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renal system process involved in regulation of blood volume

A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.

system process

A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.

circulatory system process

A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.

renal system process

A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism.

renal system process involved in regulation of systemic arterial blood pressure

Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

regulation of systemic arterial blood pressure

The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

renal water transport

The directed movement of water (H2O) by the kidney.

secretion

The controlled release of a substance by a cell, a group of cells, or a tissue.

transport

The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore.

ion transport

The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore.

cation transport

The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

anion transport

The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

metal ion transport

The directed movement of metal ions, any metal ion with an electric charge, into, out of, within or between cells by means of some external agent such as a transporter or pore.

water transport

The directed movement of water (H2O) into, out of, within or between cells by means of some external agent such as a transporter or pore.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

blood circulation

The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

carbohydrate transport

The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

monovalent inorganic cation transport

The directed movement of inorganic cations with a valency of one into, out of, within or between cells by means of some external agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.

organic cation transport

The directed movement of organic cations into, out of, within or between cells by means of some external agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.

ammonium transport

The directed movement of ammonium into, out of, within or between cells by means of some external agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.

polyol transport

The directed movement of polyols, any polyhydric alcohol, into, out of, within or between cells by means of some external agent such as a transporter or pore.

glycerol transport

The directed movement of glycerol into, out of, within or between cells by means of some external agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

organic alcohol transport

The directed movement of organic alcohols into, out of, within or between cells by means of some external agent such as a transporter or pore. An organic alcohol is any carbon-containing compound containing a hydroxyl group.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

fluid transport

The directed movement of substances that are in liquid form in normal living conditions into, out of, within or between cells by means of some external agent such as a transporter or pore.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

regulation of biological quality

Any process that modulates the frequency, rate or extent of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.

all

NA

establishment of localization

The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location.

transmembrane transport

The process whereby a solute is transported from one side of a membrane to the other. This process includes the actual movement of the solute, and any regulation and preparatory steps, such as reduction of the solute.

regulation of body fluid levels

Any process that modulates the levels of body fluids.

renal water transport

The directed movement of water (H2O) by the kidney.

excretion

The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.

regulation of blood pressure

Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

renal system process involved in regulation of blood volume

A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.

glycerol transport

The directed movement of glycerol into, out of, within or between cells by means of some external agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

renal water transport

The directed movement of water (H2O) by the kidney.

renal system process involved in regulation of systemic arterial blood pressure

Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.

sodium ion transport

The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

intracellular

The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

integral to membrane

Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

cytoplasm

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

brush border

Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.

basolateral plasma membrane

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

organelle membrane

The lipid bilayer surrounding an organelle.

intrinsic to membrane

Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.

cell projection

A prolongation or process extending from a cell, e.g. a flagellum or axon.

organelle

Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.

membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

apical part of cell

The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.

all

NA

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

organelle part

Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.

organelle membrane

The lipid bilayer surrounding an organelle.

intracellular membrane-bounded organelle

Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

intracellular part

Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.

organelle membrane

The lipid bilayer surrounding an organelle.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

cell projection part

Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.

intracellular organelle

Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.

intracellular organelle part

A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.

proton-transporting two-sector ATPase complex

A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible.

vacuolar membrane

The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cytoplasmic part

Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

vacuole

A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

apical plasma membrane

The region of the plasma membrane located at the apical end of the cell.

intrinsic to plasma membrane

Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached moiety such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.

cell projection membrane

The portion of the plasma membrane surrounding a cell surface projection.

brush border membrane

The portion of the plasma membrane surrounding the brush border.

vacuolar proton-transporting V-type ATPase complex

A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen.

vacuolar part

Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.

integral to plasma membrane

Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.

protein binding

Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

metal ion transmembrane transporter activity

Catalysis of the transfer of metal ions from one side of a membrane to the other.

dipeptidase activity

Catalysis of the hydrolysis of a dipeptide.

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

phospholipase activity

Catalysis of the hydrolysis of a glycerophospholipid.

sphingomyelin phosphodiesterase activity

Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.

transporter activity

Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

sodium channel activity

Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

transmembrane transporter activity

Enables the transfer of a substance from one side of a membrane to the other.

secondary active transmembrane transporter activity

Catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.

inorganic anion exchanger activity

NA

binding

The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

phosphoric diester hydrolase activity

Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.

cytoskeletal protein binding

Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).

exopeptidase activity

Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.

cation transmembrane transporter activity

Catalysis of the transfer of cation from one side of the membrane to the other.

anion transmembrane transporter activity

Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.

peptidase activity, acting on L-amino acid peptides

Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.

ion transmembrane transporter activity

Catalysis of the transfer of an ion from one side of a membrane to the other.

monovalent inorganic cation transmembrane transporter activity

Catalysis of the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

potassium ion transmembrane transporter activity

Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other.

polyol transmembrane transporter activity

Catalysis of the transfer of a polyol from one side of the membrane to the other. A polyol is any polyhydric alcohol.

glycerol transmembrane transporter activity

Catalysis of the transfer of glycerol from one side of the membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.

channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

amiloride-sensitive sodium channel activity

NA

symporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

antiporter activity

Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

solute:solute antiporter activity

Catalysis of the reaction: solute A(out) + solute B(in) = solute A(in) + solute B(out).

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

anion exchanger activity

NA

alcohol transmembrane transporter activity

Catalysis of the transfer of an alcohol from one side of the membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group.

lipase activity

Catalysis of the hydrolysis of a lipid or phospholipid.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

hydrolase activity, acting on ester bonds

Catalysis of the hydrolysis of any ester bond.

passive transmembrane transporter activity

Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient.

active transmembrane transporter activity

Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.

ligand-gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

gated channel activity

Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

inorganic cation transmembrane transporter activity

Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific transporter activity

Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of, within or between cells.

ankyrin binding

Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.

phosphoric ester hydrolase activity

Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.

ammonia transmembrane transporter activity

Enables the directed movement of ammonia from one side of the membrane to the other.

all

NA

substrate-specific transmembrane transporter activity

Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.

substrate-specific channel activity

Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.

ion channel activity

Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.

sphingomyelin phosphodiesterase activity

Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate.

cation channel activity

Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient.

ligand-gated ion channel activity

Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.

anion:anion antiporter activity

Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out).

amiloride-sensitive sodium channel activity

NA

potassium ion transmembrane transporter activity

Catalysis of the transfer of potassium ions (K+) from one side of a membrane to the other.

