Under-expression is coded with green,
over-expression with red color.
cell morphogenesis
The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form.
cell morphogenesis involved in differentiation
The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
metabolic process
The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.
cell growth
The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
startle response
An action or movement due to the application of a sudden unexpected stimulus.
generation of a signal involved in cell-cell signaling
The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
vesicle-mediated transport
The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane.
secretion
The controlled release of a substance by a cell, a group of cells, or a tissue.
cell adhesion
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
signal transduction
The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of nucleotide metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
purine nucleotide metabolic process
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
purine nucleotide biosynthetic process
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
cAMP biosynthetic process
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
nucleoside phosphate metabolic process
The chemical reactions and pathways involving any phosphorylated nucleoside.
nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium.
transport
The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.
ion transport
The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.
cation transport
The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.
potassium ion transport
The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.
calcium ion transport
The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore.
metal ion transport
The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.
neurotransmitter transport
The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
exocytosis
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells.
growth
The increase in size or mass of an entire organism, a part of an organism or a cell.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
homophilic cell adhesion
The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell.
cell surface receptor linked signaling pathway
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
G-protein coupled receptor protein signaling pathway
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
G-protein signaling, coupled to cyclic nucleotide second messenger
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
G-protein signaling, coupled to cAMP nucleotide second messenger
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
negative regulation of adenylate cyclase activity
Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity.
serotonin receptor signaling pathway
The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.
glutamate signaling pathway
The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
synaptic transmission
The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
nerve-nerve synaptic transmission
The process of communication from a neuron to another neuron across a synapse.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
nervous system development
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neurological system process
A organ system process carried out by any of the organs or tissues of neurological system.
axonogenesis
Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.
central nervous system development
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
brain development
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
sensory perception
The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.
behavior
The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
learning or memory
The acquisition and processing of information and/or the storage and retrieval of this information over time.
learning
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
memory
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
feeding behavior
Behavior associated with the intake of food.
visual behavior
The actions or reactions of an organism in response to a visual stimulus.
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
associative learning
Learning by associating a stimulus (the cause) with a particular outcome (the effect).
regulation of cell size
Any process that modulates the size of a cell.
cAMP metabolic process
The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
visual learning
Any process in an organism in which a change in behavior of an individual in response to repeated exposure to a visual cue.
biosynthetic process
The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
nucleotide metabolic process
The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).
nucleoside monophosphate metabolic process
The chemical reactions and pathways involving a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.
nucleoside monophosphate biosynthetic process
The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.
nucleotide biosynthetic process
The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
cyclic nucleotide metabolic process
The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
cyclic nucleotide biosynthetic process
The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
response to radiation
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.
response to light stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.
response to external stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
response to abiotic stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.
regulation of biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of cell communication
Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
positive regulation of cell communication
Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
negative regulation of cell communication
Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
negative regulation of cell development
Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
regulation of cell morphogenesis involved in differentiation
Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
regulation of neuron projection development
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
monovalent inorganic cation transport
The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.
di-, tri-valent inorganic cation transport
The directed movement of inorganic cations with a valency of two or three into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.
cellular component organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.
cell-cell adhesion
The attachment of one cell to another cell via adhesion molecules.
dendrite development
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell.
regulation of exocytosis
Any process that modulates the frequency, rate or extent of exocytosis.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
sensory perception of pain
The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.
second-messenger-mediated signaling
A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell.
cAMP-mediated signaling
A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.
cyclic-nucleotide-mediated signaling
A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response.
central nervous system neuron differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
neurogenesis
Generation of cells within the nervous system.
regulation of anatomical structure morphogenesis
Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.
regulation of cell morphogenesis
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process by which the shape of a cell is generated and organized.
biological adhesion
The attachment of a cell or organism to a substrate or other organism.
signaling pathway
The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.
intracellular signaling pathway
The series of molecular events whereby information is sent from one location to another within a cell.
signaling process
Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.
signaling
The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.
signal transmission
The process whereby a signal is released and/or conveyed from one location to another.
signal release
The process whereby a signal is secreted or discharged into the extracellular medium from a cellular source.
cell projection organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell differentiation
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
neuron differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a neuron.
regulation of cyclic nucleotide metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.
regulation of cyclic nucleotide biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.
regulation of nucleotide biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.
regulation of cAMP metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
regulation of cAMP biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
forebrain development
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
regulation of axon diameter
Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained.
neuron projection development
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
regulation of cyclase activity
Any process that modulates the frequency, rate or extent of cyclase activity.
negative regulation of cyclase activity
Any process that stops or reduces the activity of a cyclase.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
regulation of cell projection organization
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
regulation of neurological system process
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.
negative regulation of neurological system process
Any process that stops, prevents or reduces the frequency, rate or extent of a neurophysiological process.
positive regulation of neurological system process
Any process that activates or increases the frequency, rate or extent of a neurophysiological process.
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
regulation of cellular component size
A process that modulates the size of a cellular component.
regulation of cell projection size
A process that modulates the size of a cell projection.
regulation of localization
Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
secretion by cell
The controlled release of a substance by a cell.
cellular component morphogenesis
The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.
cell part morphogenesis
The process by which the anatomical structures of a cell part are generated and organized. Morphogenesis pertains to the creation of form.
nucleobase, nucleoside and nucleotide biosynthetic process
The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
intracellular signal transduction
The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
extracellular structure organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
negative regulation of catalytic activity
Any process that stops or reduces the activity of an enzyme.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
negative regulation of molecular function
Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
primary metabolic process
The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular nitrogen compound biosynthetic process
The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
small molecule metabolic process
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
regulation of cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
negative regulation of cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation.
regulation of neuron differentiation
Any process that modulates the frequency, rate or extent of neuron differentiation.
regulation of adenylate cyclase activity
Any process that modulates the frequency, rate or extent of adenylate cyclase activity.
heterocycle metabolic process
The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).
regulation of synaptic plasticity
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
regulation of neuronal synaptic plasticity
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
regulation of long-term neuronal synaptic plasticity
A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of biological process
Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of cellular process
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
developmental cell growth
The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
developmental growth
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
neuron development
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
cell morphogenesis involved in neuron differentiation
The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
axon extension
Long distance growth of a single process.
generation of neurons
The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
neuron projection morphogenesis
The process by which the anatomical structures of a neuron projection are generated and organized. Morphogenesis pertains to the creation of form. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
dendrite morphogenesis
The process by which the anatomical structures of a dendrite are generated and organized. Morphogenesis pertains to the creation of form. A dendrite is a freely branching protoplasmic process of a nerve cell.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cell projection morphogenesis
The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
regulation of neurogenesis
Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons.
negative regulation of neurogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons.
regulation of axonogenesis
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of catalytic activity
Any process that modulates the activity of an enzyme.
regulation of developmental process
Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of synapse structure and activity
Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
regulation of synaptic transmission
Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
negative regulation of synaptic transmission
Any process that stops, prevents or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
positive regulation of synaptic transmission
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
regulation of synapse organization
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
synapse organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
cognition
The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
neuromuscular process
Any process pertaining to the functions of the nervous and muscular systems of an organism.
regulation of secretion
Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.
regulation of transport
Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.
negative regulation of developmental process
Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of cellular component organization
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
regulation of nitrogen compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
localization
Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
positive regulation of multicellular organismal process
Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
negative regulation of multicellular organismal process
Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of lyase activity
Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
negative regulation of lyase activity
Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
regulation of nervous system development
Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.
regulation of transmission of nerve impulse
Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
negative regulation of transmission of nerve impulse
Any process that stops, prevents or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
positive regulation of transmission of nerve impulse
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
nucleobase, nucleoside and nucleotide metabolic process
The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.
regulation of cell development
Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
regulation of cellular localization
Any process that modulates the frequency, rate or extent of a process by which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
regulation of vesicle-mediated transport
Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
regulation of molecular function
Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
divalent metal ion transport
The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
regulation of anatomical structure size
Any process that modulates the size of an anatomical structure.
regulation of multicellular organismal development
Any process that modulates the frequency, rate or extent of multicellular organismal development.
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cell growth
The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
cellular metabolic process
The chemical reactions and pathways by which individual cells transform chemical substances.
cell projection organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
extracellular structure organization
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.
cell adhesion
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
generation of a signal involved in cell-cell signaling
The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.
signaling process
Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
developmental growth
The increase in size or mass of an entire organism, a part of an organism or a cell, where the increase in size or mass has the specific outcome of the progression of the organism over time from one condition to another.
