Under-expression is coded with green,
over-expression with red color.
DNA replication
The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.
chromosome segregation
The process by which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets.
chromosome organization
A process that is carried out at the cellular level that results in the formation, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information.
mitotic sister chromatid segregation
The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
cell cycle checkpoint
The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage.
S phase of mitotic cell cycle
A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place.
M phase of mitotic cell cycle
A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.
mitotic cell cycle
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
M phase
A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division.
nuclear division
A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.
sister chromatid segregation
The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
blood vessel development
The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
cell activation
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
regulation of protein amino acid phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
positive regulation of protein amino acid phosphorylation
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
vasculature development
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.
immune system process
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
generation of a signal involved in cell-cell signaling
The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.
regulation of cell cycle
Any process that modulates the rate or extent of progression through the cell cycle.
defense response
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
secretion
The controlled release of a substance by a cell, a group of cells, or a tissue.
cellular alcohol metabolic process
The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
DNA metabolic process
The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
DNA-dependent DNA replication
The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.
DNA replication initiation
The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
DNA strand elongation during DNA replication
The process by which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.
regulation of DNA replication
Any process that modulates the frequency, rate or extent of DNA replication.
protein modification process
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
protein amino acid phosphorylation
The process of introducing a phosphate group on to a protein.
lipid metabolic process
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
phosphorus metabolic process
The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).
phosphate metabolic process
The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism.
cell motion
Any process involved in the controlled movement of a cell.
chemotaxis
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
response to stress
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
organelle organization
A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
cell cycle
The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
mitosis
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
regulation of mitosis
Any process that modulates the frequency, rate or extent of mitosis.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of mitotic cell cycle
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
behavior
The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
locomotory behavior
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
steroid metabolic process
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
cell proliferation
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
positive regulation of cell proliferation
Any process that activates or increases the rate or extent of cell proliferation.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
response to external stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
regulation of biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
positive regulation of metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
hormone transport
The directed movement of hormones into, out of, within or between cells.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
positive regulation of phosphorus metabolic process
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
regulation of cell cycle process
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
positive regulation of macromolecule metabolic process
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of cell communication
Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
regulation of hormone levels
Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.
cellular component organization
A process that is carried out at the cellular level which results in the formation, arrangement of constituent parts, or disassembly of a cellular component.
sterol metabolic process
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
phosphorylation
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
cell migration
The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of phosphate metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
cell cycle process
A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
cell cycle phase
A cell cycle process comprising the steps by which a cell progresses through one of the biochemical and morphological phases and events that occur during successive cell replication or nuclear replication events.
DNA strand elongation
The DNA metabolic process by which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand.
cell differentiation
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.
respiratory tube development
The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.
lung development
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
regulation of cell migration
Any process that modulates the frequency, rate or extent of cell migration.
leukocyte chemotaxis
The movement of a leukocyte in response to an external stimulus.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
positive regulation of cellular metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
regulation of protein modification process
Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
positive regulation of protein modification process
Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
regulation of cellular protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
positive regulation of cellular protein metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
regulation of localization
Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
cellular biopolymer metabolic process
The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
cellular biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
tube development
The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
locomotion
Self-propelled movement of a cell or organism from one location to another.
regulation of locomotion
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
regulation of cell proliferation
Any process that modulates the frequency, rate or extent of cell proliferation.
response to chemical stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.
regulation of phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
positive regulation of phosphorylation
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
taxis
The directed movement of a motile cell or organism in response to an external stimulus.
macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biopolymer metabolic process
The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.
biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.
biopolymer modification
The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer, resulting in a change in its properties.
post-translational protein modification
The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
cellular protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.
positive regulation of cell cycle
Any process that activates or increases the rate or extent of progression through the cell cycle.
positive regulation of mitosis
Any process that activates or increases the frequency, rate or extent of mitosis.
positive regulation of phosphate metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
hormone secretion
The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
regulation of hormone secretion
Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells.
negative regulation of hormone secretion
Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells.
organelle fission
The creation of two or more organelles by division of one organelle.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of biological process
Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of cellular process
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
cell motility
Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
leukocyte migration
The movement of leukocytes within or between different tissues and organs of the body.
regulation of secretion
Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.
negative regulation of secretion
Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.
regulation of transport
Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
negative regulation of transport
Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
regulation of DNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.
regulation of phosphorus metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
localization
Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
regulation of protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
positive regulation of protein metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
regulation of cell motion
Any process that modulates the frequency, rate or extent of the movement of a cell.
positive regulation of cell motion
Any process that activates or increases the frequency, rate or extent of the movement of a cell.
cell division
The process resulting in the physical partitioning and separation of a cell into daughter cells.