Id	Pvalue	ExpCount	Count	Size	Term
GO:0006811	9.621e-10	13.16	43 ANO10, AQP1, AQP2, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, CALCA, CLCNKA, CYP27B1, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, PRSS8, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC4A1, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4, TRPC7, VDR	663	ion transport
GO:0006812	1.657e-08	9.489	34 AQP1, AQP2, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, CALCA, CYP27B1, FXYD2, KCNE3, KCNJ1, KCNK5, PRSS8, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC22A13, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4, TRPC7, VDR	478	cation transport
GO:0007588	2.525e-07	0.933	11 AQP2, AQP3, ATP6V0A4, ATP6V1B1, CLCNKA, KCNJ1, KCNK5, NPHS2, SCNN1A, SCNN1B, SCNN1G	47	excretion
GO:0015672	9.249e-07	5.042	22 AQP1, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, FXYD2, KCNE3, KCNJ1, KCNK5, PRSS8, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC34A1, SLC34A3, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4	254	monovalent inorganic cation transport
GO:0030001	1.377e-06	8.139	28 AQP1, AQP2, ATP12A, ATP4B, CALCA, CYP27B1, FXYD2, KCNE3, KCNJ1, KCNK5, PRSS8, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4, TRPC7, VDR	410	metal ion transport
GO:0006814	8.714e-06	2.323	14 ATP4B, FXYD2, PRSS8, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC34A1, SLC34A3, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC9A4	117	sodium ion transport
GO:0055085	3.408e-04	11.65	29 AQP1, AQP2, AQP3, ATP6V0A4, ATP6V0D2, ATP6V1B1, CLCNKA, KCNH6, RHBG, RHCG, SLC12A3, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC2A11, SLC2A9, SLC30A2, SLC39A4, SLC39A5, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC7A7, SLC9A4, TRIP6, TRPC7	587	transmembrane transport
GO:0006810	1.897e-03	44.19	69 ANO10, AP1M2, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, CALCA, CLCNKA, CRYAA, CUBN, CYP27B1, FAM3D, FOLR1, FXYD2, FXYD3, HDAC6, ICMT, KCNE3, KCNH6, KCNJ1, KCNK5, MIF, NPHS2, PRLR, PRSS8, PSMD9, RAB25, RHBG, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SERPINB7, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC4A1, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, STRA6, TMED4, TRIP6, TRPC7, TSPO2, VDR	2226	transport
GO:0051234	2.609e-03	44.7	69 ANO10, AP1M2, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, CALCA, CLCNKA, CRYAA, CUBN, CYP27B1, FAM3D, FOLR1, FXYD2, FXYD3, HDAC6, ICMT, KCNE3, KCNH6, KCNJ1, KCNK5, MIF, NPHS2, PRLR, PRSS8, PSMD9, RAB25, RHBG, RHCG, SCIN, SCNN1A, SCNN1B, SCNN1G, SERPINB7, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC4A1, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, STRA6, TMED4, TRIP6, TRPC7, TSPO2, VDR	2252	establishment of localization
GO:0003097	3.607e-03	0.09925	3 AQP1, AQP2, AQP3	5	renal water transport
GO:0015793	3.607e-03	0.09925	3 AQP1, AQP2, AQP3	5	glycerol transport
GO:0006820	5.938e-03	1.528	8 FXYD3, SLC22A11, SLC22A12, SLC22A6, SLC22A8, SLC34A1, SLC34A3, SLC4A1	77	anion transport
GO:0015696	6.324e-03	0.1191	3 AQP1, RHBG, RHCG	6	ammonium transport
GO:0015791	6.324e-03	0.1191	3 AQP1, AQP2, AQP3	6	polyol transport
GO:0006885	1.190e-02	0.6154	5 ATP6V0A4, ATP6V1B1, CLN6, RHCG, SLC9A4	31	regulation of pH
GO:0071280	1.375e-02	0.0397	2 AQP1, AQP2	2	cellular response to copper ion
GO:0071288	1.375e-02	0.0397	2 AQP1, AQP2	2	cellular response to mercury ion
GO:0001977	1.399e-02	0.1588	3 AQP1, AQP2, AQP3	8	renal system process involved in regulation of blood volume
GO:0051179	1.548e-02	51.47	73 ANO10, AP1M2, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, CALCA, CLCNKA, CRYAA, CUBN, CYP27B1, FAM3D, FOLR1, FXYD2, FXYD3, HDAC6, HOXA7, ICMT, KCNE3, KCNH6, KCNJ1, KCNK5, LMX1B, MIF, NPHS2, PRLR, PRSS8, PSMD9, RAB25, RHBG, RHCG, S100A2, SCIN, SCNN1A, SCNN1B, SCNN1G, SERPINB7, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC4A1, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, STRA6, TDGF1, TMED4, TRIP6, TRPC7, TSPO2, VDR	2593	localization
GO:0015695	1.848e-02	0.397	4 AQP1, RHBG, RHCG, SLC22A13	20	organic cation transport
GO:0045616	1.908e-02	0.1787	3 AQP3, CYP27B1, HOXA7	9	regulation of keratinocyte differentiation
GO:0046689	1.908e-02	0.1787	3 AQP1, AQP2, SLC34A1	9	response to mercury ion
GO:0070633	1.908e-02	0.1787	3 AQP1, RHBG, RHCG	9	transepithelial transport
GO:0003073	2.294e-02	0.7345	5 AQP1, AQP2, AQP3, CALCA, REN	37	regulation of systemic arterial blood pressure
GO:0006684	2.444e-02	0.1985	3 ENPP7, SMPD1, SMPDL3B	10	sphingomyelin metabolic process
GO:0046903	2.666e-02	7.901	18 AQP1, AQP2, AQP3, ATP6V0A4, ATP6V1B1, CLCNKA, FAM3D, KCNJ1, KCNK5, MIF, NPHS2, PRLR, PSMD9, SCIN, SCNN1A, SCNN1B, SCNN1G, VDR	398	secretion
GO:0055067	2.724e-02	0.7742	5 ATP6V0A4, ATP6V1B1, CLN6, RHCG, SLC9A4	39	monovalent inorganic cation homeostasis
GO:0003071	3.018e-02	0.2184	3 AQP1, AQP2, AQP3	11	renal system process involved in regulation of systemic arterial blood pressure
GO:0051354	3.018e-02	0.2184	3 ARG2, CYP27B1, HDAC6	11	negative regulation of oxidoreductase activity
GO:0006685	3.076e-02	0.05955	2 SMPD1, SMPDL3B	3	sphingomyelin catabolic process
GO:0010979	3.076e-02	0.05955	2 CYP27B1, VDR	3	regulation of vitamin D 24-hydroxylase activity
GO:0010980	3.076e-02	0.05955	2 CYP27B1, VDR	3	positive regulation of vitamin D 24-hydroxylase activity
GO:0070634	3.076e-02	0.05955	2 RHBG, RHCG	3	transepithelial ammonium transport
GO:0015849	3.615e-02	2.68	9 FOLR1, MIF, SLC15A1, SLC19A1, SLC22A12, SLC22A6, SLC3A2, SLC6A19, SLC7A7	135	organic acid transport
GO:0030855	3.755e-02	2.7	9 AQP3, CYP27B1, ELF5, EVPL, HOXA7, PAX2, RHCG, TFCP2L1, UPK1B	136	epithelial cell differentiation
GO:0045604	4.407e-02	0.2581	3 AQP3, CYP27B1, HOXA7	13	regulation of epidermal cell differentiation
GO:0007565	4.824e-02	1.806	7 AQP2, CALCA, CYP27B1, PAPPA, PRLR, TFCP2L1, VDR	91	female pregnancy

