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skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

blood vessel development

The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins during acute inflammatory response

Any process activating plasma proteins via proteolysis during an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

cellular alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.

proteolysis

The hydrolysis of a peptide bond or bonds within a protein.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

cell motion

Any process involved in the controlled movement of a cell.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

cell migration

The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

antigen processing and presentation

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

regulation of tissue remodeling

Any process that modulates the frequency, rate, or extent of tissue remodeling.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

tube development

The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.

locomotion

Self-propelled movement of a cell or organism from one location to another.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

regulation of osteoblast differentiation

Any process that modulates the frequency, rate or extent of osteoblast differentiation.

positive regulation of osteoblast differentiation

Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.

bone remodeling

The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.

regulation of bone remodeling

Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

tissue remodeling

The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

localization of cell

Any process by which a cell is transported to, and/or maintained in, a specific location.

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of tissue remodeling

Any process that modulates the frequency, rate, or extent of tissue remodeling.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

tube development

The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

cell motion

Any process involved in the controlled movement of a cell.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

regulation of bone remodeling

Any process that modulates the frequency, rate or extent of bone remodeling, the processes of bone formation and resorption that combine to maintain skeletal integrity.

regulation of osteoblast differentiation

Any process that modulates the frequency, rate or extent of osteoblast differentiation.

positive regulation of osteoblast differentiation

Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.

regulation of osteoblast differentiation

Any process that modulates the frequency, rate or extent of osteoblast differentiation.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

respiratory tube development

The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

positive regulation of osteoblast differentiation

Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.

lung development

The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

activation of plasma proteins during acute inflammatory response

Any process activating plasma proteins via proteolysis during an acute inflammatory response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

G-protein-coupled receptor binding

Interacting selectively with a G-protein-coupled receptor.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

chemokine activity

The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

transcription repressor activity

Any transcription regulator activity that prevents or downregulates transcription.

transcription regulator activity

Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor.

chemokine receptor binding

Interacting selectively with any chemokine receptor.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

