Under-expression is coded with green,
over-expression with red color.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
secretion
The controlled release of a substance by a cell, a group of cells, or a tissue.
transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.
ion transport
The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.
cation transport
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.
sodium ion transport
The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.
metal ion transport
The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.
excretion
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
monovalent inorganic cation transport
The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
localization
Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
all
NA
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
excretion
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
sodium ion transport
The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
brush border
Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
external side of plasma membrane
The side of the plasma membrane that is opposite to the side that faces the cytoplasm.
cell surface
The external part of the cell wall and/or plasma membrane.
apical plasma membrane
The region of the plasma membrane located at the apical end of the cell.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
cell projection membrane
The portion of the plasma membrane surrounding a cell surface projection.
brush border membrane
The portion of the plasma membrane surrounding the brush border.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
cation channel complex
An ion channel complex through which cations pass.
sodium channel complex
An ion channel complex through which sodium ions pass.
cell projection
A prolongation or process extending from a cell, e.g. a flagellum or axon.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell projection part
Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
apical part of cell
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
cell projection part
Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
external side of plasma membrane
The side of the plasma membrane that is opposite to the side that faces the cytoplasm.
apical plasma membrane
The region of the plasma membrane located at the apical end of the cell.
cell projection membrane
The portion of the plasma membrane surrounding a cell surface projection.
brush border membrane
The portion of the plasma membrane surrounding the brush border.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
protein binding
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
transporter activity
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
ion channel activity
Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
cation channel activity
Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
sodium channel activity
Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
transmembrane transporter activity
Enables the transfer of a substance from one side of a membrane to the other.
secondary active transmembrane transporter activity
Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
cation transmembrane transporter activity
Catalysis of the transfer of cation from one side of the membrane to the other.
ion transmembrane transporter activity
Catalysis of the transfer of an ion from one side of a membrane to the other.
monovalent inorganic cation transmembrane transporter activity
Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
amiloride-sensitive sodium channel activity
NA
symporter activity
Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.
protein domain specific binding
Interacting selectively and non-covalently with a specific domain of a protein.
passive transmembrane transporter activity
Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.
active transmembrane transporter activity
Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.
ligand-gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.
substrate-specific channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
inorganic cation transmembrane transporter activity
Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific transporter activity
Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
WW domain binding
Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions.
all
NA
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
ion channel activity
Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
cation channel activity
Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
amiloride-sensitive sodium channel activity
NA
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 04960 | 9.088e-04 | 0.3185 | 5 | 16 | Aldosterone-regulated sodium reabsorption |
| 04742 | 3.138e-02 | 0.199 | 3 | 10 | Taste transduction |
ACMSDaminocarboxymuconate semialdehyde decarboxylase (ENSG00000153086), score: 0.56 ACOT11acyl-CoA thioesterase 11 (ENSG00000162390), score: 0.59 ACPPacid phosphatase, prostate (ENSG00000014257), score: 0.83 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.59 BARX2BARX homeobox 2 (ENSG00000043039), score: 0.63 BBOX1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 (ENSG00000129151), score: 0.6 BDKRB1bradykinin receptor B1 (ENSG00000100739), score: 0.57 C9orf72chromosome 9 open reading frame 72 (ENSG00000147894), score: -0.55 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.72 CCNT2cyclin T2 (ENSG00000082258), score: -0.53 CDH6cadherin 6, type 2, K-cadherin (fetal kidney) (ENSG00000113361), score: 0.57 CLDN16claudin 16 (ENSG00000113946), score: 0.6 CRYAAcrystallin, alpha A (ENSG00000160202), score: 0.78 CRYL1crystallin, lambda 1 (ENSG00000165475), score: 0.58 CTSHcathepsin H (ENSG00000103811), score: 0.66 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.63 DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (ENSG00000153071), score: 0.58 DDCdopa decarboxylase (aromatic L-amino acid decarboxylase) (ENSG00000132437), score: 0.65 DPEP1dipeptidase 1 (renal) (ENSG00000015413), score: 0.67 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.64 EMILIN3elastin microfibril interfacer 