Previous module | Next module Module #879, TG: 2.2, TC: 2, 265 probes, 265 Entrez genes, 5 conditions

Help | Hide | Top Help | Show | Top Expression data

skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

blood vessel development

The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

cell activation

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

antigen processing and presentation of peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

cell motion

Any process involved in the controlled movement of a cell.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

intracellular signaling cascade

A series of reactions within the cell that occur as a result of a single trigger reaction or compound.

protein kinase cascade

A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of protein kinase cascade

Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of protein kinase cascade

Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

cell migration

The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.

antigen processing and presentation

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

muscle cell proliferation

The expansion of a muscle cell population by cell division.

regulation of tissue remodeling

Any process that modulates the frequency, rate, or extent of tissue remodeling.

locomotion

Self-propelled movement of a cell or organism from one location to another.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

leukocyte activation

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

regulation of osteoblast differentiation

Any process that modulates the frequency, rate or extent of osteoblast differentiation.

positive regulation of osteoblast differentiation

Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.

bone remodeling

The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.

regulation of bone remodeling

Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.

antigen processing and presentation of peptide antigen

The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

smooth muscle cell proliferation

The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.

regulation of smooth muscle cell proliferation

Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

tissue remodeling

The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

localization of cell

Any process by which a cell is transported to, and/or maintained in, a specific location.

cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

This term is the most general term possible

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

leukocyte activation

A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

regulation of tissue remodeling

Any process that modulates the frequency, rate, or extent of tissue remodeling.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

cell motion

Any process involved in the controlled movement of a cell.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

regulation of bone remodeling

Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.

regulation of osteoblast differentiation

Any process that modulates the frequency, rate or extent of osteoblast differentiation.

positive regulation of osteoblast differentiation

Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.

regulation of osteoblast differentiation

Any process that modulates the frequency, rate or extent of osteoblast differentiation.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

regulation of smooth muscle cell proliferation

Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.

positive regulation of osteoblast differentiation

Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

regulation of protein kinase cascade

Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

positive regulation of protein kinase cascade

Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

positive regulation of protein kinase cascade

Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

lytic vacuole

A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

cell surface

The external part of the cell wall and/or plasma membrane.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

calcium ion binding

Interacting selectively with calcium ions (Ca2+).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.

serine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

metal ion binding

Interacting selectively with any metal ion.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

peptidase activity, acting on L-amino acid peptides

Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

serine hydrolase activity

Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

MHC class I receptor activity

Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.

ion binding

Interacting selectively with ions, charged atoms or groups of atoms.

cation binding

Interacting selectively with cations, charged atoms or groups of atoms with a net positive charge.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

This term is the most general term possible

calcium ion binding

Interacting selectively with calcium ions (Ca2+).

