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reproduction

The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism.

skeletal system development

The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).

renal system process involved in regulation of blood volume

A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.

regionalization

The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

circulatory system process

A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.

renal system process

A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism.

renal system process involved in regulation of systemic arterial blood pressure

Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

regulation of systemic arterial blood pressure

The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

anion transport

The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

female pregnancy

The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

blood circulation

The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

embryo development ending in birth or egg hatching

The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.

anterior/posterior pattern formation

The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules.

calcium-independent cell-cell adhesion

The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction.

reproductive process

A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

biological adhesion

The attachment of a cell or organism to a substrate or other organism.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

chordate embryonic development

The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic morphogenesis

The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form.

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

multi-organism process

Any process by which an organism has an effect on another organism of the same or different species.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

NA

reproductive process

A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.

cell adhesion

The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

female pregnancy

The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.

embryo development

The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.

pattern specification process

Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.

embryonic morphogenesis

The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ morphogenesis

Morphogenesis, during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

organ morphogenesis

Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

embryonic organ development

Development, taking place during the embryonic phase, of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

renal system process involved in regulation of blood volume

A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.

skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized. Morphogenesis pertains to the creation of form.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

embryonic skeletal system development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure.

renal system process involved in regulation of systemic arterial blood pressure

Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

embryonic skeletal system morphogenesis

The process by which the anatomical structures of the skeleton are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

brush border

Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

sodium channel activity

Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

inorganic anion exchanger activity

NA

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

fucosyltransferase activity

Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.

anion transmembrane transporter activity

Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

monovalent inorganic cation transmembrane transporter activity

Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:solute antiporter activity

Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

anion exchanger activity

NA

transferase activity

Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

transferase activity, transferring glycosyl groups

Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).

transferase activity, transferring hexosyl groups

Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).

