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sulfur amino acid metabolic process

The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.

sulfur metabolic process

The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.

metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

response to molecule of bacterial origin

A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.

adaptive immune response

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).

immune effector process

Any process of the immune system that occurs as part of an immune response.

activation of immune response

Any process that initiates an immune response.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

leukocyte mediated immunity

Any process involved in the carrying out of an immune response by a leukocyte.

lymphocyte mediated immunity

Any process involved in the carrying out of an immune response by a lymphocyte.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.

acute inflammatory response

Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

protein maturation by peptide bond cleavage

The hydrolysis of a peptide bond or bonds within a protein as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

cysteine metabolic process

The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

cellular aromatic compound metabolic process

The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

humoral immune response

An immune response mediated through a body fluid.

digestion

The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

hemostasis

The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

cytolysis

The rupture of cell membranes and the loss of cytoplasm.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

amine catabolic process

The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

detection of chemical stimulus

The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.

detection of biotic stimulus

The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to biotic stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

response to other organism

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.

response to bacterium

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to extracellular stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.

response to organic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

response to inorganic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.

gene expression

The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

regulation of hormone levels

Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.

lipid localization

Any process by which a lipid is transported to, or maintained in, a specific location.

sterol transport

The directed movement of sterols into, out of, within or between cells by means of some external agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

immunoglobulin mediated immune response

An immune response mediated by immunoglobulins, whether cell-bound or in solution.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

death

A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism.

protein processing

Any protein maturation process achieved by the cleavage of peptide bonds.

response to arsenic

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.

organic ether metabolic process

The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

digestive system process

A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

intestinal cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

cholesterol transport

The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of, within or between cells by means of some external agent such as a transporter or pore.

response to nutrient levels

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

detection of molecule of bacterial origin

The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

macromolecule localization

Any process by which a macromolecule is transported to, or maintained in, a specific location.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

cholesterol homeostasis

Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.

fibrinolysis

An ongoing process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, resulting in the removal of small blood clots.

macromolecule metabolic process

The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cellular amide metabolic process

The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.

amide biosynthetic process

The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

lipid digestion

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

heterocycle metabolic process

The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

coagulation

The process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

intestinal absorption

Any process by which nutrients are taken up from the contents of the intestine.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

detection of stimulus

The series of events in which a stimulus is received by a cell or organism and converted into a molecular signal.

multi-organism process

Any process by which an organism has an effect on another organism of the same or different species.

regulation of fibrinolysis

Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

lipid homeostasis

Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.

sterol homeostasis

Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

cell death

A biological process that results in permanent cessation of all vital functions of a cell.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

negative regulation of biological process

Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular biosynthetic process

The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

protein metabolic process

The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

positive regulation of immune system process

Any process that activates or increases the frequency, rate, or extent of an immune system process.

immune effector process

Any process of the immune system that occurs as part of an immune response.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

digestive system process

A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.

regulation of coagulation

Any process that modulates the frequency, rate or extent of coagulation, the process by which a fluid solution, or part of it, changes into a solid or semisolid mass.

positive regulation of multicellular organismal process

Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

negative regulation of multicellular organismal process

Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

positive regulation of response to stimulus

Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of immune response

Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

regulation of response to stress

Any process that modulates the frequency, rate or extent of a response to stress. Response to stress is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

regulation of response to external stimulus

Any process that modulates the frequency, rate or extent of a response to an external stimulus.

response to other organism

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from another living organism.

detection of chemical stimulus

The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.

detection of biotic stimulus

The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

cellular nitrogen compound biosynthetic process

The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.

protein maturation

Any process leading to the attainment of the full functional capacity of a protein.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular lipid metabolic process

The chemical reactions and pathways involving lipids, as carried out by individual cells.

positive regulation of immune response

Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

activation of immune response

Any process that initiates an immune response.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

complement activation, alternative pathway

Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

negative regulation of coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of coagulation.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

positive regulation of coagulation

Any process that activates or increases the frequency, rate or extent of coagulation.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

innate immune response

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

detection of molecule of bacterial origin

The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal.

detection of molecule of bacterial origin

The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal.

response to molecule of bacterial origin

A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.

lipid transport

The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

response to molecule of bacterial origin

A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.

hormone metabolic process

The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

amide biosynthetic process

The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.

sulfur amino acid metabolic process

The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

steroid biosynthetic process

The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

sterol biosynthetic process

The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

B cell mediated immunity

Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.

complement activation, classical pathway

Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.

intestinal cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

positive regulation of blood coagulation

Any process that activates or increases the frequency, rate or extent of blood coagulation.

negative regulation of blood coagulation

Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation.

regulation of blood coagulation

Any process that modulates the frequency, rate or extent of blood coagulation.

blood coagulation

The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.

regulation of wound healing

Any process that modulates the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

cysteine metabolic process

The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid.

cholesterol biosynthetic process

The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.

regulation of fibrinolysis

Any process that modulates the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.

intestinal cholesterol absorption

Uptake of cholesterol into the blood by absorption from the small intestine.

activation of plasma proteins involved in acute inflammatory response

Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.

humoral immune response mediated by circulating immunoglobulin

An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.

complement activation

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

cell fraction

A generic term for parts of cells prepared by disruptive biochemical techniques.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

membrane fraction

That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes.

insoluble fraction

That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

microsome

Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g.

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

protein-lipid complex

A macromolecular complex containing both protein and lipid molecules.

plasma lipoprotein particle

A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

vesicular fraction

Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

all

NA

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

plasma lipoprotein particle

A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma lipoprotein particle

A spherical particle with a hydrophobic core of triglycerides and/or cholesterol esters, surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Plasma lipoprotein particles transport lipids, which are non-covalently associated with the particles, in the blood or lymph.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

enzyme inhibitor activity

Stops, prevents or reduces the activity of an enzyme.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

serine-type endopeptidase inhibitor activity

Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

steroid binding

Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.

lipid binding

Interacting selectively and non-covalently with a lipid.

endopeptidase regulator activity

Modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

transferase activity

Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

transferase activity, transferring nitrogenous groups

Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor).

lyase activity

Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

carbon-sulfur lyase activity

Catalysis of the elimination of H2S or substituted H2S.

1-aminocyclopropane-1-carboxylate synthase activity

Catalysis of the reaction: S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

vitamin binding

Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

enzyme regulator activity

Modulates the activity of an enzyme.

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

amine binding

Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.

protein dimerization activity

The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

cofactor binding

Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

peptidase regulator activity

Modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

vitamin B6 binding

Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.

all

NA

amino acid binding

Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.

