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Expression data for module #187

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Under-expression is coded with green, over-expression with red color.

Help | Hide | Top The GO tree — Biological processes

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cell morphogenesis

The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form.

cell morphogenesis involved in differentiation

The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

potassium ion transport

The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

calcium ion transport

The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

cell surface receptor linked signaling pathway

Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.

G-protein coupled receptor protein signaling pathway

The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.

glutamate signaling pathway

The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

nerve-nerve synaptic transmission

The process of communication from a neuron to another neuron across a synapse.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

nervous system development

The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.

neurological system process

A organ system process carried out by any of the organs or tissues of neurological system.

axonogenesis

Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

brain development

The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

learning or memory

The acquisition and processing of information and/or the storage and retrieval of this information over time.

memory

The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

di-, tri-valent inorganic cation transport

The directed movement of inorganic cations with a valency of two or three into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

cellular component organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

telencephalon development

The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.

limbic system development

The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory.

central nervous system neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.

central nervous system neuron development

The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.

central nervous system neuron axonogenesis

Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.

neurogenesis

Generation of cells within the nervous system.

signaling pathway

The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

signaling

The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.

signal transmission

The process whereby a signal is released and/or conveyed from one location to another.

cell projection organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.

neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron.

forebrain development

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).

neuron projection development

The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

regulation of neurological system process

Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

cellular component morphogenesis

The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.

cell part morphogenesis

The process by which the anatomical structures of a cell part are generated and organized. Morphogenesis pertains to the creation of form.

synaptic transmission, glutamatergic

The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

extracellular structure organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

regulation of synaptic plasticity

A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.

regulation of neuronal synaptic plasticity

A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.

regulation of long-term neuronal synaptic plasticity

A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

neuron development

The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

cell morphogenesis involved in neuron differentiation

The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.

generation of neurons

The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

neuron projection morphogenesis

The process by which the anatomical structures of a neuron projection are generated and organized. Morphogenesis pertains to the creation of form. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cell projection morphogenesis

The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

epithelial cell proliferation

The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.

regulation of epithelial cell proliferation

Any process that modulates the frequency, rate or extent of epithelial cell proliferation.

positive regulation of epithelial cell proliferation

Any process that activates or increases the rate or extent of epithelial cell proliferation.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of behavior

Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

regulation of synapse structure and activity

Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

regulation of synaptic transmission

Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

regulation of synapse organization

Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

synapse organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

cognition

The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

regulation of cellular component organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of transmission of nerve impulse

Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.

positive regulation of epithelial cell proliferation involved in wound healing

Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

divalent metal ion transport

The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

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cell projection organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.

extracellular structure organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.

signaling process

Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

cellular developmental process

A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cellular component organization

Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

regulation of multicellular organismal process

Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.

regulation of response to stimulus

Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

regulation of epithelial cell proliferation

Any process that modulates the frequency, rate or extent of epithelial cell proliferation.

positive regulation of epithelial cell proliferation

Any process that activates or increases the rate or extent of epithelial cell proliferation.

cell-cell signaling

Any process that mediates the transfer of information from one cell to another.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

cellular component morphogenesis

The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.

regulation of cell communication

Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of synapse organization

Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

regulation of system process

Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.

cellular component morphogenesis

The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.

anatomical structure morphogenesis

The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of behavior

Any process that modulates the frequency, rate or extent of behavior, the specific actions or reactions of an organism in response to external or internal stimuli.

positive regulation of epithelial cell proliferation

Any process that activates or increases the rate or extent of epithelial cell proliferation.

synaptic transmission

The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

regulation of transmission of nerve impulse

Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.

neuron projection morphogenesis

The process by which the anatomical structures of a neuron projection are generated and organized. Morphogenesis pertains to the creation of form. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

regulation of synapse organization

Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

cell development

The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.

cell morphogenesis involved in differentiation

The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.

cell projection morphogenesis

The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.

cell projection morphogenesis

The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.

regulation of synapse structure and activity

Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

transmission of nerve impulse

The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.

regulation of neurological system process

Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

telencephalon development

The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.

limbic system development

The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory.

regulation of synapse organization

Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).

regulation of synaptic transmission

Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

neuron development

The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.

neuron projection development

The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).

cell morphogenesis involved in neuron differentiation

The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.

regulation of synaptic plasticity

A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.

regulation of transmission of nerve impulse

Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.

learning or memory

The acquisition and processing of information and/or the storage and retrieval of this information over time.

central nervous system development

The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.

neurogenesis

Generation of cells within the nervous system.

brain development

The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).

central nervous system neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.

forebrain development

The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).

positive regulation of epithelial cell proliferation involved in wound healing

Any process that activates or increases the rate or extent of epithelial cell proliferation, contributing to the restoration of integrity to a damaged tissue following an injury.

neuron differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a neuron.

central nervous system neuron development

The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.

axonogenesis

Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.

central nervous system neuron axonogenesis

Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.

potassium ion transport

The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

divalent metal ion transport

The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

Help | Hide | Top The GO tree — Cellular Components

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plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoskeleton

Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

postsynaptic density

The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.

cell junction

A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

external encapsulating structure

A structure that lies outside the plasma membrane and surrounds the entire cell.

axon

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

dendrite

A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

asymmetric synapse

A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

axon part

A part of an axon, a cell projection of a neuron.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

cation channel complex

An ion channel complex through which cations pass.

potassium channel complex

An ion channel complex through which potassium ions pass.

chloride channel complex

An ion channel complex through which chloride ions pass.

presynaptic membrane

A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

neuron projection

A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.

neuronal cell body

The portion of a neuron that includes the nucleus, but excludes all cell projections such as axons and dendrites.

dendritic spine

Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

axon terminus

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.

cell body

The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.

neuron projection terminus

The specialized, terminal region of a neuron projection such as an axon or a dendrite.

neuron spine

A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

synapse

The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

synapse part

Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.

intracellular non-membrane-bounded organelle

Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

presynaptic membrane

A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

postsynaptic membrane

A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

postsynaptic density

The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

neuron projection terminus

The specialized, terminal region of a neuron projection such as an axon or a dendrite.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

axon terminus

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.

cytoskeletal part

Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.

axon part

A part of an axon, a cell projection of a neuron.

dendritic spine

Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.

dendritic spine

Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.

ion channel complex

A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

voltage-gated potassium channel complex

A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.