3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity

Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

inorganic cation transmembrane transporter activity

Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

amiloride-sensitive sodium channel activity

NA

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006811	9.852e-14	10.95	45 AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSPRY, CALCA, CLCN5, CLCNKA, CLDN16, CYP27B1, EGF, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, PRSS8, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC4A1, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4, TRPC7, TRPV4, VDR, WNK4	663	ion transport
GO:0007588	9.325e-12	0.7759	14 AQP2, AQP3, AQP6, ATP6V0A4, ATP6V1B1, CLCN5, CLCNKA, CLDN16, KCNJ1, KCNK5, NPHS2, SCNN1A, SCNN1B, SCNN1G	47	excretion
GO:0006812	2.853e-11	7.892	35 AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSPRY, CALCA, CYP27B1, EGF, FXYD2, KCNE3, KCNJ1, KCNK5, PRSS8, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC22A13, SLC22A2, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4, TRPC7, TRPV4, VDR	478	cation transport
GO:0055085	5.707e-09	9.691	35 AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, CLCN5, CLCNKA, EGF, KCNH6, RHCG, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC23A3, SLC30A2, SLC39A5, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC7A7, SLC9A4, TRIP6, TRPC7, TRPV4	587	transmembrane transport
GO:0030001	2.946e-08	6.769	28 AQP2, BSPRY, CALCA, CYP27B1, EGF, FXYD2, KCNE3, KCNJ1, KCNK5, PRSS8, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4, TRPC7, TRPV4, VDR	410	metal ion transport
GO:0015672	3.913e-08	4.193	22 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, FXYD2, KCNE3, KCNJ1, KCNK5, PRSS8, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC34A1, SLC34A3, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4	254	monovalent inorganic cation transport
GO:0006814	1.450e-07	1.932	15 FXYD2, PRSS8, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC34A1, SLC34A3, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4	117	sodium ion transport
GO:0006810	1.939e-06	36.75	69 AP1M2, AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSPRY, CALCA, CLCN5, CLCNKA, CLDN16, CRYAA, CUBN, CYP27B1, EGF, FAM3B, FOLR1, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, NPHS2, PRLR, PRSS8, RAB19, RAB25, RAB38, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SERPINB7, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC23A3, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC4A1, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, STAP1, STRA6, TMED4, TRIP6, TRPC7, TRPV4, VDR, WNK4	2226	transport
GO:0051234	3.016e-06	37.18	69 AP1M2, AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSPRY, CALCA, CLCN5, CLCNKA, CLDN16, CRYAA, CUBN, CYP27B1, EGF, FAM3B, FOLR1, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, NPHS2, PRLR, PRSS8, RAB19, RAB25, RAB38, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SERPINB7, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC23A3, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC4A1, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, STAP1, STRA6, TMED4, TRIP6, TRPC7, TRPV4, VDR, WNK4	2252	establishment of localization
GO:0051179	1.246e-05	42.81	74 AP1M2, AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSPRY, CALCA, CLCN5, CLCNKA, CLDN16, CRYAA, CUBN, CYP27B1, EGF, F2RL1, FAM3B, FOLR1, FXYD2, HOXA7, KCNE3, KCNH6, KCNJ1, KCNK5, LMX1B, NPHS2, PKHD1, PRLR, PRSS8, RAB19, RAB25, RAB38, RHCG, S100A2, SCIN, SCNN1A, SCNN1B, SCNN1G, SERPINB7, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC23A3, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC4A1, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, STAP1, STRA6, TMED4, TRIP6, TRPC7, TRPV4, VDR, WNK4	2593	localization
GO:0046903	1.868e-04	6.571	21 AQP2, AQP3, AQP6, ATP6V0A4, ATP6V1B1, CLCN5, CLCNKA, CLDN16, EGF, FAM3B, KCNJ1, KCNK5, NPHS2, PRLR, SCIN, SCNN1A, SCNN1B, SCNN1G, SLC22A2, TRPV4, VDR	398	secretion
GO:0006820	3.350e-04	1.271	9 SLC13A3, SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLC34A1, SLC34A3, SLC4A1, WNK4	77	anion transport
GO:0001501	3.830e-03	3.682	13 ARSE, BARX2, HOXA10, HOXA7, HOXB5, HOXC10, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, PTH1R, VDR	223	skeletal system development
GO:0016338	5.047e-03	0.2642	4 CLDN16, CLDN19, CLDN4, CLDN8	16	calcium-independent cell-cell adhesion
GO:0009952	5.487e-03	1.915	9 HOXA10, HOXA7, HOXB5, HOXC10, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9	116	anterior/posterior pattern formation
GO:0007565	5.498e-03	1.502	8 AQP2, CALCA, CYP27B1, HSD11B2, PAPPA, PRLR, TFCP2L1, VDR	91	female pregnancy
GO:0048704	5.641e-03	0.7925	6 HOXA7, HOXB5, HOXD10, HOXD3, HOXD4, HOXD9	48	embryonic skeletal system morphogenesis
GO:0048706	5.873e-03	1.139	7 HOXA7, HOXB5, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9	69	embryonic skeletal system development
GO:0001977	9.162e-03	0.1321	3 AQP2, AQP3, HSD11B2	8	renal system process involved in regulation of blood volume
GO:0050801	1.002e-02	5.877	16 ATP6V0A4, ATP6V1B1, CALCA, CASR, CLDN16, CYP27B1, F2RL1, PRX, RHCG, SLC30A2, SLC34A1, SLC34A3, SLC4A1, SLC9A4, TRPV4, VDR	356	ion homeostasis
GO:0003073	1.193e-02	0.6108	5 AQP2, AQP3, CALCA, HSD11B2, REN	37	regulation of systemic arterial blood pressure
GO:0015711	1.193e-02	0.6108	5 SLC13A3, SLC22A11, SLC22A12, SLC22A6, SLC22A8	37	organic anion transport
GO:0009954	1.239e-02	0.3467	4 HOXA10, HOXC10, HOXD10, HOXD9	21	proximal/distal pattern formation
GO:0045616	1.241e-02	0.1486	3 AQP3, CYP27B1, HOXA7	9	regulation of keratinocyte differentiation
GO:0030855	1.424e-02	2.245	9 AQP3, CYP27B1, ELF5, EVPL, HOXA7, HOXB5, PAX2, RHCG, TFCP2L1	136	epithelial cell differentiation
GO:0042592	1.546e-02	10.8	23 AQP2, ATP6V0A4, ATP6V1B1, CALCA, CASR, CLDN16, CUBN, CYP27B1, F2RL1, NOX4, PKHD1, PRX, PTGER3, RHCG, SLC22A12, SLC30A2, SLC34A1, SLC34A3, SLC4A1, SLC9A4, TRIM10, TRPV4, VDR	654	homeostatic process
GO:0048562	1.634e-02	1.833	8 CRYAA, FOXI1, HOXA7, HOXB5, HOXD10, HOXD3, HOXD4, HOXD9	111	embryonic organ morphogenesis
GO:0048598	2.036e-02	4.557	13 CRYAA, FOXI1, GCM1, HOXA10, HOXA7, HOXB5, HOXC10, HOXD10, HOXD3, HOXD4, HOXD9, TINAG, TRIM15	276	embryonic morphogenesis
GO:0003071	2.071e-02	0.1816	3 AQP2, AQP3, HSD11B2	11	renal system process involved in regulation of systemic arterial blood pressure
GO:0003002	2.130e-02	2.922	10 HOXA10, HOXA7, HOXB5, HOXC10, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B	177	regionalization
GO:0010979	2.385e-02	0.04953	2 CYP27B1, VDR	3	regulation of vitamin D 24-hydroxylase activity
GO:0010980	2.385e-02	0.04953	2 CYP27B1, VDR	3	positive regulation of vitamin D 24-hydroxylase activity
GO:0055080	2.425e-02	4.094	12 ATP6V0A4, ATP6V1B1, CALCA, CASR, CLDN16, CYP27B1, F2RL1, RHCG, SLC30A2, SLC9A4, TRPV4, VDR	248	cation homeostasis
GO:0048705	2.936e-02	1.601	7 BARX2, HOXA7, HOXB5, HOXD10, HOXD3, HOXD4, HOXD9	97	skeletal system morphogenesis
GO:0045604	2.995e-02	0.2146	3 AQP3, CYP27B1, HOXA7	13	regulation of epidermal cell differentiation
GO:0048934	3.857e-02	0.06604	2 HOXD10, HOXD9	4	peripheral nervous system neuron differentiation
GO:0048935	3.857e-02	0.06604	2 HOXD10, HOXD9	4	peripheral nervous system neuron development
GO:0070561	3.857e-02	0.06604	2 CYP27B1, VDR	4	vitamin D receptor signaling pathway
GO:0071305	3.857e-02	0.06604	2 CYP27B1, VDR	4	cellular response to vitamin D
GO:0006885	3.860e-02	0.5118	4 ATP6V0A4, ATP6V1B1, RHCG, SLC9A4	31	regulation of pH
GO:0010959	4.407e-02	1.304	6 AQP2, CALCA, EGF, KCNE3, PRSS8, SCNN1B	79	regulation of metal ion transport
GO:0033280	4.742e-02	0.2642	3 AQP3, CYP27B1, VDR	16	response to vitamin D

