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skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

blood vessel development

The process whose specific outcome is the progression of the blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

cell activation

A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.

vasculature development

The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies).

antigen processing and presentation of peptide antigen via MHC class I

The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins during acute inflammatory response

Any process activating plasma proteins via proteolysis during an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

circulatory system process

A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.

heart process

A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

apoptosis

A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

proteolysis

The hydrolysis of a peptide bond or bonds within a protein.

cell motion

Any process involved in the controlled movement of a cell.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

calcium-mediated signaling

A series of molecular signals in which a cell uses calcium ions to convert an extracellular signal into a response.

intracellular signaling cascade

A series of reactions within the cell that occur as a result of a single trigger reaction or compound.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

blood circulation

The flow of blood through the body of an animal, enabling the transport of O2 and nutrients to the tissues and the removal of waste products.

regulation of heart contraction

Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cell death

The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

programmed cell death

Cell death resulting from activation of endogenous cellular processes.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

regulation of apoptosis

Any process that modulates the occurrence or rate of cell death by apoptosis.

cell migration

The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

antigen processing and presentation

The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

second-messenger-mediated signaling

A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

muscle cell proliferation

The expansion of a muscle cell population by cell division.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

locomotion

Self-propelled movement of a cell or organism from one location to another.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of locomotion

Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

negative regulation of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis.

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

antigen processing and presentation of peptide antigen

The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of behavior

Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

smooth muscle cell proliferation

The multiplication or reproduction of smooth muscle cells, resulting in the expansion of a cell population.

regulation of smooth muscle cell proliferation

Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

tissue remodeling

The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of behavior

Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

positive chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a higher concentration, in a concentration gradient of a specific chemical.

regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

regulation of positive chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

positive regulation of positive chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

negative regulation of developmental process

Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

localization of cell

Any process by which a cell is transported to, and/or maintained in, a specific location.

heart contraction

The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.

cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

This term is the most general term possible

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

positive regulation of locomotion

Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of developmental process

Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of developmental process

Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

signal transduction

The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

negative regulation of cellular process

Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

anatomical structure formation

The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cell death

The specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

negative regulation of developmental process

Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of developmental process

Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

positive regulation of locomotion

Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of behavior

Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

regulation of behavior

Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

cell motion

Any process involved in the controlled movement of a cell.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

cellular biopolymer metabolic process

The chemical reactions and pathways involving biopolymers, long, repeating chains of monomers found in nature, such as polysaccharides and proteins, as carried out by individual cells.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell motion

Any process that activates or increases the frequency, rate or extent of the movement of a cell.

regulation of signal transduction

Any process that modulates the frequency, rate or extent of signal transduction.

positive regulation of cell communication

Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

osteoblast differentiation

The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone.

regulation of cell differentiation

Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

negative regulation of programmed cell death

Any process that stops, prevents or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

positive regulation of cell differentiation

Any process that activates or increases the frequency, rate or extent of cell differentiation.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

ossification

The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

cell chemotaxis

The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell migration

Any process that activates or increases the frequency, rate or extent of cell migration.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

leukocyte chemotaxis

The movement of a leukocyte in response to an external stimulus.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of response to external stimulus

Any process that activates, maintains or increases the rate of a response to an external stimulus.

regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

positive regulation of behavior

Any process that activates or increases the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

regulation of chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

cellular protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

positive regulation of signal transduction

Any process that activates or increases the frequency, rate or extent of signal transduction.

regulation of apoptosis

Any process that modulates the occurrence or rate of cell death by apoptosis.

negative regulation of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis.

regulation of smooth muscle cell proliferation

Any process that modulates the frequency, rate or extent of smooth muscle cell proliferation.

negative regulation of apoptosis

Any process that stops, prevents or reduces the frequency, rate or extent of cell death by apoptosis.

heart contraction

The multicellular organismal process by which the heart decreases in volume in a characteristic way to propel blood through the body.

bone development

The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.

angiogenesis

Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.

positive regulation of positive chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

regulation of positive chemotaxis

Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

positive regulation of positive chemotaxis

Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

regulation of heart contraction

Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body.

blood vessel morphogenesis

The process by which the anatomical structures of blood vessels are generated and organized. Morphogenesis pertains to the creation of form. The blood vessel is the vasculature carrying blood.

activation of plasma proteins during acute inflammatory response

Any process activating plasma proteins via proteolysis during an acute inflammatory response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

lytic vacuole

A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

lysosome

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

cell surface

The external part of the cell wall and/or plasma membrane.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

identical protein binding

Interacting selectively with an identical protein or proteins.

MHC class I receptor activity

Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.

protein homodimerization activity

Interacting selectively with an identical protein to form a homodimer.

