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DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

cell cycle checkpoint

The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

DNA-dependent DNA replication

The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

response to DNA damage stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

organelle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

mitotic cell cycle spindle assembly checkpoint

A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

regulation of steroid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular component organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.

regulation of lipid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.

regulation of steroid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

spindle checkpoint

A cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and chromosomes are attached to the spindle.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

regulation of lipid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

organelle fission

The creation of two or more organelles by division of one organelle.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

regulation of lipid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

regulation of lipid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.

regulation of cellular biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

regulation of lipid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

regulation of steroid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

regulation of steroid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

regulation of steroid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.

regulation of steroid biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

mitotic cell cycle spindle assembly checkpoint

A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly).

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

chromatin

The ordered and organized complex of DNA and protein that forms the chromosome.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

protein-DNA complex

A macromolecular complex containing both protein and DNA molecules.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

all

This term is the most general term possible

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006260	4.419e-09	2.654	19 AREG, BRCA1, BRCA2, CDC7, CHAF1A, DTL, GINS1, GINS2, GINS3, HMGB2, MCM10, MCM2, MCM5, ORC6L, POLA1, POLD1, POLD3, PRIM1, RFC3	181	DNA replication
GO:0006259	8.953e-07	5.485	23 AREG, BRCA1, BRCA2, CDC7, CHAF1A, DTL, FANCG, GINS1, GINS2, GINS3, HMGB2, MCM10, MCM2, MCM5, NEIL3, ORC6L, POLA1, POLD1, POLD3, PRIM1, PSMC3IP, RAD51AP1, RFC3	374	DNA metabolic process
