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DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

chromosome segregation

The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.

chromosome organization

A process that is carried out at the cellular level that results in the formation, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

cell cycle checkpoint

The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.

S phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

mitotic cell cycle

Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

M phase

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.

nuclear division

A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.

double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

recombinational repair

The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

cellular alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

DNA-dependent DNA replication

The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

DNA strand elongation during DNA replication

The process by which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

nucleotide-excision repair

In nucleotide excision repair a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts).

nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.

double-strand break repair

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

DNA recombination

Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.

DNA packaging

Any process by which DNA and associated proteins are formed into a compact, orderly structure.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

response to DNA damage stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

organelle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

microtubule-based process

Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

cell cycle

The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

intracellular signaling cascade

A series of reactions within the cell that occur as a result of a single trigger reaction or compound.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cellular component organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

second-messenger-mediated signaling

A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.

phosphoinositide-mediated signaling

A series of molecular signals in which a cell uses a phosphoinositide to convert an extracellular signal into a response.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cell cycle phase

A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.

DNA strand elongation

The DNA metabolic process by which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand.

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

cytoskeleton-dependent intracellular transport

The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

DNA integrity checkpoint

Any cell cycle checkpoint that delays or arrests cell cycle progression in response to changes in DNA structure.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

intracellular transport

The directed movement of substances within a cell.

organelle fission

The creation of two or more organelles by division of one organelle.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cell division

The process resulting in the physical partitioning and separation of a cell into daughter cells.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cellular response to stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

cellular localization

Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

cell cycle process

A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell cycle

Any process that modulates the rate or extent of progression through the cell cycle.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

establishment of localization in cell

The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.

cellular response to stress

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

intracellular transport

The directed movement of substances within a cell.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

negative regulation of cellular metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

negative regulation of macromolecule metabolic process

Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.

cellular macromolecule biosynthetic process

The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

regulation of mitotic cell cycle

Any process that modulates the rate or extent of progress through the mitotic cell cycle.

regulation of cell cycle process

Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.

cellular response to DNA damage stimulus

A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

DNA metabolic process

The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.

cellular biopolymer biosynthetic process

The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

regulation of DNA metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.

negative regulation of DNA metabolic process

Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

mitotic cell cycle checkpoint

A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.

mitotic chromosome condensation

The cell cycle process whereby chromatin structure is compacted prior to mitosis in eukaryotic cells.

sister chromatid segregation

The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.

chromosome condensation

The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

microtubule cytoskeleton organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.

M phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.

spindle organization

A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.

mitotic sister chromatid segregation

The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.

regulation of mitosis

Any process that modulates the frequency, rate or extent of mitosis.

S phase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place.

S phase

A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.

interphase of mitotic cell cycle

A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.

DNA repair

The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.

microtubule-based movement

Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins.

DNA replication

The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

DNA synthesis during DNA repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

recombinational repair

The repair of damaged DNA that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.

mitosis

A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.

DNA replication initiation

The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.

DNA strand elongation during DNA replication

The process by which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.

nucleotide-excision repair, DNA gap filling

Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes.

double-strand break repair via homologous recombination

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

condensed chromosome

A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosome, centromeric region

The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

nucleus

A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

replication fork

The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

chromosome

A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule associated complex

Any multimeric complex connected to a microtubule.

microtubule cytoskeleton

The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

protein-DNA complex

A macromolecular complex containing both protein and DNA molecules.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

all

This term is the most general term possible

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular organelle lumen

An organelle lumen that is part of an intracellular organelle.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear lumen

The volume enclosed by the nuclear inner membrane.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule associated complex

Any multimeric complex connected to a microtubule.

nucleoplasm

That part of the nuclear content other than the chromosomes or the nucleolus.

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

outer kinetochore of condensed chromosome

The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.

nuclear part

Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.

nuclear chromosome

A chromosome found in the nucleus of a eukaryotic cell.

chromosomal part

Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.

spindle pole

Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

kinetochore

A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

replisome

A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

alpha DNA polymerase:primase complex

A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.

nuclear replication fork

The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nuclear chromosome part

Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.

condensed chromosome, centromeric region

The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.

condensin complex

A multisubunit protein complex that plays a central role in chromosome condensation.

spindle

The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.

microtubule

Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.

microtubule associated complex

Any multimeric complex connected to a microtubule.

condensed chromosome kinetochore

A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.

nuclear replisome

A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.

nucleotide binding

Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

chromatin binding

Interacting selectively with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase.

motor activity

Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.

microtubule motor activity

Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

DNA-directed DNA polymerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer.

nucleoside-triphosphatase activity

Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

ATP binding

Interacting selectively with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

pyrophosphatase activity

Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments.

transferase activity

Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

transferase activity, transferring phosphorus-containing groups

Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).

nucleotidyltransferase activity

Catalysis of the transfer of a nucleotidyl group to a reactant.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on acid anhydrides

Catalysis of the hydrolysis of any acid anhydride.

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.

purine nucleotide binding

Interacting selectively with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate.

adenyl nucleotide binding

Interacting selectively with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.

ribonucleotide binding

Interacting selectively with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

DNA polymerase activity

Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and primer.

all

This term is the most general term possible

purine ribonucleotide binding

Interacting selectively with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

