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two-component signal transduction system (phosphorelay)

A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

signal transduction

The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

nucleoside phosphate metabolic process

The chemical reactions and pathways involving any phosphorylated nucleoside.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

potassium ion transport

The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell surface receptor linked signaling pathway

Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

G-protein coupled receptor protein signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

G-protein signaling, coupled to cyclic nucleotide second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate.

activation of phospholipase C activity

The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

serotonin receptor signaling pathway

The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

neurological system process

A organ system process carried out by any of the organs or tissues of neurological system.

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

circadian rhythm

Any biological process in an organism that recurs with a regularity of approximately 24 hours.

feeding behavior

Behavior associated with the intake of food.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

nucleotide metabolic process

The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).

nucleoside monophosphate metabolic process

The chemical reactions and pathways involving a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.

nucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.

nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).

cyclic nucleotide metabolic process

The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.

cyclic nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of phospholipase activity

Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

positive regulation of phospholipase activity

Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

positive regulation of phospholipase C activity

Any process that increases the rate of phospholipase C activity.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

second-messenger-mediated signaling

A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.

cyclic-nucleotide-mediated signaling

A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response.

phosphoinositide-mediated signaling

A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response.

signaling pathway

The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.

intracellular signaling pathway

The series of molecular events whereby information is sent from one location to another within a cell.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

signal transmission

The process whereby a signal is released and/or conveyed from one location to another.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

nucleobase, nucleoside and nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.

intracellular signal transduction

The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

positive regulation of molecular function

Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

rhythmic process

Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of catalytic activity

Any process that modulates the activity of an enzyme.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of hydrolase activity

Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

positive regulation of hydrolase activity

Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.

nucleobase, nucleoside and nucleotide metabolic process

The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.

regulation of lipase activity

Any process that modulates the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

positive regulation of lipase activity

Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of molecular function

Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

small molecule biosynthetic process

The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

signal transduction

The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of catalytic activity

Any process that modulates the activity of an enzyme.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

nucleobase, nucleoside and nucleotide metabolic process

The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.

nucleobase, nucleoside and nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

intracellular signal transduction

The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

positive regulation of catalytic activity

Any process that activates or increases the activity of an enzyme.

nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.

positive regulation of hydrolase activity

Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.

nucleobase, nucleoside and nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides.

positive regulation of lipase activity

Any process that increases the frequency, rate or extent of lipase activity, the hydrolysis of a lipid or phospholipid.

nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).

potassium ion transport

The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

positive regulation of phospholipase activity

Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.

nucleoside monophosphate biosynthetic process

The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.

G-protein signaling, coupled to cyclic nucleotide second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate.

cyclic nucleotide biosynthetic process

The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.

activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

extracellular matrix

A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

potassium channel complex

An ion channel complex through which potassium ions pass.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

synapse

The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.

all

NA

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

peptide receptor activity

Combining with an extracellular or intracellular peptide to initiate a change in cell activity.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

receptor binding

Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

G-protein coupled receptor activity

A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.

neuropeptide Y receptor activity

Combining with neuropeptide Y to initiate a change in cell activity.

serotonin receptor activity

Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity.

hormone activity

The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.

neuropeptide hormone activity

The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

voltage-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.

voltage-gated potassium channel activity

Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

potassium channel activity

Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

drug binding

Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.

neuropeptide receptor activity

Combining with a neuropeptide to initiate a change in cell activity.

G-protein coupled amine receptor activity

A receptor that binds an extracellular amine and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

peptide receptor activity, G-protein coupled

Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

peptide hormone binding

Interacting selectively and non-covalently with any peptide with hormonal activity in animals.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

voltage-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

voltage-gated cation channel activity

Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

neurotransmitter receptor activity

Combining with a neurotransmitter to initiate a change in cell activity.

neurotransmitter binding

Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.

peptide binding

Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.

hormone binding

Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.

neuropeptide binding

Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).

amine binding

Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.

serotonin binding

Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

peptide hormone binding

Interacting selectively and non-covalently with any peptide with hormonal activity in animals.

neuropeptide receptor activity

Combining with a neuropeptide to initiate a change in cell activity.

peptide receptor activity

Combining with an extracellular or intracellular peptide to initiate a change in cell activity.

neurotransmitter receptor activity

Combining with a neurotransmitter to initiate a change in cell activity.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

neuropeptide receptor activity

Combining with a neuropeptide to initiate a change in cell activity.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

peptide receptor activity, G-protein coupled

Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.

voltage-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.

voltage-gated cation channel activity

Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.