This term is the most general term possible

chemokine activity

The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0009605	1.632e-12	13.34	48 ADIPOR2, AQP3, BHLHE40, BMP2, BMP6, C1R, C1RL, C1S, CCL2, CCL7, CCRL1, CD55, CHST2, CLU, CTSD, CXCL1, CXCL2, CXCL3, CXCL6, EGR2, F10, F3, FADS1, FGF7, HBEGF, HMOX1, IL1RAP, IL6, IL8, ITGA1, JMJD3, NFKB1, NINJ1, NPC1, NR4A3, OSMR, PDGFA, PLA2G4C, PLAUR, PPARD, PROS1, SOD2, SRF, THBD, TICAM1, TNFAIP6, TPST1, VEGFA	370	response to external stimulus
GO:0009611	4.529e-12	8.327	37 BMP2, BMP6, C1R, C1RL, C1S, CCL2, CCL7, CD55, CHST2, CLU, CXCL1, CXCL2, CXCL3, CXCL6, F10, F3, FGF7, HBEGF, HMOX1, IL1RAP, IL6, IL8, JMJD3, NFKB1, NINJ1, OSMR, PDGFA, PLA2G4C, PLAUR, PPARD, PROS1, SOD2, SRF, THBD, TICAM1, TNFAIP6, TPST1	231	response to wounding
GO:0002376	2.585e-11	17.12	53 AQP3, BMP6, C1R, C1RL, C1S, CBLB, CCL2, CCL7, CCRL1, CD55, CLU, CXCL1, CXCL2, CXCL3, CXCL6, DNASE2, DPP4, ERAP1, EXOSC9, FCGRT, FOXO3, GCH1, GEM, GPR183, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL11, IL1RAP, IL1RL1, IL6, IL8, ITGA1, JARID2, JMJD6, LIF, NFIL3, NFKB1, NFKB2, RELB, RUNX1, SECTM1, SHB, SOD2, SOX4, TAPBPL, TGFBR1, TICAM1, TNFSF4, TRIM22, VEGFA	475	immune system process
GO:0006955	6.975e-09	10.63	37 BMP6, C1R, C1RL, C1S, CBLB, CCL2, CCL7, CCRL1, CD55, CLU, CXCL1, CXCL2, CXCL3, CXCL6, ERAP1, EXOSC9, FCGRT, GCH1, GEM, GPR183, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL1RAP, IL1RL1, IL6, IL8, LIF, NFIL3, NFKB2, RELB, SECTM1, TICAM1, TNFSF4, TRIM22	295	immune response
GO:0006954	5.426e-08	5.515	25 BMP2, BMP6, C1R, C1RL, C1S, CCL2, CCL7, CD55, CHST2, CLU, CXCL1, CXCL2, CXCL3, CXCL6, HMOX1, IL1RAP, IL6, IL8, JMJD3, NFKB1, OSMR, PLA2G4C, TICAM1, TNFAIP6, TPST1	153	inflammatory response
GO:0050896	6.964e-08	48.66	91 ADIPOR2, ADRA2A, ANGPTL4, AQP3, BBS1, BHLHE40, BMP2, BMP6, C1R, C1RL, C1S, CBLB, CCL2, CCL7, CCRL1, CD55, CHAF1A, CHAF1B, CHST2, CLU, CTSD, CXCL1, CXCL2, CXCL3, CXCL6, DPP4, EGR2, ERAP1, EXOSC9, F10, F3, FADS1, FANCG, FCGRT, FGF7, FOSB, GAA, GCH1, GEM, GPR183, HBEGF, HLA-C, HLA-E, HLA-F, HMGB2, HMOX1, HTR2A, ICAM1, IFITM1, IL1RAP, IL1RL1, IL6, IL8, ITGA1, JMJD3, LGALS3BP, LIF, MAP3K4, NFIL3, NFKB1, NFKB2, NINJ1, NPC1, NR3C1, NR4A3, OSMR, P2RX4, PANX1, PDGFA, PLA2G4C, PLAUR, PPARD, PROS1, RAD51AP1, RELB, RFC3, RFC4, SECTM1, SLC22A18, SOD2, SOD3, SRF, THBD, TICAM1, TNFAIP6, TNFSF4, TP53I11, TPST1, TRIB1, TRIM22, VEGFA	1350	response to stimulus
GO:0065007	1.851e-06	135.8	181 ADIPOR2, ADRA2A, AEBP1, ANGPTL2, ANGPTL4, ANK2, AQP3, AREG, ARID5A, ASAP2, ATP2A2, BBS1, BCL7A, BHLHE40, BMP2, BMP6, BMPR2, C13orf15, C1R, C1RL, C1S, CASP1, CBLB, CCL2, CCL7, CCRL1, CD55, CDK2, CDYL, CHAF1A, CHAF1B, CLU, CORIN, CPZ, CREG1, CXCL1, CXCL6, CXCR7, DHCR7, DKK2, DNASE2, DOCK1, DPP4, EGR2, EGR3, ERAP1, F10, F3, FABP3, FADS1, FANCG, FEM1B, FGF1, FGF7, FOSB, FOXO3, FRY, GAA, GCH1, GEM, GMNN, GPNMB, GPR183, GPR37, GRN, HBEGF, HIPK3, HIVEP1, HLX, HMGB2, HMOX1, HTR2A, ICAM1, IDUA, IFITM1, IL11, IL1RAP, IL1RL1, IL6, IL8, ITGA1, JARID2, JMJD3, JMJD6, JUNB, JUND, LDLR, LGALS3BP, LIF, LITAF, LMCD1, MAD2L1, MAF, MAP3K4, MCM2, MCM5, MCM6, MEIS3P1, MFAP4, MLXIP, MSC, MTSS1, NAB1, NAMPT, NEDD9, NFATC1, NFIL3, NFKB1, NFKB2, NPC1, NPC2, NR3C1, NR4A1, NR4A3, NUSAP1, OSMR, P2RX4, PANX1, PDGFA, PDGFD, PDGFRB, PIK3CD, PLA2G4C, PLAUR, PMEPA1, PPAP2A, PPARD, PRKG1, PROS1, PTHLH, RAB33A, RACGAP1, RAMP1, RAPGEF2, RCAN2, RELB, RFC4, RGS2, RGS3, RRAD, RUNX1, SECTM1, SERPINB2, SERPINF1, SHB, SKIL, SOD2, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SPSB1, SREBF2, SRF, STK38L, TBX3, TGFBR1, THBD, TICAM1, TNFAIP3, TNFAIP6, TNFAIP8, TNFSF4, TNS3, TNXB, TP53BP2, TP53I11, TPP1, TRAF3, TRIB1, TRIM22, VCL, VDR, VEGFA, WISP1, WISP2, WWTR1, ZNF282, ZNF35, ZNF672	3768	biological regulation
GO:0048513	1.872e-06	26.78	58 ANGPTL4, ATP2A2, BBS1, BMP2, BMP6, BMPR2, CCL2, CLU, COL15A1, CRISPLD2, DCN, DHCR7, DNASE2, EGR2, EGR3, ERAP1, FANCG, FGF1, FGF7, FOXO3, GAA, GPNMB, HBEGF, HMOX1, IDUA, IL11, IL6, IL8, JARID2, JMJD6, JUNB, LIF, NFKB1, NFKB2, NINJ1, NR3C1, NR4A3, PDLIM3, PPARD, PPL, PRKG1, PTHLH, RELB, RUNX1, SECTM1, SERPINF1, SHB, SOD2, SOX4, SOX9, SPRY2, SRF, TBX3, TGFBR1, TNFAIP2, TNS3, VDR, VEGFA	743	organ development
GO:0042127	6.216e-06	13.73	37 ADRA2A, BMP2, BMPR2, CCL2, CDK2, CLU, CXCL1, DHCR7, FABP3, FGF1, FGF7, GPNMB, HBEGF, HMOX1, HTR2A, IFITM1, IL11, IL6, IL8, JARID2, LIF, NAMPT, OSMR, PDGFA, PDGFRB, PPAP2A, PTHLH, SOD2, SOX4, SOX9, TBX3, TGFBR1, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA	381	regulation of cell proliferation
GO:0008283	8.840e-06	20.37	47 ADRA2A, AREG, BMP2, BMPR2, CCL2, CDK2, CLU, CREG1, CXCL1, DHCR7, FABP3, FGF1, FGF7, GINS1, GPNMB, HBEGF, HMOX1, HTR2A, IFITM1, IL11, IL6, IL8, INSIG1, JARID2, LIF, LRP1, NAMPT, OSMR, PDGFA, PDGFD, PDGFRB, PPAP2A, PPARD, PTHLH, SERPINF1, SHB, SOD2, SOX4, SOX9, STIL, TBX3, TGFBR1, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA	565	cell proliferation
GO:0006952	1.411e-05	9.48	29 BMP2, BMP6, C1R, C1RL, C1S, CCL2, CCL7, CD55, CHST2, CLU, CXCL1, CXCL2, CXCL3, CXCL6, ERAP1, GCH1, HMOX1, IL1RAP, IL1RL1, IL6, IL8, JMJD3, LGALS3BP, NFKB1, OSMR, PLA2G4C, TICAM1, TNFAIP6, TPST1	263	defense response
GO:0050789	1.666e-05	128.8	171 ADIPOR2, ADRA2A, AEBP1, ANGPTL2, ANGPTL4, ANK2, AQP3, AREG, ARID5A, ASAP2, ATP2A2, BBS1, BCL7A, BHLHE40, BMP2, BMP6, BMPR2, C13orf15, C1R, C1RL, C1S, CASP1, CBLB, CCL2, CCL7, CCRL1, CD55, CDK2, CDYL, CHAF1A, CHAF1B, CLU, CPZ, CREG1, CXCL1, CXCL6, CXCR7, DHCR7, DKK2, DOCK1, DPP4, EGR2, EGR3, ERAP1, FABP3, FADS1, FANCG, FEM1B, FGF1, FGF7, FOSB, FOXO3, FRY, GAA, GEM, GMNN, GPNMB, GPR183, GPR37, GRN, HBEGF, HIPK3, HIVEP1, HLX, HMGB2, HMOX1, HTR2A, ICAM1, IFITM1, IL11, IL1RAP, IL1RL1, IL6, IL8, ITGA1, JARID2, JMJD3, JMJD6, JUNB, JUND, LGALS3BP, LIF, LITAF, LMCD1, MAD2L1, MAF, MAP3K4, MCM2, MCM5, MCM6, MEIS3P1, MFAP4, MLXIP, MSC, MTSS1, NAB1, NAMPT, NEDD9, NFATC1, NFIL3, NFKB1, NFKB2, NPC1, NPC2, NR3C1, NR4A1, NR4A3, NUSAP1, OSMR, P2RX4, PANX1, PDGFA, PDGFD, PDGFRB, PIK3CD, PLA2G4C, PLAUR, PMEPA1, PPAP2A, PPARD, PRKG1, PTHLH, RAB33A, RACGAP1, RAMP1, RAPGEF2, RCAN2, RELB, RFC4, RGS2, RGS3, RRAD, RUNX1, SECTM1, SERPINB2, SERPINF1, SHB, SKIL, SOD2, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SPSB1, SREBF2, SRF, STK38L, TBX3, TGFBR1, TICAM1, TNFAIP3, TNFAIP6, TNFAIP8, TNFSF4, TNS3, TNXB, TP53BP2, TP53I11, TRAF3, TRIB1, TRIM22, VCL, VDR, VEGFA, WISP1, WISP2, WWTR1, ZNF282, ZNF35, ZNF672	3574	regulation of biological process
GO:0006950	1.954e-05	30.93	61 ADRA2A, ANGPTL4, BMP2, BMP6, C1R, C1RL, C1S, CCL2, CCL7, CD55, CHAF1A, CHAF1B, CHST2, CLU, CTSD, CXCL1, CXCL2, CXCL3, CXCL6, DPP4, ERAP1, F10, F3, FADS1, FANCG, FGF7, GCH1, HBEGF, HMGB2, HMOX1, HTR2A, IL1RAP, IL1RL1, IL6, IL8, JMJD3, LGALS3BP, MAP3K4, NFKB1, NINJ1, NPC1, OSMR, P2RX4, PDGFA, PLA2G4C, PLAUR, PPARD, PROS1, RAD51AP1, RFC3, RFC4, SOD2, SOD3, SRF, THBD, TICAM1, TNFAIP6, TP53I11, TPST1, TRIB1, VEGFA	858	response to stress
GO:0040011	3.366e-05	8.219	26 BBS1, CCL2, CCL7, CCRL1, CXCL1, CXCL2, CXCL3, CXCL6, HBEGF, HMOX1, ICAM1, IL6, IL8, ITGA1, PDGFA, PDGFRB, PLAUR, PPAP2A, PPARD, PRKG1, SRF, TGFBR1, TNS3, TRIB1, VCL, VEGFA	228	locomotion