S phase
A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.
interphase
A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of chromosome segregation. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.
interphase of mitotic cell cycle
A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.
localization of cell
Any process by which a cell is transported to, and/or maintained in, a specific location.
regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
cell chemotaxis
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
all
This term is the most general term possible
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
positive regulation of metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of cellular process
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
regulation of locomotion
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of biological process
Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of localization
Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
positive regulation of metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
positive regulation of macromolecule metabolic process
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
positive regulation of cellular metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
The chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
cell motility
Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.
cell cycle process
A cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
sister chromatid segregation
The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.
positive regulation of cell proliferation
Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cellular metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
positive regulation of cell cycle
Any process that activates or increases the rate or extent of progression through the cell cycle.
positive regulation of cell motion
Any process that activates or increases the frequency, rate or extent of the movement of a cell.
regulation of cell cycle
Any process that modulates the rate or extent of progression through the cell cycle.
regulation of cell communication
Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cell proliferation
Any process that modulates the frequency, rate or extent of cell proliferation.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of cellular process
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of cell motion
Any process that modulates the frequency, rate or extent of the movement of a cell.
tube development
The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
regulation of cell motion
Any process that modulates the frequency, rate or extent of the movement of a cell.
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
taxis
The directed movement of a motile cell or organism in response to an external stimulus.
chemotaxis
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
cell motion
Any process involved in the controlled movement of a cell.
regulation of transport
Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
negative regulation of transport
Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
positive regulation of cellular metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
regulation of macromolecule biosynthetic process
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
positive regulation of macromolecule metabolic process
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature e.g. polysaccharides and proteins.
cellular macromolecule biosynthetic process
The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells.
cellular biopolymer metabolic process
The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
positive regulation of phosphorus metabolic process
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
regulation of phosphorus metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
steroid metabolic process
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
cellular lipid metabolic process
The chemical reactions and pathways involving lipids, as carried out by individual cells.
regulation of protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
positive regulation of protein metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
negative regulation of hormone secretion
Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells.
regulation of cell migration
Any process that modulates the frequency, rate or extent of cell migration.
positive regulation of cell motion
Any process that activates or increases the frequency, rate or extent of the movement of a cell.
regulation of mitotic cell cycle
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
regulation of cell cycle process
Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
positive regulation of cell cycle
Any process that activates or increases the rate or extent of progression through the cell cycle.
generation of a signal involved in cell-cell signaling
The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.
regulation of hormone secretion
Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells.
positive regulation of cell proliferation
Any process that activates or increases the rate or extent of cell proliferation.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
tissue development
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
respiratory tube development
The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.
cell chemotaxis
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
regulation of cell migration
Any process that modulates the frequency, rate or extent of cell migration.
leukocyte migration
The movement of leukocytes within or between different tissues and organs of the body.
leukocyte chemotaxis
The movement of a leukocyte in response to an external stimulus.
negative regulation of hormone secretion
Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells.
negative regulation of transport
Any process that stops, prevents or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
taxis
The directed movement of a motile cell or organism in response to an external stimulus.
hormone secretion
The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
regulation of secretion
Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.
negative regulation of secretion
Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.
hormone secretion
The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells.
hormone transport
The directed movement of hormones into, out of, within or between cells.
cellular biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
regulation of DNA replication
Any process that modulates the frequency, rate or extent of DNA replication.
sterol metabolic process
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
positive regulation of cellular protein metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
regulation of DNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.
positive regulation of cellular protein metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
positive regulation of phosphorus metabolic process
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
regulation of DNA replication
Any process that modulates the frequency, rate or extent of DNA replication.
regulation of cellular protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
positive regulation of protein metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.
DNA metabolic process
The chemical reactions and pathways involving DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides.
cellular biopolymer biosynthetic process
The chemical reactions and pathways resulting in the formation of biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.
cellular protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.
regulation of DNA metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA.
regulation of phosphate metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
positive regulation of phosphate metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
protein modification process
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
regulation of cellular protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
positive regulation of cellular protein metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
negative regulation of hormone secretion
Any process that stops, prevents or reduces the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells.
mitosis
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
regulation of mitosis
Any process that modulates the frequency, rate or extent of mitosis.
sister chromatid segregation
The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets.
positive regulation of mitosis
Any process that activates or increases the frequency, rate or extent of mitosis.
M phase of mitotic cell cycle
A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place.
mitotic sister chromatid segregation
The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
regulation of mitosis
Any process that modulates the frequency, rate or extent of mitosis.
positive regulation of mitosis
Any process that activates or increases the frequency, rate or extent of mitosis.
S phase of mitotic cell cycle
A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place.