voltage-gated potassium channel activity

Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0007268	4.290e-11	4.992	28 ARC, CARTPT, CHRM1, CRH, DLGAP2, EGR3, FRMPD4, GJD2, GLRA3, GRIN2B, HCRTR2, HRH1, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR6, KCNQ3, KCNQ5, NETO1, PDYN, PNOC, SHC3, SLIT1, SST, TACR1, WNT7A	287	synaptic transmission
GO:0007186	3.517e-10	7.236	32 ADRA1D, ATRNL1, CARTPT, CHRM1, CHRM3, DGKB, GABRA4, GPR123, GPR26, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR4, HTR6, MAS1, MC4R, NPY2R, OPRD1, PDYN, PNOC, PRLHR, RGS4, RXFP3, SST, TACR1, TRHR, VIP	416	G-protein coupled receptor protein signaling pathway
GO:0019226	9.336e-10	5.74	28 ARC, CARTPT, CHRM1, CRH, DLGAP2, EGR3, FRMPD4, GJD2, GLRA3, GRIN2B, HCRTR2, HRH1, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR6, KCNQ3, KCNQ5, NETO1, PDYN, PNOC, SHC3, SLIT1, SST, TACR1, WNT7A	330	transmission of nerve impulse
GO:0007267	5.362e-09	9.636	35 ADCYAP1, ADRA1D, ARC, CARTPT, CHRM1, CRH, DLGAP2, EGR3, FGF10, FRMPD4, GJD2, GLRA3, GRIN2B, HCRTR2, HRH1, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR6, KCNQ3, KCNQ5, MC4R, NETO1, PCDH8, PCSK1, PDE8B, PDYN, PNOC, SHC3, SLIT1, SST, TACR1, WNT7A	554	cell-cell signaling
GO:0050877	1.116e-07	12.63	38 ADRA1D, ARC, CARTPT, CHRM1, CRH, CRYGA, DLGAP2, EGR3, FRMPD4, GJD2, GLRA3, GRIN2B, GRPR, HCRTR2, HRH1, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR6, KCNQ3, KCNQ5, MAPK3, NETO1, OPN4, OPRD1, OR10G7, OR2AG2, PDYN, PNOC, RORB, SHC3, SLIT1, SST, TACR1, TSHZ3, WNT7A	726	neurological system process
GO:0006813	3.137e-07	2.052	15 HTR2A, KCNA3, KCNA4, KCNA6, KCNB2, KCNF1, KCNG1, KCNH3, KCNH4, KCNQ3, KCNS1, KCNV1, KCTD16, KCTD4, SLC24A4	118	potassium ion transport
GO:0006811	4.221e-07	11.53	35 ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GLRA3, GRIN2B, HTR2A, HTR2C, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, OPRD1, SLC10A4, SLC13A4, SLC24A4, SLC8A3, TRAPPC10, TRPC5	663	ion transport
GO:0007631	4.604e-06	0.9741	10 CARTPT, CRH, GRIN2B, HCRTR2, HTR1A, HTR1B, HTR2C, MC4R, PRLHR, TACR1	56	feeding behavior
GO:0030001	5.134e-06	7.131	25 CACNG3, CLCA1, GRIN2B, HTR2A, HTR2C, KCNA3, KCNA4, KCNA6, KCNB2, KCNF1, KCNG1, KCNH3, KCNH4, KCNQ3, KCNS1, KCNV1, KCTD16, KCTD4, OPRD1, SLC10A4, SLC13A4, SLC24A4, SLC8A3, TRAPPC10, TRPC5	410	metal ion transport
GO:0007166	6.284e-06	20.94	47 ADCYAP1, ADRA1D, ALK, ATRNL1, CARTPT, CHRM1, CHRM3, DGKB, EPHA5, FGF10, FSHB, GABRA4, GPR123, GPR26, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR4, HTR6, LECT1, MAPK3, MAS1, MC4R, NLK, NPY2R, OPRD1, PDYN, PNOC, PRLHR, PTPRA, RGS4, RXFP3, SHC3, SST, TACR1, TRHR, VIP, WNT1, WNT10B, WNT16, WNT7A	1204	cell surface receptor linked signaling pathway
GO:0015672	9.926e-06	4.418	19 HTR2A, KCNA3, KCNA4, KCNA6, KCNB2, KCNF1, KCNG1, KCNH3, KCNH4, KCNQ3, KCNS1, KCNV1, KCTD16, KCTD4, SLC10A4, SLC13A4, SLC24A4, SLC8A3, TRAPPC10	254	monovalent inorganic cation transport
GO:0003008	1.343e-05	17.36	41 ADRA1D, ARC, CARTPT, CHRM1, CHRM3, CRH, CRYGA, DLGAP2, EGR3, FGF10, FRMPD4, GJD2, GLRA3, GRIN2B, GRPR, HCRTR2, HRH1, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR6, KCNB2, KCNQ3, KCNQ5, MAPK3, NETO1, OPN4, OPRD1, OR10G7, OR2AG2, PDYN, PNOC, RORB, SHC3, SLIT1, SST, TACR1, TSHZ3, WNT7A	998	system process
GO:0019932	4.222e-05	3.514	16 ADRA1D, CHRM1, GPR26, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR4, HTR6, MC4R, NPY2R, OPRD1, RXFP3, TACR1	202	second-messenger-mediated signaling
GO:0023060	5.513e-05	35.08	63 ADRA1D, ARC, CARTPT, CHRM1, CHRM3, CNTNAP5, CRH, DLGAP2, EGR3, FGF10, FIBCD1, FRMPD4, FSHB, GABRQ, GJD2, GLRA3, GPR123, GPR26, GRIN2B, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, KCNH3, KCNH4, KCNQ3, KCNQ5, MAPK3, MAS1, MC4R, NETO1, NLK, NPY2R, NRG3, OPN4, OPRD1, PDE2A, PDE8B, PDYN, PLXNA4, PNOC, PRKG2, RAB3B, RASL10A, RGS4, RXFP3, SHC3, SLC7A3, SLIT1, SPRED3, SST, SYNGAP1, TACR1, UNC5D, WNT16, WNT7A	2017	signal transmission
GO:0023052	5.867e-05	48.65	79 ADCYAP1, ADRA1D, ALK, ARC, ATRNL1, CARTPT, CHRM1, CHRM3, CNTNAP5, CRH, DGKB, DLGAP2, EGR3, EPHA5, FGF10, FIBCD1, FRMPD4, FSHB, GABRA4, GABRQ, GJD2, GLRA3, GPR123, GPR26, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, KCNH3, KCNH4, KCNQ3, KCNQ5, LECT1, MAPK3, MAS1, MC4R, NETO1, NLK, NPY2R, NRG3, OPN4, OPRD1, PCDH8, PCSK1, PDE2A, PDE8B, PDYN, PLXNA4, PNOC, PRKG2, PRLHR, PTPRA, RAB3B, RASL10A, RGS4, RXFP3, SHC3, SLC7A3, SLIT1, SPRED3, SST, SYNGAP1, TACR1, TRHR, UNC5D, VIP, WNT1, WNT10B, WNT16, WNT7A	2797	signaling
GO:0023046	6.066e-05	35.19	63 ADRA1D, ARC, CARTPT, CHRM1, CHRM3, CNTNAP5, CRH, DLGAP2, EGR3, FGF10, FIBCD1, FRMPD4, FSHB, GABRQ, GJD2, GLRA3, GPR123, GPR26, GRIN2B, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, KCNH3, KCNH4, KCNQ3, KCNQ5, MAPK3, MAS1, MC4R, NETO1, NLK, NPY2R, NRG3, OPN4, OPRD1, PDE2A, PDE8B, PDYN, PLXNA4, PNOC, PRKG2, RAB3B, RASL10A, RGS4, RXFP3, SHC3, SLC7A3, SLIT1, SPRED3, SST, SYNGAP1, TACR1, UNC5D, WNT16, WNT7A	2023	signaling process
