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Module #791, TG: 2.6, TC: 1, 85 probes, 85 Entrez genes, 35 conditions
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The image plot shows the color-coded level of gene expression, for the
genes and conditions in a given transcription module. The genes are on
the horizontal, the conditions on the vertical axis.
The genes are ordered according to their ISA gene scores, similarly
the conditions are ordered according to their condition scores. The
score of a gene means the «degree of inclusion» in
the module: a high score gene is essential in the module.
Condition scores can also be negative, that means that the genes of
the module are all down-regulated in the condition. Here the absolute
value of the score gives the «degree of inclusion».
The plots above and beside the expression matrix show the gene scores
and condition scores, respectively.
Note that the plot is interactive, you can see the name of the gene
and condition under the mouse cursor.
The expression matrix was normalized to have mean zero and standard
deviation one for every gene separately across all conditions
(i.e. not just for the conditions in the module).
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Under-expression is coded with green,
over-expression with red color.
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The GO tree — Biological processes
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This is one of three sections showing Gene Ontology enrichment of the
current module: in this case for biological processes.
The graph shows the hierarchy of the GO categories, their enrichment
for the current module is color coded, and the blue number beside the
category is the minus log ten p-value of the enrichment. (Calculated
using the standard hypergeometric test.) The color of the arrows code
«is a» (cyan) and «part of» relationships.
The tree was built the following way. First all GO terms with more
significant enrichment p-value than 0.05 were collected. Then all
paths from these terms to the root node of the GO tree were included
too. If a GO term is included more than once in the tree, then the
green numbers show 1) the id of the node, this makes it easier to find
other appereances of the term, and 2) the number of appearences.
Note that the same GO category might show up on the graph many
times. This is because the GO was «straightened» for this
graph, i.e. if there are more paths from a GO term to the root node of
the tree, all of them are included. The green numbers
Move the mouse cursor over the terms to get their definition. Clicking
on them takes you to the corresponding Gene Ontology web page.
If you cannot see a graph here at all, that means that there were no
significantly enriched GO categories, at the 0.05 level.
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The GO tree — Cellular Components
HELP
This is one of three sections showing Gene Ontology enrichment of the
current module: in this case for cellular components.
The graph shows the hierarchy of the GO categories, their enrichment
for the current module is color coded, and the blue number beside the
category is the minus log ten p-value of the enrichment. (Calculated
using the standard hypergeometric test.) The color of the arrows code
«is a» (cyan) and «part of» relationships.
The tree was built the following way. First all GO terms with more
significant enrichment p-value than 0.05 were collected. Then all
paths from these terms to the root node of the GO tree were included
too. If a GO term is included more than once in the tree, then the
green numbers show 1) the id of the node, this makes it easier to find
other appereances of the term, and 2) the number of appearences.
Note that the same GO category might show up on the graph many
times. This is because the GO was «straightened» for this
graph, i.e. if there are more paths from a GO term to the root node of
the tree, all of them are included. The green numbers
Move the mouse cursor over the terms to get their definition. Clicking
on them takes you to the corresponding Gene Ontology web page.
If you cannot see a graph here at all, that means that there were no
significantly enriched GO categories, at the 0.05 level.
— Click on the Help button again to close this help window.
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The GO tree — Molecular Function
HELP
This is one of three sections showing Gene Ontology enrichment of the
current module: in this case for molecular function.
The graph shows the hierarchy of the GO categories, their enrichment
for the current module is color coded, and the blue number beside the
category is the minus log ten p-value of the enrichment. (Calculated
using the standard hypergeometric test.) The color of the arrows code
«is a» (cyan) and «part of» relationships.
The tree was built the following way. First all GO terms with more
significant enrichment p-value than 0.05 were collected. Then all
paths from these terms to the root node of the GO tree were included
too. If a GO term is included more than once in the tree, then the
green numbers show 1) the id of the node, this makes it easier to find
other appereances of the term, and 2) the number of appearences.
Note that the same GO category might show up on the graph many
times. This is because the GO was «straightened» for this
graph, i.e. if there are more paths from a GO term to the root node of
the tree, all of them are included. The green numbers
Move the mouse cursor over the terms to get their definition. Clicking
on them takes you to the corresponding Gene Ontology web page.
If you cannot see a graph here at all, that means that there were no
significantly enriched GO categories, at the 0.05 level.
