Difference between revisions of "User:PedroMarquesVidal"
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Pedro Marques-Vidal | Pedro Marques-Vidal | ||
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Chef de Clinique Adjoint | Chef de Clinique Adjoint | ||
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Institut Universitaire de Médecine Sociale et Préventive | Institut Universitaire de Médecine Sociale et Préventive | ||
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17, rue du Bugnon | 17, rue du Bugnon | ||
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1005 Lausanne | 1005 Lausanne | ||
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Phone: +41 21 314 72 65 | Phone: +41 21 314 72 65 | ||
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Fax: +41 21 314 73 73 | Fax: +41 21 314 73 73 | ||
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Email: Pedro-Manuel.Marques-Vidal@chuv.ch | Email: Pedro-Manuel.Marques-Vidal@chuv.ch | ||
Revision as of 12:21, 5 March 2009
Contact
Pedro Marques-Vidal
Chef de Clinique Adjoint
Institut Universitaire de Médecine Sociale et Préventive
17, rue du Bugnon
1005 Lausanne
Phone: +41 21 314 72 65
Fax: +41 21 314 73 73
Email: Pedro-Manuel.Marques-Vidal@chuv.ch
Topic
Goal: The goal of the project is to perform a genome-wide association study that will potentially identify SNPs that are related to tobacco consumption and related phenotypes. Particular emphasis will be put on SNP tagging taste-specific genes such as the TAS2R.
Mathematical tools: The tool of choice for this project is logistic regression analysis. The student will learn the basics of regressing a given phenotype to a genotype and how this analysis is implemented on a computer to handle a large number of SNPs. If time permits the student will explore the effect of other phenotypes as covariables and/or environmental interactions.
References
Kim U, Wooding S, Ricci D, Jorde LB, Drayna D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat. 2005 Sep;26(3):199-204
Mangold JE, Payne TJ, Ma JZ, Chen G, Li MD. Bitter taste receptor gene polymorphisms are an important factor in the development of nicotine dependence in African Americans. J Med Genet. 2008 Sep;45(9):578-82.
Snedecor SM, Pomerleau CS, Mehringer AM, Ninowski R, Pomerleau OF. Differences in smoking-related variables based on phenylthiocarbamide "taster" status. Addict Behav. 2006 Dec;31(12):2309-12