adenyl ribonucleotide binding

Interacting selectively with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022403	1.487e-41	10.97	76 ASPM, AURKA, AURKB, BIRC5, BLM, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CENPE, CENPF, CEP55, CHEK1, CIT, DDX11, DLGAP5, DSN1, ERCC6L, EXO1, GTSE1, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, POLA1, POLD1, POLE, PSMC3IP, PTTG1, RAD54B, RAD54L, SMC2, SPAG5, SPC25, STMN1, TACC3, TIMELESS, TPX2, TTK, UBE2C, ZWINT	287	cell cycle phase
GO:0000279	7.188e-39	8.833	67 ASPM, AURKA, AURKB, BIRC5, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CHEK1, CIT, DDX11, DLGAP5, DSN1, ERCC6L, EXO1, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PSMC3IP, PTTG1, RAD54B, RAD54L, SMC2, SPAG5, SPC25, STMN1, TACC3, TIMELESS, TPX2, TTK, UBE2C, ZWINT	231	M phase
GO:0000280	5.904e-37	6.654	58 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CIT, DDX11, DLGAP5, DSN1, ERCC6L, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SPAG5, SPC25, TIMELESS, TPX2, UBE2C, ZWINT	174	nuclear division
GO:0007067	5.904e-37	6.654	58 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CIT, DDX11, DLGAP5, DSN1, ERCC6L, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SPAG5, SPC25, TIMELESS, TPX2, UBE2C, ZWINT	174	mitosis
GO:0000087	1.713e-36	6.769	58 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CIT, DDX11, DLGAP5, DSN1, ERCC6L, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SPAG5, SPC25, TIMELESS, TPX2, UBE2C, ZWINT	177	M phase of mitotic cell cycle
GO:0048285	4.809e-36	6.883	58 ASPM, AURKA, AURKB, BIRC5, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CENPE, CENPF, CEP55, CIT, DDX11, DLGAP5, DSN1, ERCC6L, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PTTG1, SMC2, SPAG5, SPC25, TIMELESS, TPX2, UBE2C, ZWINT	180	organelle fission
GO:0007049	7.122e-35	24.93	101 ASPM, AURKA, AURKB, BARD1, BIRC5, BLM, BMP2, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CENPE, CENPF, CEP55, CHAF1A, CHAF1B, CHEK1, CIT, CKAP2, DDX11, DLGAP5, DSCC1, DSN1, E2F8, ERCC6L, EXO1, FANCG, FANCI, GMNN, GTSE1, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, LIG1, MAD2L1, MCM2, MCM3, MCM7, MKI67, MSH2, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, POLA1, POLD1, POLE, PSMC3IP, PSRC1, PTTG1, RAD54B, RAD54L, RBL1, SMC2, SPAG5, SPC25, STMN1, SUV39H1, TACC3, TIMELESS, TP53BP2, TPX2, TTK, TXNIP, UBE2C, ZWINT	652	cell cycle
GO:0022402	5.101e-34	15.1	79 ASPM, AURKA, AURKB, BARD1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CENPE, CENPF, CEP55, CHEK1, CIT, DDX11, DLGAP5, DSN1, ERCC6L, EXO1, GTSE1, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, MSH2, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, POLA1, POLD1, POLE, PSMC3IP, PTTG1, RAD54B, RAD54L, SMC2, SPAG5, SPC25, STMN1, TACC3, TIMELESS, TPX2, TTK, UBE2C, ZWINT	395	cell cycle process
GO:0000278	1.154e-33	12.05	71 ASPM, AURKA, AURKB, BIRC5, BLM, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CENPE, CENPF, CEP55, CHEK1, CIT, DDX11, DLGAP5, DSN1, ERCC6L, GTSE1, HELLS, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KNTC1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, POLA1, POLD1, POLE, PTTG1, SMC2, SPAG5, SPC25, STMN1, TIMELESS, TPX2, TTK, UBE2C, ZWINT	315	mitotic cell cycle
GO:0051301	7.370e-29	7.38	53 ASPM, AURKB, BLM, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDC7, CDCA3, CDCA8, CDK2, CENPE, CENPF, CENPO, CEP55, CIT, DSN1, ERCC6L, HELLS, KIF11, KIF20B, KIF23, KNTC1, LIG1, MAD2L1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PLK1, PTTG1, SMC2, SPAG5, SPC25, TIMELESS, UBE2C, ZWINT	193	cell division
GO:0006260	3.863e-21	6.921	44 BLM, BRCA1, BRCA2, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, CHEK1, DSCC1, DTL, EXO1, GINS1, GINS2, GINS3, GINS4, GMNN, HMGB2, LIG1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MSH2, ORC1L, ORC6L, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, RFC2, RFC3, RFC4, RNASEH2A	181	DNA replication
GO:0006259	1.134e-16	14.3	56 BLM, BRCA1, BRCA2, BRIP1, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, CHEK1, DSCC1, DTL, EXO1, FANCA, FANCG, FANCI, GINS1, GINS2, GINS3, GINS4, GMNN, HELLS, HMGB2, LIG1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MSH2, NEIL3, ORC1L, ORC6L, PARP2, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PSMC3IP, PTTG1, RAD51AP1, RAD54B, RAD54L, RFC2, RFC3, RFC4, RNASEH2A	374	DNA metabolic process
GO:0006996	3.114e-14	34.26	86 ASF1B, ASPM, AURKA, AURKB, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CDYL, CENPA, CENPE, CENPF, CEP55, CHAF1A, CHAF1B, CIT, CPA4, DDX11, DLGAP5, DSN1, ERCC6L, EXOSC9, EZH2, FANCG, HELLS, HIRIP3, HMGB2, IL1A, IL1B, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, MAD2L1, MCM2, MSH2, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PRKG1, PSRC1, PTTG1, RAD54L, RBL1, SMC2, SPAG5, SPC25, STMN1, SUV39H1, TACC3, TIMELESS, TMEM48, TPX2, TTK, UBE2C, WHSC1, WNT2, ZWINT	896	organelle organization
GO:0007017	5.574e-11	5.162	28 AURKA, BRCA1, BRCA2, BUB1B, CENPE, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, NDC80, NEK2, NUSAP1, PSRC1, SPAG5, STMN1, TACC3, TTK, UBE2C, WNT2, ZWINT	135	microtubule-based process
GO:0051726	6.237e-11	10.02	39 BLM, BMP2, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, CCNA2, CCNE2, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDKN3, CDT1, CENPF, CHEK1, DLGAP5, FANCG, GMNN, GTSE1, IL1A, IL1B, KIF20B, KNTC1, MAD2L1, MSH2, NEK2, NUSAP1, PKMYT1, RBL1, TACC3, TIMELESS, TP53BP2, TTK, UBE2C, ZWINT	262	regulation of cell cycle
GO:0007346	6.836e-11	3.403	23 BLM, BRCA2, BUB1, BUB1B, CCNA2, CDC25C, CDC6, CDK2, CDT1, CENPF, DLGAP5, GTSE1, IL1A, IL1B, KIF20B, KNTC1, MAD2L1, NEK2, NUSAP1, PKMYT1, TTK, UBE2C, ZWINT	89	regulation of mitotic cell cycle
GO:0007059	1.688e-10	1.759	17 BRCA1, CENPE, CENPF, CENPO, DDX11, DLGAP5, DSN1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, PTTG1, SMC2, ZWINT	46	chromosome segregation
GO:0000075	3.645e-10	2.103	18 BLM, BRIP1, BUB1, BUB1B, CCNA2, CCNE2, CDC45L, CDC6, CDT1, CENPF, CHEK1, FANCG, GTSE1, KNTC1, MAD2L1, MSH2, TTK, ZWINT	55	cell cycle checkpoint
GO:0006261	2.416e-09	2.333	18 CDC45L, CDC6, CDT1, EXO1, HMGB2, MCM2, MCM3, MCM4, MCM5, MCM7, MSH2, ORC1L, POLA1, POLD3, POLE2, PRIM1, RFC3, RFC4	61	DNA-dependent DNA replication
GO:0000070	3.240e-09	0.8795	12 CENPE, DDX11, DLGAP5, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, SMC2, ZWINT	23	mitotic sister chromatid segregation
GO:0000819	6.014e-09	0.9178	12 CENPE, DDX11, DLGAP5, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, SMC2, ZWINT	24	sister chromatid segregation
GO:0006974	2.627e-08	10.1	35 BARD1, BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHAF1A, CHAF1B, CHEK1, DTL, EXO1, FANCA, FANCG, FANCI, GTSE1, HMGB2, LIG1, MCM7, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RFC2, RFC3, RFC4, TIMELESS	264	response to DNA damage stimulus
GO:0000226	1.326e-07	2.944	18 AURKA, BRCA1, BRCA2, BUB1B, KIF11, KIF23, KIF2C, NDC80, NEK2, NUSAP1, PSRC1, SPAG5, STMN1, TACC3, TTK, UBE2C, WNT2, ZWINT	77	microtubule cytoskeleton organization
GO:0010564	1.633e-07	1.988	15 BRCA1, BRCA2, CDC25C, CDC7, CDT1, DLGAP5, IL1A, IL1B, KIF20B, KNTC1, NEK2, NUSAP1, PKMYT1, TIMELESS, UBE2C	52	regulation of cell cycle process
GO:0007051	1.987e-07	0.956	11 AURKA, BUB1B, KIF11, KIF23, NDC80, SPAG5, STMN1, TACC3, TTK, UBE2C, ZWINT	25	spindle organization
GO:0006281	2.129e-07	7.801	29 BLM, BRCA1, BRCA2, BRIP1, CHAF1A, CHAF1B, CHEK1, EXO1, FANCA, FANCG, FANCI, HMGB2, LIG1, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RFC2, RFC3, RFC4	204	DNA repair
GO:0006270	2.518e-07	0.7648	10 CDC45L, CDC6, CDT1, MCM2, MCM3, MCM4, MCM5, MCM7, ORC1L, POLA1	20	DNA replication initiation
GO:0034984	3.406e-07	8.986	31 BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHAF1A, CHAF1B, CHEK1, EXO1, FANCA, FANCG, FANCI, GTSE1, HMGB2, LIG1, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RFC2, RFC3, RFC4	235	cellular response to DNA damage stimulus
GO:0051325	5.065e-07	2.83	17 BLM, BRCA2, CCNE1, CDC25C, CDC6, CDC7, CDK2, CDKN3, CDT1, CENPF, CHEK1, DDX11, GTSE1, POLA1, POLD1, POLE, TIMELESS	74	interphase
GO:0051329	1.886e-06	2.715	16 BLM, BRCA2, CCNE1, CDC25C, CDC6, CDC7, CDK2, CDKN3, CDT1, CENPF, CHEK1, DDX11, GTSE1, POLA1, POLD1, POLE	71	interphase of mitotic cell cycle
GO:0016125	3.793e-06	2.486	15 C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, INSIG1, LDLR, LSS, MVD, SC4MOL, SQLE, SREBF1, SREBF2, TM7SF2	65	sterol metabolic process
GO:0016126	7.133e-06	1.3	11 C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, LSS, MVD, SC4MOL, SQLE, TM7SF2	34	sterol biosynthetic process
GO:0016043	7.946e-06	61.64	101 ADIPOR2, AGTR1, ASF1B, ASPM, AURKA, AURKB, BIRC5, BLM, BMP2, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNA2, CCNB1, CCNB2, CCNF, CDC20, CDC25A, CDC25C, CDC6, CDCA3, CDCA8, CDK2, CDYL, CENPA, CENPE, CENPF, CEP55, CHAF1A, CHAF1B, CIT, COL14A1, CPA4, DDX11, DLGAP5, DSN1, ERCC6L, EXOSC9, EZH2, FANCA, FANCG, GCH1, HELLS, HIRIP3, HMGB2, IL1A, IL1B, IL6, KIF11, KIF15, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KNTC1, LDLR, MAD2L1, MCM2, MSH2, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NEK2, NUSAP1, OIP5, PBK, PKMYT1, PLK1, PLSCR4, PRKG1, PSRC1, PTTG1, QPRT, RAD54L, RBL1, SLC1A3, SMC2, SPAG5, SPC25, STMN1, SUV39H1, TACC3, TGFBR1, TIMELESS, TMEM48, TNXB, TPX2, TTK, UBE2C, VCL, WHSC1, WNT2, ZWINT	1612	cellular component organization
GO:0051276	1.072e-05	10.48	31 ASF1B, BLM, BRCA2, CDYL, CENPA, CENPE, CENPF, CHAF1A, CHAF1B, CPA4, DDX11, DLGAP5, EZH2, HIRIP3, HMGB2, MCM2, MSH2, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NUSAP1, PTTG1, RAD54L, RBL1, SMC2, SUV39H1, WHSC1, ZWINT	274	chromosome organization
GO:0033554	1.450e-05	12.39	34 BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHAF1A, CHAF1B, CHEK1, EXO1, FADS1, FANCA, FANCG, FANCI, GTSE1, HMGB2, IL1B, LIG1, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RFC2, RFC3, RFC4, SREBF1	324	cellular response to stress
GO:0006297	1.772e-05	0.6501	8 LIG1, POLD1, POLD3, POLE, POLE2, RFC2, RFC3, RFC4	17	nucleotide-excision repair, DNA gap filling
GO:0007076	1.772e-05	0.4589	7 NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NUSAP1, SMC2	12	mitotic chromosome condensation