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

This term is the most general term possible

protein homodimerization activity

Interacting selectively with an identical protein to form a homodimer.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0009611	4.586e-09	9.467	35 ACVR1, C1R, C1RL, C1S, CCL2, CD46, CD55, CFH, CFHR1, CLU, EDN1, F10, FGF7, GAP43, GNA13, HBEGF, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, NFKB1, NINJ1, PDGFA, PLAUR, PPARD, PROS1, SCG2, SCN9A, SRF, TFPI, TGM2, TPST1	231	response to wounding
GO:0002376	1.269e-08	19.47	52 C1R, C1RL, C1S, CBFB, CCL2, CD46, CD55, CFH, CFHR1, CLU, CSF1, DNASE2, DPP4, EDN1, ERAP1, ERAP2, FAS, GEM, GPR183, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, HOXB7, ICAM1, IL11, IL1RAP, IL23A, IL6, IL6ST, IL8, ITGA1, JARID2, LIF, NFIL3, NFKB1, NP, PSMB8, PSMB9, RUNX1, SCG2, SHB, SOX4, TAPBPL, TNFSF4, TOB2, TPD52, TRIM22, VEGFA	475	immune system process
GO:0009605	3.314e-08	15.16	44 ACVR1, ADIPOR2, ARSA, BHLHE40, C1R, C1RL, C1S, CCL2, CD46, CD55, CDH13, CFH, CFHR1, CLU, EDN1, F10, FGF7, GAP43, GNA13, HBEGF, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, ITGA1, JMJD3, NFKB1, NINJ1, NPC1, NR4A3, PDGFA, PLAUR, PPARD, PROS1, SCG2, SCN9A, SLC10A3, SRF, TFPI, TGM2, TPST1, VEGFA	370	response to external stimulus
GO:0048518	3.452e-08	35.57	75 ABLIM3, ACVR1, ADRA2A, AGRN, ANGPTL4, BMPR2, C1R, C1RL, C1S, CASP1, CASP4, CBFB, CCL2, CD46, CD55, CDH13, CFH, CFHR1, CLU, CSF1, CSRNP2, ECM1, EDN1, ERAP1, FAS, FGF1, FGF7, FURIN, GCLC, HBEGF, HHEX, HMOX1, ICAM1, IL11, IL6, IL6ST, IL8, JUND, KCNN4, LIF, LITAF, LPAR1, LRP5, LTBR, MAP3K7IP2, NAMPT, NFKB1, NP, NR4A1, NR4A3, P2RX4, PCBD1, PDGFA, PPARD, RUNX1, SCG2, SLC9A1, SMAD7, SMURF1, SOX4, SOX9, SPHK1, SRF, TBX3, TGM2, TM2D1, TNFSF4, TNS3, TOB2, TP53BP2, TRAF3, VEGFA, VEGFB, WFS1, WWTR1	868	positive regulation of biological process
GO:0032502	3.751e-07	77.99	125 ACVR1, ADAM23, ADIPOR2, AGRN, ANGPTL4, ARSA, ATP2A2, BBS1, BMPR2, CASP1, CASP4, CBFB, CCL2, CDC42SE1, CDH13, CLU, COL15A1, COL18A1, CREG1, CSF1, CSRNP2, CST3, DCN, DGKD, DNASE2, DRAM, EDN1, EGR3, EPHA2, ERAP1, ESM1, FAS, FGF1, FGF7, FOSB, FURIN, GAA, GAP43, GCLC, GNA13, GNPTAB, GPNMB, HBEGF, HHEX, HIPK3, HMOX1, HOXB6, HOXB7, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JUND, LAMA5, LIF, LIMS1, LITAF, LPAR1, LRP1, LRP5, LTBR, MAP1S, MEIS1, MTSS1, NFKB1, NINJ1, NP, NR3C1, NR4A1, NR4A3, NRXN3, P2RX4, PDGFA, PDLIM3, PHLDA3, PIP5K1C, PPARD, RNF130, RPS4Y1, RTN1, RUNX1, SCG2, SCN9A, SEMA5A, SERPINB2, SETX, SFRP1, SGPP1, SHB, SLC30A1, SLC9A1, SMAD7, SMURF1, SOX4, SOX9, SPATA20, SPHK1, SPOCK1, SPRED2, SPRY2, SPRY4, SRF, SULF1, TBX3, TCTN1, TGM2, TM2D1, TNFAIP2, TNFRSF11B, TNS3, TOB2, TP53BP2, TPD52, TPP1, TRAF3, TRIM32, UTP3, VEGFA, VEGFB, WFS1, WWTR1	1903	developmental process
GO:0042127	8.007e-07	15.61	42 ADRA2A, BMPR2, CCL2, CDH13, CLU, COL18A1, CSF1, EDN1, FGF1, FGF7, GPNMB, HBEGF, HHEX, HMOX1, IFITM1, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, LIF, LRP5, NAMPT, NP, PDGFA, PPAP2A, RARRES3, SCG2, SOX4, SOX9, SPHK1, TBX3, TGM2, TNFSF4, TNS3, TOB2, TP53I11, TRIB1, VEGFA, VEGFB	381	regulation of cell proliferation
GO:0048513	1.104e-06	30.45	64 ACVR1, AGRN, ANGPTL4, ATP2A2, BBS1, BMPR2, CBFB, CCL2, CDH13, CLU, COL15A1, COL18A1, CSF1, CST3, DCN, DNASE2, EDN1, EGR3, ERAP1, FAS, FGF1, FGF7, GAA, GAP43, GNA13, GPNMB, HBEGF, HHEX, HMOX1, HOXB6, HOXB7, IDUA, IL11, IL6, IL8, JARID2, LIF, MAP1S, NFKB1, NINJ1, NP, NR3C1, NR4A3, PDLIM3, PPARD, RUNX1, SCG2, SEMA5A, SHB, SMURF1, SOX4, SOX9, SPHK1, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TNS3, TOB2, TPD52, VEGFA, WFS1	743	organ development
GO:0040012	1.267e-06	3.401	18 BBS1, CDH13, CSF1, EDN1, GNA13, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, LAMA5, PDGFA, SCG2, SMAD7, SPHK1, TRIB1, VEGFA	83	regulation of locomotion
GO:0032501	1.341e-06	67.54	111 ACSL1, ACVR1, ADAM23, ADRA2A, AGRN, ANGPTL4, ARSA, ATP2A2, BBS1, BHLHE40, BMPR2, CBFB, CCL2, CDH13, CLU, COL15A1, COL18A1, CREG1, CSF1, CST3, DCN, DES, DGKD, DNASE2, EDN1, EGR3, EPHA2, ERAP1, ERAP2, F10, FAS, FGF1, FGF7, FOSB, FURIN, GAA, GAP43, GCLC, GNA13, GPNMB, HBEGF, HHEX, HMOX1, HOXB6, HOXB7, IDUA, IL11, IL23A, IL6, IL6ST, IL8, JARID2, JUND, KCNN4, LAMA5, LIF, LRP1, LRP5, MAN2B1, MAP1S, MEIS1, NFKB1, NINJ1, NP, NR3C1, NR4A3, NRXN3, P2RX4, PDGFA, PDLIM3, PIP5K1C, PLAUR, PPARD, PROS1, RPS4Y1, RTN1, RUNX1, SCG2, SCN9A, SEMA5A, SFRP1, SHB, SLC19A2, SLC22A18, SLC30A1, SMAD7, SMURF1, SOX4, SOX9, SPATA20, SPHK1, SPOCK1, SPRED2, SPRY2, SPRY4, SRF, STBD1, TBX3, TCTN1, TFPI, TGM2, TNFAIP2, TNFRSF11B, TNS3, TOB2, TPD52, TPP1, UTP3, VEGFA, WFS1, WWTR1	1648	multicellular organismal process
GO:0002474	1.538e-06	0.6967	9 ERAP1, ERAP2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, TAPBPL	17	antigen processing and presentation of peptide antigen via MHC class I
GO:0007275	2.641e-06	52.62	92 ACVR1, ADAM23, AGRN, ANGPTL4, ARSA, ATP2A2, BBS1, BMPR2, CBFB, CCL2, CDH13, CLU, COL15A1, COL18A1, CREG1, CSF1, CST3, DCN, DGKD, DNASE2, EDN1, EGR3, EPHA2, ERAP1, FAS, FGF1, FGF7, FOSB, GAA, GAP43, GNA13, GPNMB, HBEGF, HHEX, HMOX1, HOXB6, HOXB7, IDUA, IL11, IL6, IL6ST, IL8, JARID2, JUND, LAMA5, LIF, LRP1, LRP5, MAP1S, MEIS1, NFKB1, NINJ1, NP, NR3C1, NR4A3, NRXN3, PDGFA, PDLIM3, PIP5K1C, PPARD, RPS4Y1, RTN1, RUNX1, SCG2, SCN9A, SEMA5A, SFRP1, SHB, SLC30A1, SMURF1, SOX4, SOX9, SPATA20, SPHK1, SPOCK1, SPRED2, SPRY2, SPRY4, SRF, TBX3, TCTN1, TGM2, TNFAIP2, TNFRSF11B, TNS3, TOB2, TPD52, TPP1, UTP3, VEGFA, WFS1, WWTR1	1284	multicellular organismal development
GO:0048870	3.022e-06	7.254	26 ACVR1, BBS1, CCL2, CDH13, CSF1, EDN1, GNA13, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, LAMA5, LRP5, PDGFA, PPAP2A, PPARD, SCG2, SMAD7, SPHK1, SRF, TNS3, TRIB1, VEGFA	177	cell motility
GO:0006928	3.136e-06	11.02	33 ACVR1, ADRA2A, BBS1, CCL2, CDH13, CSF1, EDN1, GAP43, GNA13, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, LAMA5, LRP5, MTSS1, NRXN3, PDGFA, PLAUR, PPAP2A, PPARD, SCG2, SEMA5A, SMAD7, SPHK1, SPOCK1, SRF, TNS3, TRIB1, VEGFA	269	cell motion
GO:0051674	3.136e-06	11.02	33 ACVR1, ADRA2A, BBS1, CCL2, CDH13, CSF1, EDN1, GAP43, GNA13, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, LAMA5, LRP5, MTSS1, NRXN3, PDGFA, PLAUR, PPAP2A, PPARD, SCG2, SEMA5A, SMAD7, SPHK1, SPOCK1, SRF, TNS3, TRIB1, VEGFA	269	localization of cell
GO:0048856	3.524e-06	50.53	89 ACVR1, ADAM23, ADIPOR2, AGRN, ANGPTL4, ARSA, ATP2A2, BBS1, BMPR2, CBFB, CCL2, CDC42SE1, CDH13, CLU, COL15A1, COL18A1, CSF1, CST3, DCN, DGKD, DNASE2, EDN1, EGR3, EPHA2, ERAP1, ESM1, FAS, FGF1, FGF7, GAA, GAP43, GNA13, GPNMB, HBEGF, HHEX, HMOX1, HOXB6, HOXB7, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JUND, LIF, LPAR1, LRP5, MAP1S, MTSS1, NFKB1, NINJ1, NP, NR3C1, NR4A3, NRXN3, PDLIM3, PHLDA3, PIP5K1C, PPARD, RTN1, RUNX1, SCG2, SEMA5A, SFRP1, SHB, SLC9A1, SMAD7, SMURF1, SOX4, SOX9, SPHK1, SPOCK1, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TNS3, TOB2, TPD52, TPP1, VEGFA, VEGFB, WFS1, WWTR1	1233	anatomical structure development
GO:0048583	5.411e-06	5.041	21 C1R, C1RL, C1S, CD46, CD55, CDH13, CFH, CFHR1, CLU, EDN1, ERAP1, HMOX1, ICAM1, IL6, IL6ST, IL8, NPC1, PDGFA, SCG2, TGM2, VEGFA	123	regulation of response to stimulus
GO:0016477	6.115e-06	7.008	25 ACVR1, CCL2, CDH13, CSF1, EDN1, GNA13, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, LAMA5, LRP5, PDGFA, PPAP2A, PPARD, SCG2, SMAD7, SPHK1, SRF, TNS3, TRIB1, VEGFA	171	cell migration
GO:0048514	6.202e-06	5.082	21 ACVR1, ANGPTL4, CDH13, COL15A1, CST3, EDN1, ERAP1, FGF1, GNA13, HHEX, HMOX1, IL6, IL8, SCG2, SEMA5A, SHB, SPHK1, SRF, TGM2, TNFAIP2, VEGFA	124	blood vessel morphogenesis
GO:0001525	8.075e-06	4.262	19 ACVR1, ANGPTL4, CDH13, COL15A1, EDN1, ERAP1, FGF1, GNA13, HHEX, HMOX1, IL6, IL8, SCG2, SEMA5A, SHB, SPHK1, SRF, TNFAIP2, VEGFA	104	angiogenesis
GO:0009887	1.015e-05	12.79	35 ACVR1, ANGPTL4, BBS1, CCL2, CDH13, COL15A1, COL18A1, CST3, DCN, EDN1, ERAP1, FGF1, GAA, GNA13, HHEX, HMOX1, HOXB6, HOXB7, IDUA, IL6, IL8, JARID2, NR4A3, SCG2, SEMA5A, SHB, SOX9, SPHK1, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, VEGFA	312	organ morphogenesis
GO:0008284	1.080e-05	7.745	26 ADRA2A, CCL2, CDH13, CLU, CSF1, EDN1, FGF1, FGF7, HBEGF, IL11, IL6, IL6ST, LIF, LRP5, NAMPT, NP, PDGFA, SCG2, SOX4, SPHK1, TBX3, TGM2, TNFSF4, TNS3, VEGFA, VEGFB	189	positive regulation of cell proliferation