serine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

serine-type endopeptidase activity

Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Id	Pvalue	ExpCount	Count	Size	Term
GO:0002376	3.224e-10	15.43	48 C1R, C1S, CBFB, CBLB, CCL2, CCRL1, CD55, CFHR1, CSF1, DNASE2, DPP4, EDN1, ERAP1, FAS, GEM, GPR183, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, HOXB7, ICAM1, IL11, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, ITGA1, JARID2, LIF, LY96, NFIL3, NFKB1, NP, OSTM1, PSMB8, RUNX1, SCG2, SOX4, TNFSF4, TPD52, TRIM22, VEGFA, ZEB1	475	immune system process
GO:0032501	2.817e-09	53.53	100 ACVR1, ADRA2A, ANGPTL4, ANO1, BHLHE40, BMPR2, CBFB, CCL2, COL15A1, CORIN, CREG1, CSF1, CST3, DCN, DES, DGKD, DKK2, DNASE2, EDN1, EGR2, EGR3, ERAP1, F10, F3, FAS, FGF1, FGF2, FGF5, FGF7, FOSB, FURIN, GAA, GAP43, GPNMB, GRIK2, HBEGF, HEXA, HHEX, HK2, HLX, HMOX1, HOXB5, HOXB6, HOXB7, HSPB7, HTR2A, HTR2B, IDUA, IL11, IL23A, IL6, IL6ST, IL8, ITPR3, JARID2, JUND, KCNN4, LBH, LIF, MAN2B1, MAP1S, MEIS1, NFKB1, NINJ1, NP, NR3C1, NR4A3, NRXN3, OSTM1, PDGFA, PDLIM3, PLAUR, PPARD, PROS1, RPS4Y1, RUNX1, SCG2, SEMA5A, SFRP1, SLC19A2, SLC1A1, SOX4, SPRED2, SPRY2, SPRY4, SRF, STBD1, TBX3, TCTN1, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, UTP3, VDR, VEGFA, WWTR1, ZMYM6	1648	multicellular organismal process
GO:0009605	1.463e-08	12.02	39 ACVR1, BHLHE40, C1R, C1S, CCL2, CCRL1, CD55, CFHR1, EDN1, EGR2, F10, F3, FGF2, FGF7, GAP43, HBEGF, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, ITGA1, JMJD3, LY96, NFKB1, NINJ1, NPC1, NR4A3, PDGFA, PLAUR, PPARD, PROS1, SCG2, SLC10A3, SRF, TGM2, TPST1, VEGFA	370	response to external stimulus
GO:0009611	2.020e-08	7.504	30 ACVR1, C1R, C1S, CCL2, CD55, CFHR1, EDN1, F10, F3, FGF7, GAP43, HBEGF, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, LY96, NFKB1, NINJ1, PDGFA, PLAUR, PPARD, PROS1, SCG2, SRF, TGM2, TPST1	231	response to wounding
GO:0048513	9.778e-08	24.14	57 ACVR1, ANGPTL4, BMPR2, CBFB, CCL2, COL15A1, CSF1, CST3, DCN, DNASE2, EDN1, EGR2, EGR3, ERAP1, FAS, FGF1, FGF2, FGF7, GAA, GAP43, GPNMB, HBEGF, HHEX, HMOX1, HOXB5, HOXB6, HOXB7, HTR2B, IDUA, IL11, IL6, IL8, JARID2, LIF, MAP1S, NFKB1, NINJ1, NP, NR3C1, NR4A3, OSTM1, PDLIM3, PPARD, RUNX1, SCG2, SEMA5A, SOX4, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, VDR, VEGFA	743	organ development
GO:0007275	2.691e-07	41.71	80 ACVR1, ANGPTL4, ANO1, BMPR2, CBFB, CCL2, COL15A1, CREG1, CSF1, CST3, DCN, DGKD, DKK2, DNASE2, EDN1, EGR2, EGR3, ERAP1, FAS, FGF1, FGF2, FGF5, FGF7, FOSB, GAA, GAP43, GPNMB, HBEGF, HEXA, HHEX, HLX, HMOX1, HOXB5, HOXB6, HOXB7, HTR2B, IDUA, IL11, IL6, IL6ST, IL8, JARID2, JUND, LBH, LIF, MAP1S, MEIS1, NFKB1, NINJ1, NP, NR3C1, NR4A3, NRXN3, OSTM1, PDGFA, PDLIM3, PPARD, RPS4Y1, RUNX1, SCG2, SEMA5A, SFRP1, SOX4, SPRED2, SPRY2, SPRY4, SRF, TBX3, TCTN1, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, UTP3, VDR, VEGFA, WWTR1, ZMYM6	1284	multicellular organismal development
GO:0032502	4.106e-07	61.82	104 ACVR1, ANGPTL4, ANO1, BMPR2, CASP1, CASP4, CBFB, CCL2, CDC42SE1, COL15A1, CORIN, CREG1, CSF1, CST3, DCN, DGKD, DKK2, DNASE2, DRAM, EDN1, EGR2, EGR3, ERAP1, FAS, FGF1, FGF2, FGF5, FGF7, FOSB, FURIN, GAA, GAP43, GNPTAB, GPNMB, GRIK2, HBEGF, HEXA, HHEX, HIPK3, HLX, HMOX1, HOXB5, HOXB6, HOXB7, HTR2A, HTR2B, HTRA1, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JUND, LBH, LIF, LIMS1, LITAF, MAP1S, MEIS1, MTSS1, NFKB1, NINJ1, NP, NR3C1, NR4A3, NRXN3, OSTM1, PDGFA, PDLIM3, PPARD, RPS4Y1, RUNX1, SCG2, SCML2, SEMA5A, SERPINB2, SETX, SFRP1, SOX4, SPRED2, SPRY2, SPRY4, SRF, SULF1, TBX3, TCTN1, TGM2, TM2D1, TNFAIP2, TNFRSF11B, TNS3, TP53BP2, TPD52, TPP1, TRAF3, UTP3, VDR, VEGFA, VEGFB, WWTR1, ZMYM6	1903	developmental process
GO:0006955	1.473e-06	9.583	31 C1R, C1S, CBLB, CCL2, CCRL1, CD55, CFHR1, ERAP1, FAS, GEM, GPR183, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, LIF, LY96, NFIL3, PSMB8, TNFSF4, TRIM22, ZEB1	295	immune response
GO:0008284	2.241e-06	6.139	24 ADRA2A, CCL2, CSF1, EDN1, FGF1, FGF2, FGF7, HBEGF, HTR2A, IL11, IL6, IL6ST, LIF, NAMPT, NP, PDGFA, SCG2, SOX4, TBX3, TGM2, TNFSF4, TNS3, VEGFA, VEGFB	189	positive regulation of cell proliferation
GO:0048518	3.732e-06	28.2	59 ABLIM3, ACVR1, ADRA2A, ANGPTL4, BMPR2, C1R, C1S, CASP1, CASP4, CBFB, CCL2, CD55, CFHR1, CSF1, ECM1, EDN1, EGR2, ERAP1, FAS, FGF1, FGF2, FGF7, FURIN, GRIK2, HBEGF, HHEX, HMOX1, HTR2A, HTR2B, ICAM1, IL11, IL6, IL6ST, IL8, JUND, KCNN4, LIF, LITAF, MAP3K7IP2, NAMPT, NFKB1, NP, NR4A3, PDGFA, PPARD, RUNX1, SCG2, SOX4, SRF, TBX3, TGM2, TM2D1, TNFSF4, TNS3, TP53BP2, TRAF3, VEGFA, VEGFB, WWTR1	868	positive regulation of biological process
GO:0042127	4.418e-06	12.38	35 ADRA2A, BMPR2, CCL2, CSF1, EDN1, FGF1, FGF2, FGF7, GPNMB, HBEGF, HHEX, HMOX1, HTR2A, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, LIF, NAMPT, NP, PDGFA, PPAP2A, SCG2, SOX4, TBX3, TGM2, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA, VEGFB	381	regulation of cell proliferation
GO:0009887	5.127e-06	10.13	31 ACVR1, ANGPTL4, CCL2, COL15A1, CST3, DCN, EDN1, ERAP1, FGF1, FGF2, GAA, HHEX, HMOX1, HOXB5, HOXB6, HOXB7, IDUA, IL6, IL8, JARID2, NR4A3, SCG2, SEMA5A, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, VDR, VEGFA	312	organ morphogenesis
GO:0050896	5.646e-06	43.85	79 ACVR1, ADRA2A, ANGPTL4, BHLHE40, C1R, C1S, CBLB, CCL2, CCRL1, CD55, CFHR1, CST3, DGKD, DPP4, EDN1, EGR2, ERAP1, F10, F3, FAS, FGF2, FGF7, FOSB, GAA, GAP43, GEM, GPR183, GPX3, GRIK2, H2BFS, HBEGF, HEXA, HIST1H2BK, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, HSPB7, HTR2A, ICAM1, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, ITGA1, JMJD3, KCNN4, LGALS3BP, LIF, LY96, MAN2B1, MAP3K4, NFIL3, NFKB1, NINJ1, NPC1, NR3C1, NR4A3, PDGFA, PLAUR, PPARD, PROS1, PSMB8, SCG2, SETX, SLC10A3, SRF, TGM2, TNFSF4, TP53I11, TPST1, TRIB1, TRIM22, VEGFA, ZEB1	1350	response to stimulus
GO:0048856	6.659e-06	40.05	74 ACVR1, ANGPTL4, BMPR2, CBFB, CCL2, CDC42SE1, COL15A1, CORIN, CSF1, CST3, DCN, DGKD, DNASE2, EDN1, EGR2, EGR3, ERAP1, FAS, FGF1, FGF2, FGF5, FGF7, GAA, GAP43, GPNMB, HBEGF, HEXA, HHEX, HMOX1, HOXB5, HOXB6, HOXB7, HTR2B, HTRA1, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JUND, LIF, MAP1S, MTSS1, NFKB1, NINJ1, NP, NR3C1, NR4A3, NRXN3, OSTM1, PDLIM3, PPARD, RUNX1, SCG2, SCML2, SEMA5A, SFRP1, SOX4, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, VDR, VEGFA, VEGFB, WWTR1	1233	anatomical structure development
GO:0051239	8.886e-06	10.39	31 ACVR1, ANGPTL4, BHLHE40, BMPR2, CSF1, CST3, DES, EDN1, EGR2, ERAP1, FAS, FGF2, FURIN, GAA, GRIK2, HBEGF, HHEX, HMOX1, HSPB7, HTR2A, IL6, IL6ST, JUND, LIF, NFKB1, NP, PDGFA, RUNX1, SRF, TBX3, TNFRSF11B	320	regulation of multicellular organismal process
GO:0048731	1.037e-05	32.78	64 ACVR1, ANGPTL4, BMPR2, CBFB, CCL2, COL15A1, CSF1, CST3, DCN, DNASE2, EDN1, EGR2, EGR3, ERAP1, FAS, FGF1, FGF2, FGF5, FGF7, GAA, GAP43, GPNMB, HBEGF, HEXA, HHEX, HMOX1, HOXB5, HOXB6, HOXB7, HTR2B, IDUA, IL11, IL6, IL6ST, IL8, JARID2, JUND, LIF, MAP1S, NFKB1, NINJ1, NP, NR3C1, NR4A3, NRXN3, OSTM1, PDLIM3, PPARD, RUNX1, SCG2, SEMA5A, SOX4, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, VDR, VEGFA, WWTR1	1009	system development
GO:0048514	1.917e-05	4.028	18 ACVR1, ANGPTL4, COL15A1, CST3, EDN1, ERAP1, FGF1, FGF2, HHEX, HMOX1, IL6, IL8, SCG2, SEMA5A, SRF, TGM2, TNFAIP2, VEGFA	124	blood vessel morphogenesis
GO:0006928	3.135e-05	8.738	27 ACVR1, ADRA2A, CCL2, CSF1, EDN1, EGR2, FGF2, GAP43, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, MTSS1, NRXN3, PDGFA, PLAUR, PPAP2A, PPARD, SCG2, SEMA5A, SRF, TNS3, TRIB1, VEGFA	269	cell motion
GO:0051674	3.135e-05	8.738	27 ACVR1, ADRA2A, CCL2, CSF1, EDN1, EGR2, FGF2, GAP43, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, MTSS1, NRXN3, PDGFA, PLAUR, PPAP2A, PPARD, SCG2, SEMA5A, SRF, TNS3, TRIB1, VEGFA	269	localization of cell
GO:0001525	4.189e-05	3.378	16 ACVR1, ANGPTL4, COL15A1, EDN1, ERAP1, FGF1, FGF2, HHEX, HMOX1, IL6, IL8, SCG2, SEMA5A, SRF, TNFAIP2, VEGFA	104	angiogenesis
GO:0048646	4.496e-05	4.743	19 ACVR1, ANGPTL4, BMPR2, COL15A1, EDN1, EGR2, ERAP1, FGF1, FGF2, HHEX, HMOX1, IL6, IL8, NR4A3, SCG2, SEMA5A, SRF, TNFAIP2, VEGFA	146	anatomical structure formation
GO:0008283	5.172e-05	18.35	42 ADRA2A, BMPR2, CCL2, CREG1, CSF1, EDN1, FGF1, FGF2, FGF5, FGF7, FURIN, GPNMB, HBEGF, HHEX, HMOX1, HTR2A, IGFBP5, IGFBP7, IL11, IL23A, IL6, IL6ST, IL8, JARID2, LIF, NAMPT, NP, PDGFA, PDGFD, PPAP2A, PPARD, SCG2, SOX4, TBX3, TGM2, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA, VEGFB, ZEB1	565	cell proliferation
GO:0009653	5.274e-05	22.51	48 ACVR1, ANGPTL4, BMPR2, CCL2, CDC42SE1, COL15A1, CORIN, CST3, DCN, DGKD, EDN1, EGR2, ERAP1, FGF1, FGF2, GAA, GAP43, HHEX, HMOX1, HOXB5, HOXB6, HOXB7, HTRA1, IDUA, IGFBP5, IGFBP7, IL6, IL8, JARID2, MAP1S, MTSS1, NINJ1, NR4A3, NRXN3, SCG2, SCML2, SEMA5A, SFRP1, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TPD52, VDR, VEGFA, VEGFB	693	anatomical structure morphogenesis
GO:0050900	5.722e-05	0.9745	9 CCL2, EDN1, HMOX1, ICAM1, IL6, IL8, ITGA1, SCG2, VEGFA	30	leukocyte migration
GO:0006952	6.779e-05	8.543	26 ACVR1, C1R, C1S, CCL2, CD55, CFHR1, CST3, ERAP1, H2BFS, HIST1H2BK, HLA-B, HMOX1, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, JMJD3, KCNN4, LGALS3BP, LY96, NFKB1, SCG2, TGM2, TPST1	263	defense response
GO:0001568	7.790e-05	4.45	18 ACVR1, ANGPTL4, COL15A1, CST3, EDN1, ERAP1, FGF1, FGF2, HHEX, HMOX1, IL6, IL8, SCG2, SEMA5A, SRF, TGM2, TNFAIP2, VEGFA	137	blood vessel development
GO:0001944	9.506e-05	4.515	18 ACVR1, ANGPTL4, COL15A1, CST3, EDN1, ERAP1, FGF1, FGF2, HHEX, HMOX1, IL6, IL8, SCG2, SEMA5A, SRF, TGM2, TNFAIP2, VEGFA	139	vasculature development
GO:0016477	1.131e-04	5.555	20 ACVR1, CCL2, CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, PDGFA, PPAP2A, PPARD, SCG2, SRF, TNS3, TRIB1, VEGFA	171	cell migration
GO:0048870	1.866e-04	5.75	20 ACVR1, CCL2, CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, PDGFA, PPAP2A, PPARD, SCG2, SRF, TNS3, TRIB1, VEGFA	177	cell motility
GO:0042060	2.608e-04	2.599	13 EDN1, F10, F3, GAP43, HBEGF, HMOX1, IL6, NINJ1, PDGFA, PLAUR, PPARD, PROS1, SRF	80	wound healing