GO:0050794	5.474e-05	124.7	165 ADIPOR2, ADRA2A, AEBP1, ANGPTL2, ANGPTL4, ANK2, AQP3, AREG, ARID5A, ASAP2, ATP2A2, BBS1, BCL7A, BHLHE40, BMP2, BMP6, BMPR2, C13orf15, CASP1, CBLB, CCL2, CCL7, CCRL1, CDK2, CDYL, CHAF1A, CHAF1B, CLU, CPZ, CREG1, CXCL1, CXCL6, CXCR7, DHCR7, DKK2, DOCK1, DPP4, EGR2, EGR3, FABP3, FADS1, FANCG, FEM1B, FGF1, FGF7, FOSB, FOXO3, FRY, GEM, GMNN, GPNMB, GPR183, GPR37, GRN, HBEGF, HIPK3, HIVEP1, HLX, HMGB2, HMOX1, HTR2A, ICAM1, IFITM1, IL11, IL1RAP, IL1RL1, IL6, IL8, ITGA1, JARID2, JMJD3, JMJD6, JUNB, JUND, LGALS3BP, LIF, LITAF, LMCD1, MAD2L1, MAF, MAP3K4, MCM2, MCM5, MCM6, MEIS3P1, MFAP4, MLXIP, MSC, MTSS1, NAB1, NAMPT, NEDD9, NFATC1, NFIL3, NFKB1, NFKB2, NPC1, NPC2, NR3C1, NR4A1, NR4A3, NUSAP1, OSMR, P2RX4, PANX1, PDGFA, PDGFD, PDGFRB, PIK3CD, PLA2G4C, PLAUR, PMEPA1, PPAP2A, PPARD, PRKG1, PTHLH, RAB33A, RACGAP1, RAMP1, RAPGEF2, RCAN2, RELB, RFC4, RGS2, RGS3, RRAD, RUNX1, SECTM1, SERPINB2, SERPINF1, SHB, SKIL, SOD2, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SPSB1, SREBF2, SRF, STK38L, TBX3, TGFBR1, TICAM1, TNFAIP3, TNFAIP6, TNFAIP8, TNFSF4, TNS3, TNXB, TP53BP2, TP53I11, TRAF3, TRIB1, TRIM22, VCL, VDR, VEGFA, WISP1, WISP2, WWTR1, ZNF282, ZNF35, ZNF672	3459	regulation of cellular process
GO:0048518	6.210e-05	31.29	60 ADRA2A, ANGPTL4, AQP3, AREG, BMP2, BMP6, BMPR2, C1R, C1RL, C1S, CASP1, CCL2, CD55, CDK2, CLU, EGR2, ERAP1, FEM1B, FGF1, FGF7, FOXO3, HBEGF, HMOX1, HTR2A, ICAM1, IL11, IL6, IL8, JUNB, JUND, LIF, LITAF, NAMPT, NFKB1, NR4A1, NR4A3, NUSAP1, OSMR, P2RX4, PANX1, PDGFA, PDGFRB, PPARD, PTHLH, RUNX1, SECTM1, SERPINF1, SOD2, SOX4, SOX9, SRF, TBX3, TGFBR1, TICAM1, TNFSF4, TNS3, TP53BP2, TRAF3, VEGFA, WWTR1	868	positive regulation of biological process
GO:0032501	1.087e-04	59.41	94 ADRA2A, ANGPTL2, ANGPTL4, AQP3, ATP2A2, BBS1, BHLHE40, BMP2, BMP6, BMPR2, CCL2, CHST2, CLU, COL15A1, CORIN, CREG1, CRISPLD2, CXCL1, DCN, DHCR7, DKK2, DNASE2, EGR2, EGR3, ERAP1, F10, F3, FANCG, FGF1, FGF7, FOSB, FOXO3, GAA, GCH1, GINS1, GPNMB, HBEGF, HK2, HLX, HMOX1, HTR2A, IDUA, IL11, IL6, IL8, JARID2, JMJD6, JUNB, JUND, LDLR, LIF, LRP1, NFKB1, NFKB2, NINJ1, NR3C1, NR4A3, P2RX4, PANX1, PDGFA, PDLIM3, PLAUR, PPARD, PPL, PRELP, PRKG1, PROS1, PTHLH, RELB, RUNX1, SECTM1, SERPINF1, SHB, SKIL, SLC19A2, SLC22A18, SOD2, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SRF, STIL, TBX3, TGFBR1, THBD, TNFAIP2, TNS3, TNXB, TPP1, VDR, VEGFA, WWTR1	1648	multicellular organismal process
GO:0006935	1.553e-04	2.487	13 CCL2, CCL7, CCRL1, CXCL1, CXCL2, CXCL3, CXCL6, IL6, IL8, ITGA1, PDGFA, PLAUR, VEGFA	69	chemotaxis
GO:0042330	1.553e-04	2.487	13 CCL2, CCL7, CCRL1, CXCL1, CXCL2, CXCL3, CXCL6, IL6, IL8, ITGA1, PDGFA, PLAUR, VEGFA	69	taxis
GO:0008284	1.875e-04	6.813	22 ADRA2A, CCL2, CDK2, CLU, FGF1, FGF7, HBEGF, HTR2A, IL11, IL6, LIF, NAMPT, OSMR, PDGFA, PDGFRB, PTHLH, SOX4, TBX3, TGFBR1, TNFSF4, TNS3, VEGFA	189	positive regulation of cell proliferation
GO:0007275	2.551e-04	46.28	77 ANGPTL2, ANGPTL4, ATP2A2, BBS1, BMP2, BMP6, BMPR2, CCL2, CHST2, CLU, COL15A1, CREG1, CRISPLD2, CXCL1, DCN, DHCR7, DKK2, DNASE2, EGR2, EGR3, ERAP1, FANCG, FGF1, FGF7, FOSB, FOXO3, GAA, GINS1, GPNMB, HBEGF, HLX, HMOX1, IDUA, IL11, IL6, IL8, JARID2, JMJD6, JUNB, JUND, LIF, LRP1, NFKB1, NFKB2, NINJ1, NR3C1, NR4A3, PDGFA, PDLIM3, PPARD, PPL, PRELP, PRKG1, PTHLH, RELB, RUNX1, SECTM1, SERPINF1, SHB, SKIL, SOD2, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SRF, STIL, TBX3, TGFBR1, THBD, TNFAIP2, TNS3, TPP1, VDR, VEGFA, WWTR1	1284	multicellular organismal development
GO:0045597	2.957e-04	3.064	14 BMP2, BMP6, BMPR2, CLU, FOXO3, IL6, JUNB, JUND, LIF, NFKB1, PPARD, RUNX1, SERPINF1, SRF	85	positive regulation of cell differentiation
GO:0007610	3.207e-04	5.984	20 BBS1, CCL2, CCL7, CCRL1, CXCL1, CXCL2, CXCL3, CXCL6, EGR2, FOSB, GAA, HTR2A, IL6, IL8, ITGA1, NR4A3, PDGFA, PLAUR, SOD2, VEGFA	166	behavior
GO:0007154	4.262e-04	70.18	104 ADIPOR2, ADRA2A, ANGPTL2, ANGPTL4, ANK2, AREG, ASAP2, ATP2A2, BHLHE40, BMP2, BMP6, BMPR2, CASP1, CBLB, CCL2, CCL7, CCRL1, CPZ, CTSD, CXCL1, CXCL6, CXCR7, DKK2, DOCK1, EGR2, EGR3, FADS1, FGF1, FGF7, GEM, GPR183, GPR37, GRN, HBEGF, HMGB2, HMOX1, HTR2A, IFITM1, IL11, IL1RAP, IL1RL1, IL6, IL8, ITGA1, JMJD6, LGALS3BP, LIF, LITAF, MAP3K4, MFAP4, MTSS1, NAMPT, NEDD9, NFATC1, NFKB1, NFKB2, NPC1, NR3C1, NR4A1, OSMR, P2RX4, PDGFA, PDGFRB, PIK3CD, PLA2G4C, PLAUR, PMEPA1, PPAP2A, PPARD, PRKG1, PTHLH, RAB33A, RACGAP1, RAMP1, RAPGEF2, RCAN2, RFC4, RGS2, RGS3, RRAD, SECTM1, SHB, SKIL, SOD2, SOX4, SPRED2, SPRY2, SPRY4, SPSB1, STK38L, TBX3, TGFBR1, TICAM1, TNFAIP3, TNFAIP6, TNFSF4, TNXB, TP53BP2, TRAF3, TRIB1, VDR, VEGFA, WISP1, WISP2	1947	cell communication
GO:0007626	4.574e-04	3.641	15 CCL2, CCL7, CCRL1, CXCL1, CXCL2, CXCL3, CXCL6, GAA, IL6, IL8, ITGA1, PDGFA, PLAUR, SOD2, VEGFA	101	locomotory behavior
GO:0032502	4.796e-04	68.6	102 ADIPOR2, ANGPTL2, ANGPTL4, AQP3, ATP2A2, BBS1, BMP2, BMP6, BMPR2, CASP1, CCL2, CHST2, CKAP2, CLU, COL15A1, CORIN, CREG1, CRISPLD2, CXCL1, DCN, DHCR7, DKK2, DNASE2, DOCK1, DRAM, EGR2, EGR3, ERAP1, FADS1, FANCG, FEM1B, FGF1, FGF7, FOSB, FOXO3, GAA, GINS1, GNPTAB, GPNMB, HBEGF, HIPK3, HLX, HMOX1, HTR2A, IDUA, IL11, IL6, IL8, JARID2, JMJD6, JUNB, JUND, LIF, LITAF, LRP1, MTSS1, NFKB1, NFKB2, NINJ1, NR3C1, NR4A1, NR4A3, P2RX4, PDGFA, PDLIM3, PPARD, PPL, PRELP, PRKG1, PTHLH, RACGAP1, RELB, RUNX1, SECTM1, SERPINB2, SERPINF1, SHB, SKIL, SOD2, SOX4, SOX9, SPRED2, SPRY2, SPRY4, SRF, STIL, TBX3, TGFBR1, THBD, TICAM1, TNFAIP2, TNFAIP3, TNFAIP8, TNS3, TP53BP2, TPP1, TRAF3, VDR, VEGFA, WISP1, WISP2, WWTR1	1903	developmental process
GO:0001649	6.677e-04	1.009	8 BMP2, BMP6, BMPR2, GPNMB, IL6, JUND, PTHLH, WWTR1	28	osteoblast differentiation
GO:0007165	7.492e-04	64.88	97 ADIPOR2, ADRA2A, ANGPTL2, ANGPTL4, ANK2, AREG, ASAP2, ATP2A2, BMP2, BMP6, BMPR2, CASP1, CBLB, CCL2, CCL7, CCRL1, CPZ, CXCL1, CXCL6, CXCR7, DKK2, DOCK1, FGF1, FGF7, GEM, GPR183, GPR37, GRN, HBEGF, HMGB2, HMOX1, HTR2A, IFITM1, IL11, IL1RAP, IL1RL1, IL6, IL8, ITGA1, JMJD6, LGALS3BP, LIF, LITAF, MAP3K4, MFAP4, MTSS1, NAMPT, NEDD9, NFATC1, NFKB1, NFKB2, NR3C1, NR4A1, OSMR, P2RX4, PDGFA, PDGFRB, PIK3CD, PLA2G4C, PLAUR, PMEPA1, PPAP2A, PPARD, PRKG1, PTHLH, RAB33A, RACGAP1, RAMP1, RAPGEF2, RCAN2, RFC4, RGS2, RGS3, RRAD, SECTM1, SHB, SKIL, SOD2, SOX4, SPRED2, SPRY2, SPRY4, SPSB1, STK38L, TGFBR1, TICAM1, TNFAIP3, TNFAIP6, TNFSF4, TNXB, TP53BP2, TRAF3, TRIB1, VDR, VEGFA, WISP1, WISP2	1800	signal transduction
GO:0048731	7.622e-04	36.37	63 ANGPTL4, ATP2A2, BBS1, BMP2, BMP6, BMPR2, CCL2, CLU, COL15A1, CRISPLD2, CXCL1, DCN, DHCR7, DNASE2, EGR2, EGR3, ERAP1, FANCG, FGF1, FGF7, FOXO3, GAA, GPNMB, HBEGF, HMOX1, IDUA, IL11, IL6, IL8, JARID2, JMJD6, JUNB, JUND, LIF, NFKB1, NFKB2, NINJ1, NR3C1, NR4A3, PDLIM3, PPARD, PPL, PRELP, PRKG1, PTHLH, RELB, RUNX1, SECTM1, SERPINF1, SHB, SOD2, SOX4, SOX9, SPRY2, SRF, TBX3, TGFBR1, TNFAIP2, TNS3, TPP1, VDR, VEGFA, WWTR1	1009	system development
