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skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

regionalization

The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

renal system process

A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism.

regulation of diuresis

Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion.

renal water homeostasis

Renal process involved in the maintenance of internal steady-state of water in the body.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

response to nutrient

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

body fluid secretion

The controlled release of a fluid by a cell or group of cells in a multicellular organism.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

anterior/posterior pattern formation

The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to extracellular stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

signaling pathway

The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.

intracellular signaling pathway

The series of molecular events whereby information is sent from one location to another within a cell.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

water homeostasis

Any process involved in the maintenance of an internal steady-state of water within an organism or cell.

diuresis

The process of renal water excretion.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

intracellular receptor mediated signaling pathway

Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.

epithelial cell differentiation

The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

response to nutrient levels

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

cellular response to nutrient levels

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

cellular response to nutrient

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

regulation of homeostatic process

Any process that modulates the frequency, rate, or extent of a homeostatic process.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

response to vitamin

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

response to vitamin D

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

regulation of excretion

Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

multicellular organismal water homeostasis

Any process involved in the maintenance of an internal steady-state of water within a tissue, organ, or a multicellular organism.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of secretion

Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.

regulation of transport

Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

epithelium development

The process whose specific outcome is the progression of an epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

vitamin D receptor signaling pathway

The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.

cellular response to chemical stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

cellular response to vitamin

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

cellular response to vitamin D

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

cellular response to external stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

all

NA

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

cellular response to chemical stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

regulation of transport

Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

diuresis

The process of renal water excretion.

regulation of excretion

Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

diuresis

The process of renal water excretion.

renal water homeostasis

Renal process involved in the maintenance of internal steady-state of water in the body.

tissue development

The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

cellular response to extracellular stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

cellular response to nutrient

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

body fluid secretion

The controlled release of a fluid by a cell or group of cells in a multicellular organism.

regulation of secretion

Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.

regulation of homeostatic process

Any process that modulates the frequency, rate, or extent of a homeostatic process.

cellular response to nutrient

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

diuresis

The process of renal water excretion.

regulation of diuresis

Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion.

regulation of diuresis

Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion.

epithelial cell differentiation

The process whereby a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.

regulation of excretion

Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.

response to nutrient

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.

cellular response to nutrient levels

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

cellular response to vitamin

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin stimulus.

cellular response to vitamin D

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

multicellular organismal water homeostasis

Any process involved in the maintenance of an internal steady-state of water within a tissue, organ, or a multicellular organism.

vitamin D receptor signaling pathway

The series of molecular signals generated as a consequence of a vitamin D receptor binding to one of its physiological ligands.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

brush border

Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

nucleic acid binding

Interacting selectively and non-covalently with any nucleic acid.

DNA binding

Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

anion transmembrane transporter activity

Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

inorganic anion transmembrane transporter activity

Catalysis of the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

anion:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).

antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:solute antiporter activity

Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

cation:chloride symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).

anion exchanger activity

NA

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

sequence-specific DNA binding

Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

solute:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).