Id	Pvalue	ExpCount	Count	Size	Term
GO:0016324	2.337e-14	2.668	24 AQP1, AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, CDHR2, CUBN, DPEP1, MUC1, MUC20, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC22A11, SLC22A12, SLC34A3, SLC39A4, SLC3A2, SLC5A12, SLC5A8, SLC9A4, UMOD	135	apical plasma membrane
GO:0045177	5.159e-14	3.36	26 AQP1, AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, CDHR2, CUBN, DPEP1, MUC1, MUC20, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC22A11, SLC22A12, SLC34A3, SLC39A4, SLC3A2, SLC4A9, SLC5A12, SLC5A8, SLC9A4, UMOD, USH1C	170	apical part of cell
GO:0031224	4.521e-10	73.46	123 ANO10, APCDD1L, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, B3GNT3, B4GALNT2, BSND, C12orf59, C1orf186, C2orf24, C9orf71, CA12, CASR, CDH16, CDHR2, CDHR5, CLCC1, CLCNKA, CLDN19, CLDN4, CLDN8, CLN6, CLRN3, CWH43, DPEP1, ENPP7, FAM151A, FCAMR, FMO1, FOLR1, FUT3, FUT6, FXYD2, FXYD3, GALNT14, GGT6, GPR114, HEPACAM2, HHLA2, ICMT, IL17RB, IL9R, ILDR1, INTS2, ITM2B, KCNE3, KCNH6, KCNJ1, KCNK5, KL, MTNR1A, MUC1, MUC13, NOX4, NPHS2, PDZK1IP1, PRLR, PRSS8, PTH1R, PTH2R, RDH8, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA3, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC44A4, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, SUSD2, TACSTD2, TDGF1, TM7SF3, TMC4, TMED4, TMEM115, TMEM150B, TMEM171, TMEM174, TMEM72, TMEM79, TMEM86A, TMPRSS4, TRIP6, TRPC7, TSPAN33, TSPO2, UMOD, UNC5CL, UPK1B, XPNPEP2	3717	intrinsic to membrane
GO:0016021	3.211e-09	71.9	119 ANO10, APCDD1L, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, B3GNT3, B4GALNT2, BSND, C12orf59, C1orf186, C2orf24, C9orf71, CA12, CASR, CDH16, CDHR2, CDHR5, CLCC1, CLCNKA, CLDN19, CLDN4, CLDN8, CLN6, CLRN3, CWH43, ENPP7, FAM151A, FCAMR, FMO1, FOLR1, FUT3, FUT6, FXYD2, FXYD3, GALNT14, GGT6, GPR114, HEPACAM2, HHLA2, ICMT, IL17RB, IL9R, ILDR1, INTS2, ITM2B, KCNE3, KCNH6, KCNJ1, KCNK5, KL, MTNR1A, MUC1, MUC13, NOX4, NPHS2, PDZK1IP1, PRLR, PRSS8, PTH1R, PTH2R, RDH8, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA3, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC44A4, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, SUSD2, TACSTD2, TM7SF3, TMC4, TMED4, TMEM115, TMEM150B, TMEM171, TMEM174, TMEM72, TMEM79, TMEM86A, TMPRSS4, TRIP6, TRPC7, TSPAN33, TSPO2, UNC5CL, UPK1B	3638	integral to membrane
GO:0044459	4.340e-09	31.46	69 AQP1, AQP2, AQP3, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, B3GNT3, BSND, CASR, CDHR2, CLCNKA, CLDN19, CLDN4, CLDN8, CUBN, DPEP1, EVPL, FOLR1, FXYD2, FXYD3, HDAC6, IL17RB, IL9R, KCNH6, KCNJ1, KCNK5, KL, MTNR1A, MUC1, MUC20, NOX4, NPHS2, PTH1R, PTH2R, RAB25, RDH8, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A9, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, TACSTD2, TDGF1, TRIP6, UMOD	1592	plasma membrane part
GO:0044425	6.506e-09	84.73	132 ANO10, AP1M2, APCDD1L, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, B3GNT3, B4GALNT2, BSND, C12orf59, C1orf186, C2orf24, C9orf71, CA12, CASR, CDH16, CDHR2, CDHR5, CLCC1, CLCNKA, CLDN19, CLDN4, CLDN8, CLN6, CLRN3, CUBN, CWH43, DPEP1, ENPP7, EVPL, FAM151A, FCAMR, FMO1, FOLR1, FUT3, FUT6, FXYD2, FXYD3, GALNT14, GGT6, GPR114, HDAC6, HEPACAM2, HHLA2, ICMT, IL17RB, IL9R, ILDR1, INTS2, ITM2B, KCNE3, KCNH6, KCNJ1, KCNK5, KL, MTNR1A, MUC1, MUC13, MUC20, NOX4, NPHS2, PDZK1IP1, PRLR, PRSS8, PTH1R, PTH2R, PTPN1, RAB25, RDH8, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SHISA3, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC44A4, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, SUSD2, TACSTD2, TDGF1, TM7SF3, TMC4, TMED4, TMEM115, TMEM150B, TMEM171, TMEM174, TMEM72, TMEM79, TMEM86A, TMPRSS4, TRIP6, TRPC7, TSPAN33, TSPO2, UMOD, UNC5CL, UPK1B, XPNPEP2	4287	membrane part