GO:0022403	1.308e-06	4.209	20 AURKB, BRCA2, BUB1, C18orf24, CDC7, CENPF, DSN1, IL1B, KIF11, KIF15, MAD2L1, NCAPD2, OIP5, POLA1, POLD1, PSMC3IP, SMC2, TIMELESS, TTK, WEE1	287	cell cycle phase
GO:0000279	8.434e-06	3.388	17 AURKB, BRCA2, BUB1, C18orf24, CENPF, DSN1, IL1B, KIF11, KIF15, MAD2L1, NCAPD2, OIP5, PSMC3IP, SMC2, TIMELESS, TTK, WEE1	231	M phase
GO:0000278	2.663e-05	4.62	19 AURKB, BRCA2, BUB1, C18orf24, CDC7, CENPF, DSN1, IL1B, KIF11, KIF15, MAD2L1, NCAPD2, OIP5, POLA1, POLD1, SMC2, TIMELESS, TTK, WEE1	315	mitotic cell cycle
GO:0007049	2.754e-05	9.562	28 AURKB, BMP2, BRCA1, BRCA2, BUB1, C18orf24, CDC7, CENPF, CHAF1A, CKAP2, DSN1, E2F8, FANCG, IL1B, KIF11, KIF15, MAD2L1, MCM2, MTSS1, NCAPD2, OIP5, POLA1, POLD1, PSMC3IP, SMC2, TIMELESS, TTK, WEE1	652	cell cycle
GO:0022402	4.306e-05	5.793	21 AURKB, BRCA1, BRCA2, BUB1, C18orf24, CDC7, CENPF, DSN1, IL1B, KIF11, KIF15, MAD2L1, NCAPD2, OIP5, POLA1, POLD1, PSMC3IP, SMC2, TIMELESS, TTK, WEE1	395	cell cycle process
GO:0000280	4.361e-05	2.552	14 AURKB, BUB1, C18orf24, CENPF, DSN1, IL1B, KIF11, KIF15, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, WEE1	174	nuclear division
GO:0007067	4.361e-05	2.552	14 AURKB, BUB1, C18orf24, CENPF, DSN1, IL1B, KIF11, KIF15, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, WEE1	174	mitosis
GO:0000087	5.268e-05	2.596	14 AURKB, BUB1, C18orf24, CENPF, DSN1, IL1B, KIF11, KIF15, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, WEE1	177	M phase of mitotic cell cycle
GO:0048285	6.371e-05	2.64	14 AURKB, BUB1, C18orf24, CENPF, DSN1, IL1B, KIF11, KIF15, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, WEE1	180	organelle fission
GO:0051301	1.381e-04	2.83	14 AURKB, BRCA2, BUB1, C18orf24, CDC7, CENPF, DSN1, KIF11, MAD2L1, NCAPD2, OIP5, SMC2, TIMELESS, WEE1	193	cell division
GO:0051320	2.893e-04	0.22	5 BRCA2, CDC7, POLA1, POLD1, TIMELESS	15	S phase
GO:0000731	4.772e-04	0.1173	4 POLA1, POLD1, POLD3, RFC3	8	DNA synthesis during DNA repair
GO:0008283	8.025e-04	8.286	23 AREG, BMP2, BRCA1, BRCA2, BUB1, CDC7, CENPF, FABP3, FGF1, FGF7, GINS1, HTR2A, IL1B, IL6, JARID2, KIF15, POLA1, PTHLH, SOX9, TACSTD2, TIMELESS, TTK, ZFP36L2	565	cell proliferation
GO:0006261	3.270e-03	0.8946	7 HMGB2, MCM2, MCM5, POLA1, POLD3, PRIM1, RFC3	61	DNA-dependent DNA replication
GO:0046890	3.369e-03	0.1907	4 BMP6, BRCA1, NR3C1, SEC14L2	13	regulation of lipid biosynthetic process
GO:0007094	3.544e-03	0.07333	3 BUB1, CENPF, TTK	5	mitotic cell cycle spindle assembly checkpoint
GO:0031577	3.544e-03	0.07333	3 BUB1, CENPF, TTK	5	spindle checkpoint
GO:0050810	9.620e-03	0.1027	3 BMP6, NR3C1, SEC14L2	7	regulation of steroid biosynthetic process
GO:0006974	1.065e-02	3.872	13 BRCA1, BRCA2, CHAF1A, DTL, FANCG, HMGB2, NEIL3, POLA1, POLD1, POLD3, RAD51AP1, RFC3, TIMELESS	264	response to DNA damage stimulus
