Under-expression is coded with green,
over-expression with red color.
DNA replication
The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.
cell cycle checkpoint
The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
M phase of mitotic cell cycle
A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.
mitotic cell cycle
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
M phase
A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.
nuclear division
A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
regulation of cell cycle
Any process that modulates the rate or extent of progression through the cell cycle.
cellular alcohol metabolic process
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
DNA metabolic process
The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
DNA-dependent DNA replication
The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
DNA replication initiation
The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
lipid metabolic process
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
steroid biosynthetic process
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
cholesterol biosynthetic process
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
isoprenoid metabolic process
The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
organelle organization
A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
microtubule-based process
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
cell cycle
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
mitosis
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
mitotic cell cycle checkpoint
A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
regulation of mitotic cell cycle
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
steroid metabolic process
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
cholesterol metabolic process
The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
cellular component organization
A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.
sterol metabolic process
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
sterol biosynthetic process
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
cell cycle process
A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
cell cycle phase
A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.
DNA integrity checkpoint
Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
cellular biopolymer metabolic process
The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
cellular biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biopolymer metabolic process
The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.
biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
organelle fission
The creation of two or more organelles by division of one organelle.
chromosome localization
Any process by which a chromosome is transported to, or maintained in, a specific location.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
localization
Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
cell division
The process resulting in the physical partitioning and separation of a cell into daughter cells.
establishment of chromosome localization
The directed movement of a chromosome to a specific location.
organelle localization
Any process by which an organelle is transported to, and/or maintained in, a specific location.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
establishment of organelle localization
The directed movement of an organelle to a specific location.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
all
This term is the most general term possible
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
cell cycle process
A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
regulation of cell cycle
Any process that modulates the rate or extent of progression through the cell cycle.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
establishment of chromosome localization
The directed movement of a chromosome to a specific location.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
cellular biopolymer metabolic process
The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
steroid metabolic process
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
lipid biosynthetic process
The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
regulation of mitotic cell cycle
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
establishment of organelle localization
The directed movement of an organelle to a specific location.
cellular biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
steroid biosynthetic process
The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.
sterol metabolic process
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
DNA metabolic process
The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
cellular biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
sterol biosynthetic process
The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
mitosis
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
mitotic cell cycle checkpoint
A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
M phase of mitotic cell cycle
A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.
establishment of chromosome localization
The directed movement of a chromosome to a specific location.
DNA replication
The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.
cholesterol biosynthetic process
The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
mitosis
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
DNA replication initiation
The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
condensed chromosome
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
chromosome, centromeric region
The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
kinetochore
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
condensed chromosome kinetochore
A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.
condensed chromosome, centromeric region
The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
spindle pole
Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
outer kinetochore of condensed chromosome
The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
nucleus
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
chromosome
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
spindle
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
microtubule
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule cytoskeleton
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
chromosomal part
Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
This term is the most general term possible
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
kinetochore
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
kinetochore
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
outer kinetochore of condensed chromosome
The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
spindle
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
outer kinetochore of condensed chromosome
The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
chromosomal part
Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
spindle pole
Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
kinetochore
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
condensed chromosome, centromeric region
The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
spindle
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
microtubule
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
condensed chromosome kinetochore
A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.
nucleotide binding
Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
motor activity
Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.
microtubule motor activity
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
nucleoside-triphosphatase activity
Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
ATP binding
Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
pyrophosphatase activity
Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
hydrolase activity
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
hydrolase activity, acting on acid anhydrides
Catalysis of the hydrolysis of any acid anhydride.
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.
purine nucleotide binding
Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate.
adenyl nucleotide binding
Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.