peptidase inhibitor activity

Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

endopeptidase inhibitor activity

Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0009611	5.332e-12	14.52	50 ADRB2, AOAH, ATRN, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCL23, CCL24, CCR7, CD180, CDO1, CFP, CPB2, CXCR2, CYP1A1, F2, F2RL2, F7, F9, FCN2, FGB, GGCX, HRG, IGF1, IGFBP1, IL10RA, IL2, ITIH4, KLKB1, LBP, MASP2, NFAM1, PLA2G2D, PROZ, SCARB1, SDC2, SERPINC1, SERPIND1, SIGLEC1, SLC11A1, TLR1, TLR6, TM4SF4, TPST1, VSIG4	494	response to wounding
GO:0008202	7.274e-11	5.113	28 AFP, AKR1D1, APOA4, APOB, APOF, BAAT, CAT, COMT, CYP17A1, CYP1A1, ESR1, HMGCS2, INSIG1, LDLR, MVD, NPC1L1, NR1I2, NR5A2, NSDHL, OSBPL11, PCSK9, SCARB1, SERPINA6, SIGMAR1, SOAT2, STARD5, SULT2A1, TM7SF2	174	steroid metabolic process
GO:0044281	1.065e-09	38.58	83 ACOT12, ACOX1, ADH4, ADRB2, AGFG2, AGXT, AKR1D1, AMDHD1, APOA4, APOB, APOF, ARAP1, ARFGAP2, ARG1, ART4, AS3MT, BAAT, CAT, CCBL1, CCL24, CDIPT, CDO1, COMT, CTH, CYP1A1, DPYD, ELOVL2, FGD2, FPGS, GCAT, GCK, GCLC, GHR, GK5, GNE, GNMT, GPAM, GPT, GUCA2B, GYS2, H6PD, HAO1, HMGCS2, IGF1, INSIG1, IVD, LDLR, MAT1A, MCFD2, MTHFD1, MVD, NADK, NPC1L1, NR5A2, NSDHL, NT5M, ONECUT1, OTC, PAPSS1, PCSK9, PEMT, PFKFB1, PKD2, PON1, PRHOXNB, PYGL, RBP1, SCARB1, SDS, SERPINA12, SIGMAR1, SLC19A3, SLC25A15, SLC7A6, SOAT2, SULT2A1, TAT, TDO2, TM7SF2, TMEM195, TTPA, UROC1, XDH	1313	small molecule metabolic process
GO:0006952	1.376e-09	15.34	47 ADRB2, AOAH, APOA4, ATRN, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCL23, CCL24, CCR7, CD180, CD1D, CD5L, CDO1, CFP, CXCR2, F2, FCN2, GPAM, HCK, HPX, IL2, INHBA, ITIH4, KLKB1, LBP, MARCO, MASP2, NFAM1, PGLYRP2, PLA2G2D, RNASE6, SARM1, SERPINC1, SIGLEC1, SLC11A1, STAB2, TLR1, TLR6, TNFAIP8L2, TPST1, VSIG4	522	defense response
GO:0002541	3.493e-09	0.8521	12 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFP, FCN2, KLKB1, MASP2, VSIG4	29	activation of plasma proteins involved in acute inflammatory response
GO:0006954	6.252e-09	9.05	34 ADRB2, AOAH, ATRN, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCL23, CCL24, CCR7, CD180, CDO1, CFP, CXCR2, F2, FCN2, IL2, ITIH4, KLKB1, LBP, MASP2, NFAM1, PLA2G2D, SERPINC1, SIGLEC1, SLC11A1, TLR1, TLR6, TPST1, VSIG4	308	inflammatory response
GO:0050896	6.375e-09	74.25	126 ABCA4, ABCG5, ACP2, ADRB2, AFP, AGXT, AIM2, ALG2, AMBP, AOAH, APOA4, APOB, AQP9, AS3MT, ATRN, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CAT, CCL23, CCL24, CCR7, CD180, CD1B, CD1C, CD1D, CD1E, CD5L, CDO1, CFP, CIDEB, CNIH, COMT, CPB2, CPOX, CREB3L3, CXCR2, CXCR3, CYP17A1, CYP1A1, DDOST, DNAJA4, DUSP10, EDEM1, ENDOG, EPHX1, ESR1, F2, F2RL2, F7, F9, FCN2, FGB, FOXA1, FOXA3, FOXP3, FPR3, GCK, GCLC, GGCX, GHR, GNAT1, GPAM, GYS2, HAO1, HCK, HMGCS2, HPX, HRG, IGF1, IGFBP1, IGSF6, IL10RA, IL1R2, IL2, INHBA, INSIG1, ITGAD, ITIH4, KLKB1, LBP, LDLR, LECT2, MARCO, MASP2, MVD, NFAM1, NR1I2, NYX, OR10H3, P2RX3, PCSK9, PEMT, PFKFB1, PGLYRP2, PKD2, PLA2G2D, PON1, PROZ, RNASE6, SARM1, SCARB1, SDC2, SDS, SERPINA7, SERPINC1, SERPIND1, SIGLEC1, SLC11A1, SOAT2, STAB2, TAT, TGFBI, TLR1, TLR6, TM4SF4, TNFAIP8L2, TPST1, TRPM1, TTPA, VSIG4	2527	response to stimulus
GO:0019752	1.329e-08	14.16	43 ACOT12, ACOX1, AGXT, AKR1D1, AMDHD1, APOA4, ARG1, ART4, AS3MT, BAAT, CCBL1, CDO1, COMT, CTH, CYP1A1, ELOVL2, FPGS, GCAT, GCK, GCLC, GHR, GNE, GNMT, GPAM, GPT, HAO1, IGF1, IVD, MAT1A, MCFD2, MTHFD1, NR5A2, OTC, PFKFB1, PON1, SDS, SLC25A15, SLC7A6, SULT2A1, TAT, TDO2, TMEM195, UROC1	482	carboxylic acid metabolic process
GO:0043436	1.329e-08	14.16	43 ACOT12, ACOX1, AGXT, AKR1D1, AMDHD1, APOA4, ARG1, ART4, AS3MT, BAAT, CCBL1, CDO1, COMT, CTH, CYP1A1, ELOVL2, FPGS, GCAT, GCK, GCLC, GHR, GNE, GNMT, GPAM, GPT, HAO1, IGF1, IVD, MAT1A, MCFD2, MTHFD1, NR5A2, OTC, PFKFB1, PON1, SDS, SLC25A15, SLC7A6, SULT2A1, TAT, TDO2, TMEM195, UROC1	482	oxoacid metabolic process
GO:0006956	1.639e-08	0.764	11 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFP, FCN2, MASP2, VSIG4	26	complement activation
GO:0006082	1.693e-08	14.28	43 ACOT12, ACOX1, AGXT, AKR1D1, AMDHD1, APOA4, ARG1, ART4, AS3MT, BAAT, CCBL1, CDO1, COMT, CTH, CYP1A1, ELOVL2, FPGS, GCAT, GCK, GCLC, GHR, GNE, GNMT, GPAM, GPT, HAO1, IGF1, IVD, MAT1A, MCFD2, MTHFD1, NR5A2, OTC, PFKFB1, PON1, SDS, SLC25A15, SLC7A6, SULT2A1, TAT, TDO2, TMEM195, UROC1	486	organic acid metabolic process
GO:0042180	2.380e-08	14.46	43 ACOT12, ACOX1, AGXT, AKR1D1, AMDHD1, APOA4, ARG1, ART4, AS3MT, BAAT, CCBL1, CDO1, COMT, CTH, CYP1A1, ELOVL2, FPGS, GCAT, GCK, GCLC, GHR, GNE, GNMT, GPAM, GPT, HAO1, IGF1, IVD, MAT1A, MCFD2, MTHFD1, NR5A2, OTC, PFKFB1, PON1, SDS, SLC25A15, SLC7A6, SULT2A1, TAT, TDO2, TMEM195, UROC1	492	cellular ketone metabolic process
GO:0006629	2.682e-08	20.57	53 ACER1, ACOT12, ACOX1, ADH4, AFP, AKR1D1, AOAH, APOA4, APOB, APOF, BAAT, CAT, CDIPT, COMT, CYP17A1, CYP1A1, ELOVL2, ESR1, GHR, GNE, GPAM, GPLD1, HAO1, HMGCS2, INSIG1, LDLR, LIPM, MVD, NAAA, NAGA, NPC1L1, NR1I2, NR5A2, NSDHL, OSBPL11, PCSK9, PCYT2, PEMT, PLA2G2D, PON1, RBP1, RDH16, SCARB1, SERPINA6, SIGMAR1, SLC35C1, SMPDL3A, SOAT2, STARD5, SULT2A1, TM7SF2, TMEM195, TTPA	700	lipid metabolic process
GO:0045087	8.628e-08	4.819	23 APOA4, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD180, CD1D, CFP, FCN2, HPX, LBP, MARCO, MASP2, PGLYRP2, SARM1, SLC11A1, TLR1, TLR6, TNFAIP8L2, VSIG4	164	innate immune response
GO:0009308	2.580e-07	9.491	32 AGXT, AMDHD1, APOA4, ARG1, ART4, BAAT, CCBL1, CDO1, COMT, CTH, CYP1A1, GCAT, GCLC, GHR, GNMT, ITIH1, ITIH3, ITIH4, IVD, MAT1A, MTHFD1, OTC, PEMT, PGLYRP2, PON1, PRHOXNB, SDS, SLC25A15, SLC7A6, TAT, TDO2, UROC1	323	amine metabolic process
GO:0016125	2.793e-07	2.409	16 AKR1D1, APOA4, APOB, APOF, CAT, HMGCS2, INSIG1, LDLR, MVD, NPC1L1, NSDHL, PCSK9, SCARB1, SIGMAR1, SOAT2, TM7SF2	82	sterol metabolic process
GO:0051605	4.722e-07	1.851	14 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFP, FCN2, KLKB1, MASP2, PCSK6, PCSK9, VSIG4	63	protein maturation by peptide bond cleavage
GO:0006520	5.549e-07	5.348	23 AGXT, AMDHD1, ARG1, ART4, BAAT, CCBL1, CDO1, COMT, CTH, GCAT, GCLC, GHR, GNMT, IVD, MAT1A, MTHFD1, OTC, SDS, SLC25A15, SLC7A6, TAT, TDO2, UROC1	182	cellular amino acid metabolic process
GO:0006066	6.862e-07	11.02	34 ADH4, AKR1D1, APOA4, APOB, APOF, CAT, COMT, GCK, GK5, GNE, GNMT, GPT, GYS2, H6PD, HAO1, HMGCS2, IGF1, INSIG1, LDLR, MVD, NPC1L1, NSDHL, ONECUT1, PCSK9, PEMT, PFKFB1, PON1, PYGL, SCARB1, SDS, SERPINA12, SIGMAR1, SOAT2, TM7SF2	375	alcohol metabolic process
GO:0008203	6.958e-07	2.233	15 AKR1D1, APOA4, APOB, APOF, CAT, HMGCS2, INSIG1, LDLR, MVD, NPC1L1, NSDHL, PCSK9, SCARB1, SOAT2, TM7SF2	76	cholesterol metabolic process
GO:0006957	8.607e-07	0.3232	7 C5, C8A, C8B, C8G, C9, CFP, VSIG4	11	complement activation, alternative pathway
GO:0006950	8.656e-07	42.4	80 ADRB2, AMBP, AOAH, APOA4, AQP9, ATRN, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CAT, CCL23, CCL24, CCR7, CD180, CD1D, CD5L, CDO1, CFP, CIDEB, COMT, CPB2, CREB3L3, CXCR2, CYP1A1, DNAJA4, DUSP10, EDEM1, F2, F2RL2, F7, F9, FCN2, FGB, FOXA3, GCLC, GGCX, GPAM, HAO1, HCK, HPX, HRG, IGF1, IGFBP1, IL10RA, IL2, INHBA, INSIG1, ITIH4, KLKB1, LBP, MARCO, MASP2, NFAM1, P2RX3, PCSK9, PFKFB1, PGLYRP2, PLA2G2D, PROZ, RNASE6, SARM1, SCARB1, SDC2, SERPINC1, SERPIND1, SIGLEC1, SLC11A1, STAB2, TAT, TLR1, TLR6, TM4SF4, TNFAIP8L2, TPST1, VSIG4	1443	response to stress
GO:0002526	9.720e-07	2.292	15 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFP, F2, FCN2, ITIH4, KLKB1, LBP, MASP2, VSIG4	78	acute inflammatory response
GO:0044106	1.264e-06	7.052	26 AGXT, AMDHD1, APOA4, ARG1, ART4, BAAT, CCBL1, CDO1, COMT, CTH, GCAT, GCLC, GHR, GNMT, IVD, MAT1A, MTHFD1, OTC, PEMT, PON1, SDS, SLC25A15, SLC7A6, TAT, TDO2, UROC1	240	cellular amine metabolic process
GO:0006958	1.470e-06	0.4995	8 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, MASP2	17	complement activation, classical pathway
GO:0002253	1.563e-06	2.38	15 C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFP, FCN2, LBP, MASP2, NFAM1, TLR6, VSIG4	81	activation of immune response
GO:0009605	2.043e-06	15.75	41 ABCA4, ABCG5, ADRB2, C3AR1, C5, CCL23, CCL24, CCR7, CD1D, CPB2, CXCR2, CXCR3, CYP1A1, F2, F7, FOXA3, FPR3, GGCX, GHR, GNAT1, GPAM, HMGCS2, HRG, IL2, KLKB1, LBP, LECT2, PCSK9, PEMT, PFKFB1, PGLYRP2, PKD2, PON1, SDS, SERPINA7, SERPINC1, SERPIND1, SOAT2, TLR1, TLR6, TTPA	536	response to external stimulus
GO:0006955	2.732e-06	15.31	40 AIM2, AMBP, APOA4, AQP9, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCL23, CCL24, CCR7, CD180, CD1B, CD1C, CD1D, CD1E, CFP, CNIH, FCN2, FOXP3, GPAM, HPX, IGSF6, IL1R2, IL2, ITGAD, LBP, MARCO, MASP2, PGLYRP2, SARM1, SLC11A1, TLR1, TLR6, TNFAIP8L2, VSIG4	521	immune response
GO:0050778	2.750e-06	3.643	18 C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD1D, CFP, FCN2, HPX, LBP, MASP2, NFAM1, SLC11A1, TLR6, VSIG4	124	positive regulation of immune response
GO:0042221	2.810e-06	33.79	67 ABCG5, ACP2, AFP, AGXT, ALG2, APOA4, APOB, AQP9, AS3MT, ATRN, C3AR1, C5, CAT, CCL23, CCL24, CCR7, CDO1, COMT, CPB2, CPOX, CREB3L3, CXCR2, CXCR3, CYP17A1, CYP1A1, DDOST, EDEM1, ENDOG, EPHX1, ESR1, F7, FGB, FOXA1, FPR3, GCK, GCLC, GGCX, GHR, GPAM, GYS2, HAO1, HMGCS2, HPX, IGFBP1, IL10RA, LBP, LDLR, LECT2, MVD, NR1I2, P2RX3, PCSK9, PEMT, PFKFB1, PON1, SCARB1, SDC2, SDS, SERPINA7, SERPINC1, SERPIND1, SLC11A1, SOAT2, TAT, TLR1, TLR6, TTPA	1150	response to chemical stimulus
GO:0002455	3.898e-06	0.764	9 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX, MASP2	26	humoral immune response mediated by circulating immunoglobulin
GO:0042060	4.338e-06	5.083	21 C4BPB, C9, CPB2, F2, F2RL2, F7, F9, FGB, GGCX, HRG, IGF1, IGFBP1, IL10RA, KLKB1, PROZ, SCARB1, SDC2, SERPINC1, SERPIND1, SLC11A1, TM4SF4	173	wound healing
GO:0006519	4.563e-06	8.08	27 AGXT, AMDHD1, APOA4, ARG1, ART4, BAAT, CCBL1, CDO1, COMT, CTH, CYP1A1, GCAT, GCLC, GHR, GNMT, IVD, MAT1A, MTHFD1, OTC, PEMT, PON1, SDS, SLC25A15, SLC7A6, TAT, TDO2, UROC1	275	cellular amino acid and derivative metabolic process