GO:0048522	2.907e-04	26.21	51 ABLIM3, ACVR1, ADRA2A, BMPR2, CASP1, CASP4, CBFB, CCL2, CSF1, ECM1, EDN1, EGR2, FAS, FGF1, FGF2, FGF7, FURIN, GRIK2, HBEGF, HHEX, HMOX1, HTR2A, HTR2B, ICAM1, IL11, IL6, IL6ST, JUND, LIF, LITAF, MAP3K7IP2, NAMPT, NFKB1, NP, NR4A3, PDGFA, PPARD, RUNX1, SCG2, SOX4, SRF, TBX3, TGM2, TM2D1, TNFSF4, TNS3, TP53BP2, TRAF3, VEGFA, VEGFB, WWTR1	807	positive regulation of cellular process
GO:0044057	2.963e-04	2.631	13 BHLHE40, BMPR2, DES, EDN1, EGR2, GAA, GRIK2, HBEGF, HMOX1, HSPB7, HTR2A, IL6ST, SRF	81	regulation of system process
GO:0001649	3.349e-04	0.9095	8 ACVR1, BMPR2, CBFB, GPNMB, IL6, IL6ST, JUND, WWTR1	28	osteoblast differentiation
GO:0048583	3.387e-04	3.995	16 C1R, C1S, CD55, CFHR1, EDN1, ERAP1, HMOX1, ICAM1, IL6, IL6ST, IL8, NPC1, PDGFA, SCG2, TGM2, VEGFA	123	regulation of response to stimulus
GO:0006954	3.401e-04	4.97	18 ACVR1, C1R, C1S, CCL2, CD55, CFHR1, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, LY96, NFKB1, SCG2, TGM2, TPST1	153	inflammatory response
GO:0040012	3.814e-04	2.696	13 CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, PDGFA, SCG2, TRIB1, VEGFA	83	regulation of locomotion
GO:0045597	4.853e-04	2.761	13 ACVR1, BMPR2, CSF1, FGF2, IL6, IL6ST, JUND, LIF, NFKB1, NP, PPARD, RUNX1, SRF	85	positive regulation of cell differentiation
GO:0048869	5.015e-04	26.77	51 ACVR1, ANGPTL4, BMPR2, CBFB, CDC42SE1, COL15A1, CSF1, DGKD, DNASE2, EDN1, EGR2, ERAP1, FAS, FGF1, FGF2, FGF5, GAP43, GNPTAB, GPNMB, HHEX, HLX, HOXB5, HOXB7, HTRA1, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, JUND, LIF, MAP1S, MTSS1, NFKB1, NP, NRXN3, OSTM1, PPARD, RUNX1, SEMA5A, SFRP1, SOX4, SPRY2, SRF, TBX3, TNFAIP2, TPD52, VEGFA, VEGFB, WWTR1	824	cellular developmental process
GO:0001501	6.537e-04	5.23	18 ACVR1, BMPR2, CBFB, EDN1, EGR2, GPNMB, HEXA, HOXB5, HOXB6, HOXB7, IDUA, IL6, IL6ST, JUND, TBX3, TNFRSF11B, VDR, WWTR1	161	skeletal system development
GO:0040011	6.547e-04	7.406	22 ACVR1, CCL2, CCRL1, CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, PDGFA, PLAUR, PPAP2A, PPARD, SCG2, SRF, TNS3, TRIB1, VEGFA	228	locomotion
GO:0010646	7.385e-04	13.64	32 ACVR1, BHLHE40, CASP1, DKK2, ECM1, EDN1, EGR2, GRIK2, HHEX, HMOX1, HTR2A, HTR2B, HTRA1, IGFBP5, IL11, IL1RL1, IL6, IL6ST, LIF, LITAF, MAP3K7IP2, NPC1, PPARD, RAPGEF2, RGS2, SOX4, SPRED2, SPRY2, SPRY4, TGM2, TRIB1, VEGFA	420	regulation of cell communication
GO:0050793	7.421e-04	22.71	45 ACVR1, ANGPTL4, BMPR2, CASP1, CASP4, CCL2, CDC42SE1, CSF1, CST3, DGKD, EDN1, EGR2, ERAP1, FAS, FGF2, FURIN, GRIK2, HHEX, HIPK3, HMOX1, HTRA1, IGFBP5, IGFBP7, IL6, IL6ST, JUND, LIF, NFKB1, NP, PPARD, RUNX1, SCG2, SERPINB2, SFRP1, SOX4, SRF, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA, VEGFB, WWTR1	699	regulation of developmental process
GO:0007610	9.559e-04	5.392	18 CCL2, CCRL1, EDN1, EGR2, FGF2, FOSB, GAA, HEXA, HTR2A, IL6, IL8, ITGA1, MAN2B1, NR4A3, PDGFA, PLAUR, SCG2, VEGFA	166	behavior
GO:0048771	1.075e-03	1.754	10 ACVR1, BMPR2, CST3, EGR2, IL23A, IL6, IL6ST, JUND, TGM2, TPP1	54	tissue remodeling
GO:0002474	1.415e-03	0.5522	6 ERAP1, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	17	antigen processing and presentation of peptide antigen via MHC class I
GO:0030595	1.415e-03	0.5522	6 CCL2, EDN1, IL6, IL8, ITGA1, SCG2	17	leukocyte chemotaxis
GO:0060326	1.415e-03	0.5522	6 CCL2, EDN1, IL6, IL8, ITGA1, SCG2	17	cell chemotaxis
GO:0030154	1.433e-03	21.89	43 ACVR1, ANGPTL4, BMPR2, CBFB, COL15A1, CSF1, DNASE2, EDN1, EGR2, ERAP1, FAS, FGF1, FGF2, FGF5, GAP43, GNPTAB, GPNMB, HHEX, HLX, HOXB5, HOXB7, IL11, IL6, IL6ST, JUND, LIF, MAP1S, NFKB1, NP, NRXN3, OSTM1, PPARD, RUNX1, SEMA5A, SFRP1, SOX4, SPRY2, SRF, TBX3, TNFAIP2, TPD52, VEGFA, WWTR1	674	cell differentiation
GO:0006935	1.597e-03	2.241	11 CCL2, CCRL1, EDN1, FGF2, IL6, IL8, ITGA1, PDGFA, PLAUR, SCG2, VEGFA	69	chemotaxis
GO:0042330	1.597e-03	2.241	11 CCL2, CCRL1, EDN1, FGF2, IL6, IL8, ITGA1, PDGFA, PLAUR, SCG2, VEGFA	69	taxis
GO:0048523	1.897e-03	28.23	51 ACVR1, ANGPTL4, ARID5A, BCL7A, BHLHE40, CCL2, CST3, DKK2, DNAJC1, EDN1, FAS, FGF2, FOSB, FURIN, GPNMB, HHEX, HIPK3, HMOX1, HTR2A, HTRA1, IGFBP5, IGFBP7, IL11, IL1RL1, IL6, IL6ST, IL8, JARID2, JMJD3, LIF, LMCD1, MAF, MTSS1, NAB1, NFKB1, NPC1, PDGFA, PPAP2A, RGS2, SCG2, SERPINB2, SFRP1, SOX4, TBX3, TP53BP2, TP53I11, TRIB1, VDR, VEGFA, WWTR1, ZEB1	869	negative regulation of cellular process
GO:0048519	2.125e-03	29.92	53 ACVR1, ANGPTL4, ARID5A, BCL7A, BHLHE40, BMPR2, CCL2, CST3, DKK2, DNAJC1, EDN1, FAS, FGF2, FOSB, FURIN, GPNMB, HHEX, HIPK3, HMOX1, HTR2A, HTRA1, IGFBP5, IGFBP7, IL11, IL1RL1, IL6, IL6ST, IL8, JARID2, JMJD3, LIF, LMCD1, MAF, MTSS1, NAB1, NFKB1, NPC1, PDGFA, PPAP2A, RGS2, SCG2, SERPINB2, SFRP1, SOX4, TBX3, TNFRSF11B, TP53BP2, TP53I11, TRIB1, VDR, VEGFA, WWTR1, ZEB1	921	negative regulation of biological process
GO:0007626	2.598e-03	3.281	13 CCL2, CCRL1, EDN1, FGF2, GAA, HEXA, IL6, IL8, ITGA1, PDGFA, PLAUR, SCG2, VEGFA	101	locomotory behavior
GO:0006950	2.670e-03	27.87	50 ACVR1, ADRA2A, ANGPTL4, C1R, C1S, CCL2, CD55, CFHR1, CST3, DPP4, EDN1, ERAP1, F10, F3, FGF7, GAP43, GPX3, H2BFS, HBEGF, HIST1H2BK, HLA-B, HMOX1, HSPB7, HTR2A, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, JMJD3, KCNN4, LGALS3BP, LY96, MAP3K4, NFKB1, NINJ1, NPC1, PDGFA, PLAUR, PPARD, PROS1, SCG2, SETX, SRF, TGM2, TP53I11, TPST1, TRIB1, VEGFA	858	response to stress
GO:0002682	2.946e-03	4.84	16 C1R, C1S, CD55, CFHR1, CSF1, ERAP1, FAS, HMOX1, ICAM1, IL6, IL6ST, LIF, NFKB1, NP, RUNX1, VEGFA	149	regulation of immune system process
GO:0065008	3.042e-03	21.21	41 BMPR2, CCL2, CD55, CDC42SE1, CORIN, DGKD, DNASE2, EDN1, EGR2, ERAP1, F10, F3, FAS, FURIN, GAA, HEXA, HMOX1, HOXB6, HTR2A, HTRA1, IDUA, IGFBP5, IGFBP7, IL11, IL6, ITPR3, KCNN4, LIF, NPC1, NPC2, NR3C1, PDGFA, PLAUR, PROS1, SRF, TBX3, TGM2, TPP1, VDR, VEGFA, VEGFB	653	regulation of biological quality
GO:0030334	3.171e-03	2.436	11 CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, PDGFA, TRIB1, VEGFA	75	regulation of cell migration
GO:0030335	3.379e-03	1.267	8 CSF1, EDN1, FGF2, HBEGF, ICAM1, IL6, PDGFA, VEGFA	39	positive regulation of cell migration
GO:0001775	3.625e-03	4.938	16 CBFB, CSF1, DPP4, EDN1, FAS, HMOX1, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, NP, PDGFA, SOX4, TPD52	152	cell activation
GO:0051094	3.672e-03	9.648	24 ACVR1, ANGPTL4, BMPR2, CASP4, CSF1, ERAP1, FAS, FGF2, GRIK2, HMOX1, IL6, IL6ST, JUND, LIF, NFKB1, NP, PPARD, RUNX1, SOX4, SRF, TGM2, TM2D1, TP53BP2, TRAF3	297	positive regulation of developmental process
GO:0019882	3.979e-03	1.299	8 ERAP1, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, ICAM1, PSMB8	40	antigen processing and presentation
GO:0045321	3.984e-03	4.45	15 CBFB, CSF1, DPP4, EDN1, FAS, HMOX1, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, NP, SOX4, TPD52	137	leukocyte activation
GO:0032101	4.285e-03	1.689	9 EDN1, IL6, IL6ST, IL8, NPC1, PDGFA, SCG2, TGM2, VEGFA	52	regulation of response to external stimulus
GO:0048002	4.478e-03	0.6822	6 ERAP1, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	21	antigen processing and presentation of peptide antigen
GO:0048660	4.478e-03	0.6822	6 EDN1, HBEGF, IGFBP5, IL6, TGM2, TRIB1	21	regulation of smooth muscle cell proliferation
GO:0033002	5.154e-03	1.007	7 EDN1, FGF2, HBEGF, IGFBP5, IL6, TGM2, TRIB1	31	muscle cell proliferation
GO:0048659	5.684e-03	0.7146	6 EDN1, HBEGF, IGFBP5, IL6, TGM2, TRIB1	22	smooth muscle cell proliferation
GO:0045669	5.818e-03	0.4548	5 ACVR1, BMPR2, IL6, IL6ST, JUND	14	positive regulation of osteoblast differentiation
GO:0007243	6.429e-03	9.42	23 ADRA2A, CASP1, CCL2, ECM1, EDN1, FGF2, HMOX1, HTR2B, IL11, IL1RL1, IL6, IL6ST, LIF, LITAF, LY96, MAP3K4, MAP3K7IP2, PPARD, RAPGEF2, SCG2, STK38L, TGM2, TRIB1	290	protein kinase cascade
GO:0048584	6.961e-03	2.241	10 C1R, C1S, CD55, CFHR1, IL6, IL6ST, IL8, SCG2, TGM2, VEGFA	69	positive regulation of response to stimulus
GO:0051272	7.174e-03	1.429	8 CSF1, EDN1, FGF2, HBEGF, ICAM1, IL6, PDGFA, VEGFA	44	positive regulation of cell motion
GO:0010740	7.204e-03	3.183	12 CASP1, ECM1, HMOX1, HTR2B, IL11, IL6, IL6ST, LIF, LITAF, MAP3K7IP2, PPARD, TGM2	98	positive regulation of protein kinase cascade
GO:0009966	8.105e-03	12.25	27 ACVR1, CASP1, DKK2, ECM1, EDN1, HHEX, HMOX1, HTR2B, HTRA1, IGFBP5, IL11, IL1RL1, IL6, IL6ST, LIF, LITAF, MAP3K7IP2, PPARD, RAPGEF2, RGS2, SOX4, SPRED2, SPRY2, SPRY4, TGM2, TRIB1, VEGFA	377	regulation of signal transduction
GO:0045595	8.418e-03	5.944	17 ACVR1, BMPR2, CSF1, EDN1, FAS, FGF2, IL6, IL6ST, JUND, LIF, NFKB1, NP, PPARD, RUNX1, SRF, TBX3, WWTR1	183	regulation of cell differentiation
GO:0051240	8.493e-03	2.306	10 ACVR1, BMPR2, EDN1, FGF2, GRIK2, HMOX1, HTR2A, IL6, IL6ST, SRF	71	positive regulation of multicellular organismal process
GO:0032103	8.723e-03	0.7796	6 IL6, IL6ST, IL8, SCG2, TGM2, VEGFA	24	positive regulation of response to external stimulus
GO:0010647	8.796e-03	4.84	15 CASP1, ECM1, GRIK2, HMOX1, HTR2B, IL11, IL6, IL6ST, LIF, LITAF, MAP3K7IP2, PPARD, SOX4, TGM2, VEGFA	149	positive regulation of cell communication
GO:0007389	9.115e-03	3.281	12 ACVR1, BMPR2, EDN1, EGR2, FGF1, FGF2, HOXB5, HOXB6, HOXB7, SEMA5A, SFRP1, TBX3	101	pattern specification process
GO:0051241	9.309e-03	1.494	8 BMPR2, CST3, EDN1, FURIN, HMOX1, HTR2A, IL6, PDGFA	46	negative regulation of multicellular organismal process
GO:0010627	1.002e-02	3.833	13 CASP1, ECM1, HMOX1, HTR2B, IL11, IL1RL1, IL6, IL6ST, LIF, LITAF, MAP3K7IP2, PPARD, TGM2	118	regulation of protein kinase cascade
GO:0007166	1.051e-02	22.67	41 ACVR1, ADRA2A, BMPR2, CBLB, CCL2, CCRL1, CPZ, DGKD, DKK2, EDN1, FGF1, FGF2, FGF5, FGF7, GAP43, GEM, GPR183, GPR37, GRIK2, HBEGF, HHEX, HTR2A, HTR2B, HTRA1, IGFBP5, IL6, IL6ST, IL8, ITGA1, ITPR3, LIF, LY96, MTSS1, PDGFA, PPAP2A, RGS2, SFRP1, SOX4, TGM2, TRIB1, VEGFA	698	cell surface receptor linked signal transduction
GO:0002685	1.086e-02	0.2924	4 HMOX1, ICAM1, IL6, VEGFA	9	regulation of leukocyte migration
GO:0003002	1.119e-02	2.404	10 BMPR2, EDN1, EGR2, FGF1, FGF2, HOXB5, HOXB6, HOXB7, SFRP1, TBX3	74	regionalization
GO:0033135	1.166e-02	0.1299	3 IL11, IL6, LIF	4	regulation of peptidyl-serine phosphorylation
