Under-expression is coded with green,
over-expression with red color.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
cell killing
Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.
leukocyte mediated cytotoxicity
The directed killing of a target cell by a leukocyte.
regulation of leukocyte mediated cytotoxicity
Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
negative regulation of leukocyte mediated cytotoxicity
Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
T cell mediated cytotoxicity
The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
regulation of T cell mediated cytotoxicity
Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.
negative regulation of T cell mediated cytotoxicity
Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
regulation of protein amino acid phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
negative regulation of protein amino acid phosphorylation
Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein.
adaptive immune response
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).
immune effector process
Any process of the immune system that occurs as part of an immune response.
activation of immune response
Any process that initiates an immune response.
immune system process
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
leukocyte mediated immunity
Any process involved in the carrying out of an immune response by a leukocyte.
lymphocyte mediated immunity
Any process involved in the carrying out of an immune response by a lymphocyte.
humoral immune response mediated by circulating immunoglobulin
An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
T cell mediated immunity
Any process involved in the carrying out of an immune response by a T cell.
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.
acute inflammatory response
Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.
activation of plasma proteins involved in acute inflammatory response
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
regulation of immune system process
Any process that modulates the frequency, rate, or extent of an immune system process.
negative regulation of immune system process
Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
regulation of immune effector process
Any process that modulates the frequency, rate, or extent of an immune effector process.
negative regulation of immune effector process
Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
regulation of leukocyte mediated immunity
Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.
negative regulation of leukocyte mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
regulation of lymphocyte mediated immunity
Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.
negative regulation of lymphocyte mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
regulation of T cell mediated immunity
Any process that modulates the frequency, rate, or extent of T cell mediated immunity.
negative regulation of T cell mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
regulation of adaptive immune response
Any process that modulates the frequency, rate, or extent of an adaptive immune response.
negative regulation of adaptive immune response
Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
defense response
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
blood coagulation
The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
apoptosis
A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
protein modification process
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
protein amino acid phosphorylation
The process of introducing a phosphate group on to a protein.
protein maturation by peptide bond cleavage
The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.
lipid metabolic process
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
cellular aromatic compound metabolic process
The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.
phosphorus metabolic process
The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4).
phosphate metabolic process
The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.
induction of apoptosis
A process that directly activates any of the steps required for cell death by apoptosis.
response to stress
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
immune response
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
complement activation, alternative pathway
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
complement activation, classical pathway
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
humoral immune response
An immune response mediated through a body fluid.
cellular defense response
A defense response that is mediated by cells.
hemostasis
The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
steroid metabolic process
The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
bile acid metabolic process
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
cell death
A biological process that results in permanent cessation of all vital functions of a cell.
programmed cell death
Cell death resulting from activation of endogenous cellular processes.
cytolysis
The rupture of cell membranes and the loss of cytoplasm.
catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
negative regulation of metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
gene expression
The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
negative regulation of phosphorus metabolic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
negative regulation of macromolecule metabolic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of cell death
Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
positive regulation of cell death
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
induction of programmed cell death
A process which directly activates any of the steps required for programmed cell death.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
immunoglobulin mediated immune response
An immune response mediated by immunoglobulins, whether cell-bound or in solution.
death
A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.
phosphorylation
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
regulation of apoptosis
Any process that modulates the occurrence or rate of cell death by apoptosis.
protein processing
Any protein maturation process achieved by the cleavage of peptide bonds.
regulation of phosphate metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
aromatic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
B cell mediated immunity
Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
carboxylic acid metabolic process
The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
negative regulation of cellular metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cell killing
Any process that modulates the frequency, rate or extent of cell killing, the process by which a cell brings about the death of another cell, either in the same or a different organism.
negative regulation of cell killing
Any process that stops, prevents or reduces the frequency, rate or extent of cell killing.
regulation of protein modification process
Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
negative regulation of protein modification process
Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
regulation of protein amino acid autophosphorylation
Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.
