Under-expression is coded with green,
over-expression with red color.
system process
A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.
cellular ion homeostasis
Any process involved in the maintenance of an internal steady-state of ions at the level of a cell.
cell communication
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
cell surface receptor linked signaling pathway
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
glutamate signaling pathway
The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
synaptic transmission
The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
embryo development
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
nervous system development
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
neurological system process
A organ system process carried out by any of the organs or tissues of neurological system.
central nervous system development
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
brain development
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
cellular process
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
cellular homeostasis
Any process involved in the maintenance of an internal steady-state at the level of the cell.
neurogenesis
Generation of cells within the nervous system.
signaling pathway
The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms.
signaling process
Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.
signaling
The entirety of a process whereby information is transmitted. This process begins with the initiation of the signal and ends when a response has been triggered.
signal transmission
The process whereby a signal is released and/or conveyed from one location to another.
cell differentiation
The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
neuron differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a neuron.
midbrain development
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
multicellular organismal process
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
developmental process
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
regulation of membrane potential
Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
homeostatic process
Any biological process involved in the maintenance of an internal steady-state.
ion homeostasis
Any process involved in the maintenance of an internal steady-state of ions within an organism or cell.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
embryonic morphogenesis
The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
generation of neurons
The process by which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
anatomical structure development
The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical.
membrane depolarization
The process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.
cellular chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical at the level of the cell.
regulation of postsynaptic membrane potential
Any process that modulates the establishment or extent of the postsynaptic membrane potential, which is generated by changes in the membrane potential of the post synaptic neuron that receives information at a synapse. The presynaptic neuron releases neurotransmitters into the synaptic cleft which bind to receptors on the postsynaptic neuron. After being bound by the neurotransmitters, these receptors can open or close an ion channel, allowing ions to enter or leave the cell and therefore altering the membrane potential of the postsynaptic neuron.
regulation of excitatory postsynaptic membrane potential
Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
biological regulation
Any process that modulates the frequency, rate or extent of any biological process, quality or function.
regulation of biological quality
Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.
all
NA
signaling process
Any biological process involved in the generation, transmission, reception, or interpretation of a signal. A signal is an entity used to transmit or convey information.
multicellular organismal development
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
cellular developmental process
A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
cell-cell signaling
Any process that mediates the transfer of information from one cell to another.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
embryo development
The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.
embryonic morphogenesis
The process by which anatomical structures are generated and organized during the embryonic phase. Morphogenesis pertains to the creation of form. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
anatomical structure morphogenesis
The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
system development
The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
synaptic transmission
The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
transmission of nerve impulse
The neurological system process by which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.
organ development
Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
cellular homeostasis
Any process involved in the maintenance of an internal steady-state at the level of the cell.
central nervous system development
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
neurogenesis
Generation of cells within the nervous system.
brain development
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
midbrain development
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
cellular chemical homeostasis
Any biological process involved in the maintenance of an internal steady-state of a chemical at the level of the cell.
regulation of postsynaptic membrane potential
Any process that modulates the establishment or extent of the postsynaptic membrane potential, which is generated by changes in the membrane potential of the post synaptic neuron that receives information at a synapse. The presynaptic neuron releases neurotransmitters into the synaptic cleft which bind to receptors on the postsynaptic neuron. After being bound by the neurotransmitters, these receptors can open or close an ion channel, allowing ions to enter or leave the cell and therefore altering the membrane potential of the postsynaptic neuron.
neuron differentiation
The process whereby a relatively unspecialized cell acquires specialized features of a neuron.
cellular ion homeostasis
Any process involved in the maintenance of an internal steady-state of ions at the level of a cell.
regulation of excitatory postsynaptic membrane potential
Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
outer membrane-bounded periplasmic space
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall.
external encapsulating structure
A structure that lies outside the plasma membrane and surrounds the entire cell.
cell envelope
An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.
envelope
A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.
periplasmic space
The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or inner membrane and cell wall (Fungi).
external encapsulating structure part
Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
synapse
The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
all
NA
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
external encapsulating structure part
Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell.
outer membrane-bounded periplasmic space
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall.
outer membrane-bounded periplasmic space
The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
nucleic acid binding
Interacting selectively and non-covalently with any nucleic acid.
DNA binding
Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid).
sequence-specific DNA binding transcription factor activity
Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
binding
The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
glutamate receptor activity
Combining with glutamate to initiate a change in cell activity.
