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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

alcohol metabolic process

The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

oxidation reduction

The process of removal or addition of one or more electrons with or without the concomitant removal or addition of a proton or protons.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

tyrosine metabolic process

The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.

cellular amino acid derivative metabolic process

The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

cellular aromatic compound metabolic process

The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells.

coenzyme metabolic process

The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

steroid metabolic process

The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.

biosynthetic process

The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

serine family amino acid metabolic process

The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.

aromatic amino acid family metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

amine catabolic process

The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

response to biotic stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to organic substance

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.

lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

carboxylic acid metabolic process

The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

monocarboxylic acid metabolic process

The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

homeostatic process

Any biological process involved in the maintenance of an internal steady-state.

cholesterol homeostasis

Any process involved in the maintenance of an internal steady-state of cholesterol within an organism or cell.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

small molecule metabolic process

The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

chemical homeostasis

Any biological process involved in the maintenance of an internal steady-state of a chemical.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

cofactor metabolic process

The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

response to protein stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein stimulus.

lipid homeostasis

Any process involved in the maintenance of an internal steady-state of lipid within an organism or cell.

sterol homeostasis

Any process involved in the maintenance of an internal steady-state of sterol within an organism or cell.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

NA

cellular metabolic process

The chemical reactions and pathways by which individual cells transform chemical substances.

cellular nitrogen compound metabolic process

The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.

cellular catabolic process

The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

organic acid metabolic process

The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.

cellular amino acid and derivative metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells.

cellular ketone metabolic process

The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.

small molecule catabolic process

The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

cellular amine metabolic process

The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

organic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.

aromatic compound catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

oxoacid metabolic process

The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).

lipid biosynthetic process

The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

lipid catabolic process

The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

aromatic amino acid family metabolic process

The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

sterol metabolic process

The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

response to unfolded protein

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.

aromatic amino acid family catabolic process

The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).

cellular amino acid catabolic process

The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

cellular amino acid metabolic process

The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents.

carboxylic acid catabolic process

The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.

bile acid metabolic process

The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

peroxisome

A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

stored secretory granule

A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.

cell-cell junction

A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals.

endomembrane system

A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

cell junction

A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

organelle membrane

The lipid bilayer surrounding an organelle.

platelet alpha granule

A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

membrane-enclosed lumen

The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.

vesicle

Any small, fluid-filled, spherical organelle enclosed by membrane or protein.

vesicle lumen

The volume enclosed by the membrane or protein that forms a vesicle.

membrane-bounded vesicle

Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

microbody

Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

intercellular canaliculus

An extremely narrow tubular channel located between adjacent cells. An instance of this is the secretory canaliculi occurring between adjacent parietal cells in the gastric mucosa of vertebrates.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle lumen

The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

nuclear membrane-endoplasmic reticulum network

The continuous network of membranes encompassing the outer nuclear membrane and the endoplasmic reticulum.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

vesicle lumen

The volume enclosed by the membrane or protein that forms a vesicle.

cytoplasmic membrane-bounded vesicle

A membrane-bounded vesicle found in the cytoplasm of the cell.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

endoplasmic reticulum membrane

The lipid bilayer surrounding the endoplasmic reticulum.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

endoplasmic reticulum

The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).

cytoplasmic vesicle

A vesicle formed of membrane or protein, found in the cytoplasm of a cell.

microbody

Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

cytoplasmic vesicle part

Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.

subsynaptic reticulum

An elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cytoplasmic membrane-bounded vesicle lumen

The volume enclosed by the membrane of a cytoplasmic membrane-bounded vesicle.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

endoplasmic reticulum part

Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.

pore complex

Any small opening in a membrane that allows the passage of gases and/or liquids.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

membrane attack complex

A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow.

platelet alpha granule lumen

The volume enclosed by the membrane of the platelet alpha granule.

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

lipid transporter activity

Enables the directed movement of lipids into, out of, within or between cells.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

oxidoreductase activity

Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

lyase activity

Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

carbon-sulfur lyase activity

Catalysis of the elimination of H2S or substituted H2S.

vitamin binding

Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

carboxylic acid binding

Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).

cofactor binding

Interacting selectively and non-covalently with a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.

coenzyme binding

Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.

vitamin B6 binding

Interacting selectively and non-covalently with any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.