S phase
A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the cell cycle during which DNA synthesis takes place.
interphase of mitotic cell cycle
A cell cycle process comprising the steps by which a cell progresses through interphase, the stage of cell cycle between successive rounds of mitosis. Canonically, interphase is the stage of the cell cycle during which the biochemical and physiologic functions of the cell are performed and replication of chromatin occurs.
lung development
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
regulation of hormone secretion
Any process that modulates the frequency, rate or extent of the regulated release of a hormone from a cell or group of cells.
negative regulation of secretion
Any process that stops, prevents or reduces the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.
DNA replication
The process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA.
positive regulation of protein modification process
Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
positive regulation of phosphate metabolic process
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
regulation of protein modification process
Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
positive regulation of protein modification process
Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
regulation of DNA replication
Any process that modulates the frequency, rate or extent of DNA replication.
regulation of phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
positive regulation of phosphorylation
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
mitosis
A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell.
positive regulation of protein amino acid phosphorylation
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of protein amino acid phosphorylation
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
regulation of protein amino acid phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
positive regulation of phosphorylation
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
protein amino acid phosphorylation
The process of introducing a phosphate group on to a protein.
DNA replication initiation
The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action.
DNA strand elongation during DNA replication
The process by which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.
regulation of protein amino acid phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
positive regulation of protein amino acid phosphorylation
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
nuclear chromosome
A chromosome found in the nucleus of a eukaryotic cell.
condensed chromosome
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
chromosome, centromeric region
The region of a chromosome that includes the centromere and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
kinetochore
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
condensed chromosome kinetochore
A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.
condensed chromosome, centromeric region
The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
nucleus
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
replication fork
The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
alpha DNA polymerase:primase complex
A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
chromosome
A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
spindle
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
microtubule cytoskeleton
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
replisome
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
membrane-enclosed lumen
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
nuclear lumen
The volume enclosed by the nuclear inner membrane.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
protein-DNA complex
A macromolecular complex containing both protein and DNA molecules.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.
nuclear replication fork
The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
nuclear replisome
A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
chromosomal part
Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
nuclear part
Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
nuclear chromosome part
Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
intracellular organelle lumen
An organelle lumen that is part of an intracellular organelle.
all
This term is the most general term possible
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
intracellular organelle lumen
An organelle lumen that is part of an intracellular organelle.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
kinetochore
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
kinetochore
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
replisome
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
nuclear lumen
The volume enclosed by the nuclear inner membrane.
nuclear chromosome part
Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.
spindle
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
alpha DNA polymerase:primase complex
A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
nuclear part
Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.
nuclear chromosome
A chromosome found in the nucleus of a eukaryotic cell.
