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skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

blood vessel development

The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

cell activation

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

antigen processing and presentation of peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins during acute inflammatory response

Any process activating plasma proteins via proteolysis during an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

protein amino acid phosphorylation

The process of introducing a phosphate group on to a protein.

proteolysis

The hydrolysis of a peptide bond or bonds within a protein.

phosphorus metabolic process

The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).

phosphate metabolic process

The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.

cell motion

Any process involved in the controlled movement of a cell.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

humoral immune response

An immune response mediated through a body fluid.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

intracellular signaling cascade

A series of reactions within the cell that occur as a result of a single trigger reaction or compound.

protein kinase cascade

A series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of protein kinase cascade

Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of protein kinase cascade

Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

phosphorylation

The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

cell migration

The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.

peptidyl-serine phosphorylation

The posttranslational phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

peptidyl-amino acid modification

The alteration of an amino acid residue in a peptide.

peptidyl-serine modification

The modification of peptidyl-serine.

regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

antigen processing and presentation

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

regulation of peptidyl-serine phosphorylation

Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.

positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

locomotion

Self-propelled movement of a cell or organism from one location to another.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of locomotion

Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

biopolymer modification

The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties.

post-translational protein modification

The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

antigen processing and presentation of peptide antigen

The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of behavior

Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

tissue remodeling

The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of behavior

Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

positive chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a higher concentration, in a concentration gradient of a specific chemical.

regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

regulation of positive chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

positive regulation of positive chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

induction of positive chemotaxis

Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of phosphorus metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

localization of cell

Any process by which a cell is transported to, and/or maintained in, a specific location.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of locomotion

Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of macromolecule metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

regulation of cellular metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

positive regulation of locomotion

Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of behavior

Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

regulation of behavior

Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

cell motion

Any process involved in the controlled movement of a cell.

positive regulation of cellular metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.

positive regulation of macromolecule metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of phosphorus metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of behavior

Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of phosphorus metabolic process

Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

regulation of phosphate metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

protein modification process

The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).

regulation of cellular protein metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of cellular protein metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

positive regulation of positive chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

regulation of positive chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

positive regulation of positive chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

positive regulation of phosphate metabolic process

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.

regulation of protein modification process

Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

positive regulation of protein modification process

Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.

regulation of phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

regulation of protein kinase cascade

Any process that modulates the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

positive regulation of protein kinase cascade

Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

positive regulation of protein kinase cascade

Any process that increases the rate, frequency or extent of a series of reactions, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

activation of plasma proteins during acute inflammatory response

Any process activating plasma proteins via proteolysis during an acute inflammatory response.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

protein amino acid phosphorylation

The process of introducing a phosphate group on to a protein.

regulation of protein amino acid phosphorylation

Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.

positive regulation of protein amino acid phosphorylation

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

peptidyl-serine phosphorylation

The posttranslational phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

regulation of peptidyl-serine phosphorylation

Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-serine.

positive regulation of peptidyl-serine phosphorylation

Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cell surface

The external part of the cell wall and/or plasma membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