GO:0033138	1.166e-02	0.1299	3 IL11, IL6, LIF	4	positive regulation of peptidyl-serine phosphorylation
GO:0050930	1.166e-02	0.1299	3 IL8, SCG2, VEGFA	4	induction of positive chemotaxis
GO:0051270	1.257e-02	2.924	11 CSF1, EDN1, FGF2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, PDGFA, TRIB1, VEGFA	90	regulation of cell motion
GO:0051260	1.267e-02	0.8446	6 DGKD, FAS, GPX3, ITPR3, STOM, TGM2	26	protein homooligomerization
GO:0002526	1.327e-02	1.202	7 ACVR1, C1R, C1S, CD55, CFHR1, IL6, IL6ST	37	acute inflammatory response
GO:0065007	1.330e-02	122.4	150 ABLIM3, ACVR1, ADRA2A, ANGPTL4, ARID5A, BCL7A, BHLHE40, BMPR2, C1R, C1S, CASP1, CASP4, CBFB, CBLB, CCL2, CCRL1, CD55, CDC42SE1, CFHR1, CORIN, CPZ, CREG1, CSF1, CST3, DES, DGKD, DKK2, DNAJC1, DNASE2, DPP4, ECM1, EDN1, EGR2, EGR3, ERAP1, F10, F3, FAS, FGF1, FGF2, FGF5, FGF7, FOSB, FURIN, GAA, GAP43, GEM, GPNMB, GPR183, GPR37, GRIK2, GRN, HBEGF, HEXA, HHEX, HIPK3, HLX, HMOX1, HOXB5, HOXB6, HOXB7, HSPB7, HTR2A, HTR2B, HTRA1, ICAM1, IDUA, IGFBP5, IGFBP7, IL11, IL1RAP, IL1RL1, IL6, IL6ST, IL8, INPP1, ITGA1, ITPR3, JARID2, JMJD3, JUND, KCNN4, KHDRBS3, LBH, LGALS3BP, LIF, LITAF, LMCD1, LY96, MAF, MAP3K4, MAP3K7IP2, MEIS1, MEIS3P1, MFAP4, MTSS1, NAB1, NAMPT, NFATC1, NFIL3, NFKB1, NP, NPC1, NPC2, NR3C1, NR4A3, PDGFA, PDGFD, PIK3CD, PLAUR, PMEPA1, PPAP2A, PPARD, PROS1, PSMB8, RAPGEF2, RCAN2, RGS2, RRAD, RUNX1, SCG2, SCML2, SERPINB2, SFRP1, SOX4, SPRED2, SPRY2, SPRY4, SRF, STK38L, TBX3, TEX2, TGM2, TM2D1, TNFRSF11B, TNFSF4, TNS3, TP53BP2, TP53I11, TPP1, TRAF3, TRIB1, TRIM22, VDR, VEGFA, VEGFB, WWTR1, ZEB1, ZNF282, ZNF35	3768	biological regulation
GO:0003013	1.357e-02	2.956	11 BMPR2, CORIN, DES, EDN1, ERAP1, GAA, HBEGF, HMOX1, HSPB7, HTR2A, HTR2B	91	circulatory system process
GO:0008015	1.357e-02	2.956	11 BMPR2, CORIN, DES, EDN1, ERAP1, GAA, HBEGF, HMOX1, HSPB7, HTR2A, HTR2B	91	blood circulation
GO:0009967	1.410e-02	4.548	14 CASP1, ECM1, HMOX1, HTR2B, IL11, IL6, IL6ST, LIF, LITAF, MAP3K7IP2, PPARD, SOX4, TGM2, VEGFA	140	positive regulation of signal transduction
GO:0034103	1.517e-02	1.234	7 ACVR1, BMPR2, CST3, EGR2, IL6, IL6ST, JUND	38	regulation of tissue remodeling
GO:0007040	1.663e-02	0.5847	5 GAA, HEXA, IDUA, PSAP, TPP1	18	lysosome organization
GO:0045667	1.663e-02	0.5847	5 ACVR1, BMPR2, IL6, IL6ST, JUND	18	regulation of osteoblast differentiation
GO:0046849	1.722e-02	1.267	7 ACVR1, BMPR2, EGR2, IL6, IL6ST, JUND, TPP1	39	bone remodeling
GO:0007154	1.722e-02	63.25	88 ACVR1, ADRA2A, ANGPTL4, BHLHE40, BMPR2, CASP1, CBLB, CCL2, CCRL1, CDC42SE1, CPZ, DGKD, DKK2, ECM1, EDN1, EGR2, EGR3, FAS, FGF1, FGF2, FGF5, FGF7, GAP43, GEM, GPR183, GPR37, GRIK2, GRN, HBEGF, HEXA, HHEX, HMOX1, HTR2A, HTR2B, HTRA1, IGFBP5, IL11, IL1RAP, IL1RL1, IL6, IL6ST, IL8, INPP1, ITGA1, ITPR3, LGALS3BP, LIF, LITAF, LY96, MAP3K4, MAP3K7IP2, MFAP4, MTSS1, NAMPT, NFATC1, NFKB1, NPC1, NR3C1, PDGFA, PIK3CD, PLAUR, PMEPA1, PPAP2A, PPARD, RAPGEF2, RCAN2, RGS2, RRAD, SCG2, SEMA5A, SFRP1, SLC1A1, SOX4, SPRED2, SPRY2, SPRY4, STK38L, TBX3, TEX2, TGM2, TNFRSF11B, TNFSF4, TP53BP2, TRAF3, TRIB1, VDR, VEGFA, VEGFB	1947	cell communication
GO:0002521	1.956e-02	3.118	11 CBFB, CSF1, FAS, IL11, LIF, NFKB1, NP, OSTM1, RUNX1, SOX4, TPD52	96	leukocyte differentiation
GO:0001503	2.101e-02	2.176	9 ACVR1, BMPR2, CBFB, EGR2, GPNMB, IL6, IL6ST, JUND, WWTR1	67	ossification
GO:0060348	2.101e-02	2.176	9 ACVR1, BMPR2, CBFB, EGR2, GPNMB, IL6, IL6ST, JUND, WWTR1	67	bone development
GO:0048010	2.174e-02	0.3573	4 BMPR2, CCL2, HHEX, VEGFA	11	vascular endothelial growth factor receptor signaling pathway
GO:0031330	2.293e-02	0.1624	3 CST3, FURIN, NPC1	5	negative regulation of cellular catabolic process
GO:0006959	2.384e-02	0.9745	6 C1R, C1S, CCL2, CD55, CFHR1, IL6	30	humoral immune response
GO:0007169	2.428e-02	4.873	14 BMPR2, CCL2, DGKD, FGF1, FGF2, FGF5, FGF7, HBEGF, HHEX, IGFBP5, MTSS1, PDGFA, RGS2, VEGFA	150	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0003008	2.462e-02	14.81	29 BHLHE40, BMPR2, CORIN, DES, EDN1, EGR2, EGR3, ERAP1, FAS, GAA, GRIK2, HBEGF, HEXA, HMOX1, HSPB7, HTR2A, HTR2B, IL6ST, ITPR3, KCNN4, MAN2B1, NR4A3, SLC19A2, SLC1A1, SPRY2, SRF, STBD1, TPP1, VDR	456	system process
GO:0007033	2.490e-02	0.6497	5 GAA, HEXA, IDUA, PSAP, TPP1	20	vacuole organization
GO:0048534	2.690e-02	4.938	14 CBFB, CSF1, DNASE2, FAS, HOXB7, IL11, JARID2, LIF, NFKB1, NP, OSTM1, RUNX1, SOX4, TPD52	152	hemopoietic or lymphoid organ development
GO:0007267	2.703e-02	8.673	20 BHLHE40, EDN1, EGR2, EGR3, FGF1, FGF2, FGF5, GRIK2, HEXA, HTR2A, IL11, IL6, IL8, LIF, NAMPT, PDGFA, SEMA5A, SLC1A1, SPRY2, TBX3	267	cell-cell signaling
GO:0051046	2.965e-02	1.852	8 DNAJC1, EDN1, HMOX1, HTR2A, IL11, IL6, KCNN4, LIF	57	regulation of secretion
GO:0018209	2.969e-02	0.6822	5 GALNT3, HIPK3, IL11, IL6, LIF	21	peptidyl-serine modification
GO:0018212	3.050e-02	1.429	7 IL11, IL6, IL6ST, LIF, PDGFD, TPST1, TPST2	44	peptidyl-tyrosine modification
GO:0010648	3.061e-02	2.826	10 ACVR1, DKK2, HHEX, HTR2A, HTRA1, IGFBP5, IL1RL1, NPC1, RGS2, TRIB1	87	negative regulation of cell communication
GO:0030278	3.105e-02	1.039	6 ACVR1, BMPR2, EGR2, IL6, IL6ST, JUND	32	regulation of ossification
GO:0045765	3.105e-02	1.039	6 ANGPTL4, ERAP1, FGF2, HHEX, HMOX1, IL6	32	regulation of angiogenesis
GO:0007167	3.217e-02	7.536	18 ACVR1, BMPR2, CCL2, DGKD, FGF1, FGF2, FGF5, FGF7, HBEGF, HHEX, HTRA1, IGFBP5, IL6ST, LIF, MTSS1, PDGFA, RGS2, VEGFA	232	enzyme linked receptor protein signaling pathway
GO:0032879	3.295e-02	6.919	17 CSF1, DNAJC1, EDN1, FGF2, HBEGF, HMOX1, HTR2A, ICAM1, IGFBP5, IL11, IL6, KCNN4, LIF, NFKB1, PDGFA, TRIB1, VEGFA	213	regulation of localization
GO:0030099	3.474e-02	2.891	10 CBFB, CSF1, DNASE2, FAS, HOXB7, IL11, LIF, NFKB1, OSTM1, RUNX1	89	myeloid cell differentiation
GO:0043542	3.482e-02	0.7146	5 EDN1, FGF2, SCG2, SRF, VEGFA	22	endothelial cell migration
GO:0050776	3.599e-02	2.404	9 C1R, C1S, CD55, CFHR1, ERAP1, HMOX1, ICAM1, IL6, IL6ST	74	regulation of immune response
GO:0002763	3.633e-02	0.4223	4 CSF1, LIF, NFKB1, RUNX1	13	positive regulation of myeloid leukocyte differentiation
GO:0040017	3.633e-02	0.4223	4 IL6, IL8, SCG2, VEGFA	13	positive regulation of locomotion
GO:0048520	3.633e-02	0.4223	4 IL6, IL8, SCG2, VEGFA	13	positive regulation of behavior
GO:0050920	3.633e-02	0.4223	4 IL6, IL8, SCG2, VEGFA	13	regulation of chemotaxis
GO:0050921	3.633e-02	0.4223	4 IL6, IL8, SCG2, VEGFA	13	positive regulation of chemotaxis
GO:0010595	3.687e-02	0.1949	3 EDN1, FGF2, VEGFA	6	positive regulation of endothelial cell migration
GO:0014910	3.687e-02	0.1949	3 IGFBP5, PDGFA, TRIB1	6	regulation of smooth muscle cell migration
GO:0050918	3.687e-02	0.1949	3 IL8, SCG2, VEGFA	6	positive chemotaxis
GO:0050926	3.687e-02	0.1949	3 IL8, SCG2, VEGFA	6	regulation of positive chemotaxis
GO:0050927	3.687e-02	0.1949	3 IL8, SCG2, VEGFA	6	positive regulation of positive chemotaxis
GO:0050878	3.780e-02	1.949	8 EDN1, F10, F3, IL6, KCNN4, PDGFA, PLAUR, PROS1	60	regulation of body fluid levels
GO:0035295	3.844e-02	2.436	9 ACVR1, BMPR2, EDN1, FGF1, FGF2, HHEX, SEMA5A, SPRY2, TNS3	75	tube development
GO:0030097	4.261e-02	4.678	13 CBFB, CSF1, DNASE2, FAS, HOXB7, IL11, LIF, NFKB1, NP, OSTM1, RUNX1, SOX4, TPD52	144	hemopoiesis
GO:0046850	4.380e-02	1.137	6 ACVR1, BMPR2, EGR2, IL6, IL6ST, JUND	35	regulation of bone remodeling
GO:0007205	4.445e-02	0.4548	4 DGKD, EDN1, GAP43, PPAP2A	14	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0048661	4.445e-02	0.4548	4 EDN1, HBEGF, IL6, TGM2	14	positive regulation of smooth muscle cell proliferation
GO:0050795	4.445e-02	0.4548	4 IL6, IL8, SCG2, VEGFA	14	regulation of behavior
GO:0050885	4.445e-02	0.4548	4 GAA, HEXA, NR4A3, TPP1	14	neuromuscular process controlling balance
GO:0007165	4.602e-02	58.47	80 ACVR1, ADRA2A, ANGPTL4, BMPR2, CASP1, CBLB, CCL2, CCRL1, CDC42SE1, CPZ, DGKD, DKK2, ECM1, EDN1, FAS, FGF1, FGF2, FGF5, FGF7, GAP43, GEM, GPR183, GPR37, GRIK2, GRN, HBEGF, HHEX, HMOX1, HTR2A, HTR2B, HTRA1, IGFBP5, IL11, IL1RAP, IL1RL1, IL6, IL6ST, IL8, INPP1, ITGA1, ITPR3, LGALS3BP, LIF, LITAF, LY96, MAP3K4, MAP3K7IP2, MFAP4, MTSS1, NAMPT, NFATC1, NFKB1, NR3C1, PDGFA, PIK3CD, PLAUR, PMEPA1, PPAP2A, PPARD, RAPGEF2, RCAN2, RGS2, RRAD, SCG2, SFRP1, SOX4, SPRED2, SPRY2, SPRY4, STK38L, TEX2, TGM2, TNFRSF11B, TNFSF4, TP53BP2, TRAF3, TRIB1, VDR, VEGFA, VEGFB	1800	signal transduction
GO:0043066	4.633e-02	6.594	16 ACVR1, ANGPTL4, CCL2, FAS, FURIN, HIPK3, HMOX1, IL6, IL6ST, NFKB1, SCG2, SERPINB2, SFRP1, SOX4, TBX3, VEGFA	203	negative regulation of apoptosis
GO:0019932	4.634e-02	3.053	10 CCL2, DGKD, EDN1, HTR2A, HTR2B, IL8, PIK3CD, RAPGEF2, RCAN2, TGM2	94	second-messenger-mediated signaling
GO:0002520	4.863e-02	5.392	14 CBFB, CSF1, DNASE2, FAS, HOXB7, IL11, JARID2, LIF, NFKB1, NP, OSTM1, RUNX1, SOX4, TPD52	166	immune system development
GO:0044262	4.863e-02	5.392	14 CSGALNACT2, GAA, GNS, HEXA, HK2, IDS, IDUA, IL6ST, MAN2B1, MAN2B2, NR3C1, PPARD, SGSH, SULF1	166	cellular carbohydrate metabolic process
GO:0050789	4.898e-02	116.1	140 ABLIM3, ACVR1, ADRA2A, ANGPTL4, ARID5A, BCL7A, BHLHE40, BMPR2, C1R, C1S, CASP1, CASP4, CBFB, CBLB, CCL2, CCRL1, CD55, CDC42SE1, CFHR1, CPZ, CREG1, CSF1, CST3, DES, DGKD, DKK2, DNAJC1, DPP4, ECM1, EDN1, EGR2, EGR3, ERAP1, FAS, FGF1, FGF2, FGF5, FGF7, FOSB, FURIN, GAA, GAP43, GEM, GPNMB, GPR183, GPR37, GRIK2, GRN, HBEGF, HHEX, HIPK3, HLX, HMOX1, HOXB5, HOXB7, HSPB7, HTR2A, HTR2B, HTRA1, ICAM1, IGFBP5, IGFBP7, IL11, IL1RAP, IL1RL1, IL6, IL6ST, IL8, INPP1, ITGA1, ITPR3, JARID2, JMJD3, JUND, KCNN4, KHDRBS3, LBH, LGALS3BP, LIF, LITAF, LMCD1, LY96, MAF, MAP3K4, MAP3K7IP2, MEIS1, MEIS3P1, MFAP4, MTSS1, NAB1, NAMPT, NFATC1, NFIL3, NFKB1, NP, NPC1, NPC2, NR3C1, NR4A3, PDGFA, PDGFD, PIK3CD, PLAUR, PMEPA1, PPAP2A, PPARD, RAPGEF2, RCAN2, RGS2, RRAD, RUNX1, SCG2, SCML2, SERPINB2, SFRP1, SOX4, SPRED2, SPRY2, SPRY4, SRF, STK38L, TBX3, TEX2, TGM2, TM2D1, TNFRSF11B, TNFSF4, TNS3, TP53BP2, TP53I11, TRAF3, TRIB1, TRIM22, VDR, VEGFA, VEGFB, WWTR1, ZEB1, ZNF282, ZNF35	3574	regulation of biological process
GO:0046903	4.982e-02	4.808	13 CADPS2, DNAJC1, EDN1, FURIN, HMOX1, HTR2A, IL11, IL6, KCNN4, LIF, SCG2, TBX3, TPD52	148	secretion

