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immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

antigen processing and presentation of peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

antigen processing and presentation

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

antigen processing and presentation of peptide antigen

The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

all

This term is the most general term possible

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

This term is the most general term possible

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

aldo-keto reductase activity

Catalysis of the NADPH-dependent reduction of carbonyl compounds.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

oxidoreductase activity, acting on CH-OH group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.

oxidoreductase activity, acting on the CH-CH group of donors

Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP.

MHC class I receptor activity

Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.

trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

Catalysis of the reaction: NADP+ + trans-1,2-dihydrobenzene-1,2-diol = NADPH + catechol.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

This term is the most general term possible

Id	Pvalue	ExpCount	Count	Size	Term
GO:0032501	1.032e-04	58.43	93 ABLIM1, ADAMTS1, ADAMTS3, AKR1B10, AKR1C1, AKR1C2, ALDH1A3, ALDH3A2, ALDH7A1, BEX1, BMP7, CD24, CDK5RAP2, CELSR1, CELSR3, COL11A1, COL3A1, CREG1, CRIM1, CTGF, CUGBP2, DAZ3, DAZ4, DES, DGKD, DLX2, DLX4, EXT1, F8, FAM65B, FGF13, FLT1, FOXG1, FOXL2, FZD6, GABRA2, GCLC, GREM1, HEXB, HEY1, HLA-DMA, HMGA2, HTATIP2, IL1RAPL1, IL23A, INA, ISL1, ITGA4, L1CAM, LAMB2, LEF1, LIMK1, LUM, LXN, MAFB, MLF1, MLLT3, MOG, MPPED2, MSX2, MYL9, NES, NPTX1, OLIG2, OXTR, PCLO, PDGFRA, PPARGC1A, RARB, RNF114, RPS4X, SEPP1, SERPINE1, SFTPB, SH3GL3, SIM1, SIM2, SLC30A1, SNAP25, SOX9, SPATA20, SSPN, STAT6, STS, TAGLN, TBXA2R, TCF7L2, TGFB2, TGFBI, THBS1, TIMM8A, ULK2, VCAM1	1611	multicellular organismal process
GO:0019882	2.105e-04	1.451	10 B2M, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, THBS1	40	antigen processing and presentation
GO:0007399	4.823e-04	14.58	34 ALDH1A3, ALDH3A2, BEX1, BMP7, CD24, CDK5RAP2, CELSR1, CRIM1, DLX2, FGF13, FOXG1, FZD6, GREM1, HEXB, HEY1, INA, ISL1, L1CAM, LAMB2, LEF1, LIMK1, MAFB, MOG, MPPED2, NES, NPTX1, OLIG2, SEPP1, SH3GL3, SIM1, SIM2, TGFB2, TIMM8A, ULK2	402	nervous system development
GO:0048002	9.185e-04	0.7617	7 B2M, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-E, HLA-F	21	antigen processing and presentation of peptide antigen
GO:0002474	2.540e-03	0.6166	6 B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	17	antigen processing and presentation of peptide antigen via MHC class I
GO:0006955	4.595e-03	10.41	25 B2M, CD24, CFI, CLEC7A, COL3A1, CTSS, FCAR, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, IL1RAPL1, IL23A, KYNU, SPG21, SQSTM1, STAT6, TCF7, TGFB2, THBS1, TNFSF10	287	immune response
GO:0007275	8.278e-03	45.59	70 ABLIM1, ADAMTS1, ALDH1A3, ALDH3A2, BEX1, BMP7, CD24, CDK5RAP2, CELSR1, CELSR3, COL3A1, CREG1, CRIM1, CTGF, DAZ3, DAZ4, DGKD, DLX2, DLX4, EXT1, FAM65B, FGF13, FLT1, FOXG1, FOXL2, FZD6, GREM1, HEXB, HEY1, HLA-DMA, HMGA2, HTATIP2, INA, ISL1, ITGA4, L1CAM, LAMB2, LEF1, LIMK1, MAFB, MLF1, MLLT3, MOG, MPPED2, MSX2, NES, NPTX1, OLIG2, PDGFRA, RARB, RNF114, RPS4X, SEPP1, SERPINE1, SFTPB, SH3GL3, SIM1, SIM2, SLC30A1, SOX9, SPATA20, STAT6, STS, TAGLN, TCF7L2, TGFB2, THBS1, TIMM8A, ULK2, VCAM1	1257	multicellular organismal development
GO:0032502	9.874e-03	67.83	95 ABLIM1, ADAMTS1, AEN, ALDH1A3, ALDH3A2, BEX1, BMP7, CABC1, CBFA2T2, CD24, CDK5RAP2, CDKN1A, CELSR1, CELSR3, COL3A1, CREG1, CRIM1, CTGF, DAZ3, DAZ4, DGKD, DLX2, DLX4, DRAM, EGLN3, EXT1, FAF1, FAM65B, FGF13, FLT1, FOXG1, FOXL2, FZD6, GCLC, GNPTAB, GREM1, HEXB, HEY1, HLA-DMA, HMGA2, HTATIP2, IL2RB, INA, ISL1, ITGA4, ITPR1, L1CAM, LAMB2, LEF1, LIMK1, MAFB, MLF1, MLLT3, MMD, MOG, MPPED2, MSX2, NES, NPTX1, OLIG2, PDGFRA, PLAGL1, PPARGC1A, RARB, RNF114, ROD1, RPS4X, S100A4, SEPP1, SERPINB9, SERPINE1, SFTPB, SGK1, SGMS1, SH3GL3, SIM1, SIM2, SLC30A1, SOX9, SPATA20, SQSTM1, STAT6, STS, SULF1, TAGLN, TCF7L2, TGFB1I1, TGFB2, THBS1, TIMM8A, TNFRSF9, TNFSF10, TRAF5, ULK2, VCAM1	1870	developmental process
GO:0048048	1.016e-02	0.2902	4 ALDH1A3, BMP7, FOXL2, RARB	8	embryonic eye morphogenesis
GO:0048731	1.493e-02	35.8	57 ABLIM1, ADAMTS1, ALDH1A3, ALDH3A2, BEX1, BMP7, CD24, CDK5RAP2, CELSR1, COL3A1, CRIM1, CTGF, DLX2, EXT1, FAM65B, FGF13, FLT1, FOXG1, FOXL2, FZD6, GREM1, HEXB, HEY1, HLA-DMA, HTATIP2, INA, ISL1, ITGA4, L1CAM, LAMB2, LEF1, LIMK1, MAFB, MOG, MPPED2, MSX2, NES, NPTX1, OLIG2, PDGFRA, RARB, SEPP1, SERPINE1, SFTPB, SH3GL3, SIM1, SIM2, SOX9, STAT6, STS, TAGLN, TCF7L2, TGFB2, THBS1, TIMM8A, ULK2, VCAM1	987	system development
GO:0048562	2.219e-02	0.3627	4 ALDH1A3, BMP7, FOXL2, RARB	10	embryonic organ morphogenesis
GO:0030154	2.559e-02	23.87	41 BEX1, BMP7, CBFA2T2, CD24, CDK5RAP2, CTGF, DAZ3, DAZ4, DLX2, FAM65B, FLT1, FOXG1, FOXL2, GNPTAB, HEY1, HLA-DMA, HTATIP2, INA, ISL1, ITGA4, L1CAM, LAMB2, LEF1, LIMK1, MAFB, MLF1, OLIG2, PPARGC1A, RARB, RNF114, S100A4, SIM1, SIM2, SOX9, SPATA20, SQSTM1, TCF7L2, TGFB1I1, TGFB2, ULK2, VCAM1	658	cell differentiation
GO:0007417	2.803e-02	5.549	15 ALDH1A3, ALDH3A2, CDK5RAP2, CELSR1, DLX2, FOXG1, ISL1, LEF1, MAFB, MOG, NES, NPTX1, OLIG2, SEPP1, SH3GL3	153	central nervous system development
GO:0001502	2.968e-02	0.1814	3 CTGF, SOX9, TGFB2	5	cartilage condensation
GO:0002504	3.007e-02	0.399	4 HLA-DMA, HLA-DRB1, HLA-DRB4, THBS1	11	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0030199	3.614e-02	0.7254	5 ADAMTS3, COL11A1, COL3A1, LUM, TGFB2	20	collagen fibril organization
GO:0048663	3.884e-02	0.4352	4 DLX2, ISL1, OLIG2, TGFB2	12	neuron fate commitment
GO:0000041	4.136e-02	1.124	6 FTL, SLC11A1, SLC25A37, SLC30A1, SLC30A5, SLC39A8	31	transition metal ion transport
GO:0007155	4.348e-02	13.35	26 AEBP1, CD24, CD44, CELSR1, CELSR3, COL11A1, COL3A1, CTGF, F8, FAF1, FLRT1, FZD6, ITGA4, L1CAM, LAMB2, NEDD9, NLGN1, SOX9, SSPN, TGFB1I1, TGFB2, TGFBI, THBS1, THBS2, VCAM1, ZYX	368	cell adhesion
GO:0022610	4.348e-02	13.35	26 AEBP1, CD24, CD44, CELSR1, CELSR3, COL11A1, COL3A1, CTGF, F8, FAF1, FLRT1, FZD6, ITGA4, L1CAM, LAMB2, NEDD9, NLGN1, SOX9, SSPN, TGFB1I1, TGFB2, TGFBI, THBS1, THBS2, VCAM1, ZYX	368	biological adhesion