MHC class I receptor activity

Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

This term is the most general term possible

Id	Pvalue	ExpCount	Count	Size	Term
GO:0002376	8.372e-09	12.43	40 C1R, C1S, CBFB, CCL2, CD55, CFHR1, CLU, DNASE2, DPP4, ERAP1, ERAP2, GEM, GPR183, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL11, IL1RAP, IL23A, IL6, IL6ST, IL8, ITGA1, JARID2, LIF, NFIL3, NFKB1, PSMB9, RUNX1, SCG2, SHB, SOX4, TNFSF4, TPD52, TRIM22, VEGFA	475	immune system process
GO:0009611	7.879e-08	6.047	26 C1R, C1S, CCL2, CD55, CFHR1, CLU, F10, FGF7, HBEGF, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, NFKB1, NINJ1, PDGFA, PLAUR, PPARD, PROS1, SCG2, SRF, TGM2, TPST1	231	response to wounding
GO:0006955	2.728e-06	7.723	27 C1R, C1S, CCL2, CD55, CFHR1, CLU, ERAP1, ERAP2, GEM, GPR183, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL1RAP, IL23A, IL6, IL6ST, IL8, LIF, NFIL3, PSMB9, TNFSF4, TRIM22	295	immune response
GO:0048518	3.143e-06	22.72	51 ABLIM3, ADRA2A, AGRN, ANGPTL4, BMPR2, C1R, C1S, CASP4, CBFB, CCL2, CD55, CFHR1, CLU, ECM1, ERAP1, FGF7, FURIN, HBEGF, HHEX, HMOX1, ICAM1, IL11, IL6, IL6ST, IL8, JUND, LIF, LITAF, LTBR, MAP3K7IP2, NAMPT, NFKB1, NR4A3, P2RX4, PCBD1, PDGFA, PPARD, RUNX1, SCG2, SOX4, SRF, TBX3, TGM2, TM2D1, TNFSF4, TNS3, TP53BP2, TRAF3, VEGFA, VEGFB, WWTR1	868	positive regulation of biological process
GO:0009605	6.018e-06	9.686	30 C1R, C1S, CCL2, CD55, CFHR1, CLU, F10, FGF7, HBEGF, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, ITGA1, JMJD3, NFKB1, NINJ1, NR4A3, PDGFA, PLAUR, PPARD, PROS1, SCG2, SLC10A3, SRF, TGM2, TPST1, VEGFA	370	response to external stimulus
GO:0002474	2.683e-05	0.445	7 ERAP1, ERAP2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	17	antigen processing and presentation of peptide antigen via MHC class I
GO:0048513	2.811e-05	19.45	44 AGRN, ANGPTL4, BBS1, BMPR2, CBFB, CCL2, CLU, COL15A1, CST3, DCN, DNASE2, EGR3, ERAP1, FGF7, GAA, GPNMB, HBEGF, HHEX, HMOX1, IDUA, IL11, IL6, IL8, JARID2, LIF, MAP1S, NFKB1, NINJ1, NR4A3, PDLIM3, PPARD, RUNX1, SCG2, SHB, SOX4, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, VEGFA	743	organ development
GO:0042127	3.552e-05	9.974	29 ADRA2A, BMPR2, CCL2, CLU, FGF7, GPNMB, HBEGF, HHEX, HMOX1, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, LIF, NAMPT, PDGFA, SCG2, SOX4, TBX3, TGM2, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA, VEGFB	381	regulation of cell proliferation
GO:0032502	4.926e-05	49.82	82 AGRN, ANGPTL4, BBS1, BMPR2, CASP4, CBFB, CCL2, CDC42SE1, CLU, COL15A1, CREG1, CST3, DCN, DGKD, DNASE2, DRAM, EGR3, EPHA2, ERAP1, FGF7, FOSB, FURIN, GAA, GNPTAB, GPNMB, HBEGF, HHEX, HIPK3, HMOX1, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JUND, LIF, LITAF, LTBR, MAP1S, MEIS1, MTSS1, NFKB1, NINJ1, NR4A3, NRXN3, P2RX4, PDGFA, PDLIM3, PPARD, RNF130, RPS4Y1, RTN1, RUNX1, SCG2, SERPINB2, SETX, SFRP1, SHB, SOX4, SPATA20, SPRED2, SPRY2, SPRY4, SRF, SULF1, TBX3, TCTN1, TGM2, TM2D1, TNFAIP2, TNFRSF11B, TNS3, TP53BP2, TPD52, TPP1, TRAF3, VEGFA, VEGFB, WWTR1	1903	developmental process
GO:0032501	5.502e-05	43.14	74 ADRA2A, AGRN, ANGPTL4, BBS1, BMPR2, CBFB, CCL2, CLU, COL15A1, CREG1, CST3, DCN, DES, DGKD, DNASE2, EGR3, EPHA2, ERAP1, ERAP2, F10, FGF7, FOSB, FURIN, GAA, GPNMB, HBEGF, HHEX, HMOX1, IDUA, IL11, IL23A, IL6, IL6ST, IL8, JARID2, JUND, LIF, MAN2B1, MAP1S, MEIS1, NFKB1, NINJ1, NR4A3, NRXN3, P2RX4, PDGFA, PDLIM3, PLAUR, PPARD, PROS1, RPS4Y1, RTN1, RUNX1, SCG2, SFRP1, SHB, SLC19A2, SOX4, SPATA20, SPRED2, SPRY2, SPRY4, SRF, STBD1, TBX3, TCTN1, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, VEGFA, WWTR1	1648	multicellular organismal process
GO:0006952	6.385e-05	6.885	23 C1R, C1S, CCL2, CD55, CFHR1, CLU, CST3, ERAP1, H2BFS, HIST1H2BK, HLA-B, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, LGALS3BP, NFKB1, SCG2, TGM2, TPST1	263	defense response
GO:0007275	6.869e-05	33.61	62 AGRN, ANGPTL4, BBS1, BMPR2, CBFB, CCL2, CLU, COL15A1, CREG1, CST3, DCN, DGKD, DNASE2, EGR3, EPHA2, ERAP1, FGF7, FOSB, GAA, GPNMB, HBEGF, HHEX, HMOX1, IDUA, IL11, IL6, IL6ST, IL8, JARID2, JUND, LIF, MAP1S, MEIS1, NFKB1, NINJ1, NR4A3, NRXN3, PDGFA, PDLIM3, PPARD, RPS4Y1, RTN1, RUNX1, SCG2, SFRP1, SHB, SOX4, SPATA20, SPRED2, SPRY2, SPRY4, SRF, TBX3, TCTN1, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, VEGFA, WWTR1	1284	multicellular organismal development
GO:0008284	8.539e-05	4.948	19 ADRA2A, CCL2, CLU, FGF7, HBEGF, IL11, IL6, IL6ST, LIF, NAMPT, PDGFA, SCG2, SOX4, TBX3, TGM2, TNFSF4, TNS3, VEGFA, VEGFB	189	positive regulation of cell proliferation
GO:0006954	8.620e-05	4.005	17 C1R, C1S, CCL2, CD55, CFHR1, CLU, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, NFKB1, SCG2, TGM2, TPST1	153	inflammatory response
GO:0048583	1.226e-04	3.22	15 C1R, C1S, CD55, CFHR1, CLU, ERAP1, HMOX1, ICAM1, IL6, IL6ST, IL8, PDGFA, SCG2, TGM2, VEGFA	123	regulation of response to stimulus
GO:0048002	1.249e-04	0.5498	7 ERAP1, ERAP2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	21	antigen processing and presentation of peptide antigen
GO:0050900	1.311e-04	0.7854	8 CCL2, HMOX1, ICAM1, IL6, IL8, ITGA1, SCG2, VEGFA	30	leukocyte migration
GO:0008283	2.055e-04	14.79	35 ADRA2A, BMPR2, CCL2, CLU, CREG1, FGF7, FURIN, GPNMB, HBEGF, HHEX, HMOX1, IGFBP5, IGFBP7, IL11, IL23A, IL6, IL6ST, IL8, JARID2, LIF, NAMPT, PDGFA, PDGFD, PPARD, SCG2, SHB, SOX4, TBX3, TGM2, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA, VEGFB	565	cell proliferation
GO:0048522	2.305e-04	21.13	44 ABLIM3, ADRA2A, AGRN, BMPR2, CASP4, CBFB, CCL2, CLU, ECM1, FGF7, FURIN, HBEGF, HHEX, HMOX1, ICAM1, IL11, IL6, IL6ST, JUND, LIF, LITAF, LTBR, MAP3K7IP2, NAMPT, NFKB1, NR4A3, P2RX4, PCBD1, PDGFA, PPARD, RUNX1, SCG2, SOX4, SRF, TBX3, TGM2, TM2D1, TNFSF4, TNS3, TP53BP2, TRAF3, VEGFA, VEGFB, WWTR1	807	positive regulation of cellular process
