Genome Wide Association Studies

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Some people in our group work on genome wide association studies (GWAS).

Recommended reading

For an introduction to GWAS, with an emphasis on human studies, you could start with a nice tutorial article [1], and a review of more recent issues [2]. There is also a nice review about approaches for rodent studies [3].

Statistical Methodology


Many statistical methods are implemented in PLINK.

More sophisticated model based genotype imputation and association testing can be performed using IMPUTE and SNPTEST, or using MACH and [1] ProbABEL.

Our own software for association testing using uncertain genotypes is QUICKTEST.

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  1. Error fetching PMID 16983374: [BaldingTutorial]
  2. Error fetching PMID 18398418: [McCarthyReview]
All Medline abstracts: PubMed HubMed