Under-expression is coded with green,
over-expression with red color.
immune system process
Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
antigen processing and presentation of peptide antigen via MHC class I
The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.
response to stress
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
biological_process
Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.
response to external stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
antigen processing and presentation
The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
antigen processing and presentation of peptide antigen
The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.
response to stimulus
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
all
This term is the most general term possible
response to wounding
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
plasma membrane
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
membrane
Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
MHC class I protein complex
A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.
extracellular region
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
cellular_component
The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.
cell
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
macromolecular complex
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.
MHC protein complex
A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.
protein complex
Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
all
This term is the most general term possible
cell part
Any constituent part of a cell, the basic structural and functional unit of all organisms.
membrane part
Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
plasma membrane part
Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
MHC protein complex
A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.
molecular_function
Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.
signal transducer activity
Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.
receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
transmembrane receptor activity
Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.
MHC class I receptor activity
Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.
molecular transducer activity
The molecular function that accepts an input of one form and creates an output of a different form.
all
This term is the most general term possible
| Id | Pvalue | ExpCount | Count | Size | Term |
|---|---|---|---|---|---|
| 05332 | 2.346e-03 | 0.3516 | 5 | 21 | Graft-versus-host disease |
| 04940 | 5.542e-03 | 0.4353 | 5 | 26 | Type I diabetes mellitus |
| 05330 | 2.304e-02 | 0.3516 | 4 | 21 | Allograft rejection |
| 05320 | 2.626e-02 | 0.3683 | 4 | 22 | Autoimmune thyroid disease |
AGMATagmatine ureohydrolase (agmatinase) (219792_at), score: 0.78 AJAP1adherens junctions associated protein 1 (206460_at), score: -0.55 ANXA2P3annexin A2 pseudogene 3 (211241_at), score: 0.78 APOMapolipoprotein M (205682_x_at), score: 0.82 B4GALT5UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 (221484_at), score: -0.49 B4GALT6UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 (206233_at), score: 0.8 BCORL1BCL6 co-repressor-like 1 (219444_at), score: 0.83 BEND5BEN domain containing 5 (219670_at), score: 0.83 BRD3bromodomain containing 3 (203825_at), score: 0.78 C11orf20chromosome 11 open reading frame 20 (219883_at), score: 0.77 C1orf159chromosome 1 open reading frame 159 (219337_at), score: 0.78 C1orf61chromosome 1 open reading frame 61 (205103_at), score: 0.8 C1Rcomplement component 1, r subcomponent (212067_s_at), score: -0.51 C9orf33chromosome 9 open reading frame 33 (217130_at), score: 0.81 CCND2cyclin D2 (200953_s_at), score: 0.79 CCRL1chemokine (C-C motif) receptor-like 1 (220351_at), score: -0.67 CD302CD302 molecule (203799_at), score: -0.53 CDC42SE1CDC42 small effector 1 (218157_x_at), score: -0.5 CDH18cadherin 18, type 