GO:0048584	2.561e-04	1.806	11 C1R, C1S, CD55, CFHR1, CLU, IL6, IL6ST, IL8, SCG2, TGM2, VEGFA	69	positive regulation of response to stimulus
GO:0048731	2.590e-04	26.41	51 AGRN, ANGPTL4, BBS1, BMPR2, CBFB, CCL2, CLU, COL15A1, CST3, DCN, DNASE2, EGR3, EPHA2, ERAP1, FGF7, GAA, GPNMB, HBEGF, HHEX, HMOX1, IDUA, IL11, IL6, IL6ST, IL8, JARID2, JUND, LIF, MAP1S, NFKB1, NINJ1, NR4A3, NRXN3, PDLIM3, PPARD, RTN1, RUNX1, SCG2, SHB, SOX4, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, VEGFA, WWTR1	1009	system development
GO:0009887	3.025e-04	8.168	24 ANGPTL4, BBS1, CCL2, COL15A1, CST3, DCN, ERAP1, GAA, HHEX, HMOX1, IDUA, IL6, IL8, JARID2, NR4A3, SCG2, SHB, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, VEGFA	312	organ morphogenesis
GO:0050896	3.407e-04	35.34	62 ADRA2A, ANGPTL4, BBS1, C1R, C1S, CCL2, CD55, CFHR1, CLU, CST3, DGKD, DPP4, ERAP1, ERAP2, F10, FGF7, FOSB, GAA, GEM, GPR183, GPX3, H2BFS, HBEGF, HIST1H2BK, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL1RAP, IL23A, IL6, IL6ST, IL8, ITGA1, JMJD3, LGALS3BP, LIF, MAN2B1, NFIL3, NFKB1, NINJ1, NR4A3, P2RX4, PDGFA, PLAUR, PPARD, PROS1, PSMB9, SCG2, SETX, SLC10A3, SRF, TGM2, TNFSF4, TP53I11, TPST1, TRIB1, TRIM22, VEGFA	1350	response to stimulus
GO:0048856	3.882e-04	32.28	58 AGRN, ANGPTL4, BBS1, BMPR2, CBFB, CCL2, CDC42SE1, CLU, COL15A1, CST3, DCN, DGKD, DNASE2, EGR3, EPHA2, ERAP1, FGF7, GAA, GPNMB, HBEGF, HHEX, HMOX1, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JUND, LIF, MAP1S, MTSS1, NFKB1, NINJ1, NR4A3, NRXN3, PDLIM3, PPARD, RTN1, RUNX1, SCG2, SFRP1, SHB, SOX4, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TNS3, TPD52, TPP1, VEGFA, VEGFB, WWTR1	1233	anatomical structure development
GO:0048514	6.087e-04	3.246	14 ANGPTL4, COL15A1, CST3, ERAP1, HHEX, HMOX1, IL6, IL8, SCG2, SHB, SRF, TGM2, TNFAIP2, VEGFA	124	blood vessel morphogenesis
GO:0001649	8.482e-04	0.733	7 BMPR2, CBFB, GPNMB, IL6, IL6ST, JUND, WWTR1	28	osteoblast differentiation
GO:0019882	1.047e-03	1.047	8 ERAP1, ERAP2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, ICAM1	40	antigen processing and presentation
GO:0050793	1.235e-03	18.3	38 AGRN, ANGPTL4, BMPR2, CASP4, CCL2, CDC42SE1, CLU, CST3, DGKD, ERAP1, FURIN, HHEX, HIPK3, HMOX1, IGFBP5, IGFBP7, IL6, IL6ST, JUND, LIF, NFKB1, P2RX4, PPARD, RUNX1, SCG2, SERPINB2, SFRP1, SOX4, SRF, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA, VEGFB, WWTR1	699	regulation of developmental process
GO:0006959	1.305e-03	0.7854	7 C1R, C1S, CCL2, CD55, CFHR1, CLU, IL6	30	humoral immune response
GO:0040012	1.308e-03	2.173	11 BBS1, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, PDGFA, SCG2, TRIB1, VEGFA	83	regulation of locomotion
GO:0001568	1.688e-03	3.586	14 ANGPTL4, COL15A1, CST3, ERAP1, HHEX, HMOX1, IL6, IL8, SCG2, SHB, SRF, TGM2, TNFAIP2, VEGFA	137	blood vessel development
GO:0048869	1.786e-03	21.57	42 AGRN, ANGPTL4, BBS1, BMPR2, CBFB, CDC42SE1, CLU, COL15A1, DGKD, DNASE2, EPHA2, ERAP1, GNPTAB, GPNMB, HHEX, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, JUND, LIF, MAP1S, MTSS1, NFKB1, NRXN3, PPARD, RTN1, RUNX1, SFRP1, SHB, SOX4, SPATA20, SPRY2, SRF, TBX3, TNFAIP2, TPD52, VEGFA, VEGFB, WWTR1	824	cellular developmental process
GO:0048870	1.895e-03	4.634	16 BBS1, CCL2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, PDGFA, PPARD, SCG2, SRF, TNS3, TRIB1, VEGFA	177	cell motility
GO:0001944	1.944e-03	3.639	14 ANGPTL4, COL15A1, CST3, ERAP1, HHEX, HMOX1, IL6, IL8, SCG2, SHB, SRF, TGM2, TNFAIP2, VEGFA	139	vasculature development
GO:0001525	2.032e-03	2.723	12 ANGPTL4, COL15A1, ERAP1, HHEX, HMOX1, IL6, IL8, SCG2, SHB, SRF, TNFAIP2, VEGFA	104	angiogenesis
GO:0009967	2.087e-03	3.665	14 ECM1, HMOX1, IL11, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, P2RX4, PPARD, SOX4, TGM2, VEGFA	140	positive regulation of signal transduction
GO:0009653	2.264e-03	18.14	37 ANGPTL4, BBS1, BMPR2, CCL2, CDC42SE1, CLU, COL15A1, CST3, DCN, DGKD, ERAP1, GAA, HHEX, HMOX1, IDUA, IGFBP5, IGFBP7, IL6, IL8, JARID2, MAP1S, MTSS1, NINJ1, NR4A3, NRXN3, SCG2, SFRP1, SHB, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TPD52, VEGFA, VEGFB	693	anatomical structure morphogenesis
GO:0050776	2.519e-03	1.937	10 C1R, C1S, CD55, CFHR1, CLU, ERAP1, HMOX1, ICAM1, IL6, IL6ST	74	regulation of immune response
GO:0006928	2.760e-03	7.042	20 ADRA2A, BBS1, CCL2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, MTSS1, NRXN3, PDGFA, PLAUR, PPARD, SCG2, SRF, TNS3, TRIB1, VEGFA	269	cell motion
GO:0051674	2.760e-03	7.042	20 ADRA2A, BBS1, CCL2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, MTSS1, NRXN3, PDGFA, PLAUR, PPARD, SCG2, SRF, TNS3, TRIB1, VEGFA	269	localization of cell
GO:0048646	3.108e-03	3.822	14 ANGPTL4, BMPR2, COL15A1, ERAP1, HHEX, HMOX1, IL6, IL8, NR4A3, SCG2, SHB, SRF, TNFAIP2, VEGFA	146	anatomical structure formation
GO:0032103	3.247e-03	0.6283	6 IL6, IL6ST, IL8, SCG2, TGM2, VEGFA	24	positive regulation of response to external stimulus
GO:0051239	3.439e-03	8.377	22 AGRN, ANGPTL4, BMPR2, CST3, DES, ERAP1, FURIN, GAA, HBEGF, HHEX, HMOX1, IL6, IL6ST, JUND, LIF, NFKB1, P2RX4, PDGFA, RUNX1, SRF, TBX3, TNFRSF11B	320	regulation of multicellular organismal process
GO:0002682	3.769e-03	3.901	14 C1R, C1S, CD55, CFHR1, CLU, ERAP1, HMOX1, ICAM1, IL6, IL6ST, LIF, NFKB1, RUNX1, VEGFA	149	regulation of immune system process
GO:0010647	3.769e-03	3.901	14 ECM1, HMOX1, IL11, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, P2RX4, PPARD, SOX4, TGM2, VEGFA	149	positive regulation of cell communication
