Under-expression is coded with green,
over-expression with red color.
blood vessel development
The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
vasculature development
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell surface receptor linked signal transduction
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
all
This term is the most general term possible
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
intermediate filament cytoskeleton
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
neurofilament cytoskeleton
Intermediate filament cytoskeletal structure that is made up of neurofilaments. Neurofilaments are specialized intermediate filaments found in neurons.
all
This term is the most general term possible
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
calcium ion binding
Interacting selectively with calcium ions (Ca2+).
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
metal ion binding
Interacting selectively with any metal ion.
ion binding
Interacting selectively with ions, charged atoms or groups of atoms.
cation binding
Interacting selectively with cations, charged atoms or groups of atoms with a net positive charge.
all
This term is the most general term possible
calcium ion binding
Interacting selectively with calcium ions (Ca2+).
ABCA8ATP-binding cassette, sub-family A (ABC1), member 8 (204719_at), score: 0.72 ABCG2ATP-binding cassette, sub-family G (WHITE), member 2 (209735_at), score: -0.81 ADAMTSL3ADAMTS-like 3 (213974_at), score: 0.68 AGTR1angiotensin II receptor, type 1 (205357_s_at), score: -0.7 ANK3ankyrin 3, node of Ranvier (ankyrin G) (206385_s_at), score: -0.78 ANKRD6ankyrin repeat domain 6 (204671_s_at), score: -0.78 ANO3anoctamin 3 (215241_at), score: -0.68 ANXA3annexin A3 (209369_at), score: 0.71 AQP1aquaporin 1 (Colton blood group) (209047_at), score: -0.7 ARHGAP29Rho GTPase activating protein 29 (203910_at), score: 0.8 ATF3activating transcription factor 3 (202672_s_at), score: -0.77 BNC2basonuclin 2 (220272_at), score: 0.77 C8orf84chromosome 8 open reading frame 84 (214725_at), score: 0.68 CARHSP1calcium regulated heat stable protein 1, 24kDa (218384_at), score: 0.75 CCDC81coiled-coil domain containing 81 (220389_at), score: -0.75 CCDC92coiled-coil domain containing 92 (218175_at), score: -0.69 CD200CD200 molecule (209583_s_at), score: 0.73 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: 0.88 CFHcomplement factor H (213800_at), score: 0.7 CFHR1complement factor H-related 1 (215388_s_at), score: 0.7 CHRDL1chordin-like 1 (209763_at), score: 0.73 CORINcorin, serine peptidase (220356_at), score: -0.82 CUGBP2CUG triplet repeat, RNA binding protein 2 (202158_s_at), score: 0.75 CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (204470_at), score: 0.71 CYB5Acytochrome b5 type A (microsomal) (215726_s_at), score: 0.72 CYFIP2cytoplasmic FMR1 interacting protein 2 (215785_s_at), score: -0.8 DAAM2dishevelled associated activator of morphogenesis 2 (212793_at), score: -0.74 DPYSL3dihydropyrimidinase-like 3 (201430_s_at), score: 0.8 DSG2desmoglein 2 (217901_at), score: 0.77 EDN1endothelin 1 (218995_s_at), score: 0.68 EFHD1EF-hand domain family, member D1 (209343_at), score: -0.83 EN1engrailed homeobox 1 (220559_at), score: -0.77 ENPEPglutamyl aminopeptidase (aminopeptidase A) (204844_at), score: -0.76 EREGepiregulin (205767_at), score: -0.69 FBLN1fibulin 1 (202995_s_at), score: 0.69 FBLN2fibulin 2 (203886_s_at), score: -0.78 FGL2fibrinogen-like 2 (204834_at), score: 0.8 FOXE1forkhead box E1 (thyroid transcription factor 2) (206912_at), score: -0.72 FOXO1forkhead box O1 (202724_s_at), score: 0.7 FUT8fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (203988_s_at), score: 0.76 GPR116G protein-coupled receptor 116 (212950_at), score: -1 GPR126G protein-coupled receptor 126 (213094_at), score: 0.72 GPR4G protein-coupled receptor 4 (206236_at), score: 0.76 GPRC5BG protein-coupled receptor, family C, group 5, member B (203632_s_at), score: 0.7 HCLS1hematopoietic cell-specific Lyn substrate 1 (202957_at), score: -0.76 HNMThistamine N-methyltransferase (204112_s_at), score: -0.7 HOXB7homeobox B7 (204779_s_at), score: 0.71 HRH1histamine receptor H1 (205579_at), score: 0.73 HSPB8heat shock 22kDa protein 8 (221667_s_at), score: -0.76 ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (208937_s_at), score: 0.7 IFI27interferon, alpha-inducible protein 27 (202411_at), score: 0.68 INAinternexin neuronal intermediate filament protein, alpha (204465_s_at), score: -0.67 