anion:cation symporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006811	7.034e-08	9.708	33 ABCC4, AQP2, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, CLDN16, CSN2, CYP27B1, EGF, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC26A7, SLC34A1, SLC38A8, SLC4A1, SLC5A12, SLC5A8, SLC9A4, SLCO4C1, TCN2, TRPM6, TRPV4, VDR	663	ion transport
GO:0006812	8.689e-07	6.999	26 AQP2, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, CSN2, CYP27B1, EGF, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC22A13, SLC22A2, SLC22A4, SLC34A1, SLC38A8, SLC5A12, SLC5A8, SLC9A4, TCN2, TRPM6, TRPV4, VDR	478	cation transport
GO:0055085	1.062e-05	8.595	27 ABCC4, AQP2, AQP6, ATP6V0A4, ATP6V0D2, EGF, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC23A3, SLC26A7, SLC5A12, SLC5A8, SLC7A13, SLC9A4, TRPM6, TRPV4	587	transmembrane transport
GO:0006810	2.781e-05	32.59	60 ABCC4, AFP, AQP2, AQP6, ARSB, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, BTC, CD3G, CLDN16, CSN2, CUBN, CYP27B1, EGF, GAL, KCNJ1, NRG1, OXT, PRLR, RAB19, RAB7L1, SCTR, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC23A3, SLC26A7, SLC34A1, SLC35F2, SLC38A8, SLC4A1, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4, SLCO4C1, STRA6, TCN2, TNFSF15, TRPM6, TRPV4, UCN3, VDR	2226	transport
GO:0007588	3.445e-05	0.6882	8 AQP2, AQP6, ATP6V0A4, BTC, CLDN16, KCNJ1, OXT, SCTR	47	excretion
GO:0051179	3.975e-05	37.97	66 ABCC4, AFP, AGTR2, ALOX12, AQP2, AQP6, ARSB, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, BTC, CD3G, CLDN16, CSN2, CUBN, CYP27B1, EGF, F2RL1, GAL, IL12B, KCNJ1, NRG1, OXT, PARD6B, PKHD1, PRLR, RAB19, RAB7L1, SCTR, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC23A3, SLC26A7, SLC34A1, SLC35F2, SLC38A8, SLC4A1, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4, SLCO4C1, STRA6, TCN2, TNFSF15, TRPM6, TRPV4, UCN3, VDR	2593	localization
GO:0051234	4.040e-05	32.97	60 ABCC4, AFP, AQP2, AQP6, ARSB, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, BTC, CD3G, CLDN16, CSN2, CUBN, CYP27B1, EGF, GAL, KCNJ1, NRG1, OXT, PRLR, RAB19, RAB7L1, SCTR, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC23A3, SLC26A7, SLC34A1, SLC35F2, SLC38A8, SLC4A1, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4, SLCO4C1, STRA6, TCN2, TNFSF15, TRPM6, TRPV4, UCN3, VDR	2252	establishment of localization
GO:0030001	1.695e-04	6.003	20 AQP2, ATP12A, CSN2, CYP27B1, EGF, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC22A4, SLC34A1, SLC38A8, SLC5A12, SLC5A8, SLC9A4, TCN2, TRPM6, TRPV4, VDR	410	metal ion transport
GO:0015672	3.295e-04	3.719	15 ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC22A4, SLC34A1, SLC38A8, SLC5A12, SLC5A8, SLC9A4	254	monovalent inorganic cation transport
GO:0006814	5.386e-04	1.713	10 SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC22A4, SLC34A1, SLC38A8, SLC5A12, SLC5A8, SLC9A4	117	sodium ion transport
GO:0032501	5.652e-04	48.32	74 AFP, AGTR2, ALOX12, AQP2, AQP6, ARSB, ATP6V0A4, BTC, CALCR, CASR, CLDN16, CLDN19, COCH, COL19A1, CUBN, CYP24A1, CYP27B1, EGF, ELF5, F2RL1, FOXI1, FOXN1, GAL, GCM1, HMX2, HOXA10, HOXA2, HOXA9, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4, HSD11B2, HTR1D, IL12B, INSRR, KCNJ1, KL, KRT3, MATN3, MMP13, MYO3B, NHS, NOX4, NRG1, NTRK1, OR10Q1, OR51E1, OXT, PAQR5, PARD6B, PAX2, PKHD1, PRLR, REN, SCTR, SIM1, SLC12A6, SLC22A2, SLC22A4, SLC34A1, SLC6A4, SLCO4C1, SOX14, TBX19, TFCP2L1, TINAG, TNFSF15, UCMA, UPK2, VDR	3300	multicellular organismal process
GO:0070561	7.851e-04	0.05857	3 CYP24A1, CYP27B1, VDR	4	vitamin D receptor signaling pathway
GO:0071305	7.851e-04	0.05857	3 CYP24A1, CYP27B1, VDR	4	cellular response to vitamin D
GO:0046903	1.187e-03	5.828	18 AQP2, AQP6, ATP6V0A4, BTC, CLDN16, EGF, GAL, KCNJ1, NRG1, OXT, PRLR, SCTR, SLC22A2, SLC22A4, TNFSF15, TRPV4, UCN3, VDR	398	secretion
GO:0009952	2.524e-03	1.699	9 HOXA10, HOXA2, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4	116	anterior/posterior pattern formation
GO:0003014	2.837e-03	0.4246	5 AGTR2, AQP2, BTC, HSD11B2, OXT	29	renal system process
GO:0001501	4.721e-03	3.265	12 COL19A1, HOXA10, HOXA2, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4, MATN3, VDR	223	skeletal system development
GO:0007589	6.167e-03	0.8053	6 BTC, OXT, PRLR, SLC22A2, SLC22A4, VDR	55	body fluid secretion
GO:0030855	7.006e-03	1.991	9 ALOX12, CYP27B1, ELF5, FOXN1, HOXB5, KRT3, PAX2, TFCP2L1, UPK2	136	epithelial cell differentiation
GO:0042592	8.238e-03	9.576	22 ALOX12, AQP2, ATP6V0A4, BTC, CALCR, CASR, CCL23, CLDN16, CUBN, CYP27B1, F2RL1, GYLTL1B, HOXB6, NOX4, OXT, PKHD1, SLC22A12, SLC34A1, SLC4A1, SLC9A4, TRPV4, VDR	654	homeostatic process
GO:0003074	8.535e-03	0.02928	2 BTC, OXT	2	regulation of diuresis
GO:0001503	1.071e-02	2.138	9 ATP6V0A4, CALCR, CASR, CYP24A1, CYP27B1, HOXA2, KL, OXT, UCMA	146	ossification
GO:0048731	1.168e-02	29.17	47 AFP, AGTR2, ALOX12, AQP6, ARSB, CALCR, COL19A1, CYP27B1, EGF, ELF5, FOXI1, FOXN1, GAL, GCM1, HMX2, HOXA10, HOXA2, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4, IL12B, KL, KRT3, MATN3, NHS, NOX4, NRG1, NTRK1, OXT, PARD6B, PAX2, PKHD1, PRLR, REN, SIM1, SLC12A6, SLC6A4, SOX14, TBX19, TFCP2L1, TINAG, UPK2, VDR	1992	system development