Help | Hide | Top The GO tree — Molecular Function

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molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

inositol or phosphatidylinositol phosphodiesterase activity

NA

phosphoinositide phospholipase C activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

phospholipase activity

Catalysis of the hydrolysis of a glycerophospholipid.

phospholipase C activity

Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

G-protein coupled receptor activity

A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.

ionotropic glutamate receptor activity

Combining with glutamate to initiate a change in cell activity through the regulation of ion channels.

serotonin receptor activity

Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

extracellular ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.

excitatory extracellular ligand-gated ion channel activity

NA

extracellular-glutamate-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts.

voltage-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.

voltage-gated potassium channel activity

Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

potassium channel activity

Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

glutamate receptor activity

Combining with glutamate to initiate a change in cell activity.

phosphoric diester hydrolase activity

Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.

G-protein coupled amine receptor activity

A receptor that binds an extracellular amine and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

lipase activity

Catalysis of the hydrolysis of a lipid or phospholipid.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on ester bonds

Catalysis of the hydrolysis of any ester bond.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

voltage-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

voltage-gated cation channel activity

Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

neurotransmitter binding

Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.

phosphoric ester hydrolase activity

Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.

amine binding

Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.

serotonin binding

Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

phospholipase C activity

Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

phosphoinositide phospholipase C activity

Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

voltage-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

voltage-gated cation channel activity

Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.

voltage-gated potassium channel activity

Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.

Help | Show | Top GO BP test for over-representation

Help | Show | Top GO CC test for over-representation

Help | Show | Top GO MF test for over-representation

Help | Hide | Top KEGG Pathway test for over-representation

Id Pvalue ExpCount Count Size Term
04080 1.048e-11 7.357 33
206 Neuroactive ligand-receptor interaction
04020 7.561e-06 5.179 20
145 Calcium signaling pathway
04310 5.197e-04 4.179 15
117 Wnt signaling pathway
04720 5.197e-04 1.893 10
53 Long-term potentiation
04360 6.975e-04 3.786 14
106 Axon guidance
04540 1.187e-03 2.107 10
59 Gap junction
04971 2.301e-02 2.143 8
60 Gastric acid secretion
04730 4.643e-02 1.929 7
54 Long-term depression
05014 4.913e-02 1.464 6
41 Amyotrophic lateral sclerosis (ALS)

Help | Hide | Top miRNA test for over-representation

Id Pvalue ExpCount Count Size
miR-153 2.817e-03 21.74 46
453
miR-218 9.151e-03 26.74 51
557
miR-448 2.012e-02 20.35 41
424
miR-217 4.823e-02 8.592 22
179