all

NA

pyridoxal phosphate binding

Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006082	1.014e-11	17.29	54 ACO1, ACOT12, ACSL5, AKR1D1, ALDH8A1, AMDHD1, ASPG, ATP8B1, AVPR1A, CCBL1, CCBL2, CDO1, CROT, CTH, CYP7B1, DARS, DCT, DMGDH, FABP2, FAR1, GCH1, GCLM, GNE, GNMT, GPT2, HAL, HAO1, HGD, HNF4A, IDH1, IGF1, KMO, LIPC, LPIN1, LPIN2, MAT1A, ME3, NPC1, NR1H4, NR5A2, OTC, PAH, PDP1, PEX7, PRKAB2, SARDH, SCLY, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2, TMEM195	228	organic acid metabolic process
GO:0019752	1.014e-11	17.29	54 ACO1, ACOT12, ACSL5, AKR1D1, ALDH8A1, AMDHD1, ASPG, ATP8B1, AVPR1A, CCBL1, CCBL2, CDO1, CROT, CTH, CYP7B1, DARS, DCT, DMGDH, FABP2, FAR1, GCH1, GCLM, GNE, GNMT, GPT2, HAL, HAO1, HGD, HNF4A, IDH1, IGF1, KMO, LIPC, LPIN1, LPIN2, MAT1A, ME3, NPC1, NR1H4, NR5A2, OTC, PAH, PDP1, PEX7, PRKAB2, SARDH, SCLY, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2, TMEM195	228	carboxylic acid metabolic process
GO:0043436	1.014e-11	17.29	54 ACO1, ACOT12, ACSL5, AKR1D1, ALDH8A1, AMDHD1, ASPG, ATP8B1, AVPR1A, CCBL1, CCBL2, CDO1, CROT, CTH, CYP7B1, DARS, DCT, DMGDH, FABP2, FAR1, GCH1, GCLM, GNE, GNMT, GPT2, HAL, HAO1, HGD, HNF4A, IDH1, IGF1, KMO, LIPC, LPIN1, LPIN2, MAT1A, ME3, NPC1, NR1H4, NR5A2, OTC, PAH, PDP1, PEX7, PRKAB2, SARDH, SCLY, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2, TMEM195	228	oxoacid metabolic process
GO:0042180	2.514e-11	17.67	54 ACO1, ACOT12, ACSL5, AKR1D1, ALDH8A1, AMDHD1, ASPG, ATP8B1, AVPR1A, CCBL1, CCBL2, CDO1, CROT, CTH, CYP7B1, DARS, DCT, DMGDH, FABP2, FAR1, GCH1, GCLM, GNE, GNMT, GPT2, HAL, HAO1, HGD, HNF4A, IDH1, IGF1, KMO, LIPC, LPIN1, LPIN2, MAT1A, ME3, NPC1, NR1H4, NR5A2, OTC, PAH, PDP1, PEX7, PRKAB2, SARDH, SCLY, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2, TMEM195	233	cellular ketone metabolic process
GO:0044281	2.810e-09	45.66	92 ABCA1, ACO1, ACOT12, ACSL5, ADAP2, ADRA1B, AKR1D1, ALDH2, ALDH8A1, AMDHD1, ASPG, ATP13A3, ATP8B1, ATPIF1, AVPR1A, BPHL, CA1, CCBL1, CCBL2, CDO1, CROT, CTH, CYP7B1, DARS, DCT, DHCR24, DMGDH, EVI5, FABP2, FAR1, FDXR, FGD6, GCH1, GCLM, GLO1, GMPR, GNAI1, GNE, GNMT, GPT2, H6PD, HAL, HAO1, HGD, HMGCR, HNF4A, IDH1, IGF1, KMO, LIPC, LPIN1, LPIN2, MAN2A1, MAT1A, ME3, NADK, NPC1, NR1H4, NR5A2, NSDHL, NSUN2, ONECUT1, OTC, PAH, PANK1, PCSK9, PCTP, PDE3B, PDP1, PEMT, PEX7, PPP1R3D, PRKAB2, PYGL, RGN, RRM2B, RXRA, SARDH, SCLY, SLC19A2, SLC35D1, SLC7A2, SLC7A6, SNX17, SQLE, ST3GAL2, TARS, TAT, TBC1D15, TDO2, TMEM195, TTPA	602	small molecule metabolic process
GO:0006629	3.480e-07	23.44	55 ABCA1, ACOT12, ACSL5, AKR1D1, ALDH8A1, ARV1, ASPG, ATP8B1, AVPR1A, CROT, CYP7B1, DHCR24, FABP2, FAR1, FDXR, GGPS1, GLT25D1, GM2A, GNE, GPLD1, HAO1, HMGCR, HNF4A, IAH1, LCLAT1, LIPC, LPGAT1, LPIN1, LPIN2, MTTP, NAPEPLD, NPC1, NR1H4, NR5A2, NSDHL, PAFAH2, PCSK9, PCTP, PDE3B, PEMT, PEX7, PGAP3, PLA2G12B, PLAA, PRKAB2, PRLR, RXRA, SDR42E1, SNX17, SQLE, ST3GAL5, ST6GALNAC4, STARD5, TMEM195, TTPA	309	lipid metabolic process
GO:0006520	5.516e-07	6.826	26 AMDHD1, ASPG, CCBL1, CCBL2, CDO1, CTH, DARS, DCT, DMGDH, GCLM, GNMT, GPT2, HAL, HGD, HNF4A, KMO, MAT1A, OTC, PAH, SARDH, SCLY, SLC7A2, SLC7A6, TARS, TAT, TDO2	90	cellular amino acid metabolic process
GO:0006519	7.836e-07	10.01	32 AMDHD1, ASPG, BPHL, CCBL1, CCBL2, CDO1, CTH, DARS, DCT, DMGDH, GCH1, GCLM, GLO1, GNMT, GPT2, HAL, HGD, HNF4A, IDH1, KMO, LIPC, MAT1A, OTC, PAH, PEMT, SARDH, SCLY, SLC7A2, SLC7A6, TARS, TAT, TDO2	132	cellular amino acid and derivative metabolic process
GO:0044106	1.338e-06	8.646	29 AMDHD1, ASPG, CCBL1, CCBL2, CDO1, CTH, DARS, DCT, DMGDH, GCH1, GCLM, GNMT, GPT2, HAL, HGD, HNF4A, KMO, LIPC, MAT1A, OTC, PAH, PEMT, SARDH, SCLY, SLC7A2, SLC7A6, TARS, TAT, TDO2	114	cellular amine metabolic process
GO:0051186	7.652e-05	5.157	19 ACO1, ACOT12, ALAS1, AMBP, CPOX, CTH, GCH1, GCLM, GLO1, H6PD, HMGCR, HPX, IDH1, KMO, MOCOS, NADK, PANK1, PDP1, TDO2	68	cofactor metabolic process
GO:0009308	1.217e-04	11.45	30 AMDHD1, ASPG, CCBL1, CCBL2, CDO1, CTH, DARS, DCT, DMGDH, GCH1, GCLM, GNMT, GPT2, HAL, HGD, HNF4A, KMO, LIPC, MAT1A, OTC, PAH, PEMT, SARDH, SCLY, SLC35D1, SLC7A2, SLC7A6, TARS, TAT, TDO2	151	amine metabolic process
GO:0008202	1.238e-04	5.84	20 ABCA1, AKR1D1, ATP8B1, CYP7B1, DHCR24, FDXR, HMGCR, LIPC, NPC1, NR1H4, NR5A2, NSDHL, PCSK9, PCTP, PRLR, RXRA, SDR42E1, SNX17, SQLE, STARD5	77	steroid metabolic process
GO:0032787	1.303e-04	9.708	27 ACOT12, ACSL5, AKR1D1, ALDH8A1, ATP8B1, AVPR1A, CROT, CYP7B1, FABP2, FAR1, GCH1, GNMT, HAO1, IDH1, IGF1, LIPC, LPIN1, LPIN2, ME3, NPC1, NR1H4, NR5A2, PDP1, PEX7, PRKAB2, SLC35D1, TMEM195	128	monocarboxylic acid metabolic process
GO:0009056	1.499e-04	31.55	59 ACO1, ACSL5, ADAP2, ADRA1B, AKR1D1, AMBP, AMDHD1, ASPG, ATG5, C10orf46, CASP8, CDO1, DERL1, DERL2, DHCR24, DMGDH, DNAJC3, EDEM1, EVI5, FAM176A, FBXL4, FBXL5, FGD6, GCH1, GM2A, H6PD, HAL, HAO1, HGD, IAH1, IDH1, IGF1, ITCH, KMO, LIPC, LPIN1, LYSMD3, NAPEPLD, NEDD4, NPC1, PAFAH2, PAH, PCSK9, PDE3B, PEX7, PLA2G12B, PSEN2, PSMA4, PSMD12, PYGL, RGN, SARDH, SNX17, TAT, TBC1D15, TDO2, TRIB2, UBR2, USP20	416	catabolic process
GO:0016054	2.243e-04	3.64	15 ACSL5, AKR1D1, AMDHD1, CDO1, DMGDH, HAL, HAO1, HGD, KMO, LPIN1, PAH, PEX7, SARDH, TAT, TDO2	48	organic acid catabolic process
GO:0046395	2.243e-04	3.64	15 ACSL5, AKR1D1, AMDHD1, CDO1, DMGDH, HAL, HAO1, HGD, KMO, LPIN1, PAH, PEX7, SARDH, TAT, TDO2	48	carboxylic acid catabolic process
GO:0008203	2.527e-04	2.806	13 ABCA1, AKR1D1, CYP7B1, DHCR24, FDXR, HMGCR, LIPC, NSDHL, PCSK9, PCTP, RXRA, SNX17, SQLE	37	cholesterol metabolic process
GO:0006732	4.561e-04	3.868	15 ACO1, ACOT12, CTH, GCH1, GCLM, GLO1, H6PD, HMGCR, IDH1, KMO, MOCOS, NADK, PANK1, PDP1, TDO2	51	coenzyme metabolic process
GO:0016125	5.834e-04	3.034	13 ABCA1, AKR1D1, CYP7B1, DHCR24, FDXR, HMGCR, LIPC, NSDHL, PCSK9, PCTP, RXRA, SNX17, SQLE	40	sterol metabolic process
GO:0044248	6.039e-04	26.39	50 ACO1, ACSL5, ADAP2, ADRA1B, AKR1D1, AMBP, AMDHD1, ATG5, C10orf46, CASP8, CDO1, DERL1, DERL2, DMGDH, DNAJC3, EDEM1, EVI5, FAM176A, FBXL4, FBXL5, FGD6, GCH1, GM2A, HAL, HAO1, HGD, IDH1, IGF1, ITCH, KMO, LIPC, LPIN1, NAPEPLD, NEDD4, NPC1, PAH, PCSK9, PDE3B, PEX7, PSEN2, PSMA4, PSMD12, RGN, SARDH, TAT, TBC1D15, TDO2, TRIB2, UBR2, USP20	348	cellular catabolic process
GO:0006066	1.243e-03	13.05	30 ABCA1, ADRA1B, AKR1D1, ALDH2, CYP7B1, DHCR24, DMGDH, FDXR, GCH1, GNE, GNMT, H6PD, HAO1, HMGCR, IGF1, LIPC, MAN2A1, NSDHL, ONECUT1, PAH, PCSK9, PCTP, PEMT, PPP1R3D, PYGL, RXRA, SLC35D1, SNX17, SQLE, ST3GAL2	172	alcohol metabolic process
GO:0009072	1.507e-03	0.6826	6 DCT, HGD, KMO, PAH, TAT, TDO2	9	aromatic amino acid family metabolic process
GO:0009074	1.615e-03	0.4551	5 HGD, KMO, PAH, TAT, TDO2	6	aromatic amino acid family catabolic process