negative regulation of protein amino acid autophosphorylation
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
regulation of cellular protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
negative regulation of cellular protein metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
monocarboxylic acid metabolic process
The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
wound healing
The series of events that restore integrity to a damaged tissue, following an injury.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
regulation of phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
negative regulation of phosphorylation
Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.
positive regulation of apoptosis
Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.
regulation of programmed cell death
Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
positive regulation of programmed cell death
Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
macromolecule modification
The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
post-translational protein modification
The covalent alteration of one or more amino acids occurring in a protein after the protein has been completely translated and released from the ribosome.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
cellular protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.
small molecule metabolic process
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
innate immune response
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
negative regulation of phosphate metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
protein amino acid autophosphorylation
The phosphorylation by a protein of one or more of its own amino acid residues, or residues on an identical protein.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of biological process
Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of cellular process
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
negative regulation of response to stimulus
Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
negative regulation of immune response
Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
coagulation
The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.
regulation of body fluid levels
Any process that modulates the levels of body fluids.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of phosphorus metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
regulation of protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
negative regulation of protein metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.
protein maturation
Any process leading to the attainment of the full functional capacity of a protein.
regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
all
NA
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
cell death
A biological process that results in permanent cessation of all vital functions of a cell.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of immune system process
Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
negative regulation of metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
negative regulation of cell killing
Any process that stops, prevents or reduces the frequency, rate or extent of cell killing.
negative regulation of cellular process
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of immune system process
Any process that modulates the frequency, rate, or extent of an immune system process.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
regulation of cell killing
Any process that modulates the frequency, rate or extent of cell killing, the process by which a cell brings about the death of another cell, either in the same or a different organism.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of biological process
Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
immune response
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
regulation of response to stimulus
Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
negative regulation of response to stimulus
Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
negative regulation of macromolecule metabolic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of macromolecule metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
negative regulation of cellular metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
cellular catabolic process
The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.
cellular macromolecule metabolic process
The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.
protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
organic acid metabolic process
The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
cellular ketone metabolic process
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
small molecule catabolic process
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
regulation of leukocyte mediated cytotoxicity
Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
negative regulation of cell killing
Any process that stops, prevents or reduces the frequency, rate or extent of cell killing.
negative regulation of leukocyte mediated cytotoxicity
Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
leukocyte mediated cytotoxicity
The directed killing of a target cell by a leukocyte.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
negative regulation of immune system process
Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.
positive regulation of immune system process
Any process that activates or increases the frequency, rate, or extent of an immune system process.
negative regulation of immune effector process
Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
immune effector process
Any process of the immune system that occurs as part of an immune response.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
negative regulation of immune response
Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of cell death
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
negative regulation of cellular metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cell death
Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of cellular process
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
negative regulation of immune response
Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of response to stimulus
Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
negative regulation of response to stimulus
Any process that stops, prevents or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
regulation of immune response
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
regulation of body fluid levels
Any process that modulates the levels of body fluids.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
negative regulation of cellular metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
negative regulation of macromolecule metabolic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
regulation of protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
regulation of protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
negative regulation of protein metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.
protein maturation
Any process leading to the attainment of the full functional capacity of a protein.
cellular protein metabolic process
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes protein modification.
organic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
aromatic compound catabolic process
The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.
negative regulation of phosphorus metabolic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
regulation of phosphorus metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
oxoacid metabolic process
The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
negative regulation of leukocyte mediated cytotoxicity
Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
regulation of T cell mediated cytotoxicity
Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.
negative regulation of T cell mediated cytotoxicity
Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
regulation of leukocyte mediated cytotoxicity
Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.
negative regulation of immune effector process
Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.
regulation of leukocyte mediated immunity
Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.
negative regulation of leukocyte mediated cytotoxicity
Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.
negative regulation of leukocyte mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
regulation of immune effector process
Any process that modulates the frequency, rate, or extent of an immune effector process.