GO:0009887	9.746e-04	11.25	28 ANGPTL4, BBS1, BMP2, CCL2, COL15A1, DCN, ERAP1, FGF1, GAA, HMOX1, IDUA, IL6, IL8, JARID2, JUNB, NR4A3, PTHLH, SERPINF1, SHB, SOD2, SOX9, SPRY2, SRF, TBX3, TGFBR1, TNFAIP2, VDR, VEGFA	312	organ morphogenesis
GO:0045595	1.208e-03	6.597	20 AQP3, BMP2, BMP6, BMPR2, CLU, FADS1, FOXO3, IL6, JUNB, JUND, LIF, NFKB1, PPARD, PTHLH, RUNX1, SERPINF1, SOD2, SRF, TBX3, WWTR1	183	regulation of cell differentiation
GO:0030154	1.833e-03	24.3	46 ANGPTL4, AQP3, BBS1, BMP2, BMP6, BMPR2, CLU, COL15A1, DHCR7, DNASE2, EGR2, ERAP1, FADS1, FANCG, FGF1, FOXO3, GNPTAB, GPNMB, HLX, IL11, IL6, JMJD6, JUNB, JUND, LIF, NFKB1, NFKB2, PPARD, PPL, PRKG1, PTHLH, RACGAP1, RELB, RUNX1, SERPINF1, SHB, SOD2, SOX4, SOX9, SPRY2, SRF, TBX3, TGFBR1, TNFAIP2, VEGFA, WWTR1	674	cell differentiation
GO:0016125	2.227e-03	2.343	11 CYP51A1, DHCR7, HMGCS1, IDI1, INSIG1, LDLR, PPARD, SC4MOL, SCARB1, SQLE, SREBF2	65	sterol metabolic process
GO:0048870	2.362e-03	6.38	19 BBS1, CCL2, HBEGF, HMOX1, ICAM1, IL6, IL8, ITGA1, PDGFA, PDGFRB, PPAP2A, PPARD, PRKG1, SRF, TGFBR1, TNS3, TRIB1, VCL, VEGFA	177	cell motility
GO:0042060	3.074e-03	2.884	12 F10, F3, HBEGF, HMOX1, IL6, NINJ1, PDGFA, PLAUR, PPARD, PROS1, SRF, THBD	80	wound healing
GO:0001568	3.572e-03	4.938	16 ANGPTL4, COL15A1, DHCR7, ERAP1, FGF1, HMOX1, IL6, IL8, JMJD6, JUNB, SERPINF1, SHB, SRF, TGFBR1, TNFAIP2, VEGFA	137	blood vessel development
GO:0048522	4.160e-03	29.09	51 ADRA2A, AREG, BMP2, BMP6, BMPR2, CASP1, CCL2, CDK2, CLU, EGR2, FEM1B, FGF1, FGF7, FOXO3, HBEGF, HMOX1, HTR2A, ICAM1, IL11, IL6, JUNB, JUND, LIF, LITAF, NAMPT, NFKB1, NR4A1, NR4A3, NUSAP1, OSMR, P2RX4, PDGFA, PDGFRB, PPARD, PTHLH, RUNX1, SECTM1, SERPINF1, SOD2, SOX4, SOX9, SRF, TBX3, TGFBR1, TICAM1, TNFSF4, TNS3, TP53BP2, TRAF3, VEGFA, WWTR1	807	positive regulation of cellular process
GO:0001944	4.167e-03	5.011	16 ANGPTL4, COL15A1, DHCR7, ERAP1, FGF1, HMOX1, IL6, IL8, JMJD6, JUNB, SERPINF1, SHB, SRF, TGFBR1, TNFAIP2, VEGFA	139	vasculature development
GO:0016477	4.504e-03	6.164	18 CCL2, HBEGF, HMOX1, ICAM1, IL6, IL8, ITGA1, PDGFA, PDGFRB, PPAP2A, PPARD, PRKG1, SRF, TGFBR1, TNS3, TRIB1, VCL, VEGFA	171	cell migration
GO:0048519	4.685e-03	33.2	56 ADIPOR2, ANGPTL4, ARID5A, ATP2A2, BCL7A, BHLHE40, BMP2, BMPR2, CCL2, CLU, CXCL1, DKK2, FABP3, FOSB, GMNN, GPNMB, HIPK3, HMGB2, HMOX1, HTR2A, IFITM1, IL11, IL1RL1, IL6, IL8, JARID2, JMJD3, LIF, LMCD1, MAF, MTSS1, NAB1, NFKB1, NPC1, P2RX4, PDGFA, PPAP2A, PTHLH, RGS2, RGS3, SERPINB2, SERPINF1, SOD2, SOX4, SOX9, TBX3, TGFBR1, TNFAIP3, TNFAIP8, TP53BP2, TP53I11, TRIB1, VCL, VDR, VEGFA, WWTR1	921	negative regulation of biological process
GO:0030324	5.319e-03	1.37	8 BMPR2, CRISPLD2, DHCR7, FGF1, JMJD6, PTHLH, SPRY2, TNS3	38	lung development
GO:0048869	6.536e-03	29.7	51 ADIPOR2, ANGPTL4, AQP3, BBS1, BMP2, BMP6, BMPR2, CLU, COL15A1, DHCR7, DNASE2, EGR2, ERAP1, FADS1, FANCG, FGF1, FOXO3, GNPTAB, GPNMB, HLX, IDUA, IL11, IL6, JMJD6, JUNB, JUND, LIF, MTSS1, NFKB1, NFKB2, PPARD, PPL, PRKG1, PTHLH, RACGAP1, RELB, RUNX1, SERPINF1, SHB, SOD2, SOX4, SOX9, SPRY2, SRF, TBX3, TGFBR1, TNFAIP2, VEGFA, WISP1, WISP2, WWTR1	824	cellular developmental process
GO:0065008	6.643e-03	23.54	43 ADIPOR2, ATP2A2, BBS1, BMP6, BMPR2, CCL2, CCL7, CD55, CORIN, DNASE2, EGR2, ERAP1, F10, F3, FOXO3, GAA, GCH1, HMOX1, HTR2A, IDUA, IL11, IL6, JMJD6, LDLR, LIF, NPC1, NPC2, NR3C1, P2RX4, PDGFA, PLAUR, PROS1, PTHLH, SOD2, SRF, TBX3, TGFBR1, THBD, TPP1, VDR, VEGFA, WISP1, WISP2	653	regulation of biological quality
GO:0048856	6.790e-03	44.45	69 ADIPOR2, ANGPTL4, ATP2A2, BBS1, BMP2, BMP6, BMPR2, CCL2, CLU, COL15A1, CORIN, CRISPLD2, CXCL1, DCN, DHCR7, DNASE2, EGR2, EGR3, ERAP1, FANCG, FGF1, FGF7, FOXO3, GAA, GINS1, GPNMB, HBEGF, HMOX1, IDUA, IL11, IL6, IL8, JARID2, JMJD6, JUNB, JUND, LIF, MTSS1, NFKB1, NFKB2, NINJ1, NR3C1, NR4A3, PDLIM3, PPARD, PPL, PRELP, PRKG1, PTHLH, RELB, RUNX1, SECTM1, SERPINF1, SHB, SOD2, SOX4, SOX9, SPRY2, SRF, TBX3, TGFBR1, TNFAIP2, TNS3, TPP1, VDR, VEGFA, WISP1, WISP2, WWTR1	1233	anatomical structure development
GO:0048646	6.803e-03	5.263	16 ANGPTL4, BMPR2, COL15A1, EGR2, ERAP1, FGF1, HMOX1, IL6, IL8, JUNB, NR4A3, SERPINF1, SHB, SRF, TNFAIP2, VEGFA	146	anatomical structure formation
GO:0019882	7.268e-03	1.442	8 ERAP1, FCGRT, HLA-C, HLA-E, HLA-F, ICAM1, RELB, TAPBPL	40	antigen processing and presentation
GO:0030323	7.268e-03	1.442	8 BMPR2, CRISPLD2, DHCR7, FGF1, JMJD6, PTHLH, SPRY2, TNS3	40	respiratory tube development
GO:0006959	7.323e-03	1.081	7 C1R, C1RL, C1S, CCL2, CD55, CLU, IL6	30	humoral immune response
GO:0050900	7.323e-03	1.081	7 CCL2, HMOX1, ICAM1, IL6, IL8, ITGA1, VEGFA	30	leukocyte migration
GO:0006958	8.641e-03	0.5047	5 C1R, C1RL, C1S, CD55, CLU	14	complement activation, classical pathway
GO:0045669	8.641e-03	0.5047	5 BMP2, BMP6, BMPR2, IL6, JUND	14	positive regulation of osteoblast differentiation
GO:0006928	9.168e-03	9.697	23 ADRA2A, BBS1, CCL2, EGR2, HBEGF, HMOX1, ICAM1, IL6, IL8, ITGA1, MTSS1, PDGFA, PDGFRB, PLAUR, PPAP2A, PPARD, PRKG1, SRF, TGFBR1, TNS3, TRIB1, VCL, VEGFA	269	cell motion
GO:0051674	9.168e-03	9.697	23 ADRA2A, BBS1, CCL2, EGR2, HBEGF, HMOX1, ICAM1, IL6, IL8, ITGA1, MTSS1, PDGFA, PDGFRB, PLAUR, PPAP2A, PPARD, PRKG1, SRF, TGFBR1, TNS3, TRIB1, VCL, VEGFA	269	localization of cell
GO:0009888	1.126e-02	5.551	16 ATP2A2, BMP2, BMP6, BMPR2, FGF7, GAA, GPNMB, JUNB, NINJ1, NR4A3, PPARD, PPL, PTHLH, SECTM1, SOX9, TBX3	154	tissue development
GO:0048583	1.128e-02	4.434	14 C1R, C1RL, C1S, CD55, CLU, ERAP1, HMOX1, ICAM1, IL6, IL8, NPC1, OSMR, PDGFA, VEGFA	123	regulation of response to stimulus
GO:0048523	1.138e-02	31.32	52 ADIPOR2, ANGPTL4, ARID5A, BCL7A, BHLHE40, BMP2, CCL2, CLU, CXCL1, DKK2, FABP3, FOSB, GMNN, GPNMB, HIPK3, HMGB2, HMOX1, HTR2A, IFITM1, IL11, IL1RL1, IL6, IL8, JARID2, JMJD3, LIF, LMCD1, MAF, MTSS1, NAB1, NFKB1, NPC1, PDGFA, PPAP2A, PTHLH, RGS2, RGS3, SERPINB2, SOD2, SOX4, SOX9, TBX3, TGFBR1, TNFAIP3, TNFAIP8, TP53BP2, TP53I11, TRIB1, VCL, VDR, VEGFA, WWTR1	869	negative regulation of cellular process
GO:0002455	1.158e-02	0.5407	5 C1R, C1RL, C1S, CD55, CLU	15	humoral immune response mediated by circulating immunoglobulin
GO:0048514	1.206e-02	4.47	14 ANGPTL4, COL15A1, ERAP1, FGF1, HMOX1, IL6, IL8, JUNB, SERPINF1, SHB, SRF, TGFBR1, TNFAIP2, VEGFA	124	blood vessel morphogenesis
GO:0008217	1.217e-02	1.19	7 BMPR2, CORIN, ERAP1, GCH1, HMOX1, P2RX4, SOD2	33	regulation of blood pressure
GO:0042221	1.353e-02	15.54	31 ADIPOR2, AQP3, BBS1, CCL2, CCL7, CCRL1, CLU, CXCL1, CXCL2, CXCL3, CXCL6, EGR2, GCH1, HMOX1, HTR2A, IL6, IL8, ITGA1, NPC1, NR3C1, OSMR, P2RX4, PANX1, PDGFA, PLAUR, SLC22A18, SOD2, SRF, THBD, TRIB1, VEGFA	431	response to chemical stimulus
GO:0040012	1.444e-02	2.992	11 BBS1, HBEGF, HMOX1, ICAM1, IL6, IL8, PDGFA, PDGFRB, TRIB1, VCL, VEGFA	83	regulation of locomotion
GO:0008203	1.458e-02	2.055	9 CYP51A1, DHCR7, HMGCS1, IDI1, INSIG1, LDLR, PPARD, SCARB1, SREBF2	57	cholesterol metabolic process
GO:0002685	1.481e-02	0.3244	4 HMOX1, ICAM1, IL6, VEGFA	9	regulation of leukocyte migration
GO:0033135	1.482e-02	0.1442	3 IL11, IL6, LIF	4	regulation of peptidyl-serine phosphorylation