Id	Pvalue	ExpCount	Count	Size	Term
GO:0045177	1.010e-16	2.854	27 AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, CDHR2, CLCN5, CUBN, DPEP1, EPCAM, MUC1, PKHD1, PROM2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC34A3, SLC4A9, SLC5A12, SLC5A8, SLC9A4, UMOD, USH1C	170	apical part of cell
GO:0016324	6.436e-16	2.267	24 AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, CDHR2, CUBN, DPEP1, EPCAM, MUC1, PKHD1, PROM2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC22A11, SLC22A12, SLC34A3, SLC5A12, SLC5A8, SLC9A4, UMOD	135	apical plasma membrane
GO:0044459	1.231e-10	26.73	65 AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, B3GNT3, BSND, CASR, CDHR2, CLCN5, CLCNKA, CLDN16, CLDN19, CLDN4, CLDN8, CUBN, DPEP1, EPCAM, EVPL, F2RL1, FOLR1, FXYD2, KCNH6, KCNJ1, KCNK5, KL, MUC1, NOX4, NPHS2, PKHD1, PROM2, PTGER3, PTH1R, RAB25, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC16A4, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC34A1, SLC34A3, SLC39A5, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, TACSTD2, TRIP6, TRPV4, UMOD, WNK4	1592	plasma membrane part
GO:0031224	2.232e-10	62.41	109 APCDD1L, AQP2, AQP3, AQP6, ATP6V0A4, B3GNT3, BSND, C12orf59, C1orf186, C9orf71, CA12, CASR, CDH16, CDHR2, CDHR5, CLCN5, CLCNKA, CLDN16, CLDN19, CLDN4, CLDN8, CLRN3, DPEP1, EGF, EPCAM, F2RL1, FAM151A, FCAMR, FMO1, FOLR1, FUT3, FUT6, FXYD2, GGT6, GPR110, GPR114, HEPACAM2, HHLA2, ILDR1, ITM2B, KCNE3, KCNH6, KCNJ1, KCNK5, KL, MUC1, MUC13, NOX4, NPHS2, PDZK1IP1, PKHD1, PRLR, PROM2, PRSS8, PTGER3, PTH1R, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA3, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC23A3, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC44A4, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, SUSD2, TACSTD2, TMC4, TMED4, TMEM101, TMEM106A, TMEM139, TMEM171, TMEM174, TMEM72, TMPRSS4, TRIP6, TRPC7, TRPV4, TSPAN33, UMOD, UNC5CL, XPNPEP2	3717	intrinsic to membrane
GO:0016021	9.576e-10	61.08	106 APCDD1L, AQP2, AQP3, AQP6, ATP6V0A4, B3GNT3, BSND, C12orf59, C1orf186, C9orf71, CA12, CASR, CDH16, CDHR2, CDHR5, CLCN5, CLCNKA, CLDN16, CLDN19, CLDN4, CLDN8, CLRN3, EGF, EPCAM, F2RL1, FAM151A, FCAMR, FMO1, FOLR1, FUT3, FUT6, FXYD2, GGT6, GPR110, GPR114, HEPACAM2, HHLA2, ILDR1, ITM2B, KCNE3, KCNH6, KCNJ1, KCNK5, KL, MUC1, MUC13, NOX4, NPHS2, PDZK1IP1, PKHD1, PRLR, PROM2, PRSS8, PTGER3, PTH1R, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA3, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC23A3, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC44A4, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, SUSD2, TACSTD2, TMC4, TMED4, TMEM101, TMEM106A, TMEM139, TMEM171, TMEM174, TMEM72, TMPRSS4, TRIP6, TRPC7, TRPV4, TSPAN33, UNC5CL	3638	integral to membrane
GO:0044425	1.979e-09	71.98	117 AP1M2, APCDD1L, AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, B3GNT3, BSND, C12orf59, C1orf186, C9orf71, CA12, CASR, CDH16, CDHR2, CDHR5, CLCN5, CLCNKA, CLDN16, CLDN19, CLDN4, CLDN8, CLRN3, CUBN, DPEP1, EGF, EPCAM, EVPL, F2RL1, FAM151A, FCAMR, FMO1, FOLR1, FUT3, FUT6, FXYD2, GGT6, GPR110, GPR114, HEPACAM2, HHLA2, ILDR1, ITM2B, KCNE3, KCNH6, KCNJ1, KCNK5, KL, MUC1, MUC13, NOX4, NPHS2, PDZK1IP1, PKHD1, PRLR, PROM2, PRSS8, PTGER3, PTH1R, RAB25, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA3, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC23A3, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC44A4, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, SUSD2, TACSTD2, TMC4, TMED4, TMEM101, TMEM106A, TMEM139, TMEM171, TMEM174, TMEM72, TMPRSS4, TRIP6, TRPC7, TRPV4, TSPAN33, UMOD, UNC5CL, WNK4, XPNPEP2	4287	membrane part