negative regulation of immune response
Any process that stops, prevents or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
positive regulation of immune response
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
activation of immune response
Any process that initiates an immune response.
regulation of adaptive immune response
Any process that modulates the frequency, rate, or extent of an adaptive immune response.
negative regulation of adaptive immune response
Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
complement activation, alternative pathway
Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
positive regulation of cell death
Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
regulation of programmed cell death
Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
positive regulation of programmed cell death
Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
blood coagulation
The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
innate immune response
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
inflammatory response
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
negative regulation of cellular protein metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
negative regulation of cellular protein metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
negative regulation of phosphorus metabolic process
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
regulation of cellular protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
negative regulation of protein metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.
protein modification process
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
regulation of cellular protein metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
negative regulation of cellular protein metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
regulation of protein modification process
Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
negative regulation of protein modification process
Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
regulation of phosphate metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
negative regulation of phosphate metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
negative regulation of T cell mediated cytotoxicity
Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
negative regulation of leukocyte mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.
regulation of lymphocyte mediated immunity
Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.
negative regulation of lymphocyte mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
negative regulation of adaptive immune response
Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.
T cell mediated immunity
Any process involved in the carrying out of an immune response by a T cell.
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
B cell mediated immunity
Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.
complement activation, classical pathway
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
regulation of apoptosis
Any process that modulates the occurrence or rate of cell death by apoptosis.
positive regulation of programmed cell death
Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.
positive regulation of apoptosis
Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.
blood coagulation
The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
negative regulation of protein modification process
Any process that stops, prevents or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.
negative regulation of phosphate metabolic process
Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving phosphates.
carboxylic acid catabolic process
The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
protein amino acid phosphorylation
The process of introducing a phosphate group on to a protein.
regulation of phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
negative regulation of phosphorylation
Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.
T cell mediated cytotoxicity
The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
negative regulation of lymphocyte mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.
regulation of T cell mediated immunity
Any process that modulates the frequency, rate, or extent of T cell mediated immunity.
negative regulation of T cell mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
regulation of T cell mediated immunity
Any process that modulates the frequency, rate, or extent of T cell mediated immunity.
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.
negative regulation of T cell mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
positive regulation of apoptosis
Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.
induction of apoptosis
A process that directly activates any of the steps required for cell death by apoptosis.
negative regulation of protein amino acid phosphorylation
Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein.
negative regulation of protein amino acid phosphorylation
Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein.
regulation of protein amino acid phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
negative regulation of phosphorylation
Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.
activation of plasma proteins involved in acute inflammatory response
Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.
regulation of protein amino acid phosphorylation
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
negative regulation of protein amino acid phosphorylation
Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein.
bile acid metabolic process
The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
regulation of T cell mediated cytotoxicity
Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.
negative regulation of T cell mediated immunity
Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.
negative regulation of T cell mediated cytotoxicity
Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
humoral immune response mediated by circulating immunoglobulin
An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
T cell mediated cytotoxicity
The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
complement activation
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
negative regulation of protein amino acid autophosphorylation
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
regulation of protein amino acid autophosphorylation
Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.
negative regulation of protein amino acid autophosphorylation
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
membrane attack complex
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
extracellular space
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
stored secretory granule
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
external side of plasma membrane
The side of the plasma membrane that is opposite to the side that faces the cytoplasm.
cell surface
The external part of the cell wall and/or plasma membrane.
pore complex
Any small opening in a membrane that allows the passage of gases and/or liquids.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
platelet alpha granule
A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).
platelet alpha granule lumen
The volume enclosed by the membrane of the platelet alpha granule.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
membrane-enclosed lumen
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.
vesicle
Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
vesicle lumen
The volume enclosed by the membrane or protein that forms a vesicle.