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005576	3.428e-14	21.72	65 ANGPTL4, C1R, C1S, CCL2, CFHR1, COL15A1, CPZ, CREG1, CSF1, CST3, DCN, DKK2, DPP4, ECM1, EDN1, ERAP1, F10, FAS, FGF1, FGF2, FGF5, FGF7, FURIN, GPX3, GRN, HBEGF, HLA-C, HMOX1, HTRA1, ICAM1, IGFBP5, IGFBP7, IL11, IL1RAP, IL1RL1, IL23A, IL6, IL6ST, IL8, LGALS3BP, LIF, LY96, MAN2B2, MFAP4, NID1, NPC2, OLFML2A, PDGFA, PDGFD, PLAUR, PROS1, PSAP, PTGDS, RNASET2, SCG2, SERPINB2, SFRP1, SULF1, SVEP1, TCTN1, TNFAIP2, TNFRSF11B, TNFSF4, VEGFA, VEGFB	700	extracellular region
GO:0005615	4.428e-10	7.633	32 ANGPTL4, CCL2, CFHR1, CSF1, CST3, DKK2, EDN1, FGF1, FGF2, FGF5, FURIN, GPX3, GRN, HBEGF, HMOX1, HTRA1, ICAM1, IGFBP5, IL11, IL23A, IL6, IL8, LGALS3BP, LIF, PDGFA, PSAP, SCG2, SFRP1, SULF1, TNFAIP2, TNFSF4, VEGFA	246	extracellular space
GO:0044421	1.219e-09	12.01	40 ANGPTL4, CCL2, CFHR1, COL15A1, CPZ, CSF1, CST3, DCN, DKK2, ECM1, EDN1, FGF1, FGF2, FGF5, FURIN, GPX3, GRN, HBEGF, HMOX1, HTRA1, ICAM1, IGFBP5, IL11, IL23A, IL6, IL8, LGALS3BP, LIF, MFAP4, NID1, OLFML2A, PDGFA, PSAP, SCG2, SFRP1, SULF1, TNFAIP2, TNFRSF11B, TNFSF4, VEGFA	387	extracellular region part
GO:0000323	3.819e-06	3.475	17 CTSA, DNASE2, DRAM, GAA, GNS, HEXA, IDS, IDUA, LITAF, MAN2B1, MANBA, NPC1, NPC2, PSAP, SCARB2, SGSH, TPP1	112	lytic vacuole
GO:0005764	3.819e-06	3.475	17 CTSA, DNASE2, DRAM, GAA, GNS, HEXA, IDS, IDUA, LITAF, MAN2B1, MANBA, NPC1, NPC2, PSAP, SCARB2, SGSH, TPP1	112	lysosome
GO:0005773	2.988e-05	4.034	17 CTSA, DNASE2, DRAM, GAA, GNS, HEXA, IDS, IDUA, LITAF, MAN2B1, MANBA, NPC1, NPC2, PSAP, SCARB2, SGSH, TPP1	130	vacuole
GO:0009986	1.853e-03	4.034	14 BMPR2, CORIN, DPP4, FAS, FURIN, HBEGF, ICAM1, IL1RL1, IL6ST, ITGA1, PDGFA, PLAUR, SULF1, VEGFA	130	cell surface
GO:0042612	2.412e-03	0.4654	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	15	MHC class I protein complex
GO:0005887	2.760e-03	17.04	34 ACVR1, ADRA2A, BMPR2, CCRL1, CD55, CLEC2B, CORIN, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HTR2A, HTR2B, ICAM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, NPC1, NRXN3, PPAP2A, RAPGEF2, SCARB2, SLC1A1, SLC20A2, STBD1, STOM, TM2D1, TNFSF4	549	integral to plasma membrane
GO:0031226	3.221e-03	17.19	34 ACVR1, ADRA2A, BMPR2, CCRL1, CD55, CLEC2B, CORIN, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HTR2A, HTR2B, ICAM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, NPC1, NRXN3, PPAP2A, RAPGEF2, SCARB2, SLC1A1, SLC20A2, STBD1, STOM, TM2D1, TNFSF4	554	intrinsic to plasma membrane
GO:0044459	3.646e-03	27.15	47 ACVR1, ADRA2A, AJAP1, BMPR2, CADPS2, CCRL1, CD55, CLEC2B, CORIN, DPP4, FAS, GAP43, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HTR2A, HTR2B, ICAM1, IL1RAP, IL1RL1, IL6, IL6ST, ITGA1, ITPR3, KCNN4, LIMS1, MAGI2, NPC1, NRXN3, PKP2, PPAP2A, RAPGEF2, SCARB2, SLC1A1, SLC20A2, STBD1, STOM, TM2D1, TNFSF4, TNS3	875	plasma membrane part
GO:0005886	1.279e-02	44.78	66 ACVR1, ADRA2A, AJAP1, BMPR2, CADPS2, CCRL1, CD55, CDC42SE1, CHIC2, CLEC2B, CORIN, CSF1, DDX3Y, DES, DGKD, DPP4, F10, F3, FAS, FURIN, GAP43, GEM, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HTR2A, HTR2B, ICAM1, IL1RAP, IL1RL1, IL6, IL6ST, ITGA1, ITPR3, KCNN4, LIMS1, LY96, MAGI2, NPC1, NRXN3, PKP2, PLAUR, PMEPA1, PPAP2A, RAPGEF2, SCARB1, SCARB2, SLC19A2, SLC1A1, SLC20A2, SPRED2, SPRY2, SPRY4, STBD1, STOM, TGM2, TM2D1, TNFSF4, TNS3	1443	plasma membrane
GO:0042611	1.361e-02	0.6826	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	22	MHC protein complex
GO:0016020	4.064e-02	98.27	121 ACBD3, ACVR1, ADRA2A, AJAP1, ANO1, ATP13A3, BMPR2, C19orf28, C9orf167, CADPS2, CCRL1, CD302, CD55, CDC42SE1, CHIC2, CLEC2B, CORIN, CSF1, CSGALNACT2, CYP51A1, DDX3Y, DES, DGKD, DNAJC1, DOCK9, DPP4, DRAM, ERAP1, F10, F3, FADS3, FAS, FURIN, GALNT3, GAP43, GEM, GNPTAB, GPNMB, GPR183, GPR37, GRIK2, HBEGF, HEXA, HK2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HTR2A, HTR2B, ICAM1, IL1RAP, IL1RL1, IL6, IL6ST, ITGA1, ITPR3, KCNN4, KIAA0247, KPNA4, LEPROT, LGALS3BP, LHFP, LIMS1, LITAF, LMBRD1, LRIG1, LY96, MAGI2, MAN1C1, MAP3K7IP2, NID1, NINJ1, NPC1, NR3C1, NRXN3, OLFML2A, OSTM1, PDGFA, PDGFD, PIGB, PKP2, PLAUR, PLSCR4, PMEPA1, PPAP2A, PSAP, PTGDS, RANBP2, RAPGEF2, SCARB1, SCARB2, SEMA5A, SLC10A3, SLC19A2, SLC1A1, SLC20A2, SPRED2, SPRY2, SPRY4, SQLE, SQRDL, STBD1, STOM, SVEP1, TEX2, TGM2, TM2D1, TM6SF1, TMEM39A, TMEM41B, TNFSF4, TNS3, TPST1, TPST2, VEGFA, VEGFB, WTAP, YIPF6, YRDC	3167	membrane