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
positive regulation of multicellular organismal process
Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
negative regulation of cellular process
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of developmental process
Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
negative regulation of multicellular organismal process
Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
positive regulation of biological process
Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
negative regulation of biological process
Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of developmental process
Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of cellular process
Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of cellular component organization
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
regulation of multicellular organismal process
Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of localization
Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.
establishment of localization
The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.
cellular localization
Any process by which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within or in the membrane of a cell.
regulation of biological process
Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
regulation of biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances.
regulation of nitrogen compound metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
cellular nitrogen compound metabolic process
The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
cellular biosynthetic process
The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
regulation of primary metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
small molecule biosynthetic process
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
developmental cell growth
The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
signal release
The process whereby a signal is secreted or discharged into the extracellular medium from a cellular source.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
exocytosis
A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells.
positive regulation of cell communication
Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
negative regulation of cell communication
Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cellular component morphogenesis
The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.
regulation of cell communication
Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
regulation of cellular metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.
regulation of cell projection organization
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
positive regulation of cellular process
Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
negative regulation of cellular process
Any process that stops, prevents or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
regulation of vesicle-mediated transport
Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
establishment of localization in cell
The directed movement of a substance or cellular entity, such as a protein complex or organelle, to a specific location within, or in the membrane of, a cell.
regulation of cellular localization
Any process that modulates the frequency, rate or extent of a process by which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
regulation of cell morphogenesis
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process by which the shape of a cell is generated and organized.
regulation of cell projection organization
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.
regulation of synapse organization
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
signal transduction
The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
signal release
The process whereby a signal is secreted or discharged into the extracellular medium from a cellular source.
generation of a signal involved in cell-cell signaling
The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.
regulation of system process
Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.
positive regulation of multicellular organismal process
Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
negative regulation of multicellular organismal process
Any process that stops, prevents or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
regulation of multicellular organismal development
Any process that modulates the frequency, rate or extent of multicellular organismal development.
cellular component morphogenesis
The process by which cellular structures, including whole cells or cell parts, are generated and organized. Morphogenesis pertains to the creation of form.
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
regulation of anatomical structure morphogenesis
Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.
regulation of cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
negative regulation of developmental process
Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
regulation of multicellular organismal development
Any process that modulates the frequency, rate or extent of multicellular organismal development.
negative regulation of cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation.
regulation of cellular localization
Any process that modulates the frequency, rate or extent of a process by which a cell, a substance, or a cellular entity is transported to, or maintained in a specific location within or in the membrane of a cell.
visual behavior
The actions or reactions of an organism in response to a visual stimulus.
vesicle-mediated transport
The directed movement of substances into, out of or within a cell by a cellular process that begins with the formation of membrane-bounded vesicles in which the transported substances are enclosed or located in the vesicle membrane. Vesicles are then targeted to, and fuse with, an acceptor membrane.
regulation of transport
Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells by means of some external agent such as a transporter or pore.
secretion by cell
The controlled release of a substance by a cell.
regulation of catalytic activity
Any process that modulates the activity of an enzyme.
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
cellular nitrogen compound biosynthetic process
The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of cellular biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.
nucleobase, nucleoside and nucleotide metabolic process
The cellular chemical reactions and pathways involving nucleobases, nucleosides and nucleotides.
nucleobase, nucleoside and nucleotide biosynthetic process
The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides.
regulation of exocytosis
Any process that modulates the frequency, rate or extent of exocytosis.
positive regulation of cell communication
Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
negative regulation of cell communication
Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
synaptic transmission
The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
regulation of transmission of nerve impulse
Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
negative regulation of transmission of nerve impulse
Any process that stops, prevents or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
positive regulation of transmission of nerve impulse
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
dendrite development
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell.
regulation of neuron projection development
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
neuron projection morphogenesis
The process by which the anatomical structures of a neuron projection are generated and organized. Morphogenesis pertains to the creation of form. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
regulation of synapse organization
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
regulation of cell differentiation
Any process that modulates the frequency, rate or extent of cell differentiation, the process whereby relatively unspecialized cells acquire specialized structural and functional features.
negative regulation of cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation.
cell development
The process whose specific outcome is the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
negative regulation of cell development
Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
developmental cell growth
The growth of a cell, where growth contributes to the progression of the cell over time from one condition to another.
negative regulation of cell differentiation
Any process that stops, prevents or reduces the frequency, rate or extent of cell differentiation.
regulation of cell development
Any process that modulates the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
regulation of exocytosis
Any process that modulates the frequency, rate or extent of exocytosis.
cell growth
The process by which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.
cell morphogenesis involved in differentiation
The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
regulation of cell morphogenesis
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process by which the shape of a cell is generated and organized.
cell projection morphogenesis
The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.
cell projection morphogenesis
The process by which the anatomical structures of a cell projection are generated and organized. Morphogenesis pertains to the creation of form.
regulation of synapse structure and activity
Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
intracellular signal transduction
The process whereby a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
negative regulation of neurological system process
Any process that stops, prevents or reduces the frequency, rate or extent of a neurophysiological process.
positive regulation of neurological system process
Any process that activates or increases the frequency, rate or extent of a neurophysiological process.
regulation of neurological system process
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
positive regulation of transmission of nerve impulse
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
negative regulation of transmission of nerve impulse
Any process that stops, prevents or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
regulation of cell morphogenesis
Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process by which the shape of a cell is generated and organized.
regulation of vesicle-mediated transport
Any process that modulates the rate, frequency, or extent of vesicle-mediated transport, the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell.
secretion by cell
The controlled release of a substance by a cell.
regulation of secretion
Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or group of cells.
regulation of synapse organization
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
regulation of cellular component size
A process that modulates the size of a cellular component.
negative regulation of catalytic activity
Any process that stops or reduces the activity of an enzyme.
nucleobase, nucleoside, nucleotide and nucleic acid biosynthetic process
The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids.
negative regulation of cyclase activity
Any process that stops or reduces the activity of a cyclase.
regulation of adenylate cyclase activity
Any process that modulates the frequency, rate or extent of adenylate cyclase activity.
negative regulation of lyase activity
Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
nucleobase, nucleoside and nucleotide biosynthetic process
The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides and nucleotides.
regulation of synaptic transmission
Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
negative regulation of transmission of nerve impulse
Any process that stops, prevents or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
positive regulation of transmission of nerve impulse
Any process that activates, maintains or increases the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
positive regulation of synaptic transmission
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
negative regulation of synaptic transmission
Any process that stops, prevents or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
dendrite morphogenesis
The process by which the anatomical structures of a dendrite are generated and organized. Morphogenesis pertains to the creation of form. A dendrite is a freely branching protoplasmic process of a nerve cell.
negative regulation of neurogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons.
neuron development
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
regulation of cell morphogenesis involved in differentiation
Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
neuron projection development
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
cell morphogenesis involved in neuron differentiation
The process by which the structures of a neuron are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a neuron.
negative regulation of cell development
Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
regulation of cell morphogenesis involved in differentiation
Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.
regulation of neurogenesis
Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons.
regulation of axonogenesis
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
regulation of synaptic plasticity
A process that modulates synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
negative regulation of synaptic transmission
Any process that stops, prevents or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
positive regulation of synaptic transmission
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
negative regulation of neurological system process
Any process that stops, prevents or reduces the frequency, rate or extent of a neurophysiological process.
positive regulation of neurological system process
Any process that activates or increases the frequency, rate or extent of a neurophysiological process.
regulation of transmission of nerve impulse
Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
learning or memory
The acquisition and processing of information and/or the storage and retrieval of this information over time.
startle response
An action or movement due to the application of a sudden unexpected stimulus.
central nervous system development
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
neurogenesis
Generation of cells within the nervous system.
regulation of nervous system development
Any process that modulates the frequency, rate or extent of nervous system development, the origin and formation of nervous tissue.
brain development
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
central nervous system neuron differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.
regulation of neurogenesis
Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons.
forebrain development
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).
regulation of exocytosis
Any process that modulates the frequency, rate or extent of exocytosis.
visual behavior
The actions or reactions of an organism in response to a visual stimulus.
regulation of nucleotide biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.
purine nucleotide biosynthetic process
The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
regulation of nucleotide biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.
negative regulation of adenylate cyclase activity
Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity.
negative regulation of adenylate cyclase activity
Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity.
cAMP biosynthetic process
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
regulation of nucleotide metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides.
purine nucleotide metabolic process
The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety.
nucleotide biosynthetic process
The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).
regulation of axon diameter
Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained.
axon extension
Long distance growth of a single process.
regulation of axonogenesis
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
neuron differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a neuron.
regulation of neurogenesis
Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons.
regulation of neuron differentiation
Any process that modulates the frequency, rate or extent of neuron differentiation.
negative regulation of neurogenesis
Any process that stops, prevents or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons.
regulation of neuron projection development
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
axonogenesis
Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.
dendrite morphogenesis
The process by which the anatomical structures of a dendrite are generated and organized. Morphogenesis pertains to the creation of form. A dendrite is a freely branching protoplasmic process of a nerve cell.
visual learning
Any process in an organism in which a change in behavior of an individual in response to repeated exposure to a visual cue.
potassium ion transport
The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore.
divalent metal ion transport
The directed movement of divalent metal cations, any metal ion with a +2 electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.
regulation of cyclic nucleotide biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.
regulation of cAMP metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
regulation of cAMP biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
regulation of cAMP biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
nucleoside monophosphate biosynthetic process
The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety.
G-protein signaling, coupled to cyclic nucleotide second messenger
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.
regulation of adenylate cyclase activity
Any process that modulates the frequency, rate or extent of adenylate cyclase activity.
cAMP biosynthetic process
The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
regulation of cyclic nucleotide biosynthetic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.
cAMP metabolic process
The chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate).
cyclic nucleotide biosynthetic process
The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
regulation of cyclic nucleotide metabolic process
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.