Id	Pvalue	ExpCount	Count	Size	Term
GO:0042611	4.104e-06	0.839	9 B2M, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F	22	MHC protein complex
GO:0005886	2.207e-04	53.73	85 ABCC1, ABCC3, ABCG2, AKAP12, B2M, C18orf1, CADPS2, CD24, CD44, CELSR1, CELSR3, CLEC2B, CPE, CRIM1, CTGF, CYB561, DES, DGKD, EXOC7, F8, FAF1, FCAR, FCGR2A, FLRT1, FLT1, FZD6, G3BP1, GABRA2, GFRA1, GPR126, GPRC5B, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, IL2RB, ITGA4, KCNJ2, KCNK1, L1CAM, LAPTM5, LIMK1, LRPAP1, MAGI2, MMD, MOG, NDRG1, NEDD9, NLGN1, NRN1, NT5E, OXTR, PCLO, PDGFRA, PLCB1, PTPRD, RECK, SERPINE1, SGMS1, SLC11A1, SLC16A6, SLC25A13, SLC30A1, SLC30A5, SLC38A4, SNAP25, SSPN, STOM, STS, SYNGR1, SYT11, TBXA2R, TGFB1I1, THBS1, TNFRSF9, TNFSF10, TNS1, TRHDE, VCAM1, VEZT, ZYX	1409	plasma membrane
GO:0042612	5.558e-04	0.5721	6 B2M, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	15	MHC class I protein complex
GO:0044459	1.297e-03	32.61	56 ABCC1, ABCC3, B2M, CADPS2, CD24, CD44, CELSR1, CLEC2B, CYB561, FAF1, FCAR, FLRT1, FLT1, FZD6, GABRA2, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, IL2RB, ITGA4, KCNJ2, KCNK1, LAPTM5, LIMK1, MAGI2, MMD, NEDD9, NLGN1, OXTR, PCLO, PDGFRA, PTPRD, SLC11A1, SLC16A6, SLC25A13, SLC30A5, SNAP25, SSPN, STOM, SYNGR1, SYT11, TBXA2R, TGFB1I1, THBS1, TNFRSF9, TNFSF10, TNS1, TRHDE, VCAM1, VEZT, ZYX	855	plasma membrane part
GO:0005576	8.303e-03	25.67	44 ADAMTS1, ADAMTS3, AEBP1, AKR1B1, ASPN, B2M, BAGE, BGN, BMP7, C6orf120, CD248, CD44, CFI, COL11A1, COL3A1, CPE, CREG1, CRIM1, CTGF, CTSS, EDEM2, F8, FCAR, FLRT1, FLT1, GREM1, HLA-C, IL23A, LAMB2, LUM, SEPP1, SERPINE1, SFTPB, SPINLW1, SULF1, TGFB2, TGFBI, THBS1, THBS2, TNFSF10, TSKU, VCAM1, WFDC8, ZPBP	673	extracellular region
GO:0031226	1.017e-02	20.56	37 ABCC1, ABCC3, CD24, CD44, CELSR1, CLEC2B, CYB561, FCAR, FLRT1, FLT1, FZD6, HLA-A, HLA-B, HLA-C, HLA-DRB4, IL2RB, ITGA4, KCNJ2, KCNK1, LAPTM5, MMD, OXTR, PDGFRA, PTPRD, SLC11A1, SLC16A6, SLC25A13, SLC30A5, SSPN, STOM, SYNGR1, SYT11, TBXA2R, TNFRSF9, TNFSF10, TRHDE, ZYX	539	intrinsic to plasma membrane
GO:0031224	1.081e-02	76.65	103 ABCC1, ABCC3, ABCG2, ACSL5, ADIPOR1, ALDH3A2, ARMCX1, BAMBI, C18orf1, C20orf39, C7orf23, C9orf125, CD24, CD248, CD44, CELSR1, CELSR3, CLEC2B, CLEC7A, CRIM1, CYB561, CYP3A4, D4S234E, DRAM, EPHX1, ERGIC3, EVI2A, EXT1, FAM174B, FCAR, FCGR2A, FLRT1, FLT1, FZD6, GABRA2, GAL3ST4, GALNT3, GFRA1, GNPTAB, GPR126, GPRC5B, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, HSD17B12, IGSF3, IL1RAPL1, IL2RB, ITGA4, ITPR1, KCNJ2, KCNK1, KCNN2, L1CAM, LAPTM5, LPPR4, LRPAP1, MANSC1, MFSD11, MMD, MOG, MOXD1, NRN1, NT5E, OXTR, PDGFRA, PTPRD, RECK, SCD5, SGMS1, SLC11A1, SLC16A6, SLC25A13, SLC25A37, SLC30A1, SLC30A5, SLC35F2, SLC38A4, SLC39A8, SLC46A3, SPTLC3, SSPN, STOM, STS, SYNGR1, SYT11, TBXA2R, TMEM100, TMEM111, TMEM2, TMEM80, TNFRSF9, TNFSF10, TRHDE, UGT1A8, VCAM1, VEZT, ZYX	2010	intrinsic to membrane
GO:0044425	1.243e-02	90.84	118 ABCC1, ABCC3, ABCG2, ACSL5, ADIPOR1, ALDH3A2, ARMCX1, B2M, BAMBI, C18orf1, C20orf39, C7orf23, C9orf125, CADPS2, CD24, CD248, CD44, CELSR1, CELSR3, CLEC2B, CLEC7A, CRIM1, CYB561, CYP2B6, CYP3A4, D4S234E, DRAM, EPB41L1, EPHX1, ERGIC3, EVI2A, EXT1, FAF1, FAM174B, FARP1, FCAR, FCGR2A, FLRT1, FLT1, FZD6, GABRA2, GAL3ST4, GALNT3, GFRA1, GNPTAB, GPR126, GPRC5B, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, HSD17B12, IGSF3, IL1RAPL1, IL2RB, ITGA4, ITPR1, KCNJ2, KCNK1, KCNN2, L1CAM, LAPTM5, LIMK1, LPPR4, LRPAP1, MAGI2, MANSC1, MFSD11, MMD, MOG, MOXD1, NEDD9, NLGN1, NRN1, NT5E, OXTR, PCLO, PDGFRA, PTPRD, RECK, SCD5, SGMS1, SLC11A1, SLC16A6, SLC25A13, SLC25A37, SLC30A1, SLC30A5, SLC35F2, SLC38A4, SLC39A8, SLC46A3, SNAP25, SPTLC3, SSPN, STOM, STS, SYNGR1, SYT11, TBXA2R, TGFB1I1, THBS1, TMEM100, TMEM111, TMEM2, TMEM80, TNFRSF9, TNFSF10, TNS1, TRHDE, UGT1A8, VCAM1, VEZT, ZYX	2382	membrane part
GO:0005887	1.649e-02	20.4	36 ABCC1, ABCC3, CD44, CELSR1, CLEC2B, CYB561, FCAR, FLRT1, FLT1, FZD6, HLA-A, HLA-B, HLA-C, HLA-DRB4, IL2RB, ITGA4, KCNJ2, KCNK1, LAPTM5, MMD, OXTR, PDGFRA, PTPRD, SLC11A1, SLC16A6, SLC25A13, SLC30A5, SSPN, STOM, SYNGR1, SYT11, TBXA2R, TNFRSF9, TNFSF10, TRHDE, ZYX	535	integral to plasma membrane
GO:0016020	2.813e-02	118.8	145 ABCC1, ABCC3, ABCG2, ABHD2, ACSL5, ADIPOR1, AKAP12, ALDH3A2, APBB2, ARMCX1, B2M, BAMBI, C18orf1, C20orf39, C7orf23, C9orf125, CADPS2, CD24, CD248, CD44, CELSR1, CELSR3, CFI, CLEC2B, CLEC7A, CPE, CRIM1, CTGF, CTSS, CYB561, CYP2B6, CYP3A4, D4S234E, DAPP1, DES, DGKD, DRAM, EDEM2, EPB41L1, EPHX1, ERGIC3, EVI2A, EXOC7, EXOG, EXT1, F8, FAF1, FAM174B, FARP1, FCAR, FCGR2A, FLRT1, FLT1, FZD6, G3BP1, GABRA2, GAL3ST4, GALNT3, GFRA1, GNPTAB, GPR126, GPRC5B, HEXB, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, HSD17B12, IGSF3, IL1RAPL1, IL2RB, ITGA4, ITPR1, KCNJ2, KCNK1, KCNN2, L1CAM, LAPTM5, LIMK1, LPPR4, LRPAP1, MAGI2, MANSC1, MFSD11, MMD, MOG, MOXD1, NDRG1, NEDD9, NLGN1, NRN1, NT5E, OXTR, PCLO, PDGFRA, PEX5, PLCB1, PSTPIP2, PTPRD, RECK, RIPK4, SCD5, SCRIB, SERPINE1, SGMS1, SH3GL3, SIRT3, SLC11A1, SLC16A6, SLC25A13, SLC25A37, SLC30A1, SLC30A5, SLC35F2, SLC38A4, SLC39A8, SLC46A3, SNAP25, SPG21, SPTLC3, SSPN, STOM, STS, SYNGR1, SYT11, TBXA2R, TGFB1I1, THBS1, TIMM8A, TMEM100, TMEM111, TMEM2, TMEM80, TNFRSF9, TNFSF10, TNS1, TRHDE, UGT1A8, VCAM1, VEZT, ZYX	3116	membrane
GO:0042613	4.090e-02	0.267	3 HLA-DMA, HLA-DRB1, HLA-DRB4	7	MHC class II protein complex
GO:0016021	4.381e-02	75.63	98 ABCC1, ABCC3, ABCG2, ACSL5, ADIPOR1, ALDH3A2, ARMCX1, BAMBI, C18orf1, C20orf39, C7orf23, C9orf125, CD248, CD44, CELSR1, CELSR3, CLEC2B, CLEC7A, CRIM1, CYB561, CYP3A4, D4S234E, DRAM, EPHX1, ERGIC3, EVI2A, EXT1, FAM174B, FCAR, FCGR2A, FLRT1, FLT1, FZD6, GABRA2, GAL3ST4, GALNT3, GNPTAB, GPR126, GPRC5B, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, HSD17B12, IGSF3, IL1RAPL1, IL2RB, ITGA4, ITPR1, KCNJ2, KCNK1, KCNN2, L1CAM, LAPTM5, LPPR4, LRPAP1, MANSC1, MFSD11, MMD, MOG, MOXD1, OXTR, PDGFRA, PTPRD, SCD5, SGMS1, SLC11A1, SLC16A6, SLC25A13, SLC25A37, SLC30A1, SLC30A5, SLC35F2, SLC38A4, SLC39A8, SLC46A3, SPTLC3, SSPN, STOM, STS, SYNGR1, SYT11, TBXA2R, TMEM100, TMEM111, TMEM2, TMEM80, TNFRSF9, TNFSF10, TRHDE, UGT1A8, VCAM1, VEZT, ZYX	1983	integral to membrane