GO:0048002	1.342e-05	0.8606	9 ERAP1, ERAP2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, TAPBPL	21	antigen processing and presentation of peptide antigen
GO:0048584	1.961e-05	2.828	15 C1R, C1RL, C1S, CD46, CD55, CDH13, CFH, CFHR1, CLU, IL6, IL6ST, IL8, SCG2, TGM2, VEGFA	69	positive regulation of response to stimulus
GO:0048731	1.965e-05	41.35	75 ACVR1, ADAM23, AGRN, ANGPTL4, ARSA, ATP2A2, BBS1, BMPR2, CBFB, CCL2, CDH13, CLU, COL15A1, COL18A1, CSF1, CST3, DCN, DNASE2, EDN1, EGR3, EPHA2, ERAP1, FAS, FGF1, FGF7, GAA, GAP43, GNA13, GPNMB, HBEGF, HHEX, HMOX1, HOXB6, HOXB7, IDUA, IL11, IL6, IL6ST, IL8, JARID2, JUND, LIF, MAP1S, NFKB1, NINJ1, NP, NR3C1, NR4A3, NRXN3, PDLIM3, PIP5K1C, PPARD, RTN1, RUNX1, SCG2, SEMA5A, SHB, SMURF1, SOX4, SOX9, SPHK1, SPOCK1, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TNS3, TOB2, TPD52, TPP1, VEGFA, WFS1, WWTR1	1009	system development
GO:0050793	2.116e-05	28.65	58 ACVR1, ADIPOR2, AGRN, ANGPTL4, BMPR2, CASP1, CASP4, CCL2, CDC42SE1, CDH13, CLU, CSF1, CST3, DGKD, EDN1, ERAP1, ESM1, FAS, FURIN, GCLC, GNA13, HHEX, HIPK3, HMOX1, IGFBP5, IGFBP7, IL6, IL6ST, JUND, LAMA5, LIF, NFKB1, NP, NR4A1, P2RX4, PPARD, RUNX1, SCG2, SERPINB2, SFRP1, SLC9A1, SMAD7, SMURF1, SOX4, SOX9, SPHK1, SRF, TBX3, TGM2, TM2D1, TNFRSF11B, TOB2, TP53BP2, TRAF3, VEGFA, VEGFB, WFS1, WWTR1	699	regulation of developmental process
GO:0006955	2.509e-05	12.09	33 C1R, C1RL, C1S, CCL2, CD46, CD55, CFH, CFHR1, CLU, ERAP1, ERAP2, FAS, GEM, GPR183, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, ICAM1, IL1RAP, IL23A, IL6, IL6ST, IL8, LIF, NFIL3, PSMB8, PSMB9, TNFSF4, TRIM22	295	immune response
GO:0008283	2.605e-05	23.15	50 ADRA2A, BMPR2, CCL2, CDH13, CLU, COL18A1, CREG1, CSF1, EDN1, FGF1, FGF7, FURIN, GPNMB, HBEGF, HHEX, HMOX1, IFITM1, IGFBP5, IGFBP7, IL11, IL23A, IL6, IL6ST, IL8, JARID2, LIF, LRP1, LRP5, NAMPT, NP, PDGFA, PDGFD, PPAP2A, PPARD, RARRES3, SCG2, SHB, SOX4, SOX9, SPHK1, SPOCK1, TBX3, TGM2, TNFSF4, TNS3, TOB2, TP53I11, TRIB1, VEGFA, VEGFB	565	cell proliferation
GO:0050896	2.638e-05	55.32	92 ACVR1, ADIPOR2, ADRA2A, ANGPTL4, ARSA, BBS1, BHLHE40, C1R, C1RL, C1S, CCL2, CD46, CD55, CDH13, CFH, CFHR1, CLU, CST3, DGKD, DNAJC4, DPP4, EDEM1, EDN1, ERAP1, ERAP2, F10, FAS, FGF7, FOSB, GAA, GAP43, GCLC, GEM, GNA13, GPR183, GPX3, H2BFS, HBEGF, HIST1H2BK, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, ICAM1, IFITM1, IL1RAP, IL23A, IL6, IL6ST, IL8, ITGA1, JMJD3, KCNN4, LGALS3BP, LIF, MAN2B1, MAP3K2, MAP3K4, NFIL3, NFKB1, NINJ1, NPC1, NR3C1, NR4A3, P2RX4, PCYT1A, PDGFA, PLAUR, PPARD, PROS1, PSMB8, PSMB9, SCG2, SCN9A, SETX, SLC10A3, SLC22A18, SLC9A1, SMAD7, SRF, TFPI, TGM2, TNFSF4, TP53I11, TPST1, TRIB1, TRIM22, VEGFA, WFS1	1350	response to stimulus
GO:0002541	2.891e-05	0.6967	8 C1R, C1RL, C1S, CD46, CD55, CFH, CFHR1, CLU	17	activation of plasma proteins during acute inflammatory response
GO:0006956	2.891e-05	0.6967	8 C1R, C1RL, C1S, CD46, CD55, CFH, CFHR1, CLU	17	complement activation
GO:0001568	3.163e-05	5.614	21 ACVR1, ANGPTL4, CDH13, COL15A1, CST3, EDN1, ERAP1, FGF1, GNA13, HHEX, HMOX1, IL6, IL8, SCG2, SEMA5A, SHB, SPHK1, SRF, TGM2, TNFAIP2, VEGFA	137	blood vessel development
GO:0002526	3.350e-05	1.516	11 ACVR1, C1R, C1RL, C1S, CD46, CD55, CFH, CFHR1, CLU, IL6, IL6ST	37	acute inflammatory response
GO:0009653	3.594e-05	28.4	57 ACVR1, ADIPOR2, ANGPTL4, BBS1, BMPR2, CCL2, CDC42SE1, CDH13, CLU, COL15A1, COL18A1, CST3, DCN, DGKD, EDN1, ERAP1, ESM1, FGF1, GAA, GAP43, GNA13, HHEX, HMOX1, HOXB6, HOXB7, IDUA, IGFBP5, IGFBP7, IL6, IL8, JARID2, LPAR1, LRP5, MAP1S, MTSS1, NINJ1, NR4A3, NRXN3, PHLDA3, PIP5K1C, SCG2, SEMA5A, SFRP1, SHB, SLC9A1, SMAD7, SOX9, SPHK1, SPRY2, SRF, TBX3, TGM2, TNFAIP2, TNFRSF11B, TPD52, VEGFA, VEGFB	693	anatomical structure morphogenesis
GO:0006959	3.679e-05	1.229	10 C1R, C1RL, C1S, CCL2, CD46, CD55, CFH, CFHR1, CLU, IL6	30	humoral immune response
GO:0001944	3.986e-05	5.696	21 ACVR1, ANGPTL4, CDH13, COL15A1, CST3, EDN1, ERAP1, FGF1, GNA13, HHEX, HMOX1, IL6, IL8, SCG2, SEMA5A, SHB, SPHK1, SRF, TGM2, TNFAIP2, VEGFA	139	vasculature development
GO:0048869	4.387e-05	33.77	64 ACVR1, ADIPOR2, AGRN, ANGPTL4, BBS1, BMPR2, CBFB, CDC42SE1, CDH13, CLU, COL15A1, CSF1, DGKD, DNASE2, EDN1, EPHA2, ERAP1, ESM1, FAS, FGF1, GAP43, GNA13, GNPTAB, GPNMB, HHEX, HOXB7, IDUA, IGFBP5, IGFBP7, IL11, IL6, IL6ST, JUND, LIF, LPAR1, MAP1S, MTSS1, NFKB1, NP, NRXN3, PIP5K1C, PPARD, RTN1, RUNX1, SEMA5A, SFRP1, SHB, SLC9A1, SMAD7, SMURF1, SOX4, SOX9, SPATA20, SPHK1, SPRY2, SRF, TBX3, TNFAIP2, TOB2, TPD52, TRIM32, VEGFA, VEGFB, WWTR1	824	cellular developmental process
GO:0006954	4.820e-05	6.27	22 ACVR1, C1R, C1RL, C1S, CCL2, CD46, CD55, CFH, CFHR1, CLU, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, NFKB1, SCG2, SCN9A, TGM2, TPST1	153	inflammatory response
GO:0051239	5.134e-05	13.11	34 ACVR1, AGRN, ANGPTL4, ATP2A2, BHLHE40, BMPR2, CSF1, CST3, DES, EDN1, ERAP1, FAS, FURIN, GAA, HBEGF, HHEX, HMOX1, IL6, IL6ST, JUND, LAMA5, LIF, NFKB1, NP, P2RX4, PDGFA, RUNX1, SMAD7, SMURF1, SPHK1, SRF, TBX3, TNFRSF11B, TOB2	320	regulation of multicellular organismal process
GO:0030334	5.632e-05	3.074	15 CDH13, CSF1, EDN1, GNA13, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, LAMA5, PDGFA, SMAD7, SPHK1, TRIB1, VEGFA	75	regulation of cell migration
GO:0006952	5.875e-05	10.78	30 ACVR1, C1R, C1RL, C1S, CCL2, CD46, CD55, CFH, CFHR1, CLU, CST3, ERAP1, H2BFS, HIST1H2BK, HLA-B, HLA-G, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, KCNN4, LGALS3BP, NFKB1, SCG2, SCN9A, TGM2, TPST1	263	defense response
GO:0019882	7.471e-05	1.639	11 ERAP1, ERAP2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, ICAM1, PSMB8, TAPBPL	40	antigen processing and presentation
GO:0048646	8.619e-05	5.983	21 ACVR1, ANGPTL4, BMPR2, CDH13, COL15A1, EDN1, ERAP1, FGF1, GNA13, HHEX, HMOX1, IL6, IL8, NR4A3, SCG2, SEMA5A, SHB, SPHK1, SRF, TNFAIP2, VEGFA	146	anatomical structure formation
GO:0040011	1.071e-04	9.344	27 ACVR1, BBS1, CCL2, CDH13, CSF1, EDN1, GNA13, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, IL8, ITGA1, LAMA5, LRP5, PDGFA, PLAUR, PPAP2A, PPARD, SCG2, SMAD7, SPHK1, SRF, TNS3, TRIB1, VEGFA	228	locomotion
GO:0051270	1.142e-04	3.688	16 BBS1, CDH13, CSF1, EDN1, GNA13, HBEGF, HMOX1, ICAM1, IGFBP5, IL6, LAMA5, PDGFA, SMAD7, SPHK1, TRIB1, VEGFA	90	regulation of cell motion
GO:0002682	1.177e-04	6.106	21 C1R, C1RL, C1S, CD46, CD55, CFH, CFHR1, CLU, CSF1, ERAP1, FAS, HMOX1, ICAM1, IL6, IL6ST, LIF, NFKB1, NP, RUNX1, TOB2, VEGFA	149	regulation of immune system process
GO:0048522	1.992e-04	33.07	61 ABLIM3, ACVR1, ADRA2A, AGRN, BMPR2, CASP1, CASP4, CBFB, CCL2, CDH13, CLU, CSF1, CSRNP2, ECM1, EDN1, FAS, FGF1, FGF7, FURIN, GCLC, HBEGF, HHEX, HMOX1, ICAM1, IL11, IL6, IL6ST, JUND, LIF, LITAF, LPAR1, LRP5, LTBR, MAP3K7IP2, NAMPT, NFKB1, NP, NR4A1, NR4A3, P2RX4, PCBD1, PDGFA, PPARD, RUNX1, SCG2, SMAD7, SMURF1, SOX4, SOX9, SPHK1, SRF, TBX3, TGM2, TM2D1, TNFSF4, TNS3, TP53BP2, TRAF3, VEGFA, VEGFB, WWTR1	807	positive regulation of cellular process
GO:0050900	3.323e-04	1.229	9 CCL2, EDN1, HMOX1, ICAM1, IL6, IL8, ITGA1, SCG2, VEGFA	30	leukocyte migration
GO:0042060	5.800e-04	3.279	14 EDN1, F10, GAP43, GNA13, HBEGF, HMOX1, IL6, NINJ1, PDGFA, PLAUR, PPARD, PROS1, SRF, TFPI	80	wound healing
GO:0030154	6.886e-04	27.62	52 ACVR1, AGRN, ANGPTL4, BBS1, BMPR2, CBFB, CLU, COL15A1, CSF1, DNASE2, EDN1, EPHA2, ERAP1, FAS, FGF1, GAP43, GNA13, GNPTAB, GPNMB, HHEX, HOXB7, IL11, IL6, IL6ST, JUND, LIF, MAP1S, NFKB1, NP, NRXN3, PIP5K1C, PPARD, RTN1, RUNX1, SEMA5A, SFRP1, SHB, SLC9A1, SMAD7, SMURF1, SOX4, SOX9, SPATA20, SPRY2, SRF, TBX3, TNFAIP2, TOB2, TPD52, TRIM32, VEGFA, WWTR1	674	cell differentiation
GO:0051093	9.853e-04	11.88	29 ACVR1, ANGPTL4, CCL2, CDH13, CLU, CST3, FAS, FURIN, GCLC, HHEX, HIPK3, HMOX1, IL6, IL6ST, NFKB1, SCG2, SERPINB2, SFRP1, SLC9A1, SMAD7, SMURF1, SOX4, SPHK1, TBX3, TNFRSF11B, TOB2, VEGFA, WFS1, WWTR1	290	negative regulation of developmental process
GO:0050776	1.128e-03	3.033	13 C1R, C1RL, C1S, CD46, CD55, CFH, CFHR1, CLU, ERAP1, HMOX1, ICAM1, IL6, IL6ST	74	regulation of immune response