GO:0034645	1.072e-02	28.98	47 AREG, ASF1B, B3GNT2, BMP2, BMP6, BRCA1, BRCA2, CDC7, CDYL, CENPF, CHAF1A, DEK, DTL, E2F8, EIF2C2, ETV5, EZH2, GINS1, GINS2, GINS3, HMGB2, HOXA10, IL1B, IL6, ITGB3BP, JARID2, MCM10, MCM2, MCM5, MLF1IP, MLXIP, NR3C1, ORC6L, POLA1, POLD1, POLD3, PRIM1, RELB, RFC3, SAP30, SEC14L2, SOX9, ST3GAL1, TIMELESS, ZNF222, ZNF395, ZNF672	1976	cellular macromolecule biosynthetic process
GO:0034961	1.122e-02	27.31	45 AREG, ASF1B, BMP2, BMP6, BRCA1, BRCA2, CDC7, CDYL, CENPF, CHAF1A, DEK, DTL, E2F8, EIF2C2, ETV5, EZH2, GINS1, GINS2, GINS3, HMGB2, HOXA10, IL1B, IL6, ITGB3BP, JARID2, MCM10, MCM2, MCM5, MLF1IP, MLXIP, NR3C1, ORC6L, POLA1, POLD1, POLD3, PRIM1, RELB, RFC3, SAP30, SEC14L2, SOX9, TIMELESS, ZNF222, ZNF395, ZNF672	1862	cellular biopolymer biosynthetic process
GO:0043284	1.122e-02	27.31	45 AREG, ASF1B, BMP2, BMP6, BRCA1, BRCA2, CDC7, CDYL, CENPF, CHAF1A, DEK, DTL, E2F8, EIF2C2, ETV5, EZH2, GINS1, GINS2, GINS3, HMGB2, HOXA10, IL1B, IL6, ITGB3BP, JARID2, MCM10, MCM2, MCM5, MLF1IP, MLXIP, NR3C1, ORC6L, POLA1, POLD1, POLD3, PRIM1, RELB, RFC3, SAP30, SEC14L2, SOX9, TIMELESS, ZNF222, ZNF395, ZNF672	1862	biopolymer biosynthetic process
GO:0009059	1.152e-02	29.08	47 AREG, ASF1B, B3GNT2, BMP2, BMP6, BRCA1, BRCA2, CDC7, CDYL, CENPF, CHAF1A, DEK, DTL, E2F8, EIF2C2, ETV5, EZH2, GINS1, GINS2, GINS3, HMGB2, HOXA10, IL1B, IL6, ITGB3BP, JARID2, MCM10, MCM2, MCM5, MLF1IP, MLXIP, NR3C1, ORC6L, POLA1, POLD1, POLD3, PRIM1, RELB, RFC3, SAP30, SEC14L2, SOX9, ST3GAL1, TIMELESS, ZNF222, ZNF395, ZNF672	1983	macromolecule biosynthetic process
GO:0019216	1.365e-02	0.528	5 BMP6, BRCA1, IL1B, NR3C1, SEC14L2	36	regulation of lipid metabolic process
GO:0006996	1.378e-02	13.14	27 ASF1B, AURKB, BRCA1, BRCA2, BUB1, C18orf24, CDYL, CENPF, CHAF1A, DSN1, EZH2, FANCG, HMGB2, IL1B, KIF11, KIF15, KIF4A, MAD2L1, MCM2, MTSS1, NCAPD2, NR3C1, OIP5, SMC2, TIMELESS, TTK, WEE1	896	organelle organization
GO:0006281	1.506e-02	2.992	11 BRCA1, BRCA2, CHAF1A, FANCG, HMGB2, NEIL3, POLA1, POLD1, POLD3, RAD51AP1, RFC3	204	DNA repair
GO:0006323	1.899e-02	0.8946	6 ASF1B, CHAF1A, HMGB2, MCM2, NCAPD2, SMC2	61	DNA packaging
GO:0006139	2.358e-02	33.77	51 AREG, ASF1B, ATP6V0A2, BMP2, BMP6, BRCA1, BRCA2, CDC7, CDYL, CENPF, CHAF1A, DEK, DTL, E2F8, ETV5, EZH2, FANCG, GINS1, GINS2, GINS3, HMGB2, HOXA10, IL1B, IL6, ITGB3BP, JARID2, MCM10, MCM2, MCM5, MLF1IP, MLXIP, NEIL3, NR3C1, ORC6L, POLA1, POLD1, POLD3, PRIM1, PSMC3IP, PTHLH, RAD51AP1, RELB, RFC3, SAP30, SEC14L2, SOX9, TIMELESS, ZFP36L2, ZNF222, ZNF395, ZNF672	2303	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
GO:0033261	2.392e-02	0.1467	3 BRCA2, CDC7, TIMELESS	10	regulation of S phase
GO:0042127	2.731e-02	5.588	15 BMP2, BRCA1, BRCA2, CDC7, FABP3, FGF1, FGF7, HTR2A, IL1B, IL6, JARID2, PTHLH, SOX9, TIMELESS, TTK	381	regulation of cell proliferation