G-protein signaling, coupled to cAMP nucleotide second messenger
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
intracellular
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
cell fraction
A generic term for parts of cells prepared by disruptive biochemical techniques.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
integral to membrane
Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
membrane fraction
That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes.
insoluble fraction
That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water.
cytoplasm
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
calcium- and calmodulin-dependent protein kinase complex
An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.
synaptic vesicle
A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
voltage-gated potassium channel complex
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
ionotropic glutamate receptor complex
A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.
endomembrane system
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
vesicle membrane
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
postsynaptic density
The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
synaptosome
Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma.
cell junction
A plasma membrane part that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
coated vesicle
Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
clathrin-coated vesicle
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
outer membrane-bounded periplasmic space
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall.
external encapsulating structure
A structure that lies outside the plasma membrane and surrounds the entire cell.
cell envelope
An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
axon
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
dendrite
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
growth cone
The migrating motile tip of a growing nerve cell axon or dendrite.
site of polarized growth
Any part of a cell where non-isotropic growth takes place.
cytoplasmic vesicle membrane
The lipid bilayer surrounding a cytoplasmic vesicle.
coated vesicle membrane
The lipid bilayer surrounding a coated vesicle.
clathrin coated vesicle membrane
The lipid bilayer surrounding a clathrin-coated vesicle.
synaptic vesicle membrane
The lipid bilayer surrounding a synaptic vesicle.
organelle membrane
The lipid bilayer surrounding an organelle.
intrinsic to membrane
Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
envelope
A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.
vesicle
Any small, fluid-filled, spherical organelle enclosed by membrane or protein.
membrane-bounded vesicle
Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.
asymmetric synapse
A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
axon part
A part of an axon, a cell projection of a neuron.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
cation channel complex
An ion channel complex through which cations pass.
potassium channel complex
An ion channel complex through which potassium ions pass.
chloride channel complex
An ion channel complex through which chloride ions pass.
periplasmic space
The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi).
presynaptic membrane
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
cell projection
A prolongation or process extending from a cell, e.g. a flagellum or axon.
neuron projection
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
neuronal cell body
The portion of a neuron that includes the nucleus, but excludes all cell projections such as axons and dendrites.
dendritic spine
Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
dendritic shaft
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
perikaryon
The portion of the cell soma (cell body) that excludes the nucleus.
organelle
Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.
receptor complex
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
axon terminus
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
cell body
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
neuron projection terminus
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
neuron spine
A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
synapse part
Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
external encapsulating structure part
Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell.
cell projection part
Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
synapse
The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
postsynaptic membrane
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
excitatory synapse
A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
organelle part
Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.
synapse part
Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
organelle membrane
The lipid bilayer surrounding an organelle.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
intracellular membrane-bounded organelle
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
intracellular non-membrane-bounded organelle
Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
intracellular part
Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
organelle membrane
The lipid bilayer surrounding an organelle.
presynaptic membrane
A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
postsynaptic membrane
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.
vesicle membrane
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
external encapsulating structure part
Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell.
cell projection part
Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.
calcium- and calmodulin-dependent protein kinase complex
An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins.
intracellular organelle
Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
intracellular organelle part
A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
outer membrane-bounded periplasmic space
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall.
growth cone
The migrating motile tip of a growing nerve cell axon or dendrite.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
vesicle membrane
The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
cytoplasmic membrane-bounded vesicle
A membrane-bounded vesicle found in the cytoplasm of the cell.
postsynaptic density
The post synaptic density is a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. It forms a disc that consists of a range of proteins with different functions, some of which contact the cytoplasmic domains of ion channels in the postsynaptic membrane. The proteins making up the disc include receptors, and structural proteins linked to the actin cytoskeleton. They also include signalling machinery, such as protein kinases and phosphatases.
cytoplasmic vesicle membrane
The lipid bilayer surrounding a cytoplasmic vesicle.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
outer membrane-bounded periplasmic space
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall.
growth cone
The migrating motile tip of a growing nerve cell axon or dendrite.
neuron projection terminus
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
perikaryon
The portion of the cell soma (cell body) that excludes the nucleus.
cytoplasmic part
Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic vesicle
A vesicle formed of membrane or protein, found in the cytoplasm of a cell.
cytoplasmic vesicle part
Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.
ionotropic glutamate receptor complex
A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.
intrinsic to plasma membrane
Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.
axon terminus
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
cytoplasmic vesicle membrane
The lipid bilayer surrounding a cytoplasmic vesicle.
cytoskeletal part
Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.
axon part
A part of an axon, a cell projection of a neuron.
dendritic spine
Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
dendritic shaft
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
dendritic spine
Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
ion channel complex
A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
integral to plasma membrane
Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.
voltage-gated potassium channel complex
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
coated vesicle membrane
The lipid bilayer surrounding a coated vesicle.
voltage-gated potassium channel complex
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
ionotropic glutamate receptor complex
A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.
synaptic vesicle
A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
clathrin coated vesicle membrane
The lipid bilayer surrounding a clathrin-coated vesicle.
synaptic vesicle membrane
The lipid bilayer surrounding a synaptic vesicle.
protein binding
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
calcium ion binding
Interacting selectively and non-covalently with calcium ions (Ca2+).
adenylate cyclase inhibiting metabotropic glutamate receptor activity
A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
catalytic activity
Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
receptor binding
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
inositol or phosphatidylinositol phosphodiesterase activity
NA
phosphoinositide phospholipase C activity
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
phospholipase activity
Catalysis of the hydrolysis of a glycerophospholipid.
phospholipase C activity
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
protein kinase activity
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine/threonine kinase activity
Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate.
calmodulin-dependent protein kinase activity
Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium-bound calmodulin.
protein tyrosine kinase activity
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
transmembrane receptor protein tyrosine kinase activity
Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
G-protein coupled receptor activity
A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
ionotropic glutamate receptor activity
Combining with glutamate to initiate a change in cell activity through the regulation of ion channels.
serotonin receptor activity
Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity.
ephrin receptor activity
Combining with an ephrin to initiate a change in cell activity.
transmembrane-ephrin receptor activity
NA
hormone activity
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
neuropeptide hormone activity
The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones.
transporter activity
Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
ion channel activity
Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
extracellular ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts.
excitatory extracellular ligand-gated ion channel activity
NA
extracellular-glutamate-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts.
voltage-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.
voltage-gated potassium channel activity
Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.
cation channel activity
Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
potassium channel activity
Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
transmembrane transporter activity
Enables the transfer of a substance from one side of a membrane to the other.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
metal ion binding
Interacting selectively and non-covalently with any metal ion.
calmodulin binding
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
glutamate receptor activity
Combining with glutamate to initiate a change in cell activity.
phosphoric diester hydrolase activity
Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
drug binding
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
G-protein coupled amine receptor activity
A receptor that binds an extracellular amine and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
cation transmembrane transporter activity
Catalysis of the transfer of cation from one side of the membrane to the other.
benzodiazepine receptor activity
Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.
ion transmembrane transporter activity
Catalysis of the transfer of an ion from one side of a membrane to the other.
channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
lipase activity
Catalysis of the hydrolysis of a lipid or phospholipid.
kinase activity
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
transferase activity
Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
transferase activity, transferring phosphorus-containing groups
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
phosphotransferase activity, alcohol group as acceptor
Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).
hydrolase activity
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
hydrolase activity, acting on ester bonds
Catalysis of the hydrolysis of any ester bond.
GABA receptor activity
Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity.
transmembrane receptor protein kinase activity
NA
passive transmembrane transporter activity
Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.
voltage-gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
ligand-gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
gated channel activity
Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.
substrate-specific channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
voltage-gated cation channel activity
Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
substrate-specific transporter activity
Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.
neurotransmitter receptor activity
Combining with a neurotransmitter to initiate a change in cell activity.
neurotransmitter binding
Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.
phosphoric ester hydrolase activity
Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.
ion binding
Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.
cation binding
Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.
amine binding
Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.
serotonin binding
Interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
NA
substrate-specific transmembrane transporter activity
Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.
neurotransmitter receptor activity
Combining with a neurotransmitter to initiate a change in cell activity.
protein kinase activity
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
substrate-specific channel activity
Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.
ion channel activity
Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
transmembrane receptor protein kinase activity
NA
phospholipase C activity
Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
cation channel activity
Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.
adenylate cyclase inhibiting metabotropic glutamate receptor activity
A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity.
transmembrane receptor protein tyrosine kinase activity
Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity.
phosphoinositide phospholipase C activity
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
voltage-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons.
ligand-gated ion channel activity
Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.
voltage-gated cation channel activity
Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion.
voltage-gated potassium channel activity
Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel.