GO:0016323	3.588e-07	3.795	19 AQP1, AQP2, AQP3, ATP6V1B1, BSND, CLDN19, MUC20, NOX4, RHBG, RHCG, SLC22A6, SLC22A8, SLC39A5, SLC4A1, SLC4A9, SLC7A7, SLC9A4, ST14, TRIP6	192	basolateral plasma membrane
GO:0016020	4.120e-07	101.7	144 ACPP, ANO10, AP1M2, APCDD1L, APEX2, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, B3GNT3, B4GALNT2, BSND, C12orf59, C1orf186, C2orf24, C9orf71, CA12, CASR, CDH16, CDHR2, CDHR5, CLCC1, CLCNKA, CLDN19, CLDN4, CLDN8, CLN6, CLRN3, COQ4, CUBN, CWH43, CYP27B1, DPEP1, ENPP7, EVPL, FAM151A, FCAMR, FMO1, FOLR1, FUT3, FUT6, FXYD2, FXYD3, GALNT14, GGT6, GPR114, HDAC6, HEPACAM2, HHLA2, ICMT, IL17RB, IL9R, ILDR1, INTS2, ITM2B, KCNE3, KCNH6, KCNJ1, KCNK5, KL, MTNR1A, MUC1, MUC13, MUC20, NOX4, NPHS2, PAPPA, PAPPA2, PDZK1IP1, PLA2G4F, PRLR, PRSS8, PRX, PTH1R, PTH2R, PTPN1, RAB25, RDH8, REN, RHBG, RHCG, RNPEP, SCNN1A, SCNN1B, SCNN1G, SHISA3, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC44A4, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, SUCLG1, SUSD2, TACSTD2, TDGF1, TFCP2L1, TM7SF3, TMC4, TMED4, TMEM115, TMEM150B, TMEM171, TMEM174, TMEM72, TMEM79, TMEM86A, TMPRSS4, TRIP6, TRPC7, TSPAN33, TSPO2, UMOD, UNC5CL, UPK1B, XPNPEP2	5148	membrane
GO:0005887	2.190e-05	18.26	41 AQP1, ATP12A, B3GNT3, BSND, CASR, CLCNKA, CLDN4, FOLR1, FXYD2, FXYD3, IL17RB, IL9R, KCNH6, KCNJ1, KCNK5, KL, MTNR1A, MUC1, NPHS2, PTH1R, PTH2R, RDH8, RHBG, RHCG, SCNN1G, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A9, SLC34A1, SLC4A1, SLC6A19, SLC7A7, ST14, TACSTD2, TRIP6	924	integral to plasma membrane
GO:0031226	3.577e-05	18.66	41 AQP1, ATP12A, B3GNT3, BSND, CASR, CLCNKA, CLDN4, FOLR1, FXYD2, FXYD3, IL17RB, IL9R, KCNH6, KCNJ1, KCNK5, KL, MTNR1A, MUC1, NPHS2, PTH1R, PTH2R, RDH8, RHBG, RHCG, SCNN1G, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A9, SLC34A1, SLC4A1, SLC6A19, SLC7A7, ST14, TACSTD2, TRIP6	944	intrinsic to plasma membrane
GO:0005886	4.852e-05	51.86	83 AQP1, AQP2, AQP3, ATP12A, ATP6V0A4, ATP6V0D2, ATP6V1B1, B3GNT3, BSND, CASR, CDH16, CDHR2, CDHR5, CLCNKA, CLDN19, CLDN4, CLDN8, CUBN, DPEP1, EVPL, FCAMR, FOLR1, FXYD2, FXYD3, GPR114, HDAC6, IL17RB, IL9R, ILDR1, ITM2B, KCNH6, KCNJ1, KCNK5, KL, MTNR1A, MUC1, MUC13, MUC20, NOX4, NPHS2, PRSS8, PRX, PTH1R, PTH2R, RAB25, RDH8, RHBG, RHCG, RNPEP, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A9, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A8, SLC6A19, SLC7A7, SLC9A4, ST14, STRA6, TACSTD2, TDGF1, TM7SF3, TRIP6, UMOD, XPNPEP2	2624	plasma membrane
GO:0031526	1.466e-04	0.4743	6 AQP1, ATP6V0A4, CUBN, SLC22A12, SLC34A1, SLC34A3	24	brush border membrane
GO:0005903	1.302e-03	0.7115	6 AQP1, ATP6V0A4, CUBN, SLC22A12, SLC34A1, SLC34A3	36	brush border
GO:0031253	1.460e-03	1.799	9 AQP1, ATP6V0A4, CUBN, DPEP1, MUC20, RAB25, SLC22A12, SLC34A1, SLC34A3	91	cell projection membrane
GO:0016471	4.132e-03	0.1383	3 ATP6V0A4, ATP6V0D2, ATP6V1B1	7	vacuolar proton-transporting V-type ATPase complex
GO:0005773	7.044e-03	4.388	13 ACPP, AQP1, AQP2, ATP6V0A4, ATP6V0D2, ATP6V1B1, CUBN, HEXA, PLA2G15, PLA2G4F, PRCP, SLC30A2, SMPD1	222	vacuole
GO:0005774	1.237e-02	2.016	8 ACPP, AQP1, ATP6V0A4, ATP6V0D2, ATP6V1B1, CUBN, PLA2G4F, SLC30A2	102	vacuolar membrane
GO:0044437	1.689e-02	2.134	8 ACPP, AQP1, ATP6V0A4, ATP6V0D2, ATP6V1B1, CUBN, PLA2G4F, SLC30A2	108	vacuolar part
GO:0034706	2.713e-02	0.2767	3 SCNN1A, SCNN1B, SCNN1G	14	sodium channel complex
GO:0033176	3.210e-02	0.2965	3 ATP6V0A4, ATP6V0D2, ATP6V1B1	15	proton-transporting V-type ATPase complex

