Under-expression is coded with green,
over-expression with red color.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
proteinaceous extracellular matrix
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endomembrane system
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
vesicle membrane
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
cytoplasmic vesicle membrane
The lipid bilayer surrounding a cytoplasmic vesicle.
extracellular matrix
A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as in plants).
organelle membrane
The lipid bilayer surrounding an organelle.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
vesicle
Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
membrane-bounded vesicle
Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
melanosome membrane
The lipid bilayer surrounding a melanosome.
melanosome
A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
extracellular matrix part
Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
chitosome
An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum.
pigment granule
A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes.
all
This term is the most general term possible
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
organelle membrane
The lipid bilayer surrounding an organelle.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
extracellular matrix part
Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
organelle membrane
The lipid bilayer surrounding an organelle.
vesicle membrane
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
vesicle membrane
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
cytoplasmic vesicle membrane
The lipid bilayer surrounding a cytoplasmic vesicle.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic vesicle membrane
The lipid bilayer surrounding a cytoplasmic vesicle.
melanosome membrane
The lipid bilayer surrounding a melanosome.
melanosome membrane
The lipid bilayer surrounding a melanosome.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
ATPase activity, coupled
Catalysis of the reaction: ATP + H2O = ADP + phosphate to directly drive some other reaction, for example ion transport across a membrane.
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
nucleoside-triphosphatase activity
Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
RNA-dependent ATPase activity
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of RNA; drives another reaction.
ATPase activity
Catalysis of the reaction: ATP + H2O = ADP + phosphate. May or may not be coupled to another reaction.
pyrophosphatase activity
Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.
hydrolase activity
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
hydrolase activity, acting on acid anhydrides
Catalysis of the hydrolysis of any acid anhydride.
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.
all
This term is the most general term possible
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 00983 | 2.385e-02 | 0.3511 | 4 | 29 | Drug metabolism - other enzymes |
| 00040 | 2.835e-02 | 0.1574 | 3 | 13 | Pentose and glucuronate interconversions |
A2Malpha-2-macroglobulin (217757_at), score: 0.56 ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 1 (209993_at), score: 1 ABCB4ATP-binding cassette, sub-family B (MDR/TAP), member 4 (207819_s_at), score: 0.68 ACIN1apoptotic chromatin condensation inducer 1 (201715_s_at), score: 0.54 AIM2absent in melanoma 2 (206513_at), score: 0.61 AKAP8LA kinase (PRKA) anchor protein 8-like (218064_s_at), score: 0.55 AKR1B10aldo-keto reductase family 1, member B10 (aldose reductase) (206561_s_at), score: 0.51 ANP32Aacidic (leucine-rich) nuclear phosphoprotein 32 family, member A (201043_s_at), score: 0.52 ARSJarylsulfatase family, member J (219973_at), score: -0.44 ATP6V1B2ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 (201089_at), score: 0.57 BAZ2Abromodomain adjacent to zinc finger domain, 2A (201353_s_at), score: 0.54 BHMT2betaine-homocysteine methyltransferase 2 (219902_at), score: 0.56 C10orf116chromosome 10 open reading frame 116 (203571_s_at), score: -0.47 C3orf64chromosome 3 open reading frame 64 (221935_s_at), score: -0.5 C4orf31chromosome 4 open reading frame 31 (219747_at), score: -0.45 C5orf30chromosome 5 open reading frame 30 (221823_at), score: -0.58 CA3carbonic anhydrase III, muscle specific (204865_at), score: 0.62 CCNL2cyclin L2 (221427_s_at), score: 0.53 CD248CD248 molecule, endosialin (219025_at), score: -0.43 CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1) (202284_s_at), score: -0.45 CDR2Lcerebellar degeneration-related protein 2-like (213230_at), score: -0.51 COL11A1collagen, type XI, alpha 1 (37892_at), score: -0.48 COPZ2coatomer protein complex, subunit zeta 2 (219561_at), score: -0.46 CRTAPcartilage associated protein (201380_at), score: -0.59 CRYABcrystallin, alpha B (209283_at), score: -0.5 DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 (208151_x_at), score: 0.68 DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked (201211_s_at), score: 0.54 DGKDdiacylglycerol kinase, delta 130kDa (208072_s_at), score: 0.55 DHX38DEAH (Asp-Glu-Ala-His) box polypeptide 38 (209178_at), score: 0.51 DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 9 (212105_s_at), score: 0.53 DIO2deiodinase, iodothyronine, type II (203699_s_at), score: 0.8 DUSP14dual specificity phosphatase 14 (203367_at), score: -0.48 EPHB2EPH receptor B2 (209589_s_at), score: 0.66 FAM169Afamily with sequence similarity 169, member A (213954_at), score: 0.64 FAT1FAT tumor suppressor homolog 1 (Drosophila) (201579_at), score: -0.61 FBN2fibrillin 2 (203184_at), score: -0.45 FKBP9FK506 binding protein 9, 63 kDa (212169_at), score: -0.62 GAGE4G antigen 4 (207086_x_at), score: 0.93 GAGE6G antigen 6 (208155_x_at), score: 0.89 GAS6growth arrest-specific 6 (202177_at), score: -0.44 GATA3GATA binding protein 3 (209604_s_at), score: 0.77 GHRgrowth hormone receptor (205498_at), score: -0.46 GLSglutaminase (203159_at), score: -0.5 GLTPglycolipid transfer protein (219267_at), score: -0.48 HAS2hyaluronan synthase 2 (206432_at), score: -0.48 HERC5hect domain and RLD 5 (219863_at), score: 0.7 HGSNATheparan-alpha-glucosaminide N-acetyltransferase (218017_s_at), score: -0.61 HIST1H4Chistone cluster 1, H4c (205967_at), score: -0.43 HIVEP2human immunodeficiency virus type I enhancer binding protein 2 (212642_s_at), score: -0.45 HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H) (213470_s_at), score: 0.51 HRASLSHRAS-like suppressor (219983_at), score: 0.53 HSPB7heat shock 27kDa protein family, member 7 (cardiovascular) (218934_s_at), score: -0.53 IGFBP3insulin-like growth factor binding protein 3 (212143_s_at), score: -0.43 IPO8importin 8 (205701_at), score: 0.51 IRS2insulin receptor substrate 2 (209185_s_at), score: -0.55 KCNS3potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 (205968_at), score: -0.43 KIAA0495KIAA0495 (213340_s_at), score: -0.48 LAMB3laminin, beta 3 (209270_at), score: 0.54 LDOC1leucine zipper, down-regulated in cancer 1 (204454_at), score: -0.47 LEF1lymphoid enhancer-binding factor 1 (221558_s_at), score: 0.52 LIPAlipase A, lysosomal acid, cholesterol esterase (201847_at), score: -0.44 LOC388796hypothetical LOC388796 (65588_at), score: 0.52 LOC728855hypothetical LOC728855 (222001_x_at), score: 0.58 LRRC2leucine rich repeat containing 2 (219949_at), score: -0.58 LTBP2latent transforming growth factor beta binding protein 2 (204682_at), score: -0.5 MAGOHmago-nashi homolog, proliferation-associated (Drosophila) (210092_at), score: 0.51 MAN2A1mannosidase, alpha, class 2A, member 1 (205105_at), score: -0.55 MARCH2membrane-associated ring finger (C3HC4) 2 (210075_at), score: -0.44 MARK1MAP/microtubule affinity-regulating kinase 1 (221047_s_at), score: 0.71 MED6mediator complex subunit 6 (207079_s_at), score: 0.52 MFAP5microfibrillar associated protein 5 (213764_s_at), score: -0.54 MITFmicrophthalmia-associated transcription factor (207233_s_at), score: 0.53 MOXD1monooxygenase, DBH-like 1 (209708_at), score: -0.46 MYO1Cmyosin IC (214656_x_at), score: -0.59 NCRNA00084non-protein coding RNA 84 (214657_s_at), score: 0.57 NEFLneurofilament, light polypeptide (221805_at), score: 0.7 NFASCneurofascin homolog (chicken) (213438_at), score: -0.45 NGDNneuroguidin, EIF4E binding protein (213794_s_at), score: 0.54 NMUneuromedin U (206023_at), score: 0.57 NOL12nucleolar protein 12 (219324_at), score: 0.52 NONOnon-POU domain containing, octamer-binding (208698_s_at), score: 0.62 NRGNneurogranin (protein kinase C substrate, RC3) (204081_at), score: 0.61 OASL2'-5'-oligoadenylate synthetase-like (210797_s_at), score: 0.97 PBX1pre-B-cell leukemia homeobox 1 (212148_at), score: -0.45 PCLOpiccolo (presynaptic cytomatrix protein) (213558_at), score: 0.53 PDE10Aphosphodiesterase 10A (205501_at), score: 0.56 PILRBpaired immunoglobin-like type 2 receptor beta (220954_s_at), score: 0.62 PPM2Cprotein phosphatase 2C, magnesium-dependent, catalytic subunit (218273_s_at), score: 0.53 PQBP1polyglutamine binding protein 1 (214527_s_at), score: 0.55 PTGER3prostaglandin E receptor 3 (subtype EP3) (213933_at), score: -0.49 QPCTglutaminyl-peptide cyclotransferase (205174_s_at), score: -0.5 RAB7L1RAB7, member RAS oncogene family-like 1 (218700_s_at), score: 0.52 RABGAP1LRAB GTPase activating protein 1-like (213982_s_at), score: -0.55 RECKreversion-inducing-cysteine-rich protein with kazal motifs (205407_at), score: -0.45 REEP1receptor accessory protein 1 (204364_s_at), score: 0.53 SAMD4Asterile alpha motif domain containing 4A (212845_at), score: -0.45 SERPINB7serpin peptidase inhibitor, clade B (ovalbumin), member 7 (206421_s_at), score: -0.45 SIDT2SID1 transmembrane family, member 2 (56256_at), score: -0.43 SLC16A1solute carrier family 16, member 1 (monocarboxylic acid transporter 1) (209900_s_at), score: -0.43 SLC30A1solute carrier family 30 (zinc transporter), member 1 (212907_at), score: -0.43 SLC4A4solute carrier family 4, sodium bicarbonate cotransporter, member 4 (203908_at), score: -0.47 SLC7A11solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 (217678_at), score: 0.54 SMEK1SMEK homolog 1, suppressor of mek1 (Dictyostelium) (220368_s_at), score: 0.6 SMG1SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) (210057_at), score: 0.54 SNCAsynuclein, alpha (non A4 component of amyloid precursor) (204466_s_at), score: 0.71 SPARCsecreted protein, acidic, cysteine-rich (osteonectin) (212667_at), score: -0.45 SSR3signal sequence receptor, gamma (translocon-associated protein gamma) (217790_s_at), score: -0.5 SYTL2synaptotagmin-like 2 (220613_s_at), score: 0.51 TBC1D8TBC1 domain family, member 8 (with GRAM domain) (204526_s_at), score: 0.53 TCEAL2transcription elongation factor A (SII)-like 2 (211276_at), score: 0.77 TEKTEK tyrosine kinase, endothelial (206702_at), score: -0.53 TIMP2TIMP metallopeptidase inhibitor 2 (203167_at), score: -0.55 TMEM204transmembrane protein 204 (219315_s_at), score: -0.42 TMEM47transmembrane protein 47 (209656_s_at), score: -0.55 TMOD1tropomodulin 1 (203661_s_at), score: 0.6 TNS1tensin 1 (221748_s_at), score: -0.53 TOB1transducer of ERBB2, 1 (202704_at), score: -0.5 TSPAN13tetraspanin 13 (217979_at), score: -0.51 TSPYL5TSPY-like 5 (213122_at), score: -0.48 TYRP1tyrosinase-related protein 1 (205694_at), score: 0.54 UAP1UDP-N-acteylglucosamine pyrophosphorylase 1 (209340_at), score: -0.51 UBL3ubiquitin-like 3 (201535_at), score: -0.57 UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (201387_s_at), score: -0.42 UGT1A1UDP glucuronosyltransferase 1 family, polypeptide A1 (207126_x_at), score: 0.87 UGT1A6UDP glucuronosyltransferase 1 family, polypeptide A6 (206094_x_at), score: 0.88 UGT1A9UDP glucuronosyltransferase 1 family, polypeptide A9 (204532_x_at), score: 0.86 USP18ubiquitin specific peptidase 18 (219211_at), score: 0.51 VWA5Avon Willebrand factor A domain containing 5A (210102_at), score: 0.55 WDR48WD repeat domain 48 (222157_s_at), score: 0.53 WT1Wilms tumor 1 (206067_s_at), score: 0.68
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-GEOD-4219-raw-cel-1311956178.cel | 6 | 7 | Sph-mono | hgu133plus2 | none | Sph-mon 1 |
| E-GEOD-4219-raw-cel-1311956358.cel | 10 | 7 | Sph-mono | hgu133plus2 | none | Sph-mon 1 |
| E-GEOD-4219-raw-cel-1311956824.cel | 24 | 7 | Sph-mono | hgu133plus2 | none | Sph-mon 1 |
| E-GEOD-3407-raw-cel-1437949854.cel | 7 | 4 | Cockayne | hgu133a | CS | eGFP |
| E-GEOD-3407-raw-cel-1437949938.cel | 8 | 4 | Cockayne | hgu133a | none | CSB |
| E-GEOD-3407-raw-cel-1437949579.cel | 2 | 4 | Cockayne | hgu133a | none | CSB |
| E-GEOD-3407-raw-cel-1437949721.cel | 5 | 4 | Cockayne | hgu133a | CS | CSB |
| E-GEOD-3407-raw-cel-1437949750.cel | 6 | 4 | Cockayne | hgu133a | CS | CSB |