GO:0005886	6.720e-09	44.06	84 AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, B3GNT3, BSND, CASR, CDH16, CDHR2, CDHR5, CLCN5, CLCNKA, CLDN16, CLDN19, CLDN4, CLDN8, CUBN, DPEP1, EGF, EPCAM, EVPL, F2RL1, FCAMR, FOLR1, FXYD2, GPR110, GPR114, ILDR1, ITM2B, KCNH6, KCNJ1, KCNK5, KL, MUC1, MUC13, NOX4, NPHS2, PKHD1, PROM2, PRSS8, PRX, PTGER3, PTH1R, RAB19, RAB25, RAB38, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC34A1, SLC34A3, SLC39A5, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, TACSTD2, TRIP6, TRPV4, UMOD, WNK4, XPNPEP2	2624	plasma membrane
GO:0016020	4.931e-08	86.44	128 ACPP, AP1M2, APCDD1L, AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, B3GNT3, BSND, BSPRY, C12orf59, C1orf186, C9orf71, CA12, CASR, CDH16, CDHR2, CDHR5, CLCN5, CLCNKA, CLDN16, CLDN19, CLDN4, CLDN8, CLRN3, CUBN, CYP27B1, DPEP1, EGF, EPCAM, EVPL, F2RL1, FAM151A, FCAMR, FMO1, FOLR1, FUT3, FUT6, FXYD2, GGT6, GPR110, GPR114, HEPACAM2, HHLA2, ILDR1, ITM2B, KCNE3, KCNH6, KCNJ1, KCNK5, KL, MUC1, MUC13, NOX4, NPHS2, PAPPA, PAPPA2, PDZK1IP1, PKHD1, PLA2G4F, PRLR, PROM2, PRSS8, PRX, PTGER3, PTH1R, RAB19, RAB25, RAB38, REN, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA3, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC23A3, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC44A4, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, SUSD2, TACSTD2, TFCP2L1, TMC4, TMED4, TMEM101, TMEM106A, TMEM139, TMEM171, TMEM174, TMEM72, TMPRSS4, TRIP6, TRPC7, TRPV4, TSPAN33, UMOD, UNC5CL, WNK4, XPNPEP2	5148	membrane
GO:0016323	1.710e-07	3.224	18 AQP2, AQP3, ATP6V1B1, BSND, CLDN19, EPCAM, NOX4, PROM2, RHCG, SLC22A6, SLC22A8, SLC39A5, SLC4A1, SLC4A9, SLC7A7, SLC9A4, ST14, TRIP6	192	basolateral plasma membrane
GO:0016471	7.354e-05	0.1175	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	7	vacuolar proton-transporting V-type ATPase complex
GO:0031226	1.629e-04	15.85	35 AQP6, B3GNT3, BSND, CASR, CLCN5, CLCNKA, CLDN4, F2RL1, FOLR1, FXYD2, KCNH6, KCNJ1, KCNK5, KL, MUC1, NPHS2, PKHD1, PTGER3, PTH1R, RHCG, SCNN1G, SLC12A3, SLC16A4, SLC22A11, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC34A1, SLC4A1, SLC6A19, SLC7A7, ST14, TACSTD2, TRIP6	944	intrinsic to plasma membrane
GO:0005887	2.525e-04	15.51	34 AQP6, B3GNT3, BSND, CASR, CLCN5, CLCNKA, CLDN4, F2RL1, FOLR1, FXYD2, KCNH6, KCNJ1, KCNK5, KL, MUC1, NPHS2, PTGER3, PTH1R, RHCG, SCNN1G, SLC12A3, SLC16A4, SLC22A11, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC34A1, SLC4A1, SLC6A19, SLC7A7, ST14, TACSTD2, TRIP6	924	integral to plasma membrane
GO:0031526	8.782e-04	0.403	5 ATP6V0A4, CUBN, SLC22A12, SLC34A1, SLC34A3	24	brush border membrane
GO:0033176	1.720e-03	0.2519	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	15	proton-transporting V-type ATPase complex
GO:0031253	2.523e-03	1.528	8 ATP6V0A4, CUBN, DPEP1, PROM2, RAB25, SLC22A12, SLC34A1, SLC34A3	91	cell projection membrane
GO:0005774	4.967e-03	1.713	8 ACPP, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, CUBN, PLA2G4F, SLC30A2	102	vacuolar membrane
GO:0005903	4.986e-03	0.6045	5 ATP6V0A4, CUBN, SLC22A12, SLC34A1, SLC34A3	36	brush border
GO:0044437	6.953e-03	1.813	8 ACPP, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, CUBN, PLA2G4F, SLC30A2	108	vacuolar part
GO:0034706	1.840e-02	0.2351	3 SCNN1A, SCNN1B, SCNN1G	14	sodium channel complex
GO:0016469	2.065e-02	0.5205	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	31	proton-transporting two-sector ATPase complex
GO:0005923	2.589e-02	0.9235	5 CLDN16, CLDN19, CLDN4, CLDN8, WNK4	55	tight junction
GO:0070160	2.589e-02	0.9235	5 CLDN16, CLDN19, CLDN4, CLDN8, WNK4	55	occluding junction
GO:0005773	4.376e-02	3.728	10 ACPP, AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, CUBN, HEXA, PLA2G4F, SLC30A2	222	vacuole
GO:0043296	4.685e-02	1.091	5 CLDN16, CLDN19, CLDN4, CLDN8, WNK4	65	apical junction complex