GO:0007093	2.034e-05	1.147	10 BLM, BUB1, BUB1B, CCNA2, CENPF, GTSE1, KNTC1, MAD2L1, TTK, ZWINT	30	mitotic cell cycle checkpoint
GO:0006694	2.777e-05	2.141	13 C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, LSS, MVD, SC4MOL, SQLE, TM7SF2	56	steroid biosynthetic process
GO:0051716	4.513e-05	13.04	34 BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHAF1A, CHAF1B, CHEK1, EXO1, FADS1, FANCA, FANCG, FANCI, GTSE1, HMGB2, IL1B, LIG1, MSH2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RFC2, RFC3, RFC4, SREBF1	341	cellular response to stimulus
GO:0008202	4.811e-05	4.321	18 AGTR1, C14orf1, CYP51A1, DHCR7, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, INSIG1, LDLR, LSS, MVD, SC4MOL, SQLE, SREBF1, SREBF2, TM7SF2	113	steroid metabolic process
GO:0006323	7.351e-05	2.333	13 ASF1B, CENPA, CHAF1A, CHAF1B, HMGB2, MCM2, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NUSAP1, SMC2	61	DNA packaging
GO:0030261	1.083e-04	0.5736	7 NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NUSAP1, SMC2	15	chromosome condensation
GO:0051320	1.083e-04	0.5736	7 BRCA2, CDC7, CDT1, DDX11, POLA1, POLD1, TIMELESS	15	S phase
GO:0031570	1.102e-04	1.071	9 BLM, BRIP1, CCNA2, CDC45L, CDC6, CDT1, CHEK1, GTSE1, MSH2	28	DNA integrity checkpoint
GO:0007088	1.171e-04	1.377	10 CDC25C, DLGAP5, IL1A, IL1B, KIF20B, KNTC1, NEK2, NUSAP1, PKMYT1, UBE2C	36	regulation of mitosis
GO:0008203	2.127e-04	2.18	12 CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, INSIG1, LDLR, LSS, MVD, SREBF1, SREBF2, TM7SF2	57	cholesterol metabolic process
GO:0030705	3.790e-04	2.715	13 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, MYO1E	71	cytoskeleton-dependent intracellular transport
GO:0007018	4.187e-04	2.333	12 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	61	microtubule-based movement
GO:0006695	4.217e-04	0.956	8 CYP51A1, DHCR7, HMGCR, HMGCS1, IDI1, LSS, MVD, TM7SF2	25	cholesterol biosynthetic process
GO:0000731	6.339e-04	0.3059	5 POLA1, POLD1, POLD3, POLE, RFC3	8	DNA synthesis during DNA repair
GO:0006302	8.769e-04	1.377	9 BLM, BRCA1, BRCA2, BRIP1, MSH2, POLA1, RAD51AP1, RAD54B, RAD54L	36	double-strand break repair
GO:0000724	1.011e-03	0.5354	6 BLM, BRCA1, BRCA2, RAD51AP1, RAD54B, RAD54L	14	double-strand break repair via homologous recombination
GO:0000725	1.011e-03	0.5354	6 BLM, BRCA1, BRCA2, RAD51AP1, RAD54B, RAD54L	14	recombinational repair
GO:0006289	1.434e-03	1.836	10 BRCA2, LIG1, NEIL3, POLD1, POLD3, POLE, POLE2, RFC2, RFC3, RFC4	48	nucleotide-excision repair
GO:0006066	2.061e-03	7.457	21 ALDOC, C14orf1, CYP51A1, DHCR7, GALNAC4S-6ST, GCH1, GDPD5, GFPT2, GPD2, HMGCR, HMGCS1, IDI1, INSIG1, LDLR, LSS, MVD, SC4MOL, SQLE, SREBF1, SREBF2, TM7SF2	195	cellular alcohol metabolic process
GO:0008610	4.039e-03	7.266	20 BRCA1, C14orf1, CYP51A1, DHCR7, FABP3, FADS1, FADS2, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, LSS, MVD, PIGB, PIGZ, SC4MOL, SCD, SQLE, TM7SF2	190	lipid biosynthetic process
GO:0048015	5.300e-03	1.759	9 AGTR1, AURKA, BUB1B, HMGB2, NDC80, RFC4, SPAG5, UBE2C, ZWINT	46	phosphoinositide-mediated signaling
GO:0000084	5.412e-03	0.4589	5 BRCA2, CDT1, DDX11, POLA1, POLD1	12	S phase of mitotic cell cycle
GO:0006271	5.882e-03	0.1147	3 POLA1, RFC3, RFC4	3	DNA strand elongation during DNA replication
GO:0051053	8.196e-03	1.109	7 BLM, BRCA2, CDC45L, CDC6, CDT1, GMNN, MSH2	29	negative regulation of DNA metabolic process
GO:0008283	8.812e-03	21.61	40 AGTR1, BLM, BMP2, BRCA1, BRCA2, BUB1, BUB1B, CDC25A, CDC25C, CDC6, CDC7, CDK2, CDKN3, CENPF, CHEK1, DDX11, DHCR7, DLGAP5, FABP3, GINS1, IL1A, IL1B, IL6, INSIG1, KIF15, KIF2C, MCM7, MKI67, PDGFD, PDGFRB, PLK1, POLA1, STIL, TACC3, TACSTD2, TGFBR1, TIMELESS, TPX2, TTK, WNT2	565	cell proliferation
GO:0045840	1.076e-02	0.5354	5 DLGAP5, IL1A, IL1B, NUSAP1, UBE2C	14	positive regulation of mitosis
GO:0044249	1.150e-02	89.02	118 AGTR1, ASF1B, ATAD2, ATF3, B3GNT2, BLM, BMP2, BRCA1, BRCA2, BRIP1, C14orf1, CCNA2, CCNE1, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CDYL, CENPF, CHAF1A, CHAF1B, CHEK1, CREB5, CYP51A1, DHCR7, DMD, DSCC1, DTL, DVL3, E2F8, EXO1, EZH2, FABP3, FADS1, FADS2, FOXM1, FRY, GALNAC4S-6ST, GCH1, GINS1, GINS2, GINS3, GINS4, GMNN, GPD2, HELLS, HIVEP1, HMGB2, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, IL1A, IL1B, IL6, INSIG1, ITGB3BP, KLF7, LDLR, LIG1, LMCD1, LSS, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MLF1IP, MSH2, MVD, NR4A3, ORC1L, ORC6L, PIGB, PIGZ, PIR, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PRPS2, PSRC1, PTTG1, QPRT, RAD54B, RBL1, REL, RFC2, RFC3, RFC4, RNASEH2A, RUNX1, SC4MOL, SCD, SKIL, SQLE, SREBF1, SREBF2, SUV39H1, TGFBR1, TIMELESS, TM7SF2, TRIP13, TRPS1, TSC22D3, TXNIP, WHSC1, ZNF85	2328	cellular biosynthetic process
GO:0008156	1.164e-02	0.8413	6 BLM, BRCA2, CDC45L, CDC6, CDT1, GMNN	22	negative regulation of DNA replication
GO:0009058	1.411e-02	90.48	119 AGTR1, ASF1B, ATAD2, ATF3, B3GNT2, BLM, BMP2, BRCA1, BRCA2, BRIP1, C14orf1, CCNA2, CCNE1, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CDYL, CENPF, CHAF1A, CHAF1B, CHEK1, CREB5, CYP51A1, DHCR7, DMD, DSCC1, DTL, DVL3, E2F8, EXO1, EZH2, FABP3, FADS1, FADS2, FOXM1, FRY, GALNAC4S-6ST, GCH1, GFPT2, GINS1, GINS2, GINS3, GINS4, GMNN, GPD2, HELLS, HIVEP1, HMGB2, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, IL1A, IL1B, IL6, INSIG1, ITGB3BP, KLF7, LDLR, LIG1, LMCD1, LSS, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MLF1IP, MSH2, MVD, NR4A3, ORC1L, ORC6L, PIGB, PIGZ, PIR, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PRPS2, PSRC1, PTTG1, QPRT, RAD54B, RBL1, REL, RFC2, RFC3, RFC4, RNASEH2A, RUNX1, SC4MOL, SCD, SKIL, SQLE, SREBF1, SREBF2, SUV39H1, TGFBR1, TIMELESS, TM7SF2, TRIP13, TRPS1, TSC22D3, TXNIP, WHSC1, ZNF85	2366	biosynthetic process
GO:0009987	1.576e-02	251.9	268 ADAMTS5, ADIPOR2, AGTR1, ALDOC, ANGPTL2, ANGPTL4, ANK2, ANXA3, AQP3, ARHGAP11A, ARHGAP19, ASF1B, ASPM, ATAD2, ATF3, AURKA, AURKB, B3GNT2, BARD1, BIRC5, BLM, BMP2, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C14orf1, C18orf24, C21orf45, CCL11, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDCA3, CDCA8, CDK2, CDKN3, CDT1, CDYL, CENPA, CENPE, CENPF, CENPO, CEP55, CHAF1A, CHAF1B, CHEK1, CIT, CKAP2, CLCN6, COL14A1, COL21A1, CORIN, CPA3, CPA4, CREB5, CSTF2, CXCR7, CYP51A1, DDX11, DEPDC1, DHCR7, DHFR, DHRS3, DLGAP5, DMD, DPYSL2, DRAM, DSCC1, DSN1, DTL, DVL3, E2F8, ECM2, ENOX1, ERCC6L, EXO1, EXOSC9, EZH2, FABP3, FADS1, FADS2, FANCA, FANCG, FANCI, FBXW7, FOXM1, FRY, GALNAC4S-6ST, GCH1, GDF15, GDPD5, GFPT2, GINS1, GINS2, GINS3, GINS4, GMNN, GPD2, GRIA3, GTSE1, HELLS, HERC6, HIRIP3, HIVEP1, HMGB2, HMGCR, HMGCS1, HSD17B2, HSD17B7, ICAM1, IDI1, IL1A, IL1B, IL6, INSIG1, ITGB3BP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KNTC1, LDLR, LIG1, LMCD1, LSS, MAD2L1, MAN1C1, MC4R, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MKI67, MLF1IP, MSH2, MVD, MX1, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NDRG1, NEIL3, NEK2, NR4A3, NUSAP1, OIP5, OMD, ORC1L, ORC6L, PAPPA, PARP2, PBK, PDGFD, PDGFRB, PIGB, PIGZ, PIR, PKMYT1, PLK1, PLK4, PLSCR4, PLXNC1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PPL, PPP3CC, PRELP, PRIM1, PRKG1, PRPS2, PRSS12, PSMC3IP, PSRC1, PTTG1, QPRT, RAB33A, RAD51AP1, RAD54B, RAD54L, RANGAP1, RASGRP1, RASGRP3, RBL1, REL, RFC2, RFC3, RFC4, RNASEH2A, ROR1, RRAGB, RUNX1, SC4MOL, SCD, SEMA3D, SGK1, SKIL, SLC1A3, SLC2A14, SLC2A3, SMC2, SMOX, SPAG5, SPC25, SQLE, SREBF1, SREBF2, SSX2IP, STIL, STK38L, STMN1, SUV39H1, SVEP1, TACC3, TACSTD2, TBC1D12, TGFBR1, TIMELESS, TM7SF2, TMEM48, TNFAIP6, TNXB, TP53BP2, TPX2, TRIP13, TRPC6, TRPS1, TSC22D3, TTK, TXNIP, UBE2C, UST, VCL, VRK1, WHSC1, WNT2, YOD1, ZNF85, ZWINT	6588	cellular process
GO:0007089	1.690e-02	0.153	3 CDC25C, CDC6, CDK2	4	traversing start control point of mitotic cell cycle
GO:0022616	1.690e-02	0.153	3 POLA1, RFC3, RFC4	4	DNA strand elongation
GO:0050000	1.690e-02	0.153	3 CENPE, CENPF, DLGAP5	4	chromosome localization
GO:0051303	1.690e-02	0.153	3 CENPE, CENPF, DLGAP5	4	establishment of chromosome localization
GO:0006310	1.811e-02	3.097	11 BLM, BRCA1, BRCA2, CHEK1, EXO1, LIG1, MSH2, PSMC3IP, RAD51AP1, RAD54B, RAD54L	81	DNA recombination
GO:0000079	1.957e-02	1.721	8 BLM, CCNE2, CDC25A, CDC25C, CDC6, CDKN3, CHEK1, PKMYT1	45	regulation of cyclin-dependent protein kinase activity
GO:0000077	2.090e-02	0.956	6 BLM, BRIP1, CCNA2, CHEK1, GTSE1, MSH2	25	DNA damage checkpoint
GO:0042770	2.200e-02	1.759	8 BLM, BRCA1, BRCA2, BRIP1, CCNA2, CHEK1, GTSE1, MSH2	46	DNA damage response, signal transduction
GO:0033261	2.519e-02	0.3824	4 BRCA2, CDC7, CDT1, TIMELESS	10	regulation of S phase
GO:0006950	2.806e-02	32.81	52 AGTR1, ANGPTL4, BARD1, BLM, BMP2, BRCA1, BRCA2, BRIP1, CCL11, CCNA2, CHAF1A, CHAF1B, CHEK1, DTL, EXO1, FADS1, FANCA, FANCG, FANCI, GCH1, GTSE1, HMGB2, IL1A, IL1B, IL6, LIG1, MCM7, MSH2, MX1, MX2, NEIL3, PARP2, POLA1, POLD1, POLD3, POLE, POLE2, POLQ, PTTG1, RAD51AP1, RAD54B, RAD54L, RFC2, RFC3, RFC4, SGK1, SLC1A3, SREBF1, TACC3, TIMELESS, TNFAIP6, TXNIP	858	response to stress
GO:0000085	3.239e-02	0.1912	3 BLM, CENPF, GTSE1	5	G2 phase of mitotic cell cycle
GO:0007094	3.239e-02	0.1912	3 BUB1, CENPF, TTK	5	mitotic cell cycle spindle assembly checkpoint
GO:0031577	3.239e-02	0.1912	3 BUB1, CENPF, TTK	5	spindle checkpoint
GO:0051319	3.239e-02	0.1912	3 BLM, CENPF, GTSE1	5	G2 phase
GO:0044255	3.338e-02	13.73	27 ADIPOR2, AGTR1, BRCA1, C14orf1, CYP51A1, DHCR7, DHRS3, FABP3, FADS1, FADS2, HMGCR, HMGCS1, HSD17B2, HSD17B7, IDI1, INSIG1, LDLR, LSS, MVD, PIGB, PIGZ, SC4MOL, SCD, SQLE, SREBF1, SREBF2, TM7SF2	359	cellular lipid metabolic process
GO:0006268	3.384e-02	0.4206	4 HMGB2, MCM2, MCM4, MCM7	11	DNA unwinding during replication
GO:0006720	3.529e-02	0.7266	5 DHRS3, HMGCR, HMGCS1, IDI1, MVD	19	isoprenoid metabolic process
GO:0007052	4.380e-02	0.4589	4 KIF11, KIF23, STMN1, TTK	12	mitotic spindle organization
GO:0006275	4.380e-02	1.568	7 BLM, BRCA2, CDC45L, CDC6, CDK2, CDT1, GMNN	41	regulation of DNA replication
GO:0051052	4.791e-02	2.562	9 BLM, BRCA1, BRCA2, CDC45L, CDC6, CDK2, CDT1, GMNN, MSH2	67	regulation of DNA metabolic process
GO:0045787	4.879e-02	1.185	6 BRCA2, DLGAP5, IL1A, IL1B, NUSAP1, UBE2C	31	positive regulation of cell cycle

