User:PedroMarquesVidal

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Contact

Pedro Marques-Vidal

Chef de Clinique Adjoint

Institut Universitaire de Médecine Sociale et Préventive, bureau 125

17, rue du Bugnon

1005 Lausanne

Phone: +41 21 314 72 65

Fax: +41 21 314 72 44

Email: Pedro-Manuel.Marques-Vidal@chuv.ch

Topic

TOPIC 1: The goal is to perform a genome-wide association study that will potentially identify SNPs that are related to liver abnormalities in obese subjects (NAFL or NASH) by a) performing a GWAS on liver abnormalities; b) search for interactions with body mass index or obesity of the potential candidate SNPs identified; c) perform a GWAS comparing obese subjects with and without hepatic abnormalities. The tool of choice for this project is logistic regression analysis and linear regression analysis. The student will learn the basics of regressing a given phenotype to a genotype and how this analysis is implemented on a computer to handle a large number of SNPs.

TOPIC 2: The goal is to perform a genome-wide association study that will potentially identify SNPs that are related to liver markers by a) performing a GWAS on liver markers; b) search for interactions with body mass index or alcohol consumption of the potential candidate SNPs identified; The tool of choice for this project is logistic regression analysis and linear regression analysis. The student will learn the basics of regressing a given phenotype to a genotype and how this analysis is implemented on a computer to handle a large number of SNPs.

References

TOPIC 1: Kotronen et al. (2009) A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans. Diabetologia 52:1056–1060