Under-expression is coded with green,
over-expression with red color.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
neurological system process
A organ system process carried out by any of the organs or tissues of neurological system.
sensory perception
The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
cognition
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
all
This term is the most general term possible
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
This term is the most general term possible
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
peptide receptor activity
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
G-protein coupled receptor activity
A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
neuropeptide receptor activity
Combining with a neuropeptide to initiate a change in cell activity.
peptide receptor activity, G-protein coupled
Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
neurotransmitter receptor activity
Combining with a neurotransmitter to initiate a change in cell activity.
neurotransmitter binding
Interacting selectively with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
peptide binding
Interacting selectively with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.
neuropeptide binding
Interacting selectively and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
This term is the most general term possible
neuropeptide receptor activity
Combining with a neuropeptide to initiate a change in cell activity.
peptide receptor activity
Combining with an extracellular or intracellular peptide to initiate a change in cell activity.
neurotransmitter receptor activity
Combining with a neurotransmitter to initiate a change in cell activity.
neuropeptide receptor activity
Combining with a neuropeptide to initiate a change in cell activity.
peptide receptor activity, G-protein coupled
Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
A1CFAPOBEC1 complementation factor (220951_s_at), score: -0.86 ABCG4ATP-binding cassette, sub-family G (WHITE), member 4 (207593_at), score: -0.75 ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif, 9 (220287_at), score: -0.73 AGMATagmatine ureohydrolase (agmatinase) (219792_at), score: -0.75 AIPL1aryl hydrocarbon receptor interacting protein-like 1 (219977_at), score: -0.77 APOMapolipoprotein M (205682_x_at), score: -0.75 BRS3bombesin-like receptor 3 (207369_at), score: -0.84 BTNL3butyrophilin-like 3 (217207_s_at), score: -0.86 C1orf61chromosome 1 open reading frame 61 (205103_at), score: -0.75 C2orf54chromosome 2 open reading frame 54 (220149_at), score: -0.72 C7orf28Achromosome 7 open reading frame 28A (201974_s_at), score: -0.76 C8orf17chromosome 8 open reading frame 17 (208266_at), score: -0.78 C8orf60chromosome 8 open reading frame 60 (220712_at), score: -0.79 CA4carbonic anhydrase IV (206209_s_at), score: -0.82 CASZ1castor zinc finger 1 (220015_at), score: -0.75 CATSPER2cation channel, sperm associated 2 (217588_at), score: -0.78 CCDC9coiled-coil domain containing 9 (206257_at), score: -0.74 CD53CD53 molecule (203416_at), score: -0.76 CEACAM5carcinoembryonic antigen-related cell adhesion molecule 5 (201884_at), score: -0.83 CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (211657_at), score: -0.79 CHST4carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 (220446_s_at), score: -0.77 CLDN10claudin 10 (205328_at), score: -0.8 CLEC4MC-type lectin domain family 4, member M (207995_s_at), score: -0.72 COL11A2collagen, type XI, alpha 2 (216993_s_at), score: -0.85 CYBBcytochrome b-245, beta polypeptide (203923_s_at), score: -0.88 CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 1 (1431_at), score: -0.71 DHRS9dehydrogenase/reductase (SDR family) member 9 (219799_s_at), score: -0.8 DNASE1L3deoxyribonuclease I-like 3 (205554_s_at), score: -0.81 DOHHdeoxyhypusine hydroxylase/monooxygenase (208141_s_at), score: -0.75 DRD5dopamine receptor D5 (208486_at), score: -0.85 EDAectodysplasin A (211130_x_at), score: -0.8 EDARectodysplasin A receptor (220048_at), score: -0.76 FAM38Bfamily with sequence similarity 38, member B (219602_s_at), score: -0.77 FGL1fibrinogen-like 1 (205305_at), score: -0.74 GBA3glucosidase, beta, acid 3 (cytosolic) (219954_s_at), score: -0.72 GLTSCR1glioma tumor suppressor candidate region gene 1 (219445_at), score: -0.73 GNG4guanine nucleotide binding protein (G protein), gamma 4 (205184_at), score: -0.8 GP1BAglycoprotein Ib (platelet), alpha polypeptide (207389_at), score: -0.73 GPATCH4G patch domain containing 4 (220596_at), score: -0.72 GPR12G protein-coupled receptor 12 (214558_at), score: -0.82 GPR157G protein-coupled receptor 157 (220901_at), score: -0.79 GPR32G protein-coupled receptor 32 (221469_at), score: -0.73 HAB1B1 for mucin (215778_x_at), score: -0.71 HOXD4homeobox D4 (205522_at), score: -0.78 HS3ST2heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (219697_at), score: -0.73 INE1inactivation escape 1 (non-protein coding) (207252_at), score: -0.74 KCNJ16potassium inwardly-rectifying channel, subfamily J, member 16 (219564_at), score: -0.71 KIR3DX1killer cell immunoglobulin-like receptor, three domains, X1 (216428_x_at), score: -0.78 KLF1Kruppel-like factor 1 (erythroid) (210504_at), score: -0.8 KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (205307_s_at), score: -0.71 LGALS14lectin, galactoside-binding, soluble, 14 (220158_at), score: -0.74 LHX3LIM homeobox 3 (221670_s_at), score: -0.85 LOC100188945cell division cycle associated 4 pseudogene (215109_at), score: -0.72 LOC643293FLJ44451 pseudogene (215057_at), score: -0.87 LONRF3LON peptidase N-terminal domain and ring finger 3 (220009_at), score: -0.82 MALmal, T-cell differentiation protein (204777_s_at), score: -0.73 MAPK8IP2mitogen-activated protein kinase 8 interacting protein 2 (205050_s_at), score: -0.74 MBmyoglobin (204179_at), score: -0.84 MFNGMFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (204153_s_at), score: -0.81 MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (203936_s_at), score: -0.74 MMRN2multimerin 2 (219091_s_at), score: -0.95 MOBPmyelin-associated oligodendrocyte basic protein (210193_at), score: -0.94 MSTP9macrophage stimulating, pseudogene 9 (213382_at), score: -0.76 MUC3Amucin 3A, cell surface associated (217117_x_at), score: -0.71 MYL4myosin, light chain 4, alkali; atrial, embryonic (210088_x_at), score: -0.77 MYO1Amyosin IA (211916_s_at), score: -0.82 N4BP3Nedd4 binding protein 3 (214775_at), score: -0.85 NPY2Rneuropeptide Y receptor Y2 (210730_s_at), score: -0.74 NRN1neuritin 1 (218625_at), score: -0.85 NTRK2neurotrophic tyrosine kinase, receptor, type 2 (207152_at), score: -0.72 NTRK3neurotrophic tyrosine kinase, receptor, type 3 (217033_x_at), score: -0.72 NYXnyctalopin (221684_s_at), score: -0.79 OR7E24olfactory receptor, family 7, subfamily E, member 24 (215463_at), score: -0.83 PAX4paired box 4 (207867_at), score: -0.77 PECAM1platelet/endothelial cell adhesion molecule (208982_at), score: -0.97 PEG3paternally expressed 3 (209242_at), score: -0.73 PGCprogastricsin (pepsinogen C) (205261_at), score: -0.76 PGK2phosphoglycerate kinase 2 (217009_at), score: -0.82 PIPOXpipecolic acid oxidase (221605_s_at), score: -0.76 POU4F1POU class 4 homeobox 1 (206940_s_at), score: -0.75 PPP4R4protein phosphatase 4, regulatory subunit 4 (220672_at), score: -0.76 PROL1proline rich, lacrimal 1 (208004_at), score: -0.71 PROX1prospero homeobox 1 (207401_at), score: -0.71 PRSS7protease, serine, 7 (enterokinase) (217269_s_at), score: -0.96 PYHIN1pyrin and HIN domain family, member 1 (216748_at), score: -0.79 RETret proto-oncogene (205879_x_at), score: -0.72 ROS1c-ros oncogene 1 , receptor tyrosine kinase (207569_at), score: -0.72 RP11-35N6.1plasticity related gene 3 (219732_at), score: -0.73 RPGRIP1retinitis pigmentosa GTPase regulator interacting protein 1 (206608_s_at), score: -0.85 RRHretinal pigment epithelium-derived rhodopsin homolog (208314_at), score: -0.76 S100A14S100 calcium binding protein A14 (218677_at), score: -0.81 SCN10Asodium channel, voltage-gated, type X, alpha subunit (208578_at), score: -0.88 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (207095_at), score: -0.77 SLC15A1solute carrier family 15 (oligopeptide transporter), member 1 (211349_at), score: -0.77 SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2 (208389_s_at), score: -0.79 SLC1A7solute carrier family 1 (glutamate transporter), member 7 (210923_at), score: -0.73 SLC26A10solute carrier family 26, member 10 (214951_at), score: -0.82 SLC4A10solute carrier family 4, sodium bicarbonate transporter, member 10 (206830_at), score: -0.72 SLCO1C1solute carrier organic anion transporter family, member 1C1 (220460_at), score: -0.77 SP140SP140 nuclear body protein (207777_s_at), score: -0.73 STXBP5Lsyntaxin binding protein 5-like (215518_at), score: -0.77 TACR1tachykinin receptor 1 (208048_at), score: -0.97 TBX21T-box 21 (220684_at), score: -0.85 TBX6T-box 6 (207684_at), score: -0.79 TMEM92transmembrane protein 92 (216791_at), score: -0.74 TMSB4Ythymosin beta 4, Y-linked (206769_at), score: -0.74 TULP2tubby like protein 2 (206733_at), score: -0.74 VGFVGF nerve growth factor inducible (205586_x_at), score: -1
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| ctrl a 08-03.CEL | 1 | 1 | DS-CC | hgu133a | none | DS-CC 1 |
| t21a 08-03.CEL | 4 | 1 | DS-CC | hgu133a | Down | DS-CC 4 |
| t21d 08-03.CEL | 7 | 1 | DS-CC | hgu133a | Down | DS-CC 7 |
| 2Twin.CEL | 2 | 2 | DS-twin | hgu133plus2 | none | DS-twin 2 |
| E-GEOD-3407-raw-cel-1437949557.cel | 1 | 4 | Cockayne | hgu133a | CS | eGFP |
| t21b 08-03.CEL | 5 | 1 | DS-CC | hgu133a | Down | DS-CC 5 |
| E-TABM-263-raw-cel-1515485711.cel | 4 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485651.cel | 1 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