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 04080 | 4.257e-16 | 8.539 | 42 | 206 | Neuroactive ligand-receptor interaction |
| 04020 | 5.807e-11 | 6.01 | 29 | 145 | Calcium signaling pathway |
| 04720 | 1.620e-10 | 2.197 | 18 | 53 | Long-term potentiation |
| 04971 | 5.658e-06 | 2.487 | 14 | 60 | Gastric acid secretion |
| 04916 | 7.561e-06 | 3.357 | 16 | 81 | Melanogenesis |
| 04360 | 1.295e-05 | 4.394 | 18 | 106 | Axon guidance |
| 04540 | 2.933e-05 | 2.446 | 13 | 59 | Gap junction |
| 04970 | 3.555e-05 | 2.487 | 13 | 60 | Salivary secretion |
| 05214 | 8.185e-05 | 2.28 | 12 | 55 | Glioma |
| 04730 | 3.832e-04 | 2.238 | 11 | 54 | Long-term depression |
| 04912 | 7.098e-04 | 3.316 | 13 | 80 | GnRH signaling pathway |
| 05014 | 1.134e-03 | 1.699 | 9 | 41 | Amyotrophic lateral sclerosis (ALS) |
| 04114 | 2.145e-03 | 3.73 | 13 | 90 | Oocyte meiosis |
| 04070 | 2.393e-03 | 2.777 | 11 | 67 | Phosphatidylinositol signaling system |
| 04270 | 2.644e-03 | 3.813 | 13 | 92 | Vascular smooth muscle contraction |
| 04012 | 5.228e-03 | 3.067 | 11 | 74 | ErbB signaling pathway |
| 04310 | 7.109e-03 | 4.85 | 14 | 117 | Wnt signaling pathway |
| 04666 | 1.181e-02 | 2.901 | 10 | 70 | Fc gamma R-mediated phagocytosis |
| 04370 | 1.669e-02 | 2.528 | 9 | 61 | VEGF signaling pathway |
| 04722 | 1.862e-02 | 4.228 | 12 | 102 | Neurotrophin signaling pathway |
| 04650 | 4.463e-02 | 3.565 | 10 | 86 | Natural killer cell mediated cytotoxicity |
ABRactive BCR-related gene (ENSG00000159842), score: 0.76 ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif, 8 (ENSG00000134917), score: 0.88 ADCY2adenylate cyclase 2 (brain) (ENSG00000078295), score: 0.8 ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary) (ENSG00000141433), score: 0.83 ADRA1Dadrenergic, alpha-1D-, receptor (ENSG00000171873), score: 0.88 AK5adenylate kinase 5 (ENSG00000154027), score: 0.93 AMPHamphiphysin (ENSG00000078053), score: 0.76 ANO3anoctamin 3 (ENSG00000134343), score: 0.92 ANO4anoctamin 4 (ENSG00000151572), score: 0.78 APBA1amyloid beta (A4) precursor protein-binding, family A, member 1 (ENSG00000107282), score: 0.75 ARCactivity-regulated cytoskeleton-associated protein (ENSG00000198576), score: 0.9 ARHGAP32Rho GTPase activating protein 32 (ENSG00000134909), score: 0.79 ARHGEF9Cdc42 guanine nucleotide exchange factor (GEF) 9 (ENSG00000131089), score: 0.75 ARNT2aryl-hydrocarbon receptor nuclear translocator 2 (ENSG00000172379), score: 0.77 ATL1atlastin GTPase 1 (ENSG00000198513), score: 0.75 ATP2B1ATPase, Ca++ transporting, plasma membrane 1 (ENSG00000070961), score: 0.78 ATP6V1HATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H (ENSG00000047249), score: 0.76 ATRNL1attractin-like 1 (ENSG00000107518), score: 0.87 B3GALT1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 (ENSG00000172318), score: 0.76 B3GAT1beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) (ENSG00000109956), score: 0.77 B3GNT1UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (ENSG00000174684), score: 0.75 B4GALT1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (ENSG00000086062), score: -0.76 BAALCbrain and acute leukemia, cytoplasmic (ENSG00000164929), score: 0.75 BAI1brain-specific angiogenesis inhibitor 1 (ENSG00000181790), score: 0.85 BAI2brain-specific angiogenesis inhibitor 2 (ENSG00000121753), score: 0.8 BASP1brain abundant, membrane attached signal protein 1 (ENSG00000176788), score: 0.82 BCAT1branched chain amino-acid transaminase 1, cytosolic (ENSG00000060982), score: 0.77 BCL11AB-cell CLL/lymphoma 11A (zinc finger protein) (ENSG00000119866), score: 0.89 BCL11BB-cell CLL/lymphoma 11B (zinc finger protein) (ENSG00000127152), score: 0.94 BTBD9BTB (POZ) domain containing 9 (ENSG00000183826), score: 0.76 C11orf41chromosome 11 open reading frame 41 (ENSG00000110427), score: 0.81 C11orf87chromosome 11 open reading frame 87 (ENSG00000185742), score: 0.91 C12orf76chromosome 12 open reading frame 76 (ENSG00000174456), score: 0.8 C13orf36chromosome 13 open reading frame 36 (ENSG00000180440), score: 0.96 C19orf26chromosome 19 open reading frame 26 (ENSG00000099625), score: 0.74 C1orf216chromosome 1 open reading frame 216 (ENSG00000142686), score: 0.78 C1orf95chromosome 1 open reading frame 95 (ENSG00000203685), score: 0.86 C1QL2complement component 1, q subcomponent-like 2 (ENSG00000144119), score: 0.89 C1QTNF4C1q and tumor necrosis factor related protein 4 (ENSG00000172247), score: 0.75 C20orf103chromosome 20 open reading frame 103 (ENSG00000125869), score: 0.89 C2orf55chromosome 2 open reading frame 55 (ENSG00000196872), score: 0.83 C2orf80chromosome 2 open reading frame 80 (ENSG00000188674), score: 0.92 C5orf30chromosome 5 open reading frame 30 (ENSG00000181751), score: 0.77 C5orf40chromosome 5 open reading frame 40 (ENSG00000172568), score: 0.82 C6orf168chromosome 6 open reading frame 168 (ENSG00000146267), score: 0.75 C7orf52chromosome 7 open reading frame 52 (ENSG00000167011), score: 0.75 C8orf46chromosome 8 open reading frame 46 (ENSG00000169085), score: 0.86 C9orf91chromosome 9 open reading frame 91 (ENSG00000157693), score: 0.86 CA7carbonic anhydrase VII (ENSG00000168748), score: 0.79 CABP1calcium binding protein 1 (ENSG00000157782), score: 0.8 CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunit (ENSG00000198216), score: 0.78 CACNG3calcium channel, voltage-dependent, gamma subunit 3 (ENSG00000006116), score: 0.96 CALM1calmodulin 1 (phosphorylase kinase, delta) (ENSG00000160014), score: 0.8 CALYcalcyon neuron-specific vesicular protein (ENSG00000130643), score: 0.83 CAMK1Dcalcium/calmodulin-dependent protein kinase ID (ENSG00000183049), score: 0.75 CAMK1Gcalcium/calmodulin-dependent protein kinase IG (ENSG00000008118), score: 0.94 CAMK2Acalcium/calmodulin-dependent protein kinase II alpha (ENSG00000070808), score: 0.94 CAMK2Gcalcium/calmodulin-dependent protein kinase II gamma (ENSG00000148660), score: 0.8 CAMK2N1calcium/calmodulin-dependent protein kinase II inhibitor 1 (ENSG00000162545), score: 0.78 CAMKK1calcium/calmodulin-dependent protein kinase kinase 1, alpha (ENSG00000004660), score: 0.81 CBLN2cerebellin 2 precursor (ENSG00000141668), score: 0.97 CBLN4cerebellin 4 precursor (ENSG00000054803), score: 0.98 CCDC85Acoiled-coil domain containing 85A (ENSG00000055813), score: 0.79 CCKBRcholecystokinin B receptor (ENSG00000110148), score: 0.84 CDH10cadherin 10, type 2 (T2-cadherin) (ENSG00000040731), score: 0.8 CDH12cadherin 12, type 2 (N-cadherin 2) (ENSG00000154162), score: 0.91 CDH4cadherin 4, type 1, R-cadherin (retinal) (ENSG00000179242), score: 0.79 CDH8cadherin 8, type 2 (ENSG00000150394), score: 0.96 CDH9cadherin 9, type 2 (T1-cadherin) (ENSG00000113100), score: 0.93 CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39) (ENSG00000171450), score: 0.82 CDKN2Dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) (ENSG00000129355), score: 0.76 CELF5CUGBP, Elav-like family member 5 (ENSG00000161082), score: 0.77 CELSR2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) (ENSG00000143126), score: 0.75 CHGAchromogranin A (parathyroid secretory protein 1) (ENSG00000100604), score: 0.93 CHN1chimerin (chimaerin) 1 (ENSG00000128656), score: 0.81 CHRM1cholinergic receptor, muscarinic 1 (ENSG00000168539), score: 0.97 CHRM3cholinergic receptor, muscarinic 3 (ENSG00000133019), score: 0.96 CHRNB2cholinergic receptor, nicotinic, beta 2 (neuronal) (ENSG00000160716), score: 0.8 CHST1carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 (ENSG00000175264), score: 