GO:0055114	1.723e-03	14.64	32 AKR1D1, ALDH2, ALDH8A1, CDO1, CPOX, CYP7B1, DHCR24, DMGDH, FAR1, FDXR, GCLM, GMPR, H6PD, HAO1, HGD, HMGCR, IDH1, IYD, KMO, ME3, NSDHL, P4HTM, PAH, QSOX1, RRM2B, SARDH, SCCPDH, SDR42E1, SQLE, TDO2, TMEM195, TXNRD1	193	oxidation reduction
GO:0006575	1.909e-03	4.399	15 CCBL1, CCBL2, CDO1, CTH, DMGDH, GCH1, GCLM, GLO1, GNMT, IDH1, KMO, LIPC, PAH, PEMT, TDO2	58	cellular amino acid derivative metabolic process
GO:0008610	2.066e-03	10.85	26 ACSL5, AKR1D1, ALDH8A1, AVPR1A, CYP7B1, DHCR24, FAR1, FDXR, GGPS1, GLT25D1, GNE, HMGCR, LCLAT1, LIPC, LPGAT1, NSDHL, PEMT, PEX7, PGAP3, PRKAB2, PRLR, SDR42E1, SQLE, ST3GAL5, STARD5, TMEM195	143	lipid biosynthetic process
GO:0009063	2.257e-03	2.124	10 AMDHD1, CDO1, DMGDH, HAL, HGD, KMO, PAH, SARDH, TAT, TDO2	28	cellular amino acid catabolic process
GO:0006725	2.371e-03	3.489	13 DCT, GCH1, GNMT, HGD, KMO, MOCOS, PAH, PCBD2, PEMT, SLC19A2, SQLE, TAT, TDO2	46	cellular aromatic compound metabolic process
GO:0009310	2.994e-03	2.199	10 AMDHD1, CDO1, DMGDH, HAL, HGD, KMO, PAH, SARDH, TAT, TDO2	29	amine catabolic process
GO:0006570	3.209e-03	0.3034	4 DCT, HGD, PAH, TAT	4	tyrosine metabolic process
GO:0009069	4.159e-03	0.5309	5 CDO1, CTH, DMGDH, GCLM, SARDH	7	serine family amino acid metabolic process
GO:0006986	4.605e-03	1.896	9 CREB3L3, DERL1, DERL2, DNAJC3, EDEM1, EDEM2, ERN1, HERPUD1, TOR1A	25	response to unfolded protein
GO:0008206	5.277e-03	0.8343	6 AKR1D1, ATP8B1, CYP7B1, NPC1, NR1H4, NR5A2	11	bile acid metabolic process
GO:0042632	5.277e-03	0.8343	6 ABCA1, ABCG5, LIPC, NPC1, NR5A2, PCSK9	11	cholesterol homeostasis
GO:0055092	5.277e-03	0.8343	6 ABCA1, ABCG5, LIPC, NPC1, NR5A2, PCSK9	11	sterol homeostasis
GO:0016042	8.462e-03	4.551	14 ACSL5, AKR1D1, ASPG, GM2A, HAO1, IAH1, LIPC, LPIN1, NAPEPLD, PAFAH2, PDE3B, PEX7, PLA2G12B, SNX17	60	lipid catabolic process
GO:0019439	8.569e-03	0.6067	5 HGD, KMO, PAH, TAT, TDO2	8	aromatic compound catabolic process
GO:0055088	9.906e-03	1.289	7 ABCA1, ABCG5, HNF4A, LIPC, NPC1, NR5A2, PCSK9	17	lipid homeostasis
GO:0006957	1.083e-02	0.3792	4 C5, C8A, C8B, C8G	5	complement activation, alternative pathway
GO:0002455	1.533e-02	0.6826	5 C5, C8A, C8B, C8G, HPX	9	humoral immune response mediated by circulating immunoglobulin
GO:0044255	1.581e-02	15.4	30 ACOT12, ACSL5, ALDH8A1, ARV1, AVPR1A, CROT, FABP2, FAR1, GGPS1, GLT25D1, GM2A, GNE, GPLD1, HAO1, HMGCR, LCLAT1, LIPC, LPGAT1, LPIN1, LPIN2, NAPEPLD, PCSK9, PEMT, PEX7, PGAP3, PLAA, PRKAB2, ST3GAL5, ST6GALNAC4, TMEM195	203	cellular lipid metabolic process
GO:0008152	1.953e-02	201.5	231 A1CF, ABCA1, ABI2, ACO1, ACOT12, ACSL5, ADAP2, ADRA1B, AFAP1L2, AKR1D1, ALAS1, ALDH2, ALDH8A1, AMBP, AMDHD1, APBA3, ARID5B, ARV1, ASPG, ATG5, ATP13A3, ATP8B1, ATPIF1, AVPR1A, B4GALT2, BACH1, BPHL, BPNT1, C10orf46, C13orf15, C5, C5orf33, C8A, C8B, C8G, CA1, CASP8, CCBL1, CCBL2, CDK8, CDO1, CHUK, CNR2, CPB2, CPOX, CREB3L3, CREG1, CROT, CTH, CTSO, CYP7B1, DARS, DCLRE1A, DCT, DEPDC6, DERL1, DERL2, DHCR24, DMGDH, DNAJC3, DNTT, DPP4, DPYSL3, DUSP14, EDEM1, EGFR, ELK4, ERN1, EVI5, F10, F2, FABP2, FAM176A, FAR1, FBXL4, FBXL5, FBXO3, FDXR, FGD6, FN1, FUBP1, GCH1, GCLM, GDF2, GGPS1, GLO1, GLT25D1, GM2A, GMPR, GNAI1, GNE, GNMT, GPLD1, GPT2, GRPEL2, GXYLT1, H6PD, HAL, HAO1, HELB, HERPUD1, HGD, HMGCR, HNF4A, HNRNPR, HPX, HTRA1, IAH1, IDH1, IFT57, IGF1, IKBKE, ITCH, IYD, KCTD1, KLB, KLF15, KMO, LCLAT1, LECT1, LIPC, LPGAT1, LPIN1, LPIN2, LYSMD3, MAN2A1, MAP1D, MAT1A, MBIP, MCM10, MCRS1, ME3, MEAF6, MED8, MINPP1, MOCOS, MTTP, NADK, NAPEPLD, NECAB3, NEDD4, NPC1, NR1H4, NR5A2, NSDHL, NSUN2, ONECUT1, OTC, P4HTM, PAFAH2, PAH, PANK1, PAPSS2, PARD3, PCBD2, PCSK9, PCTP, PDE3B, PDIA6, PDP1, PEMT, PEX7, PGAP3, PLA2G12B, PLAA, PLAT, PLK3, PM20D1, POLR3G, PPM1B, PPP1R15B, PPP1R3D, PRKAB2, PRKD1, PRKD3, PRLR, PROZ, PSEN2, PSMA4, PSMD12, PUS10, PYGL, QSOX1, RGN, RRM2B, RXRA, SARDH, SCCPDH, SCLY, SDR42E1, SEC63, SEP15, SEPSECS, SIRT3, SLC19A2, SLC2A2, SLC35D1, SLC7A2, SLC7A6, SLIT3, SMARCA1, SNX17, SQLE, ST3GAL2, ST3GAL5, ST6GALNAC4, STARD5, TARS, TAT, TBC1D15, TDO2, TEC, TERT, TGDS, TGFBRAP1, TMEM195, TOR1A, TRIB2, TTPA, TULP3, TXNRD1, TYW3, UBR2, USP20, UVRAG, WDR36, ZAP70, ZBTB41, ZNF462, ZNF518B, ZNF827	2657	metabolic process
GO:0044282	2.392e-02	11.6	24 ACSL5, ADAP2, AKR1D1, AMDHD1, CDO1, DMGDH, EVI5, FGD6, GCH1, H6PD, HAL, HAO1, HGD, IGF1, KMO, LPIN1, PAH, PDE3B, PEX7, RGN, SARDH, TAT, TBC1D15, TDO2	153	small molecule catabolic process
GO:0006958	2.402e-02	0.4551	4 C5, C8A, C8B, C8G	6	complement activation, classical pathway
GO:0019835	2.402e-02	0.4551	4 C5, C8A, C8B, C8G	6	cytolysis
GO:0006534	2.406e-02	0.2275	3 CDO1, CTH, GCLM	3	cysteine metabolic process
GO:0006558	2.406e-02	0.2275	3 HGD, PAH, TAT	3	L-phenylalanine metabolic process
GO:0006559	2.406e-02	0.2275	3 HGD, PAH, TAT	3	L-phenylalanine catabolic process
GO:0070189	2.406e-02	0.2275	3 CCBL1, CCBL2, KMO	3	kynurenine metabolic process
GO:0006790	2.600e-02	3.489	11 CDO1, CTH, GCLM, GLO1, GNMT, IDH1, IGF1, PAPSS2, PEMT, SLC19A2, SLC35D1	46	sulfur metabolic process
GO:0006950	2.871e-02	46.72	68 AFAP1L2, ALB, ALDH2, AMBP, ATG5, AVPR1A, C5, C8A, C8B, C8G, CASP8, CDO1, CGRRF1, CHUK, CNR2, CPB2, CREB3L3, DCLRE1A, DERL1, DERL2, DHCR24, DNAJC3, DPP4, EDEM1, EDEM2, EGFR, ERN1, F10, F2, FGB, FGG, FN1, GCH1, GCLM, GMPR, HAO1, HERPUD1, HNF4A, HPX, HRG, IDH1, IFIH1, IGF1, IKBKE, IL1RAP, ITCH, JAG2, KMO, MBIP, MIA3, NEDD4, NPC1, PCSK9, PLAA, PLAT, POLR3G, PPP1R15B, PROZ, PSEN2, RRM2B, RXRA, SERPINA10, SERPINC1, SNN, TAT, TM4SF4, TOR1A, UVRAG	616	response to stress
GO:0042221	3.619e-02	39.59	59 ABCG5, ACO1, ACSL5, ADRA1B, ALDH2, AQP8, ATG5, AVPR1A, BPHL, C5, CASP8, CCRL1, CDO1, CHUK, CMTM6, CMTM8, CNR2, CPB2, CPOX, CREB3L3, CYP7B1, DERL1, DERL2, DHCR24, DNAJC3, DPP4, EDEM1, EDEM2, EGFR, ERN1, FGB, FGG, GCH1, GCLM, HAO1, HERPUD1, HNF4A, HPX, IDH1, JAG2, LECT2, LIFR, NEDD4, NPC1, NR1H4, PCSK9, PDE3B, PEMT, PLAT, PPP1R15B, PSEN2, RRM2B, RXRA, SERPINC1, SLIT3, SQLE, TAT, TOR1A, TTPA	522	response to chemical stimulus
GO:0006749	4.251e-02	0.5309	4 CTH, GCLM, GLO1, IDH1	7	glutathione metabolic process
GO:0009607	4.390e-02	8.798	19 ALDH2, CASP8, CHUK, CNR2, CREB3L3, DERL1, DERL2, DNAJC3, EDEM1, EDEM2, ERN1, GCH1, HERPUD1, IFIH1, ITCH, NR1H4, POLR3G, PPP1R15B, TOR1A	116	response to biotic stimulus
GO:0016053	4.704e-02	4.399	12 AKR1D1, AVPR1A, CDO1, CTH, CYP7B1, FAR1, LIPC, OTC, PAH, PRKAB2, SLC35D1, TMEM195	58	organic acid biosynthetic process
GO:0046394	4.704e-02	4.399	12 AKR1D1, AVPR1A, CDO1, CTH, CYP7B1, FAR1, LIPC, OTC, PAH, PRKAB2, SLC35D1, TMEM195	58	carboxylic acid biosynthetic process
GO:0006694	4.719e-02	3.261	10 AKR1D1, CYP7B1, DHCR24, FDXR, HMGCR, NSDHL, PRLR, SDR42E1, SQLE, STARD5	43	steroid biosynthetic process