chromosomal part
Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
kinetochore
A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
replisome
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
alpha DNA polymerase:primase complex
A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis.
nuclear replication fork
The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
nuclear replisome
A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
nuclear chromosome part
Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.
condensed chromosome, centromeric region
The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
spindle
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
condensed chromosome kinetochore
A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.
nuclear replisome
A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.
protein binding
Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
nucleic acid binding
Interacting selectively with any nucleic acid.
DNA binding
Interacting selectively with DNA (deoxyribonucleic acid).
receptor binding
Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
cytokine activity
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
binding
The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
growth factor activity
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
all
This term is the most general term possible
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 03030 | 1.552e-07 | 1.828 | 14 | 33 | DNA replication |
| 04110 | 3.967e-05 | 5.428 | 20 | 98 | Cell cycle |
| 04060 | 1.026e-03 | 6.758 | 20 | 122 | Cytokine-cytokine receptor interaction |
ABCA5ATP-binding cassette, sub-family A (ABC1), member 5 (213353_at), score: -0.55 ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (209612_s_at), score: -0.44 ADIPOR2adiponectin receptor 2 (201346_at), score: -0.5 AJAP1adherens junctions associated protein 1 (206460_at), score: -0.46 ALDH6A1aldehyde dehydrogenase 6 family, member A1 (221589_s_at), score: -0.44 ANGPTL2angiopoietin-like 2 (213001_at), score: -0.44 ANGPTL4angiopoietin-like 4 (221009_s_at), score: -1 ANK2ankyrin 2, neuronal (202920_at), score: -0.62 AQP3aquaporin 3 (Gill blood group) (39248_at), score: -0.65 AREGamphiregulin (205239_at), score: -0.67 ARHGAP5Rho GTPase activating protein 5 (217936_at), score: -0.45 ARID5AAT rich interactive domain 5A (MRF1-like) (213138_at), score: -0.44 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: -0.6 ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila) (219918_s_at), score: 0.77 ATF3activating transcription factor 3 (202672_s_at), score: -0.51 ATP13A3ATPase type 13A3 (219558_at), score: -0.67 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (212361_s_at), score: -0.44 AURKBaurora kinase B (209464_at), score: 0.82 B3GNT2UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (219326_s_at), score: -0.81 BCL7AB-cell CLL/lymphoma 7A (203795_s_at), score: -0.43 BHLHE40basic helix-loop-helix family, member e40 (201170_s_at), score: -0.49 BIRC5baculoviral IAP repeat-containing 5 (202095_s_at), score: 0.81 BLMBloom syndrome (205733_at), score: 0.78 BMP2bone morphogenetic protein 2 (205289_at), score: -0.86 BMP6bone morphogenetic protein 6 (206176_at), score: -0.63 BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) (210214_s_at), score: -0.56 BNC1basonuclin 1 (206581_at), score: -0.49 BRCA2breast cancer 2, early onset (208368_s_at), score: 0.78 BUB1budding uninhibited by benzimidazoles 1 homolog (yeast) (209642_at), score: 0.78 BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast) (203755_at), score: 0.77 C17orf91chromosome 17 open reading frame 91 (214696_at), score: -0.83 C18orf24chromosome 18 open reading frame 24 (217640_x_at), score: 0.79 C1orf56chromosome 1 open reading frame 56 (221222_s_at), score: -0.52 C1Rcomplement component 1, r subcomponent (212067_s_at), score: -0.5 C20orf27chromosome 20 open reading frame 27 (50314_i_at), score: 0.77 C21orf45chromosome 21 open reading frame 45 (219004_s_at), score: 0.87 C3orf52chromosome 3 open reading frame 52 (219474_at), score: -0.47 C4orf18chromosome 4 open reading frame 18 (219872_at), score: -0.5 C6orf145chromosome 6 open reading frame 145 (212923_s_at), score: -0.55 CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b (209682_at), score: -0.55 CBR3carbonyl reductase 3 (205379_at), score: 0.78 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: -0.59 CCL7chemokine (C-C motif) ligand 7 (208075_s_at), score: -0.52 CCNB2cyclin B2 (202705_at), score: 0.77 CCNE2cyclin E2 (205034_at), score: 0.78 CCNJcyclin J (219470_x_at), score: -0.54 CD302CD302 molecule (203799_at), score: -0.54 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: -0.53 CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae) (208022_s_at), score: -0.45 CDC20cell division cycle 20 homolog (S. cerevisiae) (202870_s_at), score: 0.79 CDC45LCDC45 cell division cycle 45-like (S. cerevisiae) (204126_s_at), score: 0.77 CDC6cell division cycle 6 homolog (S. cerevisiae) (203967_at), score: 0.8 CDC7cell division cycle 7 homolog (S. cerevisiae) (204510_at), score: 0.78 CDCA8cell division cycle associated 8 (221520_s_at), score: 0.77 CDK2cyclin-dependent kinase 2 (204252_at), score: 0.82 CDT1chromatin licensing and DNA replication factor 1 (209832_s_at), score: 0.8 