ribonucleotide binding
Interacting selectively with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
purine ribonucleotide binding
Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
adenyl ribonucleotide binding
Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
all
This term is the most general term possible
purine ribonucleotide binding
Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
adenyl ribonucleotide binding
Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 00100 | 9.727e-07 | 0.6328 | 9 | 23 | Biosynthesis of steroids |
| 04110 | 2.782e-04 | 2.696 | 13 | 98 | Cell cycle |
| 03030 | 1.738e-02 | 0.9079 | 6 | 33 | DNA replication |
ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (213353_at), score: 0.78 ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5 (219935_at), score: 0.74 ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (209612_s_at), score: 0.7 ANGPTL2angiopoietin-like 2 (213001_at), score: 0.79 ANK2ankyrin 2, neuronal (202920_at), score: 0.83 ATF3activating transcription factor 3 (202672_s_at), score: 0.72 ATP6V1G2ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 (214762_at), score: 0.74 AURKAaurora kinase A (208079_s_at), score: -0.65 AURKBaurora kinase B (209464_at), score: -0.69 BARD1BRCA1 associated RING domain 1 (205345_at), score: -0.66 BIRC5baculoviral IAP repeat-containing 5 (202095_s_at), score: -0.65 BRCA1breast cancer 1, early onset (204531_s_at), score: -0.64 BRIP1BRCA1 interacting protein C-terminal helicase 1 (221703_at), score: -0.69 BTG2BTG family, member 2 (201236_s_at), score: 0.71 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: -0.69 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (203755_at), score: -0.66 C13orf15chromosome 13 open reading frame 15 (218723_s_at), score: 0.74 C14orf1chromosome 14 open reading frame 1 (202562_s_at), score: 0.78 C17orf91chromosome 17 open reading frame 91 (214696_at), score: 0.73 C18orf24chromosome 18 open reading frame 24 (217640_x_at), score: -0.67 C1orf135chromosome 1 open reading frame 135 (220011_at), score: -0.68 C21orf45chromosome 21 open reading frame 45 (219004_s_at), score: -0.73 C4orf18chromosome 4 open reading frame 18 (219872_at), score: 0.8 CCDC15coiled-coil domain containing 15 (220466_at), score: -0.64 CCL11chemokine (C-C motif) ligand 11 (210133_at), score: 0.84 CCNA2cyclin A2 (203418_at), score: -0.66 CCNE2cyclin E2 (205034_at), score: -0.66 CCNFcyclin F (204826_at), score: -0.64 CDC20cell division cycle 20 homolog (S. cerevisiae) (202870_s_at), score: -0.66 CDC45LCDC45 cell division cycle 45-like (S. cerevisiae) (204126_s_at), score: -0.7 CDC6cell division cycle 6 homolog (S. cerevisiae) (203967_at), score: -0.67 CDC7cell division cycle 7 homolog (S. cerevisiae) (204510_at), score: -0.74 CDCA8cell division cycle associated 8 (221520_s_at), score: -0.68 CDK2cyclin-dependent kinase 2 (204252_at), score: -0.73 CDT1chromatin licensing and DNA replication factor 1 (209832_s_at), score: -0.65 CENPAcentromere protein A (204962_s_at), score: -0.65 CENPEcentromere protein E, 312kDa (205046_at), score: -0.68 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: -0.65 CENPIcentromere protein I (214804_at), score: -0.65 CENPMcentromere protein M (218741_at), score: -0.7 CENPQcentromere protein Q (219294_at), score: -0.64 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: -0.69 CKAP2cytoskeleton associated protein 2 (218252_at), score: -0.67 CLCN6chloride channel 6 (203950_s_at), score: 0.72 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: 0.84 COL21A1collagen, type XXI, alpha 1 (208096_s_at), score: 0.87 CORINcorin, serine peptidase (220356_at), score: 0.78 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: 0.93 CREB5cAMP responsive element binding protein 5 (205931_s_at), score: 0.7 CSTF2cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa (204459_at), score: -0.72 DAAM2dishevelled associated activator of morphogenesis 2 (212793_at), score: 0.72 DEPDC1DEP domain containing 1 (220295_x_at), score: -0.68 DEPDC6DEP domain containing 6 (218858_at), score: 0.7 DHCR77-dehydrocholesterol reductase (201790_s_at), score: 0.87 DHFRdihydrofolate reductase (202533_s_at), score: -0.64 DHRS12dehydrogenase/reductase (SDR family) member 12 (204800_s_at), score: 0.69 DHRS3dehydrogenase/reductase (SDR family) member 3 (202481_at), score: 0.71 DLEU2deleted in lymphocytic leukemia 2 (non-protein coding) (216870_x_at), score: -0.66 DLEU2Ldeleted in lymphocytic leukemia 2-like (215629_s_at), score: -0.71 DLGAP5discs, large (Drosophila) homolog-associated protein 5 (203764_at), score: -0.64 DPYSL2dihydropyrimidinase-like 2 (200762_at), score: 0.69 DRAMdamage-regulated autophagy modulator (218627_at), score: 0.71 DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (219512_at), score: -0.81 DTLdenticleless homolog (Drosophila) (218585_s_at), score: -0.64 ECM2extracellular matrix protein 2, female organ and adipocyte specific (206101_at), score: 0.83 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: 0.72 ENOX1ecto-NOX disulfide-thiol exchanger 1 (219501_at), score: 0.82 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (219650_at), score: -0.66 ERI2exoribonuclease 2 (213365_at), score: -0.71 EXOSC9exosome component 9 (205061_s_at), score: -0.7 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: -0.73 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: 0.99 FADS1fatty acid desaturase 1 (208962_s_at), score: 0.76 FADS2fatty acid desaturase 2 (202218_s_at), score: 0.69 FRYfurry homolog (Drosophila) (204072_s_at), score: 0.84 GABARAPL1GABA(A) receptor-associated protein like 1 (208868_s_at), score: 0.71 GALEUDP-galactose-4-epimerase (202528_at), score: -0.64 GALNAC4S-6STB cell RAG associated protein (203066_at), score: 0.82 GCH1GTP cyclohydrolase 1 (204224_s_at), score: 0.76 GDF15growth differentiation factor 15 (221577_x_at), score: 0.72 GDPD5glycerophosphodiester phosphodiesterase domain containing 5 (32502_at), score: 0.71 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: -0.64 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: -0.66 GINS3GINS complex subunit 3 (Psf3 homolog) (45633_at), score: -0.67 GINS4GINS complex subunit 4 (Sld5 homolog) (211767_at), score: -0.64 GPD2glycerol-3-phosphate dehydrogenase 2 (mitochondrial) (210007_s_at), score: -0.69 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: 0.7 GTSE1G-2 and S-phase expressed 1 (204318_s_at), score: -0.67 HELLShelicase, lymphoid-specific (220085_at), score: -0.67 HERC6hect domain and RLD 6 (219352_at), score: 0.75 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: 0.74 HJURPHolliday junction recognition protein (218726_at), score: -0.67 HMGCR3-hydroxy-3-methylglutaryl-Coenzyme A reductase (202540_s_at), score: 0.83 HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) (221750_at), score: 0.78 HSD17B2hydroxysteroid (17-beta) dehydrogenase 2 (204818_at), score: 0.7 HSD17B7hydroxysteroid (17-beta) dehydrogenase 7 (220081_x_at), score: 0.76 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: 0.69 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: 0.89 IFI44Linterferon-induced protein 44-like (204439_at), score: 0.72 IFIH1interferon induced with helicase C domain 1 (219209_at), score: 0.72 INSIG1insulin induced gene 1 (201627_s_at), score: 0.89 KCNB1potassium voltage-gated channel, Shab-related subfamily, member 1 (211006_s_at), score: 0.82 KCND3potassium voltage-gated channel, Shal-related subfamily, member 3 (213832_at), score: 0.93 KIF14kinesin family member 14 (206364_at), score: -0.71 KIF15kinesin family member 15 (219306_at), score: -0.66 KIF18Akinesin family member 18A (221258_s_at), score: -0.67 KIF18Bkinesin family member 18B (222039_at), score: -0.75 KIF2Ckinesin family member 2C (209408_at), score: -0.69 KIF4Akinesin family member 4A (218355_at), score: -0.71 KLF7Kruppel-like factor 7 (ubiquitous) (204334_at), score: 0.73 KNTC1kinetochore associated 1 (206316_s_at), score: -0.67 LDLRlow density lipoprotein receptor (202068_s_at), score: 0.75 LIG1ligase I, DNA, ATP-dependent (202726_at), score: -0.64 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.8 LMNB1lamin B1 (203276_at), score: -0.69 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: 0.81 LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (211019_s_at), score: 0.95 LZTFL1leucine zipper transcription factor-like 1 (218437_s_at), score: 0.78 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: -0.69 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: 0.75 MCM10minichromosome maintenance complex component 10 (220651_s_at), score: -0.76 MKI67antigen identified by monoclonal antibody Ki-67 (212022_s_at), score: -0.67 MVDmevalonate (diphospho) decarboxylase (203027_s_at), score: 0.83 MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (202086_at), score: 0.69 MX2myxovirus (influenza virus) resistance 2 (mouse) (204994_at), score: 0.75 NCAPHnon-SMC condensin I complex, subunit H (212949_at), score: -0.66 OIP5Opa interacting protein 5 (213599_at), score: -0.66 OLFML2Aolfactomedin-like 2A (213075_at), score: 0.76 OMDosteomodulin (205907_s_at), score: 0.73 ORAI3ORAI calcium release-activated calcium modulator 3 (221864_at), score: 0.79 ORC1Lorigin recognition complex, subunit 1-like (yeast) (205085_at), score: -0.65 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: -0.76 PAPPApregnancy-associated plasma protein