Id	Pvalue	ExpCount	Count	Size	Term
GO:0044432	1.404e-06	16.81	42 ACSL5, ATL2, CLSTN1, CREB3L3, CYP7B1, DERL1, DERL2, DHCR24, DNAJC3, EDEM1, EDEM2, ERN1, FAM176A, GJB1, GLT25D1, H6PD, HERPUD1, HMGCR, LCLAT1, LPGAT1, LPIN1, LPIN2, MARCH5, MIA3, MINPP1, NECAB3, NSDHL, P4HTM, PDIA6, PEMT, PEX16, PGAP3, PSEN2, RCN2, SAR1B, SEC16B, SEC24D, SEC63, SEP15, SLC35D1, SQLE, TOR1A	227	endoplasmic reticulum part
GO:0005783	2.043e-06	26.37	56 A1CF, ACO1, ACSL5, ATL2, C7orf58, CLDN14, CLSTN1, CREB3L3, CYP7B1, DERL1, DERL2, DHCR24, DNAJC3, DPP4, EDEM1, EDEM2, ERN1, FAM176A, GJB1, GLT25D1, H6PD, HERPUD1, HMGCR, KIFAP3, LCLAT1, LPGAT1, LPIN1, LPIN2, MARCH5, MIA3, MINPP1, MTTP, NECAB3, NPC1, NSDHL, P4HTM, PCSK9, PDE3B, PDIA6, PEMT, PEX16, PGAP3, PLA2G12B, PSEN2, RCN2, SAR1B, SEC16B, SEC24D, SEC63, SEP15, SLC35D1, SLC39A6, SQLE, TMEM195, TOR1A, ZFYVE1	356	endoplasmic reticulum
GO:0071212	2.077e-06	17.7	43 ACSL5, ATL2, CLSTN1, CREB3L3, CYP7B1, DERL1, DERL2, DHCR24, DNAJC3, EDEM1, EDEM2, ERN1, FAM176A, GJB1, GLT25D1, H6PD, HERPUD1, HMGCR, LCLAT1, LPGAT1, LPIN1, LPIN2, MARCH5, MIA3, MINPP1, NECAB3, NSDHL, P4HTM, PCSK9, PDIA6, PEMT, PEX16, PGAP3, PSEN2, RCN2, SAR1B, SEC16B, SEC24D, SEC63, SEP15, SLC35D1, SQLE, TOR1A	239	subsynaptic reticulum
GO:0044444	3.433e-05	136.6	181 A1CF, ABCA1, ABCD3, ABI2, ACO1, ACOT12, ACSL5, ADAP2, AKR1D1, ALAS1, ALB, ALDH2, AMDHD1, AP3M1, ARCN1, ATG5, ATL2, ATPAF1, ATPIF1, AVPR1A, B4GALT2, BACH1, BBS2, BPHL, BPNT1, C13orf15, C16orf70, C2CD2, C5orf33, C7orf58, CASP8, CCBL1, CCBL2, CDO1, CHUK, CKAP5, CLCN6, CLDN14, CLSTN1, COL10A1, COPB2, CPOX, CREB3L3, CROT, CTSO, CYP7B1, DARS, DCT, DERL1, DERL2, DHCR24, DMGDH, DNAJC3, DPP4, EDEM1, EDEM2, EGFR, ERN1, EVI5, FABP2, FAM176A, FAR1, FBXL5, FDXR, FGB, FGD6, FGG, FN1, GCH1, GCLM, GJB1, GJB2, GLT25D1, GM2A, GNE, GNMT, GPT2, GRPEL2, H6PD, HAL, HAO1, HDDC2, HEBP1, HERPUD1, HMGCR, HRG, IDH1, IFT57, IGF1, IKBKE, ITCH, ITM2B, JAG2, KCTD5, KIFAP3, KMO, LAMP2, LCLAT1, LPGAT1, LPIN1, LPIN2, MAN2A1, MAP1D, MARCH5, ME3, MIA3, MINPP1, MTTP, NADK, NECAB3, NEDD4, NPC1, NSDHL, OTC, P4HTM, PANK1, PARD3, PCBD2, PCSK9, PCTP, PDE3B, PDIA6, PDP1, PEMT, PEX11A, PEX16, PEX7, PGAP3, PLA2G12B, PLAT, PPP1R15B, PRKAB2, PRKD1, PSEN2, PSTPIP2, QSOX1, RCN2, RDX, SAR1B, SARDH, SCCPDH, SCLY, SEC16B, SEC24D, SEC63, SEP15, SEPT6, SH3BP4, SIRT3, SLC17A8, SLC25A16, SLC25A25, SLC25A47, SLC2A2, SLC35D1, SLC39A6, SLIT3, SMEK1, SNN, SNX17, SPIRE1, SQLE, SSPN, ST3GAL2, ST3GAL5, ST6GALNAC4, STARD5, TARS, TAT, TBC1D15, TDO2, TM9SF2, TMEM195, TOMM70A, TOR1A, TTPA, TXNRD1, USP20, UVRAG, ZAP70, ZFYVE1	1844	cytoplasmic part
GO:0005789	1.128e-04	14.66	34 ACSL5, ATL2, CLSTN1, CREB3L3, CYP7B1, DERL1, DERL2, DHCR24, DNAJC3, EDEM1, ERN1, FAM176A, GJB1, HERPUD1, HMGCR, LCLAT1, LPGAT1, LPIN1, LPIN2, MARCH5, MIA3, NECAB3, NSDHL, P4HTM, PEMT, PEX16, PGAP3, PSEN2, SAR1B, SEC16B, SEC24D, SEC63, SLC35D1, SQLE	198	endoplasmic reticulum membrane
GO:0042175	2.053e-04	15.11	34 ACSL5, ATL2, CLSTN1, CREB3L3, CYP7B1, DERL1, DERL2, DHCR24, DNAJC3, EDEM1, ERN1, FAM176A, GJB1, HERPUD1, HMGCR, LCLAT1, LPGAT1, LPIN1, LPIN2, MARCH5, MIA3, NECAB3, NSDHL, P4HTM, PEMT, PEX16, PGAP3, PSEN2, SAR1B, SEC16B, SEC24D, SEC63, SLC35D1, SQLE	204	nuclear membrane-endoplasmic reticulum network
GO:0005579	1.016e-03	0.2962	4 C5, C8A, C8B, C8G	4	membrane attack complex
GO:0046581	8.800e-03	0.2222	3 ABCB11, ABCC2, DPP4	3	intercellular canaliculus
GO:0031093	9.510e-03	1.111	6 ALB, FGB, FGG, FN1, HRG, IGF1	15	platelet alpha granule lumen
GO:0005777	9.962e-03	2.444	9 ABCD3, CROT, FAR1, HAO1, HMGCR, IDH1, PEX11A, PEX16, PEX7	33	peroxisome
GO:0042579	9.962e-03	2.444	9 ABCD3, CROT, FAR1, HAO1, HMGCR, IDH1, PEX11A, PEX16, PEX7	33	microbody
GO:0031300	1.153e-02	4.666	13 ABCD3, DERL1, DERL2, EDEM1, ERN1, PEX11A, PEX16, PGAP3, QSOX1, SLC35D1, ST3GAL2, ST3GAL5, ST6GALNAC4	63	intrinsic to organelle membrane
GO:0005788	1.212e-02	2.518	9 DNAJC3, EDEM2, GLT25D1, H6PD, MINPP1, PDIA6, RCN2, SEP15, TOR1A	34	endoplasmic reticulum lumen
GO:0031983	1.319e-02	1.185	6 ALB, FGB, FGG, FN1, HRG, IGF1	16	vesicle lumen
GO:0060205	1.319e-02	1.185	6 ALB, FGB, FGG, FN1, HRG, IGF1	16	cytoplasmic membrane-bounded vesicle lumen
GO:0031301	1.663e-02	4.295	12 ABCD3, DERL1, DERL2, EDEM1, ERN1, PEX11A, PEX16, QSOX1, SLC35D1, ST3GAL2, ST3GAL5, ST6GALNAC4	58	integral to organelle membrane
GO:0044438	2.319e-02	1.333	6 ABCD3, CROT, FAR1, HMGCR, PEX11A, PEX16	18	microbody part
GO:0044439	2.319e-02	1.333	6 ABCD3, CROT, FAR1, HMGCR, PEX11A, PEX16	18	peroxisomal part
GO:0031091	2.996e-02	1.407	6 ALB, FGB, FGG, FN1, HRG, IGF1	19	platelet alpha granule
GO:0012505	3.914e-02	39.84	57 ACSL5, ARCN1, ATL2, B4GALT2, C16orf70, CLSTN1, COPB2, CREB3L3, CYP7B1, DCT, DERL1, DERL2, DHCR24, DNAJC3, EDEM1, EGFR, ERN1, FAM176A, GJB1, GJB2, HERPUD1, HMGCR, ITM2B, LAMP2, LCLAT1, LECT1, LPGAT1, LPIN1, LPIN2, MAN2A1, MARCH5, MIA3, NECAB3, NPC1, NSDHL, P4HTM, PARD3, PEMT, PEX16, PGAP3, PSEN2, QSOX1, RNF34, SAR1B, SEC16B, SEC24D, SEC63, SH3BP4, SLC17A8, SLC2A9, SLC35D1, SQLE, ST3GAL2, ST3GAL5, ST6GALNAC4, SUN1, TOR1A	538	endomembrane system
GO:0005778	4.793e-02	1.111	5 ABCD3, FAR1, HMGCR, PEX11A, PEX16	15	peroxisomal membrane
GO:0031903	4.793e-02	1.111	5 ABCD3, FAR1, HMGCR, PEX11A, PEX16	15	microbody membrane
GO:0031090	4.878e-02	49.92	68 ABCD3, ACSL5, ARCN1, ATL2, ATPIF1, B4GALT2, C16orf70, CASP8, CLCN6, CLSTN1, COPB2, CREB3L3, CYP7B1, DCT, DERL1, DERL2, DHCR24, DNAJC3, EDEM1, EGFR, ERN1, FAM176A, FAR1, GJB1, GJB2, GRPEL2, HERPUD1, HMGCR, IKBKE, ITM2B, KMO, LAMP2, LCLAT1, LPGAT1, LPIN1, LPIN2, MAN2A1, MARCH5, MIA3, NECAB3, NPC1, NSDHL, OTC, P4HTM, PEMT, PEX11A, PEX16, PGAP3, PSEN2, QSOX1, SAR1B, SEC16B, SEC24D, SEC63, SLC17A8, SLC25A16, SLC25A25, SLC25A47, SLC35D1, SNN, SQLE, ST3GAL2, ST3GAL5, ST6GALNAC4, SUN1, TM9SF2, TOMM70A, TOR1A	674	organelle membrane
GO:0005577	4.908e-02	0.3703	3 FGB, FGG, FN1	5	fibrinogen complex