GO:0043066	1.182e-03	8.319	23 ACVR1, ANGPTL4, CCL2, CDH13, CLU, FAS, FURIN, GCLC, HIPK3, HMOX1, IL6, IL6ST, NFKB1, SCG2, SERPINB2, SFRP1, SLC9A1, SMAD7, SOX4, SPHK1, TBX3, VEGFA, WFS1	203	negative regulation of apoptosis
GO:0048771	1.281e-03	2.213	11 ACVR1, BMPR2, CST3, IL23A, IL6, IL6ST, JUND, SMURF1, TGM2, TOB2, TPP1	54	tissue remodeling
GO:0006958	1.433e-03	0.5737	6 C1R, C1RL, C1S, CD46, CD55, CLU	14	complement activation, classical pathway
GO:0043069	1.467e-03	8.442	23 ACVR1, ANGPTL4, CCL2, CDH13, CLU, FAS, FURIN, GCLC, HIPK3, HMOX1, IL6, IL6ST, NFKB1, SCG2, SERPINB2, SFRP1, SLC9A1, SMAD7, SOX4, SPHK1, TBX3, VEGFA, WFS1	206	negative regulation of programmed cell death
GO:0001649	1.525e-03	1.147	8 ACVR1, BMPR2, CBFB, GPNMB, IL6, IL6ST, JUND, WWTR1	28	osteoblast differentiation
GO:0051241	1.713e-03	1.885	10 ATP2A2, BMPR2, CST3, EDN1, FURIN, HMOX1, IL6, P2RX4, PDGFA, SMURF1	46	negative regulation of multicellular organismal process
GO:0001775	1.719e-03	6.229	19 CBFB, CSF1, DPP4, EDN1, FAS, GNA13, HMOX1, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, NP, P2RX4, PDGFA, SHB, SOX4, TPD52	152	cell activation
GO:0048660	1.737e-03	0.8606	7 CDH13, EDN1, HBEGF, IGFBP5, IL6, TGM2, TRIB1	21	regulation of smooth muscle cell proliferation
GO:0002455	2.155e-03	0.6147	6 C1R, C1RL, C1S, CD46, CD55, CLU	15	humoral immune response mediated by circulating immunoglobulin
GO:0006950	2.175e-03	35.16	60 ACVR1, ADRA2A, ANGPTL4, C1R, C1RL, C1S, CCL2, CD46, CD55, CFH, CFHR1, CLU, CST3, DNAJC4, DPP4, EDEM1, EDN1, ERAP1, F10, FGF7, GAP43, GCLC, GNA13, GPX3, H2BFS, HBEGF, HIST1H2BK, HLA-B, HLA-G, HMOX1, IL1RAP, IL23A, IL6, IL6ST, IL8, JMJD3, KCNN4, LGALS3BP, MAP3K2, MAP3K4, NFKB1, NINJ1, NPC1, P2RX4, PDGFA, PLAUR, PPARD, PROS1, SCG2, SCN9A, SETX, SMAD7, SRF, TFPI, TGM2, TP53I11, TPST1, TRIB1, VEGFA, WFS1	858	response to stress
GO:0048659	2.328e-03	0.9016	7 CDH13, EDN1, HBEGF, IGFBP5, IL6, TGM2, TRIB1	22	smooth muscle cell proliferation
GO:0032879	2.340e-03	8.729	23 BBS1, CDH13, CSF1, DNAJC1, EDN1, GNA13, HBEGF, HMOX1, ICAM1, IGFBP5, IL11, IL6, KCNN4, LAMA5, LIF, NFKB1, P2RX4, PDGFA, SMAD7, SPHK1, TRIB1, VEGFA, WFS1	213	regulation of localization
GO:0065008	2.378e-03	26.76	49 ADIPOR2, AGRN, ATP2A2, BBS1, BMPR2, CCL2, CD55, CDC42SE1, DGKD, DNASE2, EDN1, ERAP1, ERAP2, ESM1, F10, FAS, FURIN, GAA, GCLC, GNA13, HMOX1, HOXB6, IDUA, IGFBP5, IGFBP7, IL11, IL6, KCNN4, LIF, LPAR1, NPC1, NPC2, NR3C1, P2RX4, PDGFA, PLAUR, PROS1, SLC30A1, SLC9A1, SMAD7, SPHK1, SRF, TBX3, TFPI, TGM2, TPP1, VEGFA, VEGFB, WFS1	653	regulation of biological quality
GO:0048519	2.487e-03	37.74	63 ACVR1, ADIPOR2, ANGPTL4, ARID5A, ATP2A2, BCL7A, BHLHE40, BMPR2, CCL2, CDH13, CLU, COL18A1, CST3, DNAJC1, EDN1, FAS, FOSB, FURIN, GCLC, GPNMB, HHEX, HIPK3, HMOX1, IFITM1, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JMJD3, LIF, LMCD1, MAF, MTSS1, NAB1, NFKB1, NPC1, P2RX4, PDGFA, PPAP2A, RARRES3, RGS2, SCG2, SERPINB2, SFRP1, SLC9A1, SMAD7, SMURF1, SOX4, SOX9, SPHK1, TBX3, TNFRSF11B, TOB2, TP53BP2, TP53I11, TRIB1, VEGFA, WFS1, WT1, WWTR1	921	negative regulation of biological process
GO:0030335	2.591e-03	1.598	9 CDH13, CSF1, EDN1, HBEGF, ICAM1, IL6, PDGFA, SPHK1, VEGFA	39	positive regulation of cell migration
GO:0044057	2.683e-03	3.319	13 ATP2A2, BHLHE40, BMPR2, DES, EDN1, GAA, HBEGF, HMOX1, IL6ST, P2RX4, SMAD7, SPHK1, SRF	81	regulation of system process
GO:0002684	3.014e-03	3.36	13 C1R, C1RL, C1S, CD46, CD55, CFH, CFHR1, CLU, ICAM1, IL6, IL6ST, NP, VEGFA	82	positive regulation of immune system process
GO:0032103	3.968e-03	0.9836	7 CDH13, IL6, IL6ST, IL8, SCG2, TGM2, VEGFA	24	positive regulation of response to external stimulus
GO:0045597	4.200e-03	3.483	13 ACVR1, BMPR2, CLU, CSF1, IL6, IL6ST, JUND, LIF, NFKB1, NP, PPARD, RUNX1, SRF	85	positive regulation of cell differentiation
GO:0030595	4.332e-03	0.6967	6 CCL2, EDN1, IL6, IL8, ITGA1, SCG2	17	leukocyte chemotaxis
GO:0060326	4.332e-03	0.6967	6 CCL2, EDN1, IL6, IL8, ITGA1, SCG2	17	cell chemotaxis
GO:0050918	4.405e-03	0.2459	4 CDH13, IL8, SCG2, VEGFA	6	positive chemotaxis
GO:0050926	4.405e-03	0.2459	4 CDH13, IL8, SCG2, VEGFA	6	regulation of positive chemotaxis
GO:0050927	4.405e-03	0.2459	4 CDH13, IL8, SCG2, VEGFA	6	positive regulation of positive chemotaxis
GO:0032101	4.446e-03	2.131	10 CDH13, EDN1, IL6, IL6ST, IL8, NPC1, PDGFA, SCG2, TGM2, VEGFA	52	regulation of response to external stimulus
GO:0048523	5.242e-03	35.61	59 ACVR1, ADIPOR2, ANGPTL4, ARID5A, BCL7A, BHLHE40, CCL2, CDH13, CLU, COL18A1, CST3, DNAJC1, EDN1, FAS, FOSB, FURIN, GCLC, GPNMB, HHEX, HIPK3, HMOX1, IFITM1, IGFBP5, IGFBP7, IL11, IL6, IL6ST, IL8, JARID2, JMJD3, LIF, LMCD1, MAF, MTSS1, NAB1, NFKB1, NPC1, PDGFA, PPAP2A, RARRES3, RGS2, SCG2, SERPINB2, SFRP1, SLC9A1, SMAD7, SMURF1, SOX4, SOX9, SPHK1, TBX3, TOB2, TP53BP2, TP53I11, TRIB1, VEGFA, WFS1, WT1, WWTR1	869	negative regulation of cellular process
GO:0009967	5.677e-03	5.737	17 CASP1, CDH13, ECM1, HMOX1, IL11, IL6, IL6ST, LIF, LITAF, LPAR1, LTBR, MAP3K7IP2, P2RX4, PPARD, SOX4, TGM2, VEGFA	140	positive regulation of signal transduction
GO:0045595	5.817e-03	7.5	20 ACVR1, AGRN, BMPR2, CLU, CSF1, EDN1, FAS, IL6, IL6ST, JUND, LIF, NFKB1, NP, PPARD, RUNX1, SMAD7, SRF, TBX3, TOB2, WWTR1	183	regulation of cell differentiation
GO:0051272	6.081e-03	1.803	9 CDH13, CSF1, EDN1, HBEGF, ICAM1, IL6, PDGFA, SPHK1, VEGFA	44	positive regulation of cell motion
GO:0008016	6.345e-03	1.066	7 ATP2A2, DES, EDN1, GAA, HBEGF, P2RX4, SMAD7	26	regulation of heart contraction
GO:0002253	6.679e-03	1.434	8 C1R, C1RL, C1S, CD46, CD55, CFH, CFHR1, CLU	35	activation of immune response
GO:0019722	7.707e-03	0.7786	6 CDH13, EDN1, IL8, P2RX4, RCAN2, SPHK1	19	calcium-mediated signaling
GO:0006915	7.714e-03	24.42	44 ACVR1, ANGPTL4, CASP1, CASP4, CCL2, CDH13, CLU, CSRNP2, DNASE2, DRAM, FAS, FURIN, GCLC, HIPK3, HMOX1, IL6, IL6ST, LITAF, LTBR, MAP1S, NFKB1, NR4A1, P2RX4, PPARD, RNF130, SCG2, SERPINB2, SFRP1, SGPP1, SHB, SLC9A1, SMAD7, SOX4, SOX9, SPHK1, SULF1, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA, WFS1	596	apoptosis
GO:0002252	8.580e-03	3.279	12 C1R, C1RL, C1S, CD46, CD55, CFH, CFHR1, CLU, FAS, HMOX1, ICAM1, IL6	80	immune effector process
GO:0002443	8.626e-03	2.336	10 C1R, C1RL, C1S, CD46, CD55, CLU, FAS, HMOX1, ICAM1, IL6	57	leukocyte mediated immunity
GO:0012501	9.009e-03	24.63	44 ACVR1, ANGPTL4, CASP1, CASP4, CCL2, CDH13, CLU, CSRNP2, DNASE2, DRAM, FAS, FURIN, GCLC, HIPK3, HMOX1, IL6, IL6ST, LITAF, LTBR, MAP1S, NFKB1, NR4A1, P2RX4, PPARD, RNF130, SCG2, SERPINB2, SFRP1, SGPP1, SHB, SLC9A1, SMAD7, SOX4, SOX9, SPHK1, SULF1, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA, WFS1	601	programmed cell death
GO:0016265	9.166e-03	26.19	46 ACVR1, ANGPTL4, CASP1, CASP4, CCL2, CDH13, CLU, CSRNP2, CST3, DNASE2, DRAM, FAS, FURIN, GCLC, HIPK3, HMOX1, IL6, IL6ST, LITAF, LTBR, MAP1S, NFKB1, NR4A1, P2RX4, PPARD, RNF130, SCG2, SERPINB2, SETX, SFRP1, SGPP1, SHB, SLC9A1, SMAD7, SOX4, SOX9, SPHK1, SULF1, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA, WFS1	639	death
GO:0040017	1.011e-02	0.5328	5 CDH13, IL6, IL8, SCG2, VEGFA	13	positive regulation of locomotion
GO:0048520	1.011e-02	0.5328	5 CDH13, IL6, IL8, SCG2, VEGFA	13	positive regulation of behavior
GO:0050920	1.011e-02	0.5328	5 CDH13, IL6, IL8, SCG2, VEGFA	13	regulation of chemotaxis
GO:0050921	1.011e-02	0.5328	5 CDH13, IL6, IL8, SCG2, VEGFA	13	positive regulation of chemotaxis
GO:0010647	1.060e-02	6.106	17 CASP1, CDH13, ECM1, HMOX1, IL11, IL6, IL6ST, LIF, LITAF, LPAR1, LTBR, MAP3K7IP2, P2RX4, PPARD, SOX4, TGM2, VEGFA	149	positive regulation of cell communication
GO:0050778	1.071e-02	1.967	9 C1R, C1RL, C1S, CD46, CD55, CFH, CFHR1, CLU, IL6ST	48	positive regulation of immune response
GO:0034103	1.090e-02	1.557	8 ACVR1, BMPR2, CST3, IL6, IL6ST, JUND, SMURF1, TOB2	38	regulation of tissue remodeling
GO:0050878	1.223e-02	2.459	10 EDN1, F10, GNA13, IL6, KCNN4, PDGFA, PLAUR, PROS1, TFPI, WFS1	60	regulation of body fluid levels
GO:0045321	1.223e-02	5.614	16 CBFB, CSF1, DPP4, EDN1, FAS, HMOX1, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, NP, SHB, SOX4, TPD52	137	leukocyte activation
GO:0007155	1.227e-02	15.41	31 ADAM23, AJAP1, ATP2A2, CCL2, CDH13, CLDN1, COL15A1, COL18A1, CSF1, DPP4, GPNMB, ICAM1, IGFBP7, IL8, ITGA1, LAMA5, LGALS3BP, MTSS1, NEDD9, NID1, NINJ1, NRXN3, PCDH7, PKP2, PPARD, SCARB1, SEMA5A, SMAD7, SOX9, SPOCK1, SVEP1	376	cell adhesion