GO:0007565	1.294e-02	1.332	7 AQP2, CYP27B1, HSD11B2, OXT, PRLR, TFCP2L1, VDR	91	female pregnancy
GO:0032502	1.338e-02	38.01	57 AFP, AGTR2, ALOX12, AQP2, AQP6, ARSB, BTC, CALCR, CASR, COL19A1, CUBN, CYP24A1, CYP27B1, EGF, ELF5, FOXI1, FOXN1, GAL, GCM1, HMX2, HOXA10, HOXA2, HOXA9, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4, IL12B, INSRR, KL, KRT3, MATN3, NHS, NOX4, NRG1, NTRK1, OXT, PAQR5, PARD6B, PAX2, PKHD1, PRLR, REN, SIM1, SLC12A6, SLC6A4, SLCO4C1, SOX14, TBX19, TFCP2L1, TINAG, UCMA, UPK2, VDR	2596	developmental process
GO:0065008	1.575e-02	19.83	35 AFP, AGTR2, ALOX12, AQP2, ATP6V0A4, BTC, CALCR, CASR, CCL23, CLDN16, CUBN, CYP27B1, ESM1, F2RL1, GAL, GYLTL1B, HOXB6, HSD11B2, NET1, NOX4, NRG1, OXT, PKHD1, PRLR, REN, SLC22A12, SLC22A2, SLC22A4, SLC34A1, SLC4A1, SLC6A4, SLC9A4, TRPV4, UCN3, VDR	1354	regulation of biological quality
GO:0003071	1.577e-02	0.1611	3 AGTR2, AQP2, HSD11B2	11	renal system process involved in regulation of systemic arterial blood pressure
GO:0048706	1.668e-02	1.01	6 HOXA2, HOXB5, HOXB6, HOXC6, HOXD10, HOXD4	69	embryonic skeletal system development
GO:0050878	1.892e-02	2.357	9 AQP2, BTC, F2RL1, HSD11B2, OXT, PRLR, SLC22A2, SLC22A4, VDR	161	regulation of body fluid levels
GO:0006972	1.962e-02	0.1757	3 AQP2, OXT, TRPV4	12	hyperosmotic response
GO:0010979	2.008e-02	0.04393	2 CYP27B1, VDR	3	regulation of vitamin D 24-hydroxylase activity
GO:0010980	2.008e-02	0.04393	2 CYP27B1, VDR	3	positive regulation of vitamin D 24-hydroxylase activity
GO:0031667	2.041e-02	2.899	10 AQP2, ARSB, CUBN, CYP24A1, CYP27B1, HSD11B2, OXT, SLC6A19, UCN3, VDR	198	response to nutrient levels
GO:0048704	2.041e-02	0.7028	5 HOXA2, HOXB5, HOXB6, HOXD10, HOXD4	48	embryonic skeletal system morphogenesis
GO:0050801	2.190e-02	5.213	14 ALOX12, ATP6V0A4, CALCR, CASR, CCL23, CLDN16, CYP27B1, F2RL1, OXT, SLC34A1, SLC4A1, SLC9A4, TRPV4, VDR	356	ion homeostasis
GO:0009651	2.350e-02	0.1903	3 AQP2, OXT, TRPV4	13	response to salt stress
GO:0015849	2.393e-02	1.977	8 OXT, SLC16A4, SLC22A12, SLC22A4, SLC26A7, SLC38A8, SLC6A19, SLC7A13	135	organic acid transport
GO:0048513	2.535e-02	22.14	37 AFP, AGTR2, ALOX12, AQP6, CALCR, COL19A1, CYP27B1, EGF, ELF5, FOXI1, FOXN1, GCM1, HMX2, HOXA2, HOXB5, HOXB6, HOXC8, HOXD10, HOXD4, IL12B, KL, KRT3, NHS, NOX4, NRG1, NTRK1, OXT, PAX2, PKHD1, PRLR, REN, SLC12A6, SLC6A4, TBX19, TFCP2L1, UPK2, VDR	1512	organ development
GO:0006820	2.563e-02	1.127	6 SLC13A1, SLC22A11, SLC22A12, SLC26A7, SLC34A1, SLC4A1	77	anion transport
GO:0007275	2.701e-02	34.94	52 AFP, AGTR2, ALOX12, AQP6, ARSB, CALCR, COL19A1, CUBN, CYP27B1, EGF, ELF5, FOXI1, FOXN1, GAL, GCM1, HMX2, HOXA10, HOXA2, HOXA9, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4, IL12B, INSRR, KL, KRT3, MATN3, NHS, NOX4, NRG1, NTRK1, OXT, PAQR5, PARD6B, PAX2, PKHD1, PRLR, REN, SIM1, SLC12A6, SLC6A4, SLCO4C1, SOX14, TBX19, TFCP2L1, TINAG, UPK2, VDR	2386	multicellular organismal development
GO:0006970	2.801e-02	0.4539	4 AQP2, FMO1, OXT, TRPV4	31	response to osmotic stress
GO:0055080	2.819e-02	3.631	11 ATP6V0A4, CALCR, CASR, CCL23, CLDN16, CYP27B1, F2RL1, OXT, SLC9A4, TRPV4, VDR	248	cation homeostasis
GO:0048856	2.869e-02	31.58	48 AFP, AGTR2, ALOX12, AQP6, ARSB, CALCR, CASR, COL19A1, CYP27B1, EGF, ELF5, FOXI1, FOXN1, GAL, GCM1, HMX2, HOXA10, HOXA2, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4, IL12B, KL, KRT3, MATN3, NHS, NOX4, NRG1, NTRK1, OXT, PARD6B, PAX2, PKHD1, PRLR, REN, SIM1, SLC12A6, SLC6A4, SOX14, TBX19, TFCP2L1, TINAG, UPK2, VDR	2157	anatomical structure development
GO:0009991	3.030e-02	3.119	10 AQP2, ARSB, CUBN, CYP24A1, CYP27B1, HSD11B2, OXT, SLC6A19, UCN3, VDR	213	response to extracellular stimulus
GO:0003002	3.062e-02	2.592	9 HOXA10, HOXA2, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4	177	regionalization
GO:0048562	3.142e-02	1.625	7 FOXI1, HMX2, HOXA2, HOXB5, HOXB6, HOXD10, HOXD4	111	embryonic organ morphogenesis
GO:0015889	3.248e-02	0.05857	2 CUBN, TCN2	4	cobalamin transport
GO:0055065	3.519e-02	2.665	9 CALCR, CASR, CCL23, CLDN16, CYP27B1, F2RL1, OXT, TRPV4, VDR	182	metal ion homeostasis
GO:0016338	3.701e-02	0.2343	3 CLDN16, CLDN19, CLDN8	16	calcium-independent cell-cell adhesion
GO:0033280	3.701e-02	0.2343	3 CYP24A1, CYP27B1, VDR	16	response to vitamin D
GO:0003073	4.567e-02	0.5418	4 AGTR2, AQP2, HSD11B2, REN	37	regulation of systemic arterial blood pressure
GO:0007171	4.667e-02	0.07321	2 NRG1, PRLR	5	activation of transmembrane receptor protein tyrosine kinase activity
GO:0021520	4.667e-02	0.07321	2 HOXC10, HOXD10	5	spinal cord motor neuron cell fate specification
GO:0042538	4.667e-02	0.07321	2 OXT, TRPV4	5	hyperosmotic salinity response
GO:0048878	4.937e-02	6.53	15 ALOX12, ATP6V0A4, BTC, CALCR, CASR, CCL23, CLDN16, CYP27B1, F2RL1, OXT, SLC34A1, SLC4A1, SLC9A4, TRPV4, VDR	446	chemical homeostasis