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022857	2.029e-14	11.39	47 AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, CLCN5, CLCNKA, CLDN16, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, TRPC7, TRPV4	712	transmembrane transporter activity
GO:0005215	4.074e-13	14.58	51 AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, BSND, CLCN5, CLCNKA, CLDN16, CUBN, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, RBP2, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC23A3, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, TRPC7, TRPV4	912	transporter activity
GO:0022891	7.071e-12	10.38	41 AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCN5, CLCNKA, CLDN16, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC16A4, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC4A1, SLC4A9, SLC5A2, SLC6A19, SLC7A7, SLC9A4, TRPC7, TRPV4	649	substrate-specific transmembrane transporter activity
GO:0015075	1.785e-10	9.035	36 AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCN5, CLCNKA, CLDN16, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC22A11, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC4A1, SLC4A9, SLC5A2, SLC6A19, SLC9A4, TRPC7, TRPV4	565	ion transmembrane transporter activity
GO:0015291	2.428e-10	2.558	20 CLCN5, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A6, SLC22A8, SLC34A1, SLC34A3, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC9A4	160	secondary active transmembrane transporter activity
GO:0022892	4.907e-10	12.06	41 AQP2, AQP3, AQP6, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCN5, CLCNKA, CLDN16, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC16A4, SLC22A11, SLC22A12, SLC22A13, SLC22A2, SLC22A6, SLC22A8, SLC30A2, SLC34A1, SLC34A3, SLC39A5, SLC4A1, SLC4A9, SLC5A2, SLC6A19, SLC7A7, SLC9A4, TRPC7, TRPV4	754	substrate-specific transporter activity
GO:0022804	2.489e-09	4.429	24 ATP6V0A4, ATP6V1B1, CLCN5, FXYD2, SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC22A11, SLC22A6, SLC22A8, SLC34A1, SLC34A3, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4	277	active transmembrane transporter activity
GO:0008509	5.859e-07	1.887	14 AQP6, BSND, CLCN5, CLCNKA, SLC12A1, SLC12A3, SLC13A3, SLC22A11, SLC22A6, SLC22A8, SLC34A1, SLC34A3, SLC4A1, SLC4A9	118	anion transmembrane transporter activity
GO:0008324	6.773e-07	6.988	26 ATP6V0A4, ATP6V0D2, ATP6V1B1, CLDN16, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A1, SLC12A3, SLC13A3, SLC22A13, SLC22A2, SLC30A2, SLC34A3, SLC39A5, SLC5A2, SLC6A19, SLC9A4, TRPC7, TRPV4	437	cation transmembrane transporter activity
GO:0015293	1.069e-05	1.711	12 SLC12A1, SLC12A3, SLC13A3, SLC16A12, SLC16A4, SLC16A9, SLC34A1, SLC34A3, SLC5A12, SLC5A2, SLC5A8, SLC6A19	107	symporter activity
GO:0005452	5.100e-05	0.1919	5 SLC22A11, SLC22A6, SLC22A8, SLC4A1, SLC4A9	12	inorganic anion exchanger activity
GO:0015297	1.295e-04	0.8635	8 CLCN5, SLC22A11, SLC22A6, SLC22A8, SLC47A2, SLC4A1, SLC4A9, SLC9A4	54	antiporter activity
GO:0015380	2.200e-04	0.2558	5 SLC22A11, SLC22A6, SLC22A8, SLC4A1, SLC4A9	16	anion exchanger activity
GO:0015301	2.971e-04	0.2718	5 SLC22A11, SLC22A6, SLC22A8, SLC4A1, SLC4A9	17	anion:anion antiporter activity
GO:0022803	7.750e-04	5.165	17 AQP2, AQP3, AQP6, BSND, CLCN5, CLCNKA, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G, SLC5A8, TRPC7, TRPV4	323	passive transmembrane transporter activity
GO:0022838	1.640e-03	4.973	16 AQP2, AQP3, AQP6, BSND, CLCN5, CLCNKA, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G, TRPC7, TRPV4	311	substrate-specific channel activity
GO:0015300	2.077e-03	0.6716	6 SLC22A11, SLC22A6, SLC22A8, SLC4A1, SLC4A9, SLC9A4	42	solute:solute antiporter activity
GO:0015267	2.344e-03	5.149	16 AQP2, AQP3, AQP6, BSND, CLCN5, CLCNKA, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G, TRPC7, TRPV4	322	channel activity
GO:0022890	2.656e-03	2.638	11 ATP6V0A4, ATP6V0D2, ATP6V1B1, CLDN16, FXYD2, RHCG, SLC13A3, SLC34A3, SLC5A2, SLC6A19, SLC9A4	165	inorganic cation transmembrane transporter activity
GO:0015280	4.749e-03	0.1119	3 SCNN1A, SCNN1B, SCNN1G	7	amiloride-sensitive sodium channel activity
GO:0015077	6.139e-03	2.015	9 ATP6V0A4, ATP6V0D2, ATP6V1B1, FXYD2, SLC13A3, SLC34A3, SLC5A2, SLC6A19, SLC9A4	126	monovalent inorganic cation transmembrane transporter activity
GO:0017060	7.996e-03	0.03198	2 FUT3, FUT6	2	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
GO:0043565	1.160e-02	7.356	18 BARX2, ELF5, FOXI1, GATA3, HOXA10, HOXA7, HOXA9, HOXB5, HOXC10, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, PAX2, PAX8, VDR	460	sequence-specific DNA binding
GO:0008514	1.594e-02	0.1759	3 SLC22A11, SLC22A6, SLC22A8	11	organic anion transmembrane transporter activity
GO:0015250	1.594e-02	0.1759	3 AQP2, AQP3, AQP6	11	water channel activity
GO:0005372	1.976e-02	0.1919	3 AQP2, AQP3, AQP6	12	water transmembrane transporter activity
GO:0015101	1.976e-02	0.1919	3 RHCG, SLC22A13, SLC22A2	12	organic cation transmembrane transporter activity
GO:0003700	2.163e-02	11.32	23 BARX2, DMRT2, ELF5, FOXI1, GATA3, GCM1, GRHL2, HELT, HOXA10, HOXA7, HOXA9, HOXB5, HOXC10, HOXC6, HOXD10, HOXD3, HOXD4, HOXD9, LMX1B, PAX8, SIM2, TFCP2L1, VDR	708	sequence-specific DNA binding transcription factor activity
GO:0015294	2.486e-02	1.167	6 SLC12A1, SLC12A3, SLC13A3, SLC34A3, SLC5A2, SLC6A19	73	solute:cation symporter activity
GO:0005216	2.496e-02	4.813	13 BSND, CLCN5, CLCNKA, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G, TRPC7, TRPV4	301	ion channel activity
GO:0015296	2.768e-02	0.4797	4 SLC12A1, SLC12A3, SLC13A3, SLC34A3	30	anion:cation symporter activity
GO:0015103	3.025e-02	0.4957	4 AQP6, SLC34A1, SLC34A3, SLC4A1	31	inorganic anion transmembrane transporter activity
GO:0015168	3.154e-02	0.06396	2 AQP2, AQP3	4	glycerol transmembrane transporter activity
GO:0008235	3.624e-02	0.5277	4 CPA1, DPEP1, PEPD, XPNPEP2	33	metalloexopeptidase activity
GO:0050699	3.830e-02	0.2558	3 SCNN1A, SCNN1B, SCNN1G	16	WW domain binding
GO:0046873	4.421e-02	1.823	7 CLDN16, FXYD2, SLC13A3, SLC34A3, SLC39A5, SLC5A2, SLC6A19	114	metal ion transmembrane transporter activity
GO:0015166	4.627e-02	0.07995	2 AQP2, AQP3	5	polyol transmembrane transporter activity
GO:0015321	4.627e-02	0.07995	2 SLC34A1, SLC34A3	5	sodium-dependent phosphate transmembrane transporter activity
GO:0015347	4.627e-02	0.07995	2 SLC22A11, SLC22A6	5	sodium-independent organic anion transmembrane transporter activity
GO:0015665	4.627e-02	0.07995	2 AQP2, AQP3	5	alcohol transmembrane transporter activity