GO:0006812	6.818e-05	8.314	25 CACNG3, CLCA1, GRIN2B, HTR2A, HTR2C, KCNA3, KCNA4, KCNA6, KCNB2, KCNF1, KCNG1, KCNH3, KCNH4, KCNQ3, KCNS1, KCNV1, KCTD16, KCTD4, OPRD1, SLC10A4, SLC13A4, SLC24A4, SLC8A3, TRAPPC10, TRPC5	478	cation transport
GO:0007154	1.908e-04	23.12	46 ADCYAP1, ADRA1D, ARC, CARTPT, CHRM1, CRH, DLGAP2, EGR3, FGF10, FREM3, FRMPD4, GJD2, GLRA3, GRIN2B, HCRTR2, HRH1, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR6, KCNQ3, KCNQ5, LECT1, MC4R, NETO1, NLK, PCDH8, PCSK1, PDE8B, PDYN, PNOC, RGS4, SHC3, SLC7A3, SLC8A3, SLIT1, SPRED3, SST, SYNGAP1, TACR1, WNT1, WNT10B, WNT16, WNT7A	1329	cell communication
GO:0007187	2.365e-04	1.548	10 ADRA1D, GPR26, HTR1A, HTR1B, HTR1E, HTR4, HTR6, MC4R, NPY2R, OPRD1	89	G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0032501	3.595e-04	57.4	86 ADRA1D, ALK, ARC, BCL11B, CARTPT, CDH4, CHRM1, CHRM3, CNTN3, CRH, CRYGA, DLGAP2, DLX1, DLX2, DSCAM, DSPP, EGR3, ENC1, FGF10, FRMPD4, FSHB, GJD2, GLRA3, GP5, GRIN2B, GRPR, HCRTR2, HOPX, HRH1, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR6, IL1RAPL2, KAL1, KCNB2, KCNQ3, KCNQ5, LECT1, LMO4, LPPR4, MAMLD1, MAPK3, MAS1, MC4R, MEF2C, MEPE, MKL2, MMP16, MYO16, NDEL1, NETO1, NEUROD6, NFATC3, NPY2R, NRG3, OPN4, OPRD1, OR10G7, OR2AG2, OTX1, PCDH8, PCSK1, PDYN, PLXNA4, PNOC, RNF135, RORB, SHC3, SLIT1, SLITRK1, SPRED3, SST, TACR1, TBR1, TRPC5, TSHZ3, UNC5D, VIP, WNT1, WNT10B, WNT16, WNT7A, XYLT1	3300	multicellular organismal process
GO:0007610	7.757e-04	6.714	20 CARTPT, CRH, DSCAM, FGF10, GRIN2B, GRPR, HCRTR2, HTR1A, HTR1B, HTR2A, HTR2C, KAL1, MC4R, NETO1, NPY2R, OPRD1, PRLHR, SHC3, SLIT1, TACR1	386	behavior
GO:0019935	9.288e-04	1.844	10 ADRA1D, GPR26, HTR1A, HTR1B, HTR1E, HTR4, HTR6, MC4R, NPY2R, OPRD1	106	cyclic-nucleotide-mediated signaling
GO:0007200	1.788e-03	0.6262	6 CHRM1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	36	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0007623	2.272e-03	0.9567	7 CARTPT, CRH, EGR3, KCNH7, OPN4, PROKR2, RORB	55	circadian rhythm
GO:0007210	2.590e-03	0.08697	3 HTR1A, HTR2A, HTR2C	5	serotonin receptor signaling pathway
GO:0007399	2.626e-03	16.12	33 ALK, BCL11B, CDH4, CHRM1, CHRM3, CNTN3, DLX1, DLX2, DSCAM, EGR3, ENC1, IL1RAPL2, KAL1, LMO4, LPPR4, MAS1, MEF2C, MYO16, NDEL1, NEUROD6, OTX1, PCSK1, PLXNA4, RORB, SHC3, SLIT1, SLITRK1, TBR1, TRPC5, WNT1, WNT10B, WNT7A, XYLT1	927	nervous system development
GO:0000160	4.586e-03	0.1044	3 KCNH3, KCNH4, PDE8B	6	two-component signal transduction system (phosphorelay)
GO:0009187	6.421e-03	1.966	9 ADCYAP1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1, PDE8B	113	cyclic nucleotide metabolic process
GO:0044057	6.998e-03	4.505	14 ADRA1D, ARC, CARTPT, CHRM3, CRH, FGF10, GRIN2B, HTR1B, HTR2A, KCNB2, NETO1, OPRD1, TACR1, TSHZ3	259	regulation of system process
GO:0007202	7.097e-03	0.8349	6 CHRM1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	48	activation of phospholipase C activity
GO:0010863	7.097e-03	0.8349	6 CHRM1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	48	positive regulation of phospholipase C activity
GO:0035556	8.346e-03	16.59	32 ADRA1D, CARTPT, CHRM1, FGF10, GPR26, GRIN2B, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR4, HTR6, MAPK3, MAS1, MC4R, NLK, NPY2R, NRG3, OPRD1, RAB3B, RASL10A, RGS4, RXFP3, SHC3, SLC7A3, SPRED3, SYNGAP1, TACR1, WNT16	954	intracellular signal transduction
GO:0010518	9.359e-03	0.8871	6 CHRM1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	51	positive regulation of phospholipase activity
GO:0009190	9.372e-03	1.652	8 ADCYAP1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1	95	cyclic nucleotide biosynthetic process
GO:0007409	1.033e-02	3.096	11 BCL11B, CDH4, DSCAM, KAL1, LPPR4, NDEL1, SLIT1, SLITRK1, TBR1, WNT7A, XYLT1	178	axonogenesis
GO:0010517	1.104e-02	0.9219	6 CHRM1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	53	regulation of phospholipase activity
GO:0021882	1.116e-02	0.03479	2 DLX1, DLX2	2	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
GO:0021893	1.116e-02	0.03479	2 DLX1, DLX2	2	cerebral cortex GABAergic interneuron fate commitment
GO:0021898	1.116e-02	0.03479	2 DLX1, DLX2	2	commitment of multipotent stem cells to the neuronal lineage in the forebrain
GO:0007223	1.240e-02	0.3479	4 WNT1, WNT10B, WNT16, WNT7A	20	Wnt receptor signaling pathway, calcium modulating pathway
GO:0060193	1.400e-02	0.9741	6 CHRM1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	56	positive regulation of lipase activity
GO:0050770	1.632e-02	1.009	6 CDH4, DSCAM, NDEL1, SLIT1, WNT7A, XYLT1	58	regulation of axonogenesis
GO:0055085	1.749e-02	10.21	22 KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, OPRD1, SLC13A4, SLC24A4, SLC7A3, SLC8A3, TRPC5	587	transmembrane transport
GO:0019233	1.762e-02	0.6784	5 GRIN2B, HTR2A, MAPK3, OPRD1, TACR1	39	sensory perception of pain
GO:0048667	1.842e-02	3.374	11 BCL11B, CDH4, DSCAM, KAL1, LPPR4, NDEL1, SLIT1, SLITRK1, TBR1, WNT7A, XYLT1	194	cell morphogenesis involved in neuron differentiation
GO:0030817	2.098e-02	1.478	7 ADCYAP1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	85	regulation of cAMP biosynthetic process