GO:0065008	5.775e-06	39.78	74 A1CF, ABCG5, ADH4, ADRB2, AFP, AKR1D1, APOA4, APOB, AQP9, ARAP1, C3AR1, C4BPB, C9, CCL23, CCL24, CCR7, CDO1, COMT, CP, CPB2, CTH, CXCR3, CYP17A1, CYP1A1, DSC3, ESR1, F2, F2RL2, F7, F9, FGB, FGD2, FOXA1, FOXA3, FOXP3, FST, GCK, GCKR, GCLC, GDF2, GGCX, GPAM, GUCA2B, HPX, HRG, IGF1, IGFBP1, IL10RA, IL2, INHBA, KLKB1, LDLR, NPC1L1, NR5A2, OTC, P2RX3, PCSK6, PCSK9, PFN2, PKD2, PRDM4, PROZ, PYGL, SCARB1, SERPINA6, SERPINC1, SERPIND1, SLC11A1, SLC16A2, SLC9A8, SOAT2, TFR2, TLR6, XDH	1354	regulation of biological quality
GO:0007596	1.488e-05	2.85	15 C4BPB, C9, CPB2, F2, F2RL2, F7, F9, FGB, GGCX, HRG, IL10RA, KLKB1, PROZ, SERPINC1, SERPIND1	97	blood coagulation
GO:0016485	1.496e-05	2.468	14 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFP, FCN2, KLKB1, MASP2, PCSK6, PCSK9, VSIG4	84	protein processing
GO:0050817	1.892e-05	2.909	15 C4BPB, C9, CPB2, F2, F2RL2, F7, F9, FGB, GGCX, HRG, IL10RA, KLKB1, PROZ, SERPINC1, SERPIND1	99	coagulation
GO:0006959	2.095e-05	1.822	12 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFP, FCN2, HPX, MASP2, VSIG4	62	humoral immune response
GO:0050776	2.172e-05	5.642	21 AMBP, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD1D, CFP, FCN2, FOXP3, HPX, IL2, LBP, MASP2, NFAM1, SLC11A1, TLR6, VSIG4	192	regulation of immune response
GO:0007599	2.695e-05	2.997	15 C4BPB, C9, CPB2, F2, F2RL2, F7, F9, FGB, GGCX, HRG, IL10RA, KLKB1, PROZ, SERPINC1, SERPIND1	102	hemostasis
GO:0051604	2.881e-05	2.615	14 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFP, FCN2, KLKB1, MASP2, PCSK6, PCSK9, VSIG4	89	protein maturation
GO:0044282	3.520e-05	9.608	28 ACOX1, ADH4, AGFG2, AKR1D1, AMDHD1, ARAP1, ARFGAP2, ARG1, CCL24, CDO1, COMT, DPYD, FGD2, GCK, H6PD, HAO1, IGF1, IVD, MTHFD1, NT5M, PFKFB1, PON1, SDS, SULT2A1, TAT, TDO2, UROC1, XDH	327	small molecule catabolic process
GO:0042632	3.960e-05	0.999	9 ABCG5, APOA4, APOB, LDLR, NPC1L1, NR5A2, PCSK9, SCARB1, SOAT2	34	cholesterol homeostasis
GO:0055092	3.960e-05	0.999	9 ABCG5, APOA4, APOB, LDLR, NPC1L1, NR5A2, PCSK9, SCARB1, SOAT2	34	sterol homeostasis
GO:0055088	4.184e-05	1.293	10 ABCG5, APOA4, APOB, GPAM, LDLR, NPC1L1, NR5A2, PCSK9, SCARB1, SOAT2	44	lipid homeostasis
GO:0016054	6.679e-05	2.821	14 ACOX1, AKR1D1, AMDHD1, ARG1, CDO1, HAO1, IVD, MTHFD1, PON1, SDS, SULT2A1, TAT, TDO2, UROC1	96	organic acid catabolic process
GO:0046395	6.679e-05	2.821	14 ACOX1, AKR1D1, AMDHD1, ARG1, CDO1, HAO1, IVD, MTHFD1, PON1, SDS, SULT2A1, TAT, TDO2, UROC1	96	carboxylic acid catabolic process
GO:0006725	7.226e-05	3.261	15 COMT, CYP1A1, DPYD, EPHX1, FPGS, GNMT, MOCOS, MTHFD1, PEMT, PON1, PRHOXNB, SLC19A3, TAT, TDO2, XDH	111	cellular aromatic compound metabolic process
GO:0030299	9.679e-05	0.2351	5 ABCG5, APOA4, LDLR, NPC1L1, SOAT2	8	intestinal cholesterol absorption
GO:0050878	9.684e-05	4.731	18 C4BPB, C9, CDO1, CPB2, F2, F2RL2, F7, F9, FGB, GGCX, GUCA2B, HRG, IL10RA, KLKB1, PROZ, SERPINC1, SERPIND1, XDH	161	regulation of body fluid levels
GO:0006790	1.285e-04	2.997	14 CDO1, COMT, CTH, GCLC, GHR, GNMT, HS3ST3B1, IGF1, MTHFD1, PAPSS1, PEMT, SLC19A3, SULT2A1, TPST1	102	sulfur metabolic process
GO:0002684	1.296e-04	6.376	21 C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD1D, CFP, F7, FCN2, GPAM, HPX, IL2, LBP, MASP2, NFAM1, SLC11A1, TLR6, VSIG4	217	positive regulation of immune system process
GO:0044241	1.935e-04	0.2644	5 ABCG5, APOA4, LDLR, NPC1L1, SOAT2	9	lipid digestion
GO:0009069	1.951e-04	0.4407	6 AGXT, BAAT, CDO1, CTH, GCLC, SDS	15	serine family amino acid metabolic process
GO:0048878	2.013e-04	13.1	32 ABCG5, APOA4, APOB, AQP9, C3AR1, CCL23, CCR7, CP, CXCR3, F2, FOXA1, FOXA3, GCK, GCKR, GCLC, GPAM, HPX, IGF1, IL2, LDLR, NPC1L1, NR5A2, OTC, P2RX3, PCSK9, PKD2, PYGL, SCARB1, SLC11A1, SLC9A8, SOAT2, TFR2	446	chemical homeostasis
GO:0002376	2.051e-04	24.06	48 AIM2, AMBP, APOA4, AQP9, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCL23, CCL24, CCR7, CD180, CD1B, CD1C, CD1D, CD1E, CFP, CNIH, CXCR2, DDOST, F7, FCN2, FOXP3, FST, GPAM, HPX, IGSF6, IL1R2, IL2, INHBA, ITGAD, ITIH1, LBP, MARCO, MASP2, NFAM1, ONECUT1, PGLYRP2, SARM1, SLC11A1, TLR1, TLR6, TNFAIP8L2, VSIG4	819	immune system process
GO:0016064	2.069e-04	1.557	10 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX, IL2, MASP2	53	immunoglobulin mediated immune response
GO:0002460	2.299e-04	2.733	13 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, FOXP3, HPX, IL2, MASP2, SLC11A1, TLR6	93	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0019724	2.427e-04	1.587	10 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, HPX, IL2, MASP2	54	B cell mediated immunity
GO:0002250	2.850e-04	2.791	13 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, FOXP3, HPX, IL2, MASP2, SLC11A1, TLR6	95	adaptive immune response
GO:0009310	4.391e-04	1.704	10 AMDHD1, ARG1, CDO1, COMT, IVD, MTHFD1, SDS, TAT, TDO2, UROC1	58	amine catabolic process
GO:0002252	4.749e-04	4.848	17 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CFP, FCN2, FOXP3, GPAM, HPX, IL2, LBP, MASP2, SLC11A1, VSIG4	165	immune effector process
GO:0002449	5.613e-04	2.556	12 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, FOXP3, HPX, IL2, MASP2, SLC11A1	87	lymphocyte mediated immunity
GO:0051186	5.863e-04	4.936	17 ACOT12, ADH4, ALAS1, AMBP, BAAT, CPOX, CTH, CYP1A1, FPGS, GCLC, GPAM, H6PD, HPX, MOCOS, MTHFD1, NADK, TDO2	168	cofactor metabolic process
GO:0006869	5.880e-04	3.937	15 ABCA4, ABCG5, APOA4, APOB, APOF, INHBA, LBP, LDLR, NPC1L1, OSBPL11, PON1, SCARB1, SIGMAR1, SOAT2, STARD5	134	lipid transport
GO:0000096	7.767e-04	0.5583	6 CDO1, COMT, CTH, GCLC, GNMT, MTHFD1	19	sulfur amino acid metabolic process
GO:0009595	7.767e-04	0.5583	6 CD1D, LBP, PGLYRP2, SCARB1, TLR1, TLR6	19	detection of biotic stimulus
GO:0050892	8.921e-04	0.3526	5 ABCG5, APOA4, LDLR, NPC1L1, SOAT2	12	intestinal absorption
GO:0009056	1.124e-03	27.38	50 ACER1, ACOX1, ADH4, AGFG2, AKR1D1, AMBP, AMDHD1, APOA4, APOB, ARAP1, ARFGAP2, ARG1, CAT, CCL24, CDO1, COMT, CYP1A1, DPYD, EDEM1, ENDOG, EPHX1, FGD2, GCK, GCLC, H6PD, HAO1, IGF1, IVD, LDLR, LIPM, MTHFD1, NAGA, NR1I2, NT5M, PCSK9, PFKFB1, PGLYRP2, PLA2G2D, PON1, PSMB2, PYGL, RNASE6, SCARB1, SDS, SMPDL3A, SULT2A1, TAT, TDO2, UROC1, XDH	932	catabolic process
GO:0009063	1.229e-03	1.557	9 AMDHD1, ARG1, CDO1, IVD, MTHFD1, SDS, TAT, TDO2, UROC1	53	cellular amino acid catabolic process
GO:0043603	1.325e-03	0.382	5 ARG1, GHR, OTC, PRHOXNB, SLC25A15	13	cellular amide metabolic process
GO:0032490	1.395e-03	0.2057	4 LBP, SCARB1, TLR1, TLR6	7	detection of molecule of bacterial origin
GO:0043604	1.395e-03	0.2057	4 ARG1, OTC, PRHOXNB, SLC25A15	7	amide biosynthetic process
GO:0034754	1.406e-03	1.587	9 ADH4, AFP, AKR1D1, COMT, CYP17A1, CYP1A1, ESR1, SCARB1, SERPINA6	54	cellular hormone metabolic process
GO:0032787	1.416e-03	8.198	22 ACOT12, ACOX1, AGXT, AKR1D1, APOA4, BAAT, CYP1A1, ELOVL2, FPGS, GCK, GHR, GNMT, GPAM, GPT, HAO1, IGF1, MTHFD1, NR5A2, PFKFB1, SDS, SULT2A1, TMEM195	279	monocarboxylic acid metabolic process
GO:0010876	1.638e-03	4.349	15 ABCA4, ABCG5, APOA4, APOB, APOF, INHBA, LBP, LDLR, NPC1L1, OSBPL11, PON1, SCARB1, SIGMAR1, SOAT2, STARD5	148	lipid localization
GO:0015918	1.695e-03	1.263	8 ABCG5, APOA4, APOB, LDLR, NPC1L1, PON1, SCARB1, SOAT2	43	sterol transport
GO:0030301	1.695e-03	1.263	8 ABCG5, APOA4, APOB, LDLR, NPC1L1, PON1, SCARB1, SOAT2	43	cholesterol transport
GO:0006694	2.160e-03	2.527	11 AKR1D1, APOB, CYP17A1, HMGCS2, MVD, NPC1L1, NSDHL, SCARB1, SIGMAR1, STARD5, TM7SF2	86	steroid biosynthetic process
GO:0002682	2.271e-03	9.755	24 AMBP, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD1D, CFP, F7, FCN2, FOXP3, GPAM, HPX, IL2, INHBA, LBP, MASP2, NFAM1, SLC11A1, TLR6, VSIG4	332	regulation of immune system process
GO:0048584	2.316e-03	6.729	19 C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD1D, CFP, F7, FCN2, HPX, LBP, MASP2, NFAM1, SLC11A1, TLR6, VSIG4	229	positive regulation of response to stimulus
GO:0046685	2.428e-03	0.2351	4 AS3MT, CPOX, CYP1A1, GCLC	8	response to arsenic
GO:0016126	2.485e-03	0.999	7 APOB, HMGCS2, MVD, NPC1L1, NSDHL, SIGMAR1, TM7SF2	34	sterol biosynthetic process
GO:0044248	2.851e-03	21.74	41 ACER1, ACOX1, AGFG2, AKR1D1, AMBP, AMDHD1, APOA4, APOB, ARAP1, ARFGAP2, ARG1, CAT, CCL24, CDO1, COMT, CYP1A1, DPYD, EDEM1, ENDOG, EPHX1, FGD2, GCLC, HAO1, IGF1, IVD, LDLR, MTHFD1, NAGA, NR1I2, NT5M, PCSK9, PON1, PSMB2, RNASE6, SDS, SMPDL3A, SULT2A1, TAT, TDO2, UROC1, XDH	740	cellular catabolic process
GO:0018904	2.935e-03	1.381	8 APOA4, APOB, CAT, CDIPT, CYP1A1, GPAM, PCSK9, TMEM195	47	organic ether metabolic process
GO:0002443	3.073e-03	3.115	12 C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, FOXP3, HPX, IL2, MASP2, SLC11A1	106	leukocyte mediated immunity
GO:0010033	3.722e-03	20.57	39 ACP2, AFP, AGXT, APOB, AQP9, CDO1, COMT, CREB3L3, CYP1A1, DDOST, EDEM1, ENDOG, EPHX1, ESR1, F7, FOXA1, GCK, GCLC, GHR, GPAM, GYS2, HMGCS2, HPX, IGFBP1, IL10RA, LBP, LDLR, P2RX3, PCSK9, PEMT, PFKFB1, SCARB1, SDC2, SDS, SERPINA7, SLC11A1, TAT, TLR1, TLR6	700	response to organic substance
GO:0044255	4.013e-03	13.52	29 ACER1, ACOT12, ACOX1, ADH4, APOA4, APOB, BAAT, CAT, CDIPT, CYP1A1, ELOVL2, GHR, GNE, GPAM, GPLD1, HAO1, HMGCS2, MVD, NAGA, PCSK9, PCYT2, PEMT, PLA2G2D, PON1, RBP1, SLC35C1, SMPDL3A, SOAT2, TMEM195	460	cellular lipid metabolic process
GO:0048583	4.297e-03	12.9	28 ADRB2, AMBP, C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CD1D, CFP, CPB2, F2, F7, FCN2, FOXP3, HPX, HRG, IL2, KLKB1, LBP, MASP2, NFAM1, SERPINC1, SLC11A1, TLR6, VSIG4	439	regulation of response to stimulus
GO:0042445	4.305e-03	2.762	11 ADH4, AFP, AKR1D1, COMT, CYP17A1, CYP1A1, ESR1, FOXA1, PCSK6, SCARB1, SERPINA6	94	hormone metabolic process
GO:0019439	4.523e-03	0.4995	5 CYP1A1, EPHX1, PON1, TAT, TDO2	17	aromatic compound catabolic process
GO:0006534	4.534e-03	0.1175	3 CDO1, CTH, GCLC	4	cysteine metabolic process
GO:0006695	4.890e-03	0.7933	6 APOB, HMGCS2, MVD, NPC1L1, NSDHL, TM7SF2	27	cholesterol biosynthetic process