membrane-bounded vesicle
Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
cytoplasmic membrane-bounded vesicle lumen
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
all
NA
extracellular region part
Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
organelle lumen
The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
vesicle lumen
The volume enclosed by the membrane or protein that forms a vesicle.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
cytoplasmic membrane-bounded vesicle lumen
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
membrane attack complex
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
external side of plasma membrane
The side of the plasma membrane that is opposite to the side that faces the cytoplasm.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
cytoplasmic membrane-bounded vesicle lumen
The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.
pore complex
Any small opening in a membrane that allows the passage of gases and/or liquids.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
membrane attack complex
A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.
platelet alpha granule lumen
The volume enclosed by the membrane of the platelet alpha granule.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
metal ion transmembrane transporter activity
Catalysis of the transfer of metal ions from one side of a membrane to the other.
aryldialkylphosphatase activity
Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.
enzyme inhibitor activity
Stops, prevents or reduces the activity of an enzyme.
endopeptidase inhibitor activity
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
serine-type endopeptidase inhibitor activity
Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.
carbohydrate binding
Interacting selectively and non-covalently with any carbohydrate, any of a group of organic compounds based of the general formula Cx(H2O)y.
transporter activity
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
transmembrane transporter activity
Enables the transfer of a substance from one side of a membrane to the other.
secondary active transmembrane transporter activity
Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
lipid binding
Interacting selectively and non-covalently with a lipid.
cation transmembrane transporter activity
Catalysis of the transfer of cation from one side of the membrane to the other.
endopeptidase regulator activity
Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
ion transmembrane transporter activity
Catalysis of the transfer of an ion from one side of a membrane to the other.
monovalent inorganic cation transmembrane transporter activity
Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
sodium ion transmembrane transporter activity
Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other.
symporter activity
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
solute:cation symporter activity
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).
solute:sodium symporter activity
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in).
hydrolase activity
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
hydrolase activity, acting on ester bonds
Catalysis of the hydrolysis of any ester bond.
phosphatase activity
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
peptidase inhibitor activity
Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
active transmembrane transporter activity
Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.
inorganic cation transmembrane transporter activity
Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific transporter activity
Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
enzyme regulator activity
Modulates the activity of an enzyme.
phosphoric ester hydrolase activity
Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.
peptidase regulator activity
Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
all
NA
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
peptidase inhibitor activity
Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
endopeptidase inhibitor activity
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
solute:cation symporter activity
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).
solute:sodium symporter activity
Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in).
sodium ion transmembrane transporter activity
Catalysis of the transfer of sodium ions (Na+) from one side of a membrane to the other.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 04610 | 3.347e-09 | 0.8863 | 12 | 50 | Complement and coagulation cascades |
| 05020 | 1.589e-02 | 0.4254 | 4 | 24 | Prion diseases |
| 00830 | 1.811e-02 | 0.4432 | 4 | 25 | Retinol metabolism |
| 00982 | 2.330e-02 | 0.4786 | 4 | 27 | Drug metabolism - cytochrome P450 |
| 04060 | 3.907e-02 | 3.51 | 10 | 198 | Cytokine-cytokine receptor interaction |
ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.72 ADH4alcohol dehydrogenase 4 (class II), pi polypeptide (ENSG00000198099), score: 0.65 AFMafamin (ENSG00000079557), score: 0.65 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.67 ALG9asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae) (ENSG00000086848), score: 0.67 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.65 APCSamyloid P component, serum (ENSG00000132703), score: 0.7 APOBapolipoprotein B (including Ag(x) antigen) (ENSG00000084674), score: 0.68 AQP9aquaporin 9 (ENSG00000103569), score: 0.64 ARG1arginase, liver (ENSG00000118520), score: 0.7 ATF6activating transcription factor 6 (ENSG00000118217), score: 0.66 BAATbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) (ENSG00000136881), score: 0.7 BMP10bone morphogenetic protein 10 (ENSG00000163217), score: 0.65 BPIL1bactericidal/permeability-increasing protein-like 1 (ENSG00000078898), score: 0.82 BPIL3bactericidal/permeability-increasing protein-like 3 (ENSG00000167104), score: 0.67 BTLAB and T lymphocyte associated (ENSG00000186265), score: 0.8 C12orf35chromosome 12 open reading frame 35 (ENSG00000174718), score: 0.65 C18orf8chromosome 18 open reading frame 8 (ENSG00000141452), score: 0.65 C20orf70chromosome 20 open reading frame 70 (ENSG00000131050), score: 0.75 C4BPAcomplement component 4 binding protein, alpha (ENSG00000123838), score: 0.67 C4BPBcomplement component 4 binding protein, beta (ENSG00000123843), score: 0.64 C4orf34chromosome 4 open reading frame 34 (ENSG00000163683), score: 0.65 C5complement component 5 (ENSG00000106804), score: 0.68 C7orf53chromosome 7 open reading frame 53 (ENSG00000181016), score: 0.65 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.69 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.67 C9complement component 9 (ENSG00000113600), score: 0.7 CCR2chemokine (C-C motif) receptor 2 (ENSG00000121807), score: 0.67 CCRL2chemokine (C-C motif) receptor-like 2 (ENSG00000121797), score: 0.66 CD69CD69 molecule (ENSG00000110848), score: 0.66 CEACAM8carcinoembryonic antigen-related cell adhesion molecule 8 (ENSG00000124469), score: 0.81 CHST4carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 (ENSG00000140835), score: 0.65 CLEC4GC-type lectin domain family 4, member G (ENSG00000182566), score: 0.65 COLEC10collectin sub-family member 10 (C-type lectin) (ENSG00000184374), score: 0.69 CPceruloplasmin (ferroxidase) (ENSG00000047457), score: 0.66 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.7 CRISP3cysteine-rich secretory protein 3 (ENSG00000096006), score: 0.71 CTSWcathepsin W (ENSG00000172543), score: 0.65 CXCR6chemokine (C-X-C motif) receptor 6 (ENSG00000172215), score: 0.68 CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 8 (ENSG00000138115), score: 0.73 CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 43 (ENSG00000021461), score: 0.74 DAPP1dual adaptor of phosphotyrosine and 3-phosphoinositides (ENSG00000070190), score: 0.78 DDX60LDEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like (ENSG00000181381), score: 0.64 DHODHdihydroorotate dehydrogenase (ENSG00000102967), score: 0.75 DLG5discs, large homolog 5 (Drosophila) (ENSG00000151208), score: -0.77 