0.88 CHST8carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 (ENSG00000124302), score: 0.76 CHSY3chondroitin sulfate synthase 3 (ENSG00000198108), score: 0.81 CLSTN2calsyntenin 2 (ENSG00000158258), score: 0.77 CNIH2cornichon homolog 2 (Drosophila) (ENSG00000174871), score: 0.75 CNIH3cornichon homolog 3 (Drosophila) (ENSG00000143786), score: 0.79 CNTN3contactin 3 (plasmacytoma associated) (ENSG00000113805), score: 0.82 CNTN5contactin 5 (ENSG00000149972), score: 0.84 CNTNAP5contactin associated protein-like 5 (ENSG00000155052), score: 0.89 COL11A1collagen, type XI, alpha 1 (ENSG00000060718), score: 0.83 CPNE4copine IV (ENSG00000196353), score: 0.77 CPNE5copine V (ENSG00000124772), score: 0.79 CPNE6copine VI (neuronal) (ENSG00000100884), score: 0.83 CREG2cellular repressor of E1A-stimulated genes 2 (ENSG00000175874), score: 0.98 CRHcorticotropin releasing hormone (ENSG00000147571), score: 0.89 CSMD3CUB and Sushi multiple domains 3 (ENSG00000164796), score: 0.9 CSRNP3cysteine-serine-rich nuclear protein 3 (ENSG00000178662), score: 0.87 CTNNA2catenin (cadherin-associated protein), alpha 2 (ENSG00000066032), score: 0.78 CYP46A1cytochrome P450, family 46, subfamily A, polypeptide 1 (ENSG00000036530), score: 0.88 DACH2dachshund homolog 2 (Drosophila) (ENSG00000126733), score: 0.8 DAGLAdiacylglycerol lipase, alpha (ENSG00000134780), score: 0.81 DCLK1doublecortin-like kinase 1 (ENSG00000133083), score: 0.84 DCXdoublecortin (ENSG00000077279), score: 0.87 DDNdendrin (ENSG00000181418), score: 0.86 DGKBdiacylglycerol kinase, beta 90kDa (ENSG00000136267), score: 0.93 DGKZdiacylglycerol kinase, zeta 104kDa (ENSG00000149091), score: 0.8 DLX1distal-less homeobox 1 (ENSG00000144355), score: 0.98 DLX2distal-less homeobox 2 (ENSG00000115844), score: 0.89 DLX5distal-less homeobox 5 (ENSG00000105880), score: 0.83 DNM1dynamin 1 (ENSG00000106976), score: 0.75 DOCK4dedicator of cytokinesis 4 (ENSG00000128512), score: 0.77 DPP10dipeptidyl-peptidase 10 (non-functional) (ENSG00000175497), score: 0.92 DRD1dopamine receptor D1 (ENSG00000184845), score: 0.8 DRP2dystrophin related protein 2 (ENSG00000102385), score: 0.9 DSCAMDown syndrome cell adhesion molecule (ENSG00000171587), score: 0.89 EDIL3EGF-like repeats and discoidin I-like domains 3 (ENSG00000164176), score: 0.76 EDN3endothelin 3 (ENSG00000124205), score: 0.75 EFNA3ephrin-A3 (ENSG00000143590), score: 0.86 EFNB3ephrin-B3 (ENSG00000108947), score: 0.89 EGR3early growth response 3 (ENSG00000179388), score: 0.91 ELAVL4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) (ENSG00000162374), score: 0.75 ELFN2extracellular leucine-rich repeat and fibronectin type III domain containing 2 (ENSG00000166897), score: 0.9 ELMOD1ELMO/CED-12 domain containing 1 (ENSG00000110675), score: 0.76 ENC1ectodermal-neural cortex 1 (with BTB-like domain) (ENSG00000171617), score: 0.96 EPHA4EPH receptor A4 (ENSG00000116106), score: 0.85 EPHA5EPH receptor A5 (ENSG00000145242), score: 0.93 EPHB6EPH receptor B6 (ENSG00000106123), score: 0.84 EPHX4epoxide hydrolase 4 (ENSG00000172031), score: 0.95 ETV5ets variant 5 (ENSG00000244405), score: 0.74 EXTL1exostoses (multiple)-like 1 (ENSG00000158008), score: 0.8 FAM155Afamily with sequence similarity 155, member A (ENSG00000204442), score: 0.78 FAM19A1family with sequence similarity 19 (chemokine (C-C motif)-like), member A1 (ENSG00000183662), score: 0.99 FAM19A2family with sequence similarity 19 (chemokine (C-C motif)-like), member A2 (ENSG00000198673), score: 0.91 FAM49Afamily with sequence similarity 49, member A (ENSG00000197872), score: 0.89 FAM5Bfamily with sequence similarity 5, member B (ENSG00000198797), score: 0.92 FAM5Cfamily with sequence similarity 5, member C (ENSG00000162670), score: 0.75 FAM81Afamily with sequence similarity 81, member A (ENSG00000157470), score: 0.82 FAR2fatty acyl CoA reductase 2 (ENSG00000064763), score: 0.75 FAT3FAT tumor suppressor homolog 3 (Drosophila) (ENSG00000165323), score: 0.79 FBLN7fibulin 7 (ENSG00000144152), score: 0.82 FBXL16F-box and leucine-rich repeat protein 16 (ENSG00000127585), score: 0.76 FBXL2F-box and leucine-rich repeat protein 2 (ENSG00000153558), score: 0.78 FEZF2FEZ family zinc finger 2 (ENSG00000153266), score: 0.95 FIG4FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae) (ENSG00000112367), score: 0.75 FLRT2fibronectin leucine rich transmembrane protein 2 (ENSG00000185070), score: 0.82 FOXG1forkhead box G1 (ENSG00000176165), score: 0.84 FREM3FRAS1 related extracellular matrix 3 (ENSG00000183090), score: 0.78 FRMPD4FERM and PDZ domain containing 4 (ENSG00000169933), score: 0.86 FSCN1fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus) (ENSG00000075618), score: 0.81 FSTL4follistatin-like 4 (ENSG00000053108), score: 0.75 GABBR2gamma-aminobutyric acid (GABA) B receptor, 2 (ENSG00000136928), score: 0.79 GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 2 (ENSG00000151834), score: 0.83 GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 4 (ENSG00000109158), score: 0.91 GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 3 (ENSG00000166206), score: 0.77 GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 2 (ENSG00000113327), score: 0.77 GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (ENSG00000136750), score: 0.81 GAP43growth associated protein 43 (ENSG00000172020), score: 0.75 GDAP1L1ganglioside-induced differentiation-associated protein 1-like 1 (ENSG00000124194), score: 0.75 GJD2gap junction protein, delta 2, 36kDa (ENSG00000159248), score: 0.87 GLRA3glycine receptor, alpha 3 (ENSG00000145451), score: 0.89 GLRBglycine receptor, beta (ENSG00000109738), score: 0.77 GNB1guanine nucleotide binding protein (G protein), beta polypeptide 1 (ENSG00000078369), score: 0.77 GNG4guanine nucleotide binding protein (G protein), gamma 4 (ENSG00000168243), score: 0.8 GPR123G protein-coupled receptor 123 (ENSG00000197177), score: 0.87 GPR150G protein-coupled receptor 150 (ENSG00000178015), score: 0.78 GPR26G protein-coupled receptor 26 (ENSG00000154478), score: 0.99 GPR45G protein-coupled receptor 45 (ENSG00000135973), score: 0.84 GPR61G protein-coupled receptor 61 (ENSG00000156097), score: 0.78 GPRIN1G protein regulated inducer of neurite outgrowth 1 (ENSG00000169258), score: 0.74 GRIA2glutamate receptor, ionotropic, AMPA 2 (ENSG00000120251), score: 0.76 GRIA3glutamate receptor, ionotrophic, AMPA 3 (ENSG00000125675), score: 0.88 GRID1glutamate receptor, ionotropic, delta 1 (ENSG00000182771), score: 0.76 GRIK3glutamate receptor, ionotropic, kainate 3 (ENSG00000163873), score: 0.8 GRIK4glutamate receptor, ionotropic, kainate 4 (ENSG00000149403), score: 0.77 GRIN1glutamate receptor, ionotropic, N-methyl D-aspartate 1 (ENSG00000176884), score: 0.77 GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A (ENSG00000183454), score: 0.79 GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B (ENSG00000150086), score: 0.85 GRM2glutamate receptor, metabotropic 2 (ENSG00000164082), score: 0.81 GRM3glutamate receptor, metabotropic 3 (ENSG00000198822), score: 0.79 GSG1LGSG1-like (ENSG00000169181), score: 0.8 GSK3Aglycogen synthase kinase 3 alpha (ENSG00000105723), score: 0.75 HCN1hyperpolarization activated cyclic nucleotide-gated potassium channel 1 (ENSG00000164588), score: 0.77 HMP19HMP19 protein (ENSG00000170091), score: 0.75 HOPXHOP homeobox (ENSG00000171476), score: 0.85 HPCAhippocalcin (ENSG00000121905), score: 0.77 HRH1histamine receptor H1 (ENSG00000196639), score: 0.82 HRH3histamine