— Click on the Help button again to close this help window.
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GO BP test for over-representation
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List of all enriched GO categories (biological processes), at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module annotated with the given GO term, just by chance.
- Count
is the number of genes in the module annotated with the given GO
term.
- Size is the total number of genes (in our universe)
annotated with the GO term.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
GO category.
Clicking on the GO identifiers takes you to the Gene Ontology web
pages.
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| Id | Pvalue | ExpCount | Count | Size | Term |
| GO:0043112 | 3.144e-02 | 0.1608 | 3
AGRN, ECE1, FURIN | 17 | receptor metabolic process |
| GO:0035050 | 3.239e-02 | 0.03783 | 2
FOXC2, HHEX | 4 | embryonic heart tube development |
| GO:0010553 | 4.541e-02 | 0.04729 | 2
HHEX, NFKB1 | 5 | negative regulation of specific transcription from RNA polymerase II promoter |
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GO CC test for over-representation
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List of all enriched GO categories (cellular components), at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module annotated with the given GO term, just by chance.
- Count
is the number of genes in the module annotated with the given GO
term.
- Size is the total number of genes (in our universe)
annotated with the GO term.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
GO category.
Clicking on the GO identifiers takes you to the Gene Ontology web
pages.
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GO MF test for over-representation
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List of all enriched GO categories (molecular function), at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module annotated with the given GO term, just by chance.
- Count
is the number of genes in the module annotated with the given GO
term.
- Size is the total number of genes (in our universe)
annotated with the GO term.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
GO category.
Clicking on the GO identifiers takes you to the Gene Ontology web
pages.
— Click on the Help button again to close this help window.
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KEGG Pathway test for over-representation
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List of all enriched KEGG pathways, at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module annotated with the given KEGG pathway, just by chance.
- Count
is the number of genes in the module annotated with the given KEGG
pathway.
- Size is the total number of genes (in our universe)
annotated with the KEGG pathway.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
KEGG pathway.
Clicking on the KEGG identifiers takes you to the KEGG web site.
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miRNA test for over-representation
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List of all enriched miRNA families, at the 0.05
p-value level.
The columns:
- ExpCount is the expected count of genes in the
module regulated by the given miRNA family, just by chance.
- Count
is the number of genes in the module regulated by the given miRNA
family.
- Size is the total number of genes (in our universe)
regulated with the given miRNA family.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
miRNA family.
The miRNA regulation data was taken from the TargetScan database.
(Only the conserved sites were used for the current analysis.)
Clicking on the miRNA names takes you to the TargetScan web site.
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Chromosome test for over-representation
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List of all enriched Chromosomes, at the 0.05
p-value level.
The columns:
- ExpCount is the expected number of genes in the
module on the given chromosome, just by chance.
- Count
is the number of genes in the module on the given chromosome.
- Size is the total number of genes (in our universe)
on the given chromosome.
Clicking on Count shows the genes that drive the
enrichment. You can also click on the individual numbers in
the Count column, to show the driving genes for that individual
chromosome.
— Click on the Help button again to close this help window.
HELP
A list of all genes in the current module, in alphabetical order. The
size of the text corresponds to the gene scores.
Note that some gene symbols may show up more than once, if many
probes match the same Entrez gene.
Genes with no Entrez mapping are given separately, with their
Affymetrics probe ID.