GO:0046483	5.641e-03	13.84	29 ADRB2, AGFG2, ALAS1, AMBP, AMDHD1, ARAP1, ARFGAP2, CCL24, CPOX, CYP1A1, DPYD, FGD2, FPGS, GHR, GUCA2B, HPX, MOCOS, MTHFD1, NADK, NT5M, PAPSS1, PKD2, PRHOXNB, PYGL, SLC19A3, TDO2, TTPA, UROC1, XDH	471	heterocycle metabolic process
GO:0019835	5.798e-03	0.5289	5 C5, C8A, C8B, C8G, C9	18	cytolysis
GO:0051917	5.830e-03	0.2938	4 CPB2, F2, HRG, KLKB1	10	regulation of fibrinolysis
GO:0030194	8.266e-03	0.3232	4 CPB2, F2, F7, HRG	11	positive regulation of blood coagulation
GO:0031667	9.320e-03	5.818	16 ABCG5, CYP1A1, F7, FOXA3, GGCX, GHR, GPAM, HMGCS2, PCSK9, PEMT, PFKFB1, SDS, SERPINA7, SERPINC1, SOAT2, TTPA	198	response to nutrient levels
GO:0016045	1.114e-02	0.3526	4 CD1D, PGLYRP2, TLR1, TLR6	12	detection of bacterium
GO:0006662	1.132e-02	1.322	7 APOA4, APOB, CAT, CDIPT, GPAM, PCSK9, TMEM195	45	glycerol ether metabolic process
GO:0010817	1.165e-02	5.377	15 ADH4, AFP, AKR1D1, COMT, CYP17A1, CYP1A1, ESR1, FOXA1, FST, GCK, INHBA, PCSK6, SCARB1, SERPINA6, SLC16A2	183	regulation of hormone levels
GO:0042592	1.391e-02	19.22	35 ABCG5, ADRB2, APOA4, APOB, AQP9, C3AR1, CCL23, CCR7, CP, CXCR3, F2, FOXA1, FOXA3, FOXP3, GCK, GCKR, GCLC, GPAM, HPX, IGF1, IL2, INHBA, LDLR, NPC1L1, NR5A2, OTC, P2RX3, PCSK9, PKD2, PYGL, SCARB1, SLC11A1, SLC9A8, SOAT2, TFR2	654	homeostatic process
GO:0006575	1.405e-02	3.79	12 APOA4, CCBL1, CDO1, COMT, CTH, CYP1A1, GCLC, GHR, GNMT, PEMT, PON1, TDO2	129	cellular amino acid derivative metabolic process
GO:0042730	1.463e-02	0.382	4 CPB2, F2, HRG, KLKB1	13	fibrinolysis
GO:0050820	1.463e-02	0.382	4 CPB2, F2, F7, HRG	13	positive regulation of coagulation
GO:0000050	1.589e-02	0.1763	3 ARG1, OTC, SLC25A15	6	urea cycle
GO:0019627	1.589e-02	0.1763	3 ARG1, OTC, SLC25A15	6	urea metabolic process
GO:0046364	1.626e-02	1.028	6 GCK, GNMT, GPT, PFKFB1, PYGL, SDS	35	monosaccharide biosynthetic process
GO:0009991	1.771e-02	6.259	16 ABCG5, CYP1A1, F7, FOXA3, GGCX, GHR, GPAM, HMGCS2, PCSK9, PEMT, PFKFB1, SDS, SERPINA7, SERPINC1, SOAT2, TTPA	213	response to extracellular stimulus
GO:0051241	1.836e-02	4.496	13 ABCG5, ADRB2, CPB2, F2, FOXP3, HRG, IL2, KLKB1, LBP, LGMN, PCSK9, SLC11A1, VSIG4	153	negative regulation of multicellular organismal process
GO:0033344	1.847e-02	0.7052	5 ABCG5, APOA4, PON1, SCARB1, SOAT2	24	cholesterol efflux
GO:0007586	1.916e-02	1.91	8 ABCG5, AKR1D1, APOA4, BAAT, LDLR, NPC1L1, SOAT2, SULT2A1	65	digestion
GO:0046700	2.024e-02	5.142	14 AGFG2, AMBP, AMDHD1, ARAP1, ARFGAP2, CCL24, CYP1A1, DPYD, FGD2, MTHFD1, NT5M, TDO2, UROC1, XDH	175	heterocycle catabolic process
GO:0006094	2.134e-02	0.7346	5 GCK, GNMT, GPT, PFKFB1, SDS	25	gluconeogenesis
GO:0008610	2.270e-02	9.05	20 AKR1D1, APOA4, APOB, CDIPT, CYP17A1, CYP1A1, ELOVL2, GNE, GPAM, HMGCS2, MVD, NPC1L1, NSDHL, PCYT2, PEMT, SCARB1, SIGMAR1, STARD5, TM7SF2, TMEM195	308	lipid biosynthetic process
GO:0006090	2.298e-02	1.117	6 AGXT, GCK, GNMT, GPT, PFKFB1, SDS	38	pyruvate metabolic process
GO:0009064	2.298e-02	1.117	6 AMDHD1, ARG1, ART4, GCLC, OTC, TAT	38	glutamine family amino acid metabolic process
GO:0020027	2.386e-02	0.2057	3 CAT, HPX, INHBA	7	hemoglobin metabolic process
GO:0030212	2.386e-02	0.2057	3 ITIH1, ITIH3, ITIH4	7	hyaluronan metabolic process
GO:0051918	2.386e-02	0.2057	3 CPB2, F2, HRG	7	negative regulation of fibrinolysis
GO:0006145	2.500e-02	0.05877	2 DPYD, XDH	2	purine base catabolic process
GO:0009441	2.500e-02	0.05877	2 HAO1, IGF1	2	glycolate metabolic process
GO:0015774	2.500e-02	0.05877	2 LBP, SCARB1	2	polysaccharide transport
GO:0015920	2.500e-02	0.05877	2 LBP, SCARB1	2	lipopolysaccharide transport
GO:0032571	2.500e-02	0.05877	2 F7, GGCX	2	response to vitamin K
GO:0034441	2.500e-02	0.05877	2 APOA4, PON1	2	plasma lipoprotein oxidation
GO:0034444	2.500e-02	0.05877	2 APOA4, PON1	2	regulation of plasma lipoprotein oxidation
GO:0034445	2.500e-02	0.05877	2 APOA4, PON1	2	negative regulation of plasma lipoprotein oxidation
GO:0042866	2.500e-02	0.05877	2 AGXT, SDS	2	pyruvate biosynthetic process
GO:0060741	2.500e-02	0.05877	2 FOXA1, IGF1	2	prostate gland stromal morphogenesis
GO:0044272	2.786e-02	1.175	6 CDO1, CTH, GCLC, HS3ST3B1, IGF1, MTHFD1	40	sulfur compound biosynthetic process
GO:0005975	2.882e-02	12.81	25 A4GNT, ALDH1B1, ALG2, ALG3, B3GNT7, DDOST, GCK, GK5, GNE, GNMT, GPT, GYS2, H6PD, IGF1, ITIH1, ITIH3, ITIH4, LDLR, NAGA, ONECUT1, PFKFB1, PGLYRP2, PYGL, SDS, SERPINA12	436	carbohydrate metabolic process
GO:0034637	2.911e-02	2.086	8 GCK, GNE, GNMT, GPT, GYS2, PFKFB1, PYGL, SDS	71	cellular carbohydrate biosynthetic process
GO:0051606	2.934e-02	3.115	10 ABCA4, CD1D, GCK, GNAT1, LBP, PGLYRP2, PKD2, SCARB1, TLR1, TLR6	106	detection of stimulus
GO:0042523	3.261e-02	0.2351	3 GHR, IGF1, IL2	8	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0050746	3.261e-02	0.2351	3 APOA4, PEMT, PON1	8	regulation of lipoprotein metabolic process
GO:0070229	3.261e-02	0.2351	3 GPAM, IL2, PTCRA	8	negative regulation of lymphocyte apoptosis
GO:0006732	3.271e-02	3.732	11 ACOT12, BAAT, CTH, FPGS, GCLC, GPAM, H6PD, MOCOS, MTHFD1, NADK, TDO2	127	coenzyme metabolic process
GO:0006639	3.363e-02	1.234	6 APOA4, APOB, CAT, CDIPT, GPAM, PCSK9	42	acylglycerol metabolic process
GO:0009593	3.536e-02	0.8521	5 GCK, LBP, SCARB1, TLR1, TLR6	29	detection of chemical stimulus
GO:0016042	3.621e-02	4.378	12 ACER1, ACOX1, AKR1D1, APOA4, APOB, HAO1, LIPM, NAGA, PLA2G2D, SCARB1, SMPDL3A, SULT2A1	149	lipid catabolic process
GO:0006638	3.691e-02	1.263	6 APOA4, APOB, CAT, CDIPT, GPAM, PCSK9	43	neutral lipid metabolic process
GO:0007260	3.961e-02	0.8815	5 F2, GHR, HPX, IGF1, IL2	30	tyrosine phosphorylation of STAT protein
GO:0008652	3.961e-02	0.8815	5 AGXT, CDO1, CTH, MTHFD1, OTC	30	cellular amino acid biosynthetic process
GO:0019319	3.961e-02	0.8815	5 GCK, GNMT, GPT, PFKFB1, SDS	30	hexose biosynthetic process
GO:0030193	3.961e-02	0.8815	5 CPB2, F2, F7, HRG, KLKB1	30	regulation of blood coagulation
GO:0009617	3.991e-02	5.054	13 CD1D, CFP, COMT, CYP1A1, HCK, IL10RA, LBP, PGLYRP2, SCARB1, SLC11A1, STAB2, TLR1, TLR6	172	response to bacterium
GO:0006935	4.096e-02	4.466	12 C3AR1, C5, CCL23, CCL24, CCR7, CXCR2, CXCR3, F7, FPR3, LBP, LECT2, SERPIND1	152	chemotaxis
GO:0042330	4.096e-02	4.466	12 C3AR1, C5, CCL23, CCL24, CCR7, CXCR2, CXCR3, F7, FPR3, LBP, LECT2, SERPIND1	152	taxis
GO:0006548	4.318e-02	0.2644	3 AMDHD1, MTHFD1, UROC1	9	histidine catabolic process
GO:0009077	4.318e-02	0.2644	3 AMDHD1, MTHFD1, UROC1	9	histidine family amino acid catabolic process
GO:0034383	4.318e-02	0.2644	3 APOB, LDLR, PCSK9	9	low-density lipoprotein particle clearance
GO:0046689	4.318e-02	0.2644	3 AQP9, CPOX, TAT	9	response to mercury ion
GO:0006006	4.488e-02	3.937	11 GCK, GNMT, GPT, GYS2, H6PD, IGF1, ONECUT1, PFKFB1, PYGL, SDS, SERPINA12	134	glucose metabolic process
GO:0008206	4.559e-02	0.5583	4 AKR1D1, BAAT, NR5A2, SULT2A1	19	bile acid metabolic process
GO:0034381	4.559e-02	0.5583	4 APOB, LDLR, PCSK9, SCARB1	19	lipoprotein particle clearance
GO:0042531	4.559e-02	0.5583	4 GHR, HPX, IGF1, IL2	19	positive regulation of tyrosine phosphorylation of STAT protein
GO:0005976	4.563e-02	2.821	9 GCK, GNE, GNMT, GYS2, ITIH1, ITIH3, ITIH4, PGLYRP2, PYGL	96	polysaccharide metabolic process
GO:0040014	4.770e-02	1.352	6 ADRB2, ATRN, GHR, GPAM, IGF1, LGMN	46	regulation of multicellular organism growth
GO:0007584	4.871e-02	3.996	11 ABCG5, CYP1A1, F7, GGCX, HMGCS2, PEMT, SDS, SERPINA7, SERPINC1, SOAT2, TTPA	136	response to nutrient
GO:0006778	4.921e-02	0.9403	5 ALAS1, AMBP, CPOX, CYP1A1, HPX	32	porphyrin metabolic process
GO:0022600	4.921e-02	0.9403	5 ABCG5, APOA4, LDLR, NPC1L1, SOAT2	32	digestive system process
GO:0033013	4.921e-02	0.9403	5 ALAS1, AMBP, CPOX, CYP1A1, HPX	32	tetrapyrrole metabolic process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005576	1.157e-11	40.24	89 ADAM12, AFP, AMBP, AOAH, APOA4, APOB, APOF, ATRN, BTD, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CCL23, CCL24, CD5L, CFP, CP, CPA6, CPB2, CREG1, DKK2, DNASE2B, F2, F7, F9, FCN2, FCRLA, FETUB, FGB, FST, GC, GDF2, GHR, GPLD1, GUCA2B, HPX, HRG, IGF1, IGFALS, IGFBP1, IL2, INHBA, INHBC, INHBE, ITIH1, ITIH3, ITIH4, KLKB1, LBP, LDLR, LECT2, LIPM, LRG1, MASP2, MCFD2, NYX, PAEP, PCSK6, PCSK9, PGLYRP2, PLA2G2D, PM20D1, PON1, PROL1, PROZ, PRSSL1, RNASE1, RNASE6, SERPINA11, SERPINA12, SERPINA4, SERPINA6, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SIGLEC1, SMPDL3A, SPP2, SRCRB4D, TECTB, TGFBI, VMO1, VWCE, XDH	1407	extracellular region
GO:0005615	2.319e-07	15.7	42 AFP, APOA4, APOB, APOF, ATRN, BTD, C5, C8A, C8B, CCL23, CCL24, CD5L, CFP, CP, CPB2, DKK2, F2, F7, FCN2, FGB, GC, GDF2, GHR, HPX, IGF1, IGFALS, IGFBP1, IL2, INHBA, KLKB1, LBP, LDLR, LECT2, PCSK6, PCSK9, PON1, SERPINA4, SERPINA6, SERPINA7, SERPINC1, SMPDL3A, TGFBI	549	extracellular space
GO:0005579	1.281e-05	0.2002	5 C5, C8A, C8B, C8G, C9	7	membrane attack complex
GO:0044421	3.359e-05	21.13	45 AFP, APOA4, APOB, APOF, ATRN, BTD, C5, C8A, C8B, CCL23, CCL24, CD5L, CFP, CP, CPB2, DKK2, F2, F7, FCN2, FGB, GC, GDF2, GHR, GPLD1, HPX, IGF1, IGFALS, IGFBP1, IL2, INHBA, KLKB1, LBP, LDLR, LECT2, NYX, PCSK6, PCSK9, PON1, SERPINA4, SERPINA6, SERPINA7, SERPINC1, SMPDL3A, TECTB, TGFBI	739	extracellular region part
GO:0000267	4.450e-04	23.59	45 A4GNT, ABCA4, ABCB11, ABCG5, ACP2, ADRB2, ALG2, AMBP, APOB, AQP9, AS3MT, COMT, CYP1A1, CYP3A43, DDOST, DSC3, ELOVL2, EPHX1, F2, F7, FGB, FMO3, GGCX, GYS2, H6PD, IGFALS, MVD, P2RX3, PCSK6, PEMT, PON1, PYGL, RDH16, SCARB1, SLC10A1, SLC16A2, SLC17A2, SLC17A4, SLC22A1, SLC26A3, SLC6A2, SLCO1B1, SOAT2, TDO2, TPST1	825	cell fraction
GO:0005626	4.753e-04	17.9	37 A4GNT, ABCA4, ABCB11, ABCG5, ACP2, ADRB2, ALG2, AMBP, APOB, AQP9, COMT, CYP1A1, CYP3A43, DDOST, DSC3, ELOVL2, EPHX1, F7, FMO3, GGCX, GYS2, H6PD, P2RX3, PEMT, PON1, RDH16, SCARB1, SLC10A1, SLC16A2, SLC17A2, SLC17A4, SLC22A1, SLC26A3, SLC6A2, SLCO1B1, SOAT2, TPST1	626	insoluble fraction
GO:0005624	4.969e-04	17.24	36 A4GNT, ABCA4, ABCB11, ABCG5, ACP2, ADRB2, ALG2, AMBP, APOB, AQP9, COMT, CYP1A1, CYP3A43, DDOST, DSC3, ELOVL2, EPHX1, F7, FMO3, GGCX, H6PD, P2RX3, PEMT, PON1, RDH16, SCARB1, SLC10A1, SLC16A2, SLC17A2, SLC17A4, SLC22A1, SLC26A3, SLC6A2, SLCO1B1, SOAT2, TPST1	603	membrane fraction