GO:0051726	2.805e-02	3.842	12 BMP2, BRCA1, BRCA2, BUB1, CDC7, CENPF, FANCG, IL1B, MAD2L1, MTSS1, TIMELESS, TTK	262	regulation of cell cycle
GO:0051216	3.184e-02	0.3813	4 BMP2, BMP6, PTHLH, SOX9	26	cartilage development
GO:0007059	3.248e-02	0.6746	5 BRCA1, CENPF, DSN1, NCAPD2, SMC2	46	chromosome segregation
GO:0000084	3.629e-02	0.176	3 BRCA2, POLA1, POLD1	12	S phase of mitotic cell cycle
GO:0034984	3.657e-02	3.446	11 BRCA1, BRCA2, CHAF1A, FANCG, HMGB2, NEIL3, POLA1, POLD1, POLD3, RAD51AP1, RFC3	235	cellular response to DNA damage stimulus
GO:0001833	3.702e-02	0.044	2 BRCA2, GINS1	3	inner cell mass cell proliferation
GO:0006271	3.702e-02	0.044	2 POLA1, RFC3	3	DNA strand elongation during DNA replication
GO:0006289	3.728e-02	0.7039	5 BRCA2, NEIL3, POLD1, POLD3, RFC3	48	nucleotide-excision repair
GO:0031401	3.728e-02	0.7039	5 BMP2, BRCA1, IL1B, IL6, TTK	48	positive regulation of protein modification process
GO:0009058	3.895e-02	34.7	51 AREG, ASF1B, B3GNT2, BMP2, BMP6, BRCA1, BRCA2, CDC7, CDYL, CENPF, CHAF1A, DEK, DTL, E2F8, EIF2C2, ETV5, EZH2, FABP3, GFPT2, GINS1, GINS2, GINS3, HMGB2, HOXA10, IDI2, IL1B, IL6, ITGB3BP, JARID2, MCM10, MCM2, MCM5, MLF1IP, MLXIP, NR3C1, ORC6L, POLA1, POLD1, POLD3, PRIM1, PTHLH, RELB, RFC3, SAP30, SEC14L2, SOX9, ST3GAL1, TIMELESS, ZNF222, ZNF395, ZNF672	2366	biosynthetic process
GO:0001649	3.897e-02	0.4106	4 BMP2, BMP6, IL6, PTHLH	28	osteoblast differentiation
GO:0051325	4.020e-02	1.085	6 BRCA2, CDC7, CENPF, POLA1, POLD1, TIMELESS	74	interphase
GO:0022414	4.234e-02	4.106	12 ASF1B, BRCA2, CDYL, CENPI, DEK, FANCG, HOXA10, ICAM1, NR3C1, PTHLH, SOX9, THBD	280	reproductive process
GO:0007098	4.308e-02	0.1907	3 BRCA1, BRCA2, KIF11	13	centrosome cycle
GO:0019218	4.308e-02	0.1907	3 BMP6, NR3C1, SEC14L2	13	regulation of steroid metabolic process
GO:0000003	4.380e-02	4.136	12 ASF1B, BRCA2, CDYL, CENPI, DEK, FANCG, HOXA10, ICAM1, NR3C1, PTHLH, SOX9, THBD	282	reproduction
GO:0044249	4.630e-02	34.14	50 AREG, ASF1B, B3GNT2, BMP2, BMP6, BRCA1, BRCA2, CDC7, CDYL, CENPF, CHAF1A, DEK, DTL, E2F8, EIF2C2, ETV5, EZH2, FABP3, GINS1, GINS2, GINS3, HMGB2, HOXA10, IDI2, IL1B, IL6, ITGB3BP, JARID2, MCM10, MCM2, MCM5, MLF1IP, MLXIP, NR3C1, ORC6L, POLA1, POLD1, POLD3, PRIM1, PTHLH, RELB, RFC3, SAP30, SEC14L2, SOX9, ST3GAL1, TIMELESS, ZNF222, ZNF395, ZNF672	2328	cellular biosynthetic process
GO:0007093	4.639e-02	0.44	4 BUB1, CENPF, MAD2L1, TTK	30	mitotic cell cycle checkpoint
GO:0010564	4.765e-02	0.7626	5 BRCA1, BRCA2, CDC7, IL1B, TIMELESS	52	regulation of cell cycle process
GO:0000724	4.943e-02	0.2053	3 BRCA1, BRCA2, RAD51AP1	14	double-strand break repair via homologous recombination
GO:0000725	4.943e-02	0.2053	3 BRCA1, BRCA2, RAD51AP1	14	recombinational repair
GO:0045669	4.943e-02	0.2053	3 BMP2, BMP6, IL6	14	positive regulation of osteoblast differentiation