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Entrez genes
ABCD1ATP-binding cassette, sub-family D (ALD), member 1 (205142_x_at), score: -0.65
AGRNagrin (217419_x_at), score: -0.64
ARSAarylsulfatase A (204443_at), score: -0.71
BAT2HLA-B associated transcript 2 (212081_x_at), score: -0.65
BAT2LHLA-B associated transcript 2-like (212068_s_at), score: -0.56
C16orf45chromosome 16 open reading frame 45 (212736_at), score: -0.56
CALCOCO1calcium binding and coiled-coil domain 1 (209002_s_at), score: -0.64
CLIP3CAP-GLY domain containing linker protein 3 (212358_at), score: -0.67
COL18A1collagen, type XVIII, alpha 1 (209081_s_at), score: -0.68
CRTC3CREB regulated transcription coactivator 3 (218648_at), score: -0.62
DGCR2DiGeorge syndrome critical region gene 2 (214198_s_at), score: 0.88
DMPKdystrophia myotonica-protein kinase (37996_s_at), score: -0.64
DNAJC4DnaJ (Hsp40) homolog, subfamily C, member 4 (206782_s_at), score: -0.55
DOPEY1dopey family member 1 (40612_at), score: 0.86
DUS2Ldihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae) (47105_at), score: 0.88
DUSP3dual specificity phosphatase 3 (201537_s_at), score: -0.57
ECE1endothelin converting enzyme 1 (201750_s_at), score: -0.55
ECM1extracellular matrix protein 1 (209365_s_at), score: -0.72
FAM102Afamily with sequence similarity 102, member A (212400_at), score: -0.59
FHOD1formin homology 2 domain containing 1 (218530_at), score: -0.8
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1) (214520_at), score: -0.64
FOXF1forkhead box F1 (205935_at), score: -0.56
FOXK2forkhead box K2 (203064_s_at), score: -0.67
FURINfurin (paired basic amino acid cleaving enzyme) (201945_at), score: -0.57
HBS1LHBS1-like (S. cerevisiae) (209314_s_at), score: 0.86
HHEXhematopoietically expressed homeobox (215933_s_at), score: -0.56
HLA-Emajor histocompatibility complex, class I, E (200904_at), score: -0.77
HSF1heat shock transcription factor 1 (202344_at), score: -0.6
IDUAiduronidase, alpha-L- (205059_s_at), score: -0.76
INPP1inositol polyphosphate-1-phosphatase (202794_at), score: -0.6
JUNDjun D proto-oncogene (203751_x_at), score: -0.72
JUPjunction plakoglobin (201015_s_at), score: -0.63
KIAA1305KIAA1305 (220911_s_at), score: -0.62
KLHL26kelch-like 26 (Drosophila) (219354_at), score: -0.63
LEPREL2leprecan-like 2 (204854_at), score: -0.56
LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: -0.55
LOC440434hypothetical protein FLJ11822 (215090_x_at), score: -0.61
MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: -0.69
MAP1Smicrotubule-associated protein 1S (218522_s_at), score: -0.84
NACAP1nascent-polypeptide-associated complex alpha polypeptide pseudogene 1 (211445_x_at), score: 0.87
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: -0.71
NID1nidogen 1 (202008_s_at), score: -0.56
NINJ1ninjurin 1 (203045_at), score: -0.76
PCDHG@protocadherin gamma cluster (215836_s_at), score: -0.7
PCDHGA11protocadherin gamma subfamily A, 11 (211876_x_at), score: -0.68
PCDHGA3protocadherin gamma subfamily A, 3 (216352_x_at), score: -0.61
PDE5Aphosphodiesterase 5A, cGMP-specific (206757_at), score: -0.57
PHF7PHD finger protein 7 (215622_x_at), score: 0.89
PIP5K1Cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma (212518_at), score: -0.76
PLAUplasminogen activator, urokinase (211668_s_at), score: -0.58
PORP450 (cytochrome) oxidoreductase (208928_at), score: -0.61
PRKCDprotein kinase C, delta (202545_at), score: -0.63
PTPROprotein tyrosine phosphatase, receptor type, O (211600_at), score: -0.65
PXNpaxillin (211823_s_at), score: -0.68
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 1 (209941_at), score: -0.58
RNF130ring finger protein 130 (217865_at), score: -0.63
RPS17P5ribosomal protein S17 pseudogene 5 (216348_at), score: 1
SAV1salvador homolog 1 (Drosophila) (218276_s_at), score: -0.62
SCAMP4secretory carrier membrane protein 4 (213244_at), score: -0.71
SGSHN-sulfoglucosamine sulfohydrolase (35626_at), score: -0.56
SH3GLB2SH3-domain GRB2-like endophilin B2 (218813_s_at), score: -0.59
SHBSrc homology 2 domain containing adaptor protein B (204657_s_at), score: -0.62
SIN3BSIN3 homolog B, transcription regulator (yeast) (209352_s_at), score: -0.56
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (209830_s_at), score: -0.62
SOLHsmall optic lobes homolog (Drosophila) (204275_at), score: -0.66
SPATA20spermatogenesis associated 20 (218164_at), score: -0.65
SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: -0.56
SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: -0.67
TAPBPTAP binding protein (tapasin) (208829_at), score: -0.67
