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metabolic process

The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.

immune system process

Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

defense response

Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.

lipid metabolic process

The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

cell motion

Any process involved in the controlled movement of a cell.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

response to stress

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

cell communication

Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

behavior

The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

locomotory behavior

The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.

biological_process

Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.

cell proliferation

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

response to external stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

cellular process

Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

cell migration

The orderly movement of cells from one site to another, often during the development of a multicellular organism or multicellular structure.

regulation of lipid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

multicellular organismal process

Any biological process, occurring at the level of a multicellular organism, pertinent to its function.

developmental process

A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

locomotion

Self-propelled movement of a cell or organism from one location to another.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

wound healing

The series of events that restore integrity to a damaged tissue, following an injury.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

response to chemical stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

primary metabolic process

The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

anatomical structure development

The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

response to stimulus

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

localization

Any process by which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in a specific location.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

localization of cell

Any process by which a cell is transported to, and/or maintained in, a specific location.

biological regulation

Any process that modulates the frequency, rate or extent of any biological process, quality or function.

all

This term is the most general term possible

multicellular organismal development

The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of immune system process

Any process that modulates the frequency, rate, or extent of an immune system process.

regulation of metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.

regulation of locomotion

Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.

positive regulation of biological process

Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of cellular process

Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

immune response

Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.

regulation of localization

Any process that modulates the frequency, rate or extent of any process by which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.

regulation of biological process

Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

cell motility

Any process involved in the controlled movement of a cell that results in translocation of the cell from one place to another.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

regulation of cell proliferation

Any process that modulates the frequency, rate or extent of cell proliferation.

positive regulation of cellular process

Any process that activates or increases the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

system development

The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.

regulation of cell motion

Any process that modulates the frequency, rate or extent of the movement of a cell.

response to wounding

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

chemotaxis

The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

cell motion

Any process involved in the controlled movement of a cell.

regulation of lipid metabolic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

positive regulation of cell proliferation

Any process that activates or increases the rate or extent of cell proliferation.

organ development

Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.

regulation of leukocyte migration

Any process that modulates the frequency, rate, or extent of leukocyte migration.

regulation of cell migration

Any process that modulates the frequency, rate or extent of cell migration.

leukocyte migration

The movement of leukocytes within or between different tissues and organs of the body.

inflammatory response

The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.

taxis

The directed movement of a motile cell or organism in response to an external stimulus.

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

membrane

Double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

MHC class I protein complex

A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.

extracellular region

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

cellular_component

The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together.

extracellular space

That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.

cell

The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.

macromolecular complex

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

protein complex

Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or carbohydrate groups.

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

all

This term is the most general term possible

extracellular region part

Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.

cell part

Any constituent part of a cell, the basic structural and functional unit of all organisms.

membrane part

Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.

plasma membrane part

Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

MHC protein complex

A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.

protein binding

Interacting selectively with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).

molecular_function

Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.

catalytic activity

Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

serine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

peptidase activity

Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.

receptor binding

Interacting selectively with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.

signal transducer activity

Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell.

receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity.

transmembrane receptor activity

Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle.

cytokine activity

Functions to control the survival, growth, differentiation and effector function of tissues and cells.

binding

The selective, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.

growth factor activity

The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.

peptidase activity, acting on L-amino acid peptides

Catalysis of the hydrolysis of peptide bonds formed between L-amino acids.

hydrolase activity

Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

serine hydrolase activity

Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

MHC class I receptor activity

Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.

molecular transducer activity

The molecular function that accepts an input of one form and creates an output of a different form.

all

This term is the most general term possible

serine-type peptidase activity

Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).