Id	Pvalue	ExpCount	Count	Size	Term
GO:0044427	1.483e-11	2.947	22 ASF1B, AURKB, BUB1, C18orf24, CDYL, CENPF, CENPI, CENPM, DSN1, ITGB3BP, MAD2L1, MCM2, MLF1IP, NCAPD2, OIP5, ORC6L, POLA1, POLD3, PRIM1, RFC3, SMC2, TIMELESS	198	chromosomal part
GO:0005694	2.092e-11	3.691	24 ASF1B, AURKB, BRCA1, BUB1, C18orf24, CDYL, CENPF, CENPI, CENPM, DSN1, HMGB2, ITGB3BP, MAD2L1, MCM2, MLF1IP, NCAPD2, OIP5, ORC6L, POLA1, POLD3, PRIM1, RFC3, SMC2, TIMELESS	248	chromosome
GO:0000775	1.517e-07	0.9377	11 AURKB, BUB1, C18orf24, CENPF, CENPI, CENPM, DSN1, ITGB3BP, MAD2L1, MLF1IP, OIP5	63	chromosome, centromeric region
GO:0000793	2.917e-06	0.9823	10 BRCA1, BUB1, C18orf24, CENPF, CENPM, DSN1, HMGB2, MLF1IP, NCAPD2, SMC2	66	condensed chromosome
GO:0000228	1.183e-05	1.146	10 BUB1, HMGB2, MCM2, NCAPD2, ORC6L, POLA1, POLD3, PRIM1, SMC2, TIMELESS	77	nuclear chromosome
GO:0000776	2.317e-04	0.6847	7 BUB1, C18orf24, CENPF, CENPM, DSN1, MAD2L1, MLF1IP	46	kinetochore
GO:0043228	2.893e-04	20.09	40 ANGPTL4, ASF1B, AURKB, BRCA1, BRCA2, BUB1, C18orf24, CDYL, CENPF, CENPI, CENPM, CKAP2, DSN1, FERMT1, HMGB2, ITGB3BP, KIF11, KIF15, KIF18B, KIF4A, LMNB1, MAD2L1, MCM2, MLF1IP, MTSS1, MYBL1, NCAPD2, NR3C1, OIP5, ORC6L, POLA1, POLD3, PRIM1, RFC3, SMC2, SOX9, TIMELESS, TOM1, TTK, VCL	1350	non-membrane-bounded organelle
GO:0043232	2.893e-04	20.09	40 ANGPTL4, ASF1B, AURKB, BRCA1, BRCA2, BUB1, C18orf24, CDYL, CENPF, CENPI, CENPM, CKAP2, DSN1, FERMT1, HMGB2, ITGB3BP, KIF11, KIF15, KIF18B, KIF4A, LMNB1, MAD2L1, MCM2, MLF1IP, MTSS1, MYBL1, NCAPD2, NR3C1, OIP5, ORC6L, POLA1, POLD3, PRIM1, RFC3, SMC2, SOX9, TIMELESS, TOM1, TTK, VCL	1350	intracellular non-membrane-bounded organelle
GO:0000777	4.352e-04	0.5061	6 BUB1, C18orf24, CENPF, CENPM, DSN1, MLF1IP	34	condensed chromosome kinetochore
GO:0000779	4.352e-04	0.5061	6 BUB1, C18orf24, CENPF, CENPM, DSN1, MLF1IP	34	condensed chromosome, centromeric region
GO:0044454	8.468e-04	0.8484	7 BUB1, MCM2, ORC6L, POLA1, POLD3, PRIM1, TIMELESS	57	nuclear chromosome part
GO:0005819	9.708e-04	1.191	8 AURKB, BUB1, C18orf24, CENPF, KIF11, KIF15, KIF4A, TTK	80	spindle