Id	Pvalue	ExpCount	Count	Size	Term
GO:0022857	2.366e-13	13.6	50 ANO10, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCC1, CLCNKA, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, TRPC7	712	transmembrane transporter activity
GO:0022891	2.413e-12	12.39	46 ANO10, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCC1, CLCNKA, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC15A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC4A1, SLC4A9, SLC5A2, SLC6A19, SLC7A7, SLC9A4, TRPC7	649	substrate-specific transmembrane transporter activity
GO:0015075	3.000e-11	10.79	41 ANO10, AQP1, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCC1, CLCNKA, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC15A1, SLC22A11, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC4A1, SLC4A9, SLC5A2, SLC6A19, SLC9A4, TRPC7	565	ion transmembrane transporter activity
GO:0005215	3.202e-11	17.42	53 ANO10, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCC1, CLCNKA, CUBN, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, RBP2, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC47A2, SLC4A1, SLC4A9, SLC5A10, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4, TRPC7	912	transporter activity
GO:0022892	2.725e-10	14.4	46 ANO10, AQP1, AQP2, AQP3, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, BSND, CLCC1, CLCNKA, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC15A1, SLC22A11, SLC22A12, SLC22A13, SLC22A6, SLC22A8, SLC28A2, SLC2A11, SLC2A9, SLC30A2, SLC34A1, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC4A1, SLC4A9, SLC5A2, SLC6A19, SLC7A7, SLC9A4, TRPC7	754	substrate-specific transporter activity
GO:0022804	1.472e-08	5.29	25 ATP12A, ATP4B, ATP6V0A4, ATP6V1B1, FXYD2, SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A6, SLC22A8, SLC28A2, SLC2A9, SLC34A1, SLC34A3, SLC3A2, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC7A7, SLC9A4	277	active transmembrane transporter activity
GO:0015291	2.780e-08	3.056	19 SLC12A3, SLC15A1, SLC19A1, SLC22A11, SLC22A6, SLC22A8, SLC28A2, SLC2A9, SLC34A1, SLC34A3, SLC3A2, SLC47A2, SLC4A1, SLC4A9, SLC5A12, SLC5A2, SLC5A8, SLC6A19, SLC9A4	160	secondary active transmembrane transporter activity
GO:0008324	1.192e-07	8.345	30 AQP1, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, FXYD2, KCNE3, KCNH6, KCNJ1, KCNK5, RHBG, RHCG, SCNN1A, SCNN1B, SCNN1G, SLC12A3, SLC15A1, SLC22A13, SLC28A2, SLC2A9, SLC30A2, SLC34A3, SLC39A4, SLC39A5, SLC3A2, SLC5A2, SLC6A19, SLC9A4, TRPC7	437	cation transmembrane transporter activity
GO:0008509	2.817e-05	2.253	13 ANO10, BSND, CLCC1, CLCNKA, FXYD3, SLC12A3, SLC22A11, SLC22A6, SLC22A8, SLC34A1, SLC34A3, SLC4A1, SLC4A9	118	anion transmembrane transporter activity
GO:0022890	4.205e-05	3.151	15 AQP1, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, FXYD2, RHBG, RHCG, SLC28A2, SLC34A3, SLC39A4, SLC5A2, SLC6A19, SLC9A4	165	inorganic cation transmembrane transporter activity
GO:0005452	1.116e-04	0.2292	5 SLC22A11, SLC22A6, SLC22A8, SLC4A1, SLC4A9	12	inorganic anion exchanger activity
GO:0015077	2.833e-04	2.406	12 AQP1, ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, FXYD2, SLC28A2, SLC34A3, SLC5A2, SLC6A19, SLC9A4	126	monovalent inorganic cation transmembrane transporter activity
GO:0015297	4.043e-04	1.031	8 SLC22A11, SLC22A6, SLC22A8, SLC3A2, SLC47A2, SLC4A1, SLC4A9, SLC9A4	54	antiporter activity
GO:0016805	4.483e-04	0.1528	4 CNDP2, DPEP1, PEPD, SCRN2	8	dipeptidase activity
GO:0015380	4.655e-04	0.3056	5 SLC22A11, SLC22A6, SLC22A8, SLC4A1, SLC4A9	16	anion exchanger activity
GO:0015301	6.221e-04	0.3247	5 SLC22A11, SLC22A6, SLC22A8, SLC4A1, SLC4A9	17	anion:anion antiporter activity
GO:0015300	6.379e-04	0.8021	7 SLC22A11, SLC22A6, SLC22A8, SLC3A2, SLC4A1, SLC4A9, SLC9A4	42	solute:solute antiporter activity
GO:0015168	1.226e-03	0.07639	3 AQP1, AQP2, AQP3	4	glycerol transmembrane transporter activity
GO:0015293	1.587e-03	2.043	10 SLC12A3, SLC15A1, SLC28A2, SLC2A9, SLC34A1, SLC34A3, SLC5A12, SLC5A2, SLC5A8, SLC6A19	107	symporter activity
GO:0022803	1.948e-03	6.168	18 ANO10, AQP1, AQP2, AQP3, BSND, CLCC1, CLCNKA, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G, SLC5A8, TRPC7	323	passive transmembrane transporter activity
GO:0046873	2.525e-03	2.177	10 AQP1, ATP12A, ATP4B, FXYD2, SLC28A2, SLC34A3, SLC39A4, SLC39A5, SLC5A2, SLC6A19	114	metal ion transmembrane transporter activity
GO:0004767	2.656e-03	0.09549	3 ENPP7, SMPD1, SMPDL3B	5	sphingomyelin phosphodiesterase activity
GO:0015166	2.656e-03	0.09549	3 AQP1, AQP2, AQP3	5	polyol transmembrane transporter activity
GO:0015665	2.656e-03	0.09549	3 AQP1, AQP2, AQP3	5	alcohol transmembrane transporter activity
GO:0022838	3.578e-03	5.939	17 ANO10, AQP1, AQP2, AQP3, BSND, CLCC1, CLCNKA, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G, TRPC7	311	substrate-specific channel activity
GO:0051739	4.674e-03	0.1146	3 AQP1, RHBG, RHCG	6	ammonia transmembrane transporter activity
GO:0015267	5.071e-03	6.149	17 ANO10, AQP1, AQP2, AQP3, BSND, CLCC1, CLCNKA, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G, TRPC7	322	channel activity
GO:0015079	5.196e-03	0.2865	4 AQP1, ATP12A, ATP4B, FXYD2	15	potassium ion transmembrane transporter activity
GO:0015280	7.281e-03	0.1337	3 SCNN1A, SCNN1B, SCNN1G	7	amiloride-sensitive sodium channel activity
GO:0030506	7.281e-03	0.1337	3 RHBG, RHCG, SLC4A1	7	ankyrin binding
GO:0008238	9.179e-03	1.299	7 CNDP2, DPEP1, PEPD, PRCP, RNPEP, SCRN2, XPNPEP2	68	exopeptidase activity
GO:0004991	1.067e-02	0.03819	2 PTH1R, PTH2R	2	parathyroid hormone receptor activity
GO:0017060	1.067e-02	0.03819	2 FUT3, FUT6	2	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
GO:0015294	1.315e-02	1.394	7 SLC12A3, SLC15A1, SLC28A2, SLC2A9, SLC34A3, SLC5A2, SLC6A19	73	solute:cation symporter activity
GO:0005216	1.710e-02	5.748	15 ANO10, AQP1, BSND, CLCC1, CLCNKA, FXYD2, FXYD3, KCNE3, KCNH6, KCNJ1, KCNK5, SCNN1A, SCNN1B, SCNN1G, TRPC7	301	ion channel activity
GO:0015078	1.982e-02	1.108	6 ATP12A, ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, SLC9A4	58	hydrogen ion transmembrane transporter activity
GO:0008514	2.388e-02	0.2101	3 SLC22A11, SLC22A6, SLC22A8	11	organic anion transmembrane transporter activity
GO:0008556	2.388e-02	0.2101	3 ATP12A, ATP4B, FXYD2	11	potassium-transporting ATPase activity
GO:0015250	2.388e-02	0.2101	3 AQP1, AQP2, AQP3	11	water channel activity
GO:0008519	2.485e-02	0.05729	2 RHBG, RHCG	3	ammonium transmembrane transporter activity
GO:0008900	2.485e-02	0.05729	2 ATP12A, ATP4B	3	hydrogen:potassium-exchanging ATPase activity
GO:0005372	2.902e-02	0.2292	3 AQP1, AQP2, AQP3	12	water transmembrane transporter activity
GO:0015101	2.902e-02	0.2292	3 RHBG, RHCG, SLC22A13	12	organic cation transmembrane transporter activity
GO:0015081	3.290e-02	1.26	6 ATP4B, FXYD2, SLC28A2, SLC34A3, SLC5A2, SLC6A19	66	sodium ion transmembrane transporter activity
GO:0004620	4.151e-02	1.337	6 CASR, ENPP7, PLA2G15, PLA2G4F, SMPD1, SMPDL3B	70	phospholipase activity

