Under-expression is coded with green,
over-expression with red color.
skeletal system development
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
cell adhesion
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
nervous system development
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
biological adhesion
The attachment of a cell or organism to a substrate or other organism.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
all
This term is the most general term possible
cell adhesion
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
collagen
Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
proteinaceous extracellular matrix
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity.
collagen type IV
A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes.
basement membrane
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
sheet-forming collagen
Any collagen polymer in which collagen triple helices associate to form sheet-like networks.
extracellular matrix
A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).
extracellular matrix part
Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
This term is the most general term possible
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
extracellular matrix part
Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
collagen
Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures.
basement membrane
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
collagen type IV
A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
G-protein coupled receptor activity
A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
structural molecule activity
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.
extracellular matrix structural constituent
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
This term is the most general term possible
ABCG2ATP-binding cassette, sub-family G (WHITE), member 2 (209735_at), score: -0.65 ACANaggrecan (205679_x_at), score: -0.63 ANK3ankyrin 3, node of Ranvier (ankyrin G) (206385_s_at), score: -0.78 ANKRD1ankyrin repeat domain 1 (cardiac muscle) (206029_at), score: -0.77 ANKRD6ankyrin repeat domain 6 (204671_s_at), score: -0.65 ARHGDIBRho GDP dissociation inhibitor (GDI) beta (201288_at), score: -0.63 ARID5BAT rich interactive domain 5B (MRF1-like) (212614_at), score: -0.66 AUTS2autism susceptibility candidate 2 (212599_at), score: 0.79 BACE2beta-site APP-cleaving enzyme 2 (217867_x_at), score: 0.69 BST1bone marrow stromal cell antigen 1 (205715_at), score: -0.85 C1orf54chromosome 1 open reading frame 54 (219506_at), score: -0.8 C1QTNF3C1q and tumor necrosis factor related protein 3 (220988_s_at), score: 0.66 C5orf23chromosome 5 open reading frame 23 (219054_at), score: 0.61 C5orf30chromosome 5 open reading frame 30 (221823_at), score: 0.58 C7orf10chromosome 7 open reading frame 10 (219655_at), score: -0.69 CAMK2N1calcium/calmodulin-dependent protein kinase II inhibitor 1 (218309_at), score: 0.89 CAPGcapping protein (actin filament), gelsolin-like (201850_at), score: 0.73 CCDC81coiled-coil domain containing 81 (220389_at), score: -0.74 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: -0.68 CCR10chemokine (C-C motif) receptor 10 (220565_at), score: -0.7 CDH4cadherin 4, type 1, R-cadherin (retinal) (220227_at), score: 0.64 CHPT1choline phosphotransferase 1 (221675_s_at), score: 0.58 CLEC3BC-type lectin domain family 3, member B (205200_at), score: -0.63 CLGNcalmegin (205830_at), score: 0.59 CNIH3cornichon homolog 3 (Drosophila) (214841_at), score: 0.58 COBLL1COBL-like 1 (203642_s_at), score: -0.7 COL4A1collagen, type IV, alpha 1 (211981_at), score: -0.7 COL4A2collagen, type IV, alpha 2 (211966_at), score: -0.63 COL4A5collagen, type IV, alpha 5 (213110_s_at), score: -0.7 COL8A2collagen, type VIII, alpha 2 (221900_at), score: 0.59 COMPcartilage oligomeric matrix protein (205713_s_at), score: 0.7 CTSCcathepsin C (201487_at), score: -0.74 CYFIP2cytoplasmic FMR1 interacting protein 2 (215785_s_at), score: -0.71 CYP1B1cytochrome P450, family 1, subfamily B, polypeptide 1 (202436_s_at), score: -0.69 DMDdystrophin (203881_s_at), score: -0.71 DNM1dynamin 1 (215116_s_at), score: 0.65 EDIL3EGF-like repeats and discoidin I-like domains 3 (207379_at), score: -0.71 EIF2S3eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa (205321_at), score: -0.62 EMP2epithelial membrane protein 2 (204975_at), score: 0.59 EMX2empty spiracles homeobox 2 (221950_at), score: 0.68 ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 (205066_s_at), score: 0.78 EPHA5EPH receptor A5 (215664_s_at), score: -0.79 ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (202454_s_at), score: -0.63 F2Rcoagulation factor II (thrombin) receptor (203989_x_at), score: -0.8 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: 