GO:0016477	4.318e-03	4.477	15 CCL2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, PDGFA, PPARD, SCG2, SRF, TNS3, TRIB1, VEGFA	171	cell migration
GO:0002526	4.496e-03	0.9686	7 C1R, C1S, CD55, CFHR1, CLU, IL6, IL6ST	37	acute inflammatory response
GO:0042060	4.503e-03	2.094	10 F10, HBEGF, HMOX1, IL6, NINJ1, PDGFA, PLAUR, PPARD, PROS1, SRF	80	wound healing
GO:0001775	4.535e-03	3.979	14 CBFB, DPP4, HMOX1, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, P2RX4, PDGFA, SHB, SOX4, TPD52	152	cell activation
GO:0010740	5.017e-03	2.566	11 ECM1, HMOX1, IL11, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, PPARD, TGM2	98	positive regulation of protein kinase cascade
GO:0002685	5.565e-03	0.2356	4 HMOX1, ICAM1, IL6, VEGFA	9	regulation of leukocyte migration
GO:0030154	5.882e-03	17.64	35 AGRN, ANGPTL4, BBS1, BMPR2, CBFB, CLU, COL15A1, DNASE2, EPHA2, ERAP1, GNPTAB, GPNMB, HHEX, IL11, IL6, IL6ST, JUND, LIF, MAP1S, NFKB1, NRXN3, PPARD, RTN1, RUNX1, SFRP1, SHB, SOX4, SPATA20, SPRY2, SRF, TBX3, TNFAIP2, TPD52, VEGFA, WWTR1	674	cell differentiation
GO:0002541	5.924e-03	0.445	5 C1R, C1S, CD55, CFHR1, CLU	17	activation of plasma proteins during acute inflammatory response
GO:0006956	5.924e-03	0.445	5 C1R, C1S, CD55, CFHR1, CLU	17	complement activation
GO:0030595	5.924e-03	0.445	5 CCL2, IL6, IL8, ITGA1, SCG2	17	leukocyte chemotaxis
GO:0060326	5.924e-03	0.445	5 CCL2, IL6, IL8, ITGA1, SCG2	17	cell chemotaxis
GO:0045597	6.934e-03	2.225	10 BMPR2, CLU, IL6, IL6ST, JUND, LIF, NFKB1, PPARD, RUNX1, SRF	85	positive regulation of cell differentiation
GO:0033135	7.043e-03	0.1047	3 IL11, IL6, LIF	4	regulation of peptidyl-serine phosphorylation
GO:0033138	7.043e-03	0.1047	3 IL11, IL6, LIF	4	positive regulation of peptidyl-serine phosphorylation
GO:0050930	7.043e-03	0.1047	3 IL8, SCG2, VEGFA	4	induction of positive chemotaxis
GO:0048771	7.145e-03	1.414	8 BMPR2, CST3, IL23A, IL6, IL6ST, JUND, TGM2, TPP1	54	tissue remodeling
GO:0006950	7.722e-03	22.46	41 ADRA2A, ANGPTL4, C1R, C1S, CCL2, CD55, CFHR1, CLU, CST3, DPP4, ERAP1, F10, FGF7, GPX3, H2BFS, HBEGF, HIST1H2BK, HLA-B, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, LGALS3BP, NFKB1, NINJ1, P2RX4, PDGFA, PLAUR, PPARD, PROS1, SCG2, SETX, SRF, TGM2, TP53I11, TPST1, TRIB1, VEGFA	858	response to stress
GO:0040011	8.771e-03	5.969	17 BBS1, CCL2, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, PDGFA, PLAUR, PPARD, SCG2, SRF, TNS3, TRIB1, VEGFA	228	locomotion
GO:0016265	9.712e-03	16.73	33 ANGPTL4, CASP4, CCL2, CLU, CST3, DNASE2, DRAM, FURIN, HIPK3, HMOX1, IL6, IL6ST, LITAF, LTBR, MAP1S, NFKB1, P2RX4, PPARD, RNF130, SCG2, SERPINB2, SETX, SFRP1, SHB, SOX4, SULF1, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA	639	death
GO:0048010	1.153e-02	0.288	4 BMPR2, CCL2, HHEX, VEGFA	11	vascular endothelial growth factor receptor signaling pathway
GO:0007169	1.238e-02	3.927	13 AGRN, BMPR2, CCL2, DGKD, EPHA2, FGF7, HBEGF, HHEX, IGFBP5, MTSS1, PDGFA, RGS2, VEGFA	150	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0006915	1.308e-02	15.6	31 ANGPTL4, CASP4, CCL2, CLU, DNASE2, DRAM, FURIN, HIPK3, HMOX1, IL6, IL6ST, LITAF, LTBR, MAP1S, NFKB1, P2RX4, PPARD, RNF130, SCG2, SERPINB2, SFRP1, SHB, SOX4, SULF1, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA	596	apoptosis
GO:0018209	1.408e-02	0.5498	5 GALNT3, HIPK3, IL11, IL6, LIF	21	peptidyl-serine modification
GO:0048660	1.408e-02	0.5498	5 HBEGF, IGFBP5, IL6, TGM2, TRIB1	21	regulation of smooth muscle cell proliferation
GO:0051241	1.417e-02	1.204	7 BMPR2, CST3, FURIN, HMOX1, IL6, P2RX4, PDGFA	46	negative regulation of multicellular organismal process
GO:0012501	1.467e-02	15.73	31 ANGPTL4, CASP4, CCL2, CLU, DNASE2, DRAM, FURIN, HIPK3, HMOX1, IL6, IL6ST, LITAF, LTBR, MAP1S, NFKB1, P2RX4, PPARD, RNF130, SCG2, SERPINB2, SFRP1, SHB, SOX4, SULF1, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA	601	programmed cell death
GO:0048519	1.485e-02	24.11	42 ANGPTL4, ARID5A, BCL7A, BMPR2, CCL2, CLU, CST3, FOSB, FURIN, GPNMB, HHEX, HIPK3, HMOX1, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JMJD3, LIF, LMCD1, MAF, MTSS1, NAB1, NFKB1, P2RX4, PDGFA, RGS2, SCG2, SERPINB2, SFRP1, SOX4, TBX3, TNFRSF11B, TP53BP2, TP53I11, TRIB1, VEGFA, WT1, WWTR1	921	negative regulation of biological process
GO:0051093	1.582e-02	7.592	19 ANGPTL4, CCL2, CLU, CST3, FURIN, HHEX, HIPK3, HMOX1, IL6, IL6ST, NFKB1, SCG2, SERPINB2, SFRP1, SOX4, TBX3, TNFRSF11B, VEGFA, WWTR1	290	negative regulation of developmental process
GO:0006357	1.627e-02	9.555	22 ABLIM3, AGRN, CBFB, CREG1, FOSB, HHEX, HMOX1, IL11, IL6, JARID2, JMJD3, JUND, LIF, LITAF, LMCD1, NFKB1, NR4A3, RUNX1, SRF, TBX3, WT1, WWTR1	365	regulation of transcription from RNA polymerase II promoter
GO:0048659	1.683e-02	0.5759	5 HBEGF, IGFBP5, IL6, TGM2, TRIB1	22	smooth muscle cell proliferation
GO:0008219	1.747e-02	16.68	32 ANGPTL4, CASP4, CCL2, CLU, DNASE2, DRAM, FURIN, HIPK3, HMOX1, IL6, IL6ST, LITAF, LTBR, MAP1S, NFKB1, P2RX4, PPARD, RNF130, SCG2, SERPINB2, SETX, SFRP1, SHB, SOX4, SULF1, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA	637	cell death
GO:0045321	1.801e-02	3.586	12 CBFB, DPP4, HMOX1, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, SHB, SOX4, TPD52	137	leukocyte activation
GO:0010627	1.888e-02	3.089	11 ECM1, HMOX1, IL11, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, PPARD, TGM2	118	regulation of protein kinase cascade
GO:0043066	1.979e-02	5.314	15 ANGPTL4, CCL2, CLU, FURIN, HIPK3, HMOX1, IL6, IL6ST, NFKB1, SCG2, SERPINB2, SFRP1, SOX4, TBX3, VEGFA	203	negative regulation of apoptosis
GO:0051094	1.999e-02	7.775	19 ANGPTL4, BMPR2, CASP4, CLU, ERAP1, HMOX1, IL6, IL6ST, JUND, LIF, NFKB1, PPARD, RUNX1, SOX4, SRF, TGM2, TM2D1, TP53BP2, TRAF3	297	positive regulation of developmental process