receptor H3 (ENSG00000101180), score: 0.76 HS3ST2heparan sulfate (glucosamine) 3-O-sulfotransferase 2 (ENSG00000122254), score: 0.96 HS3ST4heparan sulfate (glucosamine) 3-O-sulfotransferase 4 (ENSG00000182601), score: 0.88 HSD11B1Lhydroxysteroid (11-beta) dehydrogenase 1-like (ENSG00000167733), score: 0.75 HTR1A5-hydroxytryptamine (serotonin) receptor 1A (ENSG00000178394), score: 0.99 HTR1B5-hydroxytryptamine (serotonin) receptor 1B (ENSG00000135312), score: 0.91 HTR1E5-hydroxytryptamine (serotonin) receptor 1E (ENSG00000168830), score: 0.89 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (ENSG00000102468), score: 0.99 HTR2C5-hydroxytryptamine (serotonin) receptor 2C (ENSG00000147246), score: 0.89 HTR3B5-hydroxytryptamine (serotonin) receptor 3B (ENSG00000149305), score: 0.76 HTR45-hydroxytryptamine (serotonin) receptor 4 (ENSG00000164270), score: 0.84 HTR65-hydroxytryptamine (serotonin) receptor 6 (ENSG00000158748), score: 0.95 INAinternexin neuronal intermediate filament protein, alpha (ENSG00000148798), score: 0.74 INSM2insulinoma-associated 2 (ENSG00000168348), score: 0.81 IQSEC1IQ motif and Sec7 domain 1 (ENSG00000144711), score: 0.79 ITPKAinositol 1,4,5-trisphosphate 3-kinase A (ENSG00000137825), score: 0.8 JPH3junctophilin 3 (ENSG00000154118), score: 0.75 KCNA4potassium voltage-gated channel, shaker-related subfamily, member 4 (ENSG00000182255), score: 0.84 KCNA6potassium voltage-gated channel, shaker-related subfamily, member 6 (ENSG00000151079), score: 0.94 KCNAB2potassium voltage-gated channel, shaker-related subfamily, beta member 2 (ENSG00000069424), score: 0.79 KCNB1potassium voltage-gated channel, Shab-related subfamily, member 1 (ENSG00000158445), score: 0.82 KCNB2potassium voltage-gated channel, Shab-related subfamily, member 2 (ENSG00000182674), score: 0.96 KCNC2potassium voltage-gated channel, Shaw-related subfamily, member 2 (ENSG00000166006), score: 1 KCNF1potassium voltage-gated channel, subfamily F, member 1 (ENSG00000162975), score: 0.92 KCNG1potassium voltage-gated channel, subfamily G, member 1 (ENSG00000026559), score: 0.85 KCNG3potassium voltage-gated channel, subfamily G, member 3 (ENSG00000171126), score: 0.76 KCNH3potassium voltage-gated channel, subfamily H (eag-related), member 3 (ENSG00000135519), score: 0.91 KCNH4potassium voltage-gated channel, subfamily H (eag-related), member 4 (ENSG00000089558), score: 0.96 KCNH7potassium voltage-gated channel, subfamily H (eag-related), member 7 (ENSG00000184611), score: 0.77 KCNK2potassium channel, subfamily K, member 2 (ENSG00000082482), score: 0.85 KCNN1potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 (ENSG00000105642), score: 0.87 KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 3 (ENSG00000184156), score: 0.95 KCNQ5potassium voltage-gated channel, KQT-like subfamily, member 5 (ENSG00000185760), score: 0.99 KCNS1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1 (ENSG00000124134), score: 0.99 KCNS2potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2 (ENSG00000156486), score: 0.99 KCNV1potassium channel, subfamily V, member 1 (ENSG00000164794), score: 1 KCTD16potassium channel tetramerisation domain containing 16 (ENSG00000183775), score: 0.83 KCTD4potassium channel tetramerisation domain containing 4 (ENSG00000180332), score: 0.91 KIAA0748KIAA0748 (ENSG00000135426), score: 0.99 KIF3Ckinesin family member 3C (ENSG00000084731), score: 0.77 KIRREL3kin of IRRE like 3 (Drosophila) (ENSG00000149571), score: 0.77 KLF11Kruppel-like factor 11 (ENSG00000172059), score: -0.78 KLHL2kelch-like 2, Mayven (Drosophila) (ENSG00000109466), score: 0.79 KNDC1kinase non-catalytic C-lobe domain (KIND) containing 1 (ENSG00000171798), score: 0.74 LATS2LATS, large tumor suppressor, homolog 2 (Drosophila) (ENSG00000150457), score: -0.81 LGI3leucine-rich repeat LGI family, member 3 (ENSG00000168481), score: 0.78 LHX2LIM homeobox 2 (ENSG00000106689), score: 0.85 LIMK1LIM domain kinase 1 (ENSG00000106683), score: 0.79 LMO4LIM domain only 4 (ENSG00000143013), score: 0.93 LMTK2lemur tyrosine kinase 2 (ENSG00000164715), score: 0.79 LNX1ligand of numb-protein X 1 (ENSG00000072201), score: 0.77 LOC401097Similar to LOC166075 (ENSG00000180044), score: 0.82 LPCAT3lysophosphatidylcholine acyltransferase 3 (ENSG00000111684), score: -0.76 LPPR3lipid phosphate phosphatase-related protein type 3 (ENSG00000129951), score: 0.93 LPPR4lipid phosphate phosphatase-related protein type 4 (ENSG00000117600), score: 0.93 LPPR5lipid phosphate phosphatase-related protein type 5 (ENSG00000117598), score: 0.92 LRFN2leucine rich repeat and fibronectin type III domain containing 2 (ENSG00000156564), score: 0.91 LRFN5leucine rich repeat and fibronectin type III domain containing 5 (ENSG00000165379), score: 0.89 LRRC4Cleucine rich repeat containing 4C (ENSG00000148948), score: 0.86 LRRC55leucine rich repeat containing 55 (ENSG00000183908), score: 0.81 LRRC7leucine rich repeat containing 7 (ENSG00000033122), score: 0.78 LRRC8Bleucine rich repeat containing 8 family, member B (ENSG00000197147), score: 0.78 LRRTM2leucine rich repeat transmembrane neuronal 2 (ENSG00000146006), score: 0.78 LRTM2leucine-rich repeats and transmembrane domains 2 (ENSG00000166159), score: 0.98 LY6Hlymphocyte antigen 6 complex, locus H (ENSG00000176956), score: 0.87 MAP2microtubule-associated protein 2 (ENSG00000078018), score: 0.76 MAP2K1mitogen-activated protein kinase kinase 1 (ENSG00000169032), score: 0.82 MAP2K4mitogen-activated protein kinase kinase 4 (ENSG00000065559), score: 0.8 MAPK1mitogen-activated protein kinase 1 (ENSG00000100030), score: 0.84 MAPK3mitogen-activated protein kinase 3 (ENSG00000102882), score: 0.77 MARCH1membrane-associated ring finger (C3HC4) 1 (ENSG00000145416), score: 0.81 MARCH4membrane-associated ring finger (C3HC4) 4 (ENSG00000144583), score: 0.87 MAS1MAS1 oncogene (ENSG00000130368), score: 0.92 MAST3microtubule associated serine/threonine kinase 3 (ENSG00000099308), score: 0.86 MATKmegakaryocyte-associated tyrosine kinase (ENSG00000007264), score: 0.92 MC4Rmelanocortin 4 receptor (ENSG00000166603), score: 0.79 MCHR2melanin-concentrating hormone receptor 2 (ENSG00000152034), score: 0.92 MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 (ENSG00000139915), score: 0.8 MEF2Cmyocyte enhancer factor 2C (ENSG00000081189), score: 0.9 MEPEmatrix extracellular phosphoglycoprotein (ENSG00000152595), score: 0.76 MGAT5Bmannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (ENSG00000167889), score: 0.89 MKL2MKL/myocardin-like 2 (ENSG00000186260), score: 0.93 MMDmonocyte to macrophage differentiation-associated (ENSG00000108960), score: 0.8 MMP17matrix metallopeptidase 17 (membrane-inserted) (ENSG00000198598), score: 0.91 MTPNmyotrophin (ENSG00000105887), score: 0.78 MYO5Amyosin VA (heavy chain 12, myoxin) (ENSG00000197535), score: 0.76 MYT1Lmyelin transcription factor 1-like (ENSG00000186487), score: 0.75 NCALDneurocalcin delta (ENSG00000104490), score: 0.91 NCAM2neural cell adhesion molecule 2 (ENSG00000154654), score: 0.78 NCANneurocan (ENSG00000130287), score: 0.86 NCDNneurochondrin (ENSG00000020129), score: 0.79 NCS1neuronal calcium sensor 1 (ENSG00000107130), score: 0.75 NECAB1N-terminal EF-hand calcium binding protein 1 (ENSG00000123119), score: 0.94 NEFLneurofilament, light polypeptide (ENSG00000104725), score: 0.85 NEFMneurofilament, medium polypeptide (ENSG00000104722), score: 0.76 NELFnasal embryonic LHRH factor (ENSG00000165802), score: 0.82 NELL2NEL-like 2 (chicken) (ENSG00000184613), score: 0.8 NETO1neuropilin (NRP) and tolloid (TLL)-like 1 (ENSG00000166342), score: 0.98 NEUROD6neurogenic differentiation 6 (ENSG00000164600), score: 0.96 NFATC3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 (ENSG00000072736), score: -0.75 NGBneuroglobin (ENSG00000165553), score: 0.92 NGEFneuronal guanine nucleotide exchange factor (ENSG00000066248), score: 0.82 NLKnemo-like kinase (ENSG00000087095), score: 0.88 NOGnoggin (ENSG00000183691), score: 0.77 NOVA2neuro-oncological ventral antigen 2 (ENSG00000104967), score: 0.76 NPAS1neuronal PAS domain protein 1 (ENSG00000130751), score: 0.93 NPBWR2neuropeptides B/W receptor 2 (ENSG00000125522), score: 0.89 NPTNneuroplastin (ENSG00000156642), score: 0.75 NPY2Rneuropeptide Y receptor Y2 (ENSG00000185149), score: 0.85 NRCAMneuronal cell adhesion molecule (ENSG00000091129), score: 0.79 NRG3neuregulin 3 (ENSG00000185737), score: 0.97 NRSN1neurensin 1 (ENSG00000152954), score: 0.89 NSFN-ethylmaleimide-sensitive factor (ENSG00000073969), score: 0.84 NT5DC35'-nucleotidase domain containing 3 (ENSG00000111696), score: 0.74 NTNG2netrin G2 (ENSG00000196358), score: 0.77 NTRK2neurotrophic tyrosine kinase, receptor, type 2 (ENSG00000148053), score: 0.74 NTSR2neurotensin receptor 2 (ENSG00000169006), score: 0.74 NUAK1NUAK family, SNF1-like kinase, 1 (ENSG00000074590), score: 0.76 OLFM1olfactomedin 1 (ENSG00000130558), score: 0.79 OPALINoligodendrocytic myelin paranodal and inner loop protein (ENSG00000197430), score: 0.77 OPRD1opioid receptor, delta 1 (ENSG00000116329), score: 0.98 OPRL1opiate receptor-like 1 (ENSG00000125510), score: 0.76 OTX1orthodenticle homeobox 1 (ENSG00000115507), score: 0.76 P2RY12purinergic receptor P2Y, G-protein coupled, 12 (ENSG00000169313), score: 0.76 PCDH10protocadherin 10 (ENSG00000138650), score: 0.8 PCDH19protocadherin 19 (ENSG00000165194), score: 0.97 PCDH20protocadherin 20 (ENSG00000197991), score: 0.87 PCDH8protocadherin 8 (ENSG00000136099), score: 0.96 PCDH9protocadherin 9 (ENSG00000184226), score: 0.8 PCSK1proprotein convertase subtilisin/kexin type 1 (ENSG00000175426), score: 0.99 PCSK2proprotein convertase subtilisin/kexin type 2 (ENSG00000125851), score: 0.81 PDE1Bphosphodiesterase 1B, calmodulin-dependent (ENSG00000123360), score: 0.85 PDE2Aphosphodiesterase 2A, cGMP-stimulated (ENSG00000186642), score: 0.83 PDE8Bphosphodiesterase 8B (ENSG00000113231), score: 0.9 PDYNprodynorphin (ENSG00000101327), score: 0.87 PEX5Lperoxisomal biogenesis factor 5-like (ENSG00000114757), score: 0.87 PGM2L1phosphoglucomutase 2-like 1 (ENSG00000165434), score: 0.88 PHACTR1phosphatase and actin regulator 1 (ENSG00000112137), score: 0.75 PIP5KL1phosphatidylinositol-4-phosphate 5-kinase-like 1 (ENSG00000167103), score: 0.78 PITPNAphosphatidylinositol transfer protein, alpha (ENSG00000174238), score: 0.75 PLCB1phospholipase C, beta 1 (phosphoinositide-specific) (ENSG00000182621), score: 0.85 PLD3phospholipase D family, member 3 (ENSG00000105223), score: 0.78 PNCKpregnancy up-regulated non-ubiquitously expressed CaM kinase (ENSG00000130822), score: 0.86 PNMAL2PNMA-like 2 (ENSG00000204851), score: 0.86 PNOCprepronociceptin (ENSG00000168081), score: 0.94 POLR3Apolymerase (RNA) III (DNA directed) polypeptide A, 155kDa (ENSG00000148606), score: 0.75 PPFIA2protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 (ENSG00000139220), score: 0.78 PPME1protein phosphatase methylesterase 1 (ENSG00000214517), score: 0.75 PPP3CBprotein phosphatase 3, catalytic subunit, beta isozyme (ENSG00000107758), score: 0.74 PRDM8PR domain containing 8 (ENSG00000152784), score: 0.86 PRICKLE2prickle homolog 2 (Drosophila) (ENSG00000163637), score: 0.88 PRKAR1Bprotein kinase, cAMP-dependent, regulatory, type I, beta (ENSG00000188191), score: 0.74 PRKCAprotein kinase C, alpha (ENSG00000154229), score: 0.81 PRKCBprotein kinase C, beta (ENSG00000166501), score: 0.81 PRKCEprotein kinase C, epsilon (ENSG00000171132), score: 0.74 PRKCGprotein kinase C, gamma (ENSG00000126583), score: 0.78 PRKG2protein kinase, cGMP-dependent, type II (ENSG00000138669), score: 0.83 PRMT8protein arginine methyltransferase 8 (ENSG00000111218), score: 0.79 PROKR2prokineticin receptor 2 (ENSG00000101292), score: 0.81 PRR7proline rich 7 (synaptic) (ENSG00000131188), score: 0.79 PRRG3proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane) (ENSG00000130032), score: 0.83 PSDpleckstrin and Sec7 domain containing (ENSG00000059915), score: 0.8 PSRC1proline/serine-rich coiled-coil 1 (ENSG00000134222), score: 0.79 PTPN5protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) (ENSG00000110786), score: 0.9 PTPRNprotein tyrosine phosphatase, receptor type, N (ENSG00000054356), score: 0.81 R3HDM1R3H domain containing 1 (ENSG00000048991), score: 0.79 RAB3BRAB3B, member RAS oncogene family (ENSG00000169213), score: 0.77 RAB3CRAB3C, member RAS oncogene family (ENSG00000152932), score: 0.77 RAB6BRAB6B, member RAS oncogene family (ENSG00000154917), score: 0.78 RAPGEF4Rap guanine nucleotide exchange factor (GEF) 4 (ENSG00000091428), score: 0.74 RAPGEF5Rap guanine nucleotide exchange factor (GEF) 5 (ENSG00000136237), score: 0.78 RAPGEFL1Rap guanine nucleotide exchange factor (GEF)-like 1 (ENSG00000108352), score: 0.75 RASD2RASD family, member 2 (ENSG00000100302), score: 0.81 RASL10ARAS-like, family 10, member A (ENSG00000100276), score: 0.88 RGS20regulator of G-protein signaling 20 (ENSG00000147509), score: 0.75 RGS4regulator of G-protein signaling 4 (ENSG00000117152), score: 0.97 RHBDD2rhomboid domain containing 2 (ENSG00000005486), score: 0.77 RHEBL1Ras homolog enriched in brain like 1 (ENSG00000167550), score: 0.84 RIMBP2RIMS binding protein 2 (ENSG00000060709), score: 0.88 RIMS3regulating synaptic membrane exocytosis 3 (ENSG00000117016), score: 0.79 RNF11ring finger protein 11 (ENSG00000123091), score: 0.79 RNF24ring finger protein 24 (ENSG00000101236), score: 0.76 RORBRAR-related orphan receptor B (ENSG00000198963), score: 0.91 RPRMreprimo, TP53 dependent G2 arrest mediator candidate (ENSG00000177519), score: 0.85 RPRMLreprimo-like (ENSG00000179673), score: 0.79 RRAGARas-related GTP binding A (ENSG00000155876), score: 0.75 RSPO2R-spondin 2 homolog (Xenopus laevis) (ENSG00000147655), score: 0.92 RTBDNretbindin (ENSG00000132026), score: 0.84 RTN2reticulon 2 (ENSG00000125744), score: 0.76 RTN3reticulon 3 (ENSG00000133318), score: 0.81 RTN4RL1reticulon 4 receptor-like 1 (ENSG00000185924), score: 0.75 RXFP1relaxin/insulin-like family peptide receptor 1 (ENSG00000171509), score: 0.8 SARSseryl-tRNA synthetase (ENSG00000031698), score: 0.75 SATB2SATB homeobox 2 (ENSG00000119042), score: 0.93 SCG2secretogranin II (ENSG00000171951), score: 0.88 SCN1Asodium channel, voltage-gated, type I, alpha subunit (ENSG00000144285), score: 0.82 SCN3Asodium channel, voltage-gated, type III, alpha subunit (ENSG00000153253), score: 0.77 SCN3Bsodium channel, voltage-gated, type III, beta (ENSG00000166257), score: 0.94 SEC14L5SEC14-like 5 (S. cerevisiae) (ENSG00000103184), score: 0.79 SEMA3Asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A (ENSG00000075213), score: 0.83 SERPINI1serpin peptidase inhibitor, clade I (neuroserpin), member 1 (ENSG00000163536), score: 0.9 SGIP1SH3-domain GRB2-like (endophilin) interacting protein 1 (ENSG00000118473), score: 0.77 SGSM2small G protein signaling modulator 2 (ENSG00000141258), score: 0.79 SGTBsmall glutamine-rich tetratricopeptide repeat (TPR)-containing, beta (ENSG00000197860), score: 0.81 SH2D5SH2 domain containing 5 (ENSG00000189410), score: 0.93 SHANK1SH3 and multiple ankyrin repeat domains 1 (ENSG00000161681), score: 0.75 SHC3SHC (Src homology 2 domain containing) transforming protein 3 (ENSG00000148082), score: 0.91 SLC10A4solute carrier family 10 (sodium/bile acid cotransporter family), member 4 (ENSG00000145248), score: 0.85 SLC17A7solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 (ENSG00000104888), score: 0.76 SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 2 (ENSG00000110436), score: 0.75 SLC24A2solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 (ENSG00000155886), score: 0.76 SLC24A4solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (ENSG00000140090), score: 0.82 SLC32A1solute carrier family 32 (GABA vesicular transporter), member 1 (ENSG00000101438), score: 0.79 SLC35F1solute carrier family 35, member F1 (ENSG00000196376), score: 0.78 SLC39A10solute carrier family 39 (zinc transporter), member 10 (ENSG00000196950), score: 0.85 SLC39A12solute carrier family 39 (zinc transporter), member 12 (ENSG00000148482), score: 0.78 SLC4A10solute carrier family 4, sodium bicarbonate transporter, member 10 (ENSG00000144290), score: 0.79 SLC6A17solute carrier family 6, member 17 (ENSG00000197106), score: 0.76 SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 (ENSG00000011083), score: 0.81 SLC8A3solute carrier family 8 (sodium/calcium exchanger), member 3 (ENSG00000100678), score: 0.8 SLC9A6solute carrier family 9 (sodium/hydrogen exchanger), member 6 (ENSG00000198689), score: 0.81 SLCO1C1solute carrier organic anion transporter family, member 1C1 (ENSG00000139155), score: 0.77 SLIT1slit homolog 1 (Drosophila) (ENSG00000187122), score: 0.96 SLITRK1SLIT and NTRK-like family, member 1 (ENSG00000178235), score: 0.91 SLITRK2SLIT and NTRK-like family, member 2 (ENSG00000185985), score: 0.79 SLITRK3SLIT and NTRK-like family, member 3 (ENSG00000121871), score: 0.8 SLITRK5SLIT and NTRK-like family, member 5 (ENSG00000165300), score: 0.86 SNTG1syntrophin, gamma 1 (ENSG00000147481), score: 0.87 SP1Sp1 transcription factor (ENSG00000185591), score: -0.85 SPIN1spindlin 1 (ENSG00000106723), score: 0.76 SPRED3sprouty-related, EVH1 domain containing 3 (ENSG00000188766), score: 0.79 SSTsomatostatin (ENSG00000157005), score: 0.92 ST6GAL2ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 (ENSG00000144057), score: 0.75 ST6GALNAC5ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ENSG00000117069), score: 0.95 STK32Cserine/threonine kinase 32C (ENSG00000165752), score: 0.87 STOML1stomatin (EPB72)-like 1 (ENSG00000067221), score: 0.79 STX1Asyntaxin 1A (brain) (ENSG00000106089), score: 0.82 STYK1serine/threonine/tyrosine kinase 1 (ENSG00000060140), score: 0.97 SULT4A1sulfotransferase family 4A, member 1 (ENSG00000130540), score: 0.77 SVOPSV2 related protein homolog (rat) (ENSG00000166111), score: 0.78 SYNGAP1synaptic Ras GTPase activating protein 1 (ENSG00000197283), score: 0.78 SYNGR3synaptogyrin 3 (ENSG00000127561), score: 0.78 SYNJ1synaptojanin 1 (ENSG00000159082), score: 0.78 SYPsynaptophysin (ENSG00000102003), score: 0.77 SYT1synaptotagmin I (ENSG00000067715), score: 0.77 SYT17synaptotagmin XVII (ENSG00000103528), score: 0.82 SYT5synaptotagmin V (ENSG00000129990), score: 0.87 TAC1tachykinin, precursor 1 (ENSG00000006128), score: 0.77 TBR1T-box, brain, 1 (ENSG00000136535), score: 0.98 TCERG1Ltranscription elongation regulator 1-like (ENSG00000176769), score: 0.77 THRBthyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) (ENSG00000151090), score: 0.74 THY1Thy-1 cell surface antigen (ENSG00000154096), score: 0.77 TMEFF2transmembrane protein with EGF-like and two follistatin-like domains 2 (ENSG00000144339), score: 0.79 TMEM130transmembrane protein 130 (ENSG00000166448), score: 0.77 TMEM132Dtransmembrane protein 132D (ENSG00000151952), score: 0.98 TMEM151Atransmembrane protein 151A (ENSG00000179292), score: 0.79 TMEM155transmembrane protein 155 (ENSG00000164112), score: 0.98 TMEM196transmembrane protein 196 (ENSG00000173452), score: 0.94 TMEM39Atransmembrane protein 39A (ENSG00000176142), score: -0.76 TMEM59Ltransmembrane protein 59-like (ENSG00000105696), score: 0.74 TMEM66transmembrane protein 66 (ENSG00000133872), score: 0.78 TOXthymocyte selection-associated high mobility group box (ENSG00000198846), score: 0.81 TRPC5transient receptor potential cation channel, subfamily C, member 5 (ENSG00000072315), score: 0.8 TRPM2transient receptor potential cation channel, subfamily M, member 2 (ENSG00000142185), score: 0.85 TSHZ3teashirt zinc finger homeobox 3 (ENSG00000121297), score: 0.77 UCHL1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (ENSG00000154277), score: 0.77 UNC5Aunc-5 homolog A (C. elegans) (ENSG00000113763), score: 0.79 UNC5Dunc-5 homolog D (C. elegans) (ENSG00000156687), score: 0.79 USP3ubiquitin specific peptidase 3 (ENSG00000140455), score: -0.75 VAMP1vesicle-associated membrane protein 1 (synaptobrevin 1) (ENSG00000139190), score: 0.76 VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2) (ENSG00000220205), score: 0.76 VGFVGF nerve growth factor inducible (ENSG00000128564), score: 0.9 VIPvasoactive intestinal peptide (ENSG00000146469), score: 0.9 VSTM2AV-set and transmembrane domain containing 2A (ENSG00000170419), score: 0.99 VSTM2BV-set and transmembrane domain containing 2B (ENSG00000187135), score: 0.83 VSTM2LV-set and transmembrane domain containing 2 like (ENSG00000132821), score: 0.84 VWC2Lvon Willebrand factor C domain-containing protein 2-like (ENSG00000174453), score: 0.89 WDR7WD repeat domain 7 (ENSG00000091157), score: 0.79 WDR92WD repeat domain 92 (ENSG00000221823), score: 0.78 WEE1WEE1 homolog (S. pombe) (ENSG00000166483), score: -0.74 WNT1wingless-type MMTV integration site family, member 1 (ENSG00000125084), score: 0.76 WNT10Bwingless-type MMTV integration site family, member 10B (ENSG00000169884), score: 0.95 WNT7Awingless-type MMTV integration site family, member 7A (ENSG00000154764), score: 0.82 WSB2WD repeat and SOCS box-containing 2 (ENSG00000176871), score: 0.76 XKR4XK, Kell blood group complex subunit-related family, member 4 (ENSG00000206579), score: 0.81 YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (ENSG00000170027), score: 0.8 YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (ENSG00000128245), score: 0.8 ZC3H12Bzinc finger CCCH-type containing 12B (ENSG00000102053), score: 0.81 ZDHHC22zinc finger, DHHC-type containing 22 (ENSG00000177108), score: 0.85 ZFR2zinc finger RNA binding protein 2 (ENSG00000105278), score: 0.77 ZMAT4zinc finger, matrin type 4 (ENSG00000165061), score: 0.93 ZNF365zinc finger protein 365 (ENSG00000138311), score: 0.84
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| ptr_br_f_ca1 | ptr | br | f | _ |
| hsa_br_m1_ca1 | hsa | br | m | 1 |
| ptr_br_m3_ca1 | ptr | br | m | 3 |
| ptr_br_m2_ca1 | ptr | br | m | 2 |
| ggo_br_m_ca1 | ggo | br | m | _ |
| ptr_br_m5_ca1 | ptr | br | m | 5 |
| ptr_br_m1_ca1 | ptr | br | m | 1 |
| hsa_br_f_ca1 | hsa | br | f | _ |
| ggo_br_f_ca1 | ggo | br | f | _ |
| ppa_br_f1_ca1 | ppa | br | f | 1 |
| ppa_br_m_ca1 | ppa | br | m | _ |
| ppy_br_f_ca1 | ppy | br | f | _ |
| hsa_br_m2_ca1 | hsa | br | m | 2 |
| hsa_br_m3_ca1 | hsa | br | m | 3 |
| ptr_br_m4_ca1 | ptr | br | m | 4 |
| mml_br_m1_ca1 | mml | br | m | 1 |
| mml_br_f_ca1 | mml | br | f | _ |
| hsa_br_m7_ca1 | hsa | br | m | 7 |
| ppy_br_m_ca1 | ppy | br | m | _ |
| mml_br_m2_ca1 | mml | br | m | 2 |
