0.79 ANKS6ankyrin repeat and sterile alpha motif domain containing 6 (ENSG00000165138), score: 0.63 ARVCFarmadillo repeat gene deleted in velocardiofacial syndrome (ENSG00000099889), score: 0.63 ATF7activating transcription factor 7 (ENSG00000170653), score: 0.66 B3GALTLbeta 1,3-galactosyltransferase-like (ENSG00000187676), score: -0.65 BACH2BTB and CNC homology 1, basic leucine zipper transcription factor 2 (ENSG00000112182), score: 0.64 BAHCC1BAH domain and coiled-coil containing 1 (ENSG00000171282), score: 0.71 BANK1B-cell scaffold protein with ankyrin repeats 1 (ENSG00000153064), score: 0.75 BARHL1BarH-like homeobox 1 (ENSG00000125492), score: 0.84 BARHL2BarH-like homeobox 2 (ENSG00000143032), score: 0.89 BEST4bestrophin 4 (ENSG00000142959), score: 0.63 BICD1bicaudal D homolog 1 (Drosophila) (ENSG00000151746), score: 0.65 BPTFbromodomain PHD finger transcription factor (ENSG00000171634), score: 0.63 BTN2A1butyrophilin, subfamily 2, member A1 (ENSG00000112763), score: 0.7 C15orf27chromosome 15 open reading frame 27 (ENSG00000169758), score: 0.71 C16orf11chromosome 16 open reading frame 11 (ENSG00000161992), score: 0.76 C1orf127chromosome 1 open reading frame 127 (ENSG00000175262), score: 0.65 C20orf117chromosome 20 open reading frame 117 (ENSG00000149639), score: 0.69 C7orf16chromosome 7 open reading frame 16 (ENSG00000106341), score: 0.68 CBLN1cerebellin 1 precursor (ENSG00000102924), score: 0.78 CBLN3cerebellin 3 precursor (ENSG00000139899), score: 0.78 CCDC109Acoiled-coil domain containing 109A (ENSG00000156026), score: 0.66 CCNJLcyclin J-like (ENSG00000135083), score: 0.68 CDC42BPGCDC42 binding protein kinase gamma (DMPK-like) (ENSG00000171219), score: 0.63 CDH15cadherin 15, type 1, M-cadherin (myotubule) (ENSG00000129910), score: 0.87 CDH7cadherin 7, type 2 (ENSG00000081138), score: 0.72 CDONCdon homolog (mouse) (ENSG00000064309), score: 0.72 CECR2cat eye syndrome chromosome region, candidate 2 (ENSG00000099954), score: 0.68 CELF1CUGBP, Elav-like family member 1 (ENSG00000149187), score: 0.62 CERKLceramide kinase-like (ENSG00000188452), score: 0.69 CHD7chromodomain helicase DNA binding protein 7 (ENSG00000171316), score: 0.77 CHN2chimerin (chimaerin) 2 (ENSG00000106069), score: 0.65 CHRNA3cholinergic receptor, nicotinic, alpha 3 (ENSG00000080644), score: 0.78 CLK4CDC-like kinase 4 (ENSG00000113240), score: 0.69 CNOT2CCR4-NOT transcription complex, subunit 2 (ENSG00000111596), score: 0.64 CNPY1canopy 1 homolog (zebrafish) (ENSG00000146910), score: 0.71 COL13A1collagen, type XIII, alpha 1 (ENSG00000197467), score: 0.87 COL27A1collagen, type XXVII, alpha 1 (ENSG00000196739), score: 0.62 CPLX4complexin 4 (ENSG00000166569), score: 0.8 CRTAMcytotoxic and regulatory T cell molecule (ENSG00000109943), score: 0.91 CTCFCCCTC-binding factor (zinc finger protein) (ENSG00000102974), score: 0.64 DACT1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) (ENSG00000165617), score: 0.64 DCLRE1BDNA cross-link repair 1B (ENSG00000118655), score: 0.73 DGCR8DiGeorge syndrome critical region gene 8 (ENSG00000128191), score: 0.66 DHRS13dehydrogenase/reductase (SDR family) member 13 (ENSG00000167536), score: 0.68 DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha (ENSG00000119772), score: 0.62 DUOX1dual oxidase 1 (ENSG00000137857), score: 0.73 ECE1endothelin converting enzyme 1 (ENSG00000117298), score: -0.66 EN2engrailed homeobox 2 (ENSG00000164778), score: 0.84 EOMESeomesodermin (ENSG00000163508), score: 0.75 EPHB1EPH receptor B1 (ENSG00000154928), score: 0.61 ESPNLespin-like (ENSG00000144488), score: 0.64 ESYT3extended synaptotagmin-like protein 3 (ENSG00000158220), score: 0.69 EXPH5exophilin 5 (ENSG00000110723), score: 0.78 FAT2FAT tumor suppressor homolog 2 (Drosophila) (ENSG00000086570), score: 0.85 FBXO31F-box protein 31 (ENSG00000103264), score: 0.63 FGF17fibroblast growth factor 17 (ENSG00000158815), score: 0.69 FGF3fibroblast growth factor 3 (ENSG00000186895), score: 0.76 FGF5fibroblast growth factor 5 (ENSG00000138675), score: 0.79 FHDC1FH2 domain containing 1 (ENSG00000137460), score: 0.74 FSTL5follistatin-like 5 (ENSG00000168843), score: 0.71 FUT9fucosyltransferase 9 (alpha (1,3) fucosyltransferase) (ENSG00000172461), score: 0.63 FZD7frizzled homolog 7 (Drosophila) (ENSG00000155760), score: 0.72 GIGYF1GRB10 interacting GYF protein 1 (ENSG00000146830), score: 0.64 GLCEglucuronic acid epimerase (ENSG00000138604), score: 0.65 GNG13guanine nucleotide binding protein (G protein), gamma 13 (ENSG00000127588), score: 0.67 GPATCH8G patch domain containing 8 (ENSG00000186566), score: 0.65 GPRIN3GPRIN family member 3 (ENSG00000185477), score: 0.77 GRID2glutamate receptor, ionotropic, delta 2 (ENSG00000152208), score: 0.7 GRID2IPglutamate receptor, ionotropic, delta 2 (Grid2) interacting protein (ENSG00000215045), score: 0.84 GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C (ENSG00000161509), score: 0.7 GRM1glutamate receptor, metabotropic 1 (ENSG00000152822), score: 0.64 GRM4glutamate receptor, metabotropic 4 (ENSG00000124493), score: 0.78 HINFPhistone H4 transcription factor (ENSG00000172273), score: 0.69 IFFO2intermediate filament family orphan 2 (ENSG00000169991), score: 0.72 IGFBP2insulin-like growth factor binding protein 2, 36kDa (ENSG00000115457), score: -0.66 IL16interleukin 16 (lymphocyte chemoattractant factor) (ENSG00000172349), score: 0.74 INCENPinner centromere protein antigens 135/155kDa (ENSG00000149503), score: 0.69 INO80INO80 homolog (S. cerevisiae) (ENSG00000128908), score: 0.64 IP6K2inositol hexakisphosphate kinase 2 (ENSG00000068745), score: 0.66 JMJD1Cjumonji domain containing 1C (ENSG00000171988), score: 0.66 KCNK9potassium channel, subfamily K, member 9 (ENSG00000169427), score: 0.69 KCNRGpotassium channel regulator (ENSG00000198553), score: 0.7 KCTD2potassium channel tetramerisation domain containing 2 (ENSG00000180901), score: 0.61 KDM4Clysine (K)-specific demethylase 4C (ENSG00000107077), score: 0.76 KIAA0182KIAA0182 (ENSG00000131149), score: 0.68 KIAA0802KIAA0802 (ENSG00000168502), score: 0.74 KRT39keratin 39 (ENSG00000196859), score: 0.71 KRT40keratin 40 (ENSG00000204889), score: 0.71 LBX1ladybird homeobox 1 (ENSG00000138136), score: 0.77 LDB2LIM domain binding 2 (ENSG00000169744), score: -0.7 LHX5LIM homeobox 5 (ENSG00000089116), score: 0.74 LOC146429putative solute carrier family 22 member ENSG00000182157 (ENSG00000182157), score: 0.88 