GO:0033138	1.482e-02	0.1442	3 IL11, IL6, LIF	4	positive regulation of peptidyl-serine phosphorylation
GO:0006366	1.555e-02	17.88	34 BMP2, BMP6, BMPR2, CREG1, EGR2, FOSB, FOXO3, HMGB2, HMOX1, IL11, IL6, JARID2, JMJD3, JUNB, JUND, LIF, LITAF, LMCD1, MAF, MSC, NFATC1, NFIL3, NFKB1, NR3C1, NR4A1, NR4A3, RUNX1, SKIL, SOD2, SOX9, SREBF2, SRF, TBX3, WWTR1	496	transcription from RNA polymerase II promoter
GO:0008202	1.586e-02	4.073	13 BMP6, CYP51A1, DHCR7, HMGCS1, IDI1, INSIG1, LDLR, NR3C1, PPARD, SC4MOL, SCARB1, SQLE, SREBF2	113	steroid metabolic process
GO:0051239	1.625e-02	11.54	25 ANGPTL4, ATP2A2, BHLHE40, BMP2, BMP6, BMPR2, EGR2, ERAP1, FOXO3, GAA, HBEGF, HMOX1, HTR2A, IL6, JUND, LIF, NFKB1, P2RX4, PANX1, PDGFA, PTHLH, RUNX1, SERPINF1, SRF, TBX3	320	regulation of multicellular organismal process
GO:0045444	1.638e-02	0.9012	6 BBS1, ERAP1, IL11, PPARD, SOD2, WWTR1	25	fat cell differentiation
GO:0006629	1.736e-02	15.82	31 ADIPOR2, APOD, BBS1, BMP6, CLU, CORIN, CYP51A1, DHCR7, FABP3, FADS1, HMGCS1, IDI1, INSIG1, LDLR, LRP1, NFKB1, NPC2, NR3C1, PDGFA, PIGB, PIK3CD, PLA2G4C, PLAUR, PPAP2A, PPARD, PTGDS, SC4MOL, SCARB1, SQLE, SREBF2, TPP1	439	lipid metabolic process
GO:0010646	1.795e-02	15.14	30 ASAP2, BHLHE40, BMP2, CASP1, DKK2, EGR2, HMOX1, HTR2A, IL11, IL1RL1, IL6, LIF, LITAF, NPC1, P2RX4, PPARD, RAMP1, RAPGEF2, RGS2, RGS3, SECTM1, SOX4, SPRED2, SPRY2, SPRY4, TGFBR1, TICAM1, TNFAIP3, TRIB1, VEGFA	420	regulation of cell communication
GO:0007267	1.811e-02	9.625	22 AREG, BHLHE40, BMP2, CCL7, CXCL6, EGR2, EGR3, FADS1, FGF1, HTR2A, IL11, IL6, IL8, LIF, NAMPT, PDGFA, PTHLH, SPRY2, TBX3, TNFAIP6, WISP1, WISP2	267	cell-cell signaling
GO:0002474	1.922e-02	0.6128	5 ERAP1, HLA-C, HLA-E, HLA-F, TAPBPL	17	antigen processing and presentation of peptide antigen via MHC class I
GO:0002541	1.922e-02	0.6128	5 C1R, C1RL, C1S, CD55, CLU	17	activation of plasma proteins during acute inflammatory response
GO:0006956	1.922e-02	0.6128	5 C1R, C1RL, C1S, CD55, CLU	17	complement activation
GO:0006357	2.053e-02	13.16	27 BMP2, BMP6, CREG1, EGR2, FOSB, FOXO3, HMGB2, HMOX1, IL11, IL6, JARID2, JMJD3, JUNB, JUND, LIF, LITAF, LMCD1, NFKB1, NR4A1, NR4A3, RUNX1, SOD2, SOX9, SREBF2, SRF, TBX3, WWTR1	365	regulation of transcription from RNA polymerase II promoter
GO:0002682	2.122e-02	5.371	15 AQP3, C1R, C1RL, C1S, CD55, CLU, ERAP1, FOXO3, HMOX1, ICAM1, IL6, LIF, NFKB1, RUNX1, VEGFA	149	regulation of immune system process
GO:0002526	2.163e-02	1.334	7 C1R, C1RL, C1S, CD55, CLU, IL6, OSMR	37	acute inflammatory response
GO:0001525	2.371e-02	3.749	12 ANGPTL4, COL15A1, ERAP1, FGF1, HMOX1, IL6, IL8, SERPINF1, SHB, SRF, TNFAIP2, VEGFA	104	angiogenesis
GO:0018105	2.391e-02	0.6488	5 HIPK3, IL11, IL6, LIF, TGFBR1	18	peptidyl-serine phosphorylation
GO:0045667	2.391e-02	0.6488	5 BMP2, BMP6, BMPR2, IL6, JUND	18	regulation of osteoblast differentiation
GO:0051270	2.488e-02	3.244	11 BBS1, HBEGF, HMOX1, ICAM1, IL6, PDGFA, PDGFRB, TGFBR1, TRIB1, VCL, VEGFA	90	regulation of cell motion
GO:0003013	2.674e-02	3.28	11 ATP2A2, BMPR2, CORIN, ERAP1, GAA, GCH1, HBEGF, HMOX1, HTR2A, P2RX4, SOD2	91	circulatory system process
GO:0008015	2.674e-02	3.28	11 ATP2A2, BMPR2, CORIN, ERAP1, GAA, GCH1, HBEGF, HMOX1, HTR2A, P2RX4, SOD2	91	blood circulation
GO:0046849	2.774e-02	1.406	7 BMP2, BMP6, BMPR2, EGR2, IL6, JUND, TPP1	39	bone remodeling
GO:0048286	2.867e-02	0.1802	3 BMPR2, PTHLH, TNS3	5	alveolus development
GO:0045087	3.094e-02	2.343	9 C1R, C1RL, C1S, CD55, CLU, ERAP1, GCH1, IL1RAP, IL1RL1	65	innate immune response
GO:0044057	3.629e-02	2.92	10 ATP2A2, BHLHE40, BMPR2, EGR2, GAA, HBEGF, HMOX1, HTR2A, P2RX4, SRF	81	regulation of system process
GO:0001503	3.630e-02	2.415	9 BMP2, BMP6, BMPR2, EGR2, GPNMB, IL6, JUND, PTHLH, WWTR1	67	ossification
GO:0060348	3.630e-02	2.415	9 BMP2, BMP6, BMPR2, EGR2, GPNMB, IL6, JUND, PTHLH, WWTR1	67	bone development
GO:0006066	3.726e-02	7.029	17 CYP51A1, DHCR7, GAA, GALNAC4S-6ST, GCH1, GFPT2, HK2, HMGCS1, IDI1, INSIG1, LDLR, NR3C1, PPARD, SC4MOL, SCARB1, SQLE, SREBF2	195	cellular alcohol metabolic process
GO:0001501	3.824e-02	5.804	15 BMP2, BMP6, BMPR2, EGR2, GPNMB, IDUA, IL6, JUND, PRELP, PTHLH, SOX9, TBX3, TGFBR1, VDR, WWTR1	161	skeletal system development
GO:0045944	3.973e-02	5.227	14 BMP2, BMP6, EGR2, FOXO3, IL11, IL6, LIF, NFKB1, NR4A1, NR4A3, RUNX1, SOX9, SRF, WWTR1	145	positive regulation of transcription from RNA polymerase II promoter
GO:0018209	4.132e-02	0.757	5 HIPK3, IL11, IL6, LIF, TGFBR1	21	peptidyl-serine modification
GO:0048002	4.132e-02	0.757	5 ERAP1, HLA-C, HLA-E, HLA-F, TAPBPL	21	antigen processing and presentation of peptide antigen
GO:0048584	4.216e-02	2.487	9 C1R, C1RL, C1S, CD55, CLU, IL6, IL8, OSMR, VEGFA	69	positive regulation of response to stimulus
GO:0006260	4.316e-02	6.525	16 AREG, CDK2, CHAF1A, CHAF1B, GINS1, GINS2, GMNN, HMGB2, MCM2, MCM5, MCM6, ORC6L, PDGFA, RFC3, RFC4, TK1	181	DNA replication
GO:0006694	4.380e-02	2.019	8 BMP6, CYP51A1, DHCR7, HMGCS1, IDI1, NR3C1, SC4MOL, SQLE	56	steroid biosynthetic process
GO:0030278	4.494e-02	1.154	6 BMP2, BMP6, BMPR2, EGR2, IL6, JUND	32	regulation of ossification
GO:0048008	4.502e-02	0.2163	3 PDGFA, PDGFRB, VEGFA	6	platelet-derived growth factor receptor signaling pathway
GO:0051272	4.631e-02	1.586	7 HBEGF, ICAM1, IL6, PDGFA, PDGFRB, TGFBR1, VEGFA	44	positive regulation of cell motion
GO:0002443	4.717e-02	2.055	8 C1R, C1RL, C1S, CD55, CLU, HMOX1, ICAM1, IL6	57	leukocyte mediated immunity
GO:0002460	4.717e-02	2.055	8 C1R, C1RL, C1S, CD55, CLU, ICAM1, NFKB2, RELB	57	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0051094	4.999e-02	10.71	22 ANGPTL4, BMP2, BMP6, BMPR2, CLU, ERAP1, FEM1B, FOXO3, HMOX1, IL6, JUNB, JUND, LIF, NFKB1, NR4A1, PPARD, RUNX1, SERPINF1, SOX4, SRF, TP53BP2, TRAF3	297	positive regulation of developmental process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005576	1.340e-12	24.55	67 AEBP1, ANGPTL2, ANGPTL4, APOD, AREG, BMP2, BMP6, C1R, C1RL, C1S, CCL2, CCL7, CLU, COL14A1, COL15A1, CPZ, CREG1, CRISPLD2, CTSD, CXCL1, CXCL2, CXCL3, CXCL6, DCN, DKK2, DPP4, ERAP1, F10, FGF1, FGF7, GRN, HBEGF, HLA-C, HMOX1, ICAM1, IL11, IL1RAP, IL1RL1, IL6, IL8, LGALS3BP, LIF, MFAP4, NID1, NPC2, OLFML2A, PDGFA, PDGFD, PDGFRL, PLAUR, PRELP, PROS1, PTGDS, PTHLH, SECTM1, SERPINB2, SERPINF1, SOD3, ST3GAL1, SVEP1, THBD, TNFAIP2, TNFSF4, TNXB, VEGFA, WISP1, WISP2	700	extracellular region
GO:0005615	5.156e-10	8.626	34 ANGPTL2, ANGPTL4, APOD, AREG, BMP2, BMP6, C1RL, CCL2, CCL7, CLU, CXCL1, CXCL2, CXCL3, CXCL6, DKK2, FGF1, GRN, HBEGF, HMOX1, ICAM1, IL11, IL6, IL8, LGALS3BP, LIF, PDGFA, PTHLH, SECTM1, SERPINF1, SOD3, THBD, TNFAIP2, TNFSF4, VEGFA	246	extracellular space
GO:0044421	1.081e-09	13.57	43 ANGPTL2, ANGPTL4, APOD, AREG, BMP2, BMP6, C1RL, CCL2, CCL7, CLU, COL14A1, COL15A1, CPZ, CXCL1, CXCL2, CXCL3, CXCL6, DCN, DKK2, FGF1, GRN, HBEGF, HMOX1, ICAM1, IL11, IL6, IL8, LGALS3BP, LIF, MFAP4, NID1, OLFML2A, PDGFA, PRELP, PTHLH, SECTM1, SERPINF1, SOD3, THBD, TNFAIP2, TNFSF4, TNXB, VEGFA	387	extracellular region part
GO:0042612	3.530e-02	0.526	4 FCGRT, HLA-C, HLA-E, HLA-F	15	MHC class I protein complex