Id	Pvalue	ExpCount	Count	Size	Term
GO:0048037	2.440e-07	5.942	25 ACBD5, ALAS1, ALB, CCBL1, CCBL2, CTH, DHCR24, DMGDH, GPT2, H6PD, HAO1, HMGCR, IDH1, KMO, ME3, MOCOS, PAH, PYGL, SARDH, SCLY, SIRT3, SQLE, TAT, TGDS, TXNRD1	83	cofactor binding
GO:0030170	1.171e-04	1.503	10 ALAS1, ALB, CCBL1, CCBL2, CTH, GPT2, MOCOS, PYGL, SCLY, TAT	21	pyridoxal phosphate binding
GO:0070279	1.171e-04	1.503	10 ALAS1, ALB, CCBL1, CCBL2, CTH, GPT2, MOCOS, PYGL, SCLY, TAT	21	vitamin B6 binding
GO:0019842	1.514e-04	3.938	16 ALAS1, ALB, C8G, CCBL1, CCBL2, CTH, DMGDH, GNMT, GPT2, MOCOS, P4HTM, PYGL, SCLY, SLC19A2, TAT, TTPA	55	vitamin binding
GO:0016491	1.541e-04	14.68	35 AKR1D1, ALDH2, ALDH8A1, CDO1, CPOX, CYP7B1, DCT, DHCR24, DMGDH, FAR1, FDXR, GCLM, GMPR, H6PD, HAO1, HGD, HMGCR, IDH1, IYD, KMO, ME3, NECAB3, NSDHL, P4HTM, PAH, PCBD2, QSOX1, RRM2B, SARDH, SCCPDH, SDR42E1, SQLE, TDO2, TMEM195, TXNRD1	205	oxidoreductase activity
GO:0031406	3.765e-04	3.795	15 ACBD5, ALB, DMGDH, FABP2, GNMT, HNF4A, NEDD4, NR1H4, OTC, P4HTM, PAH, PYGL, SLC19A2, TAT, TDO2	53	carboxylic acid binding
GO:0016846	4.594e-04	0.5728	6 CCBL1, CCBL2, CTH, GLO1, SCLY, TAT	8	carbon-sulfur lyase activity
GO:0003824	1.008e-03	128.2	166 A1CF, ABCA1, ABCB11, ABCC2, ABCD3, ABCG5, ACO1, ACOT12, ACSL5, AKR1D1, ALAS1, ALDH2, ALDH8A1, AMDHD1, ASPG, ATL2, ATP13A3, ATP8B1, B4GALT2, BPHL, BPNT1, BRAP, C11orf54, C12orf72, C5orf33, CA1, CASP8, CCBL1, CCBL2, CDK8, CDO1, CHUK, CPB2, CPOX, CROT, CTH, CTSO, CYP7B1, DARS, DCLRE1A, DCT, DHCR24, DIP2A, DMGDH, DNTT, DPP4, DPYSL3, DUSP14, DYNC2LI1, EDEM1, EDEM2, EGFR, ERN1, F10, F2, FAR1, FBXL5, FBXO3, FDXR, GCH1, GCLM, GGPS1, GLO1, GLT25D1, GM2A, GMPR, GNAI1, GNE, GNMT, GPLD1, GPT2, GXYLT1, H6PD, HAL, HAO1, HDDC2, HELB, HGD, HMGCR, HTRA1, IAH1, IDH1, IFIH1, IKBKE, ITCH, IYD, KIAA2018, KLB, KMO, LCLAT1, LIPC, LPGAT1, LPIN1, LPIN2, MAN2A1, MAP1D, MARCH5, MAT1A, ME3, MINPP1, MOCOS, MRAS, MYO1B, NADK, NAPEPLD, NECAB3, NEDD4, NSDHL, NSUN2, OTC, P4HTM, PAFAH2, PAH, PANK1, PAPSS2, PCBD2, PCSK9, PDE3B, PDIA6, PDP1, PEMT, PGAP3, PLA2G12B, PLAT, PLK3, PM20D1, POLR3G, PPM1B, PPP1R15B, PPP1R3D, PRKD1, PRKD3, PROZ, PSEN2, PSMA4, PUS10, PYGL, QSOX1, RNF34, RRM2B, SARDH, SCCPDH, SCLY, SDR42E1, SEPSECS, SIRT3, SMARCA1, SQLE, ST3GAL2, ST3GAL5, ST6GALNAC4, TARS, TAT, TDO2, TEC, TERT, TGDS, TMEM195, TOR1A, TRIB2, TXNRD1, TYW3, UBR2, USP20, ZAP70, ZDHHC6	1790	catalytic activity
GO:0005319	3.068e-03	1.432	8 ABCA1, ABCG5, ATP8B1, FABP2, GM2A, MTTP, NPC1, PCTP	20	lipid transporter activity
GO:0050662	3.796e-03	4.224	14 ACBD5, DHCR24, DMGDH, H6PD, HAO1, HMGCR, IDH1, KMO, ME3, SARDH, SIRT3, SQLE, TGDS, TXNRD1	59	coenzyme binding
GO:0008289	1.041e-02	10.95	24 ABCA1, ACBD5, ADAP2, AKR1D1, ALB, C8G, F10, FABP2, HNF4A, MTTP, NR1H4, NR5A2, OTC, PAFAH2, PARD3, PCTP, PEMT, PYGL, RXRA, SESTD1, SNX17, STARD5, TULP3, ZFYVE1	153	lipid binding
GO:0016597	1.259e-02	1.79	8 DMGDH, GNMT, NEDD4, OTC, PAH, SLC19A2, TAT, TDO2	25	amino acid binding
GO:0033293	1.768e-02	1.074	6 ACBD5, ALB, FABP2, HNF4A, NR1H4, PYGL	15	monocarboxylic acid binding
GO:0043176	2.868e-02	3.079	10 DMGDH, GNMT, NEDD4, OTC, PAH, PCTP, SESTD1, SLC19A2, TAT, TDO2	43	amine binding
GO:0015924	3.049e-02	0.5012	4 EDEM1, EDEM2, KIAA2018, MAN2A1	7	mannosyl-oligosaccharide mannosidase activity
GO:0016614	3.505e-02	2.148	8 AKR1D1, H6PD, HAO1, HMGCR, IDH1, ME3, NSDHL, SDR42E1	30	oxidoreductase activity, acting on CH-OH group of donors
GO:0016616	3.907e-02	1.718	7 AKR1D1, H6PD, HMGCR, IDH1, ME3, NSDHL, SDR42E1	24	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0004497	4.060e-02	1.289	6 CYP7B1, KMO, PAH, PCBD2, SQLE, TMEM195	18	monooxygenase activity
GO:0016714	4.623e-02	0.2864	3 PAH, PCBD2, TMEM195	4	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0016769	4.795e-02	0.9307	5 ALAS1, CCBL1, CCBL2, GPT2, TAT	13	transferase activity, transferring nitrogenous groups