Id	Pvalue	ExpCount	Count	Size	Term
04960	1.045e-04	0.4043	6 FXYD2, HSD11B2, KCNJ1, SCNN1A, SCNN1B, SCNN1G	33	Aldosterone-regulated sodium reabsorption
04966	1.811e-04	0.2573	5 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3, SLC4A1	21	Collecting duct acid secretion
05110	2.568e-02	0.4901	4 ATP6V0A4, ATP6V0D2, ATP6V1B1, ATP6V1G3	40	Vibrio cholerae infection
00601	2.778e-02	0.2328	3 B3GNT3, FUT3, FUT6	19	Glycosphingolipid biosynthesis - lacto and neolacto series

No enriched terms

No enriched terms

Entrez genes

ABP1amiloride binding protein 1 (amine oxidase (copper-containing)) (ENSG00000002726), score: 0.64 ACOT11acyl-CoA thioesterase 11 (ENSG00000162390), score: 0.66 ACPPacid phosphatase, prostate (ENSG00000014257), score: 0.78 AP1M2adaptor-related protein complex 1, mu 2 subunit (ENSG00000129354), score: 0.69 APCDD1Ladenomatosis polyposis coli down-regulated 1-like (ENSG00000198768), score: 0.85 AQP2aquaporin 2 (collecting duct) (ENSG00000167580), score: 0.77 AQP3aquaporin 3 (Gill blood group) (ENSG00000165272), score: 0.61 AQP6aquaporin 6, kidney specific (ENSG00000086159), score: 0.67 ARSEarylsulfatase E (chondrodysplasia punctata 1) (ENSG00000157399), score: 0.63 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.71 ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (ENSG00000147614), score: 0.68 ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (ENSG00000116039), score: 0.72 ATP6V1G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 (ENSG00000151418), score: 0.62 B3GNT3UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (ENSG00000179913), score: 0.77 BARX2BARX homeobox 2 (ENSG00000043039), score: 0.67 BSNDBartter syndrome, infantile, with sensorineural deafness (Barttin) (ENSG00000162399), score: 0.69 BSPRYB-box and SPRY domain containing (ENSG00000119411), score: 0.64 C12orf59chromosome 12 open reading frame 59 (ENSG00000165685), score: 0.7 C19orf21chromosome 19 open reading frame 21 (ENSG00000099812), score: 0.66 C1orf106chromosome 1 open reading frame 106 (ENSG00000163362), score: 0.63 C1orf116chromosome 1 open reading frame 116 (ENSG00000182795), score: 0.62 C1orf186chromosome 1 open reading frame 186 (ENSG00000196533), score: 0.87 C2orf54chromosome 2 open reading frame 54 (ENSG00000172478), score: 0.65 C5orf32chromosome 5 open reading frame 32 (ENSG00000120306), score: 0.61 C9orf71chromosome 9 open reading frame 71 (ENSG00000181778), score: 0.61 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.7 CALCAcalcitonin-related polypeptide alpha (ENSG00000110680), score: 0.73 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.7 CDH16cadherin 16, KSP-cadherin (ENSG00000166589), score: 0.73 CDHR2cadherin-related family member 2 (ENSG00000074276), score: 0.67 CDHR5cadherin-related family member 5 (ENSG00000099834), score: 0.62 CLCN5chloride channel 5 (ENSG00000171365), score: 0.61 CLCNKAchloride channel Ka (ENSG00000186510), score: 0.7 CLDN16claudin 16 (ENSG00000113946), score: 0.67 CLDN19claudin 19 (ENSG00000164007), score: 0.81 CLDN4claudin 4 (ENSG00000189143), score: 0.68 CLDN8claudin 8 (ENSG00000156284), score: 0.7 CLRN3clarin 3 (ENSG00000180745), score: 0.63 CPA1carboxypeptidase A1 (pancreatic) (ENSG00000091704), score: 0.63 CRYAAcrystallin, alpha A (ENSG00000160202), score: 0.73 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.69 CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 1 (ENSG00000111012), score: 0.78 DMRT2doublesex and mab-3 related transcription factor 2 (ENSG00000173253), score: 0.66 DPEP1dipeptidase 1 (renal) (ENSG00000015413), score: 0.61 DUSP9dual specificity phosphatase 9 (ENSG00000130829), score: 0.63 EGFepidermal growth factor (ENSG00000138798), score: 0.7 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.71 EPCAMepithelial cell adhesion molecule (ENSG00000119888), score: 0.62 EPS8L1EPS8-like 1 (ENSG00000131037), score: 0.64 ERP27endoplasmic reticulum protein 27 (ENSG00000139055), score: 0.88 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.65 EVPLenvoplakin (ENSG00000167880), score: 0.67 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.64 FAM151Afamily with sequence similarity 151, member A (ENSG00000162391), score: 0.75 FAM3Bfamily with sequence similarity 3, member B (ENSG00000183844), score: 0.61 FBN3fibrillin 3 (ENSG00000142449), score: 0.68 FCAMRFc receptor, IgA, IgM, high affinity (ENSG00000162897), score: 0.79 FMO1flavin containing monooxygenase 1 (ENSG00000010932), score: 0.64 FOLR1folate receptor 1 (adult) (ENSG00000110195), score: 0.78 FOXI1forkhead box I1 (ENSG00000168269), score: 0.66 FRMD1FERM domain containing 1 (ENSG00000153303), score: 0.66 FUT3fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) (ENSG00000171124), score: 0.61 FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase) (ENSG00000156413), score: 0.68 FXYD2FXYD domain containing ion transport regulator 2 (ENSG00000137731), score: 0.66 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.64 GCM1glial cells missing homolog 1 (Drosophila) (ENSG00000137270), score: 0.7 