ITGA7integrin, alpha 7 (216331_at), score: -0.74 ITGA8integrin, alpha 8 (214265_at), score: -0.94 KCND2potassium voltage-gated channel, Shal-related subfamily, member 2 (207103_at), score: -0.81 KCNE4potassium voltage-gated channel, Isk-related family, member 4 (222379_at), score: -0.68 KCTD12potassium channel tetramerisation domain containing 12 (212192_at), score: 0.83 KLF5Kruppel-like factor 5 (intestinal) (209212_s_at), score: 0.76 LAMA4laminin, alpha 4 (202202_s_at), score: 0.9 LAMC2laminin, gamma 2 (202267_at), score: 0.72 LGR5leucine-rich repeat-containing G protein-coupled receptor 5 (213880_at), score: -0.86 LIMCH1LIM and calponin homology domains 1 (212327_at), score: 0.71 LIPGlipase, endothelial (219181_at), score: 0.75 LPPR4plasticity related gene 1 (213496_at), score: -0.8 MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (201069_at), score: 0.77 MYH10myosin, heavy chain 10, non-muscle (212372_at), score: 0.88 MYLKmyosin light chain kinase (202555_s_at), score: -0.71 NAP1L3nucleosome assembly protein 1-like 3 (204749_at), score: 0.71 NEFMneurofilament, medium polypeptide (205113_at), score: -0.8 NFIBnuclear factor I/B (209289_at), score: 0.72 NOX4NADPH oxidase 4 (219773_at), score: 0.78 PARP3poly (ADP-ribose) polymerase family, member 3 (209940_at), score: -0.8 PDLIM3PDZ and LIM domain 3 (209621_s_at), score: -0.78 PHF11PHD finger protein 11 (221816_s_at), score: -0.69 PLK2polo-like kinase 2 (Drosophila) (201939_at), score: 0.74 PLXNA2plexin A2 (213030_s_at), score: 0.82 PORCNporcupine homolog (Drosophila) (219483_s_at), score: -0.82 PPAP2Aphosphatidic acid phosphatase type 2A (209147_s_at), score: -0.69 PPP1R13Lprotein phosphatase 1, regulatory (inhibitor) subunit 13 like (218849_s_at), score: 0.77 PRSS1protease, serine, 1 (trypsin 1) (216470_x_at), score: -0.75 PRSS2protease, serine, 2 (trypsin 2) (205402_x_at), score: -0.75 PRSS3protease, serine, 3 (207463_x_at), score: -0.86 PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (204469_at), score: -0.98 RHBDL2rhomboid, veinlet-like 2 (Drosophila) (219489_s_at), score: 0.76 RPP25ribonuclease P/MRP 25kDa subunit (219143_s_at), score: -0.85 RTN1reticulon 1 (203485_at), score: -0.92 SCN3Asodium channel, voltage-gated, type III, alpha subunit (210432_s_at), score: -0.78 SEPT6septin 6 (212414_s_at), score: 0.69 SIGLEC15sialic acid binding Ig-like lectin 15 (215856_at), score: -0.73 SIM2single-minded homolog 2 (Drosophila) (206558_at), score: -0.86 SIX2SIX homeobox 2 (206510_at), score: -0.71 SLC17A9solute carrier family 17, member 9 (219559_at), score: -0.72 SLC24A3solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 (57588_at), score: -0.87 SLC7A5solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 (201195_s_at), score: 0.75 SMAD6SMAD family member 6 (207069_s_at), score: 0.7 SORBS2sorbin and SH3 domain containing 2 (204288_s_at), score: -0.71 SOX17SRY (sex determining region Y)-box 17 (219993_at), score: 0.74 SPP1secreted phosphoprotein 1 (209875_s_at), score: -0.78 STBD1starch binding domain 1 (203986_at), score: -0.7 SYNMsynemin, intermediate filament protein (212730_at), score: -0.72 TBXA2Rthromboxane A2 receptor (336_at), score: -0.8 TEAD3TEA domain family member 3 (209454_s_at), score: -0.74 TIMP3TIMP metallopeptidase inhibitor 3 (201149_s_at), score: -0.71 TRIM34tripartite motif-containing 34 (221044_s_at), score: -0.73 TRPV2transient receptor potential cation channel, subfamily V, member 2 (219282_s_at), score: -0.72 TRY6trypsinogen C (215395_x_at), score: -0.83 TSPAN12tetraspanin 12 (219274_at), score: -0.68 TSPYL5TSPY-like 5 (213122_at), score: 0.78 UAP1L1UDP-N-acteylglucosamine pyrophosphorylase 1-like 1 (214755_at), score: -0.73 VAMP8vesicle-associated membrane protein 8 (endobrevin) (202546_at), score: -0.83 ZEB2zinc finger E-box binding homeobox 2 (203603_s_at), score: -0.69 ZFHX4zinc finger homeobox 4 (219779_at), score: 0.84 ZFPM2zinc finger protein, multitype 2 (219778_at), score: 0.69 ZNF365zinc finger protein 365 (206448_at), score: 0.68
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-GEOD-3860-raw-cel-1561690336.cel | 9 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690231.cel | 4 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690432.cel | 16 | 5 | HGPS | hgu133a | HGPS | AG10750 |
| E-GEOD-3860-raw-cel-1561690352.cel | 11 | 5 | HGPS | hgu133a | HGPS | AG11498 |
| E-GEOD-3860-raw-cel-1561690272.cel | 7 | 5 | HGPS | hgu133a | HGPS | AG11498 |
| E-GEOD-3860-raw-cel-1561690480.cel | 18 | 5 | HGPS | hgu133a | HGPS | AG11498 |