Id	Pvalue	ExpCount	Count	Size	Term
04610	9.230e-05	1.976	11 C5, C8A, C8B, C8G, CPB2, F10, F2, FGB, FGG, PLAT, SERPINC1	21	Complement and coagulation cascades
01100	1.699e-02	33.21	51 ACO1, ACSL5, AKR1D1, ALAS1, ALDH2, AMDHD1, B4GALT2, BPNT1, CDO1, CPOX, CTH, DCT, DHCR24, DMGDH, GCH1, GCLM, GGPS1, GNE, GPT2, H6PD, HAL, HAO1, HGD, HMGCR, IDH1, KMO, LCLAT1, LIPC, MAN2A1, MAT1A, ME3, NADK, NSDHL, OTC, PAFAH2, PAH, PANK1, PAPSS2, PEMT, PLA2G12B, POLR3G, RRM2B, SARDH, SCLY, SQLE, ST3GAL2, ST3GAL5, ST6GALNAC4, TAT, TDO2, TGDS	353	Metabolic pathways
04146	4.216e-02	2.823	9 ABCD3, ACSL5, CROT, FAR1, HAO1, IDH1, PEX11A, PEX16, PEX7	30	Peroxisome

No enriched terms

No enriched terms

Entrez genes

A1CFAPOBEC1 complementation factor (ENSG00000148584), score: 0.31 ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (ENSG00000165029), score: 0.37 ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ENSG00000073734), score: 0.46 ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 2 (ENSG00000023839), score: 0.36 ABCD3ATP-binding cassette, sub-family D (ALD), member 3 (ENSG00000117528), score: 0.51 ABCG5ATP-binding cassette, sub-family G (WHITE), member 5 (ENSG00000138075), score: 0.46 ABI2abl-interactor 2 (ENSG00000138443), score: -0.42 ACBD5acyl-CoA binding domain containing 5 (ENSG00000107897), score: 0.43 ACO1aconitase 1, soluble (ENSG00000122729), score: 0.3 ACOT12acyl-CoA thioesterase 12 (ENSG00000172497), score: 0.38 ACSL5acyl-CoA synthetase long-chain family member 5 (ENSG00000197142), score: 0.37 ADAP2ArfGAP with dual PH domains 2 (ENSG00000184060), score: 0.36 ADRA1Badrenergic, alpha-1B-, receptor (ENSG00000170214), score: 0.3 AFAP1L2actin filament associated protein 1-like 2 (ENSG00000169129), score: -0.36 AIM1absent in melanoma 1 (ENSG00000112297), score: 0.29 AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase) (ENSG00000122787), score: 0.29 ALAS1aminolevulinate, delta-, synthase 1 (ENSG00000023330), score: 0.43 ALBalbumin (ENSG00000163631), score: 0.34 ALDH2aldehyde dehydrogenase 2 family (mitochondrial) (ENSG00000111275), score: 0.3 ALDH8A1aldehyde dehydrogenase 8 family, member A1 (ENSG00000118514), score: 0.3 AMBPalpha-1-microglobulin/bikunin precursor (ENSG00000106927), score: 0.32 AMDHD1amidohydrolase domain containing 1 (ENSG00000139344), score: 0.34 AMMECR1LAMME chromosomal region gene 1-like (ENSG00000144233), score: 0.42 ANKS4Bankyrin repeat and sterile alpha motif domain containing 4B (ENSG00000175311), score: 0.34 AP3M1adaptor-related protein complex 3, mu 1 subunit (ENSG00000185009), score: 0.34 APBA3amyloid beta (A4) precursor protein-binding, family A, member 3 (ENSG00000011132), score: 0.31 AQP8aquaporin 8 (ENSG00000103375), score: 0.56 ARCN1archain 1 (ENSG00000095139), score: 0.35 ARHGAP42Rho GTPase activating protein 42 (ENSG00000165895), score: 0.43 ARID5BAT rich interactive domain 5B (MRF1-like) (ENSG00000150347), score: 0.31 ARV1ARV1 homolog (S. cerevisiae) (ENSG00000173409), score: -0.35 ASPGasparaginase homolog (S. cerevisiae) (ENSG00000166183), score: 0.31 ATG5ATG5 autophagy related 5 homolog (S. cerevisiae) (ENSG00000057663), score: 0.32 ATL2atlastin GTPase 2 (ENSG00000119787), score: 0.43 ATP13A3ATPase type 13A3 (ENSG00000133657), score: 0.3 ATP8B1ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ENSG00000081923), score: 0.3 ATPAF1ATP synthase mitochondrial F1 complex assembly factor 1 (ENSG00000123472), score: -0.4 ATPIF1ATPase inhibitory factor 1 (ENSG00000130770), score: -0.39 AVPR1Aarginine vasopressin receptor 1A (ENSG00000166148), score: 0.35 B4GALT2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 (ENSG00000117411), score: -0.55 BACH1BTB and CNC homology 1, basic leucine zipper transcription factor 1 (ENSG00000156273), score: 0.32 BBS2Bardet-Biedl syndrome 2 (ENSG00000125124), score: -0.59 BPHLbiphenyl hydrolase-like (serine hydrolase) (ENSG00000137274), score: 0.3 BPNT13'(2'), 5'-bisphosphate nucleotidase 1 (ENSG00000162813), score: 0.34 BRAPBRCA1 associated protein (ENSG00000089234), score: 0.33 C10orf46chromosome 10 open reading frame 46 (ENSG00000151893), score: 0.3 C11orf54chromosome 11 open reading frame 54 (ENSG00000182919), score: 0.29 C12orf72chromosome 12 open reading frame 72 (ENSG00000139160), score: 0.51 C13orf15chromosome 13 open reading frame 15 (ENSG00000102760), score: -0.4 C16orf48chromosome 16 open reading frame 48 (ENSG00000124074), score: -0.37 C16orf70chromosome 16 open reading frame 70 (ENSG00000125149), score: 0.42 C19orf12chromosome 19 open reading frame 12 (ENSG00000131943), score: 0.4 C1orf91chromosome 1 open reading frame 91 (ENSG00000160055), score: 0.36 C2CD2C2 calcium-dependent domain containing 2 (ENSG00000157617), score: 0.49 C5complement component 5 (ENSG00000106804), score: 0.38 C5orf33chromosome 5 open reading frame 33 (ENSG00000152620), score: 0.35 C6orf106chromosome 6 open reading frame 106 (ENSG00000196821), score: 0.31 C7orf23chromosome 7 open reading frame 23 (ENSG00000135185), score: 0.55 C7orf58chromosome 7 open reading frame 58 (ENSG00000106034), score: 0.33 C8Acomplement component 8, alpha polypeptide (ENSG00000157131), score: 0.34 C8Bcomplement component 8, beta polypeptide (ENSG00000021852), score: 0.34 C8Gcomplement component 8, gamma polypeptide (ENSG00000176919), score: 0.33 C9orf150chromosome 9 open reading frame 150 (ENSG00000153714), score: 0.37 CA1carbonic anhydrase I (ENSG00000133742), score: 0.44 CASP8caspase 8, apoptosis-related cysteine peptidase (ENSG00000064012), score: 0.37 CCBL1cysteine conjugate-beta lyase, cytoplasmic (ENSG00000171097), score: 0.3 CCBL2cysteine conjugate-beta lyase 2 (ENSG00000137944), score: 0.52 CCDC117coiled-coil domain containing 117 (ENSG00000159873), score: 0.33 CCDC92coiled-coil domain containing 92 (ENSG00000119242), score: -0.42 CCRL1chemokine (C-C motif) receptor-like 1 (ENSG00000129048), score: 0.51 CDK8cyclin-dependent kinase 8 (ENSG00000132964), score: 0.47 CDO1cysteine dioxygenase, type I (ENSG00000129596), score: 0.34 CGRRF1cell growth regulator with ring finger domain 1 (ENSG00000100532), score: 0.38 CHAC2ChaC, cation transport regulator homolog 2 (E. coli) (ENSG00000143942), score: 0.31 CHUKconserved helix-loop-helix ubiquitous kinase (ENSG00000213341), score: 0.43 CIB3calcium and integrin binding family member 3 (ENSG00000141977), score: 0.52 CKAP5cytoskeleton associated protein 5 (ENSG00000175216), score: -0.36 CLCN6chloride channel 6 (ENSG00000011021), score: -0.36 CLDN14claudin 14 (ENSG00000159261), score: 0.33 CLEC3BC-type lectin domain family 3, member B (ENSG00000163815), score: -0.4 CLIP4CAP-GLY domain containing linker protein family, member 4 (ENSG00000115295), score: -0.38 CLSTN1calsyntenin 1 (ENSG00000171603), score: -0.36 CMTM6CKLF-like MARVEL transmembrane domain containing 6 (ENSG00000091317), score: 0.3 CMTM8CKLF-like MARVEL transmembrane domain containing 8 (ENSG00000170293), score: 0.33 CNR2cannabinoid receptor 2 (macrophage) (ENSG00000188822), score: 0.79 COL10A1collagen, type X, alpha 1 (ENSG00000123500), score: 0.37 COPB2coatomer protein complex, subunit beta 2 (beta prime) (ENSG00000184432), score: 0.36 CPB2carboxypeptidase B2 (plasma) (ENSG00000080618), score: 0.36 CPOXcoproporphyrinogen oxidase (ENSG00000080819), score: 0.41 CPSF4Lcleavage and polyadenylation specific factor 4-like (ENSG00000187959), score: 0.3 CREB3L3cAMP responsive element binding protein 3-like 3 (ENSG00000060566), score: 0.39 CREG1cellular repressor of E1A-stimulated genes 1 (ENSG00000143162), score: 0.34 CROTcarnitine O-octanoyltransferase (ENSG00000005469), score: 0.45 CTHcystathionase (cystathionine gamma-lyase) (ENSG00000116761), score: 0.33 CTSOcathepsin O (ENSG00000151792), score: 0.3 CYP7B1cytochrome P450, family 7, subfamily B, polypeptide 1 (ENSG00000172817), score: 0.46 DARSaspartyl-tRNA synthetase (ENSG00000115866), score: 0.32 DCLRE1ADNA cross-link repair 1A (ENSG00000198924), score: 0.42 DCTdopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) (ENSG00000080166), score: 0.41 DEPDC6DEP domain containing 6 (ENSG00000155792), score: 0.34 DERL1Der1-like domain family, member 1 (ENSG00000136986), score: 0.33 DERL2Der1-like domain family, member 2 (ENSG00000072849), score: 0.42 DHCR2424-dehydrocholesterol reductase (ENSG00000116133), score: 0.33 DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila) (ENSG00000160305), score: -0.45 DLEC1deleted in lung and esophageal cancer 1 (ENSG00000008226), score: 0.35 DMGDHdimethylglycine dehydrogenase (ENSG00000132837), score: 0.35 DNAJC22DnaJ (Hsp40) homolog, subfamily C, member 22 (ENSG00000178401), score: 0.39 DNAJC3DnaJ (Hsp40) homolog, subfamily C, member 3 (ENSG00000102580), score: 0.44 DNTTdeoxynucleotidyltransferase, terminal (ENSG00000107447), score: 0.62 DPP4dipeptidyl-peptidase 4 (ENSG00000197635), score: 0.29 DPYSL3dihydropyrimidinase-like 3 (ENSG00000113657), score: -0.39 DSG2desmoglein 2 (ENSG00000046604), score: 0.32 DUSP14dual specificity phosphatase 14 (ENSG00000161326), score: -0.37 DYNC2LI1dynein, cytoplasmic 2, light intermediate chain 1 (ENSG00000138036), score: -0.37 EDEM1ER degradation enhancer, mannosidase alpha-like 1 (ENSG00000134109), score: 0.37 EDEM2ER degradation enhancer, mannosidase alpha-like 2 (ENSG00000088298), score: 0.31 EGFRepidermal growth factor receptor (ENSG00000146648), score: 0.46 ELK4ELK4, ETS-domain protein (SRF accessory protein 1) (ENSG00000158711), score: 0.36 EPB41L4Berythrocyte membrane protein band 4.1 like 4B (ENSG00000095203), score: 0.31 ERN1endoplasmic reticulum to nucleus signaling 1 (ENSG00000178607), score: 0.44 EVI5ecotropic viral integration site 5 (ENSG00000067208), score: 0.35 F10coagulation factor X (ENSG00000126218), score: 0.37 F2coagulation factor II (thrombin) (ENSG00000180210), score: 0.35 FABP2fatty acid binding protein 2, intestinal (ENSG00000145384), score: 1 FAM105Bfamily with sequence similarity 105, member B (ENSG00000154124), score: 0.38 FAM134Cfamily with sequence similarity 134, member C (ENSG00000141699), score: 0.3 