GO:0002684	2.011e-02	2.147	9 C1R, C1S, CD55, CFHR1, CLU, ICAM1, IL6, IL6ST, VEGFA	82	positive regulation of immune system process
GO:0040017	2.016e-02	0.3403	4 IL6, IL8, SCG2, VEGFA	13	positive regulation of locomotion
GO:0048520	2.016e-02	0.3403	4 IL6, IL8, SCG2, VEGFA	13	positive regulation of behavior
GO:0050920	2.016e-02	0.3403	4 IL6, IL8, SCG2, VEGFA	13	regulation of chemotaxis
GO:0050921	2.016e-02	0.3403	4 IL6, IL8, SCG2, VEGFA	13	positive regulation of chemotaxis
GO:0043069	2.227e-02	5.393	15 ANGPTL4, CCL2, CLU, FURIN, HIPK3, HMOX1, IL6, IL6ST, NFKB1, SCG2, SERPINB2, SFRP1, SOX4, TBX3, VEGFA	206	negative regulation of programmed cell death
GO:0009966	2.290e-02	9.869	22 ECM1, HHEX, HMOX1, IGFBP5, IL11, IL6, IL6ST, LIF, LITAF, LTBR, MAP3K7IP2, P2RX4, PPARD, RAMP1, RGS2, SOX4, SPRED2, SPRY2, SPRY4, TGM2, TRIB1, VEGFA	377	regulation of signal transduction
GO:0014910	2.351e-02	0.1571	3 IGFBP5, PDGFA, TRIB1	6	regulation of smooth muscle cell migration
GO:0050918	2.351e-02	0.1571	3 IL8, SCG2, VEGFA	6	positive chemotaxis
GO:0050926	2.351e-02	0.1571	3 IL8, SCG2, VEGFA	6	regulation of positive chemotaxis
GO:0050927	2.351e-02	0.1571	3 IL8, SCG2, VEGFA	6	positive regulation of positive chemotaxis
GO:0006958	2.543e-02	0.3665	4 C1R, C1S, CD55, CLU	14	complement activation, classical pathway
GO:0045669	2.543e-02	0.3665	4 BMPR2, IL6, IL6ST, JUND	14	positive regulation of osteoblast differentiation
GO:0050795	2.543e-02	0.3665	4 IL6, IL8, SCG2, VEGFA	14	regulation of behavior
GO:0032101	2.550e-02	1.361	7 IL6, IL6ST, IL8, PDGFA, SCG2, TGM2, VEGFA	52	regulation of response to external stimulus
GO:0007610	2.642e-02	4.346	13 BBS1, CCL2, FOSB, GAA, IL6, IL8, ITGA1, MAN2B1, NR4A3, PDGFA, PLAUR, SCG2, VEGFA	166	behavior
GO:0045944	2.667e-02	3.796	12 ABLIM3, AGRN, CBFB, HHEX, IL11, IL6, LIF, NFKB1, NR4A3, RUNX1, SRF, WWTR1	145	positive regulation of transcription from RNA polymerase II promoter
GO:0045444	2.712e-02	0.6545	5 BBS1, ERAP1, IL11, PPARD, WWTR1	25	fat cell differentiation
GO:0006935	2.718e-02	1.806	8 CCL2, IL6, IL8, ITGA1, PDGFA, PLAUR, SCG2, VEGFA	69	chemotaxis
GO:0042330	2.718e-02	1.806	8 CCL2, IL6, IL8, ITGA1, PDGFA, PLAUR, SCG2, VEGFA	69	taxis
GO:0048523	2.918e-02	22.75	39 ANGPTL4, ARID5A, BCL7A, CCL2, CLU, CST3, FOSB, FURIN, GPNMB, HHEX, HIPK3, HMOX1, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JMJD3, LIF, LMCD1, MAF, MTSS1, NAB1, NFKB1, PDGFA, RGS2, SCG2, SERPINB2, SFRP1, SOX4, TBX3, TP53BP2, TP53I11, TRIB1, VEGFA, WT1, WWTR1	869	negative regulation of cellular process
GO:0006366	3.100e-02	12.98	26 ABLIM3, AGRN, BMPR2, CBFB, CREG1, FOSB, HHEX, HMOX1, IL11, IL6, JARID2, JMJD3, JUND, LIF, LITAF, LMCD1, MAF, NFATC1, NFIL3, NFKB1, NR4A3, RUNX1, SRF, TBX3, WT1, WWTR1	496	transcription from RNA polymerase II promoter
GO:0051260	3.102e-02	0.6806	5 DGKD, GPX3, PCBD1, STOM, TGM2	26	protein homooligomerization
GO:0002455	3.122e-02	0.3927	4 C1R, C1S, CD55, CLU	15	humoral immune response mediated by circulating immunoglobulin
GO:0051270	3.325e-02	2.356	9 BBS1, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, PDGFA, TRIB1, VEGFA	90	regulation of cell motion
GO:0009617	3.332e-02	1.047	6 CCL2, ERAP1, H2BFS, HIST1H2BK, IL6, TRIB1	40	response to bacterium
GO:0014909	3.447e-02	0.1833	3 IGFBP5, PDGFA, TRIB1	7	smooth muscle cell migration
GO:0042517	3.447e-02	0.1833	3 IL6, IL6ST, LIF	7	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0050730	3.526e-02	0.7068	5 IL11, IL6, IL6ST, LIF, PDGFD	27	regulation of peptidyl-tyrosine phosphorylation
GO:0065007	3.677e-02	98.64	121 ABLIM3, ADRA2A, AGRN, ANGPTL4, ANK2, ARID5A, BBS1, BCL7A, BMPR2, C1R, C1S, CASP4, CBFB, CCL2, CD55, CDC42SE1, CFHR1, CLU, CPZ, CREG1, CST3, DES, DGKD, DNASE2, DPP4, ECM1, EGR3, EPHA2, ERAP1, ERAP2, F10, FGF7, FOSB, FURIN, GAA, GEM, GPNMB, GPR183, GPR37, GRN, HBEGF, HHEX, HIPK3, HIVEP1, HMOX1, ICAM1, IDUA, IGFBP5, IGFBP7, IL11, IL1RAP, IL6, IL6ST, IL8, ITGA1, JARID2, JMJD3, JUND, KHDRBS3, LGALS3BP, LIF, LITAF, LMCD1, LTBR, LYN, MAF, MAP3K7IP2, MEIS1, MEIS3P1, MFAP4, MTSS1, NAB1, NAMPT, NFATC1, NFIL3, NFKB1, NPC2, NR4A3, P2RX4, PCBD1, PDGFA, PDGFD, PLAUR, PMEPA1, PPARD, PROS1, PSMB9, RAMP1, RGS2, RRAD, RUNX1, SCG2, SERPINB2, SFRP1, SHB, SOX4, SPRED2, SPRY2, SPRY4, SRF, STK38L, TBX3, TEX2, TGM2, TM2D1, TNFRSF11B, TNFSF4, TNS3, TP53BP2, TP53I11, TPP1, TRAF3, TRIB1, TRIM22, VEGFA, VEGFB, WT1, WWTR1, ZNF282, ZNF35, ZNF672	3768	biological regulation
GO:0002443	3.797e-02	1.492	7 C1R, C1S, CD55, CLU, HMOX1, ICAM1, IL6	57	leukocyte mediated immunity
GO:0010713	3.893e-02	0.05236	2 CST3, IL6	2	negative regulation of collagen metabolic process
GO:0044252	3.893e-02	0.05236	2 CST3, IL6	2	negative regulation of multicellular organismal metabolic process
GO:0030334	4.027e-02	1.963	8 HBEGF, HMOX1, ICAM1, IGFBP5, IL6, PDGFA, TRIB1, VEGFA	75	regulation of cell migration
GO:0065008	4.190e-02	17.09	31 AGRN, BBS1, BMPR2, CCL2, CD55, CDC42SE1, DGKD, DNASE2, ERAP1, ERAP2, F10, FURIN, GAA, HMOX1, IDUA, IGFBP5, IGFBP7, IL11, IL6, LIF, NPC2, P2RX4, PDGFA, PLAUR, PROS1, SRF, TBX3, TGM2, TPP1, VEGFA, VEGFB	653	regulation of biological quality
GO:0046649	4.380e-02	3.011	10 CBFB, DPP4, ICAM1, IL11, IL23A, IL6, IL6ST, SHB, SOX4, TPD52	115	lymphocyte activation
GO:0002687	4.656e-02	0.2094	3 ICAM1, IL6, VEGFA	8	positive regulation of leukocyte migration
GO:0014812	4.656e-02	0.2094	3 IGFBP5, PDGFA, TRIB1	8	muscle cell migration
GO:0018212	4.730e-02	1.152	6 IL11, IL6, IL6ST, LIF, PDGFD, TPST1	44	peptidyl-tyrosine modification
GO:0045595	4.912e-02	4.791	13 AGRN, BMPR2, CLU, IL6, IL6ST, JUND, LIF, NFKB1, PPARD, RUNX1, SRF, TBX3, WWTR1	183	regulation of cell differentiation