Id	Pvalue	ExpCount	Count	Size	Term
GO:0044427	2.051e-25	7.343	50 ASF1B, AURKB, BLM, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHEK1, DSN1, ERCC6L, ITGB3BP, KIF22, KIF2C, KNTC1, MAD2L1, MCM2, MCM3, MCM7, MLF1IP, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, OIP5, ORC6L, POLA1, POLA2, POLD3, PRIM1, RANGAP1, RFC2, RFC3, RFC4, SMC2, SPAG5, SPC25, SUV39H1, TIMELESS, ZWINT	198	chromosomal part
GO:0005694	2.679e-24	9.197	54 ASF1B, AURKB, BIRC5, BLM, BRCA1, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHEK1, DSN1, ERCC6L, FANCI, HMGB2, ITGB3BP, KIF22, KIF2C, KNTC1, MAD2L1, MCM2, MCM3, MCM7, MLF1IP, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, OIP5, ORC6L, POLA1, POLA2, POLD3, PRIM1, RANGAP1, RFC2, RFC3, RFC4, SMC2, SPAG5, SPC25, SUV39H1, TIMELESS, ZWINT	248	chromosome
GO:0000775	4.026e-21	2.336	28 AURKB, BUB1, BUB1B, C18orf24, C21orf45, CDCA8, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, DSN1, ERCC6L, ITGB3BP, KIF22, KIF2C, KNTC1, MAD2L1, MLF1IP, NDC80, OIP5, RANGAP1, SPAG5, SPC25, SUV39H1, ZWINT	63	chromosome, centromeric region
GO:0000793	4.268e-18	2.448	26 BLM, BRCA1, BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, CHEK1, DSN1, ERCC6L, HMGB2, KNTC1, MLF1IP, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, RANGAP1, SMC2, SPAG5, SPC25, SUV39H1, ZWINT	66	condensed chromosome
GO:0043228	1.501e-12	50.06	104 ALDOC, ANGPTL4, ANK2, ASF1B, ATF3, AURKA, AURKB, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNB1, CCNB2, CDC20, CDC45L, CDC6, CDCA8, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHEK1, CKAP2, CSTF2, DDX11, DLGAP5, DMD, DPYSL2, DSN1, ERCC6L, EXOSC9, FANCI, GABARAPL1, GABARAPL3, GTSE1, HMGB2, ITGB3BP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LMNB1, MAD2L1, MCM2, MCM3, MCM4, MCM7, MKI67, MLF1IP, MYBL1, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NDRG1, NEK2, NUSAP1, OIP5, ORC6L, PARP2, PLK1, POLA1, POLA2, POLD3, PPL, PRIM1, PRKG1, PSRC1, RANGAP1, RFC2, RFC3, RFC4, SMC2, SNTB1, SPAG5, SPC25, STMN1, SUV39H1, TIMELESS, TPX2, TTK, VCL, WDHD1, ZWINT	1350	non-membrane-bounded organelle
GO:0043232	1.501e-12	50.06	104 ALDOC, ANGPTL4, ANK2, ASF1B, ATF3, AURKA, AURKB, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, C21orf45, CCNB1, CCNB2, CDC20, CDC45L, CDC6, CDCA8, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHEK1, CKAP2, CSTF2, DDX11, DLGAP5, DMD, DPYSL2, DSN1, ERCC6L, EXOSC9, FANCI, GABARAPL1, GABARAPL3, GTSE1, HMGB2, ITGB3BP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LMNB1, MAD2L1, MCM2, MCM3, MCM4, MCM7, MKI67, MLF1IP, MYBL1, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NDRG1, NEK2, NUSAP1, OIP5, ORC6L, PARP2, PLK1, POLA1, POLA2, POLD3, PPL, PRIM1, PRKG1, PSRC1, RANGAP1, RFC2, RFC3, RFC4, SMC2, SNTB1, SPAG5, SPC25, STMN1, SUV39H1, TIMELESS, TPX2, TTK, VCL, WDHD1, ZWINT	1350	intracellular non-membrane-bounded organelle
GO:0000777	1.928e-12	1.261	16 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, MLF1IP, NDC80, RANGAP1, SPAG5, SPC25, ZWINT	34	condensed chromosome kinetochore
GO:0000779	1.928e-12	1.261	16 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, DSN1, ERCC6L, KNTC1, MLF1IP, NDC80, RANGAP1, SPAG5, SPC25, ZWINT	34	condensed chromosome, centromeric region
GO:0000776	2.153e-12	1.706	18 BUB1, BUB1B, C18orf24, CENPA, CENPE, CENPF, CENPM, DSN1, ERCC6L, KIF22, KNTC1, MAD2L1, MLF1IP, NDC80, RANGAP1, SPAG5, SPC25, ZWINT	46	kinetochore
GO:0005819	7.786e-10	2.967	20 AURKA, AURKB, BUB1, BUB1B, C18orf24, CDC20, CDC6, CENPE, CENPF, DLGAP5, KIF11, KIF14, KIF15, KIF23, KIF4A, KNTC1, PSRC1, SPAG5, TPX2, TTK	80	spindle
GO:0005657	3.921e-09	0.9642	12 BLM, CDT1, CHEK1, MCM3, MCM7, POLA1, POLA2, POLD3, PRIM1, RFC2, RFC3, RFC4	26	replication fork
GO:0015630	4.267e-09	11.94	39 AURKA, AURKB, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, CCNB1, CCNB2, CDC20, CDC45L, CDC6, CENPE, CENPF, CKAP2, DLGAP5, GABARAPL1, GABARAPL3, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, NEK2, NUSAP1, PLK1, PSRC1, SPAG5, STMN1, TPX2, TTK	322	microtubule cytoskeleton
GO:0005634	1.233e-08	114.6	168 ADAMTS5, ANGPTL4, ARHGAP19, ASF1B, ASPM, ATAD2, ATF3, AURKA, AURKB, BARD1, BIRC5, BLM, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C12orf48, C21orf45, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDCA4, CDCA8, CDK2, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHAF1A, CHAF1B, CHEK1, CPA3, CREB5, CSTF2, DDX11, DEPDC1, DHCR7, DLGAP5, DMD, DSCC1, DSN1, DTL, E2F8, EXO1, EXOSC9, EZH2, FANCA, FANCG, FANCI, FBXW7, FOXM1, GCH1, GINS1, GINS2, GINS3, GINS4, GMNN, HELLS, HIRIP3, HIVEP1, HJURP, HMGB2, ITGB3BP, KIAA0586, KIF11, KIF14, KIF18A, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KNTC1, LIG1, LMCD1, LMNB1, MAD2L1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDM1, MKI67, MLF1IP, MSH2, MX2, MYBL1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NDRG1, NEIL3, NEK2, NR4A3, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PIR, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PPL, PRIM1, PRKG1, PSMC3IP, PTTG1, RAD51AP1, RAD54B, RAD54L, RANGAP1, RBL1, REL, RFC2, RFC3, RFC4, RNASEH2A, RRAGB, RUNX1, SGK1, SKIL, SMC2, SPC25, SREBF1, SREBF2, SSX2IP, SUV39H1, TIMELESS, TMEM48, TP53BP2, TPX2, TRIP13, TRPS1, UBE2C, VRK1, WDHD1, WHSC1, ZNF85, ZWINT	3091	nucleus
GO:0044446	3.461e-08	99.94	151 ABCA5, ANGPTL4, ASF1B, ATF3, ATP6V1G2, AURKA, AURKB, B3GNT2, BARD1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C14orf1, C18orf24, C21orf45, C4orf18, CCNA2, CCNB1, CCNE1, CCNE2, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHAF1A, CHAF1B, CHEK1, CKAP2, CSTF2, CYP51A1, DDX11, DHCR7, DLGAP5, DRAM, DSN1, DTL, E2F8, ENTPD7, ERCC6L, EXOSC9, EZH2, FADS1, FADS2, GABARAPL1, GABARAPL3, GALNAC4S-6ST, GMNN, GPD2, GTSE1, HMGB2, HMGCR, HSD17B2, HSD17B7, INSIG1, ITGB3BP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LDLR, LIG1, LMNB1, MAD2L1, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MKI67, MLF1IP, MSH2, MYBL1, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NEK2, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PIGB, PIGZ, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PRKG1, PSRC1, RANGAP1, RASGRP1, RBL1, RFC2, RFC3, RFC4, SC4MOL, SCD, SMC2, SPAG5, SPC25, SQLE, SREBF1, SREBF2, STMN1, SUV39H1, TIMELESS, TM7SF2, TMEM48, TPX2, TTK, UBE2C, UST, WDHD1, WNT2, ZWINT	2695	intracellular organelle part
GO:0044422	4.605e-08	100.3	151 ABCA5, ANGPTL4, ASF1B, ATF3, ATP6V1G2, AURKA, AURKB, B3GNT2, BARD1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, C14orf1, C18orf24, C21orf45, C4orf18, CCNA2, CCNB1, CCNE1, CCNE2, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDCA8, CDK2, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHAF1A, CHAF1B, CHEK1, CKAP2, CSTF2, CYP51A1, DDX11, DHCR7, DLGAP5, DRAM, DSN1, DTL, E2F8, ENTPD7, ERCC6L, EXOSC9, EZH2, FADS1, FADS2, GABARAPL1, GABARAPL3, GALNAC4S-6ST, GMNN, GPD2, GTSE1, HMGB2, HMGCR, HSD17B2, HSD17B7, INSIG1, ITGB3BP, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LDLR, LIG1, LMNB1, MAD2L1, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MKI67, MLF1IP, MSH2, MYBL1, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NEK2, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PIGB, PIGZ, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PRKG1, PSRC1, RANGAP1, RASGRP1, RBL1, RFC2, RFC3, RFC4, SC4MOL, SCD, SMC2, SPAG5, SPC25, SQLE, SREBF1, SREBF2, STMN1, SUV39H1, TIMELESS, TM7SF2, TMEM48, TPX2, TTK, UBE2C, UST, WDHD1, WNT2, ZWINT	2705	organelle part
GO:0005654	7.145e-08	21.14	52 BLM, BRCA1, BRCA2, CCNA2, CCNB1, CCNE1, CCNE2, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CHAF1A, CHAF1B, CHEK1, E2F8, EZH2, GMNN, KIF20A, KIF20B, KIF23, LIG1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, RBL1, RFC2, RFC3, RFC4, SUV39H1, UBE2C, WDHD1	570	nucleoplasm
GO:0000228	1.844e-07	2.855	17 BLM, BUB1, CHEK1, HMGB2, MCM2, MCM3, MCM7, NCAPD2, NCAPD3, ORC6L, POLA1, POLA2, POLD3, PRIM1, SMC2, SUV39H1, TIMELESS	77	nuclear chromosome
GO:0044430	7.143e-07	15.58	41 AURKA, AURKB, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, CCNB1, CDC20, CDC45L, CDC6, CENPE, CENPF, CKAP2, DLGAP5, GABARAPL1, GABARAPL3, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LMNB1, MYO19, MYO1E, NEK2, NUSAP1, PLK1, PSRC1, SPAG5, STMN1, TPX2, TTK	420	cytoskeletal part
GO:0031981	1.019e-06	32.08	65 ANGPTL4, ATF3, BIRC5, BLM, BRCA1, BRCA2, CCNA2, CCNB1, CCNE1, CCNE2, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CSTF2, DDX11, E2F8, EXOSC9, EZH2, GMNN, HMGB2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MKI67, MYBL1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PRKG1, RBL1, RFC2, RFC3, RFC4, SUV39H1, UBE2C, WDHD1	865	nuclear lumen