Id	Pvalue	ExpCount	Count	Size	Term
GO:0032393	1.502e-03	0.3234	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	9	MHC class I receptor activity
GO:0004033	4.017e-03	0.3952	5 AKR1B1, AKR1B10, AKR1C1, AKR1C3, ALDH3A1	11	aldo-keto reductase activity
GO:0047115	6.946e-03	0.1078	3 AKR1C1, AKR1C2, AKR1C3	3	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
GO:0016620	1.176e-02	0.503	5 ALDH1A1, ALDH1A3, ALDH3A1, ALDH3A2, ALDH7A1	14	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004872	1.223e-02	18.65	36 ADIPOR1, CD44, CELSR1, CELSR3, CFI, CLEC7A, CRIM1, EVI2A, FCAR, FCGR2A, FLT1, FZD6, GABRA2, GFRA1, GPR126, GPRC5B, HLA-A, HLA-B, HLA-C, HLA-DRB4, HLA-E, HLA-F, IL1RAPL1, IL2RB, ITGA4, ITPR1, LRPAP1, MED16, MMD, OXTR, PDGFRA, PTPRD, RARB, RIPK4, TBXA2R, TNFRSF9	519	receptor activity
GO:0004871	1.480e-02	28.03	48 ADIPOR1, CD24, CD44, CELSR1, CELSR3, CFI, CLEC7A, CRIM1, EVI2A, FCAR, FCGR2A, FLRT1, FLT1, FZD6, GABRA2, GFRA1, GPR126, GPRC5B, HLA-A, HLA-B, HLA-C, HLA-DRB4, HLA-E, HLA-F, IL1RAPL1, IL2RB, ITGA4, ITPR1, LRPAP1, MED16, MMD, OXTR, PDGFRA, PLCB1, PLK2, PTPRD, RARB, RIPK4, SH2D3A, SH3BGR, SIM1, SIM2, STAT6, TBXA2R, TGFB2, TNFRSF9, TRAF5, VAV3	780	signal transducer activity
GO:0060089	1.480e-02	28.03	48 ADIPOR1, CD24, CD44, CELSR1, CELSR3, CFI, CLEC7A, CRIM1, EVI2A, FCAR, FCGR2A, FLRT1, FLT1, FZD6, GABRA2, GFRA1, GPR126, GPRC5B, HLA-A, HLA-B, HLA-C, HLA-DRB4, HLA-E, HLA-F, IL1RAPL1, IL2RB, ITGA4, ITPR1, LRPAP1, MED16, MMD, OXTR, PDGFRA, PLCB1, PLK2, PTPRD, RARB, RIPK4, SH2D3A, SH3BGR, SIM1, SIM2, STAT6, TBXA2R, TGFB2, TNFRSF9, TRAF5, VAV3	780	molecular transducer activity
GO:0004867	1.876e-02	1.222	7 CRIM1, RECK, SERPINB7, SERPINB9, SERPINE1, SPINLW1, WFDC8	34	serine-type endopeptidase inhibitor activity
GO:0004030	3.726e-02	0.1796	3 ALDH1A3, ALDH3A1, ALDH3A2	5	aldehyde dehydrogenase [NAD(P)+] activity
GO:0016903	4.447e-02	0.7186	5 ALDH1A1, ALDH1A3, ALDH3A1, ALDH3A2, ALDH7A1	20	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0004888	4.477e-02	11.64	24 CELSR1, CELSR3, CFI, CRIM1, EVI2A, FLT1, FZD6, GABRA2, GFRA1, GPR126, GPRC5B, HLA-A, HLA-B, HLA-C, HLA-DRB4, HLA-E, HLA-F, IL1RAPL1, IL2RB, LRPAP1, OXTR, PDGFRA, PTPRD, TBXA2R	324	transmembrane receptor activity