GGT6gamma-glutamyltransferase 6 (ENSG00000167741), score: 0.94 GNPDA1glucosamine-6-phosphate deaminase 1 (ENSG00000113552), score: 0.62 GPR110G protein-coupled receptor 110 (ENSG00000153292), score: 0.65 GPR114G protein-coupled receptor 114 (ENSG00000159618), score: 0.74 GRHL2grainyhead-like 2 (Drosophila) (ENSG00000083307), score: 0.7 HELTHES/HEY-like transcription factor (ENSG00000187821), score: 0.75 HEPACAM2HEPACAM family member 2 (ENSG00000188175), score: 0.7 HEXAhexosaminidase A (alpha polypeptide) (ENSG00000213614), score: 0.65 HHLA2HERV-H LTR-associating 2 (ENSG00000114455), score: 0.87 HOXA10homeobox A10 (ENSG00000153807), score: 0.65 HOXA7homeobox A7 (ENSG00000122592), score: 0.67 HOXA9homeobox A9 (ENSG00000078399), score: 0.66 HOXB5homeobox B5 (ENSG00000120075), score: 0.67 HOXC10homeobox C10 (ENSG00000180818), score: 0.73 HOXC6homeobox C6 (ENSG00000197757), score: 0.61 HOXD10homeobox D10 (ENSG00000128710), score: 0.69 HOXD3homeobox D3 (ENSG00000128652), score: 0.63 HOXD4homeobox D4 (ENSG00000170166), score: 0.62 HOXD9homeobox D9 (ENSG00000128709), score: 0.65 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.62 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.74 ITM2Bintegral membrane protein 2B (ENSG00000136156), score: 0.61 KCNE3potassium voltage-gated channel, Isk-related family, member 3 (ENSG00000175538), score: 0.73 KCNH6potassium voltage-gated channel, subfamily H (eag-related), member 6 (ENSG00000173826), score: 0.86 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.71 KCNK5potassium channel, subfamily K, member 5 (ENSG00000164626), score: 0.64 KIAA1191KIAA1191 (ENSG00000122203), score: 0.67 KLklotho (ENSG00000133116), score: 0.66 KRT7keratin 7 (ENSG00000135480), score: 0.68 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.69 LMX1BLIM homeobox transcription factor 1, beta (ENSG00000136944), score: 0.67 LYG1lysozyme G-like 1 (ENSG00000144214), score: 0.64 MCCD1mitochondrial coiled-coil domain 1 (ENSG00000204511), score: 0.81 MIOXmyo-inositol oxygenase (ENSG00000100253), score: 0.69 MMP7matrix metallopeptidase 7 (matrilysin, uterine) (ENSG00000137673), score: 0.66 MUC1mucin 1, cell surface associated (ENSG00000185499), score: 0.67 MUC13mucin 13, cell surface associated (ENSG00000173702), score: 0.62 NCCRP1non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) (ENSG00000188505), score: 1 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.77 NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin) (ENSG00000116218), score: 0.69 ODAModontogenic, ameloblast asssociated (ENSG00000109205), score: 0.63 OVCH2ovochymase 2 (gene/pseudogene) (ENSG00000183378), score: 0.72 PABPC1Lpoly(A) binding protein, cytoplasmic 1-like (ENSG00000101104), score: 0.61 PAPPApregnancy-associated plasma protein A, pappalysin 1 (ENSG00000182752), score: 0.63 PAPPA2pappalysin 2 (ENSG00000116183), score: 0.64 PAX2paired box 2 (ENSG00000075891), score: 0.73 PAX8paired box 8 (ENSG00000125618), score: 0.7 PDZK1IP1PDZK1 interacting protein 1 (ENSG00000162366), score: 0.71 PEPDpeptidase D (ENSG00000124299), score: 0.67 PKHD1polycystic kidney and hepatic disease 1 (autosomal recessive) (ENSG00000170927), score: 0.62 PLA2G4Fphospholipase A2, group IVF (ENSG00000168907), score: 0.72 PPP1R14Dprotein phosphatase 1, regulatory (inhibitor) subunit 14D (ENSG00000166143), score: 0.69 PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit (ENSG00000111725), score: 0.71 PRLRprolactin receptor (ENSG00000113494), score: 0.71 PROM2prominin 2 (ENSG00000155066), score: 0.66 PRR13proline rich 13 (ENSG00000205352), score: 0.63 PRR15proline rich 15 (ENSG00000176532), score: 0.73 PRR15Lproline rich 15-like (ENSG00000167183), score: 0.63 PRSS8protease, serine, 8 (ENSG00000052344), score: 0.71 PRXperiaxin (ENSG00000105227), score: 0.66 PTGER3prostaglandin E receptor 3 (subtype EP3) (ENSG00000050628), score: 0.64 PTH1Rparathyroid hormone 1 receptor (ENSG00000160801), score: 0.7 RAB19RAB19, member RAS oncogene family (ENSG00000146955), score: 0.64 RAB25RAB25, member RAS oncogene family (ENSG00000132698), score: 0.72 RAB38RAB38, member RAS oncogene family (ENSG00000123892), score: 0.62 RASSF10Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 (ENSG00000189431), score: 0.67 RASSF6Ras association (RalGDS/AF-6) domain family member 6 (ENSG00000169435), score: 0.67 RBP2retinol binding protein 2, cellular (ENSG00000114113), score: 0.71 RENrenin (ENSG00000143839), score: 0.81 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.7 S100A2S100 calcium binding protein A2 (ENSG00000196754), score: 0.77 SCINscinderin (ENSG00000006747), score: 0.67 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.66 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.73 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.68 SERPINB7serpin peptidase inhibitor, clade B (ovalbumin), member 7 (ENSG00000166396), score: 0.64 SHISA3shisa homolog 3 (Xenopus laevis) (ENSG00000178343), score: 0.61 SIM2single-minded homolog 2 (Drosophila) (ENSG00000159263), score: 0.68 SLC12A1solute carrier