GO:0044428	1.272e-06	42.05	78 ANGPTL4, ATF3, BARD1, BIRC5, BLM, BRCA1, BRCA2, BUB1, BUB1B, CCNA2, CCNB1, CCNE1, CCNE2, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CSTF2, DDX11, DHCR7, DTL, E2F8, EXOSC9, EZH2, GMNN, HMGB2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MKI67, MSH2, MYBL1, NCAPD2, NCAPD3, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PRKG1, RANGAP1, RBL1, RFC2, RFC3, RFC4, SMC2, SREBF1, SUV39H1, TIMELESS, TMEM48, UBE2C, WDHD1	1134	nuclear part
GO:0000796	2.557e-05	0.2225	5 NCAPD2, NCAPD3, NCAPG, NCAPH, SMC2	6	condensin complex
GO:0005874	2.999e-05	5.488	20 CENPE, CKAP2, GABARAPL1, GABARAPL3, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, NUSAP1, SPAG5, STMN1	148	microtubule
GO:0044454	5.135e-05	2.114	12 BLM, BUB1, MCM2, MCM3, MCM7, NCAPD3, ORC6L, POLA1, POLA2, POLD3, PRIM1, TIMELESS	57	nuclear chromosome part
GO:0043596	5.797e-05	0.4079	6 MCM3, MCM7, POLA1, POLA2, POLD3, PRIM1	11	nuclear replication fork
GO:0005856	8.927e-05	25.92	51 ALDOC, ANK2, AURKA, AURKB, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, CCNB1, CCNB2, CDC20, CDC45L, CDC6, CENPE, CENPF, CKAP2, DLGAP5, DMD, DPYSL2, GABARAPL1, GABARAPL3, GTSE1, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, LMNB1, MYO19, MYO1E, NCAPH, NDRG1, NEK2, NUSAP1, PLK1, PPL, PSRC1, SNTB1, SPAG5, STMN1, TPX2, TTK, VCL	699	cytoskeleton
GO:0005875	2.289e-04	2.448	12 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	66	microtubule associated complex
GO:0043234	2.855e-04	44.32	73 ATP6V1G2, BARD1, BIRC5, BRCA1, BRCA2, BUB1, BUB1B, C18orf24, CDCA8, CDK2, CENPA, CENPE, CENPF, CENPM, CHAF1A, CHAF1B, DMD, DSN1, E2F8, ERCC6L, EXOSC9, EZH2, GCH1, GPD2, IL6, KCNB1, KCND3, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KNTC1, MAD2L1, MCM2, MCM3, MCM7, MLF1IP, MSH2, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPH, NDC80, NEK2, ORC6L, POLA1, POLA2, POLD3, PRIM1, RANGAP1, RBL1, RFC2, RFC3, RFC4, SMC2, SNTB1, SPAG5, SPC25, SSX2IP, SUV39H1, TGFBR1, TMEM48, VCL, ZWINT	1195	protein complex
GO:0030894	3.672e-04	0.3338	5 MCM3, POLA1, POLA2, POLD3, PRIM1	9	replisome
GO:0043601	3.672e-04	0.3338	5 MCM3, POLA1, POLA2, POLD3, PRIM1	9	nuclear replisome
GO:0005658	4.289e-04	0.1854	4 MCM3, POLA1, POLA2, PRIM1	5	alpha DNA polymerase:primase complex
GO:0070013	8.205e-04	39.27	65 ANGPTL4, ATF3, BIRC5, BLM, BRCA1, BRCA2, CCNA2, CCNB1, CCNE1, CCNE2, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CSTF2, DDX11, E2F8, EXOSC9, EZH2, GMNN, HMGB2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MKI67, MYBL1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PRKG1, RBL1, RFC2, RFC3, RFC4, SUV39H1, UBE2C, WDHD1	1059	intracellular organelle lumen
GO:0043233	1.293e-03	39.9	65 ANGPTL4, ATF3, BIRC5, BLM, BRCA1, BRCA2, CCNA2, CCNB1, CCNE1, CCNE2, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CSTF2, DDX11, E2F8, EXOSC9, EZH2, GMNN, HMGB2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MKI67, MYBL1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PRKG1, RBL1, RFC2, RFC3, RFC4, SUV39H1, UBE2C, WDHD1	1076	organelle lumen
GO:0000940	1.973e-03	0.1113	3 BUB1B, CENPE, CENPF	3	outer kinetochore of condensed chromosome
GO:0000922	2.335e-03	0.7417	6 BUB1, CENPF, DLGAP5, KIF11, KNTC1, TPX2	20	spindle pole
GO:0031974	2.397e-03	40.83	65 ANGPTL4, ATF3, BIRC5, BLM, BRCA1, BRCA2, CCNA2, CCNB1, CCNE1, CCNE2, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CDT1, CENPF, CHAF1A, CHAF1B, CHEK1, CSTF2, DDX11, E2F8, EXOSC9, EZH2, GMNN, HMGB2, KIF20A, KIF20B, KIF23, KIF4A, LIG1, LMNB1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MKI67, MYBL1, OIP5, ORC1L, ORC6L, PARP2, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PRIM1, PRKG1, RBL1, RFC2, RFC3, RFC4, SUV39H1, UBE2C, WDHD1	1101	membrane-enclosed lumen
GO:0005871	1.428e-02	0.4079	4 KIF11, KIF15, KIF23, KIF2C	11	kinesin complex
GO:0000794	1.825e-02	0.7417	5 BLM, BUB1, CHEK1, NCAPD3, SUV39H1	20	condensed nuclear chromosome
GO:0032993	1.889e-02	1.113	6 CENPA, MCM3, POLA1, POLA2, POLD3, PRIM1	30	protein-DNA complex
GO:0005663	2.415e-02	0.2225	3 RFC2, RFC3, RFC4	6	DNA replication factor C complex
GO:0031436	3.305e-02	0.07417	2 BARD1, BRCA1	2	BRCA1-BARD1 complex
GO:0000785	3.500e-02	3.263	10 ASF1B, CDYL, CENPA, CENPF, MCM2, MCM7, OIP5, POLA1, SUV39H1, TIMELESS	88	chromatin
GO:0043226	3.971e-02	194.7	218 ABCA5, ABHD10, ADAMTS5, ALDOC, ANGPTL4, ANK2, ARHGAP19, ASF1B, ASPM, ATAD2, ATF3, ATP6V1G2, AURKA, AURKB, B3GNT2, BARD1, BIRC5, BLM, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C12orf48, C14orf1, C18orf24, C21orf45, C4orf18, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDCA4, CDCA8, CDK2, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHAF1A, CHAF1B, CHEK1, CKAP2, CPA3, CREB5, CSTF2, CYP51A1, DDX11, DEPDC1, DHCR7, DLGAP5, DMD, DPYSL2, DRAM, DSCC1, DSN1, DTL, E2F8, ENTPD7, ERCC6L, EXO1, EXOSC9, EZH2, FADS1, FADS2, FANCA, FANCG, FANCI, FBXW7, FOXM1, GABARAPL1, GABARAPL3, GALNAC4S-6ST, GCH1, GDF15, GINS1, GINS2, GINS3, GINS4, GMNN, GPD2, GTSE1, HELLS, HIRIP3, HIVEP1, HJURP, HMGB2, HMGCR, HSD17B2, HSD17B7, IDI1, IL1B, INSIG1, ITGB3BP, KIAA0586, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KNTC1, LDLR, LIG1, LMCD1, LMNB1, MAD2L1, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDM1, MKI67, MLF1IP, MSH2, MX2, MYBL1, MYO19, MYO1E, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NDRG1, NEIL3, NEK2, NR4A3, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PIGB, PIGZ, PIR, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PPL, PRIM1, PRKG1, PSMC3IP, PSRC1, PTTG1, RAD51AP1, RAD54B, RAD54L, RANGAP1, RASGRP1, RBL1, REL, RFC2, RFC3, RFC4, RNASEH2A, RRAGB, RUNX1, SC4MOL, SCD, SGK1, SKIL, SMC2, SNTB1, SPAG5, SPC25, SQLE, SREBF1, SREBF2, SSX2IP, STMN1, SUV39H1, TIMELESS, TM7SF2, TMEM48, TP53BP2, TPX2, TRIP13, TRPS1, TTK, UBE2C, UST, VCL, VRK1, WDHD1, WHSC1, WNT2, ZNF85, ZWINT	5249	organelle
GO:0043231	3.997e-02	176.7	201 ABCA5, ABHD10, ADAMTS5, ALDOC, ANGPTL4, ARHGAP19, ASF1B, ASPM, ATAD2, ATF3, ATP6V1G2, AURKA, AURKB, B3GNT2, BARD1, BIRC5, BLM, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C12orf48, C14orf1, C21orf45, C4orf18, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDCA4, CDCA8, CDK2, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHAF1A, CHAF1B, CHEK1, CPA3, CREB5, CSTF2, CYP51A1, DDX11, DEPDC1, DHCR7, DLGAP5, DMD, DPYSL2, DRAM, DSCC1, DSN1, DTL, E2F8, ENTPD7, EXO1, EXOSC9, EZH2, FADS1, FADS2, FANCA, FANCG, FANCI, FBXW7, FOXM1, GABARAPL1, GALNAC4S-6ST, GCH1, GDF15, GINS1, GINS2, GINS3, GINS4, GMNN, GPD2, HELLS, HIRIP3, HIVEP1, HJURP, HMGB2, HMGCR, HSD17B2, HSD17B7, IDI1, INSIG1, ITGB3BP, KIAA0586, KIF11, KIF14, KIF18A, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KNTC1, LDLR, LIG1, LMCD1, LMNB1, MAD2L1, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDM1, MKI67, MLF1IP, MSH2, MX2, MYBL1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NDRG1, NEIL3, NEK2, NR4A3, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PIGB, PIGZ, PIR, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PPL, PRIM1, PRKG1, PSMC3IP, PTTG1, RAD51AP1, RAD54B, RAD54L, RANGAP1, RASGRP1, RBL1, REL, RFC2, RFC3, RFC4, RNASEH2A, RRAGB, RUNX1, SC4MOL, SCD, SGK1, SKIL, SMC2, SPC25, SQLE, SREBF1, SREBF2, SSX2IP, SUV39H1, TIMELESS, TM7SF2, TMEM48, TP53BP2, TPX2, TRIP13, TRPS1, UBE2C, UST, VRK1, WDHD1, WHSC1, WNT2, ZNF85, ZWINT	4765	intracellular membrane-bounded organelle
GO:0043227	4.081e-02	176.8	201 ABCA5, ABHD10, ADAMTS5, ALDOC, ANGPTL4, ARHGAP19, ASF1B, ASPM, ATAD2, ATF3, ATP6V1G2, AURKA, AURKB, B3GNT2, BARD1, BIRC5, BLM, BRCA1, BRCA2, BRIP1, BUB1, BUB1B, C12orf48, C14orf1, C21orf45, C4orf18, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CCNF, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDCA4, CDCA8, CDK2, CDT1, CDYL, CENPA, CENPE, CENPF, CENPI, CENPM, CENPO, CENPQ, CHAF1A, CHAF1B, CHEK1, CPA3, CREB5, CSTF2, CYP51A1, DDX11, DEPDC1, DHCR7, DLGAP5, DMD, DPYSL2, DRAM, DSCC1, DSN1, DTL, E2F8, ENTPD7, EXO1, EXOSC9, EZH2, FADS1, FADS2, FANCA, FANCG, FANCI, FBXW7, FOXM1, GABARAPL1, GALNAC4S-6ST, GCH1, GDF15, GINS1, GINS2, GINS3, GINS4, GMNN, GPD2, HELLS, HIRIP3, HIVEP1, HJURP, HMGB2, HMGCR, HSD17B2, HSD17B7, IDI1, INSIG1, ITGB3BP, KIAA0586, KIF11, KIF14, KIF18A, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, KLF7, KNTC1, LDLR, LIG1, LMCD1, LMNB1, MAD2L1, MAN1C1, MCM10, MCM2, MCM3, MCM4, MCM5, MCM7, MDM1, MKI67, MLF1IP, MSH2, MX2, MYBL1, NCAPD2, NCAPD3, NCAPG, NCAPG2, NCAPH, NDC80, NDRG1, NEIL3, NEK2, NR4A3, NUSAP1, OIP5, ORC1L, ORC6L, PARP2, PIGB, PIGZ, PIR, PKMYT1, PLK1, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ, PPL, PRIM1, PRKG1, PSMC3IP, PTTG1, RAD51AP1, RAD54B, RAD54L, RANGAP1, RASGRP1, RBL1, REL, RFC2, RFC3, RFC4, RNASEH2A, RRAGB, RUNX1, SC4MOL, SCD, SGK1, SKIL, SMC2, SPC25, SQLE, SREBF1, SREBF2, SSX2IP, SUV39H1, TIMELESS, TM7SF2, TMEM48, TP53BP2, TPX2, TRIP13, TRPS1, UBE2C, UST, VRK1, WDHD1, WHSC1, WNT2, ZNF85, ZWINT	4767	membrane-bounded organelle