FAM160B1family with sequence similarity 160, member B1 (ENSG00000151553), score: 0.41 FAM175Bfamily with sequence similarity 175, member B (ENSG00000165660), score: 0.33 FAM176Afamily with sequence similarity 176, member A (ENSG00000115363), score: 0.31 FAM59Afamily with sequence similarity 59, member A (ENSG00000141441), score: 0.37 FAM69Bfamily with sequence similarity 69, member B (ENSG00000165716), score: -0.38 FAM82A1family with sequence similarity 82, member A1 (ENSG00000115841), score: 0.33 FAR1fatty acyl CoA reductase 1 (ENSG00000197601), score: -0.41 FBXL4F-box and leucine-rich repeat protein 4 (ENSG00000112234), score: 0.31 FBXL5F-box and leucine-rich repeat protein 5 (ENSG00000118564), score: -0.37 FBXO3F-box protein 3 (ENSG00000110429), score: 0.32 FDXRferredoxin reductase (ENSG00000161513), score: 0.35 FETUBfetuin B (ENSG00000090512), score: 0.39 FGBfibrinogen beta chain (ENSG00000171564), score: 0.32 FGD6FYVE, RhoGEF and PH domain containing 6 (ENSG00000180263), score: 0.41 FGGfibrinogen gamma chain (ENSG00000171557), score: 0.32 FN1fibronectin 1 (ENSG00000115414), score: 0.32 FUBP1far upstream element (FUSE) binding protein 1 (ENSG00000162613), score: -0.38 GCH1GTP cyclohydrolase 1 (ENSG00000131979), score: 0.35 GCLMglutamate-cysteine ligase, modifier subunit (ENSG00000023909), score: 0.32 GDF2growth differentiation factor 2 (ENSG00000128802), score: 0.34 GFRA1GDNF family receptor alpha 1 (ENSG00000151892), score: 0.46 GGPS1geranylgeranyl diphosphate synthase 1 (ENSG00000152904), score: -0.43 GJB1gap junction protein, beta 1, 32kDa (ENSG00000169562), score: 0.3 GJB2gap junction protein, beta 2, 26kDa (ENSG00000165474), score: 0.49 GLO1glyoxalase I (ENSG00000124767), score: 0.33 GLT25D1glycosyltransferase 25 domain containing 1 (ENSG00000130309), score: 0.3 GM2AGM2 ganglioside activator (ENSG00000196743), score: 0.36 GMPRguanosine monophosphate reductase (ENSG00000137198), score: -0.38 GNAI1guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (ENSG00000127955), score: -0.47 GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (ENSG00000159921), score: 0.51 GNMTglycine N-methyltransferase (ENSG00000124713), score: 0.44 GPLD1glycosylphosphatidylinositol specific phospholipase D1 (ENSG00000112293), score: 0.47 GPR180G protein-coupled receptor 180 (ENSG00000152749), score: 0.4 GPR97G protein-coupled receptor 97 (ENSG00000182885), score: 0.35 GPT2glutamic pyruvate transaminase (alanine aminotransferase) 2 (ENSG00000166123), score: 0.41 GRPEL2GrpE-like 2, mitochondrial (E. coli) (ENSG00000164284), score: 0.32 GUCA1Aguanylate cyclase activator 1A (retina) (ENSG00000048545), score: 0.29 GXYLT1glucoside xylosyltransferase 1 (ENSG00000151233), score: 0.3 H1FXH1 histone family, member X (ENSG00000184897), score: -0.53 H6PDhexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) (ENSG00000049239), score: 0.44 HALhistidine ammonia-lyase (ENSG00000084110), score: 0.44 HAO1hydroxyacid oxidase (glycolate oxidase) 1 (ENSG00000101323), score: 0.35 HBP1HMG-box transcription factor 1 (ENSG00000105856), score: 0.3 HDDC2HD domain containing 2 (ENSG00000111906), score: -0.36 HEBP1heme binding protein 1 (ENSG00000013583), score: 0.32 HELBhelicase (DNA) B (ENSG00000127311), score: 0.29 HERPUD1homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (ENSG00000051108), score: 0.4 HGDhomogentisate 1,2-dioxygenase (ENSG00000113924), score: 0.3 HMGCR3-hydroxy-3-methylglutaryl-CoA reductase (ENSG00000113161), score: 0.38 HNF4Ahepatocyte nuclear factor 4, alpha (ENSG00000101076), score: 0.32 HNRNPRheterogeneous nuclear ribonucleoprotein R (ENSG00000125944), score: -0.45 HPXhemopexin (ENSG00000110169), score: 0.32 HRGhistidine-rich glycoprotein (ENSG00000113905), score: 0.3 HTRA1HtrA serine peptidase 1 (ENSG00000166033), score: -0.47 IAH1isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) (ENSG00000134330), score: 0.32 ICOSinducible T-cell co-stimulator (ENSG00000163600), score: 0.37 IDH1isocitrate dehydrogenase 1 (NADP+), soluble (ENSG00000138413), score: 0.3 IFFO1intermediate filament family orphan 1 (ENSG00000010295), score: -0.45 IFIH1interferon induced with helicase C domain 1 (ENSG00000115267), score: 0.3 IFT57intraflagellar transport 57 homolog (Chlamydomonas) (ENSG00000114446), score: -0.42 IGF1insulin-like growth factor 1 (somatomedin C) (ENSG00000017427), score: 0.43 IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (ENSG00000143466), score: 0.36 IL1RAPinterleukin 1 receptor accessory protein (ENSG00000196083), score: 0.42 ITCHitchy E3 ubiquitin protein ligase homolog (mouse) (ENSG00000078747), score: 0.34 ITM2Bintegral membrane protein 2B (ENSG00000136156), score: 0.31 IYDiodotyrosine deiodinase (ENSG00000009765), score: 0.35 JAG2jagged 2 (ENSG00000184916), score: -0.38 JAM3junctional adhesion molecule 3 (ENSG00000166086), score: -0.45 KCTD1potassium channel tetramerisation domain containing 1 (ENSG00000134504), score: -0.38 KCTD5potassium channel tetramerisation domain containing 5 (ENSG00000167977), score: -0.36 KIAA1370KIAA1370 (ENSG00000047346), score: 0.3 KIAA2018KIAA2018 (ENSG00000176542), score: 0.33 KIFAP3kinesin-associated protein 3 (ENSG00000075945), score: -0.37 KLBklotho beta (ENSG00000134962), score: 0.42 KLF15Kruppel-like factor 15 (ENSG00000163884), score: 0.31 KLHDC2kelch domain containing 2 (ENSG00000165516), score: -0.37 KMOkynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (ENSG00000117009), score: 0.32 LAMP2lysosomal-associated membrane protein 2 (ENSG00000005893), score: 0.37 LARP4BLa ribonucleoprotein domain family, member 4B (ENSG00000107929), score: 0.38 LCLAT1lysocardiolipin acyltransferase 1 (ENSG00000172954), score: 0.33 LECT1leukocyte cell derived chemotaxin 1 (ENSG00000136110), score: 0.3 LECT2leukocyte cell-derived chemotaxin 2 (ENSG00000145826), score: 0.4 LIFRleukemia inhibitory factor receptor alpha (ENSG00000113594), score: 0.6 LIPClipase, hepatic (ENSG00000166035), score: 0.42 LOC100292202similar to solute carrier family 25, member 25 (ENSG00000148339), score: 0.33 LPGAT1lysophosphatidylglycerol acyltransferase 1 (ENSG00000123684), score: 0.37 LPIN1lipin 1 (ENSG00000134324), score: 0.41 LPIN2lipin 2 (ENSG00000101577), score: 0.33 LRIT2leucine-rich repeat, immunoglobulin-like and transmembrane domains 2 (ENSG00000204033), score: 0.57 LYSMD3LysM, putative peptidoglycan-binding, domain containing 3 (ENSG00000176018), score: 0.29 MAN2A1mannosidase, alpha, class 2A, member 1 (ENSG00000112893), score: 0.39 MAP1Dmethionine aminopeptidase 1D (ENSG00000172878), score: 0.38 MARCH5membrane-associated ring finger (C3HC4) 5 (ENSG00000198060), score: 0.44 MAT1Amethionine adenosyltransferase I, alpha (ENSG00000151224), score: 0.39 MBIPMAP3K12 binding inhibitory protein 1 (ENSG00000151332), score: -0.45 MCM10minichromosome maintenance complex component 10 (ENSG00000065328), score: 0.62 MCRS1microspherule protein 1 (ENSG00000187778), score: -0.5 ME3malic enzyme 3, NADP(+)-dependent, mitochondrial (ENSG00000151376), score: -0.4 MEAF6MYST/Esa1-associated factor 6 (ENSG00000163875), score: -0.41 MED8mediator complex subunit 8 (ENSG00000159479), score: 0.3 MIA3melanoma inhibitory activity family, member 3 (ENSG00000154305), score: 0.51 MINPP1multiple inositol-polyphosphate phosphatase 1 (ENSG00000107789), score: 0.31 MIPOL1mirror-image polydactyly 1 (ENSG00000151338), score: 0.4 MOCOSmolybdenum cofactor sulfurase (ENSG00000075643), score: 0.37 MOSPD2motile sperm domain containing 2 (ENSG00000130150), score: 0.31 MPZL3myelin protein zero-like 3 (ENSG00000160588), score: 0.3 MRASmuscle RAS oncogene homolog (ENSG00000158186), score: -0.37 MTTPmicrosomal triglyceride transfer protein (ENSG00000138823), score: 0.34 MYO1Bmyosin IB (ENSG00000128641), score: 0.29 NADKNAD kinase (ENSG00000008130), score: 0.36 NAPEPLDN-acyl phosphatidylethanolamine phospholipase D (ENSG00000161048), score: -0.44 NECAB3N-terminal EF-hand calcium binding protein 3 (ENSG00000125967), score: -0.38 NEDD4neural precursor cell expressed, developmentally down-regulated 4 (ENSG00000069869), score: 0.37 NHLRC2NHL repeat containing 2 (ENSG00000196865), score: 0.33 NIPAL1NIPA-like domain containing 1 (ENSG00000163293), score: 0.39 NPC1Niemann-Pick disease, type C1 (ENSG00000141458), score: 0.36 NR1H4nuclear receptor subfamily 1, group H, member 4 (ENSG00000012504), score: 0.34 NR5A2nuclear receptor subfamily 5, group A, member 2 (ENSG00000116833), score: 0.37 NSDHLNAD(P) dependent steroid dehydrogenase-like (ENSG00000147383), score: 0.34 NSL1NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) (ENSG00000117697), score: -0.4 NSUN2NOP2/Sun domain family, member 2 (ENSG00000037474), score: 0.32 ONECUT1one cut homeobox 1 (ENSG00000169856), score: 0.41 OSGIN2oxidative stress induced growth inhibitor family member 2 (ENSG00000164823), score: -0.37 OTCornithine carbamoyltransferase (ENSG00000036473), score: 0.44 P4HTMprolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) (ENSG00000178467), score: -0.44 PAFAH2platelet-activating factor acetylhydrolase 2, 40kDa (ENSG00000158006), score: 0.32 PAHphenylalanine hydroxylase (ENSG00000171759), score: 0.34 PAK1IP1PAK1 interacting protein 1 (ENSG00000111845), score: 0.36 PANK1pantothenate kinase 1 (ENSG00000152782), score: 0.36 PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2 (ENSG00000198682), score: 0.33 PAQR9progestin and adipoQ receptor family member IX (ENSG00000188582), score: 0.3 PARD3par-3 partitioning defective 3 homolog (C. elegans) (ENSG00000148498), score: 0.35 PCBD2pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 (ENSG00000132570), score: 0.3 PCSK9proprotein convertase subtilisin/kexin type 9 (ENSG00000169174), score: 0.33 PCTPphosphatidylcholine transfer protein (ENSG00000141179), score: 0.32 PDE3Bphosphodiesterase 3B, cGMP-inhibited (ENSG00000152270), score: 0.3 PDIA6protein disulfide isomerase family A, member 6 (ENSG00000143870), score: 0.32 PDP1pyruvate dehyrogenase phosphatase catalytic subunit 1 (ENSG00000164951), score: -0.37 