Id	Pvalue	ExpCount	Count	Size	Term
GO:0009611	6.711e-11	7.25	33 BMP2, C1R, C1RL, C1S, CCL2, CD55, CD97, CLEC7A, CTSB, CXCL1, CXCL2, CXCL3, F10, F3, FGF7, GAP43, HBEGF, HMOX1, IL1RAP, IL6, IL8, JMJD3, LY96, NFKB1, NINJ1, PDGFA, PLA2G4C, PLAUR, PPARD, PROS1, SOD2, THBD, TPST1	231	response to wounding
GO:0009605	3.228e-10	11.61	41 BHLHE40, BMP2, C1R, C1RL, C1S, CCL2, CCRL1, CD55, CD97, CLEC7A, CTSB, CXCL1, CXCL2, CXCL3, EGR2, F10, F3, FGF2, FGF7, GAP43, HBEGF, HMOX1, IL1RAP, IL6, IL8, JMJD3, LY96, NFKB1, NINJ1, NPC1, NR4A3, PDGFA, PLA2G4C, PLAUR, PPARD, PROS1, SOD2, STC1, THBD, TPST1, VEGFA	370	response to external stimulus
GO:0002376	4.609e-09	14.91	45 ABCA1, C1R, C1RL, C1S, CBLB, CCL2, CCRL1, CD55, CD97, CLEC7A, CSF1, CXCL1, CXCL2, CXCL3, DPP4, GCH1, GEM, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL11, IL1RAP, IL1RL1, IL6, IL8, JARID2, LIF, LY96, NFIL3, NFKB1, NP, OSTM1, PSMB8, RUNX1, SECTM1, SHB, SOD2, SOX4, TNFSF4, TRIM22, VEGFA	475	immune system process
GO:0006955	1.758e-07	9.259	32 C1R, C1RL, C1S, CBLB, CCL2, CCRL1, CD55, CD97, CLEC7A, CXCL1, CXCL2, CXCL3, GCH1, GEM, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, ICAM1, IL1RAP, IL1RL1, IL6, IL8, LIF, LY96, NFIL3, PSMB8, SECTM1, TNFSF4, TRIM22	295	immune response
GO:0032501	1.667e-06	51.73	90 ABCA1, ACSL1, ADRA2A, ANGPTL4, ANO1, AQP1, ATP2A2, BHLHE40, BMP2, CCL2, COL13A1, COL15A1, CREG1, CSF1, CST3, CXCL1, DCN, DES, DGKD, DKK2, EGR2, EGR3, F10, F3, FGF2, FGF7, FLG, FNDC3A, FOSB, GAA, GAP43, GCH1, GPNMB, HBEGF, HK2, HLX, HMOX1, HOXC10, HSPB7, HTR2A, IDUA, IL11, IL6, IL8, ITPR3, JARID2, LIF, MAN2B1, MEIS1, MEOX1, NFKB1, NINJ1, NKX3-1, NP, NPTX1, NR3C1, NR4A3, OSTM1, PDGFA, PLAUR, PPARD, PPL, PROS1, PTN, RPS4Y1, RUNX1, SECTM1, SEMA4G, SEMA5A, SHB, SLC19A2, SMARCC1, SOD2, SOX11, SOX4, SPRED2, SPRY2, SPRY4, TBX3, TCOF1, THBD, TNFAIP2, TNFRSF11B, TNS3, TNXB, TPP1, USP22, UTP3, VEGFA, ZMYM6	1648	multicellular organismal process
GO:0050896	2.506e-06	42.37	78 ADRA2A, ANGPTL4, BDKRB1, BHLHE40, BMP2, C1R, C1RL, C1S, CBLB, CCL2, CCRL1, CD55, CD97, CLEC7A, CST3, CTSB, CXCL1, CXCL2, CXCL3, DGKD, DPP4, EGLN2, EGR2, F10, F3, FGF2, FGF7, FOSB, GAA, GAP43, GCH1, GEM, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, HSPB7, HTR2A, ICAM1, IFITM1, IL1RAP, IL1RL1, IL6, IL8, JMJD3, LGALS3BP, LIF, LY96, MAN2B1, NFIL3, NFKB1, NINJ1, NLGN4X, NPC1, NR3C1, NR4A3, PDGFA, PLA2G4C, PLAUR, PPARD, PROS1, PSMB8, PTN, SECTM1, SOCS2, SOD2, SOD3, STC1, THBD, TNFSF4, TP53I11, TPST1, TRIB1, TRIM22, VEGFA	1350	response to stimulus
GO:0006954	1.261e-05	4.802	20 BMP2, C1R, C1RL, C1S, CCL2, CD55, CD97, CLEC7A, CXCL1, CXCL2, CXCL3, HMOX1, IL1RAP, IL6, IL8, JMJD3, LY96, NFKB1, PLA2G4C, TPST1	153	inflammatory response
GO:0007275	1.647e-05	40.3	73 ABCA1, ANGPTL4, ANO1, ATP2A2, BMP2, CCL2, COL13A1, COL15A1, CREG1, CSF1, CST3, CXCL1, DCN, DGKD, DKK2, EGR2, EGR3, FGF2, FGF7, FLG, FNDC3A, FOSB, GAA, GAP43, GPNMB, HBEGF, HLX, HMOX1, HOXC10, IDUA, IL11, IL6, IL8, JARID2, LIF, MEIS1, MEOX1, NFKB1, NINJ1, NKX3-1, NP, NPTX1, NR3C1, NR4A3, OSTM1, PDGFA, PPARD, PPL, PTN, RPS4Y1, RUNX1, SECTM1, