Difference between revisions of "User:PedroMarquesVidal"
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== Topic ==
 
== Topic ==
  
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Goal: The goal of the project is to perform a genome-wide association study that will potentially identify SNPs that are related to tobacco consumption and related phenotypes. Particular emphasis will be put on SNP tagging taste-specific genes such as the TAS2R.
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Goal: The goal of the project is to perform a genome-wide association study that will potentially identify SNPs that are related to cardiovascular risk and compare the results between genders
  
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Mathematical tools: The tool of choice for this project is logistic regression analysis. The student will learn the basics of regressing a given phenotype to a genotype and how this analysis is implemented on a computer to handle a large number of SNPs. If time permits the student will explore the effect of other phenotypes as covariables and/or environmental interactions.
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Mathematical tools: The tool of choice for this project is logistic regression analysis. The student will learn the basics of regressing a given phenotype to a genotype and how this analysis is implemented on a computer to handle a large number of SNPs.  
  
 
== References ==
 
== References ==
  
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Kim U, Wooding S, Ricci D, Jorde LB, Drayna D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat. 2005 Sep;26(3):199-204
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Silander K, Alanne M, Kristiansson K, Saarela O, Ripatti S, et al. (2008) Gender Differences in Genetic Risk Profiles for Cardiovascular Disease. PLoS ONE 3(10): e3615. doi:10.1371/journal.pone.0003615
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Mangold JE, Payne TJ, Ma JZ, Chen G, Li MD. Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. J Med Genet. 2008 Sep;45(9):578-82.
 
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Snedecor SM, Pomerleau CS, Mehringer AM, Ninowski R, Pomerleau OF. Differences in smoking-related variables based on phenylthiocarbamide "taster" status. Addict Behav. 2006 Dec;31(12):2309-12
 

Revision as of 16:37, 25 February 2010

Contact

Pedro Marques-Vidal

Chef de Clinique Adjoint

Institut Universitaire de Médecine Sociale et Préventive

17, rue du Bugnon

1005 Lausanne

Phone: +41 21 314 72 65

Fax: +41 21 314 73 73

Email: Pedro-Manuel.Marques-Vidal@chuv.ch

Topic

Goal: The goal of the project is to perform a genome-wide association study that will potentially identify SNPs that are related to cardiovascular risk and compare the results between genders

Mathematical tools: The tool of choice for this project is logistic regression analysis. The student will learn the basics of regressing a given phenotype to a genotype and how this analysis is implemented on a computer to handle a large number of SNPs.

References

Silander K, Alanne M, Kristiansson K, Saarela O, Ripatti S, et al. (2008) Gender Differences in Genetic Risk Profiles for Cardiovascular Disease. PLoS ONE 3(10): e3615. doi:10.1371/journal.pone.0003615

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