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	5.283e-10	2.527	19 AQP2, ATP6V0A4, ATP6V0D2, CUBN, NRG1, PARD6B, PKHD1, PROM2, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC22A4, SLC4A9, SLC5A12, SLC5A8, SLC9A4, TRPM6, UMOD	170	apical part of cell
GO:0016324	1.009e-09	2.007	17 AQP2, ATP6V0A4, ATP6V0D2, CUBN, NRG1, PKHD1, PROM2, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC22A4, SLC5A12, SLC5A8, SLC9A4, TRPM6, UMOD	135	apical plasma membrane
GO:0005886	2.025e-09	39.01	78 ABCC4, AGTR2, ALOX12, AQP2, AQP6, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, BSND, BTC, CALCR, CASR, CD3G, CDCP1, CDH16, CLDN16, CLDN19, CLDN24, CLDN8, CUBN, EGF, F2RL1, FGFBP1, GFRAL, GP2, GPR110, GPRC6A, HTR1D, INSRR, KCNJ1, KL, NOX4, NRG1, NTRK1, OR10Q1, OR51E1, OXGR1, PARD6B, PKHD1, PLA2G3, PROM2, RAB19, RAB7L1, SCTR, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC26A7, SLC34A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC9A4, SLCO4C1, STRA6, TAAR2, THEM4, TNFSF15, TRPM6, TRPV4, UMOD, UPK2, XPNPEP2	2624	plasma membrane
GO:0044459	2.333e-07	23.67	53 AGTR2, AQP2, AQP6, ATP12A, ATP6V0A4, ATP6V0D2, BSND, CALCR, CASR, CD3G, CLDN16, CLDN19, CLDN24, CLDN8, CUBN, F2RL1, HTR1D, INSRR, KCNJ1, KL, NOX4, NRG1, NTRK1, PARD6B, PKHD1, PROM2, SCTR, SLC12A1, SLC12A3, SLC12A6, SLC15A2, SLC16A4, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC26A7, SLC34A1, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC9A4, SLCO4C1, THEM4, TNFSF15, TRPM6, TRPV4, UMOD, UPK2	1592	plasma membrane part
GO:0031224	1.041e-06	55.26	90 ABCC4, AGTR2, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, BSND, BTC, C12orf59, C17orf78, CALCR, CASR, CD164L2, CD3G, CDCP1, CDH16, CLDN16, CLDN19, CLDN24, CLDN8, EGF, F2RL1, FMO1, GFRAL, GP2, GPR110, GPRC6A, GYLTL1B, HTR1D, INSRR, KCNJ1, KL, LRRC19, MS4A10, MSLNL, NOX4, NRG1, NTRK1, OR10Q1, OR51E1, OXGR1, PAQR5, PKHD1, PRLR, PROM2, PTPLAD2, SCTR, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC23A3, SLC26A7, SLC34A1, SLC35F2, SLC38A8, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4, SLCO4C1, STRA6, TAAR2, TMEM27, TMEM72, TMIGD1, TMPRSS13, TNFSF15, TRPM6, TRPV4, UMOD, UPK2, XPNPEP2	3717	intrinsic to membrane
GO:0016021	3.964e-06	54.08	87 ABCC4, AGTR2, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, BSND, BTC, C12orf59, C17orf78, CALCR, CASR, CD164L2, CD3G, CDCP1, CDH16, CLDN16, CLDN19, CLDN24, CLDN8, EGF, F2RL1, FMO1, GFRAL, GPR110, GPRC6A, GYLTL1B, HTR1D, INSRR, KCNJ1, KL, LRRC19, MS4A10, MSLNL, NOX4, NRG1, NTRK1, OR10Q1, OR51E1, OXGR1, PAQR5, PKHD1, PRLR, PROM2, PTPLAD2, SCTR, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC23A3, SLC26A7, SLC34A1, SLC35F2, SLC38A8, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4, SLCO4C1, STRA6, TAAR2, TMEM27, TMEM72, TMIGD1, TMPRSS13, TNFSF15, TRPM6, TRPV4, UPK2	3638	integral to membrane
GO:0044425	2.354e-05	63.73	95 ABCC4, AGTR2, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, BSND, BTC, C12orf59, C17orf78, CALCR, CASR, CD164L2, CD3G, CDCP1, CDH16, CLDN16, CLDN19, CLDN24, CLDN8, CUBN, EGF, F2RL1, FMO1, GFRAL, GP2, GPR110, GPRC6A, GYLTL1B, HTR1D, INSRR, KCNJ1, KL, LRRC19, MS4A10, MSLNL, NOX4, NRG1, NTRK1, OR10Q1, OR51E1, OXGR1, PAQR5, PARD6B, PKHD1, PRLR, PROM2, PTPLAD2, SCTR, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC23A3, SLC26A7, SLC34A1, SLC35F2, SLC38A8, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4, SLCO4C1, STRA6, TAAR2, THEM4, TMEM27, TMEM72, TMIGD1, TMPRSS13, TNFSF15, TRPM6, TRPV4, UMOD, UPK2, XPNPEP2	4287	membrane part