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005576	1.058e-12	17.66	55 AGRN, ANGPTL4, C1R, C1S, CCL2, CFHR1, CLU, COL15A1, CPZ, CREG1, CST3, DCN, DPP4, ECM1, ERAP1, F10, FGF7, FURIN, GPX3, GRN, HBEGF, HLA-C, HMOX1, ICAM1, IGFBP5, IGFBP7, IL11, IL1RAP, IL23A, IL6, IL6ST, IL8, LGALS3BP, LIF, MFAP4, NID1, NPC2, OLFML2A, PDGFA, PDGFD, PLAUR, PROS1, PTGDS, SCG2, SERPINB2, SFRP1, ST3GAL1, SULF1, SVEP1, TCTN1, TNFAIP2, TNFRSF11B, TNFSF4, VEGFA, VEGFB	700	extracellular region
GO:0044421	1.237e-08	9.763	34 AGRN, ANGPTL4, CCL2, CFHR1, CLU, COL15A1, CPZ, CST3, DCN, ECM1, FURIN, GPX3, GRN, HBEGF, HMOX1, ICAM1, IGFBP5, IL11, IL23A, IL6, IL8, LGALS3BP, LIF, MFAP4, NID1, OLFML2A, PDGFA, SCG2, SFRP1, SULF1, TNFAIP2, TNFRSF11B, TNFSF4, VEGFA	387	extracellular region part
GO:0005615	1.998e-07	6.206	25 ANGPTL4, CCL2, CFHR1, CLU, CST3, FURIN, GPX3, GRN, HBEGF, HMOX1, ICAM1, IGFBP5, IL11, IL23A, IL6, IL8, LGALS3BP, LIF, PDGFA, SCG2, SFRP1, SULF1, TNFAIP2, TNFSF4, VEGFA	246	extracellular space
GO:0042612	1.019e-03	0.3784	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	15	MHC class I protein complex
GO:0009986	3.588e-03	3.28	12 AGRN, BMPR2, DPP4, FURIN, HBEGF, ICAM1, IL6ST, ITGA1, PDGFA, PLAUR, SULF1, VEGFA	130	cell surface
GO:0042611	5.911e-03	0.555	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	22	MHC protein complex
GO:0031012	2.502e-02	4.188	12 AGRN, ANGPTL4, COL15A1, CPZ, DCN, ECM1, LGALS3BP, MFAP4, NID1, OLFML2A, TNFRSF11B, VEGFA	166	extracellular matrix
GO:0005896	4.246e-02	0.07568	2 IL6, IL6ST	3	interleukin-6 receptor complex
GO:0005578	4.331e-02	3.935	11 AGRN, ANGPTL4, COL15A1, CPZ, DCN, ECM1, LGALS3BP, MFAP4, NID1, TNFRSF11B, VEGFA	156	proteinaceous extracellular matrix
GO:0000323	4.513e-02	2.825	9 DNASE2, DRAM, GAA, IDUA, LITAF, MAN2B1, MANBA, NPC2, TPP1	112	lytic vacuole
GO:0005764	4.513e-02	2.825	9 DNASE2, DRAM, GAA, IDUA, LITAF, MAN2B1, MANBA, NPC2, TPP1	112	lysosome