Id	Pvalue	ExpCount	Count	Size	Term
04940	1.292e-04	1.103	9 CPE, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F	26	Type I diabetes mellitus
05330	2.251e-04	0.8906	8 HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F	21	Allograft rejection
05332	2.251e-04	0.8906	8 HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F	21	Graft-versus-host disease
05320	3.239e-04	0.933	8 HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F	22	Autoimmune thyroid disease
04612	1.690e-03	1.908	10 B2M, CTSS, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F	45	Antigen processing and presentation
00980	2.061e-03	1.569	9 AKR1C1, AKR1C2, AKR1C3, ALDH1A3, ALDH3A1, CYP2B6, CYP3A4, EPHX1, UGT1A8	37	Metabolism of xenobiotics by cytochrome P450
04514	3.200e-03	2.969	12 HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DRB1, HLA-DRB4, HLA-E, HLA-F, ITGA4, L1CAM, NLGN1, VCAM1	70	Cell adhesion molecules (CAMs)
00903	1.498e-02	0.5938	5 ACOT11, ALDH1A3, ALDH3A1, ALDH3A2, ALDH7A1	14	Limonene and pinene degradation
00053	1.513e-02	0.3393	4 ALDH1A3, ALDH3A1, ALDH3A2, ALDH7A1	8	Ascorbate and aldarate metabolism
00641	2.276e-02	0.3817	4 ALDH1A3, ALDH3A1, ALDH3A2, ALDH7A1	9	3-Chloroacrylic acid degradation
00120	3.204e-02	0.721	5 AKR1B10, ALDH1A3, ALDH3A1, ALDH3A2, ALDH7A1	17	Bile acid biosynthesis