PEMTphosphatidylethanolamine N-methyltransferase (ENSG00000133027), score: 0.3 PEX11Aperoxisomal biogenesis factor 11 alpha (ENSG00000166821), score: 0.41 PEX16peroxisomal biogenesis factor 16 (ENSG00000121680), score: 0.42 PEX7peroxisomal biogenesis factor 7 (ENSG00000112357), score: 0.33 PGAP3post-GPI attachment to proteins 3 (ENSG00000161395), score: -0.43 PIK3IP1phosphoinositide-3-kinase interacting protein 1 (ENSG00000100100), score: -0.48 PLA2G12Bphospholipase A2, group XIIB (ENSG00000138308), score: 0.3 PLAAphospholipase A2-activating protein (ENSG00000137055), score: 0.3 PLATplasminogen activator, tissue (ENSG00000104368), score: -0.38 PLK3polo-like kinase 3 (ENSG00000173846), score: 0.56 PM20D1peptidase M20 domain containing 1 (ENSG00000162877), score: 0.33 POLR3Gpolymerase (RNA) III (DNA directed) polypeptide G (32kD) (ENSG00000113356), score: 0.35 PPM1Bprotein phosphatase, Mg2+/Mn2+ dependent, 1B (ENSG00000138032), score: 0.3 PPP1R15Bprotein phosphatase 1, regulatory (inhibitor) subunit 15B (ENSG00000158615), score: 0.47 PPP1R3Dprotein phosphatase 1, regulatory (inhibitor) subunit 3D (ENSG00000132825), score: -0.38 PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha (ENSG00000066027), score: 0.4 PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit (ENSG00000131791), score: -0.39 PRKD1protein kinase D1 (ENSG00000184304), score: -0.38 PRKD3protein kinase D3 (ENSG00000115825), score: 0.53 PRLRprolactin receptor (ENSG00000113494), score: 0.49 PROZprotein Z, vitamin K-dependent plasma glycoprotein (ENSG00000126231), score: 0.36 PSEN2presenilin 2 (Alzheimer disease 4) (ENSG00000143801), score: 0.44 PSMA4proteasome (prosome, macropain) subunit, alpha type, 4 (ENSG00000041357), score: 0.36 PSMD12proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 (ENSG00000197170), score: 0.35 PSTPIP2proline-serine-threonine phosphatase interacting protein 2 (ENSG00000152229), score: 0.34 PUS10pseudouridylate synthase 10 (ENSG00000162927), score: 0.29 PYGLphosphorylase, glycogen, liver (ENSG00000100504), score: 0.35 QSOX1quiescin Q6 sulfhydryl oxidase 1 (ENSG00000116260), score: 0.44 RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (ENSG00000173166), score: 0.34 RCN2reticulocalbin 2, EF-hand calcium binding domain (ENSG00000117906), score: -0.37 RDXradixin (ENSG00000137710), score: 0.35 RGNregucalcin (senescence marker protein-30) (ENSG00000130988), score: 0.33 RNF34ring finger protein 34 (ENSG00000170633), score: -0.44 RRM2Bribonucleotide reductase M2 B (TP53 inducible) (ENSG00000048392), score: -0.37 RXRAretinoid X receptor, alpha (ENSG00000186350), score: 0.36 SAR1BSAR1 homolog B (S. cerevisiae) (ENSG00000152700), score: 0.3 SARDHsarcosine dehydrogenase (ENSG00000123453), score: 0.4 SCCPDHsaccharopine dehydrogenase (putative) (ENSG00000143653), score: -0.59 SCLYselenocysteine lyase (ENSG00000132330), score: 0.33 SDR42E1short chain dehydrogenase/reductase family 42E, member 1 (ENSG00000184860), score: 0.53 SEC16BSEC16 homolog B (S. cerevisiae) (ENSG00000120341), score: 0.33 SEC24DSEC24 family, member D (S. cerevisiae) (ENSG00000150961), score: 0.32 SEC63SEC63 homolog (S. cerevisiae) (ENSG00000025796), score: 0.36 SEP1515 kDa selenoprotein (ENSG00000183291), score: 0.32 SEPSECSSep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase (ENSG00000109618), score: 0.39 SEPT6septin 6 (ENSG00000125354), score: -0.43 SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 (ENSG00000140093), score: 0.35 SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 1 (ENSG00000117601), score: 0.34 SESTD1SEC14 and spectrin domains 1 (ENSG00000187231), score: -0.4 SGCBsarcoglycan, beta (43kDa dystrophin-associated glycoprotein) (ENSG00000163069), score: -0.44 SH3BP4SH3-domain binding protein 4 (ENSG00000130147), score: -0.38 SIRT3sirtuin 3 (ENSG00000142082), score: 0.34 SLC10A2solute carrier family 10 (sodium/bile acid cotransporter family), member 2 (ENSG00000125255), score: 0.4 SLC16A10solute carrier family 16, member 10 (aromatic amino acid transporter) (ENSG00000112394), score: 0.44 SLC16A12solute carrier family 16, member 12 (monocarboxylic acid transporter 12) (ENSG00000152779), score: 0.31 SLC17A8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 (ENSG00000179520), score: 0.74 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (ENSG00000117479), score: 0.43 SLC25A16solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 (ENSG00000122912), score: 0.33 SLC25A47solute carrier family 25, member 47 (ENSG00000140107), score: 0.4 SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2 (ENSG00000163581), score: 0.32 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.33 SLC35D1solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1 (ENSG00000116704), score: 0.41 SLC38A4solute carrier family 38, member 4 (ENSG00000139209), score: 0.43 SLC39A6solute carrier family 39 (zinc transporter), member 6 (ENSG00000141424), score: -0.39 SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (ENSG00000003989), score: 0.36 SLC7A6solute carrier family 7 (cationic amino acid transporter, y+ system), member 6 (ENSG00000103064), score: -0.49 SLCO2B1solute carrier organic anion transporter family, member 2B1 (ENSG00000137491), score: 0.34 SLIT3slit homolog 3 (Drosophila) (ENSG00000184347), score: -0.42 SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (ENSG00000102038), score: -0.44 SMEK1SMEK homolog 1, suppressor of mek1 (Dictyostelium) (ENSG00000100796), score: 0.33 SMYD4SET and MYND domain containing 4 (ENSG00000186532), score: -0.41 SNNstannin (ENSG00000184602), score: -0.4 SNTG2syntrophin, gamma 2 (ENSG00000172554), score: 0.47 SNX17sorting nexin 17 (ENSG00000115234), score: -0.41 SPIRE1spire homolog 1 (Drosophila) (ENSG00000134278), score: -0.37 SPP2secreted phosphoprotein 2, 24kDa (ENSG00000072080), score: 0.32 SQLEsqualene epoxidase (ENSG00000104549), score: 0.34 SSPNsarcospan (Kras oncogene-associated gene) (ENSG00000123096), score: 0.4 ST3GAL2ST3 beta-galactoside alpha-2,3-sialyltransferase 2 (ENSG00000157350), score: -0.36 ST3GAL5ST3 beta-galactoside alpha-2,3-sialyltransferase 5 (ENSG00000115525), score: 0.42 ST6GALNAC4ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 (ENSG00000136840), score: -0.36 STARD5StAR-related lipid transfer (START) domain containing 5 (ENSG00000172345), score: 0.38 SUN1Sad1 and UNC84 domain containing 1 (ENSG00000164828), score: -0.43 TAPT1transmembrane anterior posterior transformation 1 (ENSG00000169762), score: 0.36 TARSthreonyl-tRNA synthetase (ENSG00000113407), score: 0.39 TATtyrosine aminotransferase (ENSG00000198650), score: 0.42 TBC1D15TBC1 domain family, member 15 (ENSG00000121749), score: 0.31 TBCELtubulin folding cofactor E-like (ENSG00000154114), score: 0.33 TDO2tryptophan 2,3-dioxygenase (ENSG00000151790), score: 0.42 TECtec protein tyrosine kinase (ENSG00000135605), score: 0.31 TERTtelomerase reverse transcriptase (ENSG00000164362), score: 0.37 TGDSTDP-glucose 4,6-dehydratase (ENSG00000088451), score: 0.4 TGFBRAP1transforming growth factor, beta receptor associated protein 1 (ENSG00000135966), score: 0.31 TM2D2TM2 domain containing 2 (ENSG00000169490), score: 0.3 TM4SF4transmembrane 4 L six family member 4 (ENSG00000169903), score: 0.35 TM9SF2transmembrane 9 superfamily member 2 (ENSG00000125304), score: 0.29 TMEM106Btransmembrane protein 106B (ENSG00000106460), score: 0.32 TMEM135transmembrane protein 135 (ENSG00000166575), score: 0.36 TMEM195transmembrane protein 195 (ENSG00000187546), score: 0.42 TMEM20transmembrane protein 20 (ENSG00000176273), score: 0.39 TMEM231transmembrane protein 231 (ENSG00000205084), score: -0.39 TMEM56transmembrane protein 56 (ENSG00000152078), score: 0.36 TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) (ENSG00000154174), score: 0.38 TOR1Atorsin family 1, member A (torsin A) (ENSG00000136827), score: 0.4 TRABDTraB domain containing (ENSG00000170638), score: 0.3 TRIB2tribbles homolog 2 (Drosophila) (ENSG00000071575), score: -0.4 TSPAN3tetraspanin 3 (ENSG00000140391), score: -0.74 TSR1TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) (ENSG00000167721), score: 0.35 TTC36tetratricopeptide repeat domain 36 (ENSG00000172425), score: 0.32 TTC39Ctetratricopeptide repeat domain 39C (ENSG00000168234), score: 0.49 TTPAtocopherol (alpha) transfer protein (ENSG00000137561), score: 0.41 TULP3tubby like protein 3 (ENSG00000078246), score: -0.44 TXNDC15thioredoxin domain containing 15 (ENSG00000113621), score: 0.37 TXNDC9thioredoxin domain containing 9 (ENSG00000115514), score: 0.3 TXNRD1thioredoxin reductase 1 (ENSG00000198431), score: 0.3 TYW3tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) (ENSG00000162623), score: -0.45 UBR2ubiquitin protein ligase E3 component n-recognin 2 (ENSG00000024048), score: 0.4 UBTD2ubiquitin domain containing 2 (ENSG00000168246), score: -0.38 USP20ubiquitin specific peptidase 20 (ENSG00000136878), score: -0.37 UVRAGUV radiation resistance associated gene (ENSG00000198382), score: 0.35 WDR36WD repeat domain 36 (ENSG00000134987), score: 0.35 WDR89WD repeat domain 89 (ENSG00000140006), score: 0.37 WRBtryptophan rich basic protein (ENSG00000182093), score: -0.4 XKR9XK, Kell blood group complex subunit-related family, member 9 (ENSG00000221947), score: 0.49 ZAP70zeta-chain (TCR) associated protein kinase 70kDa (ENSG00000115085), score: 0.44 ZBTB41zinc finger and BTB domain containing 41 (ENSG00000177888), score: 0.3 ZC3H7Azinc finger CCCH-type containing 7A (ENSG00000122299), score: 0.51 ZDHHC6zinc finger, DHHC-type containing 6 (ENSG00000023041), score: 0.36 ZFYVE1zinc finger, FYVE domain containing 1 (ENSG00000165861), score: 0.32 ZNF462zinc finger protein 462 (ENSG00000148143), score: -0.39 ZNF518Bzinc finger protein 518B (ENSG00000178163), score: -0.4 ZNF750zinc finger protein 750 (ENSG00000141579), score: 0.77 ZNF827zinc finger protein 827 (ENSG00000151612), score: -0.45

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
mmu_lv_m1_ca1	mmu	lv	m	1
mmu_lv_f_ca1	mmu	lv	f	_
mmu_lv_m2_ca1	mmu	lv	m	2