Id	Pvalue	ExpCount	Count	Size	Term
GO:0003777	4.150e-06	1.34	12 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A	37	microtubule motor activity
GO:0005524	2.353e-05	29.3	60 ABCA5, ATAD2, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DDX11, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MCM2, MCM3, MCM5, MCM7, MKI67, MSH2, MVD, MYO19, MYO1E, NEK2, ORC1L, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAD54B, RAD54L, RFC2, RFC4, ROR1, SGK1, SMC2, STK38L, TGFBR1, TPX2, TRIP13, TTK, UBE2C, VRK1	809	ATP binding
GO:0032559	3.220e-05	29.62	60 ABCA5, ATAD2, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DDX11, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MCM2, MCM3, MCM5, MCM7, MKI67, MSH2, MVD, MYO19, MYO1E, NEK2, ORC1L, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAD54B, RAD54L, RFC2, RFC4, ROR1, SGK1, SMC2, STK38L, TGFBR1, TPX2, TRIP13, TTK, UBE2C, VRK1	818	adenyl ribonucleotide binding
GO:0030554	3.833e-05	31.29	62 ABCA5, ATAD2, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DDX11, ERCC6L, GALNAC4S-6ST, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MCM2, MCM3, MCM5, MCM7, MKI67, MSH2, MVD, MYO19, MYO1E, NEK2, ORC1L, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAD54B, RAD54L, RFC2, RFC4, ROR1, SGK1, SMC2, SQLE, STK38L, TGFBR1, TPX2, TRIP13, TTK, UBE2C, VRK1	864	adenyl nucleotide binding
GO:0003774	8.612e-05	2.571	14 CENPE, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, MYO19, MYO1E	71	motor activity
GO:0000166	4.790e-04	46.17	77 ABCA5, ATAD2, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, CSTF2, DDX11, DHRS3, ENOX1, ERCC6L, GALNAC4S-6ST, GCH1, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MCM2, MCM3, MCM4, MCM5, MCM7, MKI67, MSH2, MVD, MX1, MX2, MYO19, MYO1E, NEK2, ORC1L, PBK, PDGFRB, PKMYT1, PLK1, PLK4, POLA1, POLD1, POLE, POLQ, PRKG1, RAB33A, RAD54B, RAD54L, RFC2, RFC3, RFC4, ROR1, RRAGB, SGK1, SKIL, SMC2, SQLE, STK38L, TGFBR1, TPX2, TRIP13, TTK, UBE2C, VRK1	1275	nucleotide binding
GO:0032553	5.001e-04	36.65	65 ABCA5, ATAD2, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DDX11, ERCC6L, GCH1, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MCM2, MCM3, MCM5, MCM7, MKI67, MSH2, MVD, MX1, MX2, MYO19, MYO1E, NEK2, ORC1L, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAB33A, RAD54B, RAD54L, RFC2, RFC4, ROR1, RRAGB, SGK1, SMC2, STK38L, TGFBR1, TPX2, TRIP13, TTK, UBE2C, VRK1	1012	ribonucleotide binding
GO:0032555	5.001e-04	36.65	65 ABCA5, ATAD2, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DDX11, ERCC6L, GCH1, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MCM2, MCM3, MCM5, MCM7, MKI67, MSH2, MVD, MX1, MX2, MYO19, MYO1E, NEK2, ORC1L, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAB33A, RAD54B, RAD54L, RFC2, RFC4, ROR1, RRAGB, SGK1, SMC2, STK38L, TGFBR1, TPX2, TRIP13, TTK, UBE2C, VRK1	1012	purine ribonucleotide binding
GO:0003887	5.110e-04	0.6518	7 POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ	18	DNA-directed DNA polymerase activity
GO:0017076	5.615e-04	38.39	67 ABCA5, ATAD2, AURKA, AURKB, BLM, BRIP1, BUB1, BUB1B, CDC6, CDC7, CDK2, CENPE, CHEK1, CIT, DDX11, ERCC6L, GALNAC4S-6ST, GCH1, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, LIG1, MCM2, MCM3, MCM5, MCM7, MKI67, MSH2, MVD, MX1, MX2, MYO19, MYO1E, NEK2, ORC1L, PDGFRB, PKMYT1, PLK1, PLK4, POLQ, PRKG1, RAB33A, RAD54B, RAD54L, RFC2, RFC4, ROR1, RRAGB, SGK1, SMC2, SQLE, STK38L, TGFBR1, TPX2, TRIP13, TTK, UBE2C, VRK1	1060	purine nucleotide binding
GO:0017111	1.239e-03	16.33	36 ABCA5, ATAD2, BLM, BRIP1, CDC6, CENPE, DDX11, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, MCM3, MCM4, MCM7, MSH2, MX1, MX2, MYO19, MYO1E, ORC1L, RAB33A, RAD54B, RAD54L, RFC2, RFC3, RFC4, TRIP13	451	nucleoside-triphosphatase activity
GO:0034061	1.303e-03	0.7605	7 POLA1, POLA2, POLD1, POLD3, POLE, POLE2, POLQ	21	DNA polymerase activity
GO:0016817	1.397e-03	17.13	37 ABCA5, ATAD2, ATP6V1G2, BLM, BRIP1, CDC6, CENPE, DDX11, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, MCM3, MCM4, MCM7, MSH2, MX1, MX2, MYO19, MYO1E, ORC1L, RAB33A, RAD54B, RAD54L, RFC2, RFC3, RFC4, TRIP13	473	hydrolase activity, acting on acid anhydrides
GO:0016462	2.576e-03	17.02	36 ABCA5, ATAD2, BLM, BRIP1, CDC6, CENPE, DDX11, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, MCM3, MCM4, MCM7, MSH2, MX1, MX2, MYO19, MYO1E, ORC1L, RAB33A, RAD54B, RAD54L, RFC2, RFC3, RFC4, TRIP13	470	pyrophosphatase activity
GO:0016818	2.783e-03	17.09	36 ABCA5, ATAD2, BLM, BRIP1, CDC6, CENPE, DDX11, ERCC6L, HELLS, KIF11, KIF14, KIF15, KIF18A, KIF18B, KIF20A, KIF20B, KIF22, KIF23, KIF2C, KIF4A, MCM3, MCM4, MCM7, MSH2, MX1, MX2, MYO19, MYO1E, ORC1L, RAB33A, RAD54B, RAD54L, RFC2, RFC3, RFC4, TRIP13	472	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0003682	4.830e-03	2.933	12 CDC6, CDYL, CENPA, CENPF, CHAF1A, CHAF1B, HELLS, POLA1, POLD1, POLE, SUV39H1, SVEP1	81	chromatin binding
GO:0008094	3.479e-02	1.412	7 BLM, BRIP1, DDX11, RAD54B, RFC2, RFC3, RFC4	39	DNA-dependent ATPase activity
GO:0003689	3.557e-02	0.1811	3 RFC2, RFC3, RFC4	5	DNA clamp loader activity
GO:0033170	3.557e-02	0.1811	3 RFC2, RFC3, RFC4	5	DNA-protein loading ATPase activity
GO:0003697	3.910e-02	1.449	7 BLM, BRCA2, HMGB2, MCM4, MCM7, MSH2, RAD51AP1	40	single-stranded DNA binding