CDYLchromodomain protein, Y-like (203100_s_at), score: -0.56 CENPFcentromere protein F, 350/400ka (mitosin) (207828_s_at), score: 0.76 CENPMcentromere protein M (218741_at), score: 0.84 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: 0.83 CHAF1Bchromatin assembly factor 1, subunit B (p60) (204775_at), score: 0.8 CHMP1Bchromatin modifying protein 1B (218178_s_at), score: -0.56 CHST2carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (203921_at), score: -0.45 CKAP2cytoskeleton associated protein 2 (218252_at), score: 0.84 CLCF1cardiotrophin-like cytokine factor 1 (219500_at), score: -0.54 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: -0.63 COL15A1collagen, type XV, alpha 1 (203477_at), score: -0.64 CORINcorin, serine peptidase (220356_at), score: -0.54 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: -0.58 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: -0.5 CRISPLD2cysteine-rich secretory protein LCCL domain containing 2 (221541_at), score: -0.5 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: -0.51 CSRNP2cysteine-serine-rich nuclear protein 2 (221260_s_at), score: -0.44 CTSFcathepsin F (203657_s_at), score: -0.48 CTSOcathepsin O (203758_at), score: -0.42 CXCL3chemokine (C-X-C motif) ligand 3 (207850_at), score: -0.71 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: -0.71 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: -0.62 DACT1dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) (219179_at), score: -0.45 DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae) (218508_at), score: -0.48 DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 (CHL1-like helicase homolog, S. cerevisiae) (208149_x_at), score: 0.83 DDX12DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12 (CHL1-like helicase homolog, S. cerevisiae) (213378_s_at), score: 0.76 DEPDC1DEP domain containing 1 (220295_x_at), score: 0.81 DHCR77-dehydrocholesterol reductase (201790_s_at), score: -0.51 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: -0.61 DLEU2Ldeleted in lymphocytic leukemia 2-like (215629_s_at), score: 0.78 DLGAP5discs, large (Drosophila) homolog-associated protein 5 (203764_at), score: 0.77 DOCK9dedicator of cytokinesis 9 (212538_at), score: -0.49 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: -0.45 DRAMdamage-regulated autophagy modulator (218627_at), score: -0.48 DSCC1defective in sister chromatid cohesion 1 homolog (S. cerevisiae) (219000_s_at), score: 0.79 DSN1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae) (219512_at), score: 0.85 DTLdenticleless homolog (Drosophila) (218585_s_at), score: 0.8 DUSP5dual specificity phosphatase 5 (209457_at), score: -0.56 DVL3dishevelled, dsh homolog 3 (Drosophila) (201908_at), score: -0.42 ECM2extracellular matrix protein 2, female organ and adipocyte specific (206101_at), score: -0.5 EDN1endothelin 1 (218995_s_at), score: -0.48 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: -0.72 EGR3early growth response 3 (206115_at), score: -0.57 EIF2C2eukaryotic translation initiation factor 2C, 2 (213310_at), score: -0.43 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: -0.73 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (219650_at), score: 0.81 EREGepiregulin (205767_at), score: -0.45 EZH2enhancer of zeste homolog 2 (Drosophila) (203358_s_at), score: 0.81 F10coagulation factor X (205620_at), score: -0.5 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: -0.6 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: -0.6 FAM108B1family with sequence similarity 108, member B1 (220285_at), score: -0.54 FANCGFanconi anemia, complementation group G (203564_at), score: 0.81 FBXW7F-box and WD repeat domain containing 7 (218751_s_at), score: -0.64 FCGRTFc fragment of IgG, receptor, transporter, alpha (218831_s_at), score: -0.42 FEM1Bfem-1 homolog b (C. elegans) (212367_at), score: -0.6 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: -0.68 FGF2fibroblast growth factor 2 (basic) (204421_s_at), score: -0.42 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: -0.74 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: -0.88 FOXO3forkhead box O3 (204132_s_at), score: -0.49 FOXO3Bforkhead box O3B pseudogene (210655_s_at), score: -0.65 FRYfurry homolog (Drosophila) (204072_s_at), score: -0.56 FUT4fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) (209892_at), score: -0.44 GABARAPL1GABA(A) receptor-associated protein like 1 (208868_s_at), score: -0.62 GABARAPL3GABA(A) receptors associated protein like 3 (pseudogene) (211458_s_at), score: -0.52 GADD45Agrowth arrest and DNA-damage-inducible, alpha (203725_at), score: -0.51 GALNAC4S-6STB cell RAG associated protein (203066_at), score: -0.51 GALNT4UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4) (220442_at), score: -0.47 GCC2GRIP and coiled-coil domain containing 2 (202832_at), score: -0.43 GCH1GTP cyclohydrolase 1 (204224_s_at), score: -0.71 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: -0.81 GFPT2glutamine-fructose-6-phosphate transaminase 2 (205100_at), score: -0.69 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: 0.85 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: 0.87 GINS3GINS complex subunit 3 (Psf3 homolog) (45633_at), score: 0.83 GMNNgeminin, DNA replication inhibitor (218350_s_at), score: 0.81 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: -0.54 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: -0.55 GPR183G protein-coupled receptor 183 (205419_at), score: -0.73 GRAMD3GRAM domain containing 3 (218706_s_at), score: -0.45 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: -0.45 GTSE1G-2 and S-phase expressed 1 (204318_s_at), score: 0.78 HBEGFheparin-binding EGF-like growth factor (203821_at), score: -0.84 HIPK3homeodomain interacting protein kinase 3 (210148_at), score: -0.53 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: -0.69 HIVEP2human immunodeficiency virus type I enhancer binding protein 2 (212642_s_at), score: -0.71 HK2hexokinase 2 (202934_at), score: -0.67 HLXH2.0-like homeobox (214438_at), score: -0.6 HMGB2high-mobility group box 2 (208808_s_at), score: 0.86 HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) (221750_at), score: -0.51 HMMRhyaluronan-mediated motility receptor (RHAMM) (207165_at), score: 0.76 HMOX1heme oxygenase (decycling) 1 (203665_at), score: -0.55 HOXA10homeobox A10 (213150_at), score: 0.79 HSPA12Aheat shock 70kDa protein 12A (214434_at), score: -0.48 HSPB3heat shock 27kDa protein 3 (206375_s_at), score: -0.48 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: -0.62 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: -0.83 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: -0.69 IDI2isopentenyl-diphosphate delta isomerase 2 (217631_at), score: -0.57 IER3immediate early response 3 (201631_s_at), score: -0.44 IL11interleukin 11 (206924_at), score: -0.72 IL1Ainterleukin 1, alpha (210118_s_at), score: -0.54 IL1Binterleukin 1, beta (39402_at), score: -0.57 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: -0.52 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: -0.66 IL6interleukin 6 (interferon, beta 2) (205207_at), score: -0.92 IL8interleukin 8 (202859_x_at), score: -0.62 INHBAinhibin, beta A (210511_s_at), score: -0.48 INSIG1insulin induced gene 1 (201627_s_at), score: -0.8 IRGQimmunity-related GTPase family, Q (64488_at), score: -0.42 ITGA1integrin, alpha 1 (214660_at), score: -0.53 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: -0.68 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: -0.9 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: -0.83 JMJD6jumonji domain containing 6 (212722_s_at), score: -0.6 KCND3potassium voltage-gated channel, Shal-related subfamily, member 3 (213832_at), score: -0.42 KIAA0247KIAA0247 (202181_at), score: -0.59 KIAA0586KIAA0586 (205631_at), score: 0.84 KIAA1024KIAA1024 (215081_at), score: -0.53 KIAA1644KIAA1644 (52837_at), score: -0.73 KIF11kinesin family member 11 (204444_at), score: 0.8 KIF15kinesin family member 15 (219306_at), score: 0.78 KIF18Bkinesin family member 18B (222039_at), score: 0.84 KIF20Bkinesin family member 20B (205235_s_at), score: 0.76 KIF22kinesin family member 22 (202183_s_at), score: 0.81 KIF4Akinesin family member 4A (218355_at), score: 0.8 KLF7Kruppel-like factor 7 (ubiquitous) (204334_at), score: -0.47 KLHL21kelch-like 21 (Drosophila) (203068_at), score: -0.56 LAMC2laminin, gamma 2 (202267_at), score: -0.46 LBHlimb bud and heart development homolog (mouse) (221011_s_at), score: -0.43 LDLRlow density lipoprotein receptor (202068_s_at), score: -0.5 LHFPlipoma HMGIC fusion partner (218656_s_at), score: -0.52 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: -0.91 LIMS1LIM and senescent cell antigen-like domains 1 (207198_s_at), score: -0.42 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: -0.49 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: -0.84 LMNB1lamin B1 (203276_at), score: 0.81 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: -0.77 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: -0.56 LRRC2leucine rich repeat containing 2 (219949_at), score: -0.42 LRRFIP1leucine rich repeat (in FLII) interacting protein 1 (201861_s_at), score: -0.45 LSM2LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) (209449_at), score: 0.78 LUZP1leucine zipper protein 1 (221832_s_at), score: -0.49 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: 0.85 MAFFv-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (36711_at), score: -0.47 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: -0.45 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: -0.57 MAP3K4mitogen-activated protein kinase kinase kinase 4 (216199_s_at), score: -0.5 MCM10minichromosome maintenance complex component 10 (220651_s_at), score: 0.81 MCM2minichromosome maintenance complex component 2 (202107_s_at), score: 0.83 MCM3minichromosome maintenance complex component 3 (201555_at), score: 0.8 MCM4minichromosome maintenance complex component 4 (212141_at), score: 0.77 MCM5minichromosome maintenance complex component 5 (216237_s_at), score: 0.86 MCM7minichromosome maintenance complex component 7 (210983_s_at), score: 0.8 MDM1Mdm1 nuclear protein homolog (mouse) (213761_at), score: 0.76 MFAP4microfibrillar-associated protein 4 (212713_at), score: -0.6 MSCmusculin (activated B-cell factor-1) (209928_s_at), score: -0.53 MTSS1metastasis suppressor 1 (203037_s_at), score: -0.71 MYO1Dmyosin ID (212338_at), score: -0.48 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: -0.65 NCAPD3non-SMC condensin II complex, subunit D3 (212789_at), score: 0.81 NCAPGnon-SMC condensin I complex, subunit G (218663_at), score: 