3 (ENSG00000183798), score: 0.69 ESRP1epithelial splicing regulatory protein 1 (ENSG00000104413), score: 0.56 F2RL1coagulation factor II (thrombin) receptor-like 1 (ENSG00000164251), score: 0.64 FAM150Bfamily with sequence similarity 150, member B (ENSG00000189292), score: 0.79 FAM3Bfamily with sequence similarity 3, member B (ENSG00000183844), score: 0.59 FBXL5F-box and leucine-rich repeat protein 5 (ENSG00000118564), score: 0.61 FOXI1forkhead box I1 (ENSG00000168269), score: 0.69 GALNT10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) (ENSG00000164574), score: 0.6 GATA3GATA binding protein 3 (ENSG00000107485), score: 0.59 GPR114G protein-coupled receptor 114 (ENSG00000159618), score: 0.73 GPR56G protein-coupled receptor 56 (ENSG00000205336), score: 0.58 HOXA10homeobox A10 (ENSG00000153807), score: 0.6 HOXB7homeobox B7 (ENSG00000120087), score: 0.57 HOXD4homeobox D4 (ENSG00000170166), score: 0.62 HSD11B2hydroxysteroid (11-beta) dehydrogenase 2 (ENSG00000176387), score: 0.65 IL1RL1interleukin 1 receptor-like 1 (ENSG00000115602), score: 0.64 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.57 IMPA2inositol(myo)-1(or 4)-monophosphatase 2 (ENSG00000141401), score: 0.63 ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) (ENSG00000056345), score: 0.6 KCNE3potassium voltage-gated channel, Isk-related family, member 3 (ENSG00000175538), score: 0.7 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.69 KCNK5potassium channel, subfamily K, member 5 (ENSG00000164626), score: 0.6 KIAA0391KIAA0391 (ENSG00000100890), score: 0.6 KIF13Bkinesin family member 13B (ENSG00000197892), score: 0.58 KLklotho (ENSG00000133116), score: 0.6 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.68 LMX1BLIM homeobox transcription factor 1, beta (ENSG00000136944), score: 0.64 MMP7matrix metallopeptidase 7 (matrilysin, uterine) (ENSG00000137673), score: 0.78 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.66 NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin) (ENSG00000116218), score: 0.76 OLFM4olfactomedin 4 (ENSG00000102837), score: 0.96 PAPPA2pappalysin 2 (ENSG00000116183), score: 1 PEPDpeptidase D (ENSG00000124299), score: 0.66 PLA2G15phospholipase A2, group XV (ENSG00000103066), score: 0.56 PLA2R1phospholipase A2 receptor 1, 180kDa (ENSG00000153246), score: 0.68 PLATplasminogen activator, tissue (ENSG00000104368), score: 0.57 PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific) (ENSG00000197943), score: 0.63 PLEK2pleckstrin 2 (ENSG00000100558), score: 0.62 PLEKHJ1pleckstrin homology domain containing, family J member 1 (ENSG00000104886), score: 0.64 PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit (ENSG00000111725), score: 0.65 PROM2prominin 2 (ENSG00000155066), score: 0.62 PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 (ENSG00000110801), score: 0.57 PTCD1pentatricopeptide repeat domain 1 (ENSG00000106246), score: 0.57 PTPN1protein tyrosine phosphatase, non-receptor type 1 (ENSG00000196396), score: 0.59 RAB17RAB17, member RAS oncogene family (ENSG00000124839), score: 0.63 RAB7L1RAB7, member RAS oncogene family-like 1 (ENSG00000117280), score: 0.61 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.67 RNF152ring finger protein 152 (ENSG00000176641), score: 0.63 SCINscinderin (ENSG00000006747), score: 0.57 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.64 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.62 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.62 SGK196protein kinase-like protein SgK196 (ENSG00000185900), score: -0.55 SH3YL1SH3 domain containing, Ysc84-like 1 (S. cerevisiae) (ENSG00000035115), score: 0.56 SIM2single-minded homolog 2 (Drosophila) (ENSG00000159263), score: 0.58 SLC13A1solute carrier family 13 (sodium/sulfate symporters), member 1 (ENSG00000081800), score: 0.62 SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (ENSG00000158296), score: 0.59 SLC16A4solute carrier family 16, member 4 (monocarboxylic acid transporter 5) (ENSG00000168679), score: 0.61 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.6 SLC3A1solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1 (ENSG00000138079), score: 0.58 SLC44A3solute carrier family 44, member 3 (ENSG00000143036), score: 0.58 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.72 SLC5A9solute carrier family 5 (sodium/glucose cotransporter), member 9 (ENSG00000117834), score: 0.6 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.66 SLC7A9solute carrier family 7 (cationic amino acid transporter, y+ system), member 9 (ENSG00000021488), score: 0.62 SLC9A3solute carrier family 9 (sodium/hydrogen exchanger), member 3 (ENSG00000066230), score: 0.59 SLC9A4solute carrier family 9 (sodium/hydrogen exchanger), member 4 (ENSG00000180251), score: 0.85 SNX5sorting nexin 5 (ENSG00000089006), score: 0.6 SPTLC3serine palmitoyltransferase, long chain base subunit 3 (ENSG00000172296), score: 0.61 ST14suppression of tumorigenicity 14 (colon carcinoma) (ENSG00000149418), score: 0.56 STK32Bserine/threonine kinase 32B (ENSG00000152953), score: 0.6 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.62 TBC1D1TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 (ENSG00000065882), score: 0.59 TBX2T-box 2 (ENSG00000121068), score: 0.56 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.68 TINAGtubulointerstitial nephritis antigen (ENSG00000137251), score: 0.61 TM7SF3transmembrane 7 superfamily member 3 (ENSG00000064115), score: 0.68 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.56 TMPRSS2transmembrane protease, serine 2 (ENSG00000184012), score: 0.59 TMPRSS4transmembrane protease, serine 4 (ENSG00000137648), score: 0.73 TRPV4transient receptor potential cation channel, subfamily V, member 4 (ENSG00000111199), score: 0.6 WDR72WD repeat domain 72 (ENSG00000166415), score: 0.76 WNT8Bwingless-type MMTV integration site family, member 8B (ENSG00000075290), score: 0.66 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.63
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| ggo_kd_f_ca1 | ggo | kd | f | _ |
| ggo_kd_m_ca1 | ggo | kd | m | _ |
| hsa_kd_f_ca1 | hsa | kd | f | _ |
| hsa_kd_m1_ca1 | hsa | kd | m | 1 |
| hsa_kd_m2_ca1 | hsa | kd | m | 2 |