No enriched terms

No enriched terms

Entrez genes

ABCC1ATP-binding cassette, sub-family C (CFTR/MRP), member 1 (202804_at), score: -0.5 ABCC3ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (208161_s_at), score: -0.48 ABCG2ATP-binding cassette, sub-family G (WHITE), member 2 (209735_at), score: -0.51 ABHD2abhydrolase domain containing 2 (221815_at), score: -0.48 ABLIM1actin binding LIM protein 1 (200965_s_at), score: 0.68 ACOT11acyl-CoA thioesterase 11 (216103_at), score: -0.55 ACSL5acyl-CoA synthetase long-chain family member 5 (218322_s_at), score: -0.56 ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1 (222162_s_at), score: 0.56 ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif, 3 (214913_at), score: 0.59 ADIPOR1adiponectin receptor 1 (217748_at), score: -0.5 AEBP1AE binding protein 1 (201792_at), score: 0.59 AENapoptosis enhancing nuclease (219361_s_at), score: 0.62 AGAaspartylglucosaminidase (204332_s_at), score: 0.57 AKAP12A kinase (PRKA) anchor protein 12 (210517_s_at), score: 0.59 AKR1B1aldo-keto reductase family 1, member B1 (aldose reductase) (201272_at), score: -0.5 AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase) (206561_s_at), score: -0.81 AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) (204151_x_at), score: -0.59 AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III) (209699_x_at), score: -0.62 AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (209160_at), score: -0.6 ALDH1A1aldehyde dehydrogenase 1 family, member A1 (212224_at), score: 0.68 ALDH1A3aldehyde dehydrogenase 1 family, member A3 (203180_at), score: -0.55 ALDH3A1aldehyde dehydrogenase 3 family, memberA1 (205623_at), score: -0.61 ALDH3A2aldehyde dehydrogenase 3 family, member A2 (202053_s_at), score: -0.5 ALDH7A1aldehyde dehydrogenase 7 family, member A1 (208951_at), score: 0.57 ANKHD1ankyrin repeat and KH domain containing 1 (208773_s_at), score: -0.57 APBB2amyloid beta (A4) precursor protein-binding, family B, member 2 (212972_x_at), score: -0.52 ARL15ADP-ribosylation factor-like 15 (219842_at), score: 0.59 ARMCX1armadillo repeat containing, X-linked 1 (218694_at), score: 0.55 ASPNasporin (219087_at), score: 0.6 B2Mbeta-2-microglobulin (216231_s_at), score: -0.56 BAGEB melanoma antigen (207712_at), score: -0.5 BAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis) (203304_at), score: -0.47 BEX1brain expressed, X-linked 1 (218332_at), score: 0.56 BGNbiglycan (213905_x_at), score: 0.59 BMP7bone morphogenetic protein 7 (209590_at), score: -0.72 C10orf116chromosome 10 open reading frame 116 (203571_s_at), score: 0.63 C10orf81chromosome 10 open reading frame 81 (219857_at), score: -0.57 C13orf15chromosome 13 open reading frame 15 (218723_s_at), score: 0.59 C14orf169chromosome 14 open reading frame 169 (219526_at), score: 0.72 C15orf29chromosome 15 open reading frame 29 (218791_s_at), score: 0.56 C18orf1chromosome 18 open reading frame 1 (209574_s_at), score: -0.53 C20orf39chromosome 20 open reading frame 39 (219310_at), score: -0.64 C21orf7chromosome 21 open reading frame 7 (221211_s_at), score: 0.57 C6orf120chromosome 6 open reading frame 120 (221786_at), score: 0.55 C7orf23chromosome 7 open reading frame 23 (204215_at), score: -0.5 C7orf64chromosome 7 open reading frame 64 (221596_s_at), score: -0.47 C9orf125chromosome 9 open reading frame 125 (213386_at), score: 0.57 CABC1chaperone, ABC1 activity of bc1 complex homolog (S. pombe) (218168_s_at), score: -0.47 CADPS2Ca++-dependent secretion activator 2 (219572_at), score: -0.46 CAND2cullin-associated and neddylation-dissociated 2 (putative) (213547_at), score: 0.7 CBFA2T2core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (207625_s_at), score: -0.48 CD24CD24 molecule (266_s_at), score: -0.5 CD248CD248 molecule, endosialin (219025_at), score: 0.6 CD44CD44 molecule (Indian blood group) (210916_s_at), score: -0.46 CDK5RAP2CDK5 regulatory subunit associated protein 2 (220935_s_at), score: -0.46 CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1) (202284_s_at), score: 0.61 CDKN1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2) (213183_s_at), score: -0.5 CELSR1cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) (41660_at), score: -0.77 CELSR3cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) (40020_at), score: -0.72 CFIcomplement factor I (203854_at), score: -0.58 CIRCBF1 interacting corepressor (209571_at), score: -0.47 CLEC2BC-type lectin domain family 2, member B (209732_at), score: -0.58 CLEC7AC-type lectin domain family 7, member A (221698_s_at), score: -0.48 CNN3calponin 3, acidic (201445_at), score: 0.56 COBLL1COBL-like 1 (203642_s_at), score: 0.63 COL11A1collagen, type XI, alpha 1 (37892_at), score: 0.59 COL3A1collagen, type III, alpha 1 (215076_s_at), score: 0.62 CPEcarboxypeptidase E (201117_s_at), score: -0.5 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: -0.62 CRIM1cysteine rich transmembrane BMP regulator 1 (chordin-like) (202552_s_at), score: 0.56 CTGFconnective tissue growth factor (209101_at), score: 0.64 CTSScathepsin S (202901_x_at), score: -0.68 CUGBP2CUG triplet repeat, RNA binding protein 2 (202158_s_at), score: 0.56 CYB561cytochrome b-561 (209163_at), score: -0.49 CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 6 (217133_x_at), score: -0.58 CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 4 (205998_x_at), score: -0.5 D4S234EDNA segment on chromosome 4 (unique) 234 expressed sequence (209569_x_at), score: -0.52 DAPP1dual adaptor of phosphotyrosine and 3-phosphoinositides (219290_x_at), score: -0.52 DAZ3deleted in azoospermia 3 (208281_x_at), score: -0.53 DAZ4deleted in azoospermia 4 (216351_x_at), score: -0.55 DBTdihydrolipoamide branched chain transacylase E2 (205370_x_at), score: -0.5 DDAH1dimethylarginine dimethylaminohydrolase 1 (209094_at), score: 0.67 DESdesmin (216947_at), score: -0.51 DGKDdiacylglycerol kinase, delta 130kDa (208072_s_at), score: -0.66 DLX2distal-less homeobox 2 (207147_at), score: -0.47 DLX4distal-less homeobox 4 (208216_at), score: -0.64 DNAH3dynein, axonemal, heavy chain 3 (220725_x_at), score: -0.59 DNAJC6DnaJ (Hsp40) homolog, subfamily C, member 6 (204720_s_at), score: 0.57 DRAMdamage-regulated autophagy modulator (218627_at), score: 0.61 EDEM2ER degradation enhancer, mannosidase alpha-like 2 (218282_at), score: -0.48 EGLN3egl nine homolog 3 (C. elegans) (219232_s_at), score: -0.66 ENOSF1enolase superfamily member 1 (204142_at), score: 0.61 EPB41L1erythrocyte membrane protein band 4.1-like 1 (212339_at), score: -0.6 EPHX1epoxide hydrolase 1, microsomal (xenobiotic) (202017_at), score: -0.53 ERGIC3ERGIC and golgi 3 (216032_s_at), score: -0.54 EVI2Aecotropic viral integration site 2A (204774_at), score: -0.49 EXOC7exocyst complex component 7 (212034_s_at), score: 0.58 EXOGendo/exonuclease (5'-3'), endonuclease G-like (205521_at), score: 0.55 EXT1exostoses (multiple) 1 (201995_at), score: 0.56 F8coagulation factor VIII, procoagulant component (205756_s_at), score: -0.52 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: 0.56 FAF1Fas (TNFRSF6) associated factor 1 (218080_x_at), score: 0.61 FAM105Afamily with sequence similarity 105, member A (219694_at), score: -0.48 FAM174Bfamily with sequence similarity 174, member B (51158_at), score: 0.89 FAM46Cfamily with sequence similarity 46, member C (220306_at), score: 0.8 FAM65Bfamily with sequence similarity 65, member B (209829_at), score: 0.75 FAM98Afamily with sequence similarity 98, member A (212333_at), score: 0.57 FARP1FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) (201911_s_at), score: 0.59 FCARFc fragment of IgA, receptor for (211305_x_at), score: -0.51 FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32) (203561_at), score: -0.82 FGF13fibroblast growth factor 13 (205110_s_at), score: -0.64 FLJ11292hypothetical protein FLJ11292 (220828_s_at), score: -0.57 FLJ23172hypothetical LOC389177 (217016_x_at), score: -0.49 FLJ42627hypothetical LOC645644 (220352_x_at), score: -0.48 FLRT1fibronectin leucine rich transmembrane protein 1 (210414_at), score: -0.48 FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) (222033_s_at), score: 0.68 FOXG1forkhead box G1 (206018_at), score: -0.56 FOXL2forkhead box L2 (220102_at), score: -0.53 FTLferritin, light polypeptide (213187_x_at), score: -0.51 FZD6frizzled homolog 6 (Drosophila) (203987_at), score: 0.56 G3BP1GTPase activating protein (SH3 domain) binding protein 1 (222187_x_at), score: -0.52 GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 2 (207014_at), score: -0.68 GAL3ST4galactose-3-O-sulfotransferase 4 (219815_at), score: 0.7 GALCgalactosylceramidase (204417_at), score: 0.63 GALNT3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (203397_s_at), score: 0.68 GCLCglutamate-cysteine ligase, catalytic subunit (202922_at), score: -0.61 GFRA1GDNF family receptor alpha 1 (205696_s_at), score: 0.76 GIPC2GIPC PDZ domain containing family, member 2 (219970_at), score: 0.59 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: 0.63 GPR126G protein-coupled receptor 126 (213094_at), score: 0.67 GPRC5BG protein-coupled receptor, family C, group 5, member B (203632_s_at), score: -0.53 GRAMD3GRAM domain containing 3 (218706_s_at), score: 0.65 GREM1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) (218469_at), score: 1 HCG2P7HLA complex group 2 pseudogene 7 (216229_x_at), score: -0.5 HEXBhexosaminidase B (beta polypeptide) (201944_at), score: -0.51 HEY1hairy/enhancer-of-split related with YRPW motif 1 (44783_s_at), score: -0.7 HLA-Amajor histocompatibility complex, class I, A (213932_x_at), score: -0.55 HLA-Bmajor histocompatibility complex, class I, B (211911_x_at), score: -0.56 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: -0.51 HLA-DMAmajor histocompatibility complex, class II, DM alpha (217478_s_at), score: -0.51 HLA-DRB1major histocompatibility complex, class II, DR beta 1 (209312_x_at), score: -0.67 HLA-DRB4major histocompatibility complex, class II, DR beta 4 (208306_x_at), score: -0.54 HLA-Emajor histocompatibility complex, class I, E (200904_at), score: -0.47 HLA-Fmajor histocompatibility complex, class I, F (204806_x_at), score: -0.49 HMGA2high mobility group AT-hook 2 (208025_s_at), score: 0.57 HSD17B12hydroxysteroid (17-beta) dehydrogenase 12 (217869_at), score: 0.56 HTATIP2HIV-1 Tat interactive protein 2, 30kDa (209448_at), score: 0.61 IGSF3immunoglobulin superfamily, member 3 (202421_at), score: -0.74 IL1RAPL1interleukin 1 receptor accessory protein-like 1 (220663_at), score: -0.58 IL23Ainterleukin 23, alpha subunit p19 (211796_s_at), score: 0.78 IL2RBinterleukin 2 receptor, beta (205291_at), score: -0.47 INAinternexin neuronal intermediate filament protein, alpha (204465_s_at), score: 0.63 INPP4Binositol polyphosphate-4-phosphatase, type II, 105kDa (205376_at), score: 0.6 ISL1ISL LIM homeobox 1 (206104_at), score: 0.66 ITGA4integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) (213416_at), score: 0.62 ITPK1inositol 1,3,4-triphosphate 5/6 kinase (210740_s_at), score: 0.57 ITPR1inositol 1,4,5-triphosphate receptor, type 1 (203710_at), score: -0.49 KCNJ2potassium inwardly-rectifying channel, subfamily J, member 2 (206765_at), score: 0.64 KCNK1potassium channel, subfamily K, member 1 (204679_at), score: -0.47 KCNN2potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 (220116_at), score: 0.63 KHDRBS3KH domain containing, RNA binding, signal transduction associated 3 (209781_s_at), score: 0.56 KIAA0802KIAA0802 (213358_at), score: 0.6 KIR3DX1killer cell immunoglobulin-like receptor, three domains, X1 (216428_x_at), score: -0.48 KLHL3kelch-like 3 (Drosophila) (221221_s_at), score: 0.57 KYNUkynureninase (L-kynurenine hydrolase) (217388_s_at), score: -0.98 L1CAML1 cell adhesion molecule (204584_at), score: 0.67 LAMB2laminin, beta 2 (laminin S) (216264_s_at), score: 0.59 LAPTM5lysosomal multispanning membrane protein 5 (201721_s_at), score: -0.48 LEF1lymphoid enhancer-binding factor 1 (221558_s_at), score: -0.84 LIMK1LIM domain kinase 1 (204357_s_at), score: -0.47 