2 (206280_at), score: 0.81 CHD3chromodomain helicase DNA binding protein 3 (208807_s_at), score: 0.78 CLEC7AC-type lectin domain family 7, member A (221698_s_at), score: 0.89 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: -0.49 COL15A1collagen, type XV, alpha 1 (203477_at), score: -0.65 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: -0.57 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: -0.47 CTTNBP2NLCTTNBP2 N-terminal like (214731_at), score: 0.82 CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 6 (211295_x_at), score: 0.77 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: -0.57 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: -0.63 DUSP14dual specificity phosphatase 14 (203367_at), score: -0.5 EGLN2egl nine homolog 2 (C. elegans) (220956_s_at), score: 0.8 EPHB3EPH receptor B3 (1438_at), score: 0.85 EXD3exonuclease 3'-5' domain containing 3 (220838_at), score: 0.82 F10coagulation factor X (205620_at), score: -0.59 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: -0.53 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: -0.55 FLGfilaggrin (215704_at), score: 1 FNDC3Afibronectin type III domain containing 3A (202304_at), score: -0.49 GAP43growth associated protein 43 (204471_at), score: 0.95 GDF5growth differentiation factor 5 (206614_at), score: 0.83 GNALguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (206355_at), score: 0.81 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: -0.84 GSTT1glutathione S-transferase theta 1 (203815_at), score: -0.46 HBEGFheparin-binding EGF-like growth factor (203821_at), score: -0.46 HK2hexokinase 2 (202934_at), score: -0.62 HLA-Amajor histocompatibility complex, class I, A (213932_x_at), score: -0.5 HLA-Amajor histocompatibility complex, class I, A (217436_x_at), score: -0.46 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: -0.53 HLA-Emajor histocompatibility complex, class I, E (200904_at), score: -0.58 HLA-Fmajor histocompatibility complex, class I, F (204806_x_at), score: -0.53 HOXD11homeobox D11 (214604_at), score: 0.91 HOXD4homeobox D4 (205522_at), score: 0.77 HPCAL1hippocalcin-like 1 (205462_s_at), score: -0.54 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: -0.51 IFITM1interferon induced transmembrane protein 1 (9-27) (214022_s_at), score: -0.53 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: -0.79 IL6interleukin 6 (interferon, beta 2) (205207_at), score: -0.61 IL8interleukin 8 (211506_s_at), score: -0.52 ITIH2inter-alpha (globulin) inhibitor H2 (204987_at), score: 0.88 KANK1KN motif and ankyrin repeat domains 1 (213005_s_at), score: -0.44 KCNMB4potassium large conductance calcium-activated channel, subfamily M, beta member 4 (219287_at), score: 0.89 KIAA1644KIAA1644 (52837_at), score: -0.54 LHFPlipoma HMGIC fusion partner (218656_s_at), score: -0.67 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: -0.54 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: -0.45 LOC286434hypothetical protein LOC286434 (222196_at), score: 0.92 LOC730227hypothetical protein LOC730227 (215756_at), score: 0.82 LONRF3LON peptidase N-terminal domain and ring finger 3 (220009_at), score: 0.78 LPHN1latrophilin 1 (203488_at), score: 0.83 LY96lymphocyte antigen 96 (206584_at), score: -0.58 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: -0.55 MAN2B1mannosidase, alpha, class 2B, member 1 (209166_s_at), score: -0.5 MAP2K3mitogen-activated protein kinase kinase 3 (207667_s_at), score: -0.51 MBmyoglobin (204179_at), score: 0.81 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: -0.51 MEOX1mesenchyme homeobox 1 (205619_s_at), score: 0.82 MUC3Amucin 3A, cell surface associated (217117_x_at), score: 0.83 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: -0.53 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: -0.52 NFIBnuclear factor I/B (209290_s_at), score: 0.81 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: -0.61 NID1nidogen 1 (202008_s_at), score: -0.49 NOVA1neuro-oncological ventral