GO:0042598	5.956e-04	4.833	16 ADRB2, AMBP, APOB, AQP9, COMT, CYP1A1, CYP3A43, DDOST, ELOVL2, EPHX1, F7, FMO3, H6PD, PON1, RDH16, SOAT2	169	vesicular fraction
GO:0031226	6.448e-04	27	49 ABCA4, ABCB11, ADRB2, AQP9, ATRN, C3AR1, C5, C8A, C8B, C8G, C9, CCR7, CD1C, CD1D, CD1E, CD33, CXCR2, CXCR3, EMR1, F2RL2, GHR, HS3ST3B1, IGSF6, ITGAD, LDLR, LYPD3, MARCO, NUMB, P2RX3, PTGER2, SCARB1, SDC2, SIGMAR1, SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC22A1, SLC6A2, SLC7A6, SLCO1B1, SLCO1B3, STAB2, TFR2, TLR1, TLR6, TM7SF2, TRPM1	944	intrinsic to plasma membrane
GO:0005887	7.547e-04	26.42	48 ABCA4, ABCB11, ADRB2, AQP9, ATRN, C3AR1, C5, C8A, C8B, C8G, C9, CCR7, CD1C, CD1D, CD1E, CD33, CXCR2, CXCR3, EMR1, F2RL2, GHR, HS3ST3B1, IGSF6, ITGAD, LDLR, MARCO, NUMB, P2RX3, PTGER2, SCARB1, SDC2, SIGMAR1, SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC22A1, SLC6A2, SLC7A6, SLCO1B1, SLCO1B3, STAB2, TFR2, TLR1, TLR6, TM7SF2, TRPM1	924	integral to plasma membrane
GO:0005792	1.306e-03	4.661	15 ADRB2, AMBP, APOB, AQP9, COMT, CYP1A1, CYP3A43, DDOST, ELOVL2, EPHX1, FMO3, H6PD, PON1, RDH16, SOAT2	163	microsome
GO:0071212	1.387e-03	15.41	32 ACER1, ALG3, APOA4, APOB, CDIPT, CNIH, CREB3L3, CYP17A1, CYP1A1, CYP3A43, DDOST, EDEM1, ELOVL2, EPHX1, FMO3, GGCX, H6PD, INSIG1, NSDHL, P2RX3, PCSK9, PEMT, POR, RDH16, SEC16B, SEC22C, SEC24A, SEL1L, SIGMAR1, SOAT2, SRPR, TM7SF2	539	subsynaptic reticulum
GO:0044432	2.846e-03	14.7	30 ACER1, ALG3, APOA4, APOB, CDIPT, CNIH, CREB3L3, CYP17A1, CYP1A1, CYP3A43, DDOST, EDEM1, ELOVL2, EPHX1, FMO3, GGCX, H6PD, INSIG1, NSDHL, PEMT, POR, RDH16, SEC16B, SEC22C, SEC24A, SEL1L, SIGMAR1, SOAT2, SRPR, TM7SF2	514	endoplasmic reticulum part
GO:0005783	3.284e-03	22.16	40 A1CF, ACER1, ALG3, APOA4, APOB, CAT, CDIPT, CLDN14, CNIH, CREB3L3, CYP17A1, CYP1A1, CYP3A43, DDOST, EDEM1, ELOVL2, EPHX1, FMO3, GGCX, H6PD, INSIG1, LRG1, MCFD2, NSDHL, P2RX3, PCSK6, PCSK9, PEMT, PKD2, POR, RDH16, SEC16B, SEC22C, SEC24A, SEL1L, SIGMAR1, SOAT2, SRPR, TM7SF2, TMEM195	775	endoplasmic reticulum
GO:0032994	4.232e-03	0.6005	5 APOA4, APOB, APOF, LDLR, PON1	21	protein-lipid complex
GO:0034358	4.232e-03	0.6005	5 APOA4, APOB, APOF, LDLR, PON1	21	plasma lipoprotein particle
GO:0005789	5.685e-03	13.27	27 ACER1, ALG3, CDIPT, CNIH, CREB3L3, CYP17A1, CYP1A1, CYP3A43, DDOST, EDEM1, ELOVL2, EPHX1, FMO3, GGCX, INSIG1, NSDHL, PEMT, POR, RDH16, SEC16B, SEC22C, SEC24A, SEL1L, SIGMAR1, SOAT2, SRPR, TM7SF2	464	endoplasmic reticulum membrane
GO:0042175	8.258e-03	13.64	27 ACER1, ALG3, CDIPT, CNIH, CREB3L3, CYP17A1, CYP1A1, CYP3A43, DDOST, EDEM1, ELOVL2, EPHX1, FMO3, GGCX, INSIG1, NSDHL, PEMT, POR, RDH16, SEC16B, SEC22C, SEC24A, SEL1L, SIGMAR1, SOAT2, SRPR, TM7SF2	477	nuclear membrane-endoplasmic reticulum network
GO:0000323	1.229e-02	5.319	14 ACP2, ADRB2, CAT, CD1B, CD1D, CD1E, CXCR2, DNASE2B, LDLR, LGMN, NAAA, NAGA, PCSK9, SLC11A1	186	lytic vacuole
GO:0005764	1.229e-02	5.319	14 ACP2, ADRB2, CAT, CD1B, CD1D, CD1E, CXCR2, DNASE2B, LDLR, LGMN, NAAA, NAGA, PCSK9, SLC11A1	186	lysosome
GO:0031224	1.331e-02	106.3	133 A4GNT, ABCA4, ABCB11, ABCG5, ACER1, ACP2, ADAM12, ADRB2, ALG2, ALG3, AQP9, ART4, ATRN, B3GNT7, BOC, C11orf24, C17orf87, C1orf130, C22orf32, C3AR1, C5, C8A, C8B, C8G, C9, CCR7, CD180, CD1B, CD1C, CD1D, CD1E, CD33, CDIPT, CEACAM16, CLDN14, CNIH, COMT, CREB3L3, CXCR2, CXCR3, DDOST, DSC3, EDEM1, ELOVL2, EMR1, EPHX1, F2RL2, FAM189B, FAM26D, FMO3, FPR3, GGCX, GHR, GPAM, GPR128, GPR152, HS3ST3A1, HS3ST3B1, IGSF6, IL10RA, IL1R2, INSIG1, ITGAD, LDLR, LRRC25, LYPD3, MARCO, NFAM1, NIPAL1, NPC1L1, NSDHL, NUMB, OR10H3, P2RX3, PEMT, PKD2, PPAPDC1B, PTCRA, PTGER2, RDH16, RHBDD3, RNF149, SARM1, SCARB1, SDC2, SEC22C, SEL1L, SIGLEC1, SIGMAR1, SIRPB2, SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC19A3, SLC22A1, SLC25A15, SLC25A25, SLC26A3, SLC30A10, SLC35C1, SLC38A4, SLC39A9, SLC41A2, SLC45A3, SLC46A1, SLC46A3, SLC6A2, SLC7A6, SLC9A8, SLCO1B1, SLCO1B3, SOAT2, SRPR, STAB2, SYT8, TECTB, TFR2, TLR1, TLR6, TM4SF4, TM7SF2, TMEM154, TMEM195, TMEM199, TMEM20, TPST1, TRPM1, TRPM5, TSPAN3, UNC93A, VSIG4	3717	intrinsic to membrane
GO:0030670	1.509e-02	0.2288	3 SLC11A1, TLR1, TLR6	8	phagocytic vesicle membrane
GO:0016021	1.623e-02	104	130 A4GNT, ABCA4, ABCB11, ABCG5, ACER1, ACP2, ADAM12, ADRB2, ALG2, ALG3, AQP9, ATRN, B3GNT7, BOC, C11orf24, C17orf87, C1orf130, C22orf32, C3AR1, C5, C8A, C8B, C8G, C9, CCR7, CD180, CD1B, CD1C, CD1D, CD1E, CD33, CDIPT, CEACAM16, CLDN14, CNIH, COMT, CREB3L3, CXCR2, CXCR3, DDOST, DSC3, EDEM1, ELOVL2, EMR1, EPHX1, F2RL2, FAM189B, FAM26D, FMO3, FPR3, GGCX, GHR, GPAM, GPR128, GPR152, HS3ST3A1, HS3ST3B1, IGSF6, IL10RA, IL1R2, INSIG1, ITGAD, LDLR, LRRC25, LYPD3, MARCO, NFAM1, NIPAL1, NPC1L1, NSDHL, NUMB, OR10H3, P2RX3, PEMT, PKD2, PPAPDC1B, PTCRA, PTGER2, RDH16, RHBDD3, RNF149, SCARB1, SDC2, SEC22C, SEL1L, SIGLEC1, SIGMAR1, SIRPB2, SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC19A3, SLC22A1, SLC25A15, SLC25A25, SLC26A3, SLC30A10, SLC35C1, SLC38A4, SLC39A9, SLC41A2, SLC45A3, SLC46A1, SLC46A3, SLC6A2, SLC7A6, SLC9A8, SLCO1B1, SLCO1B3, SOAT2, SRPR, STAB2, SYT8, TFR2, TLR1, TLR6, TM4SF4, TM7SF2, TMEM154, TMEM195, TMEM199, TMEM20, TPST1, TRPM1, TRPM5, TSPAN3, UNC93A, VSIG4	3638	integral to membrane
GO:0044425	1.835e-02	122.6	149 A4GNT, ABCA4, ABCB11, ABCG5, ACER1, ACP2, ADAM12, ADRB2, ALG2, ALG3, AP3M2, AQP9, ART4, ATRN, B3GNT7, BOC, C11orf24, C17orf87, C1orf130, C20orf7, C22orf32, C3AR1, C5, C8A, C8B, C8G, C9, CCR7, CD180, CD1B, CD1C, CD1D, CD1E, CD33, CDC42BPA, CDIPT, CEACAM16, CLDN14, CNIH, COMT, CREB3L3, CXCR2, CXCR3, CYP17A1, CYP1A1, CYP3A43, DDOST, DSC3, EDEM1, ELOVL2, EMR1, EPHX1, ESR1, F2RL2, FAM189B, FAM26D, FGB, FGD2, FMO3, FPR3, GGCX, GHR, GPAM, GPR128, GPR152, HCK, HS3ST3A1, HS3ST3B1, IGSF6, IL10RA, IL1R2, INSIG1, ITGAD, LDLR, LRRC25, LYPD3, MARCO, NFAM1, NIPAL1, NPC1L1, NSDHL, NUMB, OR10H3, P2RX3, PARVG, PCSK9, PEMT, PKD2, POR, PPAPDC1B, PTCRA, PTGER2, RDH16, RHBDD3, RNF149, SARM1, SCARB1, SDC2, SEC16B, SEC22C, SEC24A, SEL1L, SIGLEC1, SIGMAR1, SIRPB2, SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC19A3, SLC22A1, SLC25A15, SLC25A25, SLC26A3, SLC30A10, SLC35C1, SLC38A4, SLC39A9, SLC41A2, SLC45A3, SLC46A1, SLC46A3, SLC6A2, SLC7A6, SLC9A8, SLCO1B1, SLCO1B3, SNTB1, SOAT2, SRPR, STAB2, SYT8, TECTB, TFR2, TLR1, TLR6, TM4SF4, TM7SF2, TMEM154, TMEM195, TMEM199, TMEM20, TPST1, TRPM1, TRPM5, TSPAN3, UNC93A, VSIG4	4287	membrane part
GO:0005886	2.119e-02	75.04	98 ABCA4, ABCB11, ABCG5, ADAM12, ADRB2, AMBP, APOB, AQP9, ARAP1, ARFGAP2, ART4, ATRN, BOC, C3AR1, C5, C8A, C8B, C8G, C9, CAT, CCR7, CD180, CD1B, CD1C, CD1D, CD1E, CD33, CDC42BPA, CDIPT, CLDN14, COMT, CXCR2, CXCR3, DSC3, EMR1, ESR1, F2, F2RL2, F7, F9, FGB, FGD2, FPR3, GHR, GNAT1, GPR128, GPR152, HCK, HS3ST3B1, IGSF6, IL10RA, ITGAD, LDLR, LYPD3, MARCO, NFAM1, NPC1L1, NUMB, OR10H3, P2RX3, PARVG, PCSK9, PEMT, PKD2, PTGER2, RAPH1, RGS13, SCARB1, SDC2, SERPINC1, SIGLEC1, SIGMAR1, SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC22A1, SLC26A3, SLC30A10, SLC38A4, SLC41A2, SLC46A1, SLC6A2, SLC7A6, SLCO1B1, SLCO1B3, SNTB1, STAB2, SYT8, TECTB, TFR2, TLR1, TLR6, TM7SF2, TRPM1, TRPM5, UNC93A	2624	plasma membrane
GO:0005777	2.199e-02	2.259	8 ACOX1, AGXT, BAAT, CAT, HAO1, MVD, PRHOXNB, XDH	79	peroxisome
GO:0042579	2.199e-02	2.259	8 ACOX1, AGXT, BAAT, CAT, HAO1, MVD, PRHOXNB, XDH	79	microbody
GO:0030666	2.347e-02	0.9151	5 APOB, LDLR, SLC11A1, TLR1, TLR6	32	endocytic vesicle membrane
GO:0034362	2.744e-02	0.286	3 APOB, APOF, LDLR	10	low-density lipoprotein particle
GO:0044459	2.923e-02	45.53	64 ABCA4, ABCB11, ABCG5, ADRB2, AQP9, ATRN, C3AR1, C5, C8A, C8B, C8G, C9, CCR7, CD1C, CD1D, CD1E, CD33, CDC42BPA, CLDN14, CXCR2, CXCR3, DSC3, EMR1, ESR1, F2RL2, FGB, FGD2, GHR, HCK, HS3ST3B1, IGSF6, ITGAD, LDLR, LYPD3, MARCO, NPC1L1, NUMB, P2RX3, PARVG, PCSK9, PEMT, PTGER2, SCARB1, SDC2, SIGMAR1, SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC22A1, SLC26A3, SLC46A1, SLC6A2, SLC7A6, SLCO1B1, SLCO1B3, SNTB1, STAB2, TFR2, TLR1, TLR6, TM7SF2, TRPM1	1592	plasma membrane part
GO:0045335	3.501e-02	0.3146	3 SLC11A1, TLR1, TLR6	11	phagocytic vesicle
GO:0016020	4.493e-02	147.2	171 A4GNT, ABCA4, ABCB11, ABCG5, ACER1, ACOX1, ACP2, ADAM12, ADRB2, ALG2, ALG3, AMBP, AP3M2, APOB, AQP9, ARAP1, ARFGAP2, ART4, ATRN, B3GNT7, BOC, C11orf24, C17orf87, C1orf130, C20orf7, C22orf32, C3AR1, C5, C8A, C8B, C8G, C9, CAT, CCR7, CD180, CD1B, CD1C, CD1D, CD1E, CD33, CD5L, CDC42BPA, CDIPT, CEACAM16, CLDN14, CNIH, COMT, CREB3L3, CXCR2, CXCR3, CYP17A1, CYP1A1, CYP3A43, DDOST, DNAJA4, DSC3, EDEM1, ELOVL2, EMR1, EPHX1, ESR1, F2, F2RL2, F7, F9, FAM189B, FAM26D, FGB, FGD2, FMO3, FPR3, GGCX, GHR, GNAT1, GPAM, GPR128, GPR152, HCK, HMGCS2, HS3ST3A1, HS3ST3B1, IGSF6, IL10RA, IL1R2, INSIG1, ITGAD, IVD, LDLR, LRG1, LRRC25, LYPD3, MARCO, NFAM1, NIPAL1, NPC1L1, NSDHL, NUMB, OR10H3, OTC, P2RX3, PARVG, PCSK6, PCSK9, PEMT, PGLYRP2, PKD2, POR, PPAPDC1B, PTCRA, PTGER2, RAPH1, RDH16, RGS13, RHBDD3, RNF149, SARM1, SCARB1, SDC2, SEC16B, SEC22C, SEC24A, SEL1L, SERPINC1, SIGLEC1, SIGMAR1, SIRPB2, SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC19A3, SLC22A1, SLC25A15, SLC25A25, SLC26A3, SLC30A10, SLC35C1, SLC38A4, SLC39A9, SLC41A2, SLC45A3, SLC46A1, SLC46A3, SLC6A2, SLC7A6, SLC9A8, SLCO1B1, SLCO1B3, SNTB1, SOAT2, SRCRB4D, SRPR, STAB2, SYT8, TECTB, TFR2, TLR1, TLR6, TM4SF4, TM7SF2, TMEM154, TMEM195, TMEM199, TMEM20, TPST1, TRPM1, TRPM5, TSPAN3, UNC93A, VSIG4	5148	membrane
GO:0031090	4.639e-02	40.55	57 A4GNT, ACER1, ACOX1, ACP2, ALG3, APOB, ARAP1, ARFGAP2, B3GNT7, C20orf7, CAT, CD1B, CD1C, CD1D, CD1E, CDIPT, CNIH, CREB3L3, CYP17A1, CYP1A1, CYP3A43, DDOST, EDEM1, ELOVL2, EPHX1, FGD2, FMO3, GGCX, GPAM, HMGCS2, HS3ST3A1, HS3ST3B1, INSIG1, IVD, LDLR, NPC1L1, NSDHL, OTC, PEMT, POR, RDH16, SEC16B, SEC22C, SEC24A, SEL1L, SIGMAR1, SLC11A1, SLC25A15, SLC25A25, SLC35C1, SLC9A8, SOAT2, SRPR, TLR1, TLR6, TM7SF2, TPST1	1418	organelle membrane
GO:0005773	4.742e-02	6.348	14 ACP2, ADRB2, CAT, CD1B, CD1D, CD1E, CXCR2, DNASE2B, LDLR, LGMN, NAAA, NAGA, PCSK9, SLC11A1	222	vacuole