GO:0007613	2.107e-02	0.7131	5 CRH, GRIN2B, HTR2A, NETO1, TACR1	41	memory
GO:0009123	2.151e-02	2.418	9 ADCYAP1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1, PDE8B	139	nucleoside monophosphate metabolic process
GO:0006171	2.206e-02	1.496	7 ADCYAP1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	86	cAMP biosynthetic process
GO:0048511	2.237e-02	2.435	9 CARTPT, CRH, EGR3, FSHB, GRIN2B, KCNH7, OPN4, PROKR2, RORB	140	rhythmic process
GO:0048812	2.289e-02	3.496	11 BCL11B, CDH4, DSCAM, KAL1, LPPR4, NDEL1, SLIT1, SLITRK1, TBR1, WNT7A, XYLT1	201	neuron projection morphogenesis
GO:0030814	2.319e-02	1.513	7 ADCYAP1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	87	regulation of cAMP metabolic process
GO:0048015	2.431e-02	1.113	6 CHRM1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	64	phosphoinositide-mediated signaling
GO:0035567	2.461e-02	0.4348	4 WNT1, WNT10B, WNT16, WNT7A	25	non-canonical Wnt receptor signaling pathway
GO:0023033	2.488e-02	35.22	53 ADCYAP1, ADRA1D, ALK, ATRNL1, CARTPT, CHRM1, CHRM3, DGKB, EPHA5, FGF10, FSHB, GABRA4, GPR123, GPR26, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR4, HTR6, LECT1, MAPK3, MAS1, MC4R, NLK, NPY2R, NRG3, OPRD1, PDYN, PNOC, PRLHR, PTPRA, RAB3B, RASL10A, RGS4, RXFP3, SHC3, SLC7A3, SPRED3, SST, SYNGAP1, TACR1, TRHR, VIP, WNT1, WNT10B, WNT16, WNT7A	2025	signaling pathway
GO:0021877	2.550e-02	0.05218	2 DLX1, DLX2	3	forebrain neuron fate commitment
GO:0048715	2.550e-02	0.05218	2 DLX1, DLX2	3	negative regulation of oligodendrocyte differentiation
GO:0060191	2.563e-02	1.131	6 CHRM1, HCRTR2, HRH1, HTR2A, RXFP3, TACR1	65	regulation of lipase activity
GO:0009124	2.610e-02	2.018	8 ADCYAP1, GPR26, HTR1A, HTR1B, HTR2C, MC4R, NPY2R, OPRD1	116	nucleoside monophosphate biosynthetic process
GO:0030802	2.788e-02	1.583	7 ADCYAP1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	91	regulation of cyclic nucleotide biosynthetic process
GO:0030808	2.788e-02	1.583	7 ADCYAP1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	91	regulation of nucleotide biosynthetic process
GO:0048731	2.836e-02	34.65	52 ALK, ARC, BCL11B, CARTPT, CDH4, CHRM1, CHRM3, CNTN3, CRH, CRYGA, DLX1, DLX2, DSCAM, DSPP, EGR3, ENC1, FGF10, FSHB, GRIN2B, IL1RAPL2, KAL1, LECT1, LMO4, LPPR4, MAMLD1, MAPK3, MAS1, MEF2C, MEPE, MKL2, MYO16, NDEL1, NEUROD6, NFATC3, NPY2R, NRG3, OTX1, PCDH8, PCSK1, PLXNA4, RORB, SHC3, SLIT1, SLITRK1, TBR1, TRPC5, TSHZ3, WNT1, WNT10B, WNT16, WNT7A, XYLT1	1992	system development
GO:0050768	2.852e-02	0.7827	5 DLX1, DLX2, SLIT1, WNT7A, XYLT1	45	negative regulation of neurogenesis
GO:0007188	2.867e-02	1.165	6 ADRA1D, GPR26, HTR1A, MC4R, NPY2R, OPRD1	67	G-protein signaling, coupled to cAMP nucleotide second messenger
GO:0007611	2.918e-02	1.6	7 CRH, GRIN2B, GRPR, HTR2A, NETO1, SHC3, TACR1	92	learning or memory
GO:0046058	3.343e-02	1.652	7 ADCYAP1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	95	cAMP metabolic process
GO:0030799	3.499e-02	1.67	7 ADCYAP1, GPR26, HTR1A, HTR1B, MC4R, NPY2R, OPRD1	96	regulation of cyclic nucleotide metabolic process
GO:0031644	3.692e-02	2.174	8 ARC, CARTPT, GRIN2B, HTR1B, HTR2A, NETO1, OPRD1, TACR1	125	regulation of neurological system process
GO:0007270	3.781e-02	0.8523	5 DLGAP2, HTR1B, HTR2A, SHC3, TACR1	49	nerve-nerve synaptic transmission
GO:0050890	3.815e-02	1.705	7 CRH, GRIN2B, GRPR, HTR2A, NETO1, SHC3, TACR1	98	cognition
GO:0006816	3.853e-02	2.713	9 CACNG3, CLCA1, GRIN2B, HTR2A, HTR2C, OPRD1, SLC24A4, SLC8A3, TRPC5	156	calcium ion transport
GO:0007417	3.884e-02	6.297	15 BCL11B, DLX1, DLX2, IL1RAPL2, MAS1, MYO16, NDEL1, OTX1, PCSK1, RORB, SHC3, SLIT1, TBR1, WNT1, WNT7A	362	central nervous system development
GO:0010721	4.034e-02	0.8697	5 DLX1, DLX2, SLIT1, WNT7A, XYLT1	50	negative regulation of cell development
GO:0008628	4.165e-02	0.06958	2 CRH, SST	4	induction of apoptosis by hormones
GO:0035081	4.165e-02	0.06958	2 CRH, SST	4	induction of programmed cell death by hormones
GO:0060054	4.165e-02	0.06958	2 FGF10, WNT7A	4	positive regulation of epithelial cell proliferation involved in wound healing
GO:0051234	4.575e-02	39.17	56 ANO3, ARC, CACNG3, CARTPT, CLCA1, CRH, DBI, ELMOD2, FGF10, GABRA4, GABRQ, GLRA3, GRIN2B, HTR1B, HTR2A, HTR2C, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, MC4R, NDEL1, NGB, OPRD1, PCSK1, PDE8B, RAB3B, SLC10A4, SLC13A4, SLC24A4, SLC35D3, SLC6A7, SLC7A3, SLC8A3, SLIT1, SYT6, TACR1, TRAPPC10, TRPC5, VIP, WNT7A	2252	establishment of localization
GO:0007165	4.704e-02	30.54	46 ADRA1D, CARTPT, CHRM1, CHRM3, CNTNAP5, CRH, FGF10, FIBCD1, FSHB, GABRQ, GPR123, GPR26, GRIN2B, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR4, HTR6, IL1RAPL2, MAPK3, MAS1, MC4R, NLK, NPY2R, NRG3, OPN4, OPRD1, PDE2A, PLXNA4, PNOC, PRKG2, RAB3B, RASL10A, RGS4, RXFP3, SHC3, SLC7A3, SPRED3, SYNGAP1, TACR1, UNC5D, WNT16	1756	signal transduction
GO:0070838	4.793e-02	2.835	9 CACNG3, CLCA1, GRIN2B, HTR2A, HTR2C, OPRD1, SLC24A4, SLC8A3, TRPC5	163	divalent metal ion transport