Id	Pvalue	ExpCount	Count	Size	Term
04110	2.950e-12	4.53	27 BUB1, BUB1B, CCNA2, CCNB1, CCNB2, CCNE1, CCNE2, CDC20, CDC25A, CDC25C, CDC45L, CDC6, CDC7, CDK2, CHEK1, MAD2L1, MCM2, MCM3, MCM4, MCM5, MCM7, ORC1L, ORC6L, PKMYT1, PLK1, PTTG1, RBL1	98	Cell cycle
03030	3.140e-12	1.525	17 LIG1, MCM2, MCM3, MCM4, MCM5, MCM7, POLA1, POLA2, POLD1, POLD3, POLE, POLE2, PRIM1, RFC2, RFC3, RFC4, RNASEH2A	33	DNA replication
00100	5.629e-06	1.063	10 CYP51A1, DHCR7, HMGCR, HSD17B7, IDI1, LSS, MVD, SC4MOL, SQLE, TM7SF2	23	Biosynthesis of steroids
03430	5.372e-04	1.017	8 EXO1, LIG1, MSH2, POLD1, POLD3, RFC2, RFC3, RFC4	22	Mismatch repair
03410	2.267e-02	1.387	7 LIG1, NEIL3, PARP2, POLD1, POLD3, POLE, POLE2	30	Base excision repair
03420	2.511e-02	1.849	8 LIG1, POLD1, POLD3, POLE, POLE2, RFC2, RFC3, RFC4	40	Nucleotide excision repair
03440	4.302e-02	1.156	6 BLM, BRCA2, POLD1, POLD3, RAD54B, RAD54L	25	Homologous recombination