TBC1D2BTBC1 domain family, member 2B (212796_s_at), score: -0.59
TERF2telomeric repeat binding factor 2 (203611_at), score: -0.56
TNFAIP2tumor necrosis factor, alpha-induced protein 2 (202510_s_at), score: -0.65
TP53I11tumor protein p53 inducible protein 11 (214667_s_at), score: -0.63
TPP1tripeptidyl peptidase I (200742_s_at), score: -0.6
TSC2tuberous sclerosis 2 (215735_s_at), score: -0.57
TSKUtsukushin (218245_at), score: -0.63
TUBA4Btubulin, alpha 4b (pseudogene) (207490_at), score: 0.97
UBTD1ubiquitin domain containing 1 (219172_at), score: -0.59
USF2upstream transcription factor 2, c-fos interacting (202152_x_at), score: -0.63
VEGFBvascular endothelial growth factor B (203683_s_at), score: -0.85
VPS37Bvacuolar protein sorting 37 homolog B (S. cerevisiae) (221704_s_at), score: -0.7
WBP2WW domain binding protein 2 (209117_at), score: -0.6
WDR42AWD repeat domain 42A (202249_s_at), score: -0.59
WDR6WD repeat domain 6 (217734_s_at), score: -0.6
ZNF282zinc finger protein 282 (212892_at), score: -0.59
Non-Entrez genes
Unknown, score:
HELP
Conditions in the module, given in the same order as on the expression
plot above. Red color means over-expression, green under-expression in
the given condition.
The barplot below shows the condition (sample) scores. A separate bar
is shown for each sample, its height is the corresponding score of the
sample in the module. The red and green numbers on the bars are the
sample scores expressed in percents, i.e. 100% is 1.0.
The red and green lines show the module thresholds, samples above
the red line and below the green line are included in the module.
The different experiments that were part of the study, are separated
by dashed vertical lines.
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| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
| 46A.CEL | 1 | 3 | DS-mosaic | hgu133plus2 | none | DS-mosaic 1 |
| E-TABM-263-raw-cel-1515486211.cel | 29 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486411.cel | 39 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485691.cel | 3 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485991.cel | 18 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485871.cel | 12 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486071.cel | 22 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485971.cel | 17 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485711.cel | 4 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486291.cel | 33 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485831.cel | 10 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| 46C.CEL | 3 | 3 | DS-mosaic | hgu133plus2 | none | DS-mosaic 3 |
| E-TABM-263-raw-cel-1515486171.cel | 27 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-GEOD-3860-raw-cel-1561690376.cel | 13 | 5 | HGPS | hgu133a | HGPS | AG11513 |
| 47B.CEL | 4 | 3 | DS-mosaic | hgu133plus2 | Down mosaic | DS-mosaic 4 |
| E-TABM-263-raw-cel-1515485791.cel | 8 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-GEOD-3860-raw-cel-1561690272.cel | 7 | 5 | HGPS | hgu133a | HGPS | AG11498 |
| t21d 08-03.CEL | 7 | 1 | DS-CC | hgu133a | Down | DS-CC 7 |
| E-TABM-263-raw-cel-1515486151.cel | 26 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| 4Twin.CEL | 4 | 2 | DS-twin | hgu133plus2 | none | DS-twin 4 |
| E-TABM-263-raw-cel-1515485671.cel | 2 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486011.cel | 19 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| t21c 08-03.CEL | 6 | 1 | DS-CC | hgu133a | Down | DS-CC 6 |
| E-TABM-263-raw-cel-1515485811.cel | 9 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486091.cel | 23 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485891.cel | 13 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486431.cel | 40 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| 2Twin.CEL | 2 | 2 | DS-twin | hgu133plus2 | none | DS-twin 2 |
| 6Twin.CEL | 6 | 2 | DS-twin | hgu133plus2 | none | DS-twin 6 |
| E-TABM-263-raw-cel-1515486371.cel | 37 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| 1Twin.CEL | 1 | 2 | DS-twin | hgu133plus2 | Down | DS-twin 1 |
| E-GEOD-3407-raw-cel-1437949557.cel | 1 | 4 | Cockayne | hgu133a | CS | eGFP |
| 5CTwin.CEL | 5 | 2 | DS-twin | hgu133plus2 | Down | DS-twin 5 |
| E-TABM-263-raw-cel-1515485771.cel | 7 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515485751.cel | 6 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
© 2008-2010 Computational Biology Group, Department of Medical Genetics,
University of Lausanne, Switzerland