Id	Pvalue	ExpCount	Count	Size	Term
GO:0008083	6.363e-05	2.857	15 CSF1, ERAP1, FGF1, FGF2, FGF5, FGF7, GRN, HBEGF, IL11, IL6, LIF, PDGFA, PDGFD, VEGFA, VEGFB	94	growth factor activity
GO:0005125	1.033e-04	2.219	13 CCL2, CSF1, GRN, IL11, IL23A, IL6, IL8, LIF, NAMPT, SCG2, TNFRSF11B, TNFSF4, VEGFA	73	cytokine activity
GO:0004872	2.016e-04	16.2	38 ACVR1, ADRA2A, BMPR2, CCRL1, CORIN, FAS, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HTR2A, HTR2B, ICAM1, IL1RAP, IL1RL1, IL6ST, ITGA1, ITPR3, LGALS3BP, LY96, NPC1, NR3C1, NR4A3, NRXN3, PLAUR, PPARD, SCARB1, SCARB2, SEMA5A, SLC20A2, TM2D1, TNFRSF11B, VDR	533	receptor activity
GO:0004871	3.115e-04	24.25	49 ACVR1, ADRA2A, BMPR2, CBLB, CCL2, CCRL1, CORIN, ECM1, FAS, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, HTR2A, HTR2B, ICAM1, IL1RAP, IL1RL1, IL6ST, ITGA1, ITPR3, LGALS3BP, LITAF, LY96, MAP3K4, NPC1, NR3C1, NR4A3, NRXN3, PLAUR, PPARD, RAPGEF2, RGS2, SCARB1, SCARB2, SEMA5A, SH3BGRL, SLC20A2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VDR	798	signal transducer activity
GO:0060089	3.115e-04	24.25	49 ACVR1, ADRA2A, BMPR2, CBLB, CCL2, CCRL1, CORIN, ECM1, FAS, GPR183, GPR37, GRIK2, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, HTR2A, HTR2B, ICAM1, IL1RAP, IL1RL1, IL6ST, ITGA1, ITPR3, LGALS3BP, LITAF, LY96, MAP3K4, NPC1, NR3C1, NR4A3, NRXN3, PLAUR, PPARD, RAPGEF2, RGS2, SCARB1, SCARB2, SEMA5A, SH3BGRL, SLC20A2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VDR	798	molecular transducer activity
GO:0032393	7.606e-04	0.2735	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	9	MHC class I receptor activity
GO:0005102	1.247e-03	12.4	30 ANGPTL4, CCL2, CSF1, EDN1, ERAP1, FGF1, FGF2, FGF5, FGF7, GPNMB, GRN, HBEGF, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, LIF, MFAP4, MTSS1, NAMPT, PDGFA, PDGFD, PSMB8, SCG2, TNFRSF11B, TNFSF4, VEGFA, VEGFB	408	receptor binding
GO:0008236	4.290e-03	2.006	10 C1R, C1S, CORIN, CTSA, DPP4, F10, FURIN, HTRA1, SERPINB2, TPP1	66	serine-type peptidase activity
GO:0017171	4.290e-03	2.006	10 C1R, C1S, CORIN, CTSA, DPP4, F10, FURIN, HTRA1, SERPINB2, TPP1	66	serine hydrolase activity
GO:0005509	4.881e-03	12.22	28 ANO1, C1R, C1S, CADPS2, CBLB, EFHD1, F10, FURIN, GALNT3, GNPTAB, GNS, HPCAL1, IDS, ITGA1, ITPR3, MAN1C1, MFAP4, NID1, NRXN3, PLSCR4, PROS1, RAPGEF2, SCG2, SGSH, SULF1, SVEP1, TGM2, TPD52	402	calcium ion binding
GO:0004252	5.491e-03	1.672	9 C1R, C1S, CORIN, DPP4, F10, FURIN, HTRA1, SERPINB2, TPP1	55	serine-type endopeptidase activity
GO:0004888	9.535e-03	10.15	24 ACVR1, ADRA2A, BMPR2, CCRL1, CORIN, FAS, GPR183, GPR37, GRIK2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HTR2A, HTR2B, ICAM1, IL1RAP, IL1RL1, IL6ST, LGALS3BP, NPC1, SEMA5A, TM2D1	334	transmembrane receptor activity
GO:0019838	1.273e-02	1.915	9 ACVR1, FURIN, HTRA1, IGFBP5, IGFBP7, IL1RAP, IL1RL1, IL6ST, PDGFA	63	growth factor binding
GO:0008484	1.639e-02	0.3039	4 GNS, IDS, SGSH, SULF1	10	sulfuric ester hydrolase activity
GO:0030246	1.837e-02	4.012	13 CD302, CLEC2B, FGF1, FGF2, GAA, GALNT3, GPNMB, HBEGF, MAN2B1, MAN2B2, STBD1, VEGFA, VEGFB	132	carbohydrate binding
GO:0004553	2.850e-02	1.337	7 GAA, HEXA, IDUA, MAN1C1, MAN2B1, MAN2B2, MANBA	44	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0043565	3.056e-02	7.933	19 FOSB, HLX, HOXB5, HOXB6, HOXB7, JMJD3, JUND, MAF, MEIS1, MEIS3P1, NFIL3, NFKB1, NR3C1, NR4A3, PPARD, SRF, TBX3, VDR, ZEB1	261	sequence-specific DNA binding
GO:0015923	4.616e-02	0.4255	4 MAN1C1, MAN2B1, MAN2B2, MANBA	14	mannosidase activity
GO:0003700	4.796e-02	14.68	28 BHLHE40, CBFB, EGR2, EGR3, FOSB, HHEX, HLX, HOXB5, HOXB7, JUND, MAF, MEIS1, MEIS3P1, NFATC1, NFIL3, NFKB1, NR3C1, NR4A3, PPARD, RUNX1, SCML2, SOX4, SRF, TBX3, TRIM22, VDR, ZEB1, ZNF35	483	transcription factor activity