GO:0022610	1.227e-02	15.41	31 ADAM23, AJAP1, ATP2A2, CCL2, CDH13, CLDN1, COL15A1, COL18A1, CSF1, DPP4, GPNMB, ICAM1, IGFBP7, IL8, ITGA1, LAMA5, LGALS3BP, MTSS1, NEDD9, NID1, NINJ1, NRXN3, PCDH7, PKP2, PPARD, SCARB1, SEMA5A, SMAD7, SOX9, SPOCK1, SVEP1	376	biological adhesion
GO:0046849	1.265e-02	1.598	8 ACVR1, BMPR2, IL6, IL6ST, JUND, SMURF1, TOB2, TPP1	39	bone remodeling
GO:0006916	1.307e-02	5.655	16 CCL2, CDH13, CLU, FAS, GCLC, HIPK3, HMOX1, IL6, IL6ST, NFKB1, SERPINB2, SFRP1, SLC9A1, SMAD7, SPHK1, TBX3	138	anti-apoptosis
GO:0007205	1.383e-02	0.5737	5 DGKD, EDN1, GAP43, PPAP2A, SPHK1	14	activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0045669	1.383e-02	0.5737	5 ACVR1, BMPR2, IL6, IL6ST, JUND	14	positive regulation of osteoblast differentiation
GO:0048661	1.383e-02	0.5737	5 CDH13, EDN1, HBEGF, IL6, TGM2	14	positive regulation of smooth muscle cell proliferation
GO:0050795	1.383e-02	0.5737	5 CDH13, IL6, IL8, SCG2, VEGFA	14	regulation of behavior
GO:0010740	1.385e-02	4.016	13 CASP1, ECM1, HMOX1, IL11, IL6, IL6ST, LIF, LITAF, LPAR1, LTBR, MAP3K7IP2, PPARD, TGM2	98	positive regulation of protein kinase cascade
GO:0008219	1.482e-02	26.11	45 ACVR1, ANGPTL4, CASP1, CASP4, CCL2, CDH13, CLU, CSRNP2, DNASE2, DRAM, FAS, FURIN, GCLC, HIPK3, HMOX1, IL6, IL6ST, LITAF, LTBR, MAP1S, NFKB1, NR4A1, P2RX4, PPARD, RNF130, SCG2, SERPINB2, SETX, SFRP1, SGPP1, SHB, SLC9A1, SMAD7, SOX4, SOX9, SPHK1, SULF1, TBX3, TGM2, TM2D1, TNFRSF11B, TP53BP2, TRAF3, VEGFA, WFS1	637	cell death
GO:0051094	1.554e-02	12.17	26 ACVR1, ANGPTL4, BMPR2, CASP4, CLU, CSF1, ERAP1, FAS, HMOX1, IL6, IL6ST, JUND, LIF, NFKB1, NP, NR4A1, PPARD, RUNX1, SOX4, SPHK1, SRF, TGM2, TM2D1, TOB2, TP53BP2, TRAF3	297	positive regulation of developmental process
GO:0033002	1.624e-02	1.27	7 CDH13, EDN1, HBEGF, IGFBP5, IL6, TGM2, TRIB1	31	muscle cell proliferation
GO:0045768	1.837e-02	0.6147	5 HMOX1, IL6, IL6ST, SLC9A1, SMAD7	15	positive regulation of anti-apoptosis
GO:0003015	1.911e-02	1.311	7 ATP2A2, DES, EDN1, GAA, HBEGF, P2RX4, SMAD7	32	heart process
GO:0030278	1.911e-02	1.311	7 ACVR1, BMPR2, IL6, IL6ST, JUND, SMURF1, TOB2	32	regulation of ossification
GO:0060047	1.911e-02	1.311	7 ATP2A2, DES, EDN1, GAA, HBEGF, P2RX4, SMAD7	32	heart contraction
GO:0033135	1.982e-02	0.1639	3 IL11, IL6, LIF	4	regulation of peptidyl-serine phosphorylation
GO:0033138	1.982e-02	0.1639	3 IL11, IL6, LIF	4	positive regulation of peptidyl-serine phosphorylation
GO:0050930	1.982e-02	0.1639	3 IL8, SCG2, VEGFA	4	induction of positive chemotaxis
GO:0045087	2.057e-02	2.664	10 C1R, C1RL, C1S, CD46, CD55, CFH, CLU, ERAP1, IL1RAP, IL23A	65	innate immune response
GO:0002685	2.156e-02	0.3688	4 HMOX1, ICAM1, IL6, VEGFA	9	regulation of leukocyte migration
GO:0001501	2.179e-02	6.598	17 ACVR1, BMPR2, CBFB, EDN1, GPNMB, HOXB6, HOXB7, IDUA, IL6, IL6ST, JUND, SMURF1, SOX9, TBX3, TNFRSF11B, TOB2, WWTR1	161	skeletal system development
GO:0003013	2.235e-02	3.729	12 ATP2A2, BMPR2, DES, EDN1, ERAP1, ERAP2, GAA, GCLC, HBEGF, HMOX1, P2RX4, SMAD7	91	circulatory system process
GO:0008015	2.235e-02	3.729	12 ATP2A2, BMPR2, DES, EDN1, ERAP1, ERAP2, GAA, GCLC, HBEGF, HMOX1, P2RX4, SMAD7	91	blood circulation
GO:0009893	2.284e-02	15.41	30 ABLIM3, ACVR1, AGRN, CBFB, CDH13, CSF1, CSRNP2, EDN1, FURIN, GCLC, HHEX, HMOX1, IL11, IL6, IL6ST, LIF, NFKB1, NR4A1, NR4A3, P2RX4, PCBD1, PDGFA, RUNX1, SMAD7, SMURF1, SOX4, SOX9, SRF, WFS1, WWTR1	376	positive regulation of metabolic process
GO:0001503	2.476e-02	2.746	10 ACVR1, BMPR2, CBFB, GPNMB, IL6, IL6ST, JUND, SMURF1, TOB2, WWTR1	67	ossification
GO:0060348	2.476e-02	2.746	10 ACVR1, BMPR2, CBFB, GPNMB, IL6, IL6ST, JUND, SMURF1, TOB2, WWTR1	67	bone development
GO:0007169	2.696e-02	6.147	16 AGRN, BMPR2, CCL2, CD3EAP, CDH13, DGKD, EPHA2, FGF1, FGF7, HBEGF, HHEX, IGFBP5, MTSS1, PDGFA, RGS2, VEGFA	150	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0045444	2.746e-02	1.025	6 BBS1, ERAP1, IL11, PPARD, TRIM32, WWTR1	25	fat cell differentiation
GO:0042981	2.883e-02	17.17	32 ACVR1, ANGPTL4, CASP1, CASP4, CCL2, CDH13, CLU, FAS, FURIN, GCLC, HIPK3, HMOX1, IL6, IL6ST, NFKB1, NR4A1, P2RX4, SCG2, SERPINB2, SFRP1, SLC9A1, SMAD7, SOX4, SOX9, SPHK1, TBX3, TGM2, TM2D1, TP53BP2, TRAF3, VEGFA, WFS1	419	regulation of apoptosis
GO:0046850	2.932e-02	1.434	7 ACVR1, BMPR2, IL6, IL6ST, JUND, SMURF1, TOB2	35	regulation of bone remodeling
GO:0006935	2.953e-02	2.828	10 CCL2, CDH13, EDN1, IL6, IL8, ITGA1, PDGFA, PLAUR, SCG2, VEGFA	69	chemotaxis
GO:0042330	2.953e-02	2.828	10 CCL2, CDH13, EDN1, IL6, IL8, ITGA1, PDGFA, PLAUR, SCG2, VEGFA	69	taxis
GO:0045767	2.969e-02	0.6967	5 HMOX1, IL6, IL6ST, SLC9A1, SMAD7	17	regulation of anti-apoptosis
GO:0022603	2.978e-02	8.77	20 ADIPOR2, ANGPTL4, CDC42SE1, CST3, DGKD, EDN1, ERAP1, ESM1, GNA13, HHEX, HMOX1, IGFBP5, IGFBP7, IL6, SLC9A1, SMAD7, SPHK1, TNFRSF11B, VEGFA, VEGFB	214	regulation of anatomical structure morphogenesis
GO:0001569	3.043e-02	0.4098	4 ACVR1, EDN1, GNA13, SEMA5A	10	patterning of blood vessels
GO:0001938	3.043e-02	0.4098	4 CCL2, CDH13, SCG2, VEGFA	10	positive regulation of endothelial cell proliferation
GO:0043500	3.043e-02	0.4098	4 EDN1, HMOX1, IL6ST, P2RX4	10	muscle adaptation
GO:0007167	3.201e-02	9.508	21 ACVR1, AGRN, BMPR2, CCL2, CD3EAP, CDH13, DGKD, EPHA2, FGF1, FGF7, HBEGF, HHEX, IGFBP5, IL6ST, LIF, MTSS1, PDGFA, RGS2, SMAD7, SMURF1, VEGFA	232	enzyme linked receptor protein signaling pathway
GO:0051260	3.215e-02	1.066	6 DGKD, FAS, GPX3, PCBD1, STOM, TGM2	26	protein homooligomerization
GO:0002250	3.244e-02	2.377	9 C1R, C1RL, C1S, CD46, CD55, CLU, FAS, ICAM1, IL6ST	58	adaptive immune response
GO:0000902	3.288e-02	12.99	26 ADIPOR2, BBS1, CDC42SE1, CDH13, CLU, DGKD, EDN1, ESM1, GAP43, GNA13, IDUA, IGFBP5, IGFBP7, IL6, LPAR1, MAP1S, MTSS1, NRXN3, PIP5K1C, SEMA5A, SLC9A1, SMAD7, SOX9, SPHK1, VEGFA, VEGFB	317	cell morphogenesis
GO:0032989	3.288e-02	12.99	26 ADIPOR2, BBS1, CDC42SE1, CDH13, CLU, DGKD, EDN1, ESM1, GAP43, GNA13, IDUA, IGFBP5, IGFBP7, IL6, LPAR1, MAP1S, MTSS1, NRXN3, PIP5K1C, SEMA5A, SLC9A1, SMAD7, SOX9, SPHK1, VEGFA, VEGFB	317	cellular structure morphogenesis
GO:0019724	3.325e-02	1.475	7 C1R, C1RL, C1S, CD46, CD55, CLU, FAS	36	B cell mediated immunity
GO:0043067	3.424e-02	17.42	32 ACVR1, ANGPTL4, CASP1, CASP4, CCL2, CDH13, CLU, FAS, FURIN, GCLC, HIPK3, HMOX1, IL6, IL6ST, NFKB1, NR4A1, P2RX4, SCG2, SERPINB2, SFRP1, SLC9A1, SMAD7, SOX4, SOX9, SPHK1, TBX3, TGM2, TM2D1, TP53BP2, TRAF3, VEGFA, WFS1	425	regulation of programmed cell death
GO:0045667	3.635e-02	0.7377	5 ACVR1, BMPR2, IL6, IL6ST, JUND	18	regulation of osteoblast differentiation
GO:0010611	3.728e-02	0.2049	3 EDN1, IL6ST, P2RX4	5	regulation of cardiac muscle hypertrophy
GO:0010612	3.728e-02	0.2049	3 EDN1, IL6ST, P2RX4	5	regulation of cardiac muscle adaptation
GO:0014743	3.728e-02	0.2049	3 EDN1, IL6ST, P2RX4	5	regulation of muscle hypertrophy
GO:0014887	3.728e-02	0.2049	3 EDN1, IL6ST, P2RX4	5	cardiac muscle adaptation
GO:0014888	3.728e-02	0.2049	3 EDN1, IL6ST, P2RX4	5	striated muscle adaptation
GO:0014897	3.728e-02	0.2049	3 EDN1, IL6ST, P2RX4	5	striated muscle hypertrophy
GO:0014898	3.728e-02	0.2049	3 EDN1, IL6ST, P2RX4	5	cardiac muscle hypertrophy
GO:0031330	3.728e-02	0.2049	3 CST3, FURIN, NPC1	5	negative regulation of cellular catabolic process
GO:0043502	3.728e-02	0.2049	3 EDN1, IL6ST, P2RX4	5	regulation of muscle adaptation
GO:0045933	3.728e-02	0.2049	3 EDN1, SPHK1, SRF	5	positive regulation of muscle contraction
GO:0045987	3.728e-02	0.2049	3 EDN1, SPHK1, SRF	5	positive regulation of smooth muscle contraction
GO:0048010	4.066e-02	0.4508	4 BMPR2, CCL2, HHEX, VEGFA	11	vascular endothelial growth factor receptor signaling pathway
GO:0010604	4.088e-02	14.71	28 ABLIM3, ACVR1, AGRN, CBFB, CDH13, CSF1, CSRNP2, FURIN, GCLC, HHEX, HMOX1, IL11, IL6, IL6ST, LIF, NFKB1, NR4A1, NR4A3, PCBD1, PDGFA, RUNX1, SMAD7, SMURF1, SOX4, SOX9, SRF, WFS1, WWTR1	359	positive regulation of macromolecule metabolic process
GO:0009966	4.103e-02	15.45	29 ACVR1, CASP1, CDH13, ECM1, EDN1, HHEX, HMOX1, IGFBP5, IL11, IL6, IL6ST, LIF, LITAF, LPAR1, LTBR, MAP3K7IP2, P2RX4, PPARD, RAMP1, RGS2, SMAD7, SMURF1, SOX4, SPRED2, SPRY2, SPRY4, TGM2, TRIB1, VEGFA	377	regulation of signal transduction
GO:0045944	4.433e-02	5.942	15 ABLIM3, AGRN, CBFB, CSRNP2, HHEX, IL11, IL6, LIF, NFKB1, NR4A1, NR4A3, RUNX1, SOX9, SRF, WWTR1	145	positive regulation of transcription from RNA polymerase II promoter
GO:0007596	4.541e-02	2.049	8 EDN1, F10, GNA13, IL6, PDGFA, PLAUR, PROS1, TFPI	50	blood coagulation
GO:0050817	4.541e-02	2.049	8 EDN1, F10, GNA13, IL6, PDGFA, PLAUR, PROS1, TFPI	50	coagulation
GO:0031325	4.694e-02	14.92	28 ABLIM3, ACVR1, AGRN, CBFB, CSF1, CSRNP2, EDN1, FURIN, GCLC, HHEX, HMOX1, IL11, IL6, IL6ST, LIF, NFKB1, NR4A1, NR4A3, P2RX4, PCBD1, PDGFA, RUNX1, SMAD7, SMURF1, SOX4, SOX9, SRF, WWTR1	364	positive regulation of cellular metabolic process
GO:0010646	4.851e-02	17.21	31 ACVR1, BHLHE40, CASP1, CDH13, ECM1, EDN1, HHEX, HMOX1, IGFBP5, IL11, IL6, IL6ST, LIF, LITAF, LPAR1, LTBR, MAP3K7IP2, NPC1, P2RX4, PPARD, RAMP1, RGS2, SMAD7, SMURF1, SOX4, SPRED2, SPRY2, SPRY4, TGM2, TRIB1, VEGFA	420	regulation of cell communication
GO:0003012	4.950e-02	3.115	10 DES, EDN1, GAA, HMOX1, IL6ST, P2RX4, SMAD7, SPHK1, SRF, STBD1	76	muscle system process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005576	3.097e-12	27.37	71 A2M, ADAM23, AGRN, ANGPTL4, ARSA, C1R, C1RL, C1S, CCL2, CDH13, CFH, CFHR1, CLU, COL15A1, COL18A1, CPZ, CREG1, CSF1, CST3, DCN, DPP4, ECM1, EDN1, ERAP1, F10, FAS, FGF1, FGF7, FURIN, GPX3, GRN, HBEGF, HLA-C, HMOX1, ICAM1, IGFBP5, IGFBP7, IL11, IL1RAP, IL23A, IL6, IL6ST, IL8, LAMA5, LGALS3BP, LIF, MAN2B2, MFAP4, NID1, NPC2, OLFML2A, PDGFA, PDGFD, PLAUR, PROS1, PTGDS, RNASET2, SCG2, SERPINB2, SFRP1, SPOCK1, ST3GAL1, SULF1, SVEP1, TCTN1, TFPI, TNFAIP2, TNFRSF11B, TNFSF4, VEGFA, VEGFB	700	extracellular region
GO:0044421	3.026e-09	15.13	45 A2M, AGRN, ANGPTL4, ARSA, C1RL, CCL2, CDH13, CFH, CFHR1, CLU, COL15A1, COL18A1, CPZ, CSF1, CST3, DCN, ECM1, EDN1, FGF1, FURIN, GPX3, GRN, HBEGF, HMOX1, ICAM1, IGFBP5, IL11, IL23A, IL6, IL8, LAMA5, LGALS3BP, LIF, MFAP4, NID1, OLFML2A, PDGFA, SCG2, SFRP1, SPOCK1, SULF1, TNFAIP2, TNFRSF11B, TNFSF4, VEGFA	387	extracellular region part
GO:0005615	3.775e-08	9.619	33 A2M, ANGPTL4, ARSA, C1RL, CCL2, CDH13, CFH, CFHR1, CLU, CSF1, CST3, EDN1, FGF1, FURIN, GPX3, GRN, HBEGF, HMOX1, ICAM1, IGFBP5, IL11, IL23A, IL6, IL8, LGALS3BP, LIF, PDGFA, SCG2, SFRP1, SULF1, TNFAIP2, TNFSF4, VEGFA	246	extracellular space
GO:0042612	5.798e-04	0.5865	6 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	15	MHC class I protein complex
GO:0000323	1.161e-03	4.379	15 ARSA, DNASE2, DRAM, GAA, GNS, IDS, IDUA, LITAF, MAN2B1, MANBA, MARCH2, NEU1, NPC1, NPC2, TPP1	112	lytic vacuole
GO:0005764	1.161e-03	4.379	15 ARSA, DNASE2, DRAM, GAA, GNS, IDS, IDUA, LITAF, MAN2B1, MANBA, MARCH2, NEU1, NPC1, NPC2, TPP1	112	lysosome
GO:0044459	2.291e-03	34.21	57 ACVR1, ADAM23, ADRA2A, AJAP1, ARSA, ATP2A2, BMPR2, CADPS2, CD46, CD55, CDH13, CLDN1, DPP4, EPHA2, FAS, GAP43, GPNMB, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, ICAM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, KCTD13, LIMS1, LPAR1, LRP1, MAGI2, NEDD9, NPC1, NRXN3, P2RX4, PCDH7, PKP2, PPAP2A, RAMP1, SCN9A, SLC20A2, SLC22A18, SLC9A1, SLC9A3R2, ST3GAL5, STBD1, STOM, SYNGR2, TM2D1, TNFSF4, TNS3	875	plasma membrane part
GO:0042611	5.028e-03	0.8602	6 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	22	MHC protein complex
GO:0005886	5.202e-03	56.42	82 ACVR1, ADAM23, ADRA2A, AJAP1, ARSA, ATP2A2, BBS1, BMPR2, CADPS2, CD46, CD55, CDC42SE1, CDH13, CLDN1, CSF1, DDX3Y, DES, DGKD, DPP4, EPHA2, F10, FAS, FURIN, GAP43, GEM, GPNMB, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, ICAM1, IFITM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, KCTD13, LIMS1, LPAR1, LRP1, LYN, MAGI2, NEDD9, NEU1, NPC1, NRXN3, P2RX4, PCDH7, PIP5K1C, PKP2, PLAUR, PMEPA1, PPAP2A, RAMP1, SCARB1, SCN9A, SHB, SLC19A2, SLC20A2, SLC22A18, SLC30A1, SLC9A1, SLC9A3R2, SPRED2, SPRY2, SPRY4, ST3GAL5, STBD1, STOM, SYNGR2, TAPBPL, TFPI, TGM2, TM2D1, TNFSF4, TNS3	1443	plasma membrane
GO:0005773	5.238e-03	5.083	15 ARSA, DNASE2, DRAM, GAA, GNS, IDS, IDUA, LITAF, MAN2B1, MANBA, MARCH2, NEU1, NPC1, NPC2, TPP1	130	vacuole
GO:0009986	5.238e-03	5.083	15 AGRN, ARSA, BMPR2, CDH13, DPP4, FAS, FURIN, HBEGF, ICAM1, IL6ST, ITGA1, PDGFA, PLAUR, SULF1, VEGFA	130	cell surface
GO:0016020	5.397e-03	123.8	155 ACSL1, ACVR1, ADAM23, ADCY6, ADIPOR2, ADRA2A, AJAP1, ARSA, ATP13A3, ATP2A2, BBS1, BMPR2, BTN3A1, C19orf28, C4orf18, C9orf167, CADPS2, CD302, CD46, CD55, CDC42SE1, CDH13, CHPF, CLDN1, CSF1, CSGALNACT2, CYP51A1, DDX3Y, DES, DGKD, DNAJC1, DNAJC4, DOCK9, DPP4, DRAM, EDEM1, EPHA2, ERAP1, ERAP2, F10, FADS3, FAS, FURIN, GALNT3, GAP43, GEM, GNA13, GNPTAB, GPNMB, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, ICAM1, IFITM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, KCTD13, KIAA0247, KPNA4, LGALS3BP, LIMS1, LITAF, LMBRD1, LPAR1, LRIG1, LRP1, LRP5, LTBR, LYN, MAGI2, MAN1C1, MAP3K7IP2, MARCH2, MRC2, NEDD9, NEU1, NID1, NINJ1, NPC1, NR3C1, NRXN3, OLFML2A, P2RX4, PCDH7, PCYT1A, PDE4A, PDGFA, PDGFD, PIGB, PIP5K1C, PKP2, PLAUR, PLK3, PLSCR4, PMEPA1, POR, PPAP2A, PTGDS, RAMP1, RANBP2, RNF130, RTN1, SCARB1, SCN9A, SEC23IP, SEMA5A, SGPP1, SHB, SLC10A3, SLC19A2, SLC20A2, SLC22A18, SLC30A1, SLC39A8, SLC9A1, SLC9A3R2, SPRED2, SPRY2, SPRY4, SQLE, SQRDL, SREBF2, ST3GAL1, ST3GAL5, STBD1, STOM, SVEP1, SYNGR2, TAPBPL, TEX2, TFPI, TGM2, TM2D1, TM6SF1, TMEM39A, TMEM41B, TNFSF4, TNS3, TPST1, TPST2, VEGFA, VEGFB, VPS37B, WFS1, YIPF6, YRDC	3167	membrane
GO:0005887	5.911e-03	21.47	39 ACVR1, ADAM23, ADRA2A, ATP2A2, BMPR2, CD46, CD55, CLDN1, EPHA2, GPNMB, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, ICAM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, KCTD13, LPAR1, LRP1, NPC1, NRXN3, P2RX4, PCDH7, PPAP2A, RAMP1, SCN9A, SLC20A2, ST3GAL5, STBD1, STOM, SYNGR2, TM2D1, TNFSF4	549	integral to plasma membrane
GO:0031226	6.958e-03	21.66	39 ACVR1, ADAM23, ADRA2A, ATP2A2, BMPR2, CD46, CD55, CLDN1, EPHA2, GPNMB, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, ICAM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, KCTD13, LPAR1, LRP1, NPC1, NRXN3, P2RX4, PCDH7, PPAP2A, RAMP1, SCN9A, SLC20A2, ST3GAL5, STBD1, STOM, SYNGR2, TM2D1, TNFSF4	554	intrinsic to plasma membrane
GO:0016021	9.592e-03	79.06	106 ACSL1, ACVR1, ADAM23, ADCY6, ADIPOR2, ADRA2A, AJAP1, ATP13A3, ATP2A2, BMPR2, BTN3A1, C19orf28, C4orf18, C9orf167, CD302, CD46, CD55, CHPF, CLDN1, CSF1, CSGALNACT2, CYP51A1, DNAJC1, DNAJC4, DPP4, DRAM, EDEM1, EPHA2, ERAP1, ERAP2, FADS3, FAS, FURIN, GALNT3, GNPTAB, GPNMB, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, ICAM1, IFITM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, KCTD13, KIAA0247, KPNA4, LMBRD1, LPAR1, LRIG1, LRP1, LRP5, LTBR, MAN1C1, MARCH2, MRC2, NINJ1, NPC1, NRXN3, P2RX4, PCDH7, PIGB, PKP2, PLAUR, PMEPA1, PPAP2A, RAMP1, RANBP2, RNF130, RTN1, SCARB1, SCN9A, SEMA5A, SGPP1, SLC19A2, SLC20A2, SLC22A18, SLC30A1, SLC39A8, SLC9A1, SQLE, SREBF2, ST3GAL1, ST3GAL5, STBD1, STOM, SYNGR2, TAPBPL, TEX2, TM2D1, TM6SF1, TMEM39A, TMEM41B, TNFSF4, TPST1, TPST2, WFS1, YIPF6	2022	integral to membrane
GO:0031224	1.059e-02	80.2	107 ACSL1, ACVR1, ADAM23, ADCY6, ADIPOR2, ADRA2A, AJAP1, ATP13A3, ATP2A2, BMPR2, BTN3A1, C19orf28, C4orf18, C9orf167, CD302, CD46, CD55, CDH13, CHPF, CLDN1, CSF1, CSGALNACT2, CYP51A1, DNAJC1, DNAJC4, DPP4, DRAM, EDEM1, EPHA2, ERAP1, ERAP2, FADS3, FAS, FURIN, GALNT3, GNPTAB, GPNMB, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, ICAM1, IFITM1, IL1RAP, IL6, IL6ST, ITGA1, KCNN4, KCTD13, KIAA0247, KPNA4, LMBRD1, LPAR1, LRIG1, LRP1, LRP5, LTBR, MAN1C1, MARCH2, MRC2, NINJ1, NPC1, NRXN3, P2RX4, PCDH7, PIGB, PKP2, PLAUR, PMEPA1, PPAP2A, RAMP1, RANBP2, RNF130, RTN1, SCARB1, SCN9A, SEMA5A, SGPP1, SLC19A2, SLC20A2, SLC22A18, SLC30A1, SLC39A8, SLC9A1, SQLE, SREBF2, ST3GAL1, ST3GAL5, STBD1, STOM, SYNGR2, TAPBPL, TEX2, TM2D1, TM6SF1, TMEM39A, TMEM41B, TNFSF4, TPST1, TPST2, WFS1, YIPF6	2051	intrinsic to membrane
GO:0031012	2.028e-02	6.491	16 AGRN, ANGPTL4, COL15A1, COL18A1, CPZ, DCN, ECM1, FGF1, LAMA5, LGALS3BP, MFAP4, NID1, OLFML2A, SPOCK1, TNFRSF11B, VEGFA	166	extracellular matrix
GO:0005578	2.809e-02	6.1	15 AGRN, ANGPTL4, COL15A1, COL18A1, CPZ, DCN, ECM1, FGF1, LAMA5, LGALS3BP, MFAP4, NID1, SPOCK1, TNFRSF11B, VEGFA	156	proteinaceous extracellular matrix
GO:0005736	3.603e-02	0.0782	2 CD3EAP, POLR1C	2	DNA-directed RNA polymerase I complex