No enriched terms

No enriched terms

Entrez genes

ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (213353_at), score: 0.77 ABHD10abhydrolase domain containing 10 (218633_x_at), score: -0.59 ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif, 5 (219935_at), score: 0.66 ADIPOR2adiponectin receptor 2 (201346_at), score: 0.67 AGTR1angiotensin II receptor, type 1 (205357_s_at), score: 0.68 ALDOCaldolase C, fructose-bisphosphate (202022_at), score: 0.67 ANGPTL2angiopoietin-like 2 (213001_at), score: 0.74 ANGPTL4angiopoietin-like 4 (221009_s_at), score: 0.67 ANK2ankyrin 2, neuronal (202920_at), score: 0.83 ANXA3annexin A3 (209369_at), score: 0.67 APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B (206632_s_at), score: -0.6 AQP3aquaporin 3 (Gill blood group) (39248_at), score: 0.67 ARHGAP11ARho GTPase activating protein 11A (204492_at), score: -0.65 ARHGAP19Rho GTPase activating protein 19 (212738_at), score: -0.61 ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae) (218115_at), score: -0.71 ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila) (219918_s_at), score: -0.67 ASPNasporin (219087_at), score: 0.69 ATAD2ATPase family, AAA domain containing 2 (218782_s_at), score: -0.63 ATF3activating transcription factor 3 (202672_s_at), score: 0.66 ATP6V1G2ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 (214762_at), score: 0.71 AURKAaurora kinase A (208079_s_at), score: -0.67 AURKBaurora kinase B (209464_at), score: -0.74 B3GNT2UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (219326_s_at), score: 0.72 BARD1BRCA1 associated RING domain 1 (205345_at), score: -0.72 BIRC5baculoviral IAP repeat-containing 5 (202095_s_at), score: -0.7 BLMBloom syndrome (205733_at), score: -0.68 BMP2bone morphogenetic protein 2 (205289_at), score: 0.66 BRCA1breast cancer 1, early onset (204531_s_at), score: -0.69 BRCA2breast cancer 2, early onset (208368_s_at), score: -0.6 BRIP1BRCA1 interacting protein C-terminal helicase 1 (221703_at), score: -0.74 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: -0.75 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (203755_at), score: -0.72 C12orf48chromosome 12 open reading frame 48 (220060_s_at), score: -0.65 C14orf1chromosome 14 open reading frame 1 (202562_s_at), score: 0.74 C17orf91chromosome 17 open reading frame 91 (214696_at), score: 0.82 C18orf24chromosome 18 open reading frame 24 (217640_x_at), score: -0.75 C1orf112chromosome 1 open reading frame 112 (220840_s_at), score: -0.6 C1orf135chromosome 1 open reading frame 135 (220011_at), score: -0.74 C21orf45chromosome 21 open reading frame 45 (219004_s_at), score: -0.78 C4orf18chromosome 4 open reading frame 18 (219872_at), score: 0.78 C9orf40chromosome 9 open reading frame 40 (218904_s_at), score: -0.61 CCDC15coiled-coil domain containing 15 (220466_at), score: -0.69 CCL11chemokine (C-C motif) ligand 11 (210133_at), score: 0.82 CCNA2cyclin A2 (203418_at), score: -0.72 CCNB1cyclin B1 (214710_s_at), score: -0.62 CCNB2cyclin B2 (202705_at), score: -0.64 CCNE1cyclin E1 (213523_at), score: -0.61 CCNE2cyclin E2 (205034_at), score: -0.75 CCNFcyclin F (204826_at), score: -0.66 CDC20cell division cycle 20 homolog (S. cerevisiae) (202870_s_at), score: -0.69 CDC25Acell division cycle 25 homolog A (S. pombe) (204695_at), score: -0.68 CDC25Ccell division cycle 25 homolog C (S. pombe) (205167_s_at), score: -0.62 CDC45LCDC45 cell division cycle 45-like (S. cerevisiae) (204126_s_at), score: -0.73 CDC6cell division cycle 6 homolog (S. cerevisiae) (203967_at), score: -0.76 CDC7cell division cycle 7 homolog (S. cerevisiae) (204510_at), score: -0.8 CDCA3cell division cycle associated 3 (221436_s_at), score: -0.68 CDCA4cell division cycle associated 4 (218399_s_at), score: -0.62 CDCA8cell division cycle associated 8 (221520_s_at), score: -0.74 CDK2cyclin-dependent kinase 2 (204252_at), score: -0.78 CDKN3cyclin-dependent kinase inhibitor 3 (209714_s_at), score: -0.63 CDT1chromatin licensing and DNA replication factor 1 (209832_s_at), score: -0.7 CDYLchromodomain protein, Y-like (203100_s_at), score: 0.71 CENPAcentromere protein A (204962_s_at), score: -0.69 CENPEcentromere protein E, 312kDa (205046_at), score: -0.72 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: -0.71 CENPIcentromere protein I (214804_at), score: -0.71 CENPMcentromere protein M (218741_at), score: -0.77 CENPOcentromere protein O (219472_at), score: -0.59 CENPQcentromere protein Q (219294_at), score: -0.67 CEP55centrosomal protein 55kDa (218542_at), score: -0.62 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: -0.74 CHAF1Bchromatin assembly factor 1, subunit B (p60) (204775_at), score: -0.7 CHEK1CHK1 checkpoint homolog (S. pombe) (205393_s_at), score: -0.62 CITcitron (rho-interacting, serine/threonine kinase 21) (212801_at), score: -0.69 CKAP2cytoskeleton associated protein 2 (218252_at), score: -0.75 CLCN6chloride channel 6 (203950_s_at), score: 0.7 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: 0.82 COL21A1collagen, type XXI, alpha 1 (208096_s_at), score: 0.86 CORINcorin, serine peptidase (220356_at), score: 0.77 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: 0.92 CPA4carboxypeptidase A4 (205832_at), score: 0.71 CREB5cAMP responsive element binding protein 5 (205931_s_at), score: 0.66 CSTF2cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa (204459_at), score: -0.6 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: 0.73 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: 0.7 DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) (208149_x_at), score: -0.69 DEPDC1DEP domain containing 1 (220295_x_at), score: -0.76 DHCR77-dehydrocholesterol reductase (201790_s_at), score: 0.91 DHFRdihydrofolate reductase (202533_s_at), score: -0.69 DHRS3dehydrogenase/reductase (SDR family) member 3 (202481_at), score: 0.67 DLEU2deleted in lymphocytic leukemia 2 (non-protein coding) (216870_x_at), score: -0.71 DLEU2Ldeleted in lymphocytic leukemia 2-like (215629_s_at), score: -0.75 DLGAP5discs, large (Drosophila) homolog-associated protein 5 (203764_at), score: -0.67 DMDdystrophin (203881_s_at), score: 0.7 DPYSL2dihydropyrimidinase-like 2 (200762_at), score: 0.67 DRAMdamage-regulated autophagy modulator (218627_at), score: 0.69 DSCC1defective in sister chromatid cohesion 1 homolog (S. cerevisiae) (219000_s_at), score: -0.67 DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (219512_at), score: -0.88 DTLdenticleless homolog (Drosophila) (218585_s_at), score: -0.73 DVL3dishevelled, dsh homolog 3 (Drosophila) (201908_at), score: 0.7 E2F8E2F transcription factor 8 (219990_at), score: -0.67 ECM2extracellular matrix protein 2, female organ and adipocyte specific (206101_at), score: 0.77 ENOX1ecto-NOX disulfide-thiol exchanger 1 (219501_at), score: 0.68 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: 0.67 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (219650_at), score: -0.73 ERI2exoribonuclease 2 (213365_at), score: -0.7 EXO1exonuclease 1 (204603_at), score: -0.71 EXOSC9exosome component 9 (205061_s_at), score: -0.73 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: -0.82 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: 1 FADS1fatty acid desaturase 1 (208962_s_at), score: 0.79 FADS2fatty acid desaturase 2 (202218_s_at), score: 0.73 FAM64Afamily with sequence similarity 64, member A (221591_s_at), score: -0.69 FANCAFanconi anemia, complementation group A (203805_s_at), score: -0.62 FANCGFanconi anemia, complementation group G (203564_at), score: -0.72 FANCIFanconi anemia, complementation group I (213007_at), score: -0.65 FBXW7F-box and WD repeat domain containing 7 (218751_s_at), score: 0.66 FOXM1forkhead box M1 (202580_x_at), score: -0.63 FRYfurry homolog (Drosophila) (204072_s_at), score: 0.88 GABARAPL1GABA(A) receptor-associated protein like 1 (208868_s_at), score: 0.72 GABARAPL3GABA(A) receptors associated protein like 3 (pseudogene) (211458_s_at), score: 0.69 GALNAC4S-6STB cell RAG associated protein (203066_at), score: 0.81 GCH1GTP cyclohydrolase 1 (204224_s_at), score: 0.73 GDF15growth differentiation factor 15 (221577_x_at), score: 0.7 GDPD5glycerophosphodiester phosphodiesterase domain containing 5 (32502_at), score: 0.69 GFPT2glutamine-fructose-6-phosphate transaminase 2 (205100_at), score: 0.67 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: -0.72 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: -0.76 GINS3GINS complex subunit 3 (Psf3 homolog) (45633_at), score: -0.78 GINS4GINS complex subunit 4 (Sld5 homolog) (211767_at), score: -0.66 GMNNgeminin, DNA replication inhibitor (218350_s_at), score: -0.66 GPD2glycerol-3-phosphate dehydrogenase 2 (mitochondrial) (210007_s_at), score: -0.64 GRIA3glutamate receptor, ionotrophic, AMPA 3 (206730_at), score: 0.65 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: 0.67 GSTM5glutathione S-transferase mu 5 (205752_s_at), score: 0.66 GTSE1G-2 and S-phase expressed 1 (204318_s_at), score: -0.71 HELLShelicase, lymphoid-specific (220085_at), score: -0.74 HERC6hect domain and RLD 6 (219352_at), score: 0.75 HIRIP3HIRA interacting protein 3 (204504_s_at), score: -0.59 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: 0.76 HJURPHolliday junction recognition protein (218726_at), score: -0.72 HMGB2high-mobility group box 2 (208808_s_at), score: -0.67 HMGCR3-hydroxy-3-methylglutaryl-Coenzyme A reductase (202540_s_at), score: 0.72 HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) (221750_at), score: 0.75 HMMRhyaluronan-mediated motility receptor (RHAMM) (207165_at), score: -0.67 HSD17B2hydroxysteroid (17-beta) dehydrogenase 2 (204818_at), score: 0.7 HSD17B7hydroxysteroid (17-beta) dehydrogenase 7 (220081_x_at), score: 0.66 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: 0.83 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: 0.85 IL1Ainterleukin 1, alpha (210118_s_at), score: 0.72 IL1Binterleukin 1, beta (39402_at), score: 0.76 IL6interleukin 6 (interferon, beta 2) (205207_at), score: 0.76 INSIG1insulin induced gene 1 (201627_s_at), score: 0.95 ITGB3BPintegrin beta 3 binding protein (beta3-endonexin) (205176_s_at), score: -0.68 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: 0.71 KCNB1potassium voltage-gated channel, Shab-related subfamily, member 1 (211006_s_at), score: 0.71 KCND3potassium voltage-gated channel, Shal-related subfamily, member 3 (213832_at), score: 0.89 KIAA0586KIAA0586 (205631_at), score: -0.62 KIF11kinesin family member 11 (204444_at), score: -0.73 KIF14kinesin family member 14 (206364_at), score: -0.75 KIF15kinesin family member 15 (219306_at), score: -0.72 KIF18Akinesin family member 18A (221258_s_at), score: -0.7 KIF18Bkinesin family member 18B (222039_at), score: -0.82 KIF20Akinesin family member 20A (218755_at), score: -0.59 KIF20Bkinesin family member 20B (205235_s_at), score: -0.69 KIF22kinesin family member 22 (202183_s_at), score: -0.68 KIF23kinesin family member 23 (204709_s_at), score: -0.62 KIF2Ckinesin family member 2C (209408_at), score: -0.71 KIF4Akinesin family member 4A (218355_at), score: -0.76 KLF7Kruppel-like factor 7 (ubiquitous) (204334_at), score: 0.75 KNTC1kinetochore associated 1 (206316_s_at), score: -0.72 LDLRlow density lipoprotein receptor (202068_s_at), score: 0.7 LIG1ligase I, DNA, ATP-dependent (202726_at), score: -0.67 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.83 LMNB1lamin B1 (203276_at), score: -0.73 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: 0.79 LSSlanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (211019_s_at), score: 0.9 LZTFL1leucine zipper transcription factor-like 1 (218437_s_at), score: 0.74 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: -0.77 MAMLD1mastermind-like domain containing 1 (205088_at), score: 0.68 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: 0.67 MC4Rmelanocortin 4 receptor (221467_at), score: -0.65 MCM10minichromosome maintenance complex component 10 (220651_s_at), score: -0.83 MCM2minichromosome maintenance complex component 2 (202107_s_at), score: -0.7 MCM3minichromosome maintenance complex component 3 (201555_at), score: -0.66 MCM4minichromosome maintenance complex component 4 (212141_at), score: -0.7 MCM5minichromosome maintenance complex component 5 (216237_s_at), score: -0.71 MCM7minichromosome maintenance complex component 7 (210983_s_at), score: -0.66 MDM1Mdm1 nuclear protein homolog (mouse) (213761_at), score: -0.67 MKI67antigen identified by monoclonal antibody Ki-67 (212022_s_at), score: -0.71 MLF1IPMLF1 interacting protein (218883_s_at), score: -0.64 MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (209421_at), score: -0.65 MVDmevalonate (diphospho) decarboxylase (203027_s_at), score: 0.84 MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) (202086_at), score: 0.67 MX2myxovirus (influenza virus) resistance 2 (mouse) (204994_at), score: 0.65 MYBL1v-myb myeloblastosis viral oncogene homolog (avian)-like 1 (213906_at), score: -0.63 MYO19myosin XIX (219320_at), score: -0.63 MYO1Emyosin IE (203072_at), score: 0.66 NASPnuclear autoantigenic sperm protein (histone-binding) (201970_s_at), score: -0.63 NCAPD2non-SMC condensin I complex, subunit D2 (201774_s_at), score: -0.62 NCAPD3non-SMC condensin II complex, subunit D3 (212789_at), score: -0.66 NCAPGnon-SMC condensin I complex, subunit G (218663_at), score: -0.71 NCAPG2non-SMC condensin II complex, subunit G2 (219588_s_at), score: -0.66 NCAPHnon-SMC condensin I complex, subunit H (212949_at), score: -0.71 NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae) (204162_at), score: -0.66 NDRG1N-myc downstream regulated 1 (200632_s_at), score: 0.67 NEIL3nei endonuclease VIII-like 3 (E. coli) (219502_at), score: -0.69 NEK2NIMA (never in mitosis gene a)-related kinase 2 (204641_at), score: -0.68 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: 0.66 NUSAP1nucleolar and spindle associated protein 1 (218039_at), score: -0.65 OIP5Opa interacting protein 5 (213599_at), score: -0.73 OLFML2Aolfactomedin-like 2A (213075_at), score: 0.74 OMDosteomodulin (205907_s_at), score: 0.67 ORAI3ORAI calcium release-activated calcium modulator 3 (221864_at), score: 0.65 ORC1Lorigin recognition complex, subunit 1-like (yeast) (205085_at), score: -0.72 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: -0.82 PAPPApregnancy-associated plasma protein A, pappalysin 1 (201981_at), score: 0.78 PARP2poly (ADP-ribose) polymerase 2 (214086_s_at), score: -0.65 PBKPDZ binding kinase (219148_at), score: -0.61 PDGFDplatelet derived growth factor D (219304_s_at), score: 0.71 PDGFRBplatelet-derived growth factor receptor, beta polypeptide (202273_at), score: 0.77 PIGBphosphatidylinositol glycan anchor biosynthesis, class B (214151_s_at), score: 0.68 PIGZphosphatidylinositol glycan anchor biosynthesis, class Z (220041_at), score: 0.67 PIRpirin (iron-binding nuclear protein) (207469_s_at), score: 0.66 PKMYT1protein kinase, membrane associated tyrosine/threonine 1 (204267_x_at), score: -0.69 PLK1polo-like kinase 1 (Drosophila) (202240_at), score: -0.62 PLK4polo-like kinase 4 (Drosophila) (204887_s_at), score: -0.64 PLSCR4phospholipid scramblase 4 (218901_at), score: 0.69 PLXNC1plexin C1 (213241_at), score: 0.82 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: -0.8 POLA2polymerase (DNA directed), alpha 2 (70kD subunit) (204441_s_at), score: -0.66 POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa (203422_at), score: -0.71 POLD3polymerase (DNA-directed), delta 3, accessory subunit (212836_at), score: -0.65 POLEpolymerase (DNA directed), epsilon (216026_s_at), score: -0.67 POLE2polymerase (DNA directed), epsilon 2 (p59 subunit) (205909_at), score: -0.78 POLQpolymerase (DNA directed), theta (219510_at), score: -0.72 PPLperiplakin (203407_at), score: 0.95 PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (207000_s_at), score: 0.79 PRELPproline/arginine-rich end leucine-rich repeat protein (204223_at), score: 0.68 PRIM1primase, DNA, polypeptide 1 (49kDa) (205053_at), score: -0.81 PRKG1protein kinase, cGMP-dependent, type I (207119_at), score: 0.93 PRPS2phosphoribosyl pyrophosphate synthetase 2 (203401_at), score: -0.67 PRSS12protease, serine, 12 (neurotrypsin, motopsin) (205515_at), score: 0.68 PSMC3IPPSMC3 interacting protein (213951_s_at), score: -0.77 PSRC1proline/serine-rich coiled-coil 1 (201896_s_at), score: -0.63 PTTG1pituitary tumor-transforming 1 (203554_x_at), score: -0.63 QPRTquinolinate phosphoribosyltransferase (204044_at), score: 0.83 RAB33ARAB33A, member RAS oncogene family (206039_at), score: 0.7 RAD51AP1RAD51 associated protein 1 (204146_at), score: -0.66 RAD54BRAD54 homolog B (S. cerevisiae) (219494_at), score: -0.8 RAD54LRAD54-like (S. cerevisiae) (204558_at), score: -0.67 RANGAP1Ran GTPase activating protein 1 (212125_at), score: -0.65 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: 0.86 RASGRP3RAS guanyl releasing protein 3 (calcium and DAG-regulated) (205801_s_at), score: -0.59 RBL1retinoblastoma-like 1 (p107) (205296_at), score: -0.74 RELv-rel reticuloendotheliosis viral oncogene homolog (avian) (206036_s_at), score: 0.69 RFC2replication factor C (activator 1) 2, 40kDa (203696_s_at), score: -0.62 RFC3replication factor C (activator 1) 3, 38kDa (204127_at), score: -0.76 RFC4replication factor C (activator 1) 4, 37kDa (204023_at), score: -0.66 RFWD3ring finger and WD repeat domain 3 (218564_at), score: -0.61 RNASEH2Aribonuclease H2, subunit A (203022_at), score: -0.7 ROR1receptor tyrosine kinase-like orphan receptor 1 (205805_s_at), score: 0.66 RRAGBRas-related GTP binding B (205540_s_at), score: 0.74 RUNX1runt-related transcription factor 1 (209360_s_at), score: 0.68 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: 0.95 SCDstearoyl-CoA desaturase (delta-9-desaturase) (200832_s_at), score: 0.85 SEMA3Dsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D (215324_at), score: 0.7 SGK1serum/glucocorticoid regulated kinase 1 (201739_at), score: 0.69 SHCBP1SHC SH2-domain binding protein 1 (219493_at), score: -0.63 SKILSKI-like oncogene (206675_s_at), score: 0.67 SLC19A1solute carrier family 19 (folate transporter), member 1 (211576_s_at), score: -0.64 SLC1A3solute carrier family 1 (glial high affinity glutamate transporter), member 3 (202800_at), score: 0.67 SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14 (222088_s_at), score: 0.85 SLC2A3solute carrier family 2 (facilitated glucose transporter), member 3 (202499_s_at), score: 0.68 SLC2A3P1solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 (221751_at), score: 0.79 SLC46A3solute carrier family 46, member 3 (214719_at), score: 0.66 SMC2structural maintenance of chromosomes 2 (204240_s_at), score: -0.71 SMOXspermine oxidase (210357_s_at), score: 0.71 SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) (214708_at), score: 0.68 SPAG5sperm associated antigen 5 (203145_at), score: -0.73 SPATA2Lspermatogenesis associated 2-like (214965_at), score: 0.68 SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) (209891_at), score: -0.71 SQLEsqualene epoxidase (213562_s_at), score: 0.98 SREBF1sterol regulatory element binding transcription factor 1 (202308_at), score: 0.66 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: 0.83 SSX2IPsynovial sarcoma, X breakpoint 2 interacting protein (203016_s_at), score: -0.64 STILSCL/TAL1 interrupting locus (205339_at), score: -0.74 STK38Lserine/threonine kinase 38 like (212572_at), score: 0.85 STMN1stathmin 1/oncoprotein 18 (200783_s_at), score: -0.61 SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila) (218619_s_at), score: -0.64 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: 0.74 TACC3transforming, acidic coiled-coil containing protein 3 (218308_at), score: -0.71 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: 0.89 TBC1D12TBC1 domain family, member 12 (221858_at), score: 0.72 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: 0.78 TIMELESStimeless homolog (Drosophila) (203046_s_at), score: -0.73 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: 0.68 TM7SF2transmembrane 7 superfamily member 2 (210130_s_at), score: 0.83 TMEM194Atransmembrane protein 194A (212621_at), score: -0.81 TMEM48transmembrane protein 48 (218073_s_at), score: -0.65 TNFAIP6tumor necrosis factor, alpha-induced protein 6 (206026_s_at), score: 0.69 TNXAtenascin XA pseudogene (213451_x_at), score: 0.7 TNXBtenascin XB (216333_x_at), score: 0.67 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: 0.68 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (210052_s_at), score: -0.7 TRIP13thyroid hormone receptor interactor 13 (204033_at), score: -0.69 TRPC6transient receptor potential cation channel, subfamily C, member 6 (217287_s_at), score: 0.73 TRPS1trichorhinophalangeal syndrome I (218502_s_at), score: 0.65 TSC22D3TSC22 domain family, member 3 (208763_s_at), score: 0.75 TTC17tetratricopeptide repeat domain 17 (218972_at), score: 0.75 TTKTTK protein kinase (204822_at), score: -0.8 TXNIPthioredoxin interacting protein (201008_s_at), score: -0.61 UBE2Cubiquitin-conjugating enzyme E2C (202954_at), score: -0.61 USTuronyl-2-sulfotransferase (205139_s_at), score: 0.66 VCLvinculin (200930_s_at), score: 0.72 VRK1vaccinia related kinase 1 (203856_at), score: -0.62 WDHD1WD repeat and HMG-box DNA binding protein 1 (216228_s_at), score: -0.7 WDR76WD repeat domain 76 (205519_at), score: -0.68 WHSC1Wolf-Hirschhorn syndrome candidate 1 (209053_s_at), score: -0.65 WNT2wingless-type MMTV integration site family member 2 (205648_at), score: 0.75 WRAP53WD repeat containing, antisense to TP53 (44563_at), score: -0.65 YOD1YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) (215150_at), score: 0.68 YPEL5yippee-like 5 (Drosophila) (217783_s_at), score: 0.72 ZNF85zinc finger protein 85 (206572_x_at), score: -0.62 ZWINTZW10 interactor (204026_s_at), score: -0.61

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
E-TABM-263-raw-cel-1515486291.cel	33	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486351.cel	36	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486271.cel	32	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486331.cel	35	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486231.cel	30	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485851.cel	11	6	Cycle	hgu133a2	none	Cycle 1