0.77 NCAPHnon-SMC condensin I complex, subunit H (212949_at), score: 0.78 NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae) (204162_at), score: 0.8 NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 1 (208093_s_at), score: -0.52 NDRG1N-myc downstream regulated 1 (200632_s_at), score: -0.49 NEDD9neural precursor cell expressed, developmentally down-regulated 9 (202149_at), score: -0.57 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: -0.83 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: -0.66 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: -0.66 NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) (207535_s_at), score: -0.43 NINJ1ninjurin 1 (203045_at), score: -0.46 NPC1Niemann-Pick disease, type C1 (202679_at), score: -0.42 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: -0.7 NR4A1nuclear receptor subfamily 4, group A, member 1 (202340_x_at), score: -0.76 NR4A2nuclear receptor subfamily 4, group A, member 2 (216248_s_at), score: -0.67 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: -0.98 NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae) (219067_s_at), score: 0.76 NUPL1nucleoporin like 1 (204435_at), score: -0.56 NUSAP1nucleolar and spindle associated protein 1 (218039_at), score: 0.78 OLFML2Aolfactomedin-like 2A (213075_at), score: -0.47 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: 0.83 OSMRoncostatin M receptor (205729_at), score: -0.43 PANX1pannexin 1 (204715_at), score: -0.54 PARP2poly (ADP-ribose) polymerase 2 (214086_s_at), score: 0.83 PCTK2PCTAIRE protein kinase 2 (221918_at), score: -0.5 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: -0.66 PDGFDplatelet derived growth factor D (219304_s_at), score: -0.64 PDGFRBplatelet-derived growth factor receptor, beta polypeptide (202273_at), score: -0.47 PIGBphosphatidylinositol glycan anchor biosynthesis, class B (214151_s_at), score: -0.48 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: -0.73 PKMYT1protein kinase, membrane associated tyrosine/threonine 1 (204267_x_at), score: 0.76 PLCXD1phosphatidylinositol-specific phospholipase C, X domain containing 1 (218951_s_at), score: -0.43 PLK3polo-like kinase 3 (Drosophila) (204958_at), score: -0.48 PLSCR4phospholipid scramblase 4 (218901_at), score: -0.54 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: -0.93 POLA1polymerase (DNA directed), alpha 1, catalytic subunit (204835_at), score: 0.84 POLA2polymerase (DNA directed), alpha 2 (70kD subunit) (204441_s_at), score: 0.8 POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa (203422_at), score: 0.87 POLEpolymerase (DNA directed), epsilon (216026_s_at), score: 0.78 POLE2polymerase (DNA directed), epsilon 2 (p59 subunit) (205909_at), score: 0.78 POLR1Cpolymerase (RNA) I polypeptide C, 30kDa (207515_s_at), score: -0.44 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: -0.61 PPLperiplakin (203407_at), score: -0.69 PPP3CCprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (207000_s_at), score: -0.54 PRELPproline/arginine-rich end leucine-rich repeat protein (204223_at), score: -0.45 PRIM1primase, DNA, polypeptide 1 (49kDa) (205053_at), score: 0.82 PRKG1protein kinase, cGMP-dependent, type I (207119_at), score: -0.57 PSMC3IPPSMC3 interacting protein (213951_s_at), score: 0.81 PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (204748_at), score: -0.46 PTHLHparathyroid hormone-like hormone (211756_at), score: -0.69 RAB33ARAB33A, member RAS oncogene family (206039_at), score: -0.44 RAD51AP1RAD51 associated protein 1 (204146_at), score: 0.78 RAD54BRAD54 homolog B (S. cerevisiae) (219494_at), score: 0.79 RAD54LRAD54-like (S. cerevisiae) (204558_at), score: 0.76 RANBP2RAN binding protein 2 (201711_x_at), score: -0.42 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: -0.49 RASA2RAS p21 protein activator 2 (206636_at), score: -0.45 RASGRP1RAS guanyl releasing protein 1 (calcium and DAG-regulated) (205590_at), score: -0.57 RASSF8Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (207754_at), score: -0.5 RCAN2regulator of calcineurin 2 (203498_at), score: -0.51 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: -0.42 RELv-rel reticuloendotheliosis viral oncogene homolog (avian) (206036_s_at), score: -0.56 RELBv-rel reticuloendotheliosis viral oncogene homolog B (205205_at), score: -0.62 RFC3replication factor C (activator 1) 3, 38kDa (204127_at), score: 0.8 RFC4replication factor C (activator 1) 4, 37kDa (204023_at), score: 0.8 RGPD5RANBP2-like and GRIP domain containing 5 (210676_x_at), score: -0.54 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: -0.62 RGS3regulator of G-protein signaling 3 (203823_at), score: -0.44 RHOQras homolog gene family, member Q (212119_at), score: -0.43 RNASEH2Aribonuclease H2, subunit A (203022_at), score: 0.8 RNF103ring finger protein 103 (202636_at), score: -0.44 RPRD2regulation of nuclear pre-mRNA domain containing 2 (212553_at), score: 0.78 RRADRas-related associated with diabetes (204803_s_at), score: -0.65 RUNX1runt-related transcription factor 1 (209360_s_at), score: -0.73 RYBPRING1 and YY1 binding protein (201846_s_at), score: -0.48 SALL1sal-like 1 (Drosophila) (206893_at), score: -0.42 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: -0.6 SCDstearoyl-CoA desaturase (delta-9-desaturase) (200832_s_at), score: -0.45 