Id	Pvalue	ExpCount	Count	Size	Term
GO:0032393	1.086e-04	0.3492	6 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	9	MHC class I receptor activity
GO:0004871	4.237e-04	30.96	58 ACVR1, ADIPOR2, ADRA2A, AGRN, BMPR2, CCL2, CD46, ECM1, EPHA2, FAS, GNA13, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, ICAM1, IFITM1, IL1RAP, IL6ST, ITGA1, LGALS3BP, LITAF, LPAR1, LRP1, LRP5, LTBR, LYN, MAP3K2, MAP3K4, MRC2, NPC1, NR3C1, NR4A1, NR4A3, NRXN3, P2RX4, PDK2, PLAUR, PLK3, PPARD, RAMP1, RGS2, SCARB1, SEMA5A, SH3BGRL, SHB, SLC20A2, SMAD7, TM2D1, TNFRSF11B, TP53BP2, TRAF3	798	signal transducer activity
GO:0060089	4.237e-04	30.96	58 ACVR1, ADIPOR2, ADRA2A, AGRN, BMPR2, CCL2, CD46, ECM1, EPHA2, FAS, GNA13, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, HMOX1, ICAM1, IFITM1, IL1RAP, IL6ST, ITGA1, LGALS3BP, LITAF, LPAR1, LRP1, LRP5, LTBR, LYN, MAP3K2, MAP3K4, MRC2, NPC1, NR3C1, NR4A1, NR4A3, NRXN3, P2RX4, PDK2, PLAUR, PLK3, PPARD, RAMP1, RGS2, SCARB1, SEMA5A, SH3BGRL, SHB, SLC20A2, SMAD7, TM2D1, TNFRSF11B, TP53BP2, TRAF3	798	molecular transducer activity
GO:0005125	9.276e-04	2.832	13 CCL2, CSF1, GRN, IL11, IL23A, IL6, IL8, LIF, NAMPT, SCG2, TNFRSF11B, TNFSF4, VEGFA	73	cytokine activity
GO:0004872	5.563e-03	20.68	40 ACVR1, ADIPOR2, ADRA2A, BMPR2, CD46, EPHA2, FAS, GPR183, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, ICAM1, IL1RAP, IL6ST, ITGA1, LGALS3BP, LPAR1, LRP1, LRP5, LTBR, MRC2, NPC1, NR3C1, NR4A1, NR4A3, NRXN3, P2RX4, PLAUR, PPARD, RAMP1, SCARB1, SEMA5A, SLC20A2, TM2D1, TNFRSF11B	533	receptor activity
GO:0005102	6.377e-03	15.83	33 ADAM23, ANGPTL4, CCL2, CSF1, EDN1, ERAP1, FGF1, FGF7, GPNMB, GRN, HBEGF, ICAM1, IL11, IL23A, IL6, IL6ST, IL8, LAMA5, LIF, MFAP4, MTSS1, NAMPT, P2RX4, PDGFA, PDGFD, PSMB8, SCG2, SMAD7, TNFRSF11B, TNFSF4, TOB2, VEGFA, VEGFB	408	receptor binding
GO:0042803	8.188e-03	5.781	17 ACVR1, CDH13, CSF1, DGKD, DPP4, GPD1L, IL6ST, NFKB1, NR4A1, OLFML2A, P2RX4, PDGFA, SRF, TPD52, TPD52L1, VEGFA, WWTR1	149	protein homodimerization activity
GO:0008083	8.411e-03	3.647	13 CSF1, ERAP1, FGF1, FGF7, GRN, HBEGF, IL11, IL6, LIF, PDGFA, PDGFD, VEGFA, VEGFB	94	growth factor activity
GO:0015923	1.448e-02	0.5432	5 EDEM1, MAN1C1, MAN2B1, MAN2B2, MANBA	14	mannosidase activity
GO:0046983	2.113e-02	10.2	23 ACVR1, ADIPOR2, CDH13, CSF1, DGKD, DPP4, FOSB, GCLC, GPD1L, IL6ST, JUND, NFIL3, NFKB1, NR4A1, OLFML2A, P2RX4, PDGFA, POLR1C, SRF, TPD52, TPD52L1, VEGFA, WWTR1	263	protein dimerization activity
GO:0004553	2.354e-02	1.707	8 EDEM1, GAA, IDUA, MAN1C1, MAN2B1, MAN2B2, MANBA, NEU1	44	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0008484	3.248e-02	0.388	4 ARSA, GNS, IDS, SULF1	10	sulfuric ester hydrolase activity
GO:0019838	4.639e-02	2.444	9 A2M, ACVR1, ESM1, FURIN, IGFBP5, IGFBP7, IL1RAP, IL6ST, PDGFA	63	growth factor binding