GO:0016020	1.859e-04	76.53	105 ABCC4, AGTR2, ALOX12, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, BSND, BTC, C12orf59, C17orf78, CALCR, CASR, CD164L2, CD3G, CDCP1, CDH16, CLDN16, CLDN19, CLDN24, CLDN8, CUBN, CYP24A1, CYP27B1, EGF, F2RL1, FGFBP1, FMO1, GFRAL, GP2, GPR110, GPRC6A, GYLTL1B, HTR1D, IL12B, INSRR, KCNJ1, KL, LRRC19, MS4A10, MSLNL, NOX4, NRG1, NTRK1, OR10Q1, OR51E1, OXGR1, PAQR5, PARD6B, PKHD1, PLA2G3, PRLR, PROM2, PTPLAD2, RAB19, RAB7L1, REN, SCTR, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC23A3, SLC26A7, SLC34A1, SLC35F2, SLC38A8, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4, SLCO4C1, STRA6, TAAR2, TFCP2L1, THEM4, TMEM27, TMEM72, TMIGD1, TMPRSS13, TNFSF15, TRPM6, TRPV4, UMOD, UPK2, XPNPEP2	5148	membrane
GO:0005903	3.197e-04	0.5352	6 ATP6V0A4, CUBN, SLC13A1, SLC22A12, SLC34A1, TRPM6	36	brush border
GO:0031526	5.233e-04	0.3568	5 ATP6V0A4, CUBN, SLC22A12, SLC34A1, TRPM6	24	brush border membrane
GO:0016471	2.005e-03	0.1041	3 ATP6V0A4, ATP6V0D2, ATP6V1G3	7	vacuolar proton-transporting V-type ATPase complex
GO:0016323	2.453e-03	2.854	11 AQP2, BSND, CLDN19, NOX4, PROM2, SLC12A6, SLC26A7, SLC4A1, SLC4A9, SLC9A4, SLCO4C1	192	basolateral plasma membrane
GO:0031226	4.985e-03	14.03	28 AGTR2, AQP6, ATP12A, BSND, CALCR, CASR, CD3G, F2RL1, HTR1D, INSRR, KCNJ1, KL, NTRK1, PKHD1, SCTR, SLC12A3, SLC15A2, SLC16A4, SLC22A11, SLC22A13, SLC22A2, SLC22A4, SLC34A1, SLC4A1, SLC6A19, SLC6A4, TNFSF15, UPK2	944	intrinsic to plasma membrane
GO:0031253	6.208e-03	1.353	7 ATP6V0A4, CUBN, PROM2, SLC22A12, SLC34A1, THEM4, TRPM6	91	cell projection membrane
GO:0005887	7.666e-03	13.74	27 AGTR2, AQP6, ATP12A, BSND, CALCR, CASR, CD3G, F2RL1, HTR1D, INSRR, KCNJ1, KL, NTRK1, SCTR, SLC12A3, SLC15A2, SLC16A4, SLC22A11, SLC22A13, SLC22A2, SLC22A4, SLC34A1, SLC4A1, SLC6A19, SLC6A4, TNFSF15, UPK2	924	integral to plasma membrane
GO:0033176	1.643e-02	0.223	3 ATP6V0A4, ATP6V0D2, ATP6V1G3	15	proton-transporting V-type ATPase complex
GO:0005923	1.664e-02	0.8177	5 CLDN16, CLDN19, CLDN24, CLDN8, PARD6B	55	tight junction
GO:0070160	1.664e-02	0.8177	5 CLDN16, CLDN19, CLDN24, CLDN8, PARD6B	55	occluding junction
GO:0044421	1.753e-02	10.99	22 AFP, BTC, CCL23, COCH, COL19A1, COL4A6, EGF, FGFBP1, IL12B, KL, LAMB4, MATN3, MMP13, NRG1, OXT, PAPLN, PLA2G3, REN, TCN2, TINAG, TNFSF15, UCMA	739	extracellular region part
GO:0005576	1.754e-02	20.92	35 AFP, AGR3, ARSF, BTC, CCL23, CDCP1, COCH, COL19A1, COL4A6, CSN2, DEFB4A, EGF, ESM1, FGFBP1, GAL, GKN2, GP2, IGFL3, IL12B, KL, LAMB4, MATN3, MMP13, NRG1, OXT, PAPLN, PLA2G3, PRLR, REN, TCN2, TINAG, TNFSF15, UCMA, UCN3, UMOD	1407	extracellular region
GO:0043296	3.074e-02	0.9663	5 CLDN16, CLDN19, CLDN24, CLDN8, PARD6B	65	apical junction complex
GO:0016327	3.617e-02	1.011	5 CLDN16, CLDN19, CLDN24, CLDN8, PARD6B	68	apicolateral plasma membrane
GO:0044463	4.176e-02	4.311	11 ATP6V0A4, CALCR, CUBN, OXT, PKHD1, PROM2, SLC22A12, SLC34A1, THEM4, TRPM6, UCN3	290	cell projection part