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005125	4.040e-07	2.436	17 AREG, BMP2, BMP6, CCL2, CCL7, CXCL1, CXCL2, CXCL6, GRN, IL11, IL6, IL8, LIF, NAMPT, SECTM1, TNFSF4, VEGFA	73	cytokine activity
GO:0004871	1.025e-04	26.63	54 ADIPOR2, ADRA2A, BMPR2, CBLB, CCL2, CCRL1, CORIN, CXCR7, FCGRT, GPR183, GPR37, HBEGF, HLA-C, HLA-E, HLA-F, HMOX1, HTR2A, ICAM1, IFITM1, IL1RAP, IL1RL1, ITGA1, JMJD6, LDLR, LGALS3BP, LITAF, LRP1, MAP3K4, NPC1, NR3C1, NR4A1, NR4A3, OSMR, P2RX4, PDGFRB, PDGFRL, PLAUR, PLK3, PPARD, PTPRE, RAMP1, RAPGEF2, RGS2, RGS3, SCARB1, SECTM1, SHB, SKIL, TGFBR1, THBD, TICAM1, TP53BP2, TRAF3, VDR	798	signal transducer activity
GO:0060089	1.025e-04	26.63	54 ADIPOR2, ADRA2A, BMPR2, CBLB, CCL2, CCRL1, CORIN, CXCR7, FCGRT, GPR183, GPR37, HBEGF, HLA-C, HLA-E, HLA-F, HMOX1, HTR2A, ICAM1, IFITM1, IL1RAP, IL1RL1, ITGA1, JMJD6, LDLR, LGALS3BP, LITAF, LRP1, MAP3K4, NPC1, NR3C1, NR4A1, NR4A3, OSMR, P2RX4, PDGFRB, PDGFRL, PLAUR, PLK3, PPARD, PTPRE, RAMP1, RAPGEF2, RGS2, RGS3, SCARB1, SECTM1, SHB, SKIL, TGFBR1, THBD, TICAM1, TP53BP2, TRAF3, VDR	798	molecular transducer activity
GO:0008083	1.599e-04	3.137	15 AREG, BMP2, BMP6, CXCL1, ERAP1, FGF1, FGF7, GRN, HBEGF, IL11, IL6, LIF, PDGFA, PDGFD, VEGFA	94	growth factor activity
GO:0005102	2.120e-04	13.61	34 ANGPTL2, ANGPTL4, AREG, BMP2, BMP6, CCL2, CCL7, CXCL1, CXCL2, CXCL6, ERAP1, FEM1B, FGF1, FGF7, GPNMB, GRN, HBEGF, ICAM1, IL11, IL6, IL8, LIF, MFAP4, MTSS1, NAMPT, P2RX4, PDGFA, PDGFD, PDGFRB, PTHLH, SECTM1, TGFBR1, TNFSF4, VEGFA	408	receptor binding
GO:0008009	1.182e-03	0.5005	6 CCL2, CCL7, CXCL1, CXCL2, CXCL6, IL8	15	chemokine activity
GO:0042379	1.182e-03	0.5005	6 CCL2, CCL7, CXCL1, CXCL2, CXCL6, IL8	15	chemokine receptor binding
GO:0004872	1.311e-03	17.79	38 ADIPOR2, ADRA2A, BMPR2, CCRL1, CORIN, CXCR7, FCGRT, GPR183, GPR37, HBEGF, HLA-C, HLA-E, HLA-F, HTR2A, ICAM1, IL1RAP, IL1RL1, ITGA1, JMJD6, LDLR, LGALS3BP, LRP1, NPC1, NR3C1, NR4A1, NR4A3, OSMR, P2RX4, PDGFRB, PDGFRL, PLAUR, PPARD, PTPRE, RAMP1, SCARB1, TGFBR1, THBD, VDR	533	receptor activity
GO:0016564	3.259e-03	5.806	18 ARID5A, BHLHE40, BMP2, CREG1, HMGB2, JARID2, JUNB, LMCD1, MSC, NAB1, NFIL3, NFKB1, RELB, SKIL, TBX3, TRIM22, WWTR1, ZNF282	174	transcription repressor activity
GO:0004888	2.754e-02	11.14	24 ADRA2A, BMPR2, CCRL1, CORIN, CXCR7, GPR183, GPR37, HLA-C, HLA-E, HLA-F, HTR2A, ICAM1, IL1RAP, IL1RL1, LDLR, LGALS3BP, NPC1, OSMR, P2RX4, PDGFRB, PDGFRL, PTPRE, TGFBR1, THBD	334	transmembrane receptor activity
GO:0001664	3.284e-02	1.001	6 CCL2, CCL7, CXCL1, CXCL2, CXCL6, IL8	30	G-protein-coupled receptor binding
GO:0004252	3.479e-02	1.835	8 C1R, C1RL, C1S, CORIN, DPP4, F10, SERPINB2, TPP1	55	serine-type endopeptidase activity
GO:0005539	4.473e-02	1.935	8 CCL7, CXCL6, FGF1, GPNMB, HBEGF, SOD3, TNFAIP6, VEGFA	58	glycosaminoglycan binding
GO:0030247	4.833e-02	1.969	8 CCL7, CXCL6, FGF1, GPNMB, HBEGF, SOD3, TNFAIP6, VEGFA	59	polysaccharide binding