Id	Pvalue	ExpCount	Count	Size	Term
01032	2.782e-04	0.9197	8 GNS, HEXA, IDS, IDUA, MAN2B1, MAN2B2, MANBA, SGSH	23	Glycan structures - degradation
04060	6.382e-04	4.878	17 ACVR1, BMPR2, CCL2, CSF1, FAS, IL11, IL1RAP, IL23A, IL6, IL6ST, IL8, LIF, PDGFA, TNFRSF11B, TNFSF4, VEGFA, VEGFB	122	Cytokine-cytokine receptor interaction
05332	1.382e-03	0.8397	7 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, IL6	21	Graft-versus-host disease
05330	1.101e-02	0.8397	6 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	21	Allograft rejection
00531	1.257e-02	0.5598	5 GNS, HEXA, IDS, IDUA, SGSH	14	Glycosaminoglycan degradation
05320	1.381e-02	0.8797	6 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	22	Autoimmune thyroid disease
04610	2.168e-02	1.36	7 C1R, C1S, CD55, F10, F3, PLAUR, PROS1	34	Complement and coagulation cascades
04940	2.835e-02	1.04	6 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	26	Type I diabetes mellitus
00511	3.885e-02	0.4398	4 HEXA, MAN2B1, MAN2B2, MANBA	11	N-Glycan degradation