Id	Pvalue	ExpCount	Count	Size	Term
GO:0016021	2.640e-17	65.22	128 ADRA1D, ALK, ANO3, ATRNL1, B3GNT4, C11orf87, C13orf36, C1orf95, C5orf40, C6orf72, CACNG3, CALHM3, CDH4, CDH8, CDH9, CHRM1, CHRM3, CHST1, CLCA1, CNTNAP5, CSMD2, DSCAM, ELFN2, EPHA5, EPHX4, FIBCD1, FLRT2, FREM3, GABRA4, GABRQ, GALNTL6, GJD2, GLRA3, GP5, GPR123, GPR150, GPR26, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LECT1, LMTK2, LPPR3, LPPR4, LPPR5, LRFN2, LRFN5, LRRC55, LRTM2, MARCH1, MARCH4, MAS1, MC4R, MGAT5B, MMD, MMP16, MMP17, NETO1, NPY2R, NRG3, OPN4, OPRD1, OR10G7, OR2AG2, PCDH19, PCDH20, PCDH8, PLD3, PLXNA4, PRLHR, PROKR2, PRRG3, PTPRA, RNF24, RXFP3, SLC10A4, SLC13A4, SLC24A4, SLC35D3, SLC35E4, SLC6A7, SLC7A3, SLC8A3, SLITRK1, ST6GALNAC5, STYK1, SYT6, TACR1, TCEB3, TMEM132D, TMEM179, TMEM200A, TRAPPC10, TRHR, TRPC5, UNC5D, XKR4, XYLT1, ZDHHC22	3638	integral to membrane
GO:0031224	5.362e-17	66.64	129 ADRA1D, ALK, ANO3, ATRNL1, B3GNT4, C11orf87, C13orf36, C1orf95, C5orf40, C6orf72, CACNG3, CALHM3, CDH4, CDH8, CDH9, CHRM1, CHRM3, CHST1, CLCA1, CNTN3, CNTNAP5, CSMD2, DSCAM, ELFN2, EPHA5, EPHX4, FIBCD1, FLRT2, FREM3, GABRA4, GABRQ, GALNTL6, GJD2, GLRA3, GP5, GPR123, GPR150, GPR26, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LECT1, LMTK2, LPPR3, LPPR4, LPPR5, LRFN2, LRFN5, LRRC55, LRTM2, MARCH1, MARCH4, MAS1, MC4R, MGAT5B, MMD, MMP16, MMP17, NETO1, NPY2R, NRG3, OPN4, OPRD1, OR10G7, OR2AG2, PCDH19, PCDH20, PCDH8, PLD3, PLXNA4, PRLHR, PROKR2, PRRG3, PTPRA, RNF24, RXFP3, SLC10A4, SLC13A4, SLC24A4, SLC35D3, SLC35E4, SLC6A7, SLC7A3, SLC8A3, SLITRK1, ST6GALNAC5, STYK1, SYT6, TACR1, TCEB3, TMEM132D, TMEM179, TMEM200A, TRAPPC10, TRHR, TRPC5, UNC5D, XKR4, XYLT1, ZDHHC22	3717	intrinsic to membrane
GO:0005887	2.104e-14	16.56	56 ADRA1D, ALK, CDH4, CHRM1, CHRM3, CLCA1, DSCAM, EPHA5, FLRT2, GABRA4, GABRQ, GP5, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR3A, HTR4, HTR6, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH4, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LPPR4, MAS1, MMD, MMP16, MMP17, NPY2R, NRG3, OPRD1, PCDH8, PRLHR, PTPRA, RXFP3, SLC13A4, SLC6A7, TACR1, TRHR, TRPC5	924	integral to plasma membrane
GO:0031226	5.098e-14	16.92	56 ADRA1D, ALK, CDH4, CHRM1, CHRM3, CLCA1, DSCAM, EPHA5, FLRT2, GABRA4, GABRQ, GP5, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR3A, HTR4, HTR6, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH4, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LPPR4, MAS1, MMD, MMP16, MMP17, NPY2R, NRG3, OPRD1, PCDH8, PRLHR, PTPRA, RXFP3, SLC13A4, SLC6A7, TACR1, TRHR, TRPC5	944	intrinsic to plasma membrane
GO:0044425	1.540e-13	76.85	133 ADRA1D, ALK, ANO3, ARC, ATRNL1, B3GNT4, C11orf87, C13orf36, C1orf95, C5orf40, C6orf72, CACNG3, CALHM3, CAMK2A, CBLN4, CDH4, CDH8, CDH9, CHRM1, CHRM3, CHST1, CLCA1, CNTN3, CNTNAP5, CSMD2, DLGAP2, DSCAM, ELFN2, EPHA5, EPHX4, FIBCD1, FLRT2, FREM3, GABRA4, GABRQ, GALNTL6, GJD2, GLRA3, GP5, GPR123, GPR150, GPR26, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LECT1, LMTK2, LPPR3, LPPR4, LPPR5, LRFN2, LRFN5, LRRC55, LRTM2, MARCH1, MARCH4, MAS1, MC4R, MGAT5B, MMD, MMP16, MMP17, NETO1, NPY2R, NRG3, OPN4, OPRD1, OR10G7, OR2AG2, PCDH19, PCDH20, PCDH8, PLD3, PLXNA4, PRLHR, PROKR2, PRRG3, PTPRA, RNF24, RXFP3, SLC10A4, SLC13A4, SLC24A4, SLC35D3, SLC35E4, SLC6A7, SLC7A3, SLC8A3, SLITRK1, ST6GALNAC5, STYK1, SYT6, TACR1, TCEB3, TMEM132D, TMEM179, TMEM200A, TRAPPC10, TRHR, TRPC5, UNC5D, XKR4, XYLT1, ZDHHC22	4287	membrane part
GO:0008076	1.135e-11	1.291	16 KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH4, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	72	voltage-gated potassium channel complex
GO:0034705	1.135e-11	1.291	16 KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH4, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	72	potassium channel complex
GO:0034702	3.019e-11	3.048	22 ANO3, CACNG3, GABRA4, GABRQ, GLRA3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH4, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, TRPC5	170	ion channel complex
GO:0034703	1.140e-10	2.026	18 CACNG3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH4, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, TRPC5	113	cation channel complex
GO:0005886	1.902e-10	47.04	92 ADRA1D, ALK, ARC, CACNG3, CAMK2A, CBLN4, CDH4, CDH8, CDH9, CHRM1, CHRM3, CLCA1, CNTN3, CSMD2, DGKB, DLGAP2, DSCAM, EPHA5, FGF10, FLRT2, GABRA4, GABRQ, GJD2, GLRA3, GP5, GPR123, GPR150, GPR26, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH4, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LPPR4, LRFN2, MARCH1, MAS1, MC4R, MMD, MMP16, MMP17, MYO16, NETO1, NPY2R, NRG3, OPRD1, OR10G7, OR2AG2, PCDH19, PCDH20, PCDH8, PDYN, PLXNA4, PRLHR, PROKR2, PTPRA, RAB3B, RASL10A, RXFP3, SLC13A4, SLC6A7, SLC7A3, SPRED3, STYK1, SYT6, TACR1, TRHR, TRPC5	2624	plasma membrane
GO:0016020	2.996e-10	92.29	141 ADRA1D, ALK, ANO3, ARC, ATRNL1, B3GNT4, C11orf87, C13orf36, C1orf95, C5orf40, C6orf72, CACNG3, CALHM3, CAMK2A, CBLN4, CDH4, CDH8, CDH9, CHRM1, CHRM3, CHST1, CLCA1, CNTN3, CNTNAP5, CSMD2, DGKB, DLGAP2, DSCAM, ELFN2, EPHA5, EPHX4, FGF10, FIBCD1, FLRT2, FREM3, GABRA4, GABRQ, GALNTL6, GJD2, GLRA3, GP5, GPR123, GPR150, GPR26, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LECT1, LMTK2, LPPR3, LPPR4, LPPR5, LRFN2, LRFN5, LRRC55, LRTM2, MARCH1, MARCH4, MAS1, MC4R, MGAT5B, MMD, MMP16, MMP17, MYO16, NETO1, NPY2R, NRG3, OPN4, OPRD1, OR10G7, OR2AG2, PCDH19, PCDH20, PCDH8, PDE2A, PDYN, PLD3, PLXNA4, PRLHR, PROKR2, PRRG3, PTPRA, RAB3B, RASL10A, RNF24, RXFP3, SLC10A4, SLC13A4, SLC24A4, SLC35D3, SLC35E4, SLC6A7, SLC7A3, SLC8A3, SLITRK1, SPRED3, ST6GALNAC5, STYK1, SYT6, TACR1, TCEB3, TMEM132D, TMEM179, TMEM200A, TRAPPC10, TRHR, TRPC5, UNC5D, XKR4, XYLT1, ZDHHC22	5148	membrane
GO:0044459	9.497e-10	28.54	66 ADRA1D, ALK, ARC, CACNG3, CAMK2A, CBLN4, CDH4, CHRM1, CHRM3, CLCA1, DLGAP2, DSCAM, EPHA5, FLRT2, GABRA4, GABRQ, GJD2, GLRA3, GP5, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR3A, HTR4, HTR6, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH4, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, LPPR4, LRFN2, MAS1, MMD, MMP16, MMP17, NETO1, NPY2R, NRG3, OPRD1, PCDH8, PRLHR, PTPRA, RXFP3, SLC13A4, SLC6A7, SYT6, TACR1, TRHR, TRPC5	1592	plasma membrane part
GO:0045211	1.231e-05	2.241	13 ARC, CHRM1, CHRM3, DLGAP2, GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCTD16, LRFN2, NETO1, OPRD1	125	postsynaptic membrane
GO:0044456	5.139e-05	3.89	16 ARC, CAMK2A, CHRM1, CHRM3, DLGAP2, GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCTD16, LRFN2, NETO1, OPRD1, RAB3B, SYT6	217	synapse part
GO:0045202	4.191e-04	5.199	17 ARC, CAMK2A, CBLN4, CHRM1, CHRM3, DLGAP2, GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCTD16, LRFN2, NETO1, OPRD1, RAB3B, SYT6	290	synapse
GO:0031012	8.951e-03	5.109	14 ADAMTS8, DSPP, FGF10, FLRT2, FREM3, GRIN2B, KAL1, MEPE, MMP16, MMP17, WNT1, WNT10B, WNT16, WNT7A	285	extracellular matrix
GO:0033267	1.055e-02	1.094	6 CHRM1, CHRM3, DLGAP2, HTR1A, OPRD1, PCSK1	61	axon part
GO:0005578	1.550e-02	4.267	12 ADAMTS8, DSPP, FLRT2, FREM3, KAL1, MEPE, MMP16, MMP17, WNT1, WNT10B, WNT16, WNT7A	238	proteinaceous extracellular matrix
GO:0030425	1.800e-02	2.671	9 ARC, CHRM1, CHRM3, DLGAP2, FRMPD4, GRIN2B, HTR2A, PCSK1, TACR1	149	dendrite
GO:0043679	2.782e-02	0.5737	4 CHRM1, CHRM3, OPRD1, PCSK1	32	axon terminus
GO:0044306	2.782e-02	0.5737	4 CHRM1, CHRM3, OPRD1, PCSK1	32	neuron projection terminus
GO:0032279	3.369e-02	0.08964	2 CHRM1, CHRM3	5	asymmetric synapse
GO:0043005	3.727e-02	5.486	13 ARC, CHRM1, CHRM3, DLGAP2, DSCAM, FRMPD4, GRIN2B, HTR1A, HTR2A, NDEL1, OPRD1, PCSK1, TACR1	306	neuron projection
GO:0030054	4.024e-02	7.565	16 ARC, CAMK2A, CBLN4, CHRM1, CHRM3, DLGAP2, GABRA4, GABRQ, GJD2, GLRA3, GRIN2B, HTR3A, KCTD16, LRFN2, NETO1, SYT6	422	cell junction