Id	Pvalue	ExpCount	Count	Size	Term
04966	7.076e-04	0.3504	5 ATP4B, ATP6V0A4, ATP6V0D2, ATP6V1B1, SLC4A1	21	Collecting duct acid secretion
04960	5.062e-03	0.5506	5 FXYD2, KCNJ1, SCNN1A, SCNN1B, SCNN1G	33	Aldosterone-regulated sodium reabsorption

No enriched terms

No enriched terms

Entrez genes

ACAD10acyl-CoA dehydrogenase family, member 10 (ENSG00000111271), score: 0.46 ACOT11acyl-CoA thioesterase 11 (ENSG00000162390), score: 0.49 ACPPacid phosphatase, prostate (ENSG00000014257), score: 0.58 ALDH3B1aldehyde dehydrogenase 3 family, member B1 (ENSG00000006534), score: 0.58 ANO10anoctamin 10 (ENSG00000160746), score: 0.49 AP1M2adaptor-related protein complex 1, mu 2 subunit (ENSG00000129354), score: 0.5 APCDD1Ladenomatosis polyposis coli down-regulated 1-like (ENSG00000198768), score: 0.6 APEHN-acylaminoacyl-peptide hydrolase (ENSG00000164062), score: 0.46 APEX2APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (ENSG00000169188), score: 0.55 AQP2aquaporin 2 (collecting duct) (ENSG00000167580), score: 0.58 AQP3aquaporin 3 (Gill blood group) (ENSG00000165272), score: 0.5 ARG2arginase, type II (ENSG00000081181), score: 0.48 ARSEarylsulfatase E (chondrodysplasia punctata 1) (ENSG00000157399), score: 0.48 ATP12AATPase, H+/K+ transporting, nongastric, alpha polypeptide (ENSG00000075673), score: 0.71 ATP4BATPase, H+/K+ exchanging, beta polypeptide (ENSG00000186009), score: 0.47 ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4 (ENSG00000105929), score: 0.48 ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 (ENSG00000147614), score: 0.46 ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 (ENSG00000116039), score: 0.51 B3GNT3UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 (ENSG00000179913), score: 0.87 B4GALNT2beta-1,4-N-acetyl-galactosaminyl transferase 2 (ENSG00000167080), score: 0.57 BARX2BARX homeobox 2 (ENSG00000043039), score: 0.46 BSNDBartter syndrome, infantile, with sensorineural deafness (Barttin) (ENSG00000162399), score: 0.47 C12orf59chromosome 12 open reading frame 59 (ENSG00000165685), score: 0.48 C14orf45chromosome 14 open reading frame 45 (ENSG00000119636), score: 0.47 C19orf21chromosome 19 open reading frame 21 (ENSG00000099812), score: 0.5 C19orf33chromosome 19 open reading frame 33 (ENSG00000167644), score: 0.46 C1orf106chromosome 1 open reading frame 106 (ENSG00000163362), score: 0.48 C1orf186chromosome 1 open reading frame 186 (ENSG00000196533), score: 1 C1orf52chromosome 1 open reading frame 52 (ENSG00000162642), score: -0.47 C22orf28chromosome 22 open reading frame 28 (ENSG00000100220), score: 0.48 C2orf24chromosome 2 open reading frame 24 (ENSG00000115649), score: 0.49 C2orf49chromosome 2 open reading frame 49 (ENSG00000135974), score: -0.49 C2orf54chromosome 2 open reading frame 54 (ENSG00000172478), score: 0.52 C5orf32chromosome 5 open reading frame 32 (ENSG00000120306), score: 0.48 C9orf71chromosome 9 open reading frame 71 (ENSG00000181778), score: 0.47 CA12carbonic anhydrase XII (ENSG00000074410), score: 0.5 CALCAcalcitonin-related polypeptide alpha (ENSG00000110680), score: 0.54 CASRcalcium-sensing receptor (ENSG00000036828), score: 0.47 CCNT2cyclin T2 (ENSG00000082258), score: -0.56 CDH16cadherin 16, KSP-cadherin (ENSG00000166589), score: 0.53 CDHR2cadherin-related family member 2 (ENSG00000074276), score: 0.56 CDHR5cadherin-related family member 5 (ENSG00000099834), score: 0.49 CHORDC1cysteine and histidine-rich domain (CHORD)-containing 1 (ENSG00000110172), score: -0.54 CHP2calcineurin B homologous protein 2 (ENSG00000166869), score: 0.65 CIRH1Acirrhosis, autosomal recessive 1A (cirhin) (ENSG00000141076), score: 0.47 CLCC1chloride channel CLIC-like 1 (ENSG00000121940), score: -0.48 CLCNKAchloride channel Ka (ENSG00000186510), score: 0.5 CLDN19claudin 19 (ENSG00000164007), score: 0.57 CLDN4claudin 4 (ENSG00000189143), score: 0.46 CLDN8claudin 8 (ENSG00000156284), score: 0.48 CLN6ceroid-lipofuscinosis, neuronal 6, late infantile, variant (ENSG00000128973), score: 0.48 CLRN3clarin 3 (ENSG00000180745), score: 0.47 CNDP2CNDP dipeptidase 2 (metallopeptidase M20 family) (ENSG00000133313), score: 0.48 COQ4coenzyme Q4 homolog (S. cerevisiae) (ENSG00000167113), score: 0.51 CRYAAcrystallin, alpha A (ENSG00000160202), score: 0.51 CRYBB3crystallin, beta B3 (ENSG00000100053), score: 0.56 CTRCchymotrypsin C (caldecrin) (ENSG00000162438), score: 0.56 CUBNcubilin (intrinsic factor-cobalamin receptor) (ENSG00000107611), score: 0.5 CWH43cell wall biogenesis 43 C-terminal homolog (S. cerevisiae) (ENSG00000109182), score: 0.55 CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 1 (ENSG00000111012), score: 0.65 DEPDC6DEP domain containing 6 (ENSG00000155792), score: 0.46 DLEC1deleted in lung and esophageal cancer 1 (ENSG00000008226), score: 0.48 DNAJC11DnaJ (Hsp40) homolog, subfamily C, member 11 (ENSG00000007923), score: 0.53 DPEP1dipeptidase 1 (renal) (ENSG00000015413), score: 0.46 DUSP23dual specificity phosphatase 23 (ENSG00000158716), score: 0.48 EEF1Geukaryotic translation elongation factor 1 gamma (ENSG00000149016), score: 0.5 EIF3Keukaryotic translation initiation factor 3, subunit K (ENSG00000178982), score: 0.5 ELF5E74-like factor 5 (ets domain transcription factor) (ENSG00000135374), score: 0.45 ENAMenamelin (ENSG00000132464), score: 0.45 ENPP7ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENSG00000182156), score: 0.55 ERP27endoplasmic reticulum protein 27 (ENSG00000139055), score: 0.73 EVPLenvoplakin (ENSG00000167880), score: 0.49 FAM150Bfamily with sequence similarity 150, member B (ENSG00000189292), score: 0.51 FAM151Afamily with sequence similarity 151, member A (ENSG00000162391), score: 0.57 FAM3Dfamily with sequence similarity 3, member D (ENSG00000198643), score: 0.49 FBN3fibrillin 3 (ENSG00000142449), score: 0.47 FBXO17F-box protein 17 (ENSG00000104835), score: 0.45 FCAMRFc receptor, IgA, IgM, high affinity (ENSG00000162897), score: 0.54 FMO1flavin containing monooxygenase 1 (ENSG00000010932), score: 0.47 FOLR1folate receptor 1 (adult) (ENSG00000110195), score: 0.58 FOXI1forkhead box I1 (ENSG00000168269), score: 0.46 FUT3fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) (ENSG00000171124), score: 