LONRF3LON peptidase N-terminal domain and ring finger 3 (ENSG00000175556), score: 0.62 LRCH1leucine-rich repeats and calponin homology (CH) domain containing 1 (ENSG00000136141), score: 0.66 LRRC26leucine rich repeat containing 26 (ENSG00000184709), score: 0.67 MAB21L1mab-21-like 1 (C. elegans) (ENSG00000180660), score: 0.87 MAML1mastermind-like 1 (Drosophila) (ENSG00000161021), score: 0.72 MAML3mastermind-like 3 (Drosophila) (ENSG00000196782), score: 0.76 MAXMYC associated factor X (ENSG00000125952), score: 0.67 MDGA1MAM domain containing glycosylphosphatidylinositol anchor 1 (ENSG00000112139), score: 0.81 MEIS1Meis homeobox 1 (ENSG00000143995), score: 0.67 MID1midline 1 (Opitz/BBB syndrome) (ENSG00000101871), score: 0.62 MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (ENSG00000118058), score: 0.66 MPP3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) (ENSG00000161647), score: 0.62 MRGPRDMAS-related GPR, member D (ENSG00000172938), score: 0.72 MRPL33mitochondrial ribosomal protein L33 (ENSG00000158019), score: -0.67 MYT1myelin transcription factor 1 (ENSG00000196132), score: 0.7 NAB2NGFI-A binding protein 2 (EGR1 binding protein 2) (ENSG00000166886), score: 0.63 NHLH2nescient helix loop helix 2 (ENSG00000177551), score: 0.86 NKAIN1Na+/K+ transporting ATPase interacting 1 (ENSG00000084628), score: 0.72 NKX6-3NK6 homeobox 3 (ENSG00000165066), score: 0.84 NODALnodal homolog (mouse) (ENSG00000156574), score: 0.64 NRG2neuregulin 2 (ENSG00000158458), score: 0.64 NRIP2nuclear receptor interacting protein 2 (ENSG00000053702), score: 0.75 NYNRINNYN domain and retroviral integrase containing (ENSG00000205978), score: 0.67 ODZ1odz, odd Oz/ten-m homolog 1(Drosophila) (ENSG00000009694), score: 0.79 OSBPL2oxysterol binding protein-like 2 (ENSG00000130703), score: 0.65 OTX2orthodenticle homeobox 2 (ENSG00000165588), score: 0.69 PAX6paired box 6 (ENSG00000007372), score: 0.72 PAXIP1PAX interacting (with transcription-activation domain) protein 1 (ENSG00000157212), score: 0.7 PHF2PHD finger protein 2 (ENSG00000197724), score: 0.66 PISDphosphatidylserine decarboxylase (ENSG00000241878), score: 0.73 PKIBprotein kinase (cAMP-dependent, catalytic) inhibitor beta (ENSG00000135549), score: 0.84 PLXND1plexin D1 (ENSG00000004399), score: -0.66 PRDM10PR domain containing 10 (ENSG00000170325), score: 0.74 PRPF6PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) (ENSG00000101161), score: 0.63 PTCH1patched 1 (ENSG00000185920), score: 0.65 PTCHD1patched domain containing 1 (ENSG00000165186), score: 0.75 PWWP2APWWP domain containing 2A (ENSG00000170234), score: 0.71 PYDC1PYD (pyrin domain) containing 1 (ENSG00000169900), score: 0.79 QSOX2quiescin Q6 sulfhydryl oxidase 2 (ENSG00000165661), score: 0.69 RAB37RAB37, member RAS oncogene family (ENSG00000172794), score: 0.66 RCAN3RCAN family member 3 (ENSG00000117602), score: 0.84 REV3LREV3-like, catalytic subunit of DNA polymerase zeta (yeast) (ENSG00000009413), score: 0.67 RFTN1raftlin, lipid raft linker 1 (ENSG00000131378), score: -0.65 RMND5Arequired for meiotic nuclear division 5 homolog A (S. cerevisiae) (ENSG00000153561), score: 0.66 SART3squamous cell carcinoma antigen recognized by T cells 3 (ENSG00000075856), score: 0.68 SCGNsecretagogin, EF-hand calcium binding protein (ENSG00000079689), score: 0.69 SETD5SET domain containing 5 (ENSG00000168137), score: 0.7 SGK223homolog of rat pragma of Rnd2 (ENSG00000182319), score: 0.67 SHBSrc homology 2 domain containing adaptor protein B (ENSG00000107338), score: -0.68 SKIv-ski sarcoma viral oncogene homolog (avian) (ENSG00000157933), score: 0.64 SKOR1SKI family transcriptional corepressor 1 (ENSG00000188779), score: 0.63 SLC35F4solute carrier family 35, member F4 (ENSG00000151812), score: 0.83 SNRKSNF related kinase (ENSG00000163788), score: 0.72 SNX25sorting nexin 25 (ENSG00000109762), score: 0.65 SOCS5suppressor of cytokine signaling 5 (ENSG00000171150), score: 0.64 SP4Sp4 transcription factor (ENSG00000105866), score: 0.69 SPINK6serine peptidase inhibitor, Kazal type 6 (ENSG00000178172), score: 0.85 SPTBN5spectrin, beta, non-erythrocytic 5 (ENSG00000137877), score: 0.69 STACSH3 and cysteine rich domain (ENSG00000144681), score: 0.71 SYT2synaptotagmin II (ENSG00000143858), score: 0.63 TAS2R3taste receptor, type 2, member 3 (ENSG00000127362), score: 0.63 TFAP2Etranscription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon) (ENSG00000116819), score: 0.72 TGM1transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) (ENSG00000092295), score: 0.77 TIAM1T-cell lymphoma invasion and metastasis 1 (ENSG00000156299), score: 0.74 TLL1tolloid-like 1 (ENSG00000038295), score: 0.82 TMC2transmembrane channel-like 2 (ENSG00000149488), score: 0.93 TP73tumor protein p73 (ENSG00000078900), score: 0.81 TRIM11tripartite motif-containing 11 (ENSG00000154370), score: 0.76 TRIM17tripartite motif-containing 17 (ENSG00000162931), score: 0.62 TRIM67tripartite motif-containing 67 (ENSG00000119283), score: 0.83 UBASH3Bubiquitin associated and SH3 domain containing B (ENSG00000154127), score: 0.68 USTuronyl-2-sulfotransferase (ENSG00000111962), score: 0.63 VAX2ventral anterior homeobox 2 (ENSG00000116035), score: 0.64 VSX1visual system homeobox 1 (ENSG00000100987), score: 1 VWA5Avon Willebrand factor A domain containing 5A (ENSG00000110002), score: -0.66 XKR7XK, Kell blood group complex subunit-related family, member 7 (ENSG00000101321), score: 0.78 YTHDF1YTH domain family, member 1 (ENSG00000149658), score: 0.63 ZFPM2zinc finger protein, multitype 2 (ENSG00000169946), score: 0.65 ZIC2Zic family member 2 (odd-paired homolog, Drosophila) (ENSG00000043355), score: 0.74 ZIC4Zic family member 4 (ENSG00000174963), score: 0.85 ZIC5Zic family member 5 (odd-paired homolog, Drosophila) (ENSG00000139800), score: 0.78 ZNF157zinc finger protein 157 (ENSG00000147117), score: 0.66 ZNF238zinc finger protein 238 (ENSG00000179456), score: 0.63 ZNF296zinc finger protein 296 (ENSG00000170684), score: 0.71 ZNF521zinc finger protein 521 (ENSG00000198795), score: 0.77 ZNF671zinc finger protein 671 (ENSG00000083814), score: 0.63
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| ptr_cb_f_ca1 | ptr | cb | f | _ |
| ppa_cb_f_ca1 | ppa | cb | f | _ |
| ggo_cb_f_ca1 | ggo | cb | f | _ |
| hsa_cb_m_ca1 | hsa | cb | m | _ |
| ppa_cb_m_ca1 | ppa | cb | m | _ |
| hsa_cb_f_ca1 | hsa | cb | f | _ |
| ptr_cb_m_ca1 | ptr | cb | m | _ |