Id	Pvalue	ExpCount	Count	Size	Term
GO:0019842	1.379e-08	2.962	19 ADH4, AGXT, ALAS1, C8G, CCBL1, CTH, GC, GCAT, GNMT, GPT, MOCOS, MUT, PYGL, RBP1, SDS, SLC19A3, SLC46A1, TAT, TTPA	107	vitamin binding
GO:0004866	3.299e-07	2.852	17 AMBP, C5, FETUB, HRG, ITIH1, ITIH3, ITIH4, PROL1, SERPINA11, SERPINA12, SERPINA4, SERPINA6, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SPP2	103	endopeptidase inhibitor activity
GO:0061135	5.061e-07	2.935	17 AMBP, C5, FETUB, HRG, ITIH1, ITIH3, ITIH4, PROL1, SERPINA11, SERPINA12, SERPINA4, SERPINA6, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SPP2	106	endopeptidase regulator activity
GO:0030414	6.617e-07	2.99	17 AMBP, C5, FETUB, HRG, ITIH1, ITIH3, ITIH4, PROL1, SERPINA11, SERPINA12, SERPINA4, SERPINA6, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SPP2	108	peptidase inhibitor activity
GO:0048037	2.949e-06	5.51	22 ACOX1, ADH4, AGXT, ALAS1, CAT, CCBL1, CTH, DPYD, FMO3, GCAT, GCLC, GPT, H6PD, HAO1, IVD, MOCOS, POR, PYGL, SDS, SOAT2, TAT, XDH	199	cofactor binding
GO:0004867	5.392e-06	1.966	13 AMBP, HRG, ITIH1, ITIH3, ITIH4, SERPINA11, SERPINA12, SERPINA4, SERPINA6, SERPINA7, SERPINA9, SERPINC1, SERPIND1	71	serine-type endopeptidase inhibitor activity
GO:0061134	9.750e-06	3.627	17 AMBP, C5, FETUB, HRG, ITIH1, ITIH3, ITIH4, PROL1, SERPINA11, SERPINA12, SERPINA4, SERPINA6, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SPP2	131	peptidase regulator activity
GO:0030170	1.579e-05	1.191	10 AGXT, ALAS1, CCBL1, CTH, GCAT, GPT, MOCOS, PYGL, SDS, TAT	43	pyridoxal phosphate binding
GO:0070279	1.579e-05	1.191	10 AGXT, ALAS1, CCBL1, CTH, GCAT, GPT, MOCOS, PYGL, SDS, TAT	43	vitamin B6 binding
GO:0008289	6.258e-05	8.887	26 ADH4, AKR1D1, APOA4, APOB, APOF, ARAP1, C8G, CD1D, CDIPT, ESR1, GC, IL2, LBP, NR5A2, OTC, PEMT, PFN2, PON1, PYGL, RBP1, SCARB1, SEC14L3, SEC14L4, SERPINA6, SOAT2, STARD5	321	lipid binding
GO:0016597	2.233e-04	1.274	9 AGXT, FMO3, GCLC, GNMT, OTC, SLC19A3, SLC46A1, TAT, TDO2	46	amino acid binding
GO:0004857	2.632e-04	5.205	18 AMBP, C5, FETUB, GCKR, HRG, ITIH1, ITIH3, ITIH4, PROL1, SERPINA11, SERPINA12, SERPINA4, SERPINA6, SERPINA7, SERPINA9, SERPINC1, SERPIND1, SPP2	188	enzyme inhibitor activity
GO:0043176	1.312e-03	2.436	11 ADRB2, AGXT, APOA4, FMO3, GCLC, GNMT, OTC, SLC19A3, SLC46A1, TAT, TDO2	88	amine binding
GO:0016769	2.491e-03	0.7198	6 AGXT, ALAS1, CCBL1, GCAT, GPT, TAT	26	transferase activity, transferring nitrogenous groups
GO:0046983	2.856e-03	12.71	28 ABCG5, ADRB2, AGXT, ALG2, AMBP, APOA4, APOB, CAT, CCBL1, CPOX, CREB3L3, CRYBA2, DPYD, FOXP3, GCLC, GHR, GYS2, INHBA, MVD, NAGA, PON1, PYGL, RRAGD, SDS, SLC11A1, TLR1, TLR6, XDH	459	protein dimerization activity
GO:0016847	6.605e-03	0.1384	3 CCBL1, GPT, TAT	5	1-aminocyclopropane-1-carboxylate synthase activity
GO:0031406	6.802e-03	3.018	11 AGXT, FMO3, GCLC, GNMT, OTC, PYGL, SLC19A3, SLC46A1, SOAT2, TAT, TDO2	109	carboxylic acid binding
GO:0016846	7.609e-03	0.3322	4 CCBL1, CTH, GPT, TAT	12	carbon-sulfur lyase activity
GO:0005496	9.655e-03	1.329	7 AKR1D1, APOF, ESR1, GC, PYGL, SERPINA6, SOAT2	48	steroid binding
GO:0015125	1.141e-02	0.1661	3 ABCB11, SLC10A1, SLCO1B3	6	bile acid transmembrane transporter activity
GO:0008028	1.299e-02	0.3876	4 ABCB11, SLC10A1, SLC16A2, SLCO1B3	14	monocarboxylic acid transmembrane transporter activity
GO:0042803	1.499e-02	8.167	19 ADRB2, AGXT, AMBP, APOA4, CAT, CCBL1, CPOX, CRYBA2, DPYD, FOXP3, GHR, GYS2, MVD, NAGA, PON1, PYGL, SDS, SLC11A1, XDH	295	protein homodimerization activity
GO:0050662	1.535e-02	3.931	12 ACOX1, ADH4, CAT, DPYD, FMO3, GCLC, H6PD, HAO1, IVD, POR, SOAT2, XDH	142	coenzyme binding
GO:0030246	1.566e-02	7.558	18 AIM1L, APOB, ATRN, CCL23, CD33, CDIPT, FCN2, GCK, HRG, IL2, PCSK6, PFKFB1, PGLYRP2, PYGL, SERPINC1, SERPIND1, SIGLEC1, STAB2	273	carbohydrate binding
GO:0004252	1.682e-02	2.907	10 F2, F7, F9, KLKB1, MASP2, PCSK6, PCSK9, PROZ, PRSSL1, RHBDD3	105	serine-type endopeptidase activity
GO:0016627	1.687e-02	1.08	6 ACOX1, AKR1D1, CPOX, DPYD, IVD, TM7SF2	39	oxidoreductase activity, acting on the CH-CH group of donors
GO:0046943	1.734e-02	1.938	8 ABCB11, AQP9, SLC10A1, SLC16A2, SLC25A15, SLC38A4, SLC7A6, SLCO1B3	70	carboxylic acid transmembrane transporter activity
GO:0005342	1.858e-02	1.966	8 ABCB11, AQP9, SLC10A1, SLC16A2, SLC25A15, SLC38A4, SLC7A6, SLCO1B3	71	organic acid transmembrane transporter activity
GO:0033872	1.914e-02	0.05537	2 HS3ST3A1, HS3ST3B1	2	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity
GO:0005506	1.952e-02	3.516	11 AMBP, CAT, CDO1, CYP17A1, CYP1A1, CYP3A43, HEBP1, POR, TDO2, TMEM195, XDH	127	iron ion binding
GO:0046906	2.306e-02	2.049	8 AMBP, CAT, CYP17A1, CYP1A1, CYP3A43, HEBP1, MUT, TDO2	74	tetrapyrrole binding
GO:0008483	2.416e-02	0.4707	4 AGXT, CCBL1, GPT, TAT	17	transaminase activity
GO:0016634	2.464e-02	0.2215	3 ACOX1, CPOX, DPYD	8	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
GO:0004872	2.574e-02	27.46	44 ADRB2, ATRN, C3AR1, CCR7, CD180, CD1D, CD33, CD5L, CXCR2, CXCR3, EMR1, ESR1, F2, F2RL2, FPR3, GHR, GPR128, GPR152, IGSF6, IL10RA, IL1R2, ITGAD, LDLR, MARCO, NFAM1, NPC1L1, NR1I2, NR5A2, OR10H3, P2RX3, PGLYRP2, PTCRA, PTGER2, SARM1, SCARB1, SIGMAR1, SRCRB4D, SRPR, STAB2, TFR2, TLR1, TLR6, TRPM1, TRPM5	992	receptor activity
GO:0005215	2.856e-02	25.25	41 ABCA4, ABCB11, ABCG5, AMBP, APOA4, APOB, APOF, AQP9, C8G, CDIPT, GC, HPX, P2RX3, PAEP, PKD2, RBP1, SCARB1, SEC14L3, SEC14L4, SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC19A3, SLC22A1, SLC25A15, SLC26A3, SLC30A10, SLC38A4, SLC39A9, SLC41A2, SLC46A1, SLC6A2, SLC7A6, SLC9A8, SLCO1B1, SLCO1B3, TRPM1, TRPM5, TTPA	912	transporter activity
GO:0017127	3.257e-02	0.2492	3 ABCG5, APOA4, APOB	9	cholesterol transporter activity
GO:0005319	3.289e-02	1.274	6 ABCA4, ABCG5, APOA4, APOB, APOF, CDIPT	46	lipid transporter activity
GO:0015291	3.361e-02	4.43	12 SLC10A1, SLC11A1, SLC16A2, SLC17A2, SLC17A4, SLC19A3, SLC26A3, SLC38A4, SLC6A2, SLC7A6, SLC9A8, SLCO1B1	160	secondary active transmembrane transporter activity
GO:0043498	3.492e-02	0.886	5 APOA4, FGB, LBP, PCSK6, STAB2	32	cell surface binding
GO:0008236	3.626e-02	3.322	10 F2, F7, F9, KLKB1, MASP2, PCSK6, PCSK9, PROZ, PRSSL1, RHBDD3	120	serine-type peptidase activity
GO:0016491	3.942e-02	13.4	25 ACOX1, ADH4, AKR1D1, ALDH1B1, CAT, CDO1, CP, CPOX, CYP17A1, CYP1A1, CYP3A43, DPYD, FMO3, H6PD, HAO1, IVD, MTHFD1, NSDHL, POR, RDH16, STAB2, TDO2, TM7SF2, TMEM195, XDH	484	oxidoreductase activity
GO:0016829	3.993e-02	3.378	10 CCBL1, CTH, GGCX, GPT, MOCOS, MVD, PRHOXNB, SDS, TAT, UROC1	122	lyase activity
GO:0017171	3.993e-02	3.378	10 F2, F7, F9, KLKB1, MASP2, PCSK6, PCSK9, PROZ, PRSSL1, RHBDD3	122	serine hydrolase activity
GO:0005542	4.214e-02	0.2769	3 GNMT, SLC19A3, SLC46A1	10	folic acid binding
GO:0030228	4.214e-02	0.2769	3 LDLR, SCARB1, STAB2	10	lipoprotein receptor activity
GO:0020037	4.302e-02	1.827	7 AMBP, CAT, CYP17A1, CYP1A1, CYP3A43, HEBP1, TDO2	66	heme binding
GO:0000033	4.315e-02	0.08306	2 ALG2, ALG3	3	alpha-1,3-mannosyltransferase activity
GO:0015232	4.315e-02	0.08306	2 HPX, SLC46A1	3	heme transporter activity
GO:0051636	4.315e-02	0.08306	2 LBP, STAB2	3	Gram-negative bacterial cell surface binding
GO:0003824	4.481e-02	108	132 A1CF, A4GNT, ABCA4, ABCB11, ABCG5, ACER1, ACOT12, ACOX1, ACP2, ADAM12, ADH4, AGXT, AKR1D1, ALAS1, ALDH1B1, ALG2, ALG3, AMDHD1, AOAH, ARG1, ART4, AS3MT, B3GNT7, BAAT, BTD, C20orf7, C3AR1, CAT, CCBL1, CDC42BPA, CDIPT, CDO1, COMT, CP, CPA6, CPB2, CPOX, CTH, CYP17A1, CYP1A1, CYP3A43, DDOST, DNASE2B, DPYD, DUSP10, EDEM1, ELOVL2, ENDOG, EPHX1, F2, F2RL2, F7, F9, FMO3, FPGS, GCAT, GCK, GCLC, GGCX, GK5, GLYATL3, GNAT1, GNE, GNMT, GPAM, GPLD1, GPT, GYS2, H6PD, HAO1, HCK, HMGCS2, HS3ST3A1, HS3ST3B1, IVD, KLKB1, LGMN, LIPM, MASP2, MAT1A, MOCOS, MTHFD1, MUT, MVD, NAAA, NADK, NAGA, NSDHL, NT5M, OTC, PAPSS1, PARP15, PCSK6, PCSK9, PCYT2, PEMT, PFKFB1, PGLYRP2, PLA2G2D, PM20D1, PON1, POR, PPAPDC1B, PRHOXNB, PROZ, PRSSL1, PSKH2, PSMB2, PYGL, RDH16, RHBDD3, RNASE1, RNASE6, RNF149, RPP40, RPS6KA2, SDS, SIGMAR1, SMPDL3A, SOAT2, SRPR, STAB2, SULT2A1, TAT, TDO2, TFR2, TM7SF2, TMEM195, TPST1, TRIM68, UROC1, XDH	3901	catalytic activity