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005249	1.567e-12	1.436	18 KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	81	voltage-gated potassium channel activity
GO:0008227	1.265e-11	0.5141	12 ADRA1D, CHRM1, CHRM3, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6	29	G-protein coupled amine receptor activity
GO:0022843	6.941e-11	2.092	19 CACNG3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	118	voltage-gated cation channel activity
GO:0004930	8.677e-11	6.452	31 ADRA1D, CHRM1, CHRM3, GPR123, GPR150, GPR26, GPR83, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, MAS1, MC4R, NPY2R, OPN4, OPRD1, OR10G7, OR2AG2, PRLHR, PROKR2, RORB, RXFP3, TACR1, TRHR	364	G-protein coupled receptor activity
GO:0005267	1.500e-10	1.914	18 KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	108	potassium channel activity
GO:0022836	3.767e-10	4.378	25 CACNG3, GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, TRPC5	247	gated channel activity
GO:0015267	6.012e-10	5.708	28 ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GJD2, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, TRPC5	322	channel activity
GO:0022803	6.388e-10	5.726	28 ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GJD2, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, TRPC5	323	passive transmembrane transporter activity
GO:0005216	7.119e-10	5.336	27 ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, TRPC5	301	ion channel activity
GO:0022838	1.408e-09	5.513	27 ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, TRPC5	311	substrate-specific channel activity
GO:0005244	4.756e-09	2.73	19 CACNG3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	154	voltage-gated ion channel activity
GO:0022832	4.756e-09	2.73	19 CACNG3, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4	154	voltage-gated channel activity
GO:0004871	6.634e-09	23.82	58 ADCYAP1, ADRA1D, ALK, CHRM1, CHRM3, EPHA5, FLRT2, GABRA4, GABRQ, GLRA3, GPR123, GPR150, GPR26, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, KCNH3, KCNH4, KCNH7, MAPK3, MAS1, MC4R, MMD, NETO1, NLK, NPY2R, NRG3, OPN4, OPRD1, OR10G7, OR2AG2, PDE8B, PLXNA4, PRLHR, PROKR2, PTPRA, RGS4, RORB, RXFP3, SHC3, TACR1, TRHR, UNC5D, WNT1, WNT10B, WNT16, WNT7A	1344	signal transducer activity
GO:0060089	6.634e-09	23.82	58 ADCYAP1, ADRA1D, ALK, CHRM1, CHRM3, EPHA5, FLRT2, GABRA4, GABRQ, GLRA3, GPR123, GPR150, GPR26, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, KCNH3, KCNH4, KCNH7, MAPK3, MAS1, MC4R, MMD, NETO1, NLK, NPY2R, NRG3, OPN4, OPRD1, OR10G7, OR2AG2, PDE8B, PLXNA4, PRLHR, PROKR2, PTPRA, RGS4, RORB, RXFP3, SHC3, TACR1, TRHR, UNC5D, WNT1, WNT10B, WNT16, WNT7A	1344	molecular transducer activity
GO:0005261	8.111e-09	3.918	22 CACNG3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, TRPC5	221	cation channel activity
GO:0004888	8.624e-09	12.12	39 ADRA1D, ALK, CHRM1, CHRM3, EPHA5, GABRA4, GABRQ, GPR123, GPR150, GPR26, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, MAS1, MC4R, NPY2R, OPN4, OPRD1, OR10G7, OR2AG2, PLXNA4, PRLHR, PROKR2, PTPRA, RORB, RXFP3, TACR1, TRHR	684	transmembrane receptor activity
GO:0004993	2.361e-08	0.195	7 HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4	11	serotonin receptor activity
GO:0051378	2.982e-08	0.1241	6 HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A	7	serotonin binding
GO:0015075	3.891e-08	10.02	34 ADAMTS8, ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SLC10A4, SLC13A4, SLC6A7, SLC7A3, SLC8A3, TRAPPC10, TRPC5	565	ion transmembrane transporter activity
GO:0008324	3.581e-07	7.747	28 CACNG3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SLC10A4, SLC13A4, SLC6A7, SLC7A3, SLC8A3, TRAPPC10, TRPC5	437	cation transmembrane transporter activity
GO:0042165	5.115e-07	1.028	11 CHRM1, CHRM3, GABRA4, GPR83, GRIN2B, GRPR, HCRTR2, NPY2R, PRLHR, PROKR2, TACR1	58	neurotransmitter binding
GO:0022857	9.037e-07	12.62	36 ADAMTS8, ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GJD2, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SLC10A4, SLC13A4, SLC24A4, SLC6A7, SLC7A3, SLC8A3, TRAPPC10, TRPC5	712	transmembrane transporter activity
GO:0022891	1.025e-06	11.5	34 ADAMTS8, ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, SLC10A4, SLC13A4, SLC6A7, SLC7A3, SLC8A3, TRAPPC10, TRPC5	649	substrate-specific transmembrane transporter activity
GO:0030594	1.420e-06	0.8863	10 CHRM1, CHRM3, GABRA4, GPR83, GRPR, HCRTR2, NPY2R, PRLHR, PROKR2, TACR1	50	neurotransmitter receptor activity
GO:0004872	2.282e-06	17.58	43 ADRA1D, ALK, CHRM1, CHRM3, EPHA5, GABRA4, GABRQ, GLRA3, GPR123, GPR150, GPR26, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A, HTR4, HTR6, IL1RAPL2, MAS1, MC4R, MMD, NETO1, NPY2R, OPN4, OPRD1, OR10G7, OR2AG2, PLXNA4, PRLHR, PROKR2, PTPRA, RORB, RXFP3, TACR1, TRHR, UNC5D	992	receptor activity
GO:0042923	4.411e-06	0.5495	8 GPR83, GRPR, HCRTR2, MC4R, NPY2R, PRLHR, PROKR2, TACR1	31	neuropeptide binding
GO:0022892	1.001e-05	13.37	35 ADAMTS8, ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, NGB, SLC10A4, SLC13A4, SLC6A7, SLC7A3, SLC8A3, TRAPPC10, TRPC5	754	substrate-specific transporter activity
GO:0001653	1.555e-05	1.454	11 GPR83, GRPR, HCRTR2, MAS1, MC4R, NPY2R, OPRD1, PRLHR, PROKR2, RXFP3, TACR1	82	peptide receptor activity
GO:0008528	1.555e-05	1.454	11 GPR83, GRPR, HCRTR2, MAS1, MC4R, NPY2R, OPRD1, PRLHR, PROKR2, RXFP3, TACR1	82	peptide receptor activity, G-protein coupled
GO:0005215	3.666e-05	16.17	38 ADAMTS8, ANO3, CACNG3, CLCA1, GABRA4, GABRQ, GJD2, GLRA3, GRIN2B, HTR3A, KCNA3, KCNA4, KCNA6, KCNB2, KCNC2, KCNF1, KCNG1, KCNG3, KCNH3, KCNH4, KCNH7, KCNQ3, KCNQ5, KCNS1, KCNS2, KCNV1, KCTD16, KCTD4, NGB, SLC10A4, SLC13A4, SLC24A4, SLC6A7, SLC7A3, SLC8A3, SYT6, TRAPPC10, TRPC5	912	transporter activity
GO:0008188	5.084e-05	0.5318	7 GPR83, GRPR, HCRTR2, NPY2R, PRLHR, PROKR2, TACR1	30	neuropeptide receptor activity
GO:0004983	5.713e-04	0.1595	4 GPR83, NPY2R, PRLHR, PROKR2	9	neuropeptide Y receptor activity
GO:0042277	7.737e-04	2.694	12 GPR83, GRPR, HCRTR2, MAS1, MC4R, NPY2R, OPRD1, PCSK1, PRLHR, PROKR2, RXFP3, TACR1	152	peptide binding
GO:0043176	1.130e-03	1.56	9 CHRM1, CHRM3, GRIN2B, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR3A	88	amine binding
GO:0017046	2.640e-03	0.4432	5 HCRTR2, MAS1, MC4R, PCSK1, PRLHR	25	peptide hormone binding
GO:0008144	4.674e-03	0.7977	6 CHRM1, CHRM3, HTR1A, HTR1B, HTR2A, HTR2C	45	drug binding
GO:0005184	6.290e-03	0.3014	4 ADCYAP1, CRH, PNOC, VIP	17	neuropeptide hormone activity
GO:0008081	1.044e-02	1.329	7 CHRM1, CHRM3, HTR2A, HTR2C, PDE2A, PDE8B, PLD3	75	phosphoric diester hydrolase activity
GO:0015276	1.130e-02	1.773	8 GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCNH7, KCNQ5, TRPC5	100	ligand-gated ion channel activity
GO:0022834	1.130e-02	1.773	8 GABRA4, GABRQ, GLRA3, GRIN2B, HTR3A, KCNH7, KCNQ5, TRPC5	100	ligand-gated channel activity
GO:0005251	1.213e-02	0.1595	3 KCNA3, KCNB2, KCNS1	9	delayed rectifier potassium channel activity
GO:0042562	1.871e-02	0.7268	5 HCRTR2, MAS1, MC4R, PCSK1, PRLHR	41	hormone binding
GO:0004434	2.186e-02	0.4432	4 CHRM1, CHRM3, HTR2A, HTR2C	25	inositol or phosphatidylinositol phosphodiesterase activity
GO:0004435	2.186e-02	0.4432	4 CHRM1, CHRM3, HTR2A, HTR2C	25	phosphoinositide phospholipase C activity
GO:0004981	2.226e-02	0.05318	2 CHRM1, CHRM3	3	muscarinic acetylcholine receptor activity
GO:0016907	2.226e-02	0.05318	2 CHRM1, CHRM3	3	G-protein coupled acetylcholine receptor activity
GO:0004629	3.328e-02	0.5141	4 CHRM1, CHRM3, HTR2A, HTR2C	29	phospholipase C activity
GO:0005179	3.464e-02	1.276	6 ADCYAP1, CRH, FSHB, PNOC, SST, VIP	72	hormone activity
GO:0001515	3.676e-02	0.07091	2 PDYN, PNOC	4	opioid peptide activity
GO:0005254	4.806e-02	0.9572	5 ANO3, CLCA1, GABRA4, GABRQ, GLRA3	54	chloride channel activity