ERRFI1ERBB receptor feedback inhibitor 1 (ENSG00000116285), score: 0.66 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.64 F9coagulation factor IX (ENSG00000101981), score: 0.67 FAM83Afamily with sequence similarity 83, member A (ENSG00000147689), score: 0.68 FCARFc fragment of IgA, receptor for (ENSG00000186431), score: 0.7 FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) (ENSG00000160339), score: 0.69 FETUBfetuin B (ENSG00000090512), score: 0.67 FGBfibrinogen beta chain (ENSG00000171564), score: 0.67 FGF23fibroblast growth factor 23 (ENSG00000118972), score: 0.73 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.68 FMO3flavin containing monooxygenase 3 (ENSG00000007933), score: 0.64 GAS2growth arrest-specific 2 (ENSG00000148935), score: 0.65 GCgroup-specific component (vitamin D binding protein) (ENSG00000145321), score: 0.66 GNGT1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 (ENSG00000127928), score: 0.92 GPR97G protein-coupled receptor 97 (ENSG00000182885), score: 0.75 GPX2glutathione peroxidase 2 (gastrointestinal) (ENSG00000176153), score: 0.68 GZMKgranzyme K (granzyme 3; tryptase II) (ENSG00000113088), score: 0.65 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.82 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.67 HGFhepatocyte growth factor (hepapoietin A; scatter factor) (ENSG00000019991), score: 0.71 HPS3Hermansky-Pudlak syndrome 3 (ENSG00000163755), score: 1 HPSEheparanase (ENSG00000173083), score: 0.73 HPXhemopexin (ENSG00000110169), score: 0.68 HSH2Dhematopoietic SH2 domain containing (ENSG00000196684), score: 0.65 IL18RAPinterleukin 18 receptor accessory protein (ENSG00000115607), score: 0.69 IL1RAPinterleukin 1 receptor accessory protein (ENSG00000196083), score: 0.64 IL1RNinterleukin 1 receptor antagonist (ENSG00000136689), score: 0.8 IL7Rinterleukin 7 receptor (ENSG00000168685), score: 0.65 INHBCinhibin, beta C (ENSG00000175189), score: 0.67 INSIG1insulin induced gene 1 (ENSG00000186480), score: 0.68 ITIH1inter-alpha (globulin) inhibitor H1 (ENSG00000055957), score: 0.65 ITIH3inter-alpha (globulin) inhibitor H3 (ENSG00000162267), score: 0.65 ITKIL2-inducible T-cell kinase (ENSG00000113263), score: 0.77 KIAA0146KIAA0146 (ENSG00000164808), score: 0.65 KIR3DL3killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3 (ENSG00000189013), score: 0.88 KLRD1killer cell lectin-like receptor subfamily D, member 1 (ENSG00000134539), score: 0.86 KRT27keratin 27 (ENSG00000171446), score: 0.83 LBPlipopolysaccharide binding protein (ENSG00000129988), score: 0.67 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.69 LONP2lon peptidase 2, peroxisomal (ENSG00000102910), score: 0.69 LRG1leucine-rich alpha-2-glycoprotein 1 (ENSG00000171236), score: 0.67 MLANAmelan-A (ENSG00000120215), score: 0.81 MMP8matrix metallopeptidase 8 (neutrophil collagenase) (ENSG00000118113), score: 0.89 MSMBmicroseminoprotein, beta- (ENSG00000138294), score: 0.78 MTHFD2Lmethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like (ENSG00000163738), score: 0.96 NCR1natural cytotoxicity triggering receptor 1 (ENSG00000189430), score: 0.87 NF2neurofibromin 2 (merlin) (ENSG00000186575), score: -0.7 NFE2nuclear factor (erythroid-derived 2), 45kDa (ENSG00000123405), score: 0.68 NFIL3nuclear factor, interleukin 3 regulated (ENSG00000165030), score: 0.7 NLRP12NLR family, pyrin domain containing 12 (ENSG00000142405), score: 0.86 NNMTnicotinamide N-methyltransferase (ENSG00000166741), score: 0.69 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.72 NRBF2nuclear receptor binding factor 2 (ENSG00000148572), score: 0.81 OATornithine aminotransferase (ENSG00000065154), score: 0.69 OIT3oncoprotein induced transcript 3 (ENSG00000138315), score: 0.72 ORM1orosomucoid 1 (ENSG00000229314), score: 0.68 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.67 PF4platelet factor 4 (ENSG00000163737), score: 0.81 PON1paraoxonase 1 (ENSG00000005421), score: 0.69 PON3paraoxonase 3 (ENSG00000105852), score: 0.65 PPBPpro-platelet basic protein (chemokine (C-X-C motif) ligand 7) (ENSG00000163736), score: 