Id	Pvalue	ExpCount	Count	Size	Term
04610	5.561e-04	1.696	10 A2M, C1R, C1S, CD46, CD55, CFH, F10, PLAUR, PROS1, TFPI	34	Complement and coagulation cascades
05332	6.134e-04	1.048	8 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G, IL6	21	Graft-versus-host disease
04060	2.628e-03	6.087	18 ACVR1, BMPR2, CCL2, CSF1, FAS, IL11, IL1RAP, IL23A, IL6, IL6ST, IL8, LIF, LTBR, PDGFA, TNFRSF11B, TNFSF4, VEGFA, VEGFB	122	Cytokine-cytokine receptor interaction
05330	4.711e-03	1.048	7 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	21	Allograft rejection
05320	6.278e-03	1.098	7 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	22	Autoimmune thyroid disease
01032	8.104e-03	1.147	7 GNS, IDS, IDUA, MAN2B1, MAN2B2, MANBA, NEU1	23	Glycan structures - degradation
04940	1.613e-02	1.297	7 FAS, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G	26	Type I diabetes mellitus

No enriched terms

No enriched terms

Entrez genes

A2Malpha-2-macroglobulin (217757_at), score: -0.3 ABHD4abhydrolase domain containing 4 (218581_at), score: -0.35 ABLIM3actin binding LIM protein family, member 3 (205730_s_at), score: -0.36 ACSL1acyl-CoA synthetase long-chain family member 1 (201963_at), score: -0.27 ACVR1activin A receptor, type I (203935_at), score: -0.29 ADAM23ADAM metallopeptidase domain 23 (206046_at), score: -0.32 ADCY6adenylate cyclase 6 (209195_s_at), score: -0.31 ADIPOR2adiponectin receptor 2 (201346_at), score: -0.31 ADRA2Aadrenergic, alpha-2A-, receptor (209869_at), score: -0.39 AGRNagrin (217419_x_at), score: -0.33 AJAP1adherens junctions associated protein 1 (206460_at), score: -0.3 AKIRIN1akirin 1 (217893_s_at), score: -0.27 ANGPTL4angiopoietin-like 4 (221009_s_at), score: -0.58 ANK2ankyrin 2, neuronal (202920_at), score: -0.35 ARID5AAT rich interactive domain 5A (MRF1-like) (213138_at), score: -0.46 ARL4CADP-ribosylation factor-like 4C (202207_at), score: -0.27 ARMC9armadillo repeat containing 9 (219637_at), score: -0.27 ARSAarylsulfatase A (204443_at), score: -0.3 ATP13A3ATPase type 13A3 (219558_at), score: -0.29 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (212361_s_at), score: -0.27 BBS1Bardet-Biedl syndrome 1 (218471_s_at), score: -0.34 BCL7AB-cell CLL/lymphoma 7A (203795_s_at), score: -0.4 BHLHE40basic helix-loop-helix family, member e40 (201170_s_at), score: -0.31 BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase) (210214_s_at), score: -0.41 BTN3A1butyrophilin, subfamily 3, member A1 (209770_at), score: -0.33 C14orf159chromosome 14 open reading frame 159 (218298_s_at), score: -0.3 C17orf71chromosome 17 open reading frame 71 (218514_at), score: -0.31 C17orf91chromosome 17 open reading frame 91 (214696_at), score: -0.29 C19orf28chromosome 19 open reading frame 28 (220178_at), score: -0.46 C1Rcomplement component 1, r subcomponent (212067_s_at), score: -0.52 C1RLcomplement component 1, r subcomponent-like (218983_at), score: -0.29 C1Scomplement component 1, s subcomponent (208747_s_at), score: -0.43 C4orf18chromosome 4 open reading frame 18 (219872_at), score: -0.36 C9orf167chromosome 9 open reading frame 167 (219620_x_at), score: -0.47 CADPS2Ca++-dependent secretion activator 2 (219572_at), score: -0.42 CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (211368_s_at), score: -0.31 CASP4caspase 4, apoptosis-related cysteine peptidase (209310_s_at), score: -0.43 CBFBcore-binding factor, beta subunit (206788_s_at), score: -0.35 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: -0.5 CD302CD302 molecule (203799_at), score: -0.33 CD3EAPCD3e molecule, epsilon associated protein (205264_at), score: -0.27 CD46CD46 molecule, complement regulatory protein (211574_s_at), score: -0.28 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: -0.35 CDC42SE1CDC42 small effector 1 (218157_x_at), score: -0.4 CDH13cadherin 13, H-cadherin (heart) (204726_at), score: -0.31 CFHcomplement factor H (213800_at), score: -0.32 CFHR1complement factor H-related 1 (215388_s_at), score: -0.34 CHPFchondroitin polymerizing factor (202175_at), score: -0.31 CLDN1claudin 1 (218182_s_at), score: -0.27 CLIP3CAP-GLY domain containing linker protein 3 (212358_at), score: -0.38 CLUclusterin (208791_at), score: -0.34 COL15A1collagen, type XV, alpha 1 (203477_at), score: -0.74 COL18A1collagen, type XVIII, alpha 1 (209081_s_at), score: -0.28 CPZcarboxypeptidase Z (211062_s_at), score: -0.44 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: -0.57 CSF1colony stimulating factor 1 (macrophage) (209716_at), score: -0.27 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: -0.32 CSRNP2cysteine-serine-rich nuclear protein 2 (221260_s_at), score: -0.29 CST3cystatin C (201360_at), score: -0.5 CTSOcathepsin O (203758_at), score: -0.31 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: -0.38 DAAM2dishevelled associated activator of morphogenesis 2 (212793_at), score: -0.3 DCNdecorin (211896_s_at), score: -0.34 DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked (205000_at), score: -0.48 DESdesmin (202222_s_at), score: 1 DGKDdiacylglycerol kinase, delta 130kDa (208072_s_at), score: -0.53 DNAJB9DnaJ (Hsp40) homolog, subfamily B, member 9 (202843_at), score: -0.28 DNAJC1DnaJ (Hsp40) homolog, subfamily C, member 1 (218409_s_at), score: -0.27 DNAJC4DnaJ (Hsp40) homolog, subfamily C, member 4 (206782_s_at), score: -0.27 DNASE2deoxyribonuclease II, lysosomal (214992_s_at), score: -0.43 DOCK9dedicator of cytokinesis 9 (212538_at), score: -0.4 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: -0.48 DRAMdamage-regulated autophagy modulator (218627_at), score: -0.34 DUSP3dual specificity phosphatase 3 (201537_s_at), score: -0.35 ECM1extracellular matrix protein 1 (209365_s_at), score: -0.38 EDEM1ER degradation enhancer, mannosidase alpha-like 1 (203279_at), score: -0.29 EDN1endothelin 1 (218995_s_at), score: -0.27 EFHD1EF-hand domain family, member D1 (209343_at), score: -0.35 EGR3early growth response 3 (206115_at), score: -0.44 EIF1AYeukaryotic translation initiation factor 1A, Y-linked (204409_s_at), score: -0.39 EPHA2EPH receptor A2 (203499_at), score: -0.36 ERAP1endoplasmic reticulum aminopeptidase 1 (214012_at), score: -0.46 ERAP2endoplasmic reticulum aminopeptidase 2 (219759_at), score: -0.33 ESM1endothelial cell-specific molecule 1 (208394_x_at), score: -0.32 F10coagulation factor X (205620_at), score: -0.4 FADS3fatty acid desaturase 3 (216080_s_at), score: -0.35 FAM102Afamily with sequence similarity 102, member A (212400_at), score: -0.27 FASFas (TNF receptor superfamily, member 6) (216252_x_at), score: -0.27 FGF1fibroblast growth factor 1 (acidic) (205117_at), score: -0.28 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: -0.41 FHOD1formin homology 2 domain containing 1 (218530_at), score: -0.49 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: -0.5 FURINfurin (paired basic amino acid cleaving enzyme) (201945_at), score: -0.35 GAAglucosidase, alpha; acid (202812_at), score: -0.33 GALNT3UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) (203397_s_at), score: -0.41 GAP43growth associated protein 43 (204471_at), score: 0.89 GCLCglutamate-cysteine ligase, catalytic subunit (202923_s_at), score: -0.29 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: -0.49 GNA13guanine nucleotide binding protein (G protein), alpha 13 (206917_at), score: -0.29 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: -0.42 GNSglucosamine (N-acetyl)-6-sulfatase (203676_at), score: -0.31 GPD1Lglycerol-3-phosphate dehydrogenase 1-like (212510_at), score: -0.32 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: -0.64 GPR183G protein-coupled receptor 183 (205419_at), score: -0.36 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: -0.38 GPX3glutathione peroxidase 3 (plasma) (214091_s_at), score: -0.38 GRAMD3GRAM domain containing 3 (218706_s_at), score: -0.35 GRNgranulin (211284_s_at), score: -0.44 GSTM1glutathione S-transferase mu 1 (204550_x_at), score: -0.36 GSTT1glutathione S-transferase theta 1 (203815_at), score: -0.33 H2BFSH2B histone family, member S (208579_x_at), score: -0.33 HBEGFheparin-binding EGF-like growth factor (203821_at), score: -0.56 HHEXhematopoietically expressed homeobox (215933_s_at), score: -0.52 HIPK3homeodomain interacting protein kinase 3 (210148_at), score: -0.35 HIST1H2AChistone cluster 1, H2ac (215071_s_at), score: -0.43 HIST1H2BKhistone cluster 1, H2bk (209806_at), score: -0.36 HIVEP1human immunodeficiency virus type I enhancer binding protein 1 (204512_at), score: -0.34 HLA-Amajor histocompatibility complex, class I, A (217436_x_at), score: -0.5 HLA-Bmajor histocompatibility complex, class I, B (211911_x_at), score: -0.43 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: -0.63 HLA-Emajor histocompatibility complex, class I, E (200904_at), score: -0.63 HLA-Fmajor histocompatibility complex, class I, F (204806_x_at), score: -0.59 HLA-Gmajor histocompatibility complex, class I, G (211530_x_at), score: -0.29 HMOX1heme oxygenase (decycling) 1 (203665_at), score: -0.37 HOXB6homeobox B6 (205366_s_at), score: -0.29 HOXB7homeobox B7 (204779_s_at), score: -0.31 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: -0.43 IDSiduronate 2-sulfatase (202439_s_at), score: -0.29 IDUAiduronidase, alpha-L- (205059_s_at), score: -0.41 IFITM1interferon induced transmembrane protein 1 (9-27) (214022_s_at), score: -0.29 IGFBP5insulin-like growth factor binding protein 5 (203424_s_at), score: -0.35 IGFBP7insulin-like growth factor binding protein 7 (201162_at), score: -0.38 IL11interleukin 11 (206924_at), score: -0.4 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: -0.52 IL23Ainterleukin 23, alpha subunit p19 (211796_s_at), score: -0.45 IL6interleukin 6 (interferon, beta 2) (205207_at), score: -0.61 IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor) (204864_s_at), score: -0.41 IL8interleukin 8 (202859_x_at), score: -0.36 ITGA1integrin, alpha 1 (214660_at), score: -0.35 JARID1Djumonji, AT rich interactive domain 1D (206700_s_at), score: -0.38 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: -0.31 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: -0.41 JUNDjun D proto-oncogene (203751_x_at), score: -0.43 KCNN4potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (204401_at), score: -0.29 KCTD13potassium channel tetramerisation domain containing 13 (45653_at), score: -0.27 KHDRBS3KH domain containing, RNA binding, signal transduction associated 3 (209781_s_at), score: -0.32 KIAA0247KIAA0247 (202181_at), score: -0.4 KLHL21kelch-like 21 (Drosophila) (203068_at), score: -0.4 KLHL26kelch-like 26 (Drosophila) (219354_at), score: -0.36 KPNA4karyopherin alpha 4 (importin alpha 3) (209653_at), score: -0.28 LAMA5laminin, alpha 5 (210150_s_at), score: -0.28 LEPREL1leprecan-like 1 (218717_s_at), score: -0.31 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: -0.4 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: -0.52 LIMS1LIM and senescent cell antigen-like domains 1 (207198_s_at), score: -0.3 LITAFlipopolysaccharide-induced TNF factor (200706_s_at), score: -0.43 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: -0.39 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: -0.48 LMOD1leiomodin 1 (smooth muscle) (203766_s_at), score: -0.27 LOC100128809similar to hCG2045829 (215707_s_at), score: -0.39 LPAR1lysophosphatidic acid receptor 1 (204038_s_at), score: -0.27 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: -0.33 LRP1low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) (200784_s_at), score: -0.27 LRP5low density lipoprotein receptor-related protein 5 (209468_at), score: -0.27 LTBRlymphotoxin beta receptor (TNFR superfamily, member 3) (203005_at), score: -0.36 LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog (202625_at), score: -0.37 MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) (209348_s_at), score: -0.36 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: -0.32 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: -0.46 MAN2B1mannosidase, alpha, class 2B, member 1 (209166_s_at), score: -0.36 MAN2B2mannosidase, alpha, class 2B, member 2 (214703_s_at), score: -0.29 MANBAmannosidase, beta A, lysosomal (203778_at), score: -0.4 MAP1Smicrotubule-associated protein 1S (218522_s_at), score: -0.4 MAP3K2mitogen-activated protein kinase kinase kinase 2 (221695_s_at), score: -0.28 MAP3K4mitogen-activated protein kinase kinase kinase 4 (216199_s_at), score: -0.31 MAP3K7IP2mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (210284_s_at), score: -0.32 MARCH2membrane-associated ring finger (C3HC4) 2 (210075_at), score: -0.29 MEIS1Meis homeobox 1 (204069_at), score: -0.39 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: -0.51 MFAP4microfibrillar-associated protein 4 (212713_at), score: -0.45 MRC2mannose receptor, C type 2 (37408_at), score: -0.27 MTSS1metastasis suppressor 1 (203037_s_at), score: -0.5 NAB1NGFI-A binding protein 1 (EGR1 binding protein 1) (208047_s_at), score: -0.36 NACAP1nascent-polypeptide-associated complex alpha polypeptide pseudogene 1 (211445_x_at), score: 0.89 NADSYN1NAD synthetase 1 (218840_s_at), score: -0.27 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: -0.37 NEDD9neural precursor cell expressed, developmentally down-regulated 9 (202149_at), score: -0.28 NEU1sialidase 1 (lysosomal sialidase) (208926_at), score: -0.27 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: -0.51 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: -0.36 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: -0.56 NID1nidogen 1 (202008_s_at), score: -0.5 NINJ1ninjurin 1 (203045_at), score: -0.54 NPnucleoside phosphorylase (201695_s_at), score: -0.3 NPC1Niemann-Pick disease, type C1 (202679_at), score: -0.29 NPC2Niemann-Pick disease, type C2 (200701_at), score: -0.41 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: -0.27 NR4A1nuclear receptor subfamily 4, group A, member 1 (202340_x_at), score: -0.28 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: -0.44 NRXN3neurexin 3 (205795_at), score: -0.37 OLFML2Aolfactomedin-like 2A (213075_at), score: -0.39 OS9osteosarcoma amplified 9, endoplasmic reticulum associated protein (200714_x_at), score: -0.44 P2RX4purinergic receptor P2X, ligand-gated ion channel, 4 (204088_at), score: -0.36 PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (203557_s_at), score: -0.35 PCDH7protocadherin 7 (205534_at), score: -0.39 PCDHG@protocadherin gamma cluster (215836_s_at), score: -0.36 PCYT1Aphosphate cytidylyltransferase 1, choline, alpha (204210_s_at), score: -0.26 PDE4Aphosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) (204735_at), score: -0.27 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: -0.53 PDGFDplatelet derived growth factor D (219304_s_at), score: -0.37 PDK2pyruvate dehydrogenase kinase, isozyme 2 (202590_s_at), score: -0.27 PDLIM3PDZ and LIM domain 3 (209621_s_at), score: -0.47 PHLDA3pleckstrin homology-like domain, family A, member 3 (218634_at), score: -0.28 PIGBphosphatidylinositol glycan anchor biosynthesis, class B (214151_s_at), score: -0.38 PIP5K1Cphosphatidylinositol-4-phosphate 5-kinase, type I, gamma (212518_at), score: -0.3 PKP2plakophilin 2 (207717_s_at), score: -0.57 PLAURplasminogen activator, urokinase receptor (211924_s_at), score: -0.33 PLK3polo-like kinase 3 (Drosophila) (204958_at), score: -0.32 PLSCR4phospholipid scramblase 4 (218901_at), score: -0.3 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: -0.6 PMS2L3postmeiotic segregation increased 2-like 3 (214473_x_at), score: -0.28 POLR1Cpolymerase (RNA) I polypeptide C, 30kDa (207515_s_at), score: -0.33 PORP450 (cytochrome) oxidoreductase (208928_at), score: -0.28 PPAP2Aphosphatidic acid phosphatase type 2A (209147_s_at), score: -0.3 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: -0.39 PROS1protein S (alpha) (207808_s_at), score: -0.33 PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (209040_s_at), score: -0.27 PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) (204279_at), score: -0.32 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: -0.55 PTPN12protein tyrosine phosphatase, non-receptor type 12 (216915_s_at), score: -0.29 RAMP1receptor (G protein-coupled) activity modifying protein 1 (204916_at), score: -0.36 RANBP2RAN binding protein 2 (201711_x_at), score: -0.32 RARRES3retinoic acid receptor responder (tazarotene induced) 3 (204070_at), score: -0.28 RCAN2regulator of calcineurin 2 (203498_at), score: -0.27 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: -0.37 RGPD5RANBP2-like and GRIP domain containing 5 (210676_x_at), score: -0.28 RGS2regulator of G-protein signaling 2, 24kDa (202388_at), score: -0.52 RNASET2ribonuclease T2 (217983_s_at), score: -0.29 RNF130ring finger protein 130 (217865_at), score: -0.33 RNF24ring finger protein 24 (204669_s_at), score: -0.3 RPS28P6ribosomal protein S28 pseudogene 6 (216380_x_at), score: -0.37 RPS4Y1ribosomal protein S4, Y-linked 1 (201909_at), score: -0.57 RRADRas-related associated with diabetes (204803_s_at), score: -0.62 RTN1reticulon 1 (203485_at), score: -0.33 RUNX1runt-related transcription factor 1 (209360_s_at), score: -0.47 SAT1spermidine/spermine N1-acetyltransferase 1 (213988_s_at), score: -0.36 SCARB1scavenger receptor class B, member 1 (201819_at), score: -0.48 SCG2secretogranin II (chromogranin C) (204035_at), score: -0.48 SCN9Asodium channel, voltage-gated, type IX, alpha subunit (206950_at), score: -0.29 SEC23IPSEC23 interacting protein (216392_s_at), score: -0.27 SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (205405_at), score: -0.27 SENP5SUMO1/sentrin specific peptidase 5 (213184_at), score: -0.38 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: -0.43 SERPINB8serpin peptidase inhibitor, clade B (ovalbumin), member 8 (206034_at), score: -0.29 SETXsenataxin (201964_at), score: -0.4 SFRP1secreted frizzled-related protein 1 (202036_s_at), score: -0.36 SFRS2Bsplicing factor, arginine/serine-rich 2B (213152_s_at), score: -0.33 SGPP1sphingosine-1-phosphate phosphatase 1 (221268_s_at), score: -0.27 SH3BGRLSH3 domain binding glutamic acid-rich protein like (201311_s_at), score: -0.36 SHBSrc homology 2 domain containing adaptor protein B (204657_s_at), score: -0.35 SIN3BSIN3 homolog B, transcription regulator (yeast) (209352_s_at), score: -0.28 SLC10A3solute carrier family 10 (sodium/bile acid cotransporter family), member 3 (204928_s_at), score: -0.34 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: -0.42 SLC20A2solute carrier family 20 (phosphate transporter), member 2 (202744_at), score: -0.32 SLC22A18solute carrier family 22, member 18 (204981_at), score: -0.32 SLC30A1solute carrier family 30 (zinc transporter), member 1 (212907_at), score: -0.28 SLC39A8solute carrier family 39 (zinc transporter), member 8 (209267_s_at), score: -0.28 SLC9A1solute carrier family 9 (sodium/hydrogen exchanger), member 1 (209453_at), score: -0.3 SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (209830_s_at), score: -0.29 SMAD7SMAD family member 7 (204790_at), score: -0.28 SMOXspermine oxidase (210357_s_at), score: -0.43 SMURF1SMAD specific E3 ubiquitin protein ligase 1 (212666_at), score: -0.3 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: -0.44 SOX9SRY (sex determining region Y)-box 9 (202935_s_at), score: -0.27 SPATA20spermatogenesis associated 20 (218164_at), score: -0.35 SPHK1sphingosine kinase 1 (219257_s_at), score: -0.29 SPOCK1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 (202363_at), score: -0.28 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: -0.48 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: -0.46 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: -0.52 SQLEsqualene epoxidase (213562_s_at), score: -0.37 SQRDLsulfide quinone reductase-like (yeast) (217995_at), score: -0.3 SREBF2sterol regulatory element binding transcription factor 2 (201247_at), score: -0.27 SRFserum response factor (c-fos serum response element-binding transcription factor) (202401_s_at), score: -0.39 ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (208322_s_at), score: -0.34 ST3GAL5ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (203217_s_at), score: -0.31 STBD1starch binding domain 1 (203986_at), score: -0.35 STK38Lserine/threonine kinase 38 like (212572_at), score: -0.44 STOMstomatin (201060_x_at), score: -0.37 SULF1sulfatase 1 (212353_at), score: -0.36 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: -0.43 SYNGR2synaptogyrin 2 (201079_at), score: -0.31 TAPBPLTAP binding protein-like (218746_at), score: -0.27 TBX3T-box 3 (219682_s_at), score: -0.32 TCTN1tectonic family member 1 (218584_at), score: -0.35 TEX2testis expressed 2 (218099_at), score: -0.47 TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) (209676_at), score: -0.32 TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) (201042_at), score: -0.43 TM2D1TM2 domain containing 1 (211703_s_at), score: -0.4 TM6SF1transmembrane 6 superfamily member 1 (219892_at), score: -0.52 TMEM39Atransmembrane protein 39A (218615_s_at), score: -0.42 TMEM41Btransmembrane protein 41B (212623_at), score: -0.55 TNFAIP2tumor necrosis factor, alpha-induced protein 2 (202510_s_at), score: -0.49 TNFRSF11Btumor necrosis factor receptor superfamily, member 11b (204933_s_at), score: -0.35 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: -0.53 TNS3tensin 3 (217853_at), score: -0.37 TOB2transducer of ERBB2, 2 (221496_s_at), score: -0.3 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: -0.35 TP53I11tumor protein p53 inducible protein 11 (214667_s_at), score: -0.5 TPD52tumor protein D52 (201690_s_at), score: -0.45 TPD52L1tumor protein D52-like 1 (203786_s_at), score: -0.29 TPP1tripeptidyl peptidase I (200742_s_at), score: -0.69 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: -0.4 TPST2tyrosylprotein sulfotransferase 2 (204079_at), score: -0.29 TRAF3TNF receptor-associated factor 3 (221571_at), score: -0.35 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: -0.6 TRIB2tribbles homolog 2 (Drosophila) (202478_at), score: -0.29 TRIM22tripartite motif-containing 22 (213293_s_at), score: -0.37 TRIM32tripartite motif-containing 32 (203846_at), score: -0.28 TTPALtocopherol (alpha) transfer protein-like (219633_at), score: -0.31 UBA7ubiquitin-like modifier activating enzyme 7 (203281_s_at), score: -0.32 UBE3Bubiquitin protein ligase E3B (212403_at), score: -0.38 UPP1uridine phosphorylase 1 (203234_at), score: -0.29 UTP3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) (209486_at), score: -0.29 VEGFAvascular endothelial growth factor A (211527_x_at), score: -0.47 VEGFBvascular endothelial growth factor B (203683_s_at), score: -0.4 VPS37Bvacuolar protein sorting 37 homolog B (S. cerevisiae) (221704_s_at), score: -0.3 WDR3WD repeat domain 3 (218882_s_at), score: -0.26 WFS1Wolfram syndrome 1 (wolframin) (202908_at), score: -0.3 WT1Wilms tumor 1 (206067_s_at), score: -0.38 WWTR1WW domain containing transcription regulator 1 (202132_at), score: -0.4 YIPF6Yip1 domain family, member 6 (212341_at), score: -0.31 YRDCyrdC domain containing (E. coli) (218647_s_at), score: -0.45 ZKSCAN3zinc finger with KRAB and SCAN domains 3 (211773_s_at), score: 0.87 ZNF263zinc finger protein 263 (203707_at), score: -0.27 ZNF282zinc finger protein 282 (212892_at), score: -0.39 ZNF35zinc finger protein 35 (206096_at), score: -0.5 ZNF672zinc finger protein 672 (218068_s_at), score: -0.35

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
46A.CEL	1	3	DS-mosaic	hgu133plus2	none	DS-mosaic 1
E-GEOD-3407-raw-cel-1437949557.cel	1	4	Cockayne	hgu133a	CS	eGFP
2Twin.CEL	2	2	DS-twin	hgu133plus2	none	DS-twin 2
5CTwin.CEL	5	2	DS-twin	hgu133plus2	Down	DS-twin 5
6Twin.CEL	6	2	DS-twin	hgu133plus2	none	DS-twin 6
1Twin.CEL	1	2	DS-twin	hgu133plus2	Down	DS-twin 1