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022804	8.448e-13	3.898	27 ABCC4, ATP10D, ATP12A, ATP6V0A4, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A4, SLC26A7, SLC34A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4	277	active transmembrane transporter activity
GO:0015291	3.507e-12	2.251	21 SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A4, SLC26A7, SLC34A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC9A4	160	secondary active transmembrane transporter activity
GO:0022857	3.152e-11	10.02	39 ABCC4, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, BSND, CLDN16, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC26A7, SLC34A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4, TRPM6, TRPV4	712	transmembrane transporter activity
GO:0005215	1.697e-10	12.83	43 ABCC4, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1G3, BSND, CLDN16, CSN2, CUBN, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC23A3, SLC26A7, SLC34A1, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC6A4, SLC7A13, SLC9A4, SLCO4C1, TRPM6, TRPV4	912	transporter activity
GO:0015293	3.979e-09	1.506	15 SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC15A5, SLC16A12, SLC16A4, SLC16A9, SLC22A4, SLC34A1, SLC5A12, SLC5A8, SLC6A19, SLC6A4	107	symporter activity
GO:0022891	4.547e-08	9.132	32 ABCC4, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, BSND, CLDN16, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC16A4, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC26A7, SLC34A1, SLC4A1, SLC4A9, SLC6A19, SLC6A4, SLC7A13, SLC9A4, TRPM6, TRPV4	649	substrate-specific transmembrane transporter activity
GO:0022892	1.364e-06	10.61	32 ABCC4, AQP2, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, BSND, CLDN16, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC16A4, SLC18A1, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A4, SLC26A7, SLC34A1, SLC4A1, SLC4A9, SLC6A19, SLC6A4, SLC7A13, SLC9A4, TRPM6, TRPV4	754	substrate-specific transporter activity
GO:0015075	1.909e-06	7.95	27 ABCC4, AQP6, ATP10D, ATP12A, ATP6V0A4, ATP6V0D2, BSND, CLDN16, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC22A11, SLC22A13, SLC22A2, SLC22A4, SLC26A7, SLC34A1, SLC4A1, SLC4A9, SLC6A19, SLC6A4, SLC9A4, TRPM6, TRPV4	565	ion transmembrane transporter activity
GO:0008509	8.141e-06	1.66	12 ABCC4, AQP6, BSND, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC22A11, SLC26A7, SLC34A1, SLC4A1, SLC4A9	118	anion transmembrane transporter activity
GO:0015297	5.020e-04	0.7599	7 SLC22A11, SLC22A4, SLC26A7, SLC47A2, SLC4A1, SLC4A9, SLC9A4	54	antiporter activity
GO:0015300	1.122e-03	0.591	6 SLC22A11, SLC22A4, SLC26A7, SLC4A1, SLC4A9, SLC9A4	42	solute:solute antiporter activity
GO:0008324	1.770e-03	6.149	18 ATP12A, ATP6V0A4, ATP6V0D2, CLDN16, KCNJ1, SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC22A13, SLC22A2, SLC22A4, SLC6A19, SLC6A4, SLC9A4, TRPM6, TRPV4	437	cation transmembrane transporter activity
GO:0015380	2.434e-03	0.2251	4 SLC22A11, SLC26A7, SLC4A1, SLC4A9	16	anion exchanger activity
GO:0015103	2.614e-03	0.4362	5 AQP6, SLC13A1, SLC26A7, SLC34A1, SLC4A1	31	inorganic anion transmembrane transporter activity
GO:0015294	2.803e-03	1.027	7 SLC12A1, SLC12A3, SLC12A6, SLC13A1, SLC15A2, SLC6A19, SLC6A4	73	solute:cation symporter activity
GO:0015301	3.003e-03	0.2392	4 SLC22A11, SLC26A7, SLC4A1, SLC4A9	17	anion:anion antiporter activity
GO:0043565	3.083e-03	6.473	18 ELF5, FOXI1, FOXN1, HMX2, HNF4G, HOXA10, HOXA2, HOXA9, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4, PAX2, SOX14, VDR	460	sequence-specific DNA binding
GO:0004872	4.035e-03	13.96	29 AGTR2, C1orf116, CALCR, CASR, CD3G, CUBN, F2RL1, GFRAL, GPR110, GPRC6A, HNF4G, HTR1D, IL12B, INSRR, MS4A10, NTRK1, OR10Q1, OR51E1, OXGR1, PAQR5, PKHD1, PRLR, SCTR, STRA6, TAAR2, TINAG, TMPRSS13, TRPV4, VDR	992	receptor activity
GO:0015377	5.066e-03	0.1126	3 SLC12A1, SLC12A3, SLC12A6	8	cation:chloride symporter activity
GO:0003700	1.068e-02	9.963	22 ELF5, FOXI1, FOXN1, GCM1, GRHL2, HMX2, HNF4G, HOXA10, HOXA2, HOXA9, HOXB5, HOXB6, HOXC10, HOXC6, HOXC8, HOXD10, HOXD4, SIM1, TBX19, TFCP2L1, TFEC, VDR	708	sequence-specific DNA binding transcription factor activity
GO:0004871	1.213e-02	18.91	34 AGTR2, C1orf116, CALCR, CASR, CD3G, CLNK, CUBN, EGF, F2RL1, GFRAL, GPR110, GPRC6A, HNF4G, HTR1D, IL12B, INSRR, KL, MS4A10, NRG1, NTRK1, OR10Q1, OR51E1, OXGR1, PAQR5, PKHD1, PRLR, SCTR, SIM1, STRA6, TAAR2, TINAG, TMPRSS13, TRPV4, VDR	1344	signal transducer activity
GO:0060089	1.213e-02	18.91	34 AGTR2, C1orf116, CALCR, CASR, CD3G, CLNK, CUBN, EGF, F2RL1, GFRAL, GPR110, GPRC6A, HNF4G, HTR1D, IL12B, INSRR, KL, MS4A10, NRG1, NTRK1, OR10Q1, OR51E1, OXGR1, PAQR5, PKHD1, PRLR, SCTR, SIM1, STRA6, TAAR2, TINAG, TMPRSS13, TRPV4, VDR	1344	molecular transducer activity
GO:0022890	1.447e-02	2.322	9 ATP12A, ATP6V0A4, ATP6V0D2, CLDN16, SLC13A1, SLC22A4, SLC6A19, SLC6A4, SLC9A4	165	inorganic cation transmembrane transporter activity
GO:0005452	1.482e-02	0.1689	3 SLC22A11, SLC4A1, SLC4A9	12	inorganic anion exchanger activity
GO:0015101	1.482e-02	0.1689	3 SLC22A13, SLC22A2, SLC22A4	12	organic cation transmembrane transporter activity
GO:0015238	1.482e-02	0.1689	3 SLC15A2, SLC18A1, SLC47A2	12	drug transmembrane transporter activity
GO:0015296	1.939e-02	0.4221	4 SLC12A1, SLC12A3, SLC12A6, SLC13A1	30	anion:cation symporter activity
GO:0030297	2.628e-02	0.05629	2 EGF, NRG1	4	transmembrane receptor protein tyrosine kinase activator activity
GO:0004888	3.073e-02	9.625	20 AGTR2, CALCR, CASR, CD3G, F2RL1, GPR110, GPRC6A, HTR1D, IL12B, INSRR, NTRK1, OR10Q1, OR51E1, OXGR1, PRLR, SCTR, TAAR2, TINAG, TMPRSS13, TRPV4	684	transmembrane receptor activity
GO:0016709	3.329e-02	0.2392	3 CYP24A1, CYP27B1, FMO1	17	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
GO:0005275	3.758e-02	0.8865	5 SLC18A1, SLC22A4, SLC6A19, SLC6A4, SLC7A13	63	amine transmembrane transporter activity
GO:0005326	3.794e-02	0.2533	3 SLC22A2, SLC6A19, SLC6A4	18	neurotransmitter transporter activity
GO:0008504	3.801e-02	0.07036	2 SLC18A1, SLC6A4	5	monoamine transmembrane transporter activity
GO:0015077	3.921e-02	1.773	7 ATP12A, ATP6V0A4, ATP6V0D2, SLC13A1, SLC6A19, SLC6A4, SLC9A4	126	monovalent inorganic cation transmembrane transporter activity
GO:0030545	4.312e-02	0.2674	3 AGTR2, EGF, NRG1	19	receptor regulator activity