Id	Pvalue	ExpCount	Count	Size	Term
04610	5.144e-10	2.046	17 C3AR1, C4BPA, C4BPB, C5, C8A, C8B, C8G, C9, CPB2, F2, F7, F9, FGB, KLKB1, MASP2, SERPINC1, SERPIND1	50	Complement and coagulation cascades
01100	1.628e-03	32.95	54 ACER1, ACOX1, ADH4, AGXT, AKR1D1, ALAS1, ALDH1B1, ALG2, ALG3, AMDHD1, ARG1, BAAT, BTD, CAT, CDIPT, CDO1, COMT, CPOX, CTH, CYP17A1, CYP3A43, DDOST, DPYD, FPGS, GCK, GCLC, GNE, GPAM, GPT, H6PD, HAO1, HMGCS2, IVD, MAT1A, MTHFD1, MUT, MVD, NADK, NSDHL, NT5M, OTC, PAPSS1, PCYT2, PEMT, PLA2G2D, PON1, PRHOXNB, RDH16, SDS, TAT, TDO2, TM7SF2, UROC1, XDH	805	Metabolic pathways
00260	7.777e-03	0.9823	6 AGXT, ALAS1, CTH, GCAT, GNMT, SDS	24	Glycine, serine and threonine metabolism
00140	2.980e-02	0.9004	5 AKR1D1, COMT, CYP17A1, CYP1A1, CYP3A43	22	Steroid hormone biosynthesis
00270	3.528e-02	0.9413	5 CDO1, CTH, MAT1A, SDS, TAT	23	Cysteine and methionine metabolism
05020	4.187e-02	0.9823	5 C5, C8A, C8B, C8G, C9	24	Prion diseases
04950	4.406e-02	0.6139	4 FOXA3, GCK, NR5A2, ONECUT1	15	Maturity onset diabetes of the young