Id	Pvalue	ExpCount	Count	Size	Term
04080	2.039e-13	3.759	26 ADRA1D, CHRM1, CHRM3, FSHB, GABRA4, GABRQ, GLRA3, GPR83, GRIN2B, GRPR, HCRTR2, HRH1, HTR1A, HTR1B, HTR1E, HTR2A, HTR2C, HTR4, HTR6, MAS1, MC4R, NPY2R, OPRD1, PRLHR, TACR1, TRHR	206	Neuroactive ligand-receptor interaction
04020	7.369e-05	2.646	13 ADRA1D, CAMK2A, CHRM1, CHRM3, GRPR, HRH1, HTR2A, HTR2C, HTR4, HTR6, SLC8A3, TACR1, TRHR	145	Calcium signaling pathway

No enriched terms

No enriched terms

Entrez genes

ABHD12Babhydrolase domain containing 12B (ENSG00000131969), score: 0.68 ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif, 8 (ENSG00000134917), score: 0.69 ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary) (ENSG00000141433), score: 0.7 ADRA1Dadrenergic, alpha-1D-, receptor (ENSG00000171873), score: 0.74 AGBL4ATP/GTP binding protein-like 4 (ENSG00000186094), score: 0.65 AIREautoimmune regulator (ENSG00000160224), score: 0.67 AK5adenylate kinase 5 (ENSG00000154027), score: 0.66 ALKanaplastic lymphoma receptor tyrosine kinase (ENSG00000171094), score: 0.72 ANO3anoctamin 3 (ENSG00000134343), score: 0.66 ARCactivity-regulated cytoskeleton-associated protein (ENSG00000198576), score: 0.68 ATRNL1attractin-like 1 (ENSG00000107518), score: 0.65 B3GNT4UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 (ENSG00000176383), score: 0.65 BCL11BB-cell CLL/lymphoma 11B (zinc finger protein) (ENSG00000127152), score: 0.7 BTBD9BTB (POZ) domain containing 9 (ENSG00000183826), score: 0.78 C11orf87chromosome 11 open reading frame 87 (ENSG00000185742), score: 0.7 C12orf41chromosome 12 open reading frame 41 (ENSG00000139620), score: -0.66 C13orf36chromosome 13 open reading frame 36 (ENSG00000180440), score: 0.82 C1orf95chromosome 1 open reading frame 95 (ENSG00000203685), score: 0.67 C1QL2complement component 1, q subcomponent-like 2 (ENSG00000144119), score: 0.7 C5orf40chromosome 5 open reading frame 40 (ENSG00000172568), score: 0.68 C6orf72chromosome 6 open reading frame 72 (ENSG00000055211), score: -0.69 CACNG3calcium channel, voltage-dependent, gamma subunit 3 (ENSG00000006116), score: 0.7 CALHM3calcium homeostasis modulator 3 (ENSG00000183128), score: 0.76 CAMK2Acalcium/calmodulin-dependent protein kinase II alpha (ENSG00000070808), score: 0.67 CAPN14calpain 14 (ENSG00000214711), score: 0.7 CARTPTCART prepropeptide (ENSG00000164326), score: 0.65 CBLN4cerebellin 4 precursor (ENSG00000054803), score: 0.76 CDH4cadherin 4, type 1, R-cadherin (retinal) (ENSG00000179242), score: 0.75 CDH8cadherin 8, type 2 (ENSG00000150394), score: 0.74 CDH9cadherin 9, type 2 (T1-cadherin) (ENSG00000113100), score: 0.68 CDKL5cyclin-dependent kinase-like 5 (ENSG00000008086), score: 0.66 CHRM1cholinergic receptor, muscarinic 1 (ENSG00000168539), score: 0.69 CHRM3cholinergic receptor, muscarinic 3 (ENSG00000133019), score: 0.77 CHST1carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (ENSG00000175264), score: 0.69 CLCA1chloride channel accessory 1 (ENSG00000016490), score: 0.72 CNTN3contactin 3 (plasmacytoma associated) (ENSG00000113805), score: 0.69 CNTNAP5contactin associated protein-like 5 (ENSG00000155052), score: 0.8 CRHcorticotropin releasing hormone (ENSG00000147571), score: 0.69 CRYGAcrystallin, gamma A (ENSG00000168582), score: 0.89 CSMD2CUB and Sushi multiple domains 2 (ENSG00000121904), score: 0.65 DBIdiazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) (ENSG00000155368), score: -0.65 DBX2developing brain homeobox 2 (ENSG00000185610), score: 0.66 DDX47DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 (ENSG00000213782), score: -0.69 DGKBdiacylglycerol kinase, beta 90kDa (ENSG00000136267), score: 0.66 DLGAP2discs, large (Drosophila) homolog-associated protein 2 (ENSG00000198010), score: 0.65 DLX1distal-less homeobox 1 (ENSG00000144355), score: 0.73 DLX2distal-less homeobox 2 (ENSG00000115844), score: 0.69 DNAH5dynein, axonemal, heavy chain 5 (ENSG00000039139), score: 0.66 DSCAMDown syndrome cell adhesion molecule (ENSG00000171587), score: 0.65 DSPPdentin sialophosphoprotein (ENSG00000152591), score: 0.7 EGR3early growth response 3 (ENSG00000179388), score: 0.7 ELFN2extracellular leucine-rich repeat and fibronectin type III domain containing 2 (ENSG00000166897), score: 0.65 ELMOD2ELMO/CED-12 domain containing 2 (ENSG00000179387), score: -0.66 ENC1ectodermal-neural cortex 1 (with BTB-like domain) (ENSG00000171617), score: 0.67 EPHA5EPH receptor A5 (ENSG00000145242), score: 0.71 EPHX4epoxide hydrolase 4 (ENSG00000172031), score: 0.64 FAM19A1family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 (ENSG00000183662), score: 0.72 FAM92Bfamily with sequence similarity 92, member B (ENSG00000153789), score: 0.8 FBXL18F-box and leucine-rich repeat protein 18 (ENSG00000155034), score: 0.67 FERD3LFer3-like (Drosophila) (ENSG00000146618), score: 0.93 FGF10fibroblast growth factor 10 (ENSG00000070193), score: 0.78 FIBCD1fibrinogen C domain containing 1 (ENSG00000130720), score: 0.68 FLRT2fibronectin leucine rich transmembrane protein 2 (ENSG00000185070), score: 0.67 FREM3FRAS1 related extracellular matrix 3 (ENSG00000183090), score: 0.83 FRMPD4FERM and PDZ domain containing 4 (ENSG00000169933), score: 0.65 FSHBfollicle stimulating hormone, beta polypeptide (ENSG00000131808), score: 0.74 GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 4 (ENSG00000109158), score: 0.65 GABRQgamma-aminobutyric acid (GABA) receptor, theta (ENSG00000147402), score: 0.96 GALNTL6UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6 (ENSG00000174473), score: 0.68 GJD2gap junction protein, delta 2, 36kDa (ENSG00000159248), score: 0.66 GLRA3glycine receptor, alpha 3 (ENSG00000145451), score: 0.7 GP5glycoprotein V (platelet) (ENSG00000178732), score: 0.73 GPR123G protein-coupled receptor 123 (ENSG00000197177), score: 0.74 GPR150G protein-coupled receptor 150 (ENSG00000178015), score: 0.8 GPR26G protein-coupled receptor 26 (ENSG00000154478), score: 0.73 GPR83G protein-coupled receptor 83 (ENSG00000123901), score: 0.67 GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B (ENSG00000150086), score: 0.74 HCRTR2hypocretin (orexin) receptor 2 (ENSG00000137252), score: 0.7 HOPXHOP homeobox (ENSG00000171476), score: 0.64 HRH1histamine receptor H1 (ENSG00000196639), score: 0.7 HSPBP1HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 (ENSG00000133265), score: 0.69 HTR1A5-hydroxytryptamine (serotonin) receptor 1A (ENSG00000178394), score: 0.87 HTR1B5-hydroxytryptamine (serotonin) receptor 1B (ENSG00000135312), score: 0.71 HTR1E5-hydroxytryptamine (serotonin) receptor 1E (ENSG00000168830), score: 0.72 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (ENSG00000102468), score: 0.72 HTR2C5-hydroxytryptamine (serotonin) receptor 2C (ENSG00000147246), score: 0.92 HTR3A5-hydroxytryptamine (serotonin) receptor 3A (ENSG00000166736), score: 0.77 HTR45-hydroxytryptamine (serotonin) receptor 4 (ENSG00000164270), score: 0.9 HTR65-hydroxytryptamine (serotonin) receptor 6 (ENSG00000158748), score: 0.99 IL1RAPL2interleukin 1 receptor accessory protein-like 2 (ENSG00000189108), score: 0.76 INSM2insulinoma-associated 2 (ENSG00000168348), score: 0.68 KAL1Kallmann syndrome 1 sequence (ENSG00000011201), score: 0.67 KCNA3potassium voltage-gated channel, shaker-related subfamily, member 3 (ENSG00000177272), score: 0.79 KCNA4potassium voltage-gated channel, shaker-related subfamily, member 4 (ENSG00000182255), score: 0.78 KCNA6potassium voltage-gated channel, shaker-related subfamily, member 6 (ENSG00000151079), score: 0.67 KCNB2potassium voltage-gated channel, Shab-related subfamily, member 2 (ENSG00000182674), score: 0.76 KCNC2potassium voltage-gated channel, Shaw-related subfamily, member 2 (ENSG00000166006), score: 0.66 KCNF1potassium voltage-gated channel, subfamily F, member 1 (ENSG00000162975), score: 0.7 KCNG1potassium voltage-gated channel, subfamily G, member 1 (ENSG00000026559), score: 0.73 KCNG3potassium voltage-gated channel, subfamily G, member 3 (ENSG00000171126), score: 0.68 KCNH3potassium voltage-gated channel, subfamily H (eag-related), member 3 (ENSG00000135519), score: 0.67 KCNH4potassium voltage-gated channel, subfamily H (eag-related), member 4 (ENSG00000089558), score: 0.8 KCNH7potassium voltage-gated channel, subfamily H (eag-related), member 7 (ENSG00000184611), score: 0.7 KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 3 (ENSG00000184156), score: 0.65 KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5 (ENSG00000185760), score: 0.67 KCNS1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 (ENSG00000124134), score: 0.72 KCNS2potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 (ENSG00000156486), score: 