Help | Hide | Top Chromosome test for over-representation

No enriched terms

Help | Hide | Top Genes

Entrez genes

ABHD12Babhydrolase domain containing 12B (ENSG00000131969), score: 0.62 ABI2abl-interactor 2 (ENSG00000138443), score: 0.59 ACBD7acyl-CoA binding domain containing 7 (ENSG00000176244), score: 0.59 ACVR2Aactivin A receptor, type IIA (ENSG00000121989), score: 0.6 ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary) (ENSG00000141433), score: 0.63 AGBL4ATP/GTP binding protein-like 4 (ENSG00000186094), score: 0.62 AK5adenylate kinase 5 (ENSG00000154027), score: 0.63 AKAP11A kinase (PRKA) anchor protein 11 (ENSG00000023516), score: 0.67 AKT1S1AKT1 substrate 1 (proline-rich) (ENSG00000204673), score: -0.6 AKT3v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) (ENSG00000117020), score: 0.64 ALKanaplastic lymphoma receptor tyrosine kinase (ENSG00000171094), score: 0.6 ALKBH7alkB, alkylation repair homolog 7 (E. coli) (ENSG00000125652), score: -0.63 ALX4ALX homeobox 4 (ENSG00000052850), score: 0.61 ANGEL2angel homolog 2 (Drosophila) (ENSG00000174606), score: 0.6 ANKMY2ankyrin repeat and MYND domain containing 2 (ENSG00000106524), score: 0.62 ANO3anoctamin 3 (ENSG00000134343), score: 0.77 ANO4anoctamin 4 (ENSG00000151572), score: 0.6 APAF1apoptotic peptidase activating factor 1 (ENSG00000120868), score: 0.72 APCadenomatous polyposis coli (ENSG00000134982), score: 0.63 ARHGAP20Rho GTPase activating protein 20 (ENSG00000137727), score: 0.64 ARHGAP26Rho GTPase activating protein 26 (ENSG00000145819), score: 0.6 ARHGAP32Rho GTPase activating protein 32 (ENSG00000134909), score: 0.7 ARNTL2aryl hydrocarbon receptor nuclear translocator-like 2 (ENSG00000029153), score: 0.64 ARPP19cAMP-regulated phosphoprotein, 19kDa (ENSG00000128989), score: 0.6 ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ENSG00000153317), score: 0.61 ASCC2activating signal cointegrator 1 complex subunit 2 (ENSG00000100325), score: -0.62 ATP13A4ATPase type 13A4 (ENSG00000127249), score: 0.72 ATP2B1ATPase, Ca++ transporting, plasma membrane 1 (ENSG00000070961), score: 0.66 ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 (ENSG00000155097), score: 0.68 ATRNL1attractin-like 1 (ENSG00000107518), score: 0.73 AVL9AVL9 homolog (S. cerevisiase) (ENSG00000105778), score: 0.62 B3GALT1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 (ENSG00000172318), score: 0.73 B3GALT5UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 (ENSG00000183778), score: 0.6 B4GALT1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (ENSG00000086062), score: -0.63 BAG3BCL2-associated athanogene 3 (ENSG00000151929), score: -0.61 BAG4BCL2-associated athanogene 4 (ENSG00000156735), score: 0.62 BCAT1branched chain amino-acid transaminase 1, cytosolic (ENSG00000060982), score: 0.71 BCL11AB-cell CLL/lymphoma 11A (zinc finger protein) (ENSG00000119866), score: 0.61 BCL11BB-cell CLL/lymphoma 11B (zinc finger protein) (ENSG00000127152), score: 0.61 BHLHB9basic helix-loop-helix domain containing, class B, 9 (ENSG00000198908), score: 0.62 BTBD11BTB (POZ) domain containing 11 (ENSG00000151136), score: 0.59 BTBD8BTB (POZ) domain containing 8 (ENSG00000189195), score: 0.75 BTBD9BTB (POZ) domain containing 9 (ENSG00000183826), score: 0.71 C11orf41chromosome 11 open reading frame 41 (ENSG00000110427), score: 0.61 C11orf87chromosome 11 open reading frame 87 (ENSG00000185742), score: 0.66 C12orf73chromosome 12 open reading frame 73 (ENSG00000204954), score: 0.6 C13orf36chromosome 13 open reading frame 36 (ENSG00000180440), score: 0.79 C2orf80chromosome 2 open reading frame 80 (ENSG00000188674), score: 0.65 C8orf46chromosome 8 open reading frame 46 (ENSG00000169085), score: 0.63 CACNG3calcium channel, voltage-dependent, gamma subunit 3 (ENSG00000006116), score: 0.67 CACNG5calcium channel, voltage-dependent, gamma subunit 5 (ENSG00000075429), score: 0.64 CADM2cell adhesion molecule 2 (ENSG00000175161), score: 0.59 CALHM3calcium homeostasis modulator 3 (ENSG00000183128), score: 0.61 CAMK2Acalcium/calmodulin-dependent protein kinase II alpha (ENSG00000070808), score: 0.61 CAND1cullin-associated and neddylation-dissociated 1 (ENSG00000111530), score: 0.61 CAPN14calpain 14 (ENSG00000214711), score: 0.63 CAPS2calcyphosine 2 (ENSG00000180881), score: 0.62 CASD1CAS1 domain containing 1 (ENSG00000127995), score: 0.61 CBLN2cerebellin 2 precursor (ENSG00000141668), score: 0.65 CBLN4cerebellin 4 precursor (ENSG00000054803), score: 0.71 CC2D1Bcoiled-coil and C2 domain containing 1B (ENSG00000154222), score: -0.61 CCDC132coiled-coil domain containing 132 (ENSG00000004766), score: 0.63 CD47CD47 molecule (ENSG00000196776), score: 0.69 CDC40cell division cycle 40 homolog (S. cerevisiae) (ENSG00000168438), score: 0.71 CDC42SE2CDC42 small effector 2 (ENSG00000158985), score: 0.73 CDH12cadherin 12, type 2 (N-cadherin 2) (ENSG00000154162), score: 0.75 CDH8cadherin 8, type 2 (ENSG00000150394), score: 0.79 CDH9cadherin 9, type 2 (T1-cadherin) (ENSG00000113100), score: 0.77 CDK14cyclin-dependent kinase 14 (ENSG00000058091), score: 0.64 CDK17cyclin-dependent kinase 17 (ENSG00000059758), score: 0.64 CDKL5cyclin-dependent kinase-like 5 (ENSG00000008086), score: 0.76 CHMchoroideremia (Rab escort protein 1) (ENSG00000188419), score: 0.62 CHRM1cholinergic receptor, muscarinic 1 (ENSG00000168539), score: 0.64 CHRM3cholinergic receptor, muscarinic 3 (ENSG00000133019), score: 0.79 CHSY3chondroitin sulfate synthase 3 (ENSG00000198108), score: 0.68 CLCA1chloride channel accessory 1 (ENSG00000016490), score: 0.83 CLEC11AC-type lectin domain family 11, member A (ENSG00000105472), score: -0.63 CLPPClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) (ENSG00000125656), score: -0.64 CLSTN2calsyntenin 2 (ENSG00000158258), score: 0.61 CLTCclathrin, heavy chain (Hc) (ENSG00000141367), score: 0.7 CNTN3contactin 3 (plasmacytoma associated) (ENSG00000113805), score: 0.77 CNTN5contactin 5 (ENSG00000149972), score: 0.87 CNTNAP5contactin associated protein-like 5 (ENSG00000155052), score: 0.83 COL24A1collagen, type XXIV, alpha 1 (ENSG00000171502), score: 0.62 CREG2cellular repressor of E1A-stimulated genes 2 (ENSG00000175874), score: 0.71 CRHcorticotropin releasing hormone (ENSG00000147571), score: 0.73 CRTC2CREB regulated transcription coactivator 2 (ENSG00000160741), score: -0.68 CSMD2CUB and Sushi multiple domains 2 (ENSG00000121904), score: 0.61 CSMD3CUB and Sushi multiple domains 3 (ENSG00000164796), score: 0.8 CSRNP3cysteine-serine-rich nuclear protein 3 (ENSG00000178662), score: 0.85 CXXC4CXXC finger 4 (ENSG00000168772), score: 0.67 DAZAP1DAZ associated protein 1 (ENSG00000071626), score: -0.59 DBX2developing brain homeobox 2 (ENSG00000185610), score: 0.66 DCCdeleted in colorectal carcinoma (ENSG00000187323), score: 0.59 DCLK1doublecortin-like kinase 1 (ENSG00000133083), score: 0.64 DCXdoublecortin (ENSG00000077279), score: 0.84 DGKBdiacylglycerol kinase, beta 90kDa (ENSG00000136267), score: 0.74 DGKIdiacylglycerol kinase, iota (ENSG00000157680), score: 0.72 DHX16DEAH (Asp-Glu-Ala-His) box polypeptide 16 (ENSG00000204560), score: -0.62 DHX33DEAH (Asp-Glu-Ala-His) box polypeptide 33 (ENSG00000005100), score: 0.61 DLGAP2discs, large (Drosophila) homolog-associated protein 2 (ENSG00000198010), score: 0.62 DLX1distal-less homeobox 1 (ENSG00000144355), score: 0.68 DLX2distal-less homeobox 2 (ENSG00000115844), score: 0.64 DNM1Ldynamin 1-like (ENSG00000087470), score: 0.61 DNM2dynamin 2 (ENSG00000079805), score: -0.66 DOCK4dedicator of cytokinesis 4 (ENSG00000128512), score: 0.61 DOK6docking protein 6 (ENSG00000206052), score: 0.66 DPP10dipeptidyl-peptidase 10 (non-functional) (ENSG00000175497), score: 0.72 DRD1dopamine receptor D1 (ENSG00000184845), score: 0.74 DRP2dystrophin related protein 2 (ENSG00000102385), score: 0.66 DSCAMDown syndrome cell adhesion molecule (ENSG00000171587), score: 0.66 DSG3desmoglein 3 (ENSG00000134757), score: 0.83 ECHDC2enoyl CoA hydratase domain containing 2 (ENSG00000121310), score: -0.61 EFR3AEFR3 homolog A (S. cerevisiae) (ENSG00000132294), score: 0.6 EGR3early growth response 3 (ENSG00000179388), score: 0.62 EIF3Geukaryotic translation initiation factor 3, subunit G (ENSG00000130811), score: -0.61 ELAVL2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) (ENSG00000107105), score: 0.62 ELAVL4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) (ENSG00000162374), score: 0.63 ELFN2extracellular leucine-rich repeat and fibronectin type III domain containing 2 (ENSG00000166897), score: 0.59 ENC1ectodermal-neural cortex 1 (with BTB-like domain) (ENSG00000171617), score: 0.67 ENDOUendonuclease, polyU-specific (ENSG00000111405), score: 0.64 EPHA4EPH receptor A4 (ENSG00000116106), score: 0.67 EPHA5EPH receptor A5 (ENSG00000145242), score: 0.75 EPHX4epoxide hydrolase 4 (ENSG00000172031), score: 0.65 ETV5ets variant 5 (ENSG00000244405), score: 0.7 FAM102Bfamily with sequence similarity 102, member B (ENSG00000162636), score: 0.64 FAM122Bfamily with sequence similarity 122B (ENSG00000156504), score: 0.6 FAM129Bfamily with sequence similarity 129, member B (ENSG00000136830), score: -0.63 FAM171Bfamily with sequence similarity 171, member B (ENSG00000144369), score: 0.59 FAM19A1family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 (ENSG00000183662), score: 0.75 FAM19A2family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 (ENSG00000198673), score: 0.79 FAM49Afamily with sequence similarity 49, member A (ENSG00000197872), score: 0.71 FAM49Bfamily with sequence similarity 49, member B (ENSG00000153310), score: 0.67 FAM5Bfamily with sequence similarity 5, member B (ENSG00000198797), score: 0.62 FAM5Cfamily with sequence similarity 5, member C (ENSG00000162670), score: 0.66 FAM73Afamily with sequence similarity 73, member A (ENSG00000180488), score: 0.71 FAM92Bfamily with sequence similarity 92, member B (ENSG00000153789), score: 0.92 FAR2fatty acyl CoA reductase 2 (ENSG00000064763), score: 0.73 FAT3FAT tumor suppressor homolog 3 (Drosophila) (ENSG00000165323), score: 0.69 FBLfibrillarin (ENSG00000105202), score: -0.68 FBXL17F-box and leucine-rich repeat protein 17 (ENSG00000145743), score: 0.65 FGF10fibroblast growth factor 10 (ENSG00000070193), score: 0.78 FLRT2fibronectin leucine rich transmembrane protein 2 (ENSG00000185070), score: 0.72 FOXP2forkhead box P2 (ENSG00000128573), score: 0.71 FREM3FRAS1 related extracellular matrix 3 (ENSG00000183090), score: 0.92 FRMPD4FERM and PDZ domain containing 4 (ENSG00000169933), score: 0.7 FZD3frizzled homolog 3 (Drosophila) (ENSG00000104290), score: 0.62 GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 2 (ENSG00000151834), score: 0.67 GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 4 (ENSG00000109158), score: 0.92 GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 3 (ENSG00000166206), score: 0.6 GABRG1gamma-aminobutyric acid (GABA) A receptor, gamma 1 (ENSG00000163285), score: 0.62 GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (ENSG00000136750), score: 0.67 GALNTL6UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6 (ENSG00000174473), score: 0.72 GJD2gap junction protein, delta 2, 36kDa (ENSG00000159248), score: 0.67 GLIPR1GLI pathogenesis-related 1 (ENSG00000139278), score: 0.6 GLMNglomulin, FKBP associated protein (ENSG00000174842), score: 0.68 GLRA3glycine receptor, alpha 3 (ENSG00000145451), score: 