No enriched terms

No enriched terms

Entrez genes

A1CFAPOBEC1 complementation factor (ENSG00000148584), score: 0.5 A4GNTalpha-1,4-N-acetylglucosaminyltransferase (ENSG00000118017), score: 0.74 ABCA4ATP-binding cassette, sub-family A (ABC1), member 4 (ENSG00000198691), score: 0.61 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.5 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.57 ACER1alkaline ceramidase 1 (ENSG00000167769), score: 0.58 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.55 ACOX1acyl-CoA oxidase 1, palmitoyl (ENSG00000161533), score: 0.55 ACP2acid phosphatase 2, lysosomal (ENSG00000134575), score: 0.57 ADAM12ADAM metallopeptidase domain 12 (ENSG00000148848), score: 0.73 ADH4alcohol dehydrogenase 4 (class II), pi polypeptide (ENSG00000198099), score: 0.54 ADRB2adrenergic, beta-2-, receptor, surface (ENSG00000169252), score: 0.53 AFPalpha-fetoprotein (ENSG00000081051), score: 0.76 AGFG2ArfGAP with FG repeats 2 (ENSG00000106351), score: 0.5 AGXTalanine-glyoxylate aminotransferase (ENSG00000172482), score: 0.55 AIM1Labsent in melanoma 1-like (ENSG00000176092), score: 0.7 AIM2absent in melanoma 2 (ENSG00000163568), score: 0.54 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.59 ALAS1aminolevulinate, delta-, synthase 1 (ENSG00000023330), score: 0.6 ALDH1B1aldehyde dehydrogenase 1 family, member B1 (ENSG00000137124), score: 0.5 ALG2asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) (ENSG00000119523), score: 0.6 ALG3asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae) (ENSG00000214160), score: 0.5 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.5 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.52 ANKRD34Bankyrin repeat domain 34B (ENSG00000189127), score: 0.49 AOAHacyloxyacyl hydrolase (neutrophil) (ENSG00000136250), score: 0.53 AP3M2adaptor-related protein complex 3, mu 2 subunit (ENSG00000070718), score: -0.5 APOA4apolipoprotein A-IV (ENSG00000110244), score: 0.75 APOBapolipoprotein B (including Ag(x) antigen) (ENSG00000084674), score: 0.53 APOFapolipoprotein F (ENSG00000175336), score: 0.57 AQP9aquaporin 9 (ENSG00000103569), score: 0.52 ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (ENSG00000186635), score: 0.5 ARFGAP2ADP-ribosylation factor GTPase activating protein 2 (ENSG00000149182), score: 0.52 ARG1arginase, liver (ENSG00000118520), score: 0.59 ARL2BPADP-ribosylation factor-like 2 binding protein (ENSG00000102931), score: -0.52 ART4ADP-ribosyltransferase 4 (Dombrock blood group) (ENSG00000111339), score: 0.63 AS3MTarsenic (+3 oxidation state) methyltransferase (ENSG00000214435), score: 0.51 ATRNattractin (ENSG00000088812), score: 0.57 B3GNT7UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (ENSG00000156966), score: 0.7 BAATbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) (ENSG00000136881), score: 0.51 BOCBoc homolog (mouse) (ENSG00000144857), score: -0.53 BTDbiotinidase (ENSG00000169814), score: 0.49 C11orf24chromosome 11 open reading frame 24 (ENSG00000171067), score: 0.56 C14orf21chromosome 14 open reading frame 21 (ENSG00000196943), score: 0.49 C17orf87chromosome 17 open reading frame 87 (ENSG00000161929), score: 0.76 C1orf130chromosome 1 open reading frame 130 (ENSG00000184454), score: 0.68 C20orf194chromosome 20 open reading frame 194 (ENSG00000088854), score: -0.52 C20orf7chromosome 20 open reading frame 7 (ENSG00000101247), score: -0.54 C22orf32chromosome 22 open reading frame 32 (ENSG00000183172), score: 0.59 C2orf54chromosome 2 open reading frame 54 (ENSG00000172478), score: 0.56 C3AR1complement component 3a receptor 1 (ENSG00000171860), score: 0.49 C4BPAcomplement component 4 binding protein, alpha (ENSG00000123838), score: 0.55 C4BPBcomplement component 4 binding protein, beta (ENSG00000123843), score: 0.5 C5complement component 5 (ENSG00000106804), score: 0.53 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.55 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.55 C8Gcomplement component 8, gamma polypeptide (ENSG00000176919), score: 0.5 C9complement component 9 (ENSG00000113600), score: 0.58 C9orf152chromosome 9 open reading frame 152 (ENSG00000188959), score: 0.91 CAMTA1calmodulin binding transcription activator 1 (ENSG00000171735), score: -0.54 CATcatalase (ENSG00000121691), score: 0.5 CCBL1cysteine conjugate-beta lyase, cytoplasmic (ENSG00000171097), score: 0.51 CCL23chemokine (C-C motif) ligand 23 (ENSG00000167236), score: 0.54 CCL24chemokine (C-C motif) ligand 24 (ENSG00000106178), score: 0.62 CCR7chemokine (C-C motif) receptor 7 (ENSG00000126353), score: 0.51 CD180CD180 molecule (ENSG00000134061), score: 0.64 CD1BCD1b molecule (ENSG00000158485), score: 0.54 CD1CCD1c molecule (ENSG00000158481), score: 0.52 CD1DCD1d molecule (ENSG00000158473), score: 0.49 CD1ECD1e molecule (ENSG00000158488), score: 0.62 CD33CD33 molecule (ENSG00000105383), score: 0.72 CD5LCD5 molecule-like (ENSG00000073754), score: 0.64 CDC42BPACDC42 binding protein kinase alpha (DMPK-like) (ENSG00000143776), score: -0.62 CDIPTCDP-diacylglycerol--inositol 3-phosphatidyltransferase (ENSG00000103502), score: 0.5 CDO1cysteine dioxygenase, type I (ENSG00000129596), score: 0.53 CDX2caudal type homeobox 2 (ENSG00000165556), score: 0.68 CEACAM16carcinoembryonic antigen-related cell adhesion molecule 16 (ENSG00000213892), score: 0.63 CFPcomplement factor properdin (ENSG00000126759), score: 0.65 CIDEBcell death-inducing DFFA-like effector b (ENSG00000136305), score: 0.58 CLDN14claudin 14 (ENSG00000159261), score: 0.6 CNIHcornichon homolog (Drosophila) (ENSG00000100528), score: 0.52 COMTcatechol-O-methyltransferase (ENSG00000093010), score: 0.49 CPceruloplasmin (ferroxidase) (ENSG00000047457), score: 0.52 CPA6carboxypeptidase A6 (ENSG00000165078), score: 0.62 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.5 CPOXcoproporphyrinogen oxidase (ENSG00000080819), score: 0.51 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.57 CREG1cellular repressor of E1A-stimulated genes 1 (ENSG00000143162), score: 0.5 CRYBA2crystallin, beta A2 (ENSG00000163499), score: 0.72 CTHcystathionase (cystathionine gamma-lyase) (ENSG00000116761), score: 0.52 CXCR2chemokine (C-X-C motif) receptor 2 (ENSG00000180871), score: 0.75 CXCR3chemokine (C-X-C motif) receptor 3 (ENSG00000186810), score: 0.56 CYP17A1cytochrome P450, family 17, subfamily A, polypeptide 1 (ENSG00000148795), score: 0.56 CYP1A1cytochrome P450, family 1, subfamily A, polypeptide 1 (ENSG00000140465), score: 0.65 CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 43 (ENSG00000021461), score: 0.73 DDOSTdolichyl-diphosphooligosaccharide--protein glycosyltransferase (ENSG00000244038), score: 0.51 DKK2dickkopf homolog 2 (Xenopus laevis) (ENSG00000155011), score: 0.74 DNAJA4DnaJ (Hsp40) homolog, subfamily A, member 4 (ENSG00000140403), score: -0.51 DNASE2Bdeoxyribonuclease II beta (ENSG00000137976), score: 0.54 DPYDdihydropyrimidine dehydrogenase (ENSG00000188641), score: 0.57 DSC3desmocollin 3 (ENSG00000134762), score: 0.88 DUSP10dual specificity phosphatase 10 (ENSG00000143507), score: 0.56 EDEM1ER degradation enhancer, mannosidase alpha-like 1 (ENSG00000134109), score: 0.54 ELOVL2elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (ENSG00000197977), score: 0.5 EMR1egf-like module containing, mucin-like, hormone receptor-like 1 (ENSG00000174837), score: 0.82 ENDOGendonuclease G (ENSG00000167136), score: 0.53 EPHX1epoxide hydrolase 1, microsomal (xenobiotic) (ENSG00000143819), score: 0.53 ESPNLespin-like (ENSG00000144488), score: 0.54 ESR1estrogen receptor 1 (ENSG00000091831), score: 0.52 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.54 F2RL2coagulation factor II (thrombin) receptor-like 2 (ENSG00000164220), score: 0.68 F7coagulation factor VII (serum prothrombin conversion accelerator) (ENSG00000057593), score: 0.55 F9coagulation factor IX (ENSG00000101981), score: 0.51 FAM189Bfamily with sequence similarity 189, member B (ENSG00000160767), score: -0.59 FAM26Dfamily with sequence similarity 26, member D (ENSG00000164451), score: 0.5 FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) (ENSG00000160339), score: 0.52 FCRLAFc receptor-like A (ENSG00000132185), score: 0.58 FETUBfetuin B (ENSG00000090512), score: 0.64 FGBfibrinogen beta chain (ENSG00000171564), score: 0.49 FGD2FYVE, RhoGEF and PH domain containing 2 (ENSG00000146192), score: 0.69 FMO3flavin containing monooxygenase 3 (ENSG00000007933), score: 0.52 FOXA1forkhead box A1 (ENSG00000129514), score: 0.6 FOXA3forkhead box A3 (ENSG00000170608), score: 0.5 FOXB2forkhead box B2 (ENSG00000204612), score: 0.55 FOXP1forkhead box P1 (ENSG00000114861), score: 0.5 FOXP3forkhead box P3 (ENSG00000049768), score: 0.7 FPGSfolylpolyglutamate synthase (ENSG00000136877), score: 0.64 FPR3formyl peptide receptor 3 (ENSG00000187474), score: 0.73 FSTfollistatin (ENSG00000134363), score: 0.6 GCgroup-specific component (vitamin D binding protein) (ENSG00000145321), score: 0.52 GCATglycine C-acetyltransferase (ENSG00000100116), score: 0.52 GCKglucokinase (hexokinase 4) (ENSG00000106633), score: 0.62 GCKRglucokinase (hexokinase 4) regulator (ENSG00000084734), score: 0.53 GCLCglutamate-cysteine ligase, catalytic subunit (ENSG00000001084), score: 0.62 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.57 GGCXgamma-glutamyl carboxylase (ENSG00000115486), score: 0.51 GHRgrowth hormone receptor (ENSG00000112964), score: 0.5 GK5glycerol kinase 5 (putative) (ENSG00000175066), score: 0.51 GLYATL3glycine-N-acyltransferase-like 3 (ENSG00000203972), score: 0.82 GNAT1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 (ENSG00000114349), score: 0.73 GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (ENSG00000159921), score: 0.52 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.6 GPAMglycerol-3-phosphate acyltransferase, mitochondrial (ENSG00000119927), score: 0.53 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.57 GPR128G protein-coupled receptor 128 (ENSG00000144820), score: 0.54 GPR152G protein-coupled receptor 152 (ENSG00000175514), score: 0.59 GPTglutamic-pyruvate transaminase (alanine aminotransferase) (ENSG00000167701), score: 0.5 GUCA2Bguanylate cyclase activator 2B (uroguanylin) (ENSG00000044012), score: 0.65 GYS2glycogen synthase 2 (liver) (ENSG00000111713), score: 0.58 H2AFY2H2A histone family, member Y2 (ENSG00000099284), score: -0.63 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (ENSG00000049239), score: 0.49 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.51 HCKhemopoietic cell kinase (ENSG00000101336), score: 0.51 HEBP1heme binding protein 1 (ENSG00000013583), score: 0.52 HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) (ENSG00000134240), score: 0.49 HPXhemopexin (ENSG00000110169), score: 0.53 HRASLS2HRAS-like suppressor 2 (ENSG00000133328), score: 0.63 HRGhistidine-rich glycoprotein (ENSG00000113905), score: 0.54 HS3ST3A1heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 (ENSG00000153976), score: 0.53 HS3ST3B1heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 (ENSG00000125430), score: 0.52 IFT20intraflagellar transport 20 homolog (Chlamydomonas) (ENSG00000109083), score: 0.5 IGF1insulin-like growth factor 1 (somatomedin C) (ENSG00000017427), score: 0.51 IGFALSinsulin-like growth factor binding protein, acid labile subunit (ENSG00000099769), score: 0.59 IGFBP1insulin-like growth factor binding protein 1 (ENSG00000146678), score: 0.61 IGSF6immunoglobulin superfamily, member 6 (ENSG00000140749), score: 0.5 IL10RAinterleukin 10 receptor, alpha (ENSG00000110324), score: 0.5 IL1R2interleukin 1 receptor, type II (ENSG00000115590), score: 0.66 IL2interleukin 2 (ENSG00000109471), score: 0.58 INHBAinhibin, beta A (ENSG00000122641), score: 0.51 INHBCinhibin, beta C (ENSG00000175189), score: 0.53 INHBEinhibin, beta E (ENSG00000139269), score: 0.51 INSIG1insulin induced gene 1 (ENSG00000186480), score: 0.53 IRF2BP2interferon regulatory factor 2 binding protein 2 (ENSG00000168264), score: 0.52 ITGADintegrin, alpha D (ENSG00000156886), score: 0.51 ITIH1inter-alpha (globulin) inhibitor H1 (ENSG00000055957), score: 0.52 ITIH3inter-alpha (globulin) inhibitor H3 (ENSG00000162267), score: 0.55 ITIH4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) (ENSG00000055955), score: 0.52 IVDisovaleryl-CoA dehydrogenase (ENSG00000128928), score: 0.5 KLHL14kelch-like 14 (Drosophila) (ENSG00000197705), score: 0.67 KLKB1kallikrein B, plasma (Fletcher factor) 1 (ENSG00000164344), score: 0.51 KRT28keratin 28 (ENSG00000173908), score: 1 KRT36keratin 36 (ENSG00000126337), score: 0.56 KRT80keratin 80 (ENSG00000167767), score: 0.49 LBPlipopolysaccharide binding protein (ENSG00000129988), score: 0.52 LDLRlow density lipoprotein receptor (ENSG00000130164), score: 0.58 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.57 LGMNlegumain (ENSG00000100600), score: 0.49 LIPMlipase, family member M (ENSG00000173239), score: 0.85 LOC100292202similar to solute carrier family 25, member 25 (ENSG00000148339), score: 0.5 LRG1leucine-rich alpha-2-glycoprotein 1 (ENSG00000171236), score: 0.49 LRRC25leucine rich repeat containing 25 (ENSG00000175489), score: 0.5 LYPD3LY6/PLAUR domain containing 3 (ENSG00000124466), score: 0.71 MARCOmacrophage receptor with collagenous structure (ENSG00000019169), score: 0.55 MASP2mannan-binding lectin serine peptidase 2 (ENSG00000009724), score: 0.57 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.58 MCFD2multiple coagulation factor deficiency 2 (ENSG00000180398), score: 0.55 MIER2mesoderm induction early response 1, family member 2 (ENSG00000105556), score: -0.5 MOCOSmolybdenum cofactor sulfurase (ENSG00000075643), score: 0.57 MTHFD1methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase (ENSG00000100714), score: 0.52 MUTmethylmalonyl CoA mutase (ENSG00000146085), score: 0.53 MVDmevalonate (diphospho) decarboxylase (ENSG00000167508), score: 0.51 NAAAN-acylethanolamine acid amidase (ENSG00000138744), score: 0.53 NADKNAD kinase (ENSG00000008130), score: 0.5 NAGAN-acetylgalactosaminidase, alpha- (ENSG00000198951), score: 0.54 NFAM1NFAT activating protein with ITAM motif 1 (ENSG00000235568), score: 0.53 NIPAL1NIPA-like domain containing 1 (ENSG00000163293), score: 0.52 NPC1L1NPC1 (Niemann-Pick disease, type C1, gene)-like 1 (ENSG00000015520), score: 0.52 NR1I2nuclear receptor subfamily 1, group I, member 2 (ENSG00000144852), score: 0.6 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.52 NSDHLNAD(P) dependent steroid dehydrogenase-like (ENSG00000147383), score: 0.55 NT5M5',3'-nucleotidase, mitochondrial (ENSG00000205309), score: -0.52 NUMBnumb homolog (Drosophila) (ENSG00000133961), score: 0.49 NYXnyctalopin (ENSG00000188937), score: 0.55 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.65 ONECUT2one cut homeobox 2 (ENSG00000119547), score: 0.49 OR10H3olfactory receptor, family 10, subfamily H, member 3 (ENSG00000171936), score: 0.71 OSBPL11oxysterol binding protein-like 11 (ENSG00000144909), score: 0.54 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.66 P2RX3purinergic receptor P2X, ligand-gated ion channel, 3 (ENSG00000109991), score: 0.54 PAEPprogestagen-associated endometrial protein (ENSG00000122133), score: 0.72 PAPSS13'-phosphoadenosine 5'-phosphosulfate synthase 1 (ENSG00000138801), score: -0.53 PARP15poly (ADP-ribose) polymerase family, member 15 (ENSG00000173200), score: 0.54 PARVGparvin, gamma (ENSG00000138964), score: 0.54 PCSK6proprotein convertase subtilisin/kexin type 6 (ENSG00000140479), score: 0.54 PCSK9proprotein convertase subtilisin/kexin type 9 (ENSG00000169174), score: 0.51 PCYT2phosphate cytidylyltransferase 2, ethanolamine (ENSG00000185813), score: 0.53 PEMTphosphatidylethanolamine N-methyltransferase (ENSG00000133027), score: 0.61 PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (ENSG00000158571), score: 0.58 PFN2profilin 2 (ENSG00000070087), score: -0.56 PGLYRP2peptidoglycan recognition protein 2 (ENSG00000161031), score: 0.55 PKD2polycystic kidney disease 2 (autosomal dominant) (ENSG00000118762), score: -0.55 PLA2G2Dphospholipase A2, group IID (ENSG00000117215), score: 0.79 PM20D1peptidase M20 domain containing 1 (ENSG00000162877), score: 0.53 PON1paraoxonase 1 (ENSG00000005421), score: 0.55 PORP450 (cytochrome) oxidoreductase (ENSG00000127948), score: 0.54 PPAPDC1Bphosphatidic acid phosphatase type 2 domain containing 1B (ENSG00000147535), score: 0.53 PRDM4PR domain containing 4 (ENSG00000110851), score: -0.5 PRHOXNBparahox cluster neighbor (ENSG00000183463), score: 0.97 PROL1proline rich, lacrimal 1 (ENSG00000171199), score: 0.68 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.58 PRSSL1protease, serine-like 1 (ENSG00000185198), score: 0.83 PSKH2protein serine kinase H2 (ENSG00000147613), score: 0.81 PSMB2proteasome (prosome, macropain) subunit, beta type, 2 (ENSG00000126067), score: 0.52 PTCRApre T-cell antigen receptor alpha (ENSG00000171611), score: 0.65 PTGER2prostaglandin E receptor 2 (subtype EP2), 53kDa (ENSG00000125384), score: 0.56 PYGLphosphorylase, glycogen, liver (ENSG00000100504), score: 0.52 RANBP10RAN binding protein 10 (ENSG00000141084), score: 0.63 RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (ENSG00000173166), score: 0.6 RBP1retinol binding protein 1, cellular (ENSG00000114115), score: 0.5 RDH16retinol dehydrogenase 16 (all-trans) (ENSG00000139547), score: 0.55 RGS13regulator of G-protein signaling 13 (ENSG00000127074), score: 0.86 RGS18regulator of G-protein signaling 18 (ENSG00000150681), score: 0.6 RHBDD3rhomboid domain containing 3 (ENSG00000100263), score: 0.5 RNASE1ribonuclease, RNase A family, 1 (pancreatic) (ENSG00000129538), score: -0.64 RNASE6ribonuclease, RNase A family, k6 (ENSG00000169413), score: 0.49 RNF149ring finger protein 149 (ENSG00000163162), score: 0.51 RNF166ring finger protein 166 (ENSG00000158717), score: 0.49 RPP40ribonuclease P/MRP 40kDa subunit (ENSG00000124787), score: 0.52 RPS6KA2ribosomal protein S6 kinase, 90kDa, polypeptide 2 (ENSG00000071242), score: -0.51 RRAGDRas-related GTP binding D (ENSG00000025039), score: -0.54 SCARB1scavenger receptor class B, member 1 (ENSG00000073060), score: 0.52 SDC2syndecan 2 (ENSG00000169439), score: 0.58 SDSserine dehydratase (ENSG00000135094), score: 0.5 SEC14L3SEC14-like 3 (S. cerevisiae) (ENSG00000100012), score: 0.64 SEC14L4SEC14-like 4 (S. cerevisiae) (ENSG00000133488), score: 0.61 SEC16BSEC16 homolog B (S. cerevisiae) (ENSG00000120341), score: 0.54 SEC22CSEC22 vesicle trafficking protein homolog C (S. cerevisiae) (ENSG00000093183), score: -0.55 SEC24ASEC24 family, member A (S. cerevisiae) (ENSG00000113615), score: 0.56 SEL1Lsel-1 suppressor of lin-12-like (C. elegans) (ENSG00000071537), score: 0.52 SELOselenoprotein O (ENSG00000073169), score: 0.52 SERPINA11serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 (ENSG00000186910), score: 0.56 SERPINA12serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 (ENSG00000165953), score: 0.8 SERPINA4serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 (ENSG00000100665), score: 0.51 SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 (ENSG00000170099), score: 0.51 SERPINA7serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 (ENSG00000123561), score: 0.62 SERPINA9serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 (ENSG00000170054), score: 0.51 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.5 SERPIND1serpin peptidase inhibitor, clade D (heparin cofactor), member 1 (ENSG00000099937), score: 0.53 SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin (ENSG00000088827), score: 0.56 SIGMAR1sigma non-opioid intracellular receptor 1 (ENSG00000147955), score: 0.55 SIRPB2signal-regulatory protein beta 2 (ENSG00000196209), score: 0.55 SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 1 (ENSG00000100652), score: 0.59 SLC11A1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 (ENSG00000018280), score: 0.5 SLC16A2solute carrier family 16, member 2 (monocarboxylic acid transporter 8) (ENSG00000147100), score: 0.56 SLC17A2solute carrier family 17 (sodium phosphate), member 2 (ENSG00000112337), score: 0.52 SLC17A4solute carrier family 17 (sodium phosphate), member 4 (ENSG00000146039), score: 0.51 SLC19A3solute carrier family 19, member 3 (ENSG00000135917), score: 0.6 SLC22A1solute carrier family 22 (organic cation transporter), member 1 (ENSG00000175003), score: 0.55 SLC25A15solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 (ENSG00000102743), score: 0.6 SLC26A3solute carrier family 26, member 3 (ENSG00000091138), score: 0.55 SLC30A10solute carrier family 30, member 10 (ENSG00000196660), score: 0.5 SLC35C1solute carrier family 35, member C1 (ENSG00000181830), score: 0.52 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.58 SLC39A9solute carrier family 39 (zinc transporter), member 9 (ENSG00000029364), score: 0.54 SLC41A2solute carrier family 41, member 2 (ENSG00000136052), score: 0.53 SLC45A3solute carrier family 45, member 3 (ENSG00000158715), score: 0.57 SLC46A1solute carrier family 46 (folate transporter), member 1 (ENSG00000076351), score: 0.71 SLC46A3solute carrier family 46, member 3 (ENSG00000139508), score: 0.5 SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (ENSG00000103546), score: 0.57 SLC7A6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (ENSG00000103064), score: -0.52 SLC9A8solute carrier family 9 (sodium/hydrogen exchanger), member 8 (ENSG00000197818), score: 0.52 SLCO1B1solute carrier organic anion transporter family, member 1B1 (ENSG00000134538), score: 0.61 SLCO1B3solute carrier organic anion transporter family, member 1B3 (ENSG00000111700), score: 0.58 SMPDL3Asphingomyelin phosphodiesterase, acid-like 3A (ENSG00000172594), score: 0.57 SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) (ENSG00000172164), score: 0.5 SOAT2sterol O-acyltransferase 2 (ENSG00000167780), score: 0.83 SPIRE1spire homolog 1 (Drosophila) (ENSG00000134278), score: -0.59 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.56 SRCRB4Dscavenger receptor cysteine rich domain containing, group B (4 domains) (ENSG00000146700), score: 0.63 SRPRsignal recognition particle receptor (docking protein) (ENSG00000182934), score: 0.51 STAB2stabilin 2 (ENSG00000136011), score: 0.59 STARD5StAR-related lipid transfer (START) domain containing 5 (ENSG00000172345), score: 0.58 SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 (ENSG00000105398), score: 0.53 SYT8synaptotagmin VIII (ENSG00000149043), score: 0.57 TATtyrosine aminotransferase (ENSG00000198650), score: 0.59 TBX19T-box 19 (ENSG00000143178), score: 0.49 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.49 TECTBtectorin beta (ENSG00000119913), score: 0.6 TFR2transferrin receptor 2 (ENSG00000106327), score: 0.51 TGFBItransforming growth factor, beta-induced, 68kDa (ENSG00000120708), score: 0.49 TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) (ENSG00000196781), score: 0.49 TLR1toll-like receptor 1 (ENSG00000174125), score: 0.66 TLR6toll-like receptor 6 (ENSG00000174130), score: 0.63 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.55 TM7SF2transmembrane 7 superfamily member 2 (ENSG00000149809), score: 0.56 TMEM154transmembrane protein 154 (ENSG00000170006), score: 0.62 TMEM195transmembrane protein 195 (ENSG00000187546), score: 0.5 TMEM199transmembrane protein 199 (ENSG00000004139), score: 0.53 TMEM20transmembrane protein 20 (ENSG00000176273), score: 0.56 TNFAIP8L2tumor necrosis factor, alpha-induced protein 8-like 2 (ENSG00000163154), score: 0.64 TPST1tyrosylprotein sulfotransferase 1 (ENSG00000169902), score: 0.52 TRIM68tripartite motif-containing 68 (ENSG00000167333), score: -0.6 TRPM1transient receptor potential cation channel, subfamily M, member 1 (ENSG00000134160), score: 0.5 TRPM5transient receptor potential cation channel, subfamily M, member 5 (ENSG00000070985), score: 0.87 TSPAN3tetraspanin 3 (ENSG00000140391), score: -0.55 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.58 UNC93Aunc-93 homolog A (C. elegans) (ENSG00000112494), score: 0.53 UROC1urocanase domain containing 1 (ENSG00000159650), score: 0.61 VMO1vitelline membrane outer layer 1 homolog (chicken) (ENSG00000182853), score: 0.52 VSIG4V-set and immunoglobulin domain containing 4 (ENSG00000155659), score: 0.51 VWCEvon Willebrand factor C and EGF domains (ENSG00000167992), score: 0.71 XDHxanthine dehydrogenase (ENSG00000158125), score: 0.61 ZBED2zinc finger, BED-type containing 2 (ENSG00000177494), score: 0.5 ZNF512zinc finger protein 512 (ENSG00000243943), score: -0.58

Non-Entrez genes

ENSG00000044012Unknown, score: 0.77 ENSG00000004139Unknown, score: 0.79 ENSG00000119523Unknown, score: 0.81

Id	species	tissue	sex	individual
ppa_lv_f_ca1	ppa	lv	f	_
mml_lv_f_ca1	mml	lv	f	_
mml_lv_m_ca1	mml	lv	m	_