Id	Pvalue	ExpCount	Count	Size	Term
04060	2.177e-04	5.505	19 BMP2, BMPR2, CCL2, CCL7, CXCL1, CXCL2, CXCL3, CXCL6, IL11, IL1RAP, IL6, IL8, LIF, OSMR, PDGFA, PDGFRB, TGFBR1, TNFSF4, VEGFA	122	Cytokine-cytokine receptor interaction
04610	8.821e-03	1.534	8 C1R, C1S, CD55, F10, F3, PLAUR, PROS1, THBD	34	Complement and coagulation cascades

No enriched terms

No enriched terms

Entrez genes

ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (209612_s_at), score: 0.6 ADIPOR2adiponectin receptor 2 (201346_at), score: 0.46 ADRA2Aadrenergic, alpha-2A-, receptor (209869_at), score: 0.49 AEBP1AE binding protein 1 (201792_at), score: 0.39 ANGPTL2angiopoietin-like 2 (213001_at), score: 0.42 ANGPTL4angiopoietin-like 4 (221009_s_at), score: 0.9 ANK2ankyrin 2, neuronal (202920_at), score: 0.69 APODapolipoprotein D (201525_at), score: 0.46 AQP3aquaporin 3 (Gill blood group) (39248_at), score: 0.5 AREGamphiregulin (205239_at), score: 0.43 ARID5AAT rich interactive domain 5A (MRF1-like) (213138_at), score: 0.57 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: 0.42 ATP13A3ATPase type 13A3 (219558_at), score: 0.44 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (212361_s_at), score: 0.41 B3GNT2UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 (219326_s_at), score: 0.5 BBS1Bardet-Biedl syndrome 1 (218471_s_at), score: 0.42 BCL7AB-cell CLL/lymphoma 7A (203795_s_at), score: 0.46 BHLHE40basic helix-loop-helix family, member e40 (201170_s_at), score: 0.45 BMP2bone morphogenetic protein 2 (205289_at), score: 0.68 BMP6bone morphogenetic protein 6 (206176_at), score: 0.38 BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) (210214_s_at), score: 0.41 C13orf15chromosome 13 open reading frame 15 (218723_s_at), score: 0.42 C17orf91chromosome 17 open reading frame 91 (214696_at), score: 0.61 C19orf28chromosome 19 open reading frame 28 (220178_at), score: 0.41 C1Rcomplement component 1, r subcomponent (212067_s_at), score: 0.67 C1RLcomplement component 1, r subcomponent-like (218983_at), score: 0.51 C1Scomplement component 1, s subcomponent (208747_s_at), score: 0.54 C21orf45chromosome 21 open reading frame 45 (219004_s_at), score: -0.94 C4orf18chromosome 4 open reading frame 18 (219872_at), score: 0.58 CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (211368_s_at), score: 0.51 CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b (209682_at), score: 0.4 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: 0.7 CCL7chemokine (C-C motif) ligand 7 (208075_s_at), score: 0.52 CCNJcyclin J (219470_x_at), score: 0.44 CCRL1chemokine (C-C motif) receptor-like 1 (220351_at), score: 0.44 CD302CD302 molecule (203799_at), score: 0.66 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: 0.38 CDK2cyclin-dependent kinase 2 (204252_at), score: -0.96 CDYLchromodomain protein, Y-like (203100_s_at), score: 0.44 CENPMcentromere protein M (218741_at), score: -0.91 CHAF1Achromatin assembly factor 1, subunit A (p150) (214426_x_at), score: -0.93 CHAF1Bchromatin assembly factor 1, subunit B (p60) (204775_at), score: -0.91 CHST2carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 (203921_at), score: 0.46 CKAP2cytoskeleton associated protein 2 (218252_at), score: -0.96 CLIP3CAP-GLY domain containing linker protein 3 (212358_at), score: 0.38 CLUclusterin (208791_at), score: 0.47 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: 0.64 COL15A1collagen, type XV, alpha 1 (203477_at), score: 0.82 CORINcorin, serine peptidase (220356_at), score: 0.41 CPA3carboxypeptidase A3 (mast cell) (205624_at), score: 0.52 CPZcarboxypeptidase Z (211062_s_at), score: 0.44 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: 0.65 CRISPLD2cysteine-rich secretory protein LCCL domain containing 2 (221541_at), score: 0.52 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: 0.39 CTSDcathepsin D (200766_at), score: 0.47 CTSOcathepsin O (203758_at), score: 0.46 CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (204470_at), score: 0.52 CXCL2chemokine (C-X-C motif) ligand 2 (209774_x_at), score: 0.51 CXCL3chemokine (C-X-C motif) ligand 3 (207850_at), score: 0.71 CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) (206336_at), score: 0.44 CXCR7chemokine (C-X-C motif) receptor 7 (212977_at), score: 0.52 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: 0.57 DAAM2dishevelled associated activator of morphogenesis 2 (212793_at), score: 0.45 DCNdecorin (211896_s_at), score: 0.47 DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae) (218508_at), score: 0.46 DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked (205000_at), score: 0.41 DHCR77-dehydrocholesterol reductase (201790_s_at), score: 0.52 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: 0.79 DNASE2deoxyribonuclease II, lysosomal (214992_s_at), score: 0.42 DOCK1dedicator of cytokinesis 1 (203187_at), score: 0.4 DOCK9dedicator of cytokinesis 9 (212538_at), score: 0.42 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: 0.71 DRAMdamage-regulated autophagy modulator (218627_at), score: 0.55 DUSP5dual specificity phosphatase 5 (209457_at), score: 0.49 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: 0.62 EGR3early growth response 3 (206115_at), score: 0.67 ENTPD7ectonucleoside triphosphate diphosphohydrolase 7 (220153_at), score: 0.53 ERAP1endoplasmic reticulum aminopeptidase 1 (214012_at), score: 0.43 ERCC6Lexcision repair cross-complementing rodent repair deficiency, complementation group 6-like (219650_at), score: -0.91 EXOSC9exosome component 9 (205061_s_at), score: -0.91 F10coagulation factor X (205620_at), score: 0.59 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: 0.51 FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) (214285_at), score: 0.5 FADS1fatty acid desaturase 1 (208962_s_at), score: 0.38 FANCGFanconi anemia, complementation group G (203564_at), score: -0.94 FBXW7F-box and WD repeat domain containing 7 (218751_s_at), score: 0.64 FCGRTFc fragment of IgG, receptor, transporter, alpha (218831_s_at), score: 0.56 FEM1Bfem-1 homolog b (C. elegans) (212367_at), score: 0.48 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: 0.53 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: 0.66 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: 0.91 FOXO3forkhead box O3 (204132_s_at), score: 0.48 FOXO3Bforkhead box O3B pseudogene (210655_s_at), score: 0.55 FRYfurry homolog (Drosophila) (204072_s_at), score: 0.39 GAAglucosidase, alpha; acid (202812_at), score: 0.52 GABARAPL1GABA(A) receptor-associated protein like 1 (208868_s_at), score: 0.47 GALNAC4S-6STB cell RAG associated protein (203066_at), score: 0.46 GCH1GTP cyclohydrolase 1 (204224_s_at), score: 0.67 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: 0.77 GFPT2glutamine-fructose-6-phosphate transaminase 2 (205100_at), score: 0.55 GINS1GINS complex subunit 1 (Psf1 homolog) (206102_at), score: -0.96 GINS2GINS complex subunit 2 (Psf2 homolog) (221521_s_at), score: -0.95 GMNNgeminin, DNA replication inhibitor (218350_s_at), score: -0.93 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: 0.46 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: 0.71 GPR183G protein-coupled receptor 183 (205419_at), score: 0.57 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: 0.49 GRNgranulin (211284_s_at), score: 0.44 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: 0.54 GSTM2glutathione S-transferase mu 2 (muscle) (204418_x_at), score: 0.38 HBEGFheparin-binding EGF-like growth factor (203821_at), score: 0.74 HIPK3homeodomain interacting protein kinase 3 (210148_at), score: 0.43 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: 0.66 HIVEP2human immunodeficiency virus type I enhancer binding protein 2 (212642_s_at), score: 0.54 HK2hexokinase 2 (202934_at), score: 0.5 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: 0.42 HLA-Emajor histocompatibility complex, class I, E (200904_at), score: 0.46 HLA-Fmajor histocompatibility complex, class I, F (204806_x_at), score: 0.39 HLXH2.0-like homeobox (214438_at), score: 0.57 HMGB2high-mobility group box 2 (208808_s_at), score: -1 HMGCS13-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) (221750_at), score: 0.49 HMGN1high-mobility group nucleosome binding domain 1 (200944_s_at), score: -0.93 HMGN2high-mobility group nucleosomal binding domain 2 (208668_x_at), score: -0.94 HMOX1heme oxygenase (decycling) 1 (203665_at), score: 0.54 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: 0.45 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: 0.84 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: 0.63 IDUAiduronidase, alpha-L- (205059_s_at), score: 0.39 IFITM1interferon induced transmembrane protein 1 (9-27) (214022_s_at), score: 0.41 IL11interleukin 11 (206924_at), score: 0.62 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: 0.63 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: 0.65 IL6interleukin 6 (interferon, beta 2) (205207_at), score: 0.97 IL8interleukin 8 (202859_x_at), score: 0.72 INSIG1insulin induced gene 1 (201627_s_at), score: 0.74 ITGA1integrin, alpha 1 (214660_at), score: 0.5 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: 0.61 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: 0.75 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: 0.91 JMJD6jumonji domain containing 6 (212722_s_at), score: 0.43 JUNBjun B proto-oncogene (201473_at), score: 0.45 JUNDjun D proto-oncogene (203751_x_at), score: 0.61 KIAA0247KIAA0247 (202181_at), score: 0.62 KIAA1024KIAA1024 (215081_at), score: 0.47 KIAA1644KIAA1644 (52837_at), score: 0.5 KLHL21kelch-like 21 (Drosophila) (203068_at), score: 0.45 LDLRlow density lipoprotein receptor (202068_s_at), score: 0.52 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: 0.39 LHFPlipoma HMGIC fusion partner (218656_s_at), score: 0.53 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: 0.83 LITAFlipopolysaccharide-induced TNF factor (200706_s_at), score: 0.37 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: 0.47 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.87 LMNB1lamin B1 (203276_at), score: -0.91 LOH3CR2Aloss of heterozygosity, 3, chromosomal region 2, gene A (220244_at), score: 0.63 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: 0.64 LRP1low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) (200784_s_at), score: 0.46 MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast) (203362_s_at), score: -1 MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (209348_s_at), score: 0.45 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: 0.44 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: 0.78 MAP3K4mitogen-activated protein kinase kinase kinase 4 (216199_s_at), score: 0.42 MCM2minichromosome maintenance complex component 2 (202107_s_at), score: -0.91 MCM5minichromosome maintenance complex component 5 (216237_s_at), score: -0.94 MCM6minichromosome maintenance complex component 6 (201930_at), score: -0.91 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: 0.51 MFAP4microfibrillar-associated protein 4 (212713_at), score: 0.74 MLXIPMLX interacting protein (202519_at), score: 0.4 MSCmusculin (activated B-cell factor-1) (209928_s_at), score: 0.57 MTSS1metastasis suppressor 1 (203037_s_at), score: 0.7 MYO1Dmyosin ID (212338_at), score: 0.58 NAB1NGFI-A binding protein 1 (EGR1 binding protein 1) (208047_s_at), score: 0.39 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: 0.72 NEDD9neural precursor cell expressed, developmentally down-regulated 9 (202149_at), score: 0.48 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: 0.87 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: 0.66 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: 0.77 NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) (207535_s_at), score: 0.41 NID1nidogen 1 (202008_s_at), score: 0.4 NINJ1ninjurin 1 (203045_at), score: 0.72 NPC1Niemann-Pick disease, type C1 (202679_at), score: 0.38 NPC2Niemann-Pick disease, type C2 (200701_at), score: 0.39 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: 0.55 NR4A1nuclear receptor subfamily 4, group A, member 1 (202340_x_at), score: 0.51 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: 0.91 NUSAP1nucleolar and spindle associated protein 1 (218039_at), score: -0.9 OLFML2Aolfactomedin-like 2A (213075_at), score: 0.63 ORC6Lorigin recognition complex, subunit 6 like (yeast) (219105_x_at), score: -0.93 OSMRoncostatin M receptor (205729_at), score: 0.4 P2RX4purinergic receptor P2X, ligand-gated ion channel, 4 (204088_at), score: 0.38 PANX1pannexin 1 (204715_at), score: 0.42 PCTK2PCTAIRE protein kinase 2 (221918_at), score: 0.43 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: 0.67 PDGFDplatelet derived growth factor D (219304_s_at), score: 0.71 PDGFRBplatelet-derived growth factor receptor, beta polypeptide (202273_at), score: 0.51 PDGFRLplatelet-derived growth factor receptor-like (205226_at), score: 0.54 PDLIM3PDZ and LIM domain 3 (209621_s_at), score: 0.42 PIGBphosphatidylinositol glycan anchor biosynthesis, class B (214151_s_at), score: 0.48 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: 0.59 PLA2G4Cphospholipase A2, group IVC (cytosolic, calcium-independent) (209785_s_at), score: 0.45 PLAURplasminogen activator, urokinase receptor (211924_s_at), score: 0.41 PLK3polo-like kinase 3 (Drosophila) (204958_at), score: 0.44 PLSCR4phospholipid scramblase 4 (218901_at), score: 0.61 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: 0.93 POLR1Cpolymerase (RNA) I polypeptide C, 30kDa (207515_s_at), score: 0.45 PPAP2Aphosphatidic acid phosphatase type 2A (209147_s_at), score: 0.39 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: 0.54 PPLperiplakin (203407_at), score: 0.75 PRELPproline/arginine-rich end leucine-rich repeat protein (204223_at), score: 0.42 PRKG1protein kinase, cGMP-dependent, type I (207119_at), score: 0.45 PROS1protein S (alpha) (207808_s_at), score: 0.5 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: 0.55 PTHLHparathyroid hormone-like hormone (211756_at), score: 0.47 PTPREprotein tyrosine phosphatase, receptor type, E (221840_at), score: 0.52 RAB33ARAB33A, member RAS oncogene family (206039_at), score: 0.41 RACGAP1Rac GTPase activating protein 1 (222077_s_at), score: -0.93 RAD51AP1RAD51 associated protein 1 (204146_at), score: -0.9 RAMP1receptor (G protein-coupled) activity modifying protein 1 (204916_at), score: 0.39 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: 0.42 RCAN2regulator of calcineurin 2 (203498_at), score: 0.66 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: 0.47 RELBv-rel reticuloendotheliosis viral oncogene homolog B (205205_at), score: 0.54 RFC3replication factor C (activator 1) 3, 38kDa (204127_at), score: -0.96 RFC4replication factor C (activator 1) 4, 37kDa (204023_at), score: -0.99 RGPD5RANBP2-like and GRIP domain containing 5 (210676_x_at), score: 0.41 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: 0.55 RGS3regulator of G-protein signaling 3 (203823_at), score: 0.48 RRADRas-related associated with diabetes (204803_s_at), score: 0.93 RUNX1runt-related transcription factor 1 (209360_s_at), score: 0.73 SC4MOLsterol-C4-methyl oxidase-like (209146_at), score: 0.5 SCARB1scavenger receptor class B, member 1 (201819_at), score: 0.46 SECTM1secreted and transmembrane 1 (213716_s_at), score: 0.42 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: 0.39 SERPINF1serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 (202283_at), score: 0.46 SHBSrc homology 2 domain containing adaptor protein B (204657_s_at), score: 0.59 SKILSKI-like oncogene (206675_s_at), score: 0.54 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: 0.77 SLC22A18solute carrier family 22, member 18 (204981_at), score: 0.39 SLC2A3P1solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1 (221751_at), score: 0.42 SLC39A8solute carrier family 39 (zinc transporter), member 8 (209267_s_at), score: 0.52 SLC46A3solute carrier family 46, member 3 (214719_at), score: 0.43 SMOXspermine oxidase (210357_s_at), score: 0.81 SOD2superoxide dismutase 2, mitochondrial (221477_s_at), score: 0.59 SOD3superoxide dismutase 3, extracellular (205236_x_at), score: 0.38 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: 0.62 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: 0.57 SPATA2Lspermatogenesis associated 2-like (214965_at), score: 0.5 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: 0.77 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: 0.61 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: 0.65 SPSB1splA/ryanodine receptor domain and SOCS box containing 1 (219677_at), score: 0.64 SQLEsqualene epoxidase (213562_s_at), score: 0.69 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: 0.54 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: 0.59 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: 0.64 STILSCL/TAL1 interrupting locus (205339_at), score: -0.94 STK38Lserine/threonine kinase 38 like (212572_at), score: 0.78 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: 0.74 TAPBPLTAP binding protein-like (218746_at), score: 0.43 TBX3T-box 3 (219682_s_at), score: 0.49 TGFBR1transforming growth factor, beta receptor 1 (206943_at), score: 0.57 THBDthrombomodulin (203887_s_at), score: 0.73 TICAM1toll-like receptor adaptor molecule 1 (213191_at), score: 0.43 TK1thymidine kinase 1, soluble (202338_at), score: -0.92 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: 0.59 TMEM39Atransmembrane protein 39A (218615_s_at), score: 0.48 TMEM41Btransmembrane protein 41B (212623_at), score: 0.64 TNFAIP2tumor necrosis factor, alpha-induced protein 2 (202510_s_at), score: 0.6 TNFAIP3tumor necrosis factor, alpha-induced protein 3 (202644_s_at), score: 0.49 TNFAIP6tumor necrosis factor, alpha-induced protein 6 (206026_s_at), score: 0.53 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: 0.56 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: 0.58 TNS3tensin 3 (217853_at), score: 0.58 TNXAtenascin XA pseudogene (213451_x_at), score: 0.49 TNXBtenascin XB (216333_x_at), score: 0.55 TOM1target of myb1 (chicken) (202807_s_at), score: 0.48 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: 0.56 TP53I11tumor protein p53 inducible protein 11 (214667_s_at), score: 0.5 TPP1tripeptidyl peptidase I (200742_s_at), score: 0.54 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: 0.48 TRAF3TNF receptor-associated factor 3 (221571_at), score: 0.45 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: 0.77 TRIM22tripartite motif-containing 22 (213293_s_at), score: 0.47 TRMT5TRM5 tRNA methyltransferase 5 homolog (S. cerevisiae) (221952_x_at), score: -0.97 TTC17tetratricopeptide repeat domain 17 (218972_at), score: 0.45 UBA7ubiquitin-like modifier activating enzyme 7 (203281_s_at), score: 0.45 VCLvinculin (200930_s_at), score: 0.46 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (204255_s_at), score: 0.51 VEGFAvascular endothelial growth factor A (211527_x_at), score: 0.76 WEE1WEE1 homolog (S. pombe) (212533_at), score: -0.92 WISP1WNT1 inducible signaling pathway protein 1 (206796_at), score: 0.38 WISP2WNT1 inducible signaling pathway protein 2 (205792_at), score: 0.47 WTAPWilms tumor 1 associated protein (210285_x_at), score: 0.4 WWTR1WW domain containing transcription regulator 1 (202132_at), score: 0.4 YRDCyrdC domain containing (E. coli) (218647_s_at), score: 0.59 ZNF282zinc finger protein 282 (212892_at), score: 0.39 ZNF35zinc finger protein 35 (206096_at), score: 0.61 ZNF672zinc finger protein 672 (218068_s_at), score: 0.52