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: -0.45 SGK1serum/glucocorticoid regulated kinase 1 (201739_at), score: -0.63 SHBSrc homology 2 domain containing adaptor protein B (204657_s_at), score: -0.45 SKILSKI-like oncogene (206675_s_at), score: -0.78 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: -0.86 SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14 (222088_s_at), score: -0.6 SLC2A3P1solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 (221751_at), score: -0.54 SLC46A3solute carrier family 46, member 3 (214719_at), score: -0.44 SMAD7SMAD family member 7 (204790_at), score: -0.43 SMOXspermine oxidase (210357_s_at), score: -0.79 SMURF1SMAD specific E3 ubiquitin protein ligase 1 (212666_at), score: -0.47 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: -0.64 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: -0.73 SPATA2Lspermatogenesis associated 2-like (214965_at), score: -0.66 SPC25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) (209891_at), score: 0.77 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: -0.68 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: -0.68 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: -0.59 SPSB1splA/ryanodine receptor domain and SOCS box containing 1 (219677_at), score: -0.63 SQLEsqualene epoxidase (213562_s_at), score: -0.73 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: -0.44 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: -0.74 SS18L1synovial sarcoma translocation gene on chromosome 18-like 1 (213140_s_at), score: -0.42 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: -0.74 STBD1starch binding domain 1 (203986_at), score: -0.46 STK38Lserine/threonine kinase 38 like (212572_at), score: -0.91 STMN1stathmin 1/oncoprotein 18 (200783_s_at), score: 0.8 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: -0.63 TACC3transforming, acidic coiled-coil containing protein 3 (218308_at), score: 0.77 TACSTD2tumor-associated calcium signal transducer 2 (202286_s_at), score: -0.59 TBX3T-box 3 (219682_s_at), score: -0.52 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: -0.8 THBDthrombomodulin (203887_s_at), score: -0.87 TICAM1toll-like receptor adaptor molecule 1 (213191_at), score: -0.52 TK1thymidine kinase 1, soluble (202338_at), score: 0.79 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: -0.5 TMEM194Atransmembrane protein 194A (212621_at), score: 0.77 TMEM39Atransmembrane protein 39A (218615_s_at), score: -0.51 TMEM41Btransmembrane protein 41B (212623_at), score: -0.64 TMEM87Atransmembrane protein 87A (212202_s_at), score: -0.42 TNFAIP3tumor necrosis factor, alpha-induced protein 3 (202644_s_at), score: -0.58 TNFAIP6tumor necrosis factor, alpha-induced protein 6 (206026_s_at), score: -0.55 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: -0.5 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: -0.46 TNS3tensin 3 (217853_at), score: -0.42 TNXAtenascin XA pseudogene (213451_x_at), score: -0.47 TNXBtenascin XB (216333_x_at), score: -0.51 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: -0.7 TPX2TPX2, microtubule-associated, homolog (Xenopus laevis) (210052_s_at), score: 0.79 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: -0.78 TRIP13thyroid hormone receptor interactor 13 (204033_at), score: 0.78 TRMT5TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae) (221952_x_at), score: 0.78 TRPC6transient receptor potential cation channel, subfamily C, member 6 (217287_s_at), score: -0.46 TTC17tetratricopeptide repeat domain 17 (218972_at), score: -0.62 TTKTTK protein kinase (204822_at), score: 0.79 URB2URB2 ribosome biogenesis 2 homolog (S. cerevisiae) (205284_at), score: -0.46 USTuronyl-2-sulfotransferase (205139_s_at), score: -0.47 UTP3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) (209486_at), score: -0.43 VCLvinculin (200930_s_at), score: -0.64 VEGFAvascular endothelial growth factor A (211527_x_at), score: -0.84 WDHD1WD repeat and HMG-box DNA binding protein 1 (216228_s_at), score: 0.78 WEE1WEE1 homolog (S. pombe) (212533_at), score: 0.85 WISP1WNT1 inducible signaling pathway protein 1 (206796_at), score: -0.6 WWTR1WW domain containing transcription regulator 1 (202132_at), score: -0.51 YOD1YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) (215150_at), score: -0.45 YRDCyrdC domain containing (E. coli) (218647_s_at), score: -0.72 ZCCHC2zinc finger, CCHC domain containing 2 (219062_s_at), score: -0.45 ZFP36L2zinc finger protein 36, C3H type-like 2 (201367_s_at), score: 0.77 ZNF143zinc finger protein 143 (221873_at), score: -0.43 ZNF35zinc finger protein 35 (206096_at), score: -0.58 ZNF672zinc finger protein 672 (218068_s_at), score: -0.62
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-TABM-263-raw-cel-1515485851.cel | 11 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486231.cel | 30 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486331.cel | 35 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| E-TABM-263-raw-cel-1515486351.cel | 36 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| ctrl b 08-03.CEL | 2 | 1 | DS-CC | hgu133a | none | DS-CC 2 |
| 6Twin.CEL | 6 | 2 | DS-twin | hgu133plus2 | none | DS-twin 6 |
| 5CTwin.CEL | 5 | 2 | DS-twin | hgu133plus2 | Down | DS-twin 5 |
| 1Twin.CEL | 1 | 2 | DS-twin | hgu133plus2 | Down | DS-twin 1 |