1 GPR149G protein-coupled receptor 149 (ENSG00000174948), score: 0.72 GPR26G protein-coupled receptor 26 (ENSG00000154478), score: 0.68 GPR63G protein-coupled receptor 63 (ENSG00000112218), score: 0.63 GPR83G protein-coupled receptor 83 (ENSG00000123901), score: 0.64 GPR98G protein-coupled receptor 98 (ENSG00000164199), score: 0.63 GRIA3glutamate receptor, ionotrophic, AMPA 3 (ENSG00000125675), score: 0.65 GRIK1glutamate receptor, ionotropic, kainate 1 (ENSG00000171189), score: 0.61 GRIK3glutamate receptor, ionotropic, kainate 3 (ENSG00000163873), score: 0.59 GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A (ENSG00000183454), score: 0.66 GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B (ENSG00000150086), score: 0.76 GRIN3Aglutamate receptor, ionotropic, N-methyl-D-aspartate 3A (ENSG00000198785), score: 0.63 GSX1GS homeobox 1 (ENSG00000169840), score: 0.65 GTDC1glycosyltransferase-like domain containing 1 (ENSG00000121964), score: 0.64 HAPLN1hyaluronan and proteoglycan link protein 1 (ENSG00000145681), score: 0.69 HCN1hyperpolarization activated cyclic nucleotide-gated potassium channel 1 (ENSG00000164588), score: 0.59 HCRTR1hypocretin (orexin) receptor 1 (ENSG00000121764), score: 0.59 HEATR5BHEAT repeat containing 5B (ENSG00000008869), score: 0.6 HECTD2HECT domain containing 2 (ENSG00000165338), score: 0.71 HIVEP2human immunodeficiency virus type I enhancer binding protein 2 (ENSG00000010818), score: 0.6 HN1Lhematological and neurological expressed 1-like (ENSG00000206053), score: -0.62 HNRNPFheterogeneous nuclear ribonucleoprotein F (ENSG00000169813), score: -0.62 HNRNPMheterogeneous nuclear ribonucleoprotein M (ENSG00000099783), score: -0.68 HOMER1homer homolog 1 (Drosophila) (ENSG00000152413), score: 0.63 HOPXHOP homeobox (ENSG00000171476), score: 0.61 HRH1histamine receptor H1 (ENSG00000196639), score: 0.74 HS2ST1heparan sulfate 2-O-sulfotransferase 1 (ENSG00000153936), score: 0.7 HS3ST4heparan sulfate (glucosamine) 3-O-sulfotransferase 4 (ENSG00000182601), score: 0.59 HSPA13heat shock protein 70kDa family, member 13 (ENSG00000155304), score: 0.64 HTR1A5-hydroxytryptamine (serotonin) receptor 1A (ENSG00000178394), score: 0.66 HTR1B5-hydroxytryptamine (serotonin) receptor 1B (ENSG00000135312), score: 0.81 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (ENSG00000102468), score: 0.79 HTR2C5-hydroxytryptamine (serotonin) receptor 2C (ENSG00000147246), score: 0.82 HTR3A5-hydroxytryptamine (serotonin) receptor 3A (ENSG00000166736), score: 0.78 HTR45-hydroxytryptamine (serotonin) receptor 4 (ENSG00000164270), score: 0.68 HTR65-hydroxytryptamine (serotonin) receptor 6 (ENSG00000158748), score: 0.7 IL1RAPL1interleukin 1 receptor accessory protein-like 1 (ENSG00000169306), score: 0.68 IL1RAPL2interleukin 1 receptor accessory protein-like 2 (ENSG00000189108), score: 0.84 IL9interleukin 9 (ENSG00000145839), score: 0.9 ILDR2immunoglobulin-like domain containing receptor 2 (ENSG00000143195), score: 0.65 IPCEF1interaction protein for cytohesin exchange factors 1 (ENSG00000074706), score: 0.65 ITFG1integrin alpha FG-GAP repeat containing 1 (ENSG00000129636), score: 0.73 JUPjunction plakoglobin (ENSG00000173801), score: -0.6 KAL1Kallmann syndrome 1 sequence (ENSG00000011201), score: 0.76 KCNA3potassium voltage-gated channel, shaker-related subfamily, member 3 (ENSG00000177272), score: 0.68 KCNA4potassium voltage-gated channel, shaker-related subfamily, member 4 (ENSG00000182255), score: 0.75 KCNA6potassium voltage-gated channel, shaker-related subfamily, member 6 (ENSG00000151079), score: 0.69 KCNAB1potassium voltage-gated channel, shaker-related subfamily, beta member 1 (ENSG00000169282), score: 0.6 KCNB1potassium voltage-gated channel, Shab-related subfamily, member 1 (ENSG00000158445), score: 0.64 KCNB2potassium voltage-gated channel, Shab-related subfamily, member 2 (ENSG00000182674), score: 0.8 KCNC2potassium voltage-gated channel, Shaw-related subfamily, member 2 (ENSG00000166006), score: 0.7 KCNH4potassium voltage-gated channel, subfamily H (eag-related), member 4 (ENSG00000089558), score: 0.76 KCNH7potassium voltage-gated channel, subfamily H (eag-related), member 7 (ENSG00000184611), score: 0.92 KCNJ6potassium inwardly-rectifying channel, subfamily J, member 6 (ENSG00000157542), score: 0.69 KCNK2potassium channel, subfamily K, member 2 (ENSG00000082482), score: 0.62 KCNMB2potassium large conductance calcium-activated channel, subfamily M, beta member 2 (ENSG00000197584), score: 0.77 KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 3 (ENSG00000184156), score: 0.69 KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5 (ENSG00000185760), score: 0.75 KCNS1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 (ENSG00000124134), score: 0.73 KCNS2potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 (ENSG00000156486), score: 0.77 KCNV1potassium channel, subfamily V, member 1 (ENSG00000164794), score: 0.77 KCTD16potassium channel tetramerisation domain containing 16 (ENSG00000183775), score: 0.8 KCTD4potassium channel tetramerisation domain containing 4 (ENSG00000180332), score: 0.64 KIAA0430KIAA0430 (ENSG00000166783), score: 0.61 KIAA0748KIAA0748 (ENSG00000135426), score: 0.68 KIAA1549KIAA1549 (ENSG00000122778), score: 0.61 KIAA2022KIAA2022 (ENSG00000050030), score: 0.84 KLHDC5kelch domain containing 5 (ENSG00000087448), score: 0.66 KLHL2kelch-like 2, Mayven (Drosophila) (ENSG00000109466), score: 0.62 LANCL3LanC lantibiotic synthetase component C-like 3 (bacterial) (ENSG00000147036), score: 0.6 LHFPL3lipoma HMGIC fusion partner-like 3 (ENSG00000187416), score: 0.61 LINGO2leucine rich repeat and Ig domain containing 2 (ENSG00000174482), score: 0.62 LMBRD2LMBR1 domain containing 2 (ENSG00000164187), score: 0.71 LMNAlamin A/C (ENSG00000160789), score: -0.68 LMO4LIM domain only 4 (ENSG00000143013), score: 0.64 LMTK2lemur tyrosine kinase 2 (ENSG00000164715), score: 0.63 LNX1ligand of numb-protein X 1 (ENSG00000072201), score: 0.61 LOC100293130similar to kruppel-related zinc finger protein hcKrox (ENSG00000160685), score: -0.67 LOC100293817similar to hCG1811893 (ENSG00000144460), score: 0.63 LOC100293905similar to gastrin-releasing peptide receptor (ENSG00000126010), score: 0.99 LOC644070germ cell-specific gene 1-like protein 2-like (ENSG00000214978), score: 0.73 LOC652725similar to neuron navigator 3 (ENSG00000067798), score: 0.62 LPPR4lipid phosphate phosphatase-related protein type 4 (ENSG00000117600), score: 0.69 LPPR5lipid phosphate phosphatase-related protein type 5 (ENSG00000117598), score: 0.72 LRFN2leucine rich repeat and fibronectin type III domain containing 2 (ENSG00000156564), score: 0.62 LRFN5leucine rich repeat and fibronectin type III domain containing 5 (ENSG00000165379), score: 0.69 LRP11low density lipoprotein receptor-related protein 11 (ENSG00000120256), score: 0.6 LRRC4Cleucine rich repeat containing 4C (ENSG00000148948), score: 0.64 LRRC55leucine rich repeat containing 55 (ENSG00000183908), score: 0.79 LRRC7leucine rich repeat containing 7 (ENSG00000033122), score: 0.7 LRRC8Bleucine rich repeat containing 8 family, member B (ENSG00000197147), score: 0.73 LRRTM2leucine rich repeat transmembrane neuronal 2 (ENSG00000146006), score: 0.64 LRRTM3leucine rich repeat transmembrane neuronal 3 (ENSG00000198739), score: 0.62 LRTM2leucine-rich repeats and transmembrane domains 2 (ENSG00000166159), score: 0.64 MANSC1MANSC domain containing 1 (ENSG00000111261), score: 0.62 MAP2K4mitogen-activated protein kinase kinase 4 (ENSG00000065559), score: 0.73 MAPK1mitogen-activated protein kinase 1 (ENSG00000100030), score: 0.68 MAPK8mitogen-activated protein kinase 8 (ENSG00000107643), score: 0.71 MARCH1membrane-associated ring finger (C3HC4) 1 (ENSG00000145416), score: 0.63 MAS1MAS1 oncogene (ENSG00000130368), score: 0.92 MCHR2melanin-concentrating hormone receptor 2 (ENSG00000152034), score: 0.61 MCM5minichromosome maintenance complex component 5 (ENSG00000100297), score: -0.62 MCM7minichromosome maintenance complex component 7 (ENSG00000166508), score: -0.62 MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 (ENSG00000139915), score: 0.85 MEF2Cmyocyte enhancer factor 2C (ENSG00000081189), score: 0.68 MEPEmatrix extracellular phosphoglycoprotein (ENSG00000152595), score: 0.85 MKL2MKL/myocardin-like 2 (ENSG00000186260), score: 0.75 MKNK2MAP kinase interacting serine/threonine kinase 2 (ENSG00000099875), score: -0.6 MMDmonocyte to macrophage differentiation-associated (ENSG00000108960), score: 0.72 MMP16matrix metallopeptidase 16 (membrane-inserted) (ENSG00000156103), score: 0.78 MTMR7myotubularin related protein 7 (ENSG00000003987), score: 0.61 MTMR9myotubularin related protein 9 (ENSG00000104643), score: 0.6 MTPNmyotrophin (ENSG00000105887), score: 0.68 MYBPC1myosin binding protein C, slow type (ENSG00000196091), score: 0.71 MYO5Amyosin VA (heavy chain 12, myoxin) (ENSG00000197535), score: 0.61 NAPGN-ethylmaleimide-sensitive factor attachment protein, gamma (ENSG00000134265), score: 0.68 NCALDneurocalcin delta (ENSG00000104490), score: 0.7 NCAM2neural cell adhesion molecule 2 (ENSG00000154654), score: 0.64 NCANneurocan (ENSG00000130287), score: 0.62 NCKAP1NCK-associated protein 1 (ENSG00000061676), score: 0.61 NDFIP1Nedd4 family interacting protein 1 (ENSG00000131507), score: 0.64 NECAB1N-terminal EF-hand calcium binding protein 1 (ENSG00000123119), score: 0.76 NETO1neuropilin (NRP) and tolloid (TLL)-like 1 (ENSG00000166342), score: 0.72 NEUROD6neurogenic differentiation 6 (ENSG00000164600), score: 0.68 NGBneuroglobin (ENSG00000165553), score: 0.64 NLGN4Xneuroligin 4, X-linked (ENSG00000146938), score: 0.59 NLKnemo-like kinase (ENSG00000087095), score: 0.72 NPBWR2neuropeptides B/W receptor 2 (ENSG00000125522), score: 0.61 NPEPL1aminopeptidase-like 1 (ENSG00000215440), score: -0.69 NPTNneuroplastin (ENSG00000156642), score: 0.6 NPY2Rneuropeptide Y receptor Y2 (ENSG00000185149), score: 0.81 NR3C2nuclear receptor subfamily 3, group C, member 2 (ENSG00000151623), score: 0.61 NRCAMneuronal cell adhesion molecule (ENSG00000091129), score: 0.61 NRG3neuregulin 3 (ENSG00000185737), score: 0.74 NRSN1neurensin 1 (ENSG00000152954), score: 0.64 NSFN-ethylmaleimide-sensitive factor (ENSG00000073969), score: 0.64 NT5DC35'-nucleotidase domain containing 3 (ENSG00000111696), score: 0.6 OPRD1opioid receptor, delta 1 (ENSG00000116329), score: 0.7 OSBPL1Aoxysterol binding protein-like 1A (ENSG00000141447), score: 0.64 OSBPL6oxysterol binding protein-like 6 (ENSG00000079156), score: 0.63 OSTNosteocrin (ENSG00000188729), score: 0.83 OTOSotospiralin (ENSG00000178602), score: 0.63 OTX1orthodenticle homeobox 1 (ENSG00000115507), score: 0.62 P2RY12purinergic receptor P2Y, G-protein coupled, 12 (ENSG00000169313), score: 0.76 PACSIN2protein kinase C and casein kinase substrate in neurons 2 (ENSG00000100266), score: -0.64 PANX1pannexin 1 (ENSG00000110218), score: 0.62 PCDH19protocadherin 19 (ENSG00000165194), score: 0.78 PCDH20protocadherin 20 (ENSG00000197991), score: 0.78 PCDH8protocadherin 8 (ENSG00000136099), score: 0.61 PCDH9protocadherin 9 (ENSG00000184226), score: 0.61 PCSK1proprotein convertase subtilisin/kexin type 1 (ENSG00000175426), score: 0.79 PDE7Bphosphodiesterase 7B (ENSG00000171408), score: 0.7 PDE8Bphosphodiesterase 8B (ENSG00000113231), score: 0.66 PDP1pyruvate dehyrogenase phosphatase