Id	Pvalue	ExpCount	Count	Size	Term
04966	3.325e-03	0.2628	4 ATP6V0A4, ATP6V0D2, ATP6V1G3, SLC4A1	21	Collecting duct acid secretion

No enriched terms

No enriched terms

Entrez genes

A2LD1AIG2-like domain 1 (ENSG00000134864), score: 0.56 ABCC4ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ENSG00000125257), score: 0.53 AFPalpha-fetoprotein (ENSG00000081051), score: 0.58 AGR3anterior gradient homolog 3 (Xenopus laevis) (ENSG00000173467), score: 1 AGTR2angiotensin II receptor, type 2 (ENSG00000180772), score: 0.5 ALOX12arachidonate 12-lipoxygenase (ENSG00000108839), score: 0.5 AQP2aquaporin 2 (collecting duct) (ENSG00000167580), score: 0.49 AQP6aquaporin 6, kidney specific (ENSG00000086159), score: 0.54 ARSBarylsulfatase B (ENSG00000113273), score: 0.62 ARSFarylsulfatase F (ENSG00000062096), score: 0.53 ASPAaspartoacylase (ENSG00000108381), score: 0.53 ATP10DATPase, class V, type 10D (ENSG00000145246), score: 0.56 ATP12AATPase, H+/K+ transporting, nongastric, alpha polypeptide (ENSG00000075673), score: 0.63 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.51 ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (ENSG00000147614), score: 0.49 ATP6V1G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 (ENSG00000151418), score: 0.49 BSNDBartter syndrome, infantile, with sensorineural deafness (Barttin) (ENSG00000162399), score: 0.5 BTCbetacellulin (ENSG00000174808), score: 0.64 C12orf59chromosome 12 open reading frame 59 (ENSG00000165685), score: 0.51 C17orf78chromosome 17 open reading frame 78 (ENSG00000167230), score: 0.77 C1orf116chromosome 1 open reading frame 116 (ENSG00000182795), score: 0.57 C2orf54chromosome 2 open reading frame 54 (ENSG00000172478), score: 0.48 CA13carbonic anhydrase XIII (ENSG00000185015), score: 0.6 CALCRcalcitonin receptor (ENSG00000004948), score: 0.69 CAPN13calpain 13 (ENSG00000162949), score: 0.57 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.58 CCL23chemokine (C-C motif) ligand 23 (ENSG00000167236), score: 0.49 CD164L2CD164 sialomucin-like 2 (ENSG00000174950), score: 0.67 CD3GCD3g molecule, gamma (CD3-TCR complex) (ENSG00000160654), score: 0.49 CDCP1CUB domain containing protein 1 (ENSG00000163814), score: 0.52 CDH16cadherin 16, KSP-cadherin (ENSG00000166589), score: 0.48 CDKL1cyclin-dependent kinase-like 1 (CDC2-related kinase) (ENSG00000100490), score: 0.52 CLDN16claudin 16 (ENSG00000113946), score: 0.61 CLDN19claudin 19 (ENSG00000164007), score: 0.58 CLDN24claudin 24 (ENSG00000185758), score: 0.54 CLDN8claudin 8 (ENSG00000156284), score: 0.56 CLNKcytokine-dependent hematopoietic cell linker (ENSG00000109684), score: 0.49 COCHcoagulation factor C homolog, cochlin (Limulus polyphemus) (ENSG00000100473), score: 0.56 COL19A1collagen, type XIX, alpha 1 (ENSG00000082293), score: 0.56 COL4A6collagen, type IV, alpha 6 (ENSG00000197565), score: 0.54 CSN2casein beta (ENSG00000135222), score: 0.78 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.57 CYP24A1cytochrome P450, family 24, subfamily A, polypeptide 1 (ENSG00000019186), score: 0.52 CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 1 (ENSG00000111012), score: 0.52 DEFB4Bdefensin, beta 4B (ENSG00000171711), score: 0.94 DHDHdihydrodiol dehydrogenase (dimeric) (ENSG00000104808), score: 0.55 DOCK8dedicator of cytokinesis 8 (ENSG00000107099), score: 0.59 EGFepidermal growth factor (ENSG00000138798), score: 0.54 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.65 ESM1endothelial cell-specific molecule 1 (ENSG00000164283), score: 0.57 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.53 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.52 FAM83Bfamily with sequence similarity 83, member B (ENSG00000168143), score: 0.49 FAM83Cfamily with sequence similarity 83, member C (ENSG00000125998), score: 0.61 FGFBP1fibroblast growth factor binding protein 1 (ENSG00000137440), score: 0.63 FMO1flavin containing monooxygenase 1 (ENSG00000010932), score: 0.54 FOXI1forkhead box I1 (ENSG00000168269), score: 0.53 FOXN1forkhead box N1 (ENSG00000109101), score: 0.56 GALgalanin prepropeptide (ENSG00000069482), score: 0.52 GCM1glial cells missing homolog 1 (Drosophila) (ENSG00000137270), score: 0.58 GFRALGDNF family receptor alpha like (ENSG00000187871), score: 0.49 GKN2gastrokine 2 (ENSG00000183607), score: 0.5 GP2glycoprotein 2 (zymogen granule membrane) (ENSG00000169347), score: 0.65 GPR110G protein-coupled receptor 110 (ENSG00000153292), score: 0.51 GPRC6AG protein-coupled receptor, family C, group 6, member A (ENSG00000173612), score: 0.64 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.56 GYLTL1Bglycosyltransferase-like 1B (ENSG00000165905), score: 0.53 HMX2H6 family homeobox 2 (ENSG00000188816), score: 0.61 HNF4Ghepatocyte nuclear factor 4, gamma (ENSG00000164749), score: 0.51 HOXA10homeobox A10 (ENSG00000153807), score: 0.49 HOXA2homeobox A2 (ENSG00000105996), score: 0.52 HOXA9homeobox A9 (ENSG00000078399), score: 0.49 HOXB5homeobox B5 (ENSG00000120075), score: 0.51 HOXB6homeobox B6 (ENSG00000108511), score: 0.49 HOXC10homeobox C10 (ENSG00000180818), score: 0.51 HOXC6homeobox C6 (ENSG00000197757), score: 0.48 HOXC8homeobox C8 (ENSG00000037965), score: 0.48 HOXD10homeobox D10 (ENSG00000128710), score: 0.51 HOXD4homeobox D4 (ENSG00000170166), score: 0.51 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.53 HTR1D5-hydroxytryptamine (serotonin) receptor 1D (ENSG00000179546), score: 0.65 IGFL3IGF-like family member 3 (ENSG00000188624), score: 0.55 IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (ENSG00000113302), score: 0.74 INSRRinsulin receptor-related receptor (ENSG00000027644), score: 0.59 IVNS1ABPinfluenza virus NS1A binding protein (ENSG00000116679), score: 0.5 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.49 KIAA1609KIAA1609 (ENSG00000140950), score: 0.51 KLklotho (ENSG00000133116), score: 0.56 KRT3keratin 3 (ENSG00000186442), score: 0.79 LAMB4laminin, beta 4 (ENSG00000091128), score: 0.84 LRRC19leucine rich repeat containing 19 (ENSG00000184434), score: 0.62 MATN3matrilin 3 (ENSG00000132031), score: 0.54 MCCD1mitochondrial coiled-coil domain 1 (ENSG00000204511), score: 0.49 MCM10minichromosome maintenance complex component 10 (ENSG00000065328), score: 0.59 MIOXmyo-inositol oxygenase (ENSG00000100253), score: 0.49 MMP13matrix metallopeptidase 13 (collagenase 3) (ENSG00000137745), score: 0.61 MOBKL2BMOB1, Mps One Binder kinase activator-like 2B (yeast) (ENSG00000120162), score: 0.49 MS4A10membrane-spanning 