A, pappalysin 1 (201981_at), score: 0.78 PDGFDplatelet derived growth factor D (219304_s_at), score: 0.72 PDGFRBplatelet-derived growth factor receptor, beta polypeptide (202273_at), score: 0.78 PIRpirin (iron-binding nuclear protein) (207469_s_at), score: 0.71 PLSCR4phospholipid scramblase 4 (218901_at), score: 0.73 PLXNC1plexin C1 (213241_at), score: 0.8 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: -0.72 POLE2polymerase (DNA directed), epsilon 2 (p59 subunit) (205909_at), score: -0.72 POLQpolymerase (DNA directed), theta (219510_at), score: -0.65 PPLperiplakin (203407_at), score: 1 PRELPproline/arginine-rich end leucine-rich repeat protein (204223_at), score: 0.72 PRIM1primase, DNA, polypeptide 1 (49kDa) (205053_at), score: -0.71 PRKG1protein kinase, cGMP-dependent, type I (207119_at), score: 1 PRPS2phosphoribosyl pyrophosphate synthetase 2 (203401_at), score: -0.74 PRSS12protease, serine, 12 (neurotrypsin, motopsin) (205515_at), score: 0.7 PSMC3IPPSMC3 interacting protein (213951_s_at), score: -0.7 PTGER4prostaglandin E receptor 4 (subtype EP4) (204897_at), score: 0.7 QPRTquinolinate phosphoribosyltransferase (204044_at), score: 0.81 RAB33ARAB33A, member RAS oncogene family (206039_at), score: 0.7 RAD54BRAD54 homolog B (S. cerevisiae) (219494_at), score: -0.76 RAD54LRAD54-like (S. cerevisiae) (204558_at), score: -0.64 RANGAP1Ran GTPase activating protein 1 (212125_at), score: -0.66 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: 0.77 RBL1retinoblastoma-like 1 (p107) (205296_at), score: -0.7 RELv-rel reticuloendotheliosis viral oncogene homolog (avian) (206036_s_at), score: 0.76 RFC3replication factor C (activator 1) 3, 38kDa (204127_at), score: -0.68 RNASEH2Aribonuclease H2, subunit A (203022_at), score: -0.64 ROR1receptor tyrosine kinase-like orphan receptor 1 (205805_s_at), score: 0.71 RRAGBRas-related GTP binding B (205540_s_at), score: 0.75 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: 0.92 SCDstearoyl-CoA desaturase (delta-9-desaturase) (200832_s_at), score: 0.82 SEMA3Dsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D (215324_at), score: 0.79 SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3 (202800_at), score: 0.72 SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14 (222088_s_at), score: 0.82 SLC2A3P1solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 (221751_at), score: 0.76 SPAG5sperm associated antigen 5 (203145_at), score: -0.7 SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) (209891_at), score: -0.65 SQLEsqualene epoxidase (213562_s_at), score: 0.99 SREBF1sterol regulatory element binding transcription factor 1 (202308_at), score: 0.75 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: 0.79 STILSCL/TAL1 interrupting locus (205339_at), score: -0.67 STK38Lserine/threonine kinase 38 like (212572_at), score: 0.77 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: 0.7 TACC3transforming, acidic coiled-coil containing protein 3 (218308_at), score: -0.66 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: 0.79 TBC1D12TBC1 domain family, member 12 (221858_at), score: 0.79 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: 0.74 TIMELESStimeless homolog (Drosophila) (203046_s_at), score: -0.65 TM7SF2transmembrane 7 superfamily member 2 (210130_s_at), score: 0.81 TMEM194Atransmembrane protein 194A (212621_at), score: -0.73 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: 0.71 TNFSF9tumor necrosis factor (ligand) superfamily, member 9 (206907_at), score: 0.76 TNXAtenascin XA pseudogene (213451_x_at), score: 0.71 TNXBtenascin XB (216333_x_at), score: 0.7 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (210052_s_at), score: -0.64 TRIP13thyroid hormone receptor interactor 13 (204033_at), score: -0.66 TSC22D3TSC22 domain family, member 3 (208763_s_at), score: 0.8 TTKTTK protein kinase (204822_at), score: -0.73 WDHD1WD repeat and HMG-box DNA binding protein 1 (216228_s_at), score: -0.64 WHSC1Wolf-Hirschhorn syndrome candidate 1 (209053_s_at), score: -0.64 WNT2wingless-type MMTV integration site family member 2 (205648_at), score: 0.81 WRAP53WD repeat containing, antisense to TP53 (44563_at), score: -0.65 XAF1XIAP associated factor 1 (206133_at), score: 0.75 YPEL5yippee-like 5 (Drosophila) (217783_s_at), score: 0.74
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-TABM-263-raw-cel-1515485851.cel | 11 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486271.cel | 32 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486291.cel | 33 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486231.cel | 30 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486331.cel | 35 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