0.72 FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase) (ENSG00000156413), score: 0.5 FXYD2FXYD domain containing ion transport regulator 2 (ENSG00000137731), score: 0.47 FXYD3FXYD domain containing ion transport regulator 3 (ENSG00000089356), score: 0.45 GALNT14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14) (ENSG00000158089), score: 0.47 GCM1glial cells missing homolog 1 (Drosophila) (ENSG00000137270), score: 0.47 GGT6gamma-glutamyltransferase 6 (ENSG00000167741), score: 0.73 GHDCGH3 domain containing (ENSG00000167925), score: 0.49 GLIS2GLIS family zinc finger 2 (ENSG00000126603), score: 0.48 GNPDA1glucosamine-6-phosphate deaminase 1 (ENSG00000113552), score: 0.54 GPR114G protein-coupled receptor 114 (ENSG00000159618), score: 0.82 HDAC6histone deacetylase 6 (ENSG00000094631), score: 0.46 HEPACAM2HEPACAM family member 2 (ENSG00000188175), score: 0.5 HEXAhexosaminidase A (alpha polypeptide) (ENSG00000213614), score: 0.52 HHLA2HERV-H LTR-associating 2 (ENSG00000114455), score: 0.67 HOXA11homeobox A11 (ENSG00000005073), score: 0.47 HOXA7homeobox A7 (ENSG00000122592), score: 0.47 HOXC10homeobox C10 (ENSG00000180818), score: 0.53 HOXC5homeobox C5 (ENSG00000172789), score: 0.46 HOXD10homeobox D10 (ENSG00000128710), score: 0.46 ICMTisoprenylcysteine carboxyl methyltransferase (ENSG00000116237), score: 0.5 IL17RBinterleukin 17 receptor B (ENSG00000056736), score: 0.58 IL9Rinterleukin 9 receptor (ENSG00000124334), score: 0.56 ILDR1immunoglobulin-like domain containing receptor 1 (ENSG00000145103), score: 0.51 INMTindolethylamine N-methyltransferase (ENSG00000106125), score: 0.63 INTS2integrator complex subunit 2 (ENSG00000108506), score: -0.5 ITM2Bintegral membrane protein 2B (ENSG00000136156), score: 0.49 KCNE3potassium voltage-gated channel, Isk-related family, member 3 (ENSG00000175538), score: 0.67 KCNH6potassium voltage-gated channel, subfamily H (eag-related), member 6 (ENSG00000173826), score: 0.82 KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1 (ENSG00000151704), score: 0.48 KCNK5potassium channel, subfamily K, member 5 (ENSG00000164626), score: 0.48 KIAA0100KIAA0100 (ENSG00000007202), score: 0.52 KIAA1191KIAA1191 (ENSG00000122203), score: 0.52 KLklotho (ENSG00000133116), score: 0.47 KRT7keratin 7 (ENSG00000135480), score: 0.47 LGALS2lectin, galactoside-binding, soluble, 2 (ENSG00000100079), score: 0.5 LMX1BLIM homeobox transcription factor 1, beta (ENSG00000136944), score: 0.49 LYG1lysozyme G-like 1 (ENSG00000144214), score: 0.62 MCATmalonyl CoA:ACP acyltransferase (mitochondrial) (ENSG00000100294), score: 0.52 MCCD1mitochondrial coiled-coil domain 1 (ENSG00000204511), score: 0.69 MED30mediator complex subunit 30 (ENSG00000164758), score: -0.47 METTL1methyltransferase like 1 (ENSG00000037897), score: 0.5 MIFmacrophage migration inhibitory factor (glycosylation-inhibiting factor) (ENSG00000133460), score: 0.45 MIOXmyo-inositol oxygenase (ENSG00000100253), score: 0.49 MTNR1Amelatonin receptor 1A (ENSG00000168412), score: 0.5 MUC1mucin 1, cell surface associated (ENSG00000185499), score: 0.48 MUC13mucin 13, cell surface associated (ENSG00000173702), score: 0.7 MUC20mucin 20, cell surface associated (ENSG00000176945), score: 0.52 NCCRP1non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) (ENSG00000188505), score: 0.76 NOX4NADPH oxidase 4 (ENSG00000086991), score: 0.55 NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin) (ENSG00000116218), score: 0.48 OGG18-oxoguanine DNA glycosylase (ENSG00000114026), score: 0.46 OLFM4olfactomedin 4 (ENSG00000102837), score: 0.49 PABPC1Lpoly(A) binding protein, cytoplasmic 1-like (ENSG00000101104), score: 0.5 PAK4p21 protein (Cdc42/Rac)-activated kinase 4 (ENSG00000130669), score: 0.46 PAPPApregnancy-associated plasma protein A, pappalysin 1 (ENSG00000182752), score: 0.48 PAPPA2pappalysin 2 (ENSG00000116183), score: 0.67 PAX2paired box 2 (ENSG00000075891), score: 0.53 PAX8paired box 8 (ENSG00000125618), score: 0.49 PDZK1IP1PDZK1 interacting protein 1 (ENSG00000162366), score: 0.53 PEPDpeptidase D (ENSG00000124299), score: 0.53 PLA2G15phospholipase A2, group XV (ENSG00000103066), score: 0.45 PLA2G4Fphospholipase A2, group IVF (ENSG00000168907), score: 0.51 PLEKHJ1pleckstrin homology domain containing, family J member 1 (ENSG00000104886), score: 0.51 PRCPprolylcarboxypeptidase (angiotensinase C) (ENSG00000137509), score: 0.48 PRDM14PR domain containing 14 (ENSG00000147596), score: 0.49 PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit (ENSG00000111725), score: 0.53 PRLRprolactin receptor (ENSG00000113494), score: 0.53 PRR13proline rich 13 (ENSG00000205352), score: 0.5 PRR15proline rich 15 (ENSG00000176532), score: 0.5 PRR15Lproline rich 15-like (ENSG00000167183), score: 0.46 PRSS8protease, serine, 8 (ENSG00000052344), score: 0.52 PRXperiaxin (ENSG00000105227), score: 0.55 PSMD9proteasome (prosome, macropain) 26S subunit, non-ATPase, 9 (ENSG00000110801), score: 0.49 PTH1Rparathyroid hormone 1 receptor (ENSG00000160801), score: 0.53 PTH2Rparathyroid hormone 2 receptor (ENSG00000144407), score: 0.58 PTPN1protein tyrosine phosphatase, non-receptor type 1 (ENSG00000196396), score: 0.5 RAB25RAB25, member RAS oncogene family (ENSG00000132698), score: 0.48 RASSF10Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 (ENSG00000189431), score: 0.46 RASSF6Ras association (RalGDS/AF-6) domain family member 6 (ENSG00000169435), score: 0.47 RBP2retinol binding protein 2, cellular (ENSG00000114113), score: 0.82 RDH12retinol dehydrogenase 12 (all-trans/9-cis/11-cis) (ENSG00000139988), score: 0.48 RDH8retinol dehydrogenase 8 (all-trans) (ENSG00000080511), score: 0.57 REG3Aregenerating islet-derived 3 alpha (ENSG00000172016), score: 0.54 RENrenin (ENSG00000143839), score: 0.57 RENBPrenin binding protein (ENSG00000102032), score: 0.5 RHBGRh family, B glycoprotein (gene/pseudogene) (ENSG00000132677), score: 0.47 RHCGRh family, C glycoprotein (ENSG00000140519), score: 0.49 RNPEParginyl aminopeptidase (aminopeptidase B) (ENSG00000176393), score: 0.47 S100A2S100 calcium binding protein A2 (ENSG00000196754), score: 0.6 SCINscinderin (ENSG00000006747), score: 0.46 SCNN1Asodium channel, nonvoltage-gated 1 alpha (ENSG00000111319), score: 0.48 SCNN1Bsodium channel, nonvoltage-gated 1, beta (ENSG00000168447), score: 0.54 SCNN1Gsodium channel, nonvoltage-gated 1, gamma (ENSG00000166828), score: 0.48 SCRN2secernin 2 (ENSG00000141295), score: 0.48 SERPINB7serpin peptidase inhibitor, clade B (ovalbumin), member 7 (ENSG00000166396), score: 0.46 SHISA3shisa homolog 3 (Xenopus laevis) (ENSG00000178343), score: 0.56 SLC12A3solute carrier family 12 (sodium/chloride transporters), member 3 (ENSG00000070915), score: 0.52 SLC15A1solute carrier family 15 (oligopeptide transporter), member 1 (ENSG00000088386), score: 0.54 SLC19A1solute carrier family 19 (folate transporter), member 1 (ENSG00000173638), score: 0.49 SLC22A11solute carrier family 22 (organic anion/urate transporter), member 11 (ENSG00000168065), score: 0.49 SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12 (ENSG00000197891), score: 0.5 SLC22A13solute carrier family 22 (organic anion transporter), member 13 (ENSG00000172940), score: 0.7 SLC22A6solute carrier family 22 (organic anion transporter), member 6 (ENSG00000197901), score: 0.48 SLC22A8solute carrier family 22 (organic anion transporter), member 8 (ENSG00000149452), score: 0.55 SLC28A2solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 (ENSG00000137860), score: 0.48 SLC2A9solute carrier family 2 (facilitated glucose transporter), member 9 (ENSG00000109667), score: 0.47 SLC30A2solute carrier family 30 (zinc transporter), member 2 (ENSG00000158014), score: 0.58 SLC34A1solute carrier family 34 (sodium phosphate), member 1 (ENSG00000131183), score: 0.49 SLC34A3solute carrier family 34 (sodium phosphate), member 3 (ENSG00000198569), score: 0.49 SLC39A4solute carrier family 39 (zinc transporter), member 4 (ENSG00000147804), score: 0.57 SLC39A5solute carrier family 39 (metal ion transporter), member 5 (ENSG00000139540), score: 0.58 SLC3A2solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (ENSG00000168003), score: 0.46 SLC44A4solute carrier family 44, member 4 (ENSG00000204385), score: 0.54 SLC47A2solute carrier family 47, member 2 (ENSG00000180638), score: 0.46 SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) (ENSG00000004939), score: 0.52 SLC4A9solute carrier family 4, sodium bicarbonate cotransporter, member 9 (ENSG00000113073), score: 0.46 SLC5A10solute carrier family 5 (sodium/glucose cotransporter), member 10 (ENSG00000154025), score: 0.57 SLC5A12solute carrier family 5 (sodium/glucose cotransporter), member 12 (ENSG00000148942), score: 0.52 SLC5A2solute carrier family 5 (sodium/glucose cotransporter), member 2 (ENSG00000140675), score: 0.52 SLC5A8solute carrier family 5 (iodide transporter), member 8 (ENSG00000139357), score: 0.57 SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19 (ENSG00000174358), score: 0.57 SLC7A7solute carrier family 7 (cationic amino acid transporter, y+ system), member 7 (ENSG00000155465), score: 0.5 SLC9A4solute carrier family 9 (sodium/hydrogen exchanger), member 4 (ENSG00000180251), score: 0.57 SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal (ENSG00000166311), score: 0.5 SMPDL3Bsphingomyelin phosphodiesterase, acid-like 3B (ENSG00000130768), score: 0.64 SOSTsclerostin (ENSG00000167941), score: 0.57 ST14suppression of tumorigenicity 14 (colon carcinoma) (ENSG00000149418), score: 0.49 STRA6stimulated by retinoic acid gene 6 homolog (mouse) (ENSG00000137868), score: 0.47 SUCLG1succinate-CoA ligase, alpha subunit (ENSG00000163541), score: 0.5 SUSD2sushi domain containing 2 (ENSG00000099994), score: 0.66 TACSTD2tumor-associated calcium signal transducer 2 (ENSG00000184292), score: 0.58 TDGF1teratocarcinoma-derived growth factor 1 (ENSG00000241186), score: 0.47 TFCP2L1transcription factor CP2-like 1 (ENSG00000115112), score: 0.52 TH1LTH1-like (Drosophila) (ENSG00000101158), score: 0.46 TM7SF3transmembrane 7 superfamily member 3 (ENSG00000064115), score: 0.5 TMC4transmembrane channel-like 4 (ENSG00000167608), score: 0.58 TMED4transmembrane emp24 protein transport domain containing 4 (ENSG00000158604), score: 0.61 TMEM115transmembrane protein 115 (ENSG00000126062), score: 0.46 TMEM150Btransmembrane protein 150B (ENSG00000180061), score: 0.67 TMEM171transmembrane protein 171 (ENSG00000157111), score: 0.52 TMEM174transmembrane protein 174 (ENSG00000164325), score: 0.51 TMEM72transmembrane protein 72 (ENSG00000187783), score: 0.53 TMEM79transmembrane protein 79 (ENSG00000163472), score: 0.63 TMEM86Atransmembrane protein 86A (ENSG00000151117), score: 0.48 TMPRSS4transmembrane protease, serine 4 (ENSG00000137648), score: 0.63 TRIM10tripartite motif-containing 10 (ENSG00000204613), score: 0.8 TRIM15tripartite motif-containing 15 (ENSG00000204610), score: 0.82 TRIM6-TRIM34TRIM6-TRIM34 readthrough (ENSG00000242885), score: 0.47 TRIP6thyroid hormone receptor interactor 6 (ENSG00000087077), score: 0.5 TRPC7transient receptor potential cation channel, subfamily C, member 7 (ENSG00000069018), score: 0.86 TSPAN33tetraspanin 33 (ENSG00000158457), score: 0.52 TSPO2translocator protein 2 (ENSG00000112212), score: 0.58 TTC22tetratricopeptide repeat domain 22 (ENSG00000006555), score: 0.55 TUBAL3tubulin, alpha-like 3 (ENSG00000178462), score: 0.83 UMODuromodulin (ENSG00000169344), score: 0.47 UNC5CLunc-5 homolog C (C. elegans)-like (ENSG00000124602), score: 0.51 UPK1Buroplakin 1B (ENSG00000114638), score: 0.46 USH1CUsher syndrome 1C (autosomal recessive, severe) (ENSG00000006611), score: 0.49 VDRvitamin D (1,25- dihydroxyvitamin D3) receptor (ENSG00000111424), score: 0.47 VGLL1vestigial like 1 (Drosophila) (ENSG00000102243), score: 0.66 WDR72WD repeat domain 72 (ENSG00000166415), score: 0.49 WDR91WD repeat domain 91 (ENSG00000105875), score: 0.48 XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound (ENSG00000122121), score: 0.55 ZNF518Bzinc finger protein 518B (ENSG00000178163), score: -0.49 ZNF599zinc finger protein 599 (ENSG00000153896), score: 0.47

Non-Entrez genes

Unknown, score:

Id	species	tissue	sex	individual
hsa_kd_f_ca1	hsa	kd	f	_
hsa_kd_m2_ca1	hsa	kd	m	2
hsa_kd_m1_ca1	hsa	kd	m	1