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005125	7.870e-05	1.784	12 CCL2, GRN, IL11, IL23A, IL6, IL8, LIF, NAMPT, SCG2, TNFRSF11B, TNFSF4, VEGFA	73	cytokine activity
GO:0032393	3.163e-04	0.22	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	9	MHC class I receptor activity
GO:0004871	2.928e-03	19.51	39 ADRA2A, AGRN, BMPR2, CCL2, ECM1, EPHA2, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL1RAP, IL6ST, ITGA1, LGALS3BP, LITAF, LTBR, LYN, NR4A3, NRXN3, P2RX4, PLAUR, PLK3, PPARD, RAMP1, RGS2, SCARB1, SH3BGRL, SHB, SLC20A2, TM2D1, TNFRSF11B, TP53BP2, TRAF3	798	signal transducer activity
GO:0060089	2.928e-03	19.51	39 ADRA2A, AGRN, BMPR2, CCL2, ECM1, EPHA2, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL1RAP, IL6ST, ITGA1, LGALS3BP, LITAF, LTBR, LYN, NR4A3, NRXN3, P2RX4, PLAUR, PLK3, PPARD, RAMP1, RGS2, SCARB1, SH3BGRL, SHB, SLC20A2, TM2D1, TNFRSF11B, TP53BP2, TRAF3	798	molecular transducer activity
GO:0008083	3.003e-03	2.298	11 ERAP1, FGF7, GRN, HBEGF, IL11, IL6, LIF, PDGFA, PDGFD, VEGFA, VEGFB	94	growth factor activity
GO:0005102	3.211e-03	9.973	25 ANGPTL4, CCL2, ERAP1, FGF7, GPNMB, GRN, HBEGF, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, LIF, MFAP4, MTSS1, NAMPT, P2RX4, PDGFA, PDGFD, SCG2, TNFRSF11B, TNFSF4, VEGFA, VEGFB	408	receptor binding
GO:0004872	2.166e-02	13.03	27 ADRA2A, BMPR2, EPHA2, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, ICAM1, IL1RAP, IL6ST, ITGA1, LGALS3BP, LTBR, NR4A3, NRXN3, P2RX4, PLAUR, PPARD, RAMP1, SCARB1, SLC20A2, TM2D1, TNFRSF11B	533	receptor activity
GO:0050840	2.540e-02	0.1467	3 AGRN, OLFML2A, VEGFA	6	extracellular matrix binding
GO:0042803	2.546e-02	3.642	12 DGKD, DPP4, GPD1L, IL6ST, NFKB1, OLFML2A, P2RX4, PDGFA, SRF, TPD52, VEGFA, WWTR1	149	protein homodimerization activity
GO:0004252	3.027e-02	1.344	7 C1R, C1S, DPP4, F10, FURIN, SERPINB2, TPP1	55	serine-type endopeptidase activity
GO:0046983	4.757e-02	6.429	16 DGKD, DPP4, FOSB, GPD1L, IL6ST, JUND, NFIL3, NFKB1, OLFML2A, P2RX4, PDGFA, POLR1C, SRF, TPD52, VEGFA, WWTR1	263	protein dimerization activity