0.75 KCNV1potassium channel, subfamily V, member 1 (ENSG00000164794), score: 0.77 KCTD16potassium channel tetramerisation domain containing 16 (ENSG00000183775), score: 0.71 KCTD4potassium channel tetramerisation domain containing 4 (ENSG00000180332), score: 0.71 LECT1leukocyte cell derived chemotaxin 1 (ENSG00000136110), score: 0.74 LMO4LIM domain only 4 (ENSG00000143013), score: 0.65 LMTK2lemur tyrosine kinase 2 (ENSG00000164715), score: 0.66 LOC100293905similar to gastrin-releasing peptide receptor (ENSG00000126010), score: 0.8 LPPR3lipid phosphate phosphatase-related protein type 3 (ENSG00000129951), score: 0.69 LPPR4lipid phosphate phosphatase-related protein type 4 (ENSG00000117600), score: 0.72 LPPR5lipid phosphate phosphatase-related protein type 5 (ENSG00000117598), score: 0.76 LRFN2leucine rich repeat and fibronectin type III domain containing 2 (ENSG00000156564), score: 0.75 LRFN5leucine rich repeat and fibronectin type III domain containing 5 (ENSG00000165379), score: 0.66 LRRC55leucine rich repeat containing 55 (ENSG00000183908), score: 0.79 LRTM2leucine-rich repeats and transmembrane domains 2 (ENSG00000166159), score: 0.74 MAMLD1mastermind-like domain containing 1 (ENSG00000013619), score: 0.66 MAPK3mitogen-activated protein kinase 3 (ENSG00000102882), score: 0.72 MARCH1membrane-associated ring finger (C3HC4) 1 (ENSG00000145416), score: 0.67 MARCH4membrane-associated ring finger (C3HC4) 4 (ENSG00000144583), score: 0.67 MAS1MAS1 oncogene (ENSG00000130368), score: 0.66 MAST3microtubule associated serine/threonine kinase 3 (ENSG00000099308), score: 0.67 MC4Rmelanocortin 4 receptor (ENSG00000166603), score: 0.68 MEF2Cmyocyte enhancer factor 2C (ENSG00000081189), score: 0.66 MEPEmatrix extracellular phosphoglycoprotein (ENSG00000152595), score: 0.81 MGAT5Bmannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (ENSG00000167889), score: 0.64 MKL2MKL/myocardin-like 2 (ENSG00000186260), score: 0.69 MMDmonocyte to macrophage differentiation-associated (ENSG00000108960), score: 0.65 MMP16matrix metallopeptidase 16 (membrane-inserted) (ENSG00000156103), score: 0.64 MMP17matrix metallopeptidase 17 (membrane-inserted) (ENSG00000198598), score: 0.67 MYO16myosin XVI (ENSG00000041515), score: 0.71 NAA38N(alpha)-acetyltransferase 38, NatC auxiliary subunit (ENSG00000128534), score: -0.64 NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (ENSG00000166579), score: 0.68 NETO1neuropilin (NRP) and tolloid (TLL)-like 1 (ENSG00000166342), score: 0.72 NEUROD6neurogenic differentiation 6 (ENSG00000164600), score: 0.68 NFATC3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (ENSG00000072736), score: -0.64 NGBneuroglobin (ENSG00000165553), score: 0.65 NLKnemo-like kinase (ENSG00000087095), score: 0.73 NPY2Rneuropeptide Y receptor Y2 (ENSG00000185149), score: 0.77 NRG3neuregulin 3 (ENSG00000185737), score: 0.66 OPN4opsin 4 (ENSG00000122375), score: 0.77 OPRD1opioid receptor, delta 1 (ENSG00000116329), score: 0.87 OR10G7olfactory receptor, family 10, subfamily G, member 7 (ENSG00000182634), score: 0.71 OR2AG2olfactory receptor, family 2, subfamily AG, member 2 (ENSG00000188124), score: 0.69 OTX1orthodenticle homeobox 1 (ENSG00000115507), score: 0.67 PCDH19protocadherin 19 (ENSG00000165194), score: 0.83 PCDH20protocadherin 20 (ENSG00000197991), score: 0.72 PCDH8protocadherin 8 (ENSG00000136099), score: 0.76 PCSK1proprotein convertase subtilisin/kexin type 1 (ENSG00000175426), score: 0.73 PDE2Aphosphodiesterase 2A, cGMP-stimulated (ENSG00000186642), score: 0.65 PDE8Bphosphodiesterase 8B (ENSG00000113231), score: 0.65 PDYNprodynorphin (ENSG00000101327), score: 0.8 PLD3phospholipase D family, member 3 (ENSG00000105223), score: 0.67 PLXNA4plexin A4 (ENSG00000221866), score: 0.81 PNOCprepronociceptin (ENSG00000168081), score: 0.71 PRDM11PR domain containing 11 (ENSG00000019485), score: 0.66 PRKG2protein kinase, cGMP-dependent, type II (ENSG00000138669), score: 0.7 PRLHRprolactin releasing hormone receptor (ENSG00000119973), score: 0.83 PROKR2prokineticin receptor 2 (ENSG00000101292), score: 0.96 PRRG3proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) (ENSG00000130032), score: 0.8 PTPRAprotein tyrosine phosphatase, receptor type, A (ENSG00000132670), score: 0.67 RAB3BRAB3B, member RAS oncogene family (ENSG00000169213), score: 0.7 RARS2arginyl-tRNA synthetase 2, mitochondrial (ENSG00000146282), score: -0.65 RASL10ARAS-like, family 10, member A (ENSG00000100276), score: 0.65 RGS4regulator of G-protein signaling 4 (ENSG00000117152), score: 0.65 RNF135ring finger protein 135 (ENSG00000181481), score: -0.66 RNF24ring finger protein 24 (ENSG00000101236), score: 0.71 RORBRAR-related orphan receptor B (ENSG00000198963), score: 0.68 RXFP3relaxin/insulin-like family peptide receptor 3 (ENSG00000182631), score: 0.9 SERPINB13serpin peptidase inhibitor, clade B (ovalbumin), member 13 (ENSG00000197641), score: 0.85 SGTBsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, beta (ENSG00000197860), score: 0.65 SH2D4BSH2 domain containing 4B (ENSG00000178217), score: 0.73 SH2D5SH2 domain containing 5 (ENSG00000189410), score: 0.68 SHC3SHC (Src homology 2 domain containing) transforming protein 3 (ENSG00000148082), score: 0.75 SLC10A4solute carrier family 10 (sodium/bile acid cotransporter family), member 4 (ENSG00000145248), score: 0.7 SLC13A4solute carrier family 13 (sodium/sulfate symporters), member 4 (ENSG00000164707), score: 0.73 SLC24A4solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (ENSG00000140090), score: 0.73 SLC35D3solute carrier family 35, member D3 (ENSG00000182747), score: 0.65 SLC35E4solute carrier family 35, member E4 (ENSG00000100036), score: 0.66 SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 (ENSG00000011083), score: 0.65 SLC7A3solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 (ENSG00000165349), score: 0.88 SLC8A3solute carrier family 8 (sodium/calcium exchanger), member 3 (ENSG00000100678), score: 0.67 SLIT1slit homolog 1 (Drosophila) (ENSG00000187122), score: 0.74 SLITRK1SLIT and NTRK-like family, member 1 (ENSG00000178235), score: 0.68 SPRED3sprouty-related, EVH1 domain containing 3 (ENSG00000188766), score: 0.79 SSTsomatostatin (ENSG00000157005), score: 0.7 ST6GALNAC5ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ENSG00000117069), score: 0.75 STYK1serine/threonine/tyrosine kinase 1 (ENSG00000060140), score: 0.71 SYNGAP1synaptic Ras GTPase activating protein 1 (ENSG00000197283), score: 0.66 SYT6synaptotagmin VI (ENSG00000134207), score: 0.66 TACR1tachykinin receptor 1 (ENSG00000115353), score: 0.71 TBR1T-box, brain, 1 (ENSG00000136535), score: 0.68 TCEB3transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) (ENSG00000011007), score: -0.64 TMEM132Dtransmembrane protein 132D (ENSG00000151952), score: 0.74 TMEM155transmembrane protein 155 (ENSG00000164112), score: 0.65 TMEM179transmembrane protein 179 (ENSG00000189203), score: 0.67 TMEM200Atransmembrane protein 200A (ENSG00000164484), score: 0.67 TRAPPC10trafficking protein particle complex 10 (ENSG00000160218), score: 0.71 TRHRthyrotropin-releasing hormone receptor (ENSG00000174417), score: 0.96 TRPC5transient receptor potential cation channel, subfamily C, member 5 (ENSG00000072315), score: 0.73 TSHZ3teashirt zinc finger homeobox 3 (ENSG00000121297), score: 0.69 UNC5Dunc-5 homolog D (C. elegans) (ENSG00000156687), score: 0.66 VIPvasoactive intestinal peptide (ENSG00000146469), score: 0.7 VSTM2AV-set and transmembrane domain containing 2A (ENSG00000170419), score: 0.69 VWC2Lvon Willebrand factor C domain-containing protein 2-like (ENSG00000174453), score: 0.79 WDR7WD repeat domain 7 (ENSG00000091157), score: 0.65 WNT1wingless-type MMTV integration site family, member 1 (ENSG00000125084), score: 0.67 WNT10Bwingless-type MMTV integration site family, member 10B (ENSG00000169884), score: 0.66 WNT16wingless-type MMTV integration site family, member 16 (ENSG00000002745), score: 0.87 WNT7Awingless-type MMTV integration site family, member 7A (ENSG00000154764), score: 0.67 XKR4XK, Kell blood group complex subunit-related family, member 4 (ENSG00000206579), score: 0.8 XYLT1xylosyltransferase I (ENSG00000103489), score: 0.71 ZDHHC22zinc finger, DHHC-type containing 22 (ENSG00000177108), score: 0.66 ZNF831zinc finger protein 831 (ENSG00000124203), score: 0.94

Non-Entrez genes

ENSG00000181481Unknown, score: 1 ENSG00000100036Unknown, score: 0.65 ENSG00000133265Unknown, score: 0.7

Id	species	tissue	sex	individual
hsa_br_m3_ca1	hsa	br	m	3
ppy_br_f_ca1	ppy	br	f	_
hsa_br_m7_ca1	hsa	br	m	7
mml_br_m1_ca1	mml	br	m	1
mml_br_f_ca1	mml	br	f	_
ppy_br_m_ca1	ppy	br	m	_
mml_br_m2_ca1	mml	br	m	2