GO:0005634	4.415e-03	46.01	66 ANGPTL4, ASF1B, AURKB, BRCA1, BRCA2, BUB1, CCNJ, CDC7, CDYL, CENPF, CENPI, CENPM, CHAF1A, CPA3, DEK, DEPDC1, DSN1, DTL, E2F8, ETV5, EZH2, FANCG, GINS1, GINS2, GINS3, HJURP, HMGB2, HOXA10, ITGB3BP, JARID2, KIF11, KIF4A, LMNB1, MAD2L1, MCM10, MCM2, MCM5, MDM1, MLF1IP, MLXIP, MYBL1, NCAPD2, NEIL3, NR3C1, OIP5, ORC6L, POLA1, POLD1, POLD3, PRIM1, PSMC3IP, PTHLH, RAD51AP1, RELB, RFC3, SAP30, SEC14L2, SMC2, SOX9, TIMELESS, TRAF4, WEE1, ZFP36L2, ZNF222, ZNF395, ZNF672	3091	nucleus
GO:0030894	7.923e-03	0.134	3 POLA1, POLD3, PRIM1	9	replisome
GO:0043601	7.923e-03	0.134	3 POLA1, POLD3, PRIM1	9	nuclear replisome
GO:0000785	9.659e-03	1.31	7 ASF1B, CDYL, CENPF, MCM2, OIP5, POLA1, TIMELESS	88	chromatin
GO:0031981	9.945e-03	12.87	26 ANGPTL4, BRCA1, BRCA2, CDC7, CENPF, CHAF1A, E2F8, EZH2, HMGB2, KIF4A, LMNB1, MCM10, MCM2, MCM5, MYBL1, NR3C1, OIP5, ORC6L, POLA1, POLD1, POLD3, PRIM1, RFC3, SAP30, SOX9, WEE1	865	nuclear lumen
GO:0044428	1.237e-02	16.88	31 ANGPTL4, BRCA1, BRCA2, BUB1, CDC7, CENPF, CHAF1A, DTL, E2F8, EZH2, HMGB2, KIF4A, LMNB1, MCM10, MCM2, MCM5, MYBL1, NCAPD2, NR3C1, OIP5, ORC6L, POLA1, POLD1, POLD3, PRIM1, RFC3, SAP30, SMC2, SOX9, TIMELESS, WEE1	1134	nuclear part
GO:0043596	1.400e-02	0.1637	3 POLA1, POLD3, PRIM1	11	nuclear replication fork
GO:0005657	1.534e-02	0.387	4 POLA1, POLD3, PRIM1, RFC3	26	replication fork
GO:0015630	2.467e-02	4.793	13 AURKB, BRCA1, BRCA2, BUB1, C18orf24, CENPF, CKAP2, KIF11, KIF15, KIF18B, KIF4A, TOM1, TTK	322	microtubule cytoskeleton
GO:0005664	3.158e-02	0.05954	2 MCM2, ORC6L	4	nuclear origin of replication recognition complex
GO:0005654	4.112e-02	8.484	18 BRCA1, BRCA2, CDC7, CHAF1A, E2F8, EZH2, MCM10, MCM2, MCM5, OIP5, ORC6L, POLA1, POLD1, POLD3, PRIM1, RFC3, SAP30, WEE1	570	nucleoplasm
GO:0000808	4.719e-02	0.07442	2 MCM2, ORC6L	5	origin recognition complex
GO:0005658	4.719e-02	0.07442	2 POLA1, PRIM1	5	alpha DNA polymerase:primase complex
GO:0043234	4.785e-02	17.79	30 ATP6V0A2, BRCA1, BRCA2, BUB1, C18orf24, CENPF, CENPM, CHAF1A, DSN1, E2F8, EZH2, IL6, KCNG1, KIF11, KIF15, KIF18B, KIF4A, MAD2L1, MCM2, MLF1IP, NCAPD2, ORC6L, PIK3CD, POLA1, POLD3, PRIM1, RFC3, SAP30, SMC2, VCL	1195	protein complex

