Under-expression is coded with green,
over-expression with red color.
skeletal system development
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
ossification
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
bone mineralization
The deposition of calcium phosphate in bone tissue.
biomineral formation
Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
bone development
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
all
This term is the most general term possible
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
ossification
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
bone development
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
bone mineralization
The deposition of calcium phosphate in bone tissue.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
proteinaceous extracellular matrix
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
dystrophin-associated glycoprotein complex
A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
extracellular matrix
A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
This term is the most general term possible
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
dystrophin-associated glycoprotein complex
A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
calcium ion binding
Interacting selectively with calcium ions (Ca2+).
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
structural molecule activity
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.
extracellular matrix structural constituent
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
metal ion binding
Interacting selectively with any metal ion.
ion binding
Interacting selectively with ions, charged atoms or groups of atoms.
cation binding
Interacting selectively with cations, charged atoms or groups of atoms with a net positive charge.
all
This term is the most general term possible
calcium ion binding
Interacting selectively with calcium ions (Ca2+).
ANK3ankyrin 3, node of Ranvier (ankyrin G) (206385_s_at), score: -0.78 ANKRD1ankyrin repeat domain 1 (cardiac muscle) (206029_at), score: -0.79 AUTS2autism susceptibility candidate 2 (212599_at), score: 0.79 BACE2beta-site APP-cleaving enzyme 2 (217867_x_at), score: 0.69 BST1bone marrow stromal cell antigen 1 (205715_at), score: -0.85 C1orf54chromosome 1 open reading frame 54 (219506_at), score: -0.8 C1QTNF3C1q and tumor necrosis factor related protein 3 (220988_s_at), score: 0.67 CAMK2N1calcium/calmodulin-dependent protein kinase II inhibitor 1 (218309_at), score: 0.9 CAPGcapping protein (actin filament), gelsolin-like (201850_at), score: 0.72 CCDC81coiled-coil domain containing 81 (220389_at), score: -0.74 CCR10chemokine (C-C motif) receptor 10 (220565_at), score: -0.7 COBLL1COBL-like 1 (203642_s_at), score: -0.7 COL4A1collagen, type IV, alpha 1 (211981_at), score: -0.71 COL4A5collagen, type IV, alpha 5 (213110_s_at), score: -0.7 COMPcartilage oligomeric matrix protein (205713_s_at), score: 0.71 CTSCcathepsin C (201487_at), score: -0.75 CYFIP2cytoplasmic FMR1 interacting protein 2 (215785_s_at), score: -0.71 CYP1B1cytochrome P450, family 1, subfamily B, polypeptide 1 (202436_s_at), score: -0.7 DMDdystrophin (203881_s_at), score: -0.72 EDIL3EGF-like repeats and discoidin I-like domains 3 (207379_at), score: -0.71 EMX2empty spiracles homeobox 2 (221950_at), score: 0.68 ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 (205066_s_at), score: 0.79 EPHA5EPH receptor A5 (215664_s_at), score: -0.81 F2Rcoagulation factor II (thrombin) receptor (203989_x_at), score: -0.81 FHOD3formin homology 2 domain containing 3 (218980_at), score: 0.7 FOXE1forkhead box E1 (thyroid transcription factor 2) (206912_at), score: -0.76 FRMD4AFERM domain containing 4A (208476_s_at), score: -0.72 FSTfollistatin (204948_s_at), score: -0.79 GABBR2gamma-aminobutyric acid (GABA) B receptor, 2 (209990_s_at), score: 0.71 GALNT3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (203397_s_at), score: -0.7 GPERG protein-coupled estrogen receptor 1 (210640_s_at), score: 0.69 GPR116G protein-coupled receptor 116 (212950_at), score: -1 HMOX1heme oxygenase (decycling) 1 (203665_at), score: 0.76 HOXB7homeobox B7 (204779_s_at), score: 0.74 HS3ST3A1heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 (219985_at), score: 0.86 ISLRimmunoglobulin superfamily containing leucine-rich repeat (207191_s_at), score: 0.82 ITGA8integrin, alpha 8 (214265_at), score: -0.74 JAG1jagged 1 (Alagille syndrome) (216268_s_at), score: -0.89 KALRNkalirin, RhoGEF kinase (206078_at), score: -0.77 KCNE4potassium voltage-gated channel, Isk-related family, member 4 (222379_at), score: -0.75 KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (204401_at), score: 0.7 KLF9Kruppel-like factor 9 (203543_s_at), score: -0.71 KRT18keratin 18 (201596_x_at), score: -0.74 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: -0.75 LGR5leucine-rich repeat-containing G protein-coupled receptor 5 (213880_at), score: -0.73 LMO2LIM domain only 2 (rhombotin-like 1) (204249_s_at), score: -0.85 LPHN2latrophilin 2 (206953_s_at), score: -0.82 LPXNleupaxin (216250_s_at), score: 0.73 LRRC15leucine rich repeat containing 15 (213909_at), score: 0.86 LRRC17leucine rich repeat containing 17 (205381_at), score: -0.77 LRRC32leucine rich repeat containing 32 (203835_at), score: -0.71 MBPmyelin basic protein (210136_at), score: -0.88 MEOX2mesenchyme homeobox 2 (206201_s_at), score: -0.93 MESTmesoderm specific transcript homolog (mouse) (202016_at), score: -0.8 MGPmatrix Gla protein (202291_s_at), score: -0.89 MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (201069_at), score: 0.79 MSX1msh homeobox 1 (205932_s_at), score: 0.78 MT1Mmetallothionein 1M (217546_at), score: 0.66 MYCT1myc target 1 (220471_s_at), score: -0.7 NBL1neuroblastoma, suppression of tumorigenicity 1 (37005_at), score: 0.72 NDNnecdin homolog (mouse) (209550_at), score: 0.69 NDUFA4L2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (218484_at), score: -0.89 NEFMneurofilament, medium polypeptide (205113_at), score: -0.75 NET1neuroepithelial cell transforming 1 (201830_s_at), score: 0.77 NID2nidogen 2 (osteonidogen) (204114_at), score: -0.7 NKX3-1NK3 homeobox 1 (209706_at), score: 0.75 NOVnephroblastoma overexpressed gene (214321_at), score: -0.77 NRG1neuregulin 1 (206343_s_at), score: 0.69 NRXN3neurexin 3 (205795_at), score: -0.82 OLFML3olfactomedin-like 3 (218162_at), score: 0.66 PBX1pre-B-cell leukemia homeobox 1 (212148_at), score: 0.69 PDE10Aphosphodiesterase 10A (205501_at), score: -0.72 PLA2G16phospholipase A2, group XVI (209581_at), score: -0.71 PNMA2paraneoplastic antigen MA2 (209598_at), score: -0.82 PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit (218292_s_at), score: -0.77 PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (204469_at), score: -0.94 RELNreelin (205923_at), score: -0.89 RGS7regulator of G-protein signaling 7 (206290_s_at), score: -0.77 RTN1reticulon 1 (203485_at), score: -0.76 SFRP1secreted frizzled-related protein 1 (202036_s_at), score: 0.71 SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein) (213543_at), score: 0.74 SLC24A3solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 (57588_at), score: -0.8 SLC25A4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (202825_at), score: -0.78 SLC7A8solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (216092_s_at), score: 0.82 SLCO3A1solute carrier organic anion transporter family, member 3A1 (219229_at), score: 0.68 SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) (208608_s_at), score: -0.72 SOBPsine oculis binding protein homolog (Drosophila) (218974_at), score: -0.73 SRGNserglycin (201859_at), score: -0.73 SSX2IPsynovial sarcoma, X breakpoint 2 interacting protein (203016_s_at), score: 0.7 STAT1signal transducer and activator of transcription 1, 91kDa (AFFX-HUMISGF3A/M97935_MA_at), score: -0.7 STAT4signal transducer and activator of transcription 4 (206118_at), score: -0.72 STMN2stathmin-like 2 (203000_at), score: 0.76 TCF7L1transcription factor 7-like 1 (T-cell specific, HMG-box) (221016_s_at), score: -0.71 TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) (209676_at), score: -0.73 TINAGL1tubulointerstitial nephritis antigen-like 1 (219058_x_at), score: -0.88 TMEM158transmembrane protein 158 (213338_at), score: 0.89 TNXAtenascin XA pseudogene (213451_x_at), score: -0.87 TNXBtenascin XB (216333_x_at), score: -0.87 TRPV2transient receptor potential cation channel, subfamily V, member 2 (219282_s_at), score: -0.72 TUFT1tuftelin 1 (205807_s_at), score: -0.73 WWP2WW domain containing E3 ubiquitin protein ligase 2 (204022_at), score: -0.77 ZNF423zinc finger protein 423 (214761_at), score: -0.91 ZNF536zinc finger protein 536 (206403_at), score: 0.71
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-GEOD-3860-raw-cel-1561690336.cel | 9 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690231.cel | 4 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690432.cel | 16 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690248.cel | 5 | 5 | HGPS | hgu133a | HGPS | AG11513 |
| E-GEOD-3860-raw-cel-1561690416.cel | 15 | 5 | HGPS | hgu133a | none | GM0316B |
| E-GEOD-3860-raw-cel-1561690304.cel | 8 | 5 | HGPS | hgu133a | none | GMO8398C |
| E-GEOD-3860-raw-cel-1561690472.cel | 17 | 5 | HGPS | hgu133a | none | GM00038C |
| E-GEOD-3860-raw-cel-1561690344.cel | 10 | 5 | HGPS | hgu133a | none | GM00038C |
| E-GEOD-3860-raw-cel-1561690360.cel | 12 | 5 | HGPS | hgu133a | none | GM0316B |
| E-GEOD-3860-raw-cel-1561690223.cel | 3 | 5 | HGPS | hgu133a | none | GM00038C |
| E-GEOD-3860-raw-cel-1561690392.cel | 14 | 5 | HGPS | hgu133a | none | GMO8398C |
| E-GEOD-3860-raw-cel-1561690256.cel | 6 | 5 | HGPS | hgu133a | none | GMO8398C |