LMO7LIM domain 7 (202674_s_at), score: 0.66 LOC100132247similar to Uncharacterized protein KIAA0220 (215002_at), score: -0.52 LOC282997hypothetical protein LOC282997 (222307_at), score: -0.48 LOC51152melanoma antigen (220771_at), score: -0.51 LOC643313similar to hypothetical protein LOC284701 (211050_x_at), score: -0.59 LOC647070hypothetical LOC647070 (215467_x_at), score: -0.58 LPPR4plasticity related gene 1 (213496_at), score: 0.64 LRPAP1low density lipoprotein receptor-related protein associated protein 1 (201186_at), score: 0.55 LUMlumican (201744_s_at), score: 0.76 LXNlatexin (218729_at), score: 0.56 MAFBv-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) (218559_s_at), score: -0.54 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: 0.63 MAMLD1mastermind-like domain containing 1 (205088_at), score: 0.66 MANSC1MANSC domain containing 1 (220945_x_at), score: 0.58 MAP1Amicrotubule-associated protein 1A (203151_at), score: 0.56 MAP2K7mitogen-activated protein kinase kinase 7 (216206_x_at), score: -0.48 MED16mediator complex subunit 16 (43544_at), score: 0.58 MED31mediator complex subunit 31 (219318_x_at), score: -0.52 MEFVMediterranean fever (208262_x_at), score: -0.55 METTL7Amethyltransferase like 7A (211424_x_at), score: -0.51 MFSD11major facilitator superfamily domain containing 11 (221192_x_at), score: -0.48 MKRN2makorin ring finger protein 2 (218071_s_at), score: 0.56 MLF1myeloid leukemia factor 1 (204784_s_at), score: -0.57 MLLT3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 (204918_s_at), score: 0.63 MMDmonocyte to macrophage differentiation-associated (203414_at), score: -0.5 MOGmyelin oligodendrocyte glycoprotein (214650_x_at), score: -0.5 MOXD1monooxygenase, DBH-like 1 (209708_at), score: 0.59 MPPED2metallophosphoesterase domain containing 2 (205413_at), score: -0.9 MRPL52mitochondrial ribosomal protein L52 (221997_s_at), score: 0.57 MSX2msh homeobox 2 (210319_x_at), score: -0.49 MYL9myosin, light chain 9, regulatory (201058_s_at), score: 0.61 MYO1Bmyosin IB (212364_at), score: 0.77 NACA2nascent polypeptide-associated complex alpha subunit 2 (222224_at), score: -0.53 NDRG1N-myc downstream regulated 1 (200632_s_at), score: -0.7 NEDD9neural precursor cell expressed, developmentally down-regulated 9 (202149_at), score: 0.57 NESnestin (218678_at), score: 0.64 NFE2L2nuclear factor (erythroid-derived 2)-like 2 (201146_at), score: -0.57 NLGN1neuroligin 1 (205893_at), score: 0.6 NOSIPnitric oxide synthase interacting protein (217950_at), score: 0.55 NPTX1neuronal pentraxin I (204684_at), score: -0.65 NRN1neuritin 1 (218625_at), score: -0.59 NT5E5'-nucleotidase, ecto (CD73) (203939_at), score: 0.67 OLIG2oligodendrocyte lineage transcription factor 2 (213825_at), score: -0.51 OXTRoxytocin receptor (206825_at), score: 0.67 PCGF1polycomb group ring finger 1 (210023_s_at), score: -0.47 PCLOpiccolo (presynaptic cytomatrix protein) (213558_at), score: -0.47 PDGFRAplatelet-derived growth factor receptor, alpha polypeptide (203131_at), score: 0.59 PDLIM1PDZ and LIM domain 1 (208690_s_at), score: 0.66 PEX5peroxisomal biogenesis factor 5 (203244_at), score: -0.63 PFDN2prefoldin subunit 2 (218336_at), score: -0.5 PLAGL1pleiomorphic adenoma gene-like 1 (209318_x_at), score: 0.58 PLCB1phospholipase C, beta 1 (phosphoinositide-specific) (213222_at), score: 0.63 PLK2polo-like kinase 2 (Drosophila) (201939_at), score: -0.5 POLR1Bpolymerase (RNA) I polypeptide B, 128kDa (220113_x_at), score: -0.51 POM121L9PPOM121 membrane glycoprotein-like 9 (rat) pseudogene (222253_s_at), score: -0.67 POP7processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) (209482_at), score: 0.56 PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha (219195_at), score: -0.64 PRKCDBPprotein kinase C, delta binding protein (213010_at), score: 0.64 PSTPIP2proline-serine-threonine phosphatase interacting protein 2 (219938_s_at), score: 0.64 PTPRDprotein tyrosine phosphatase, receptor type, D (214043_at), score: 0.62 RAB32RAB32, member RAS oncogene family (204214_s_at), score: 0.56 RARBretinoic acid receptor, beta (205080_at), score: -0.51 RASL11BRAS-like, family 11, member B (219142_at), score: 0.6 RBM47RNA binding motif protein 47 (218035_s_at), score: -0.63 RECKreversion-inducing-cysteine-rich protein with kazal motifs (205407_at), score: 0.55 RIPK4receptor-interacting serine-threonine kinase 4 (221215_s_at), score: -0.64 RNF114ring finger protein 114 (200867_at), score: -0.48 RNPEPL1arginyl aminopeptidase (aminopeptidase B)-like 1 (218301_at), score: 0.57 ROD1ROD1 regulator of differentiation 1 (S. pombe) (214697_s_at), score: 0.59 RP4-692D3.1hypothetical protein LOC728621 (221171_at), score: -0.47 RPL21P68ribosomal protein L21 pseudogene 68 (217340_at), score: -0.5 RPL30ribosomal protein L30 (200062_s_at), score: -0.47 RPLP0P6ribosomal protein, large, P0 pseudogene 6 (214167_s_at), score: -0.49 RPS4P17ribosomal protein S4X pseudogene 17 (216342_x_at), score: -0.62 RPS4Xribosomal protein S4, X-linked (200933_x_at), score: -0.58 S100A4S100 calcium binding protein A4 (203186_s_at), score: 0.65 SAMD4Asterile alpha motif domain containing 4A (212845_at), score: 0.58 SAPS2SAPS domain family, member 2 (202792_s_at), score: -0.5 SAT1spermidine/spermine N1-acetyltransferase 1 (213988_s_at), score: -0.49 SCAND2SCAN domain containing 2 pseudogene (222177_s_at), score: -0.49 SCD5stearoyl-CoA desaturase 5 (220232_at), score: -0.53 SCRIBscribbled homolog (Drosophila) (212556_at), score: 0.66 SEPHS2selenophosphate synthetase 2 (200961_at), score: -0.49 SEPP1selenoprotein P, plasma, 1 (201427_s_at), score: -0.46 SERPINB7serpin peptidase inhibitor, clade B (ovalbumin), member 7 (206421_s_at), score: 0.63 SERPINB9serpin peptidase inhibitor, clade B (ovalbumin), member 9 (209723_at), score: 0.75 SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 (202627_s_at), score: 0.65 SFTPBsurfactant protein B (214354_x_at), score: -0.49 SGK1serum/glucocorticoid regulated kinase 1 (201739_at), score: 0.59 SGMS1sphingomyelin