4-domains, subfamily A, member 10 (ENSG00000172689), score: 0.65 MSLNLmesothelin-like (ENSG00000162006), score: 0.69 MTMR8myotubularin related protein 8 (ENSG00000102043), score: 0.69 MYO3Bmyosin IIIB (ENSG00000071909), score: 0.48 NARFnuclear prelamin A recognition factor (ENSG00000141562), score: -0.55 NET1neuroepithelial cell transforming 1 (ENSG00000173848), score: 0.52 NHSNance-Horan syndrome (congenital cataracts and dental anomalies) (ENSG00000188158), score: 0.53 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.51 NRG1neuregulin 1 (ENSG00000157168), score: 0.51 NTRK1neurotrophic tyrosine kinase, receptor, type 1 (ENSG00000198400), score: 0.57 OR10Q1olfactory receptor, family 10, subfamily Q, member 1 (ENSG00000180475), score: 0.72 OR51E1olfactory receptor, family 51, subfamily E, member 1 (ENSG00000180785), score: 0.62 OXGR1oxoglutarate (alpha-ketoglutarate) receptor 1 (ENSG00000165621), score: 0.65 OXToxytocin, prepropeptide (ENSG00000101405), score: 0.55 PAPLNpapilin, proteoglycan-like sulfated glycoprotein (ENSG00000100767), score: 0.54 PAQR5progestin and adipoQ receptor family member V (ENSG00000137819), score: 0.5 PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans) (ENSG00000124171), score: 0.55 PAX2paired box 2 (ENSG00000075891), score: 0.53 PKHD1polycystic kidney and hepatic disease 1 (autosomal recessive) (ENSG00000170927), score: 0.57 PLA2G3phospholipase A2, group III (ENSG00000100078), score: 0.87 PNPLA1patatin-like phospholipase domain containing 1 (ENSG00000180316), score: 0.74 PRLRprolactin receptor (ENSG00000113494), score: 0.61 PROM2prominin 2 (ENSG00000155066), score: 0.48 PTPLAD2protein tyrosine phosphatase-like A domain containing 2 (ENSG00000188921), score: 0.66 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.6 RAB7L1RAB7, member RAS oncogene family-like 1 (ENSG00000117280), score: 0.5 RENrenin (ENSG00000143839), score: 0.55 SCTRsecretin receptor (ENSG00000080293), score: 0.54 SIM1single-minded homolog 1 (Drosophila) (ENSG00000112246), score: 0.57 SLC12A1solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (ENSG00000074803), score: 0.53 SLC12A3solute carrier family 12 (sodium/chloride transporters), member 3 (ENSG00000070915), score: 0.53 SLC12A6solute carrier family 12 (potassium/chloride transporters), member 6 (ENSG00000140199), score: 0.52 SLC13A1solute carrier family 13 (sodium/sulfate symporters), member 1 (ENSG00000081800), score: 0.49 SLC15A2solute carrier family 15 (H+/peptide transporter), member 2 (ENSG00000163406), score: 0.49 SLC15A5solute carrier family 15, member 5 (ENSG00000188991), score: 0.87 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.48 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.53 SLC16A9solute carrier family 16, member 9 (monocarboxylic acid transporter 9) (ENSG00000165449), score: 0.58 SLC18A1solute carrier family 18 (vesicular monoamine), member 1 (ENSG00000036565), score: 0.56 SLC22A11solute carrier family 22 (organic anion/urate transporter), member 11 (ENSG00000168065), score: 0.5 SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12 (ENSG00000197891), score: 0.49 SLC22A13solute carrier family 22 (organic anion transporter), member 13 (ENSG00000172940), score: 0.54 SLC22A2solute carrier family 22 (organic cation transporter), member 2 (ENSG00000112499), score: 0.55 SLC22A4solute carrier family 22 (organic cation/ergothioneine transporter), member 4 (ENSG00000197208), score: 0.59 SLC23A3solute carrier family 23 (nucleobase transporters), member 3 (ENSG00000213901), score: 0.5 SLC26A7solute carrier family 26, member 7 (ENSG00000147606), score: 0.59 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.5 SLC35F2solute carrier family 35, member F2 (ENSG00000110660), score: 0.49 SLC38A8solute carrier family 38, member 8 (ENSG00000166558), score: 0.5 SLC47A2solute carrier family 47, member 2 (ENSG00000180638), score: 0.48 SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (ENSG00000004939), score: 0.48 SLC4A9solute carrier family 4, sodium bicarbonate cotransporter, member 9 (ENSG00000113073), score: 0.51 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.5 SLC5A8solute carrier family 5 (iodide transporter), member 8 (ENSG00000139357), score: 0.57 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.56 SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (ENSG00000108576), score: 0.69 SLC7A13solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 (ENSG00000164893), score: 0.68 SLC9A4solute carrier family 9 (sodium/hydrogen exchanger), member 4 (ENSG00000180251), score: 0.53 SLCO4C1solute carrier organic anion transporter family, member 4C1 (ENSG00000173930), score: 0.49 SOX14SRY (sex determining region Y)-box 14 (ENSG00000168875), score: 0.66 STRA6stimulated by retinoic acid gene 6 homolog (mouse) (ENSG00000137868), score: 0.51 TAAR2trace amine associated receptor 2 (ENSG00000146378), score: 0.58 TBX19T-box 19 (ENSG00000143178), score: 0.53 TCL1BT-cell leukemia/lymphoma 1B (ENSG00000213231), score: 0.55 TCN2transcobalamin II (ENSG00000185339), score: 0.5 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.5 TFECtranscription factor EC (ENSG00000105967), score: 0.72 THEM4thioesterase superfamily member 4 (ENSG00000159445), score: 0.49 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.54 TMEM27transmembrane protein 27 (ENSG00000147003), score: 0.49 TMEM72transmembrane protein 72 (ENSG00000187783), score: 0.52 TMIGD1transmembrane and immunoglobulin domain containing 1 (ENSG00000182271), score: 0.85 TMPRSS13transmembrane protease, serine 13 (ENSG00000137747), score: 0.76 TNFSF15tumor necrosis factor (ligand) superfamily, member 15 (ENSG00000181634), score: 0.75 TRPM6transient receptor potential cation channel, subfamily M, member 6 (ENSG00000119121), score: 0.57 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.5 UCMAupper zone of growth plate and cartilage matrix associated (ENSG00000165623), score: 0.53 UCN3urocortin 3 (stresscopin) (ENSG00000178473), score: 0.95 UMODuromodulin (ENSG00000169344), score: 0.52 UPK2uroplakin 2 (ENSG00000110375), score: 0.71 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (ENSG00000111424), score: 0.49 XPCxeroderma pigmentosum, complementation group C (ENSG00000154767), score: 0.56 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.49

Non-Entrez genes

ENSG00000163814Unknown, score: 0.55

Id	species	tissue	sex	individual
ptr_kd_m_ca1	ptr	kd	m	_
mml_kd_f_ca1	mml	kd	f	_
mml_kd_m_ca1	mml	kd	m	_