Id	Pvalue	ExpCount	Count	Size	Term
04060	4.658e-04	3.759	15 BMPR2, CCL2, IL11, IL1RAP, IL23A, IL6, IL6ST, IL8, LIF, LTBR, PDGFA, TNFRSF11B, TNFSF4, VEGFA, VEGFB	122	Cytokine-cytokine receptor interaction
05332	3.169e-03	0.6471	6 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, IL6	21	Graft-versus-host disease
05330	2.380e-02	0.6471	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	21	Allograft rejection
05320	2.844e-02	0.6779	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	22	Autoimmune thyroid disease
04610	3.113e-02	1.048	6 C1R, C1S, CD55, F10, PLAUR, PROS1	34	Complement and coagulation cascades

No enriched terms

No enriched terms

Entrez genes

ABHD4abhydrolase domain containing 4 (218581_at), score: 0.33 ABLIM3actin binding LIM protein family, member 3 (205730_s_at), score: 0.35 ADRA2Aadrenergic, alpha-2A-, receptor (209869_at), score: 0.39 AGRNagrin (217419_x_at), score: 0.31 ANGPTL4angiopoietin-like 4 (221009_s_at), score: 0.57 ANK2ankyrin 2, neuronal (202920_at), score: 0.34 ARID5AAT rich interactive domain 5A (MRF1-like) (213138_at), score: 0.45 BBS1Bardet-Biedl syndrome 1 (218471_s_at), score: 0.32 BCL7AB-cell CLL/lymphoma 7A (203795_s_at), score: 0.38 BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) (210214_s_at), score: 0.4 BTN3A1butyrophilin, subfamily 3, member A1 (209770_at), score: 0.31 C19orf28chromosome 19 open reading frame 28 (220178_at), score: 0.45 C1Rcomplement component 1, r subcomponent (212067_s_at), score: 0.52 C1Scomplement component 1, s subcomponent (208747_s_at), score: 0.42 C4orf18chromosome 4 open reading frame 18 (219872_at), score: 0.35 C9orf167chromosome 9 open reading frame 167 (219620_x_at), score: 0.45 CADPS2Ca++-dependent secretion activator 2 (219572_at), score: 0.41 CASP4caspase 4, apoptosis-related cysteine peptidase (209310_s_at), score: 0.42 CBFBcore-binding factor, beta subunit (206788_s_at), score: 0.34 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: 0.5 CD302CD302 molecule (203799_at), score: 0.32 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: 0.34 CDC42SE1CDC42 small effector 1 (218157_x_at), score: 0.39 CFHR1complement factor H-related 1 (215388_s_at), score: 0.32 CLIP3CAP-GLY domain containing linker protein 3 (212358_at), score: 0.36 CLUclusterin (208791_at), score: 0.33 COL15A1collagen, type XV, alpha 1 (203477_at), score: 0.73 CPZcarboxypeptidase Z (211062_s_at), score: 0.43 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: 0.56 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: 0.31 CST3cystatin C (201360_at), score: 0.48 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: 0.37 DCNdecorin (211896_s_at), score: 0.33 DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked (205000_at), score: 0.47 DESdesmin (202222_s_at), score: -1 DGKDdiacylglycerol kinase, delta 130kDa (208072_s_at), score: 0.51 DNASE2deoxyribonuclease II, lysosomal (214992_s_at), score: 0.41 DOCK9dedicator of cytokinesis 9 (212538_at), score: 0.38 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: 0.47 DRAMdamage-regulated autophagy modulator (218627_at), score: 0.34 DUSP3dual specificity phosphatase 3 (201537_s_at), score: 0.34 ECM1extracellular matrix protein 1 (209365_s_at), score: 0.37 EFHD1EF-hand domain family, member D1 (209343_at), score: 0.34 EGR3early growth response 3 (206115_at), score: 0.44 EIF1AYeukaryotic translation initiation factor 1A, Y-linked (204409_s_at), score: 0.38 EPHA2EPH receptor A2 (203499_at), score: 0.35 ERAP1endoplasmic reticulum aminopeptidase 1 (214012_at), score: 0.45 ERAP2endoplasmic reticulum aminopeptidase 2 (219759_at), score: 0.32 F10coagulation factor X (205620_at), score: 0.39 FADS3fatty acid desaturase 3 (216080_s_at), score: 0.33 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: 0.41 FHOD1formin homology 2 domain containing 1 (218530_at), score: 0.48 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: 0.5 FURINfurin (paired basic amino acid cleaving enzyme) (201945_at), score: 0.34 GAAglucosidase, alpha; acid (202812_at), score: 0.32 GALNT3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (203397_s_at), score: 0.4 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: 0.49 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: 0.41 GPD1Lglycerol-3-phosphate dehydrogenase 1-like (212510_at), score: 0.3 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: 0.64 GPR183G protein-coupled receptor 183 (205419_at), score: 0.35 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: 0.37 GPX3glutathione peroxidase 3 (plasma) (214091_s_at), score: 0.36 GRAMD3GRAM domain containing 3 (218706_s_at), score: 0.34 GRNgranulin (211284_s_at), score: 0.43 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: 0.34 GSTT1glutathione S-transferase theta 1 (203815_at), score: 0.31 H2BFSH2B histone family, member S (208579_x_at), score: 0.33 HBEGFheparin-binding EGF-like growth factor (203821_at), score: 0.55 HHEXhematopoietically expressed homeobox (215933_s_at), score: 0.5 HIPK3homeodomain interacting protein kinase 3 (210148_at), score: 0.34 HIST1H2AChistone cluster 1, H2ac (215071_s_at), score: 0.41 HIST1H2BKhistone cluster 1, H2bk (209806_at), score: 0.35 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: 0.33 HLA-Amajor histocompatibility complex, class I, A (217436_x_at), score: 0.48 HLA-Bmajor histocompatibility complex, class I, B (211911_x_at), score: 0.42 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: 0.62 HLA-Emajor histocompatibility complex, class I, E (200904_at), score: 0.62 HLA-Fmajor histocompatibility complex, class I, F (204806_x_at), score: 0.58 HMOX1heme oxygenase (decycling) 1 (203665_at), score: 0.38 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: 0.42 IDUAiduronidase, alpha-L- (205059_s_at), score: 0.39 IGFBP5insulin-like growth factor binding protein 5 (203424_s_at), score: 0.33 IGFBP7insulin-like growth factor binding protein 7 (201162_at), score: 0.37 IL11interleukin 11 (206924_at), score: 0.4 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: 0.51 IL23Ainterleukin 23, alpha subunit p19 (211796_s_at), score: 0.43 IL6interleukin 6 (interferon, beta 2) (205207_at), score: 0.6 IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor) (204864_s_at), score: 0.4 IL8interleukin 8 (202859_x_at), score: 0.36 ITGA1integrin, alpha 1 (214660_at), score: 0.34 JARID1Djumonji, AT rich interactive domain 1D (206700_s_at), score: 0.37 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: 0.31 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: 0.41 JUNDjun D proto-oncogene (203751_x_at), score: 0.42 KHDRBS3KH domain containing, RNA binding, signal transduction associated 3 (209781_s_at), score: 0.31 KIAA0247KIAA0247 (202181_at), score: 0.39 KLHL21kelch-like 21 (Drosophila) (203068_at), score: 0.4 KLHL26kelch-like 26 (Drosophila) (219354_at), score: 0.34 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: 0.39 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: 0.51 LITAFlipopolysaccharide-induced TNF factor (200706_s_at), score: 0.41 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: 0.38 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.48 LOC100128809similar to hCG2045829 (215707_s_at), score: 0.38 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: 0.33 LTBRlymphotoxin beta receptor (TNFR superfamily, member 3) (203005_at), score: 0.35 LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog (202625_at), score: 0.35 MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (209348_s_at), score: 0.34 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: 0.45 MAN2B1mannosidase, alpha, class 2B, member 1 (209166_s_at), score: 0.35 MANBAmannosidase, beta A, lysosomal (203778_at), score: 0.38 MAP1Smicrotubule-associated protein 1S (218522_s_at), score: 0.39 MAP3K7IP2mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (210284_s_at), score: 0.31 MEIS1Meis homeobox 1 (204069_at), score: 0.38 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: 0.5 MFAP4microfibrillar-associated protein 4 (212713_at), score: 0.44 MTSS1metastasis suppressor 1 (203037_s_at), score: 0.48 NAB1NGFI-A binding protein 1 (EGR1 binding protein 1) (208047_s_at), score: 0.35 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: 0.37 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: 0.5 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: 0.35 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: 0.55 NID1nidogen 1 (202008_s_at), score: 0.49 NINJ1ninjurin 1 (203045_at), score: 0.52 NPC2Niemann-Pick disease, type C2 (200701_at), score: 0.41 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: 0.44 NRXN3neurexin 3 (205795_at), score: 0.35 OLFML2Aolfactomedin-like 2A (213075_at), score: 0.38 OS9osteosarcoma amplified 9, endoplasmic reticulum associated protein (200714_x_at), score: 0.43 P2RX4purinergic receptor P2X, ligand-gated ion channel, 4 (204088_at), score: 0.35 PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (203557_s_at), score: 0.33 PCDH7protocadherin 7 (205534_at), score: 0.37 PCDHG@protocadherin gamma cluster (215836_s_at), score: 0.35 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: 0.52 PDGFDplatelet derived growth factor D (219304_s_at), score: 0.37 PDLIM3PDZ and LIM domain 3 (209621_s_at), score: 0.45 PIGBphosphatidylinositol glycan anchor biosynthesis, class B (214151_s_at), score: 0.37 PKP2plakophilin 2 (207717_s_at), score: 0.55 PLAURplasminogen activator, urokinase receptor (211924_s_at), score: 0.32 PLK3polo-like kinase 3 (Drosophila) (204958_at), score: 0.31 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: 0.59 POLR1Cpolymerase (RNA) I polypeptide C, 30kDa (207515_s_at), score: 0.32 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: 0.39 PROS1protein S (alpha) (207808_s_at), score: 0.32 PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) (204279_at), score: 0.31 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: 0.54 RAMP1receptor (G protein-coupled) activity modifying protein 1 (204916_at), score: 0.34 RANBP2RAN binding protein 2 (201711_x_at), score: 0.32 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: 0.36 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: 0.51 RNF130ring finger protein 130 (217865_at), score: 0.31 RPS28P6ribosomal protein S28 pseudogene 6 (216380_x_at), score: 0.35 RPS4Y1ribosomal protein S4, Y-linked 1 (201909_at), score: 0.55 RRADRas-related associated with diabetes (204803_s_at), score: 0.61 RTN1reticulon 1 (203485_at), score: 0.31 RUNX1runt-related transcription factor 1 (209360_s_at), score: 0.45 SAT1spermidine/spermine N1-acetyltransferase 1 (213988_s_at), score: 0.35 SCARB1scavenger receptor class B, member 1 (201819_at), score: 0.46 SCG2secretogranin II (chromogranin C) (204035_at), score: 0.46 SENP5SUMO1/sentrin specific peptidase 5 (213184_at), score: 0.36 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: 0.42 SETXsenataxin (201964_at), score: 0.38 SFRP1secreted frizzled-related protein 1 (202036_s_at), score: 0.35 SFRS2Bsplicing factor, arginine/serine-rich 2B (213152_s_at), score: 0.31 SH3BGRLSH3 domain binding glutamic acid-rich protein like (201311_s_at), score: 0.35 SHBSrc homology 2 domain containing adaptor protein B (204657_s_at), score: 0.34 SLC10A3solute carrier family 10 (sodium/bile acid cotransporter family), member 3 (204928_s_at), score: 0.32 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: 0.41 SLC20A2solute carrier family 20 (phosphate transporter), member 2 (202744_at), score: 0.31 SMOXspermine oxidase (210357_s_at), score: 0.42 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: 0.43 SPATA20spermatogenesis associated 20 (218164_at), score: 0.33 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: 0.47 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: 0.45 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: 0.52 SQLEsqualene epoxidase (213562_s_at), score: 0.36 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: 0.38 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: 0.33 STBD1starch binding domain 1 (203986_at), score: 0.34 STK38Lserine/threonine kinase 38 like (212572_at), score: 0.43 STOMstomatin (201060_x_at), score: 0.36 SULF1sulfatase 1 (212353_at), score: 0.36 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: 0.42 TBX3T-box 3 (219682_s_at), score: 0.33 TCTN1tectonic family member 1 (218584_at), score: 0.33 TEX2testis expressed 2 (218099_at), score: 0.46 TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) (201042_at), score: 0.41 TM2D1TM2 domain containing 1 (211703_s_at), score: 0.39 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: 0.5 TMEM39Atransmembrane protein 39A (218615_s_at), score: 0.41 TMEM41Btransmembrane protein 41B (212623_at), score: 0.54 TNFAIP2tumor necrosis factor, alpha-induced protein 2 (202510_s_at), score: 0.48 TNFRSF11Btumor necrosis factor receptor superfamily, member 11b (204933_s_at), score: 0.34 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: 0.52 TNS3tensin 3 (217853_at), score: 0.36 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: 0.34 TP53I11tumor protein p53 inducible protein 11 (214667_s_at), score: 0.49 TPD52tumor protein D52 (201690_s_at), score: 0.43 TPP1tripeptidyl peptidase I (200742_s_at), score: 0.68 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: 0.39 TRAF3TNF receptor-associated factor 3 (221571_at), score: 0.34 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: 0.59 TRIM22tripartite motif-containing 22 (213293_s_at), score: 0.36 UBA7ubiquitin-like modifier activating enzyme 7 (203281_s_at), score: 0.31 UBE3Bubiquitin protein ligase E3B (212403_at), score: 0.36 VEGFAvascular endothelial growth factor A (211527_x_at), score: 0.47 VEGFBvascular endothelial growth factor B (203683_s_at), score: 0.39 WT1Wilms tumor 1 (206067_s_at), score: 0.37 WWTR1WW domain containing transcription regulator 1 (202132_at), score: 0.39 YRDCyrdC domain containing (E. coli) (218647_s_at), score: 0.44 ZNF282zinc finger protein 282 (212892_at), score: 0.38 ZNF35zinc finger protein 35 (206096_at), score: 0.49 ZNF672zinc finger protein 672 (218068_s_at), score: 0.33

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
1Twin.CEL	1	2	DS-twin	hgu133plus2	Down	DS-twin 1
6Twin.CEL	6	2	DS-twin	hgu133plus2	none	DS-twin 6
5CTwin.CEL	5	2	DS-twin	hgu133plus2	Down	DS-twin 5
2Twin.CEL	2	2	DS-twin	hgu133plus2	none	DS-twin 2
E-GEOD-3407-raw-cel-1437949557.cel	1	4	Cockayne	hgu133a	CS	eGFP
46A.CEL	1	3	DS-mosaic	hgu133plus2	none	DS-mosaic 1