Id	Pvalue	ExpCount	Count	Size	Term
GO:0003677	1.404e-02	17.37	33 BRCA1, BRCA2, DEK, E2F8, ETV5, EZH2, FANCG, HJURP, HMGB2, HOXA10, JARID2, KIF15, KIF4A, MCM2, MCM5, MLXIP, MYBL1, NEIL3, NR3C1, ORC6L, POLA1, POLD1, PSMC3IP, RAD51AP1, RELB, RFC3, SOX9, TRAF4, ZBED4, ZFP36L2, ZNF222, ZNF395, ZNF672	1210	DNA binding
GO:0008083	3.206e-02	1.349	7 AREG, BMP2, BMP6, FGF1, FGF7, IL1B, IL6	94	growth factor activity
GO:0003896	4.392e-02	0.04307	2 POLA1, PRIM1	3	DNA primase activity

Id	Pvalue	ExpCount	Count	Size	Term
03030	1.498e-04	0.5569	7 MCM2, MCM5, POLA1, POLD1, POLD3, PRIM1, RFC3	33	DNA replication

No enriched terms

No enriched terms

Entrez genes

ANGPTL4angiopoietin-like 4 (221009_s_at), score: -0.76 AQP3aquaporin 3 (Gill blood group) (39248_at), score: -0.69 AREGamphiregulin (205239_at), score: -0.93 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: -0.7 ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae) (218115_at), score: 0.63 ATP6V0A2ATPase, H+ transporting, lysosomal V0 subunit a2 (205704_s_at), score: -0.7 AURKBaurora kinase B (209464_at), score: 0.62 B3GNT2UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (219326_s_at), score: -0.84 BCL2A1BCL2-related protein A1 (205681_at), score: -0.71 BMP2bone morphogenetic protein 2 (205289_at), score: -0.95 BMP6bone morphogenetic protein 6 (206176_at), score: -0.91 BRCA1breast cancer 1, early onset (204531_s_at), score: 0.6 BRCA2breast cancer 2, early onset (208368_s_at), score: 0.62 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: 0.6 C17orf91chromosome 17 open reading frame 91 (214696_at), score: -0.77 C18orf24chromosome 18 open reading frame 24 (217640_x_at), score: 0.65 CBR3carbonyl reductase 3 (205379_at), score: 0.71 CCNJcyclin J (219470_x_at), score: -0.69 CDC7cell division cycle 7 homolog (S. cerevisiae) (204510_at), score: 0.65 CDYLchromodomain protein, Y-like (203100_s_at), score: -0.71 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: 0.61 CENPIcentromere protein I (214804_at), score: 0.65 CENPMcentromere protein M (218741_at), score: 0.64 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: 0.61 CHMP1Bchromatin modifying protein 1B (218178_s_at), score: -0.65 CKAP2cytoskeleton associated protein 2 (218252_at), score: 0.65 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: -0.65 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: -0.72 DEKDEK oncogene (200934_at), score: 0.6 DEPDC1DEP domain containing 1 (220295_x_at), score: 0.61 DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (219512_at), score: 0.63 DTLdenticleless homolog (Drosophila) (218585_s_at), score: 0.6 E2F8E2F transcription factor 8 (219990_at), score: 0.65 EIF2C2eukaryotic translation initiation factor 2C, 2 (213310_at), score: -0.69 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: -0.98 ETV5ets variant 5 (203349_s_at), score: 0.63 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: 0.67 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: -0.67 FANCGFanconi anemia, complementation group G (203564_at), score: 0.6 FERMT1fermitin family homolog 1 (Drosophila) (218796_at), score: -0.66 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: -0.73 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: -0.71 GALNT4UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) (220442_at), score: -0.78 GFPT2glutamine-fructose-6-phosphate transaminase 2 (205100_at), score: -0.81 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: 0.61 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: 0.63 GINS3GINS complex subunit 3 (Psf3 homolog) (45633_at), score: 0.62 GPR183G protein-coupled receptor 183 (205419_at), score: -1 HJURPHolliday junction recognition protein (218726_at), score: 0.6 HMGB2high-mobility group box 2 (208808_s_at), score: 0.69 HMMRhyaluronan-mediated motility receptor (RHAMM) (207165_at), score: 0.62 HOXA10homeobox A10 (213150_at), score: 0.65 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: -0.81 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: -0.78 IDI2isopentenyl-diphosphate delta isomerase 2 (217631_at), score: -0.66 IL1Binterleukin 1, beta (39402_at), score: -0.8 IL6interleukin 6 (interferon, beta 2) (205207_at), score: -0.67 IRGQimmunity-related GTPase family, Q (64488_at), score: -0.7 ITGB3BPintegrin beta 3 binding protein (beta3-endonexin) (205176_s_at), score: 0.64 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: -0.69 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: -0.69 KCNG1potassium voltage-gated