synthase 1 (212989_at), score: 0.55 SH2D3ASH2 domain containing 3A (222169_x_at), score: -0.51 SH3BGRSH3 domain binding glutamic acid-rich protein (204979_s_at), score: -0.59 SH3BGRL3SH3 domain binding glutamic acid-rich protein like 3 (221269_s_at), score: 0.56 SH3GL3SH3-domain GRB2-like 3 (211565_at), score: -0.54 SIM1single-minded homolog 1 (Drosophila) (206876_at), score: 0.57 SIM2single-minded homolog 2 (Drosophila) (206558_at), score: -0.52 SIRT3sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae) (221562_s_at), score: -0.54 SKP1S-phase kinase-associated protein 1 (200719_at), score: -0.47 SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (217473_x_at), score: -0.47 SLC16A6solute carrier family 16, member 6 (monocarboxylic acid transporter 7) (207038_at), score: -0.5 SLC25A13solute carrier family 25, member 13 (citrin) (203775_at), score: -0.51 SLC25A37solute carrier family 25, member 37 (218136_s_at), score: -0.49 SLC30A1solute carrier family 30 (zinc transporter), member 1 (212907_at), score: 0.59 SLC30A5solute carrier family 30 (zinc transporter), member 5 (220181_x_at), score: -0.49 SLC35F2solute carrier family 35, member F2 (218826_at), score: -0.48 SLC38A4solute carrier family 38, member 4 (220786_s_at), score: 0.79 SLC39A8solute carrier family 39 (zinc transporter), member 8 (209267_s_at), score: -0.49 SLC46A3solute carrier family 46, member 3 (214719_at), score: -0.51 SMA4glucuronidase, beta pseudogene (215599_at), score: -0.47 SMA5glucuronidase, beta pseudogene (215043_s_at), score: -0.57 SNAP25synaptosomal-associated protein, 25kDa (202508_s_at), score: -0.55 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: -0.49 SPANXCSPANX family, member C (220217_x_at), score: -0.62 SPATA20spermatogenesis associated 20 (218164_at), score: 0.59 SPG21spastic paraplegia 21 (autosomal recessive, Mast syndrome) (215383_x_at), score: -0.47 SPINLW1serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin) (206318_at), score: -0.6 SPTLC3serine palmitoyltransferase, long chain base subunit 3 (220456_at), score: -0.57 SQSTM1sequestosome 1 (201471_s_at), score: -0.59 SSPNsarcospan (Kras oncogene-associated gene) (204963_at), score: 0.6 SSX3synovial sarcoma, X breakpoint 3 (215881_x_at), score: -0.5 STAT6signal transducer and activator of transcription 6, interleukin-4 induced (201331_s_at), score: 0.58 STOMstomatin (201060_x_at), score: 0.55 STSsteroid sulfatase (microsomal), isozyme S (203767_s_at), score: 0.6 SULF1sulfatase 1 (212353_at), score: 0.67 SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (203615_x_at), score: -0.6 SULT1A2sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 (207122_x_at), score: -0.6 SYNGR1synaptogyrin 1 (210613_s_at), score: 0.69 SYT11synaptotagmin XI (209198_s_at), score: 0.58 TAGLNtransgelin (205547_s_at), score: 0.68 TBXA2Rthromboxane A2 receptor (336_at), score: 0.79 TCF7transcription factor 7 (T-cell specific, HMG-box) (205255_x_at), score: -0.47 TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box) (212761_at), score: 0.58 TEStestis derived transcript (3 LIM domains) (202720_at), score: 0.69 TGFB1I1transforming growth factor beta 1 induced transcript 1 (209651_at), score: 0.6 TGFB2transforming growth factor, beta 2 (220407_s_at), score: -0.61 TGFBItransforming growth factor, beta-induced, 68kDa (201506_at), score: -0.51 TGIF2TGFB-induced factor homeobox 2 (216262_s_at), score: -0.48 THBS1thrombospondin 1 (201109_s_at), score: 0.62 THBS2thrombospondin 2 (203083_at), score: 0.62 TIMM8Atranslocase of inner mitochondrial membrane 8 homolog A (yeast) (210800_at), score: -0.57 TMEM100transmembrane protein 100 (219230_at), score: -0.46 TMEM111transmembrane protein 111 (217882_at), score: -0.51 TMEM2transmembrane protein 2 (218113_at), score: 0.55 TMEM80transmembrane protein 80 (221951_at), score: -0.46 TNFRSF9tumor necrosis factor receptor superfamily, member 9 (207536_s_at), score: -0.48 TNFSF10tumor necrosis factor (ligand) superfamily, member 10 (214329_x_at), score: -0.52 TNS1tensin 1 (221748_s_at), score: 0.59 TRAF5TNF receptor-associated factor 5 (204352_at), score: 0.6 TRHDEthyrotropin-releasing hormone degrading enzyme (219937_at), score: 0.6 TSC22D1TSC22 domain family, member 1 (215111_s_at), score: -0.56 TSKUtsukushin (218245_at), score: -0.5 TSPYL5TSPY-like 5 (213122_at), score: 0.62 TTC35tetratricopeptide repeat domain 35 (203584_at), score: -0.5 TUBB6tubulin, beta 6 (209191_at), score: 0.72 TXNL4Bthioredoxin-like 4B (218794_s_at), score: -0.48 UGT1A8UDP glucuronosyltransferase 1 family, polypeptide A8 (221304_at), score: -0.46 ULK2unc-51-like kinase 2 (C. elegans) (204062_s_at), score: 0.6 VAV3vav 3 guanine nucleotide exchange factor (218807_at), score: -0.61 VCAM1vascular cell adhesion molecule 1 (203868_s_at), score: -0.57 VEZTvezatin, adherens junctions transmembrane protein (207263_x_at), score: -0.48 VGLL3vestigial like 3 (Drosophila) (220327_at), score: 0.71 WDR43WD repeat domain 43 (214662_at), score: 0.57 WFDC8WAP four-disulfide core domain 8 (215276_at), score: -0.55 WT1Wilms tumor 1 (206067_s_at), score: -0.54 ZC3H7Bzinc finger CCCH-type containing 7B (206169_x_at), score: -0.53 ZNF212zinc finger protein 212 (203985_at), score: -0.5 ZNF215zinc finger protein 215 (220214_at), score: 0.63 ZNF518Azinc finger protein 518A (204291_at), score: 0.63 ZNF816Azinc finger protein 816A (217541_x_at), score: -0.49 ZPBPzona pellucida binding protein (207021_at), score: -0.5 ZYXzyxin (200808_s_at), score: 0.56

Non-Entrez genes

209732_atUnknown, score: -0.48 214697_s_atUnknown, score: -0.52

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
E-GEOD-4219-raw-cel-1311956457.cel	14	7	Sph-mono	hgu133plus2	none	Sph-mon 1
E-GEOD-4219-raw-cel-1311956138.cel	4	7	Sph-mono	hgu133plus2	none	Sph-mon 1
E-GEOD-4219-raw-cel-1311956358.cel	10	7	Sph-mono	hgu133plus2	none	Sph-mon 1
E-GEOD-4219-raw-cel-1311956178.cel	6	7	Sph-mono	hgu133plus2	none	Sph-mon 1
E-GEOD-4219-raw-cel-1311956824.cel	24	7	Sph-mono	hgu133plus2	none	Sph-mon 1