antigen 1 (205794_s_at), score: 0.88 NPC1Niemann-Pick disease, type C1 (202679_at), score: -0.55 NPC2Niemann-Pick disease, type C2 (200701_at), score: -0.48 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: -0.55 NT5DC25'-nucleotidase domain containing 2 (218051_s_at), score: 0.83 OR10C1olfactory receptor, family 10, subfamily C, member 1 (221339_at), score: 0.79 OSTM1osteopetrosis associated transmembrane protein 1 (218196_at), score: -0.46 PDGFDplatelet derived growth factor D (219304_s_at), score: -0.48 PEG3paternally expressed 3 (209242_at), score: 0.82 PER1period homolog 1 (Drosophila) (36829_at), score: 0.82 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: -0.56 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: -0.63 PRB3proline-rich protein BstNI subfamily 3 (206998_x_at), score: 0.78 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: -0.54 PTPRNprotein tyrosine phosphatase, receptor type, N (204945_at), score: 0.78 RALGPS2Ral GEF with PH domain and SH3 binding motif 2 (220338_at), score: 0.87 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: -0.45 RCAN2regulator of calcineurin 2 (203498_at), score: -0.64 RGS3regulator of G-protein signaling 3 (203823_at), score: -0.55 RPS4Y1ribosomal protein S4, Y-linked 1 (201909_at), score: -0.5 RRADRas-related associated with diabetes (204802_at), score: -0.63 RRHretinal pigment epithelium-derived rhodopsin homolog (208314_at), score: 0.77 RUFY2RUN and FYVE domain containing 2 (219957_at), score: 0.78 RUNX1runt-related transcription factor 1 (209360_s_at), score: -0.45 S100A12S100 calcium binding protein A12 (205863_at), score: 0.8 SCPEP1serine carboxypeptidase 1 (218217_at), score: -0.45 SCRG1scrapie responsive protein 1 (205475_at), score: 0.81 SH2B2SH2B adaptor protein 2 (205367_at), score: 0.84 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: -0.46 SLC4A5solute carrier family 4, sodium bicarbonate cotransporter, member 5 (204296_at), score: 0.82 SOD3superoxide dismutase 3, extracellular (205236_x_at), score: -0.54 SOX11SRY (sex determining region Y)-box 11 (204914_s_at), score: 0.87 SOX12SRY (sex determining region Y)-box 12 (204432_at), score: 0.77 STOMstomatin (201060_x_at), score: -0.46 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: -0.59 TAC3tachykinin 3 (219992_at), score: 0.77 TBX3T-box 3 (219682_s_at), score: -0.5 TM2D1TM2 domain containing 1 (211703_s_at), score: -0.53 TMBIM4transmembrane BAX inhibitor motif containing 4 (219206_x_at), score: -0.48 TMEM41Btransmembrane protein 41B (212623_at), score: -0.59 TNFRSF11Btumor necrosis factor receptor superfamily, member 11b (204933_s_at), score: -0.47 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: -0.46 TPP1tripeptidyl peptidase I (200742_s_at), score: -0.58 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: -0.49 TRAF3IP2TRAF3 interacting protein 2 (215411_s_at), score: -0.5 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: -0.45 TRIM45tripartite motif-containing 45 (219923_at), score: 0.78 TRIM62tripartite motif-containing 62 (219272_at), score: 0.83 WDR41WD repeat domain 41 (218055_s_at), score: 0.8 WTAPWilms tumor 1 associated protein (210285_x_at), score: -0.54 ZMYM6zinc finger, MYM-type 6 (219924_s_at), score: -0.49 ZNF287zinc finger protein 287 (216453_at), score: 0.78
| Id | sample | Experiment | ExpName | Array | Syndrome | Cell.line |
|---|---|---|---|---|---|---|
| E-TABM-263-raw-cel-1515485651.cel | 1 | 6 | Cycle | hgu133a2 | none | Cycle 1 |
| 4Twin.CEL | 4 | 2 | DS-twin | hgu133plus2 | none | DS-twin 4 |
| 5CTwin.CEL | 5 | 2 | DS-twin | hgu133plus2 | Down | DS-twin 5 |
| t21b 08-03.CEL | 5 | 1 | DS-CC | hgu133a | Down | DS-CC 5 |
| t21c 08-03.CEL | 6 | 1 | DS-CC | hgu133a | Down | DS-CC 6 |
| 1Twin.CEL | 1 | 2 | DS-twin | hgu133plus2 | Down | DS-twin 1 |
| 2Twin.CEL | 2 | 2 | DS-twin | hgu133plus2 | none | DS-twin 2 |
| t21d 08-03.CEL | 7 | 1 | DS-CC | hgu133a | Down | DS-CC 7 |
| 6Twin.CEL | 6 | 2 | DS-twin | hgu133plus2 | none | DS-twin 6 |