channel, subfamily G, member 1 (214595_at), score: -0.82 KIF11kinesin family member 11 (204444_at), score: 0.63 KIF15kinesin family member 15 (219306_at), score: 0.61 KIF18Bkinesin family member 18B (222039_at), score: 0.65 KIF4Akinesin family member 4A (218355_at), score: 0.62 LAMC2laminin, gamma 2 (202267_at), score: -0.82 LMNB1lamin B1 (203276_at), score: 0.6 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: 0.61 MBOAT2membrane bound O-acyltransferase domain containing 2 (213288_at), score: -0.71 MCM10minichromosome maintenance complex component 10 (220651_s_at), score: 0.64 MCM2minichromosome maintenance complex component 2 (202107_s_at), score: 0.62 MCM5minichromosome maintenance complex component 5 (216237_s_at), score: 0.62 MDM1Mdm1 nuclear protein homolog (mouse) (213761_at), score: 0.61 MFAP3microfibrillar-associated protein 3 (213123_at), score: -0.67 MLF1IPMLF1 interacting protein (218883_s_at), score: 0.62 MLXIPMLX interacting protein (202519_at), score: -0.69 MREGmelanoregulin (219648_at), score: -0.66 MTMR9myotubularin related protein 9 (204837_at), score: -0.68 MTSS1metastasis suppressor 1 (203037_s_at), score: -0.71 MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1 (213906_at), score: 0.63 NCAPD2non-SMC condensin I complex, subunit D2 (201774_s_at), score: 0.6 NEIL3nei endonuclease VIII-like 3 (E. coli) (219502_at), score: 0.6 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: -0.66 NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae) (219067_s_at), score: 0.61 OIP5Opa interacting protein 5 (213599_at), score: 0.62 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: 0.6 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: -0.8 PLCXD1phosphatidylinositol-specific phospholipase C, X domain containing 1 (218951_s_at), score: -0.65 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: -0.81 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: 0.66 POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa (203422_at), score: 0.63 POLD3polymerase (DNA-directed), delta 3, accessory subunit (212836_at), score: 0.63 PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (207000_s_at), score: -0.73 PRIM1primase, DNA, polypeptide 1 (49kDa) (205053_at), score: 0.67 PSMC3IPPSMC3 interacting protein (213951_s_at), score: 0.6 PTHLHparathyroid hormone-like hormone (211756_at), score: -0.91 RAD51AP1RAD51 associated protein 1 (204146_at), score: 0.6 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: -0.81 RELBv-rel reticuloendotheliosis viral oncogene homolog B (205205_at), score: -0.65 RFC3replication factor C (activator 1) 3, 38kDa (204127_at), score: 0.63 SAP30Sin3A-associated protein, 30kDa (204900_x_at), score: 0.61 SEC14L2SEC14-like 2 (S. cerevisiae) (204541_at), score: -0.67 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: -0.69 SMC2structural maintenance of chromosomes 2 (204240_s_at), score: 0.6 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: -0.73 SPATA2Lspermatogenesis associated 2-like (214965_at), score: -0.68 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: -0.69 STK38Lserine/threonine kinase 38 like (212572_at), score: -0.75 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: -0.74 THBDthrombomodulin (203887_s_at), score: -0.78 TIMELESStimeless homolog (Drosophila) (203046_s_at), score: 0.61 TMEM194Atransmembrane protein 194A (212621_at), score: 0.7 TOM1target of myb1 (chicken) (202807_s_at), score: -0.67 TRAF4TNF receptor-associated factor 4 (202871_at), score: -0.66 TRPC6transient receptor potential cation channel, subfamily C, member 6 (217287_s_at), score: -0.78 TTC17tetratricopeptide repeat domain 17 (218972_at), score: -0.78 TTKTTK protein kinase (204822_at), score: 0.66 VCLvinculin (200930_s_at), score: -0.69 WEE1WEE1 homolog (S. pombe) (212533_at), score: 0.76 YRDCyrdC domain containing (E. coli) (218647_s_at), score: -0.78 ZBED4zinc finger, BED-type containing 4 (204799_at), score: -0.68 ZFP36L2zinc finger protein 36, C3H type-like 2 (201367_s_at), score: 0.64 ZNF222zinc finger protein 222 (206175_x_at), score: -0.69 ZNF395zinc finger protein 395 (218149_s_at), score: 0.66 ZNF672zinc finger protein 672 (218068_s_at), score: -0.74

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
E-TABM-263-raw-cel-1515485851.cel	11	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486351.cel	36	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486231.cel	30	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485811.cel	9	6	Cycle	hgu133a2	none	Cycle 1