Difference between revisions of "Can environment modify genetic effects on human anthropometric traits?"
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#lango-allen2010 Lango Allen et al. ''Hundreds of variants clustered in genomic loci and biological pathways affect human height.'' Nature. 2010 Oct 14;467(7317):832-8. | #lango-allen2010 Lango Allen et al. ''Hundreds of variants clustered in genomic loci and biological pathways affect human height.'' Nature. 2010 Oct 14;467(7317):832-8. | ||
</biblio> | </biblio> | ||
| + | see [[Genome Wide Association Studies]] | ||
Back to [[UNIL BSc course: "Solving Biological Problems that require Math 2011"]]] | Back to [[UNIL BSc course: "Solving Biological Problems that require Math 2011"]]] | ||
Revision as of 19:34, 25 February 2011
Background: Large studies (including hundreds of thousands of individuals) identified genetic factors influencing human height, body-mass-index (BMI) and waist-to-hip ratio (WHR). It is currently unknown whether the effect of the discovered genetic variants are modified by environmental factors.
Goal: The goal of this project is to use the Cohorte Lausannois (CoLaus) data to find environmental factors (e.g. smoking, alcohol consumption, physical activity) that modify genetic effects influencing human height, BMI, WHR.
Mathematical tools: Statistics. The students will learn how to use Matlab to read in large data sets including genetic data; conduct linear and logistic regression and interaction analysis.
Biological or Medical aspects:
Supervisors: Zoltan Kutalik & Diana Marek
Students:
Presentation:
References: <biblio>
- lango-allen2010 Lango Allen et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010 Oct 14;467(7317):832-8.
</biblio> see Genome Wide Association Studies
Back to UNIL BSc course: "Solving Biological Problems that require Math 2011"]