0.64 FHOD3formin homology 2 domain containing 3 (218980_at), score: 0.69 FOXE1forkhead box E1 (thyroid transcription factor 2) (206912_at), score: -0.76 FRMD4AFERM domain containing 4A (208476_s_at), score: -0.71 FSTfollistatin (204948_s_at), score: -0.79 FYCO1FYVE and coiled-coil domain containing 1 (218204_s_at), score: -0.63 FZD4frizzled homolog 4 (Drosophila) (218665_at), score: -0.67 GABBR2gamma-aminobutyric acid (GABA) B receptor, 2 (209990_s_at), score: 0.71 GALNT3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (203397_s_at), score: -0.71 GATA2GATA binding protein 2 (209710_at), score: 0.59 GPERG protein-coupled estrogen receptor 1 (210640_s_at), score: 0.69 GPR116G protein-coupled receptor 116 (212950_at), score: -1 GPR161G protein-coupled receptor 161 (214104_at), score: 0.59 GREM2gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis) (220794_at), score: 0.6 HDAC9histone deacetylase 9 (205659_at), score: -0.64 HMOX1heme oxygenase (decycling) 1 (203665_at), score: 0.76 HNMThistamine N-methyltransferase (204112_s_at), score: -0.68 HOXB7homeobox B7 (204779_s_at), score: 0.74 HS3ST3A1heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 (219985_at), score: 0.85 ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (208937_s_at), score: 0.58 IRX5iroquois homeobox 5 (210239_at), score: 0.59 ISLRimmunoglobulin superfamily containing leucine-rich repeat (207191_s_at), score: 0.82 ITGA8integrin, alpha 8 (214265_at), score: -0.74 JAG1jagged 1 (Alagille syndrome) (216268_s_at), score: -0.88 KALRNkalirin, RhoGEF kinase (206078_at), score: -0.77 KCNE4potassium voltage-gated channel, Isk-related family, member 4 (222379_at), score: -0.75 KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (204401_at), score: 0.69 KIAA0182KIAA0182 (212057_at), score: 0.62 KLF9Kruppel-like factor 9 (203543_s_at), score: -0.71 KRT18keratin 18 (201596_x_at), score: -0.73 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: -0.74 LGR5leucine-rich repeat-containing G protein-coupled receptor 5 (213880_at), score: -0.73 LIPGlipase, endothelial (219181_at), score: -0.62 LMO2LIM domain only 2 (rhombotin-like 1) (204249_s_at), score: -0.84 LPHN2latrophilin 2 (206953_s_at), score: -0.81 LPPR4plasticity related gene 1 (213496_at), score: -0.67 LPXNleupaxin (216250_s_at), score: 0.72 LRRC15leucine rich repeat containing 15 (213909_at), score: 0.85 LRRC17leucine rich repeat containing 17 (205381_at), score: -0.76 LRRC32leucine rich repeat containing 32 (203835_at), score: -0.71 LRRN3leucine rich repeat neuronal 3 (209841_s_at), score: -0.67 MALLmal, T-cell differentiation protein-like (209373_at), score: 0.62 MAP3K8mitogen-activated protein kinase kinase kinase 8 (205027_s_at), score: -0.63 MBPmyelin basic protein (210136_at), score: -0.87 MEOX2mesenchyme homeobox 2 (206201_s_at), score: -0.92 MESTmesoderm specific transcript homolog (mouse) (202016_at), score: -0.78 MFAP3Lmicrofibrillar-associated protein 3-like (205442_at), score: -0.66 MGPmatrix Gla protein (202291_s_at), score: -0.88 MMP14matrix metallopeptidase 14 (membrane-inserted) (202827_s_at), score: 0.63 MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (201069_at), score: 0.79 MSX1msh homeobox 1 (205932_s_at), score: 0.77 MT1Mmetallothionein 1M (217546_at), score: 0.65 MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1 (213906_at), score: 0.6 MYCT1myc target 1 (220471_s_at), score: -0.69 NBL1neuroblastoma, suppression of tumorigenicity 1 (37005_at), score: 0.71 NCAM1neural cell adhesion molecule 1 (212843_at), score: 0.63 NDNnecdin homolog (mouse) (209550_at), score: 0.68 NDUFA4L2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (218484_at), score: -0.87 NEFMneurofilament, medium polypeptide (205113_at), score: -0.75 NET1neuroepithelial cell transforming 1 (201830_s_at), score: 0.76 NID2nidogen 2 (osteonidogen) (204114_at), score: -0.7 NKX3-1NK3 homeobox 1 (209706_at), score: 0.74 NLRP1NLR family, pyrin domain containing 1 (218380_at), score: -0.63 NOVnephroblastoma overexpressed gene (214321_at), score: -0.76 NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) (219789_at), score: 0.59 NRG1neuregulin 1 (206343_s_at), score: 0.68 NRXN3neurexin 3 (205795_at), score: -0.82 OLFM1olfactomedin 1 (213131_at), score: 0.64 OLFML3olfactomedin-like 3 (218162_at), score: 0.66 PBX1pre-B-cell leukemia homeobox 1 (212148_at), score: 0.68 PDE10Aphosphodiesterase 10A (205501_at), score: -0.71 PDE4Bphosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) (203708_at), score: 0.62 PLA2G16phospholipase A2, group XVI (209581_at), score: -0.7 PLD1phospholipase D1, phosphatidylcholine-specific (215723_s_at), score: -0.66 PLXND1plexin D1 (38671_at), score: -0.69 PNMA2paraneoplastic antigen MA2 (209598_at), score: -0.81 POSTNperiostin, osteoblast