catalytic subunit 1 (ENSG00000164951), score: 0.63 PDS5BPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) (ENSG00000083642), score: 0.69 PDYNprodynorphin (ENSG00000101327), score: 0.79 PDZRN4PDZ domain containing ring finger 4 (ENSG00000165966), score: 0.72 PEX5Lperoxisomal biogenesis factor 5-like (ENSG00000114757), score: 0.7 PGM2L1phosphoglucomutase 2-like 1 (ENSG00000165434), score: 0.71 PLCB1phospholipase C, beta 1 (phosphoinositide-specific) (ENSG00000182621), score: 0.76 PLCB3phospholipase C, beta 3 (phosphatidylinositol-specific) (ENSG00000149782), score: -0.61 PLEKHM3pleckstrin homology domain containing, family M, member 3 (ENSG00000178385), score: 0.64 PLP2proteolipid protein 2 (colonic epithelium-enriched) (ENSG00000102007), score: -0.59 PLXNA4plexin A4 (ENSG00000221866), score: 0.61 PNKPpolynucleotide kinase 3'-phosphatase (ENSG00000039650), score: -0.64 PNOCprepronociceptin (ENSG00000168081), score: 0.68 POFUT2protein O-fucosyltransferase 2 (ENSG00000186866), score: -0.6 PPFIA2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (ENSG00000139220), score: 0.59 PPP3CBprotein phosphatase 3, catalytic subunit, beta isozyme (ENSG00000107758), score: 0.6 PRICKLE2prickle homolog 2 (Drosophila) (ENSG00000163637), score: 0.72 PRKACBprotein kinase, cAMP-dependent, catalytic, beta (ENSG00000142875), score: 0.61 PRKCAprotein kinase C, alpha (ENSG00000154229), score: 0.64 PRKCSHprotein kinase C substrate 80K-H (ENSG00000130175), score: -0.6 PRKG2protein kinase, cGMP-dependent, type II (ENSG00000138669), score: 0.78 PRRG3proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) (ENSG00000130032), score: 0.61 PTBP1polypyrimidine tract binding protein 1 (ENSG00000011304), score: -0.63 PUM2pumilio homolog 2 (Drosophila) (ENSG00000055917), score: 0.6 PXNpaxillin (ENSG00000089159), score: -0.64 RAB11FIP2RAB11 family interacting protein 2 (class I) (ENSG00000107560), score: 0.7 RAB27BRAB27B, member RAS oncogene family (ENSG00000041353), score: 0.61 RAB39BRAB39B, member RAS oncogene family (ENSG00000155961), score: 0.61 RAB3BRAB3B, member RAS oncogene family (ENSG00000169213), score: 0.65 RAB3GAP2RAB3 GTPase activating protein subunit 2 (non-catalytic) (ENSG00000118873), score: 0.63 RANBP3LRAN binding protein 3-like (ENSG00000164188), score: 0.63 RAPGEF5Rap guanine nucleotide exchange factor (GEF) 5 (ENSG00000136237), score: 0.64 RBM42RNA binding motif protein 42 (ENSG00000126254), score: -0.67 RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian) (ENSG00000173039), score: -0.67 RGS4regulator of G-protein signaling 4 (ENSG00000117152), score: 0.73 RIMBP2RIMS binding protein 2 (ENSG00000060709), score: 0.61 RLBP1retinaldehyde binding protein 1 (ENSG00000140522), score: 0.66 RLIMring finger protein, LIM domain interacting (ENSG00000131263), score: 0.62 RNF11ring finger protein 11 (ENSG00000123091), score: 0.7 RNF24ring finger protein 24 (ENSG00000101236), score: 0.61 ROBO2roundabout, axon guidance receptor, homolog 2 (Drosophila) (ENSG00000185008), score: 0.64 ROCK2Rho-associated, coiled-coil containing protein kinase 2 (ENSG00000134318), score: 0.6 RORBRAR-related orphan receptor B (ENSG00000198963), score: 0.81 RPIAribose 5-phosphate isomerase A (ENSG00000153574), score: -0.59 RPS6KC1ribosomal protein S6 kinase, 52kDa, polypeptide 1 (ENSG00000136643), score: 0.6 RSPO2R-spondin 2 homolog (Xenopus laevis) (ENSG00000147655), score: 0.67 RXFP1relaxin/insulin-like family peptide receptor 1 (ENSG00000171509), score: 0.73 RXFP3relaxin/insulin-like family peptide receptor 3 (ENSG00000182631), score: 0.91 SACSspastic ataxia of Charlevoix-Saguenay (sacsin) (ENSG00000151835), score: 0.65 SAMD12sterile alpha motif domain containing 12 (ENSG00000177570), score: 0.68 SATB1SATB homeobox 1 (ENSG00000182568), score: 0.62 SATB2SATB homeobox 2 (ENSG00000119042), score: 0.66 SBNO2strawberry notch homolog 2 (Drosophila) (ENSG00000064932), score: -0.69 SCAMP1secretory carrier membrane protein 1 (ENSG00000085365), score: 0.6 SCG2secretogranin II (ENSG00000171951), score: 0.63 SCN1Asodium channel, voltage-gated, type I, alpha subunit (ENSG00000144285), score: 0.65 SCN3Asodium channel, voltage-gated, type III, alpha subunit (ENSG00000153253), score: 0.67 SCN3Bsodium channel, voltage-gated, type III, beta (ENSG00000166257), score: 0.64 SCN8Asodium channel, voltage gated, type VIII, alpha subunit (ENSG00000196876), score: 0.61 SEMA3Asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A (ENSG00000075213), score: 0.82 SEMA3Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E (ENSG00000170381), score: 0.62 SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D (ENSG00000137872), score: 0.61 SERPINB13serpin peptidase inhibitor, clade B (ovalbumin), member 13 (ENSG00000197641), score: 0.89 SERPINB6serpin peptidase inhibitor, clade B (ovalbumin), member 6 (ENSG00000124570), score: -0.6 SERPINI1serpin peptidase inhibitor, clade I (neuroserpin), member 1 (ENSG00000163536), score: 0.65 SERPINI2serpin peptidase inhibitor, clade I (pancpin), member 2 (ENSG00000114204), score: 0.63 SFRS16splicing factor, arginine/serine-rich 16 (ENSG00000104859), score: -0.59 SGIP1SH3-domain GRB2-like (endophilin) interacting protein 1 (ENSG00000118473), score: 0.61 SGTBsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, beta (ENSG00000197860), score: 0.7 SH2D4BSH2 domain containing 4B (ENSG00000178217), score: 0.93 SH2D5SH2 domain containing 5 (ENSG00000189410), score: 0.64 SHC3SHC (Src homology 2 domain containing) transforming protein 3 (ENSG00000148082), score: 0.7 SHOC2soc-2 suppressor of clear homolog (C. elegans) (ENSG00000108061), score: 0.64 SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2 (ENSG00000110436), score: 0.61 SLC24A2solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 (ENSG00000155886), score: 0.63 SLC24A4solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (ENSG00000140090), score: 0.67 SLC35F1solute carrier family 35, member F1 (ENSG00000196376), score: 0.64 SLC39A10solute carrier family 39 (zinc transporter), member 10 (ENSG00000196950), score: 0.75 SLC39A12solute carrier family 39 (zinc transporter), member 12 (ENSG00000148482), score: 0.76 SLC4A10solute carrier family 4, sodium bicarbonate transporter, member 10 (ENSG00000144290), score: 0.61 SLC7A3solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 (ENSG00000165349), score: 0.6 SLCO1C1solute carrier organic anion transporter family, member 1C1 (ENSG00000139155), score: 0.73 SLIT1slit homolog 1 (Drosophila) (ENSG00000187122), score: 0.59 SLITRK1SLIT and NTRK-like family, member 1 (ENSG00000178235), score: 0.68 SLITRK2SLIT and NTRK-like family, member 2 (ENSG00000185985), score: 0.66 SLITRK3SLIT and NTRK-like family, member 3 (ENSG00000121871), score: 0.59 SLITRK5SLIT and NTRK-like family, member 5 (ENSG00000165300), score: 0.63 SNTG1syntrophin, gamma 1 (ENSG00000147481), score: 0.72 SPATA20spermatogenesis associated 20 (ENSG00000006282), score: -0.61 SPIN1spindlin 1 (ENSG00000106723), score: 0.79 SPRED1sprouty-related, EVH1 domain containing 1 (ENSG00000166068), score: 0.66 SSNA1Sjogren syndrome nuclear autoantigen 1 (ENSG00000176101), score: -0.66 SSTsomatostatin (ENSG00000157005), score: 0.64 ST6GALNAC5ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ENSG00000117069), score: 0.66 STAU2staufen, RNA binding protein, homolog 2 (Drosophila) (ENSG00000040341), score: 0.68 STYK1serine/threonine/tyrosine kinase 1 (ENSG00000060140), score: 0.91 SYNJ1synaptojanin 1 (ENSG00000159082), score: 0.66 SYT16synaptotagmin XVI (ENSG00000139973), score: 0.65 SYT6synaptotagmin VI (ENSG00000134207), score: 0.65 TAC1tachykinin, precursor 1 (ENSG00000006128), score: 0.65 TAC3tachykinin 3 (ENSG00000166863), score: 0.69 TACR3tachykinin receptor 3 (ENSG00000169836), score: 0.6 TADA1transcriptional adaptor 1 (ENSG00000152382), score: 0.63 TBR1T-box, brain, 1 (ENSG00000136535), score: 0.66 THEMISthymocyte selection associated (ENSG00000172673), score: 0.6 THRBthyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) (ENSG00000151090), score: 0.63 TMEM132Dtransmembrane protein 132D (ENSG00000151952), score: 0.72 TMEM155transmembrane protein 155 (ENSG00000164112), score: 0.73 TMEM181transmembrane protein 181 (ENSG00000146433), score: 0.64 TMEM196transmembrane protein 196 (ENSG00000173452), score: 0.82 TMEM200Atransmembrane protein 200A (ENSG00000164484), score: 0.66 TMEM8Atransmembrane protein 8A (ENSG00000129925), score: -0.65 TRABDTraB domain containing (ENSG00000170638), score: -0.7 TRHRthyrotropin-releasing hormone receptor (ENSG00000174417), score: 0.98 TRIM23tripartite motif-containing 23 (ENSG00000113595), score: 0.59 TRPC5transient receptor potential cation channel, subfamily C, member 5 (ENSG00000072315), score: 0.9 TSHZ3teashirt zinc finger homeobox 3 (ENSG00000121297), score: 0.68 TTC24tetratricopeptide repeat domain 24 (ENSG00000187862), score: 0.61 UBE2Wubiquitin-conjugating enzyme E2W (putative) (ENSG00000104343), score: 0.6 UBLCP1ubiquitin-like domain containing CTD phosphatase 1 (ENSG00000164332), score: 0.6 UBQLN1ubiquilin 1 (ENSG00000135018), score: 0.71 UBXN1UBX domain protein 1 (ENSG00000162191), score: -0.66 UNC5Dunc-5 homolog D (C. elegans) (ENSG00000156687), score: 0.73 USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (ENSG00000101557), score: 0.62 VIPvasoactive intestinal peptide (ENSG00000146469), score: 0.78 VSTM2AV-set and transmembrane domain containing 2A (ENSG00000170419), score: 0.69 VTA1Vps20-associated 1 homolog (S. cerevisiae) (ENSG00000009844), score: 0.68 VWC2Lvon Willebrand factor C domain-containing protein 2-like (ENSG00000174453), score: 0.86 WDR47WD repeat domain 47 (ENSG00000085433), score: 0.6 WDR7WD repeat domain 7 (ENSG00000091157), score: 0.66 WDR92WD repeat domain 92 (ENSG00000221823), score: 0.63 WHSC1L1Wolf-Hirschhorn syndrome candidate 1-like 1 (ENSG00000147548), score: 0.6 WIPF2WAS/WASL interacting protein family, member 2 (ENSG00000171475), score: 0.61 WNT7Awingless-type MMTV integration site family, member 7A (ENSG00000154764), score: 0.6 WSB2WD repeat and SOCS box-containing 2 (ENSG00000176871), score: 0.62 XKR4XK, Kell blood group complex subunit-related family, member 4 (ENSG00000206579), score: 0.69 XYLT1xylosyltransferase I (ENSG00000103489), score: 0.62 YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide (ENSG00000166913), score: 0.6 ZC3H12Bzinc finger CCCH-type containing 12B (ENSG00000102053), score: 0.76 ZFP1zinc finger protein 1 homolog (mouse) (ENSG00000184517), score: 0.6 ZMAT3zinc finger, matrin type 3 (ENSG00000172667), score: 0.7 ZMAT4zinc finger, matrin type 4 (ENSG00000165061), score: 0.67 ZNF184zinc finger protein 184 (ENSG00000096654), score: 0.63 ZNF667zinc finger protein 667 (ENSG00000198046), score: 0.62 ZNF804Bzinc finger protein 804B (ENSG00000182348), score: 0.84 ZNF831zinc finger protein 831 (ENSG00000124203), score: 0.63 ZNF92zinc finger protein 92 (ENSG00000146757), score: 0.61 ZYG11Bzyg-11 homolog B (C. elegans) (ENSG00000162378), score: 0.66

Non-Entrez genes

ENSG00000196776Unknown, score: 0.74

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Id species tissue sex individual
hsa_br_m2_ca1 hsa br m 2
ptr_br_m4_ca1 ptr br m 4
ppa_br_m_ca1 ppa br m _
mml_br_f_ca1 mml br f _
mml_br_m2_ca1 mml br m 2
mml_br_m1_ca1 mml br m 1

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