family 12 (sodium/potassium/chloride transporters), member 1 (ENSG00000074803), score: 0.67 SLC12A3solute carrier family 12 (sodium/chloride transporters), member 3 (ENSG00000070915), score: 0.72 SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (ENSG00000158296), score: 0.62 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.63 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.62 SLC16A9solute carrier family 16, member 9 (monocarboxylic acid transporter 9) (ENSG00000165449), score: 0.64 SLC22A11solute carrier family 22 (organic anion/urate transporter), member 11 (ENSG00000168065), score: 0.68 SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12 (ENSG00000197891), score: 0.72 SLC22A13solute carrier family 22 (organic anion transporter), member 13 (ENSG00000172940), score: 0.91 SLC22A2solute carrier family 22 (organic cation transporter), member 2 (ENSG00000112499), score: 0.64 SLC22A6solute carrier family 22 (organic anion transporter), member 6 (ENSG00000197901), score: 0.68 SLC22A8solute carrier family 22 (organic anion transporter), member 8 (ENSG00000149452), score: 0.74 SLC23A3solute carrier family 23 (nucleobase transporters), member 3 (ENSG00000213901), score: 0.61 SLC30A2solute carrier family 30 (zinc transporter), member 2 (ENSG00000158014), score: 0.68 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.71 SLC34A3solute carrier family 34 (sodium phosphate), member 3 (ENSG00000198569), score: 0.74 SLC39A5solute carrier family 39 (metal ion transporter), member 5 (ENSG00000139540), score: 0.64 SLC44A4solute carrier family 44, member 4 (ENSG00000204385), score: 0.7 SLC47A2solute carrier family 47, member 2 (ENSG00000180638), score: 0.67 SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (ENSG00000004939), score: 0.7 SLC4A9solute carrier family 4, sodium bicarbonate cotransporter, member 9 (ENSG00000113073), score: 0.7 SLC5A10solute carrier family 5 (sodium/glucose cotransporter), member 10 (ENSG00000154025), score: 0.74 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.71 SLC5A2solute carrier family 5 (sodium/glucose cotransporter), member 2 (ENSG00000140675), score: 0.67 SLC5A8solute carrier family 5 (iodide transporter), member 8 (ENSG00000139357), score: 0.67 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.78 SLC7A7solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 (ENSG00000155465), score: 0.61 SLC9A4solute carrier family 9 (sodium/hydrogen exchanger), member 4 (ENSG00000180251), score: 0.7 SMPDL3Bsphingomyelin phosphodiesterase, acid-like 3B (ENSG00000130768), score: 0.62 SOSTsclerostin (ENSG00000167941), score: 0.75 ST14suppression of tumorigenicity 14 (colon carcinoma) (ENSG00000149418), score: 0.63 STAP1signal transducing adaptor family member 1 (ENSG00000035720), score: 0.66 STRA6stimulated by retinoic acid gene 6 homolog (mouse) (ENSG00000137868), score: 0.67 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.84 TACSTD2tumor-associated calcium signal transducer 2 (ENSG00000184292), score: 0.81 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.74 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.64 TMC4transmembrane channel-like 4 (ENSG00000167608), score: 0.78 TMED4transmembrane emp24 protein transport domain containing 4 (ENSG00000158604), score: 0.74 TMEM101transmembrane protein 101 (ENSG00000091947), score: 0.62 TMEM106Atransmembrane protein 106A (ENSG00000184988), score: 0.64 TMEM139transmembrane protein 139 (ENSG00000178826), score: 0.64 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.66 TMEM174transmembrane protein 174 (ENSG00000164325), score: 0.71 TMEM72transmembrane protein 72 (ENSG00000187783), score: 0.72 TMPRSS4transmembrane protease, serine 4 (ENSG00000137648), score: 0.89 TRIM10tripartite motif-containing 10 (ENSG00000204613), score: 0.67 TRIM15tripartite motif-containing 15 (ENSG00000204610), score: 0.73 TRIP6thyroid hormone receptor interactor 6 (ENSG00000087077), score: 0.62 TRPC7transient receptor potential cation channel, subfamily C, member 7 (ENSG00000069018), score: 0.79 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.66 TSPAN33tetraspanin 33 (ENSG00000158457), score: 0.72 TTC22tetratricopeptide repeat domain 22 (ENSG00000006555), score: 0.67 TUBAL3tubulin, alpha-like 3 (ENSG00000178462), score: 0.78 UMODuromodulin (ENSG00000169344), score: 0.72 UNC5CLunc-5 homolog C (C. elegans)-like (ENSG00000124602), score: 0.63 USH1CUsher syndrome 1C (autosomal recessive, severe) (ENSG00000006611), score: 0.64 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (ENSG00000111424), score: 0.61 VGLL1vestigial like 1 (Drosophila) (ENSG00000102243), score: 0.61 WDR72WD repeat domain 72 (ENSG00000166415), score: 0.63 WNK4WNK lysine deficient protein kinase 4 (ENSG00000126562), score: 0.64 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.72

Non-Entrez genes

ENSG00000189431Unknown, score: 0.64

Id	species	tissue	sex	individual
ptr_kd_m_ca1	ptr	kd	m	_
ppa_kd_f_ca1	ppa	kd	f	_
hsa_kd_f_ca1	hsa	kd	f	_
hsa_kd_m2_ca1	hsa	kd	m	2
hsa_kd_m1_ca1	hsa	kd	m	1