sequence-specific DNA binding
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
NA
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 04080 | 4.740e-02 | 0.6444 | 4 | 206 | Neuroactive ligand-receptor interaction |
BARHL1BarH-like homeobox 1 (ENSG00000125492), score: 0.98 BARHL2BarH-like homeobox 2 (ENSG00000143032), score: 0.96 C20orf117chromosome 20 open reading frame 117 (ENSG00000149639), score: 0.78 CBLN1cerebellin 1 precursor (ENSG00000102924), score: 0.91 CBLN3cerebellin 3 precursor (ENSG00000139899), score: 0.88 CDH15cadherin 15, type 1, M-cadherin (myotubule) (ENSG00000129910), score: 1 CDH7cadherin 7, type 2 (ENSG00000081138), score: 0.81 CDONCdon homolog (mouse) (ENSG00000064309), score: 0.79 CERKLceramide kinase-like (ENSG00000188452), score: 0.79 CHD7chromodomain helicase DNA binding protein 7 (ENSG00000171316), score: 0.89 CHRNA3cholinergic receptor, nicotinic, alpha 3 (ENSG00000080644), score: 0.78 CNPY1canopy 1 homolog (zebrafish) (ENSG00000146910), score: 0.96 COL13A1collagen, type XIII, alpha 1 (ENSG00000197467), score: 0.81 CRTAMcytotoxic and regulatory T cell molecule (ENSG00000109943), score: 1 EN2engrailed homeobox 2 (ENSG00000164778), score: 0.96 EOMESeomesodermin (ENSG00000163508), score: 0.91 EXPH5exophilin 5 (ENSG00000110723), score: 0.88 FAT2FAT tumor suppressor homolog 2 (Drosophila) (ENSG00000086570), score: 0.96 FGF5fibroblast growth factor 5 (ENSG00000138675), score: 0.86 FSTL5follistatin-like 5 (ENSG00000168843), score: 0.81 GPRIN3GPRIN family member 3 (ENSG00000185477), score: 0.78 GRID2glutamate receptor, ionotropic, delta 2 (ENSG00000152208), score: 0.84 GRID2IPglutamate receptor, ionotropic, delta 2 (Grid2) interacting protein (ENSG00000215045), score: 0.89 GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C (ENSG00000161509), score: 0.79 GRM4glutamate receptor, metabotropic 4 (ENSG00000124493), score: 0.93 IL16interleukin 16 (lymphocyte chemoattractant factor) (ENSG00000172349), score: 0.89 KCNK9potassium channel, subfamily K, member 9 (ENSG00000169427), score: 0.79 KDM4Clysine (K)-specific demethylase 4C (ENSG00000107077), score: 0.83 KIAA0802KIAA0802 (ENSG00000168502), score: 0.83 LBX1ladybird homeobox 1 (ENSG00000138136), score: 0.9 LHX5LIM homeobox 5 (ENSG00000089116), score: 0.96 LOC146429putative solute carrier family 22 member ENSG00000182157 (ENSG00000182157), score: 0.93 MAB21L1mab-21-like 1 (C. elegans) (ENSG00000180660), score: 0.97 MAML3mastermind-like 3 (Drosophila) (ENSG00000196782), score: 0.86 MDGA1MAM domain containing glycosylphosphatidylinositol anchor 1 (ENSG00000112139), score: 0.89 NHLH2nescient helix loop helix 2 (ENSG00000177551), score: 0.87 NKX6-3NK6 homeobox 3 (ENSG00000165066), score: 0.86 ODZ1odz, odd Oz/ten-m homolog 1(Drosophila) (ENSG00000009694), score: 0.83 OTX2orthodenticle homeobox 2 (ENSG00000165588), score: 0.91 PAX6paired box 6 (ENSG00000007372), score: 0.78 PAXIP1PAX interacting (with transcription-activation domain) protein 1 (ENSG00000157212), score: 0.79 PISDphosphatidylserine decarboxylase (ENSG00000241878), score: 0.81 PKIBprotein kinase (cAMP-dependent, catalytic) inhibitor beta (ENSG00000135549), score: 0.88 PTCH1patched 1 (ENSG00000185920), score: 0.78 PTCHD1patched domain containing 1 (ENSG00000165186), score: 0.86 RCAN3RCAN family member 3 (ENSG00000117602), score: 0.82 SLC35F4solute carrier family 35, member F4 (ENSG00000151812), score: 0.95 SPTBN5spectrin, beta, non-erythrocytic 5 (ENSG00000137877), score: 0.82 TIAM1T-cell lymphoma invasion and metastasis 1 (ENSG00000156299), score: 0.81 TLL1tolloid-like 1 (ENSG00000038295), score: 0.93 TRIM67tripartite motif-containing 67 (ENSG00000119283), score: 0.87 UBASH3Bubiquitin associated and SH3 domain containing B (ENSG00000154127), score: 0.8 VSX1visual system homeobox 1 (ENSG00000100987), score: 0.8 XKR7XK, Kell blood group complex subunit-related family, member 7 (ENSG00000101321), score: 0.87 ZIC2Zic family member 2 (odd-paired homolog, Drosophila) (ENSG00000043355), score: 0.85 ZIC4Zic family member 4 (ENSG00000174963), score: 0.98 ZIC5Zic family member 5 (odd-paired homolog, Drosophila) (ENSG00000139800), score: 0.83 ZNF157zinc finger protein 157 (ENSG00000147117), score: 0.86 ZNF296zinc finger protein 296 (ENSG00000170684), score: 0.78 ZNF521zinc finger protein 521 (ENSG00000198795), score: 0.86
| Id | species | tissue | sex | individual |
|---|---|---|---|---|
| ggo_cb_m_ca1 | ggo | cb | m | _ |
| ptr_cb_f_ca1 | ptr | cb | f | _ |
| mml_cb_f_ca1 | mml | cb | f | _ |
| mml_cb_m_ca1 | mml | cb | m | _ |
| ppy_cb_f_ca1 | ppy | cb | f | _ |
| ppa_cb_f_ca1 | ppa | cb | f | _ |
| ggo_cb_f_ca1 | ggo | cb | f | _ |
| ppa_cb_m_ca1 | ppa | cb | m | _ |
| ptr_cb_m_ca1 | ptr | cb | m | _ |
| hsa_cb_m_ca1 | hsa | cb | m | _ |
| hsa_cb_f_ca1 | hsa | cb | f | _ |
