Under-expression is coded with green,
over-expression with red color.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell surface receptor linked signal transduction
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
G-protein coupled receptor protein signaling pathway
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
all
This term is the most general term possible
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
This term is the most general term possible
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
protein binding
Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
peptide receptor activity
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
G-protein coupled receptor activity
A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
MAP-kinase scaffold activity
Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins.
structural molecule activity
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
receptor signaling complex scaffold activity
Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.
protein complex scaffold
Functions to provide a physical support for the assembly of a multiprotein complex.
peptide binding
Interacting selectively with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
This term is the most general term possible
protein complex scaffold
Functions to provide a physical support for the assembly of a multiprotein complex.
peptide receptor activity
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 04080 | 1.509e-02 | 0.883 | 6 | 83 | Neuroactive ligand-receptor interaction |
ABCG4ATP-binding cassette, sub-family G (WHITE), member 4 (207593_at), score: 0.66 ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif, 7 (220705_s_at), score: 0.68 ADORA1adenosine A1 receptor (216220_s_at), score: 0.77 ADRA1Dadrenergic, alpha-1D-, receptor (210961_s_at), score: 0.71 BRS3bombesin-like receptor 3 (207369_at), score: 0.8 BTNL3butyrophilin-like 3 (217207_s_at), score: 0.67 C7orf28Achromosome 7 open reading frame 28A (201974_s_at), score: 0.77 CA4carbonic anhydrase IV (206209_s_at), score: 0.69 CATSPER2cation channel, sperm associated 2 (217588_at), score: 0.75 CCDC9coiled-coil domain containing 9 (206257_at), score: 0.74 CD53CD53 molecule (203416_at), score: 0.75 CFHR2complement factor H-related 2 (206910_x_at), score: 0.72 COL11A2collagen, type XI, alpha 2 (216993_s_at), score: 0.71 CXCL10chemokine (C-X-C motif) ligand 10 (204533_at), score: 0.71 CXorf21chromosome X open reading frame 21 (220252_x_at), score: 0.65 CYBBcytochrome b-245, beta polypeptide (203923_s_at), score: 0.92 CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 4 (205998_x_at), score: 0.73 DHRS9dehydrogenase/reductase (SDR family) member 9 (219799_s_at), score: 0.69 DRD5dopamine receptor D5 (208486_at), score: 0.66 EDAectodysplasin A (211130_x_at), score: 1 ETNK2ethanolamine kinase 2 (219268_at), score: 0.66 F11coagulation factor XI (206610_s_at), score: 0.76 FBRSfibrosin (218255_s_at), score: 0.82 FGL1fibrinogen-like 1 (205305_at), score: 0.74 FKBP10FK506 binding protein 10, 65 kDa (219249_s_at), score: 0.73 GLTSCR1glioma tumor suppressor candidate region gene 1 (219445_at), score: 0.65 GP1BAglycoprotein Ib (platelet), alpha polypeptide (207389_at), score: 0.67 GPATCH4G patch domain containing 4 (220596_at), score: 0.7 GPR32G protein-coupled receptor 32 (221469_at), score: 0.7 HAB1B1 for mucin (215778_x_at), score: 0.8 HAND1heart and neural crest derivatives expressed 1 (220138_at), score: 0.75 HAO2hydroxyacid oxidase 2 (long chain) (220801_s_at), score: 0.65 IGLL3immunoglobulin lambda-like polypeptide 3 (215946_x_at), score: 0.65 INE1inactivation escape 1 (non-protein coding) (207252_at), score: 0.69 ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) (213475_s_at), score: 0.66 LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 (215838_at), score: 0.7 LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 (211133_x_at), score: 0.74 LOC149478hypothetical protein LOC149478 (215462_at), score: 0.69 LOC23117PI-3-kinase-related kinase SMG-1 isoform 1 homolog (211996_s_at), score: 0.69 LOC643293FLJ44451 pseudogene (215057_at), score: 0.72 LOC80054hypothetical LOC80054 (220465_at), score: 0.7 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: 0.69 LONRF3LON peptidase N-terminal domain and ring finger 3 (220009_at), score: 0.73 LPAR4lysophosphatidic acid receptor 4 (206960_at), score: 0.67 LRRN2leucine rich repeat neuronal 2 (216164_at), score: 0.71 MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1 (213013_at), score: 0.78 MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2 (205050_s_at), score: 0.81 MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (203936_s_at), score: 0.65 MMRN2multimerin 2 (219091_s_at), score: 0.68 MOBPmyelin-associated oligodendrocyte basic protein (210193_at), score: 0.75 MSTP9macrophage stimulating, pseudogene 9 (213382_at), score: 0.68 MYL4myosin, light chain 4, alkali; atrial, embryonic (210088_x_at), score: 0.74 MYO1Amyosin IA (211916_s_at), score: 0.84 NCRNA00092non-protein coding RNA 92 (215861_at), score: 0.69 OR1E2olfactory receptor, family 1, subfamily E, member 2 (208587_s_at), score: 0.75 OR7E24olfactory receptor, family 7, subfamily E, member 24 (215463_at), score: 0.78 PGCprogastricsin (pepsinogen C) (205261_at), score: 0.75 PIPOXpipecolic acid oxidase (221605_s_at), score: 0.9 PNPLA2patatin-like phospholipase domain containing 2 (212705_x_at), score: 0.71 PRSS7protease, serine, 7 (enterokinase) (217269_s_at), score: 0.93 PYHIN1pyrin and HIN domain family, member 1 (216748_at), score: 0.86 RPGRIP1retinitis pigmentosa GTPase regulator interacting protein 1 (206608_s_at), score: 0.7 S100A14S100 calcium binding protein A14 (218677_at), score: 0.71 SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (207185_at), score: 0.7 SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2 (208389_s_at), score: 0.65 SLC26A10solute carrier family 26, member 10 (214951_at), score: 0.73 SLCO2A1solute carrier organic anion transporter family, member 2A1 (204368_at), score: 0.66 SOCS3suppressor of cytokine signaling 3 (206359_at), score: 0.64 ST6GAL1ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 (201998_at), score: 0.87 ST8SIA3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 (208064_s_at), score: 0.72 TACR1tachykinin receptor 1 (208048_at), score: 0.74 TBX21T-box 21 (220684_at), score: 0.74 TBX6T-box 6 (207684_at), score: 0.73 TMSB4Ythymosin beta 4, Y-linked (206769_at), score: 0.83 TULP2tubby like protein 2 (206733_at), score: 0.78 VGFVGF nerve growth factor inducible (205586_x_at), score: 0.89
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-TABM-263-raw-cel-1515485651.cel | 1 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485951.cel | 16 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485711.cel | 4 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486111.cel | 24 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486131.cel | 25 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| t21d 08-03.CEL | 7 | 1 | DS-CC | hgu133a | Down | DS-CC 7 |
| E-TABM-263-raw-cel-1515485931.cel | 15 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| t21a 08-03.CEL | 4 | 1 | DS-CC | hgu133a | Down | DS-CC 4 |
| ctrl a 08-03.CEL | 1 | 1 | DS-CC | hgu133a | none | DS-CC 1 |