No enriched terms

No enriched terms

Entrez genes

ABLIM3actin binding LIM protein family, member 3 (205730_s_at), score: 0.21 ACBD3acyl-Coenzyme A binding domain containing 3 (202323_s_at), score: 0.22 ACVR1activin A receptor, type I (203935_at), score: 0.23 ADRA2Aadrenergic, alpha-2A-, receptor (209869_at), score: 0.43 AJAP1adherens junctions associated protein 1 (206460_at), score: 0.31 ANGPTL4angiopoietin-like 4 (221009_s_at), score: 0.51 ANO1anoctamin 1, calcium activated chloride channel (218804_at), score: 0.23 ARID5AAT rich interactive domain 5A (MRF1-like) (213138_at), score: 0.28 ATP13A3ATPase type 13A3 (219558_at), score: 0.34 BCL7AB-cell CLL/lymphoma 7A (203795_s_at), score: 0.25 BHLHE40basic helix-loop-helix family, member e40 (201170_s_at), score: 0.25 BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) (210214_s_at), score: 0.3 C17orf91chromosome 17 open reading frame 91 (214696_at), score: 0.33 C19orf28chromosome 19 open reading frame 28 (220178_at), score: 0.27 C1Rcomplement component 1, r subcomponent (212067_s_at), score: 0.48 C1Scomplement component 1, s subcomponent (208747_s_at), score: 0.32 C9orf167chromosome 9 open reading frame 167 (219620_x_at), score: 0.3 CADPS2Ca++-dependent secretion activator 2 (219572_at), score: 0.33 CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (211368_s_at), score: 0.22 CASP4caspase 4, apoptosis-related cysteine peptidase (209310_s_at), score: 0.27 CBFBcore-binding factor, beta subunit (206788_s_at), score: 0.23 CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b (209682_at), score: 0.29 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: 0.39 CCRL1chemokine (C-C motif) receptor-like 1 (220351_at), score: 0.23 CD302CD302 molecule (203799_at), score: 0.34 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: 0.29 CDC42SE1CDC42 small effector 1 (218157_x_at), score: 0.28 CFHR1complement factor H-related 1 (215388_s_at), score: 0.21 CHIC2cysteine-rich hydrophobic domain 2 (219492_at), score: 0.22 CLEC2BC-type lectin domain family 2, member B (209732_at), score: 0.25 CLIP3CAP-GLY domain containing linker protein 3 (212358_at), score: 0.21 COL15A1collagen, type XV, alpha 1 (203477_at), score: 0.57 CORINcorin, serine peptidase (220356_at), score: 0.21 CPZcarboxypeptidase Z (211062_s_at), score: 0.4 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: 0.44 CSF1colony stimulating factor 1 (macrophage) (209716_at), score: 0.22 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: 0.27 CST3cystatin C (201360_at), score: 0.36 CTSAcathepsin A (200661_at), score: 0.28 CTSOcathepsin O (203758_at), score: 0.28 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: 0.3 DCNdecorin (211896_s_at), score: 0.35 DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked (205000_at), score: 0.32 DENND3DENN/MADD domain containing 3 (212975_at), score: 0.24 DESdesmin (202222_s_at), score: -1 DGKDdiacylglycerol kinase, delta 130kDa (208072_s_at), score: 0.37 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: 0.28 DNAJC1DnaJ (Hsp40) homolog, subfamily C, member 1 (218409_s_at), score: 0.24 DNASE2deoxyribonuclease II, lysosomal (214992_s_at), score: 0.25 DOCK9dedicator of cytokinesis 9 (212538_at), score: 0.29 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: 0.36 DRAMdamage-regulated autophagy modulator (218627_at), score: 0.22 DUSP3dual specificity phosphatase 3 (201537_s_at), score: 0.22 ECM1extracellular matrix protein 1 (209365_s_at), score: 0.36 EDN1endothelin 1 (218995_s_at), score: 0.24 EFHD1EF-hand domain family, member D1 (209343_at), score: 0.21 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: 0.21 EGR3early growth response 3 (206115_at), score: 0.37 EIF1AYeukaryotic translation initiation factor 1A, Y-linked (204409_s_at), score: 0.24 ERAP1endoplasmic reticulum aminopeptidase 1 (214012_at), score: 0.27 F10coagulation factor X (205620_at), score: 0.31 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: 0.27 FADS3fatty acid desaturase 3 (216080_s_at), score: 0.27 FASFas (TNF receptor superfamily, member 6) (216252_x_at), score: 0.3 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: 0.27 FGF2fibroblast growth factor 2 (basic) (204421_s_at), score: 0.24 FGF5fibroblast growth factor 5 (210310_s_at), score: 0.22 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: 0.37 FHOD1formin homology 2 domain containing 1 (218530_at), score: 0.31 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: 0.44 FURINfurin (paired basic amino acid cleaving enzyme) (201945_at), score: 0.24 GAAglucosidase, alpha; acid (202812_at), score: 0.24 GALNT3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (203397_s_at), score: 0.22 GAP43growth associated protein 43 (204471_at), score: -0.9 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: 0.39 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: 0.35 GNSglucosamine (N-acetyl)-6-sulfatase (203676_at), score: 0.25 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: 0.69 GPR183G protein-coupled receptor 183 (205419_at), score: 0.26 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: 0.29 GPX3glutathione peroxidase 3 (plasma) (214091_s_at), score: 0.28 GRAMD3GRAM domain containing 3 (218706_s_at), score: 0.34 GRIK2glutamate receptor, ionotropic, kainate 2 (213845_at), score: 0.23 GRNgranulin (211284_s_at), score: 0.36 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: 0.22 H2BFSH2B histone family, member S (208579_x_at), score: 0.22 HBEGFheparin-binding EGF-like growth factor (203821_at), score: 0.43 HEXAhexosaminidase A (alpha polypeptide) (201765_s_at), score: 0.21 HHEXhematopoietically expressed homeobox (215933_s_at), score: 0.29 HIPK3homeodomain interacting protein kinase 3 (210148_at), score: 0.25 HIST1H2AChistone cluster 1, H2ac (215071_s_at), score: 0.27 HIST1H2BKhistone cluster 1, H2bk (209806_at), score: 0.23 HK2hexokinase 2 (202934_at), score: 0.35 HLA-Amajor histocompatibility complex, class I, A (217436_x_at), score: 0.33 HLA-Bmajor histocompatibility complex, class I, B (211911_x_at), score: 0.36 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: 0.52 HLA-Emajor histocompatibility complex, class I, E (200904_at), score: 0.5 HLA-Fmajor histocompatibility complex, class I, F (204806_x_at), score: 0.44 HLXH2.0-like homeobox (214438_at), score: 0.22 HMOX1heme oxygenase (decycling) 1 (203665_at), score: 0.37 HOXB5homeobox B5 (205601_s_at), score: 0.22 HOXB6homeobox B6 (205366_s_at), score: 0.45 HOXB7homeobox B7 (204779_s_at), score: 0.33 HPCAL1hippocalcin-like 1 (205462_s_at), score: 0.25 HSPB7heat shock 27kDa protein family, member 7 (cardiovascular) (218934_s_at), score: 0.21 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: 0.27 HTR2B5-hydroxytryptamine (serotonin) receptor 2B (206638_at), score: 0.26 HTRA1HtrA serine peptidase 1 (201185_at), score: 0.26 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: 0.26 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: 0.26 IDSiduronate 2-sulfatase (202439_s_at), score: 0.25 IDUAiduronidase, alpha-L- (205059_s_at), score: 0.27 IGFBP5insulin-like growth factor binding protein 5 (203424_s_at), score: 0.24 IGFBP7insulin-like growth factor binding protein 7 (201162_at), score: 0.33 IL11interleukin 11 (206924_at), score: 0.33 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: 0.36 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: 0.22 IL23Ainterleukin 23, alpha subunit p19 (211796_s_at), score: 0.23 IL6interleukin 6 (interferon, beta 2) (205207_at), score: 0.48 IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor) (204864_s_at), score: 0.29 IL8interleukin 8 (202859_x_at), score: 0.28 INPP1inositol polyphosphate-1-phosphatase (202794_at), score: 0.22 ITGA1integrin, alpha 1 (214660_at), score: 0.29 ITPR3inositol 1,4,5-triphosphate receptor, type 3 (201189_s_at), score: 0.24 JARID1Djumonji, AT rich interactive domain 1D (206700_s_at), score: 0.21 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: 0.24 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: 0.39 JUNDjun D proto-oncogene (203751_x_at), score: 0.28 KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (204401_at), score: 0.22 KHDRBS3KH domain containing, RNA binding, signal transduction associated 3 (209781_s_at), score: 0.31 KIAA0247KIAA0247 (202181_at), score: 0.27 KLHL21kelch-like 21 (Drosophila) (203068_at), score: 0.36 KPNA4karyopherin alpha 4 (importin alpha 3) (209653_at), score: 0.23 LBHlimb bud and heart development homolog (mouse) (221011_s_at), score: 0.25 LEPROTleptin receptor overlapping transcript (202378_s_at), score: 0.22 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: 0.24 LHFPlipoma HMGIC fusion partner (218656_s_at), score: 0.26 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: 0.41 LIMS1LIM and senescent cell antigen-like domains 1 (207198_s_at), score: 0.26 LITAFlipopolysaccharide-induced TNF factor (200706_s_at), score: 0.21 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: 0.41 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.4 LOC100128809similar to hCG2045829 (215707_s_at), score: 0.33 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: 0.22 LY96lymphocyte antigen 96 (206584_at), score: 0.25 MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (209348_s_at), score: 0.29 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: 0.28 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: 0.4 MAN2B1mannosidase, alpha, class 2B, member 1 (209166_s_at), score: 0.23 MAN2B2mannosidase, alpha, class 2B, member 2 (214703_s_at), score: 0.23 MANBAmannosidase, beta A, lysosomal (203778_at), score: 0.22 MAP1Smicrotubule-associated protein 1S (218522_s_at), score: 0.23 MAP3K4mitogen-activated protein kinase kinase kinase 4 (216199_s_at), score: 0.26 MAP3K7IP2mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (210284_s_at), score: 0.27 MEIS1Meis homeobox 1 (204069_at), score: 0.3 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: 0.37 MFAP4microfibrillar-associated protein 4 (212713_at), score: 0.41 MTSS1metastasis suppressor 1 (203037_s_at), score: 0.3 MYO1Dmyosin ID (212338_at), score: 0.23 NAB1NGFI-A binding protein 1 (EGR1 binding protein 1) (208047_s_at), score: 0.22 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: 0.29 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: 0.44 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: 0.24 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: 0.4 NID1nidogen 1 (202008_s_at), score: 0.4 NINJ1ninjurin 1 (203045_at), score: 0.32 NPnucleoside phosphorylase (201695_s_at), score: 0.22 NPC1Niemann-Pick disease, type C1 (202679_at), score: 0.28 NPC2Niemann-Pick disease, type C2 (200701_at), score: 0.51 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: 0.22 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: 0.43 NRXN3neurexin 3 (205795_at), score: 0.21 OLFML2Aolfactomedin-like 2A (213075_at), score: 0.27 OS9osteosarcoma amplified 9, endoplasmic reticulum associated protein (200714_x_at), score: 0.26 OSTM1osteopetrosis associated transmembrane protein 1 (218196_at), score: 0.29 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: 0.36 PDGFDplatelet derived growth factor D (219304_s_at), score: 0.34 PDLIM3PDZ and LIM domain 3 (209621_s_at), score: 0.24 PIGBphosphatidylinositol glycan anchor biosynthesis, class B (214151_s_at), score: 0.22 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: 0.27 PIONpigeon homolog (Drosophila) (222150_s_at), score: 0.23 PKP2plakophilin 2 (207717_s_at), score: 0.35 PLAURplasminogen activator, urokinase receptor (211924_s_at), score: 0.24 PLSCR4phospholipid scramblase 4 (218901_at), score: 0.22 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: 0.49 PPAP2Aphosphatidic acid phosphatase type 2A (209147_s_at), score: 0.34 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: 0.31 PROS1protein S (alpha) (207808_s_at), score: 0.24 PSAPprosaposin (200866_s_at), score: 0.22 PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (209040_s_at), score: 0.21 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: 0.36 RANBP2RAN binding protein 2 (201711_x_at), score: 0.27 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: 0.22 RCAN2regulator of calcineurin 2 (203498_at), score: 0.31 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: 0.26 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: 0.36 RNASET2ribonuclease T2 (217983_s_at), score: 0.22 RPS4Y1ribosomal protein S4, Y-linked 1 (201909_at), score: 0.39 RRADRas-related associated with diabetes (204803_s_at), score: 0.5 RUNX1runt-related transcription factor 1 (209360_s_at), score: 0.35 SAT1spermidine/spermine N1-acetyltransferase 1 (213988_s_at), score: 0.28 SCARB1scavenger receptor class B, member 1 (201819_at), score: 0.26 SCARB2scavenger receptor class B, member 2 (201647_s_at), score: 0.24 SCG2secretogranin II (chromogranin C) (204035_at), score: 0.21 SCML2sex comb on midleg-like 2 (Drosophila) (206147_x_at), score: 0.21 SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (205405_at), score: 0.21 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: 0.34 SETXsenataxin (201964_at), score: 0.23 SFRP1secreted frizzled-related protein 1 (202036_s_at), score: 0.25 SFRS5splicing factor, arginine/serine-rich 5 (212266_s_at), score: 0.23 SGSHN-sulfoglucosamine sulfohydrolase (35626_at), score: 0.22 SH3BGRLSH3 domain binding glutamic acid-rich protein like (201311_s_at), score: 0.24 SLC10A3solute carrier family 10 (sodium/bile acid cotransporter family), member 3 (204928_s_at), score: 0.22 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: 0.34 SLC1A1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 (213664_at), score: 0.26 SLC20A2solute carrier family 20 (phosphate transporter), member 2 (202744_at), score: 0.25 SMOXspermine oxidase (210357_s_at), score: 0.33 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: 0.32 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: 0.33 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: 0.33 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: 0.39 SQLEsqualene epoxidase (213562_s_at), score: 0.22 SQRDLsulfide quinone reductase-like (yeast) (217995_at), score: 0.24 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: 0.26 STBD1starch binding domain 1 (203986_at), score: 0.22 STK38Lserine/threonine kinase 38 like (212572_at), score: 0.34 STOMstomatin (201060_x_at), score: 0.25 SULF1sulfatase 1 (212353_at), score: 0.39 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: 0.32 TBX3T-box 3 (219682_s_at), score: 0.37 TCTN1tectonic family member 1 (218584_at), score: 0.21 TEX2testis expressed 2 (218099_at), score: 0.33 TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) (201042_at), score: 0.25 TM2D1TM2 domain containing 1 (211703_s_at), score: 0.46 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: 0.29 TMEM39Atransmembrane protein 39A (218615_s_at), score: 0.26 TMEM41Btransmembrane protein 41B (212623_at), score: 0.48 TNFAIP2tumor necrosis factor, alpha-induced protein 2 (202510_s_at), score: 0.36 TNFRSF11Btumor necrosis factor receptor superfamily, member 11b (204933_s_at), score: 0.37 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: 0.34 TNS3tensin 3 (217853_at), score: 0.29 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: 0.21 TP53I11tumor protein p53 inducible protein 11 (214667_s_at), score: 0.35 TPD52tumor protein D52 (201690_s_at), score: 0.24 TPP1tripeptidyl peptidase I (200742_s_at), score: 0.59 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: 0.36 TPST2tyrosylprotein sulfotransferase 2 (204079_at), score: 0.22 TRAF3TNF receptor-associated factor 3 (221571_at), score: 0.22 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: 0.45 TRIM22tripartite motif-containing 22 (213293_s_at), score: 0.31 TTPALtocopherol (alpha) transfer protein-like (219633_at), score: 0.23 UBA7ubiquitin-like modifier activating enzyme 7 (203281_s_at), score: 0.21 UBE3Bubiquitin protein ligase E3B (212403_at), score: 0.22 UTP3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) (209486_at), score: 0.22 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (204255_s_at), score: 0.21 VEGFAvascular endothelial growth factor A (211527_x_at), score: 0.42 VEGFBvascular endothelial growth factor B (203683_s_at), score: 0.26 WTAPWilms tumor 1 associated protein (210285_x_at), score: 0.28 WWTR1WW domain containing transcription regulator 1 (202132_at), score: 0.27 YIPF6Yip1 domain family, member 6 (212341_at), score: 0.29 YRDCyrdC domain containing (E. coli) (218647_s_at), score: 0.28 ZEB1zinc finger E-box binding homeobox 1 (212758_s_at), score: 0.23 ZMYM6zinc finger, MYM-type 6 (219924_s_at), score: 0.26 ZNF282zinc finger protein 282 (212892_at), score: 0.22 ZNF35zinc finger protein 35 (206096_at), score: 0.3

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
1Twin.CEL	1	2	DS-twin	hgu133plus2	Down	DS-twin 1
6Twin.CEL	6	2	DS-twin	hgu133plus2	none	DS-twin 6
5CTwin.CEL	5	2	DS-twin	hgu133plus2	Down	DS-twin 5
2Twin.CEL	2	2	DS-twin	hgu133plus2	none	DS-twin 2
46A.CEL	1	3	DS-mosaic	hgu133plus2	none	DS-mosaic 1