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
1Twin.CEL	1	2	DS-twin	hgu133plus2	Down	DS-twin 1
5CTwin.CEL	5	2	DS-twin	hgu133plus2	Down	DS-twin 5
6Twin.CEL	6	2	DS-twin	hgu133plus2	none	DS-twin 6
2Twin.CEL	2	2	DS-twin	hgu133plus2	none	DS-twin 2
E-GEOD-3407-raw-cel-1437949557.cel	1	4	Cockayne	hgu133a	CS	eGFP
t21b 08-03.CEL	5	1	DS-CC	hgu133a	Down	DS-CC 5
t21d 08-03.CEL	7	1	DS-CC	hgu133a	Down	DS-CC 7
t21c 08-03.CEL	6	1	DS-CC	hgu133a	Down	DS-CC 6
E-TABM-263-raw-cel-1515485751.cel	6	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486271.cel	32	6	Cycle	hgu133a2	none	Cycle 1
9118_CNTL.CEL	11	8	WBS	hgu133plus2	none	WBS 1
E-TABM-263-raw-cel-1515486291.cel	33	6	Cycle	hgu133a2	none	Cycle 1
E-GEOD-4219-raw-cel-1311956418.cel	13	7	Sph-mono	hgu133plus2	none	Sph-mon 1
46A.CEL	1	3	DS-mosaic	hgu133plus2	none	DS-mosaic 1
E-TABM-263-raw-cel-1515486351.cel	36	6	Cycle	hgu133a2	none	Cycle 1
ctrl a 08-03.CEL	1	1	DS-CC	hgu133a	none	DS-CC 1
ctrl b 08-03.CEL	2	1	DS-CC	hgu133a	none	DS-CC 2
E-TABM-263-raw-cel-1515486331.cel	35	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515485851.cel	11	6	Cycle	hgu133a2	none	Cycle 1
E-TABM-263-raw-cel-1515486231.cel	30	6	Cycle	hgu133a2	none	Cycle 1