Under-expression is coded with green,
over-expression with red color.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell surface receptor linked signal transduction
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
G-protein coupled receptor protein signaling pathway
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
all
This term is the most general term possible
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
signal transduction
The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
This term is the most general term possible
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
G-protein coupled receptor activity
A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
neurotransmitter receptor activity
Combining with a neurotransmitter to initiate a change in cell activity.
neurotransmitter binding
Interacting selectively with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
This term is the most general term possible
neurotransmitter receptor activity
Combining with a neurotransmitter to initiate a change in cell activity.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 04080 | 1.964e-03 | 1.187 | 8 | 83 | Neuroactive ligand-receptor interaction |
ABCG4ATP-binding cassette, sub-family G (WHITE), member 4 (207593_at), score: -0.69 ACSL6acyl-CoA synthetase long-chain family member 6 (211207_s_at), score: -0.89 ADAMDEC1ADAM-like, decysin 1 (206134_at), score: -0.83 ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif, 9 (220287_at), score: -0.85 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (207102_at), score: -0.69 BEANbrain expressed, associated with Nedd4 (214068_at), score: -0.69 BMP10bone morphogenetic protein 10 (208292_at), score: -0.72 BRS3bombesin-like receptor 3 (207369_at), score: -0.78 BTNL3butyrophilin-like 3 (217207_s_at), score: -0.64 C3orf51chromosome 3 open reading frame 51 (208247_at), score: -0.63 C7orf28Achromosome 7 open reading frame 28A (201974_s_at), score: -0.6 C8orf60chromosome 8 open reading frame 60 (220712_at), score: -0.59 CCDC9coiled-coil domain containing 9 (206257_at), score: -0.77 CD28CD28 molecule (206545_at), score: -0.68 CDH19cadherin 19, type 2 (206898_at), score: -0.95 CEACAM5carcinoembryonic antigen-related cell adhesion molecule 5 (201884_at), score: -0.64 CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (211657_at), score: -0.83 CHN2chimerin (chimaerin) 2 (207486_x_at), score: -0.84 CHRNA9cholinergic receptor, nicotinic, alpha 9 (221107_at), score: -0.57 CHST4carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 (220446_s_at), score: -0.58 CLDN10claudin 10 (205328_at), score: -0.78 CLEC2DC-type lectin domain family 2, member D (220132_s_at), score: -0.63 CNKSR2connector enhancer of kinase suppressor of Ras 2 (206731_at), score: -0.61 COL10A1collagen, type X, alpha 1 (217428_s_at), score: -0.61 CTSScathepsin S (202901_x_at), score: -0.62 CXCL10chemokine (C-X-C motif) ligand 10 (204533_at), score: -0.66 CYBBcytochrome b-245, beta polypeptide (203923_s_at), score: -0.59 CYCSP52cytochrome c, somatic pseudogene 52 (217206_at), score: -0.71 CYSLTR1cysteinyl leukotriene receptor 1 (216288_at), score: -0.61 DHRS9dehydrogenase/reductase (SDR family) member 9 (219799_s_at), score: -0.86 DNASE1L3deoxyribonuclease I-like 3 (205554_s_at), score: -0.66 DSC2desmocollin 2 (204751_x_at), score: -0.7 DTNBdystrobrevin, beta (215295_at), score: -0.84 DXS542X-linked retinopathy protein-like (222247_at), score: -0.64 EDAectodysplasin A (211130_x_at), score: -0.6 ENPP4ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function) (204160_s_at), score: -0.59 ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (202454_s_at), score: -0.6 ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) (214053_at), score: -0.7 FA2Hfatty acid 2-hydroxylase (219429_at), score: -0.6 GABRR1gamma-aminobutyric acid (GABA) receptor, rho 1 (206525_at), score: -0.6 GLRA1glycine receptor, alpha 1 (207972_at), score: -0.72 GNRHRgonadotropin-releasing hormone receptor (216341_s_at), score: -0.62 GP6glycoprotein VI (platelet) (220336_s_at), score: -0.63 GPR12G protein-coupled receptor 12 (214558_at), score: -0.77 GPR63G protein-coupled receptor 63 (220993_s_at), score: -0.74 HAVCR1hepatitis A virus cellular receptor 1 (207052_at), score: -0.64 HCG8HLA complex group 8 (215985_at), score: -0.62 HIST1H2ALhistone cluster 1, H2al (214554_at), score: -0.59 HIST1H4Ghistone cluster 1, H4g (208551_at), score: -0.6 HOXB6homeobox B6 (205366_s_at), score: -0.65 HPCAL4hippocalcin like 4 (219671_at), score: -0.63 ICA1islet cell autoantigen 1, 69kDa (211740_at), score: -0.81 KCNIP1Kv channel interacting protein 1 (221307_at), score: -0.72 KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (219564_at), score: -0.81 KIR3DX1killer cell immunoglobulin-like receptor, three domains, X1 (216428_x_at), score: -0.61 KLHL3kelch-like 3 (Drosophila) (221221_s_at), score: -0.59 KLHL4kelch-like 4 (Drosophila) (214591_at), score: -0.68 KRT2keratin 2 (207908_at), score: -0.72 KRT24keratin 24 (220267_at), score: -0.6 LAX1lymphocyte transmembrane adaptor 1 (207734_at), score: -0.64 LHX3LIM homeobox 3 (221670_s_at), score: -0.84 LILRP2leukocyte immunoglobulin-like receptor pseudogene 2 (214561_at), score: -0.61 LOC100130703similar to hCG2042168 (207596_at), score: -0.64 LOC100132247similar to Uncharacterized protein KIAA0220 (215002_at), score: -0.79 LOC100188945cell division cycle associated 4 pseudogene (215109_at), score: -0.57 LOC389906similar to Serine/threonine-protein kinase PRKX (Protein kinase PKX1) (59433_at), score: -0.66 LOC93432maltase-glucoamylase-like pseudogene (216666_at), score: -0.87 MAP3K9mitogen-activated protein kinase kinase kinase 9 (213927_at), score: -0.72 MAPK8IP1mitogen-activated protein kinase 8 interacting protein 1 (213013_at), score: -0.59 MBmyoglobin (204179_at), score: -0.73 MCF2L2MCF.2 cell line derived transforming sequence-like 2 (215112_x_at), score: -0.61 MFNGMFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (204153_s_at), score: -0.72 MGAT4Cmannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) (207447_s_at), score: -0.67 MGC5590hypothetical protein MGC5590 (220931_at), score: -0.69 MMRN2multimerin 2 (219091_s_at), score: -0.75 MOBPmyelin-associated oligodendrocyte basic protein (210193_at), score: -0.71 MSTP9macrophage stimulating, pseudogene 9 (213382_at), score: -0.65 MYBPC1myosin binding protein C, slow type (214087_s_at), score: -0.74 MYO1Amyosin IA (211916_s_at), score: -1 MYO5Cmyosin VC (218966_at), score: -0.83 N4BP3Nedd4 binding protein 3 (214775_at), score: -0.82 NCRNA00092non-protein coding RNA 92 (215861_at), score: -0.7 NMUneuromedin U (206023_at), score: -0.62 NRN1neuritin 1 (218625_at), score: -0.75 NTRK2neurotrophic tyrosine kinase, receptor, type 2 (207152_at), score: -0.81 NTRK3neurotrophic tyrosine kinase, receptor, type 3 (217033_x_at), score: -0.61 OR10C1olfactory receptor, family 10, subfamily C, member 1 (221339_at), score: -0.61 OR7E24olfactory receptor, family 7, subfamily E, member 24 (215463_at), score: -0.59 PCDH11Yprotocadherin 11 Y-linked (211227_s_at), score: -0.77 PDE3Aphosphodiesterase 3A, cGMP-inhibited (206388_at), score: -0.87 PDZRN4PDZ domain containing ring finger 4 (220595_at), score: -0.64 PECAM1platelet/endothelial cell adhesion molecule (208982_at), score: -0.72 PEG3paternally expressed 3 (209242_at), score: -0.69 PPIAL4Apeptidylprolyl isomerase A (cyclophilin A)-like 4A (217136_at), score: -0.68 PRLprolactin (205445_at), score: -0.79 PROL1proline rich, lacrimal 1 (208004_at), score: -0.72 PRSS7protease, serine, 7 (enterokinase) (217269_s_at), score: -0.89 PYHIN1pyrin and HIN domain family, member 1 (216748_at), score: -0.75 RAPGEF4Rap guanine nucleotide exchange factor (GEF) 4 (205651_x_at), score: -0.64 RLN1relaxin 1 (211753_s_at), score: -0.59 RNASE2ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) (206111_at), score: -0.71 RP11-35N6.1plasticity related gene 3 (219732_at), score: -0.93 RP4-692D3.1hypothetical protein LOC728621 (221171_at), score: -0.66 RPGRIP1retinitis pigmentosa GTPase regulator interacting protein 1 (206608_s_at), score: -0.59 RPH3Arabphilin 3A homolog (mouse) (205230_at), score: -0.58 S100A14S100 calcium binding protein A14 (218677_at), score: -0.67 SCARF1scavenger receptor class F, member 1 (206995_x_at), score: -0.73 SFTPBsurfactant protein B (214354_x_at), score: -0.64 SIGLEC6sialic acid binding Ig-like lectin 6 (210796_x_at), score: -0.62 SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (207185_at), score: -0.6 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (207095_at), score: -0.72 SLC12A3solute carrier family 12 (sodium/chloride transporters), member 3 (215274_at), score: -0.65 SLC15A1solute carrier family 15 (oligopeptide transporter), member 1 (211349_at), score: -0.65 SLC4A10solute carrier family 4, sodium bicarbonate transporter, member 10 (206830_at), score: -0.75 SLC6A14solute carrier family 6 (amino acid transporter), member 14 (219795_at), score: -0.76 STAP2signal transducing adaptor family member 2 (221610_s_at), score: -0.58 STXBP5Lsyntaxin binding protein 5-like (215518_at), score: -0.62 TAAR2trace amine associated receptor 2 (221394_at), score: -0.9 TACR1tachykinin receptor 1 (208048_at), score: -0.64 TAF4BTAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (216226_at), score: -0.61 TAS2R9taste receptor, type 2, member 9 (221461_at), score: -0.72 TGM4transglutaminase 4 (prostate) (217566_s_at), score: -0.6 TLR1toll-like receptor 1 (210176_at), score: -0.85 TMEM100transmembrane protein 100 (219230_at), score: -0.58 TMSB4Ythymosin beta 4, Y-linked (206769_at), score: -0.63 TSPY1testis specific protein, Y-linked 1 (216374_at), score: -0.78 VGFVGF nerve growth factor inducible (205586_x_at), score: -0.87 ZNF287zinc finger protein 287 (216710_x_at), score: -0.67
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-TABM-263-raw-cel-1515485911.cel | 14 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| ctrl a 08-03.CEL | 1 | 1 | DS-CC | hgu133a | none | DS-CC 1 |
| t21a 08-03.CEL | 4 | 1 | DS-CC | hgu133a | Down | DS-CC 4 |
| E-GEOD-3407-raw-cel-1437949557.cel | 1 | 4 | Cockayne | hgu133a | CS | eGFP |
| E-TABM-263-raw-cel-1515485651.cel | 1 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