0.85 PRLprolactin (ENSG00000172179), score: 0.75 PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (ENSG00000134242), score: 0.73 PTPRCprotein tyrosine phosphatase, receptor type, C (ENSG00000081237), score: 0.64 RASGEF1BRasGEF domain family, member 1B (ENSG00000138670), score: 0.66 RDH16retinol dehydrogenase 16 (all-trans) (ENSG00000139547), score: 0.66 RGS18regulator of G-protein signaling 18 (ENSG00000150681), score: 0.72 RND3Rho family GTPase 3 (ENSG00000115963), score: 0.64 S100A12S100 calcium binding protein A12 (ENSG00000163221), score: 0.68 SCGB3A2secretoglobin, family 3A, member 2 (ENSG00000164265), score: 0.75 SEC14L3SEC14-like 3 (S. cerevisiae) (ENSG00000100012), score: 0.68 SELLselectin L (ENSG00000188404), score: 0.74 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.76 SERPINA11serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 (ENSG00000186910), score: 0.69 SERPINA4serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 (ENSG00000100665), score: 0.65 SERPINA7serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (ENSG00000123561), score: 0.69 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.65 SIAH2seven in absentia homolog 2 (Drosophila) (ENSG00000181788), score: 0.71 SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (ENSG00000100652), score: 0.68 SLC13A5solute carrier family 13 (sodium-dependent citrate transporter), member 5 (ENSG00000141485), score: 0.72 SLC17A2solute carrier family 17 (sodium phosphate), member 2 (ENSG00000112337), score: 0.64 SLC20A1solute carrier family 20 (phosphate transporter), member 1 (ENSG00000144136), score: 0.67 SLC22A1solute carrier family 22 (organic cation transporter), member 1 (ENSG00000175003), score: 0.65 SLC25A38solute carrier family 25, member 38 (ENSG00000144659), score: 0.68 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.64 SLC28A3solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 (ENSG00000197506), score: 0.82 SLC5A6solute carrier family 5 (sodium-dependent vitamin transporter), member 6 (ENSG00000138074), score: 0.65 SPINK1serine peptidase inhibitor, Kazal type 1 (ENSG00000164266), score: 0.64 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.76 STAB2stabilin 2 (ENSG00000136011), score: 0.65 SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (ENSG00000105398), score: 0.77 TATtyrosine aminotransferase (ENSG00000198650), score: 0.73 TBC1D14TBC1 domain family, member 14 (ENSG00000132405), score: -0.74 TCN1transcobalamin I (vitamin B12 binding protein, R binder family) (ENSG00000134827), score: 0.98 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.75 TGDSTDP-glucose 4,6-dehydratase (ENSG00000088451), score: 0.73 TIGD2tigger transposable element derived 2 (ENSG00000180346), score: 0.66 TIGITT cell immunoreceptor with Ig and ITIM domains (ENSG00000181847), score: 0.79 TLR8toll-like receptor 8 (ENSG00000101916), score: 0.7 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.64 TMC3transmembrane channel-like 3 (ENSG00000188869), score: 0.65 TMED6transmembrane emp24 protein transport domain containing 6 (ENSG00000157315), score: 0.75 TMEM120Btransmembrane protein 120B (ENSG00000188735), score: -0.67 TMEM45Atransmembrane protein 45A (ENSG00000181458), score: 0.68 TOB1transducer of ERBB2, 1 (ENSG00000141232), score: 0.76 TOM1L2target of myb1-like 2 (chicken) (ENSG00000175662), score: -0.66 TRAT1T cell receptor associated transmembrane adaptor 1 (ENSG00000163519), score: 0.68 TRIB1tribbles homolog 1 (Drosophila) (ENSG00000173334), score: 0.66 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.63 TXNDC12thioredoxin domain containing 12 (endoplasmic reticulum) (ENSG00000117862), score: 0.7 UNC93Aunc-93 homolog A (C. elegans) (ENSG00000112494), score: 0.66 VNN2vanin 2 (ENSG00000112303), score: 0.76 ZBTB4zinc finger and BTB domain containing 4 (ENSG00000174282), score: -0.67
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| ppa_lv_m_ca1 | ppa | lv | m | _ |
| ppy_lv_m_ca1 | ppy | lv | m | _ |
| ppa_lv_f_ca1 | ppa | lv | f | _ |
| ppy_lv_f_ca1 | ppy | lv | f | _ |