specific factor (210809_s_at), score: -0.67 PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit (218292_s_at), score: -0.76 PSG5pregnancy specific beta-1-glycoprotein 5 (204830_x_at), score: 0.64 PSG9pregnancy specific beta-1-glycoprotein 9 (209594_x_at), score: 0.6 PTGER4prostaglandin E receptor 4 (subtype EP4) (204897_at), score: -0.63 PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (204469_at), score: -0.94 PTX3pentraxin-related gene, rapidly induced by IL-1 beta (206157_at), score: -0.64 RAB15RAB15, member RAS onocogene family (221810_at), score: 0.63 RELNreelin (205923_at), score: -0.89 RGS7regulator of G-protein signaling 7 (206290_s_at), score: -0.76 RTN1reticulon 1 (203485_at), score: -0.76 SCN9Asodium channel, voltage-gated, type IX, alpha subunit (206950_at), score: -0.69 SDC1syndecan 1 (201287_s_at), score: 0.6 SEPT6septin 6 (212414_s_at), score: 0.66 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: -0.64 SERPINE2serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 (212190_at), score: 0.61 SETBP1SET binding protein 1 (205933_at), score: 0.62 SFRP1secreted frizzled-related protein 1 (202036_s_at), score: 0.7 SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein) (213543_at), score: 0.73 SIGLEC15sialic acid binding Ig-like lectin 15 (215856_at), score: -0.63 SIM2single-minded homolog 2 (Drosophila) (206558_at), score: -0.62 SIRPAsignal-regulatory protein alpha (202897_at), score: 0.59 SLC1A4solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 (209610_s_at), score: -0.62 SLC24A3solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 (57588_at), score: -0.8 SLC25A4solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 (202825_at), score: -0.78 SLC6A8solute carrier family 6 (neurotransmitter transporter, creatine), member 8 (202219_at), score: 0.6 SLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (217678_at), score: -0.66 SLC7A8solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 (216092_s_at), score: 0.81 SLCO3A1solute carrier organic anion transporter family, member 3A1 (219229_at), score: 0.68 SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) (208608_s_at), score: -0.72 SOBPsine oculis binding protein homolog (Drosophila) (218974_at), score: -0.72 SOCS2suppressor of cytokine signaling 2 (203373_at), score: 0.58 SRGNserglycin (201859_at), score: -0.72 SSX2IPsynovial sarcoma, X breakpoint 2 interacting protein (203016_s_at), score: 0.7 STAT1signal transducer and activator of transcription 1, 91kDa (AFFX-HUMISGF3A/M97935_MA_at), score: -0.7 STAT4signal transducer and activator of transcription 4 (206118_at), score: -0.72 STEAP1six transmembrane epithelial antigen of the prostate 1 (205542_at), score: 0.61 STMN2stathmin-like 2 (203000_at), score: 0.75 SYNGR2synaptogyrin 2 (201079_at), score: -0.63 TCF7L1transcription factor 7-like 1 (T-cell specific, HMG-box) (221016_s_at), score: -0.7 TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) (209676_at), score: -0.73 TINAGL1tubulointerstitial nephritis antigen-like 1 (219058_x_at), score: -0.88 TMEM158transmembrane protein 158 (213338_at), score: 0.88 TMEM35transmembrane protein 35 (219685_at), score: -0.62 TNXAtenascin XA pseudogene (213451_x_at), score: -0.86 TNXBtenascin XB (216333_x_at), score: -0.87 TRIM2tripartite motif-containing 2 (202342_s_at), score: 0.59 TRPV2transient receptor potential cation channel, subfamily V, member 2 (219282_s_at), score: -0.72 TUFT1tuftelin 1 (205807_s_at), score: -0.72 UBL3ubiquitin-like 3 (201535_at), score: 0.62 WWP2WW domain containing E3 ubiquitin protein ligase 2 (204022_at), score: -0.76 ZCCHC14zinc finger, CCHC domain containing 14 (212655_at), score: 0.6 ZNF423zinc finger protein 423 (214761_at), score: -0.9 ZNF536zinc finger protein 536 (206403_at), score: 0.7
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-GEOD-3860-raw-cel-1561690336.cel | 9 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690231.cel | 4 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690432.cel | 16 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690248.cel | 5 | 5 | HGPS | hgu133a | HGPS | AG11513 |
| E-GEOD-3860-raw-cel-1561690416.cel | 15 | 5 | HGPS | hgu133a | none | GM0316B |
| E-GEOD-3860-raw-cel-1561690304.cel | 8 | 5 | HGPS | hgu133a | none | GMO8398C |
| E-GEOD-3860-raw-cel-1561690472.cel | 17 | 5 | HGPS | hgu133a | none | GM00038C |
| E-GEOD-3860-raw-cel-1561690360.cel | 12 | 5 | HGPS | hgu133a | none | GM0316B |
| E-GEOD-3860-raw-cel-1561690344.cel | 10 | 5 | HGPS | hgu133a | none | GM00038C |
| E-GEOD-3860-raw-cel-1561690392.cel | 14 | 5 | HGPS | hgu133a | none | GMO8398C |
| E-GEOD-3860-raw-cel-1561690256.cel | 6 | 5 | HGPS | hgu133a | none | GMO8398C |
| E-GEOD-3860-raw-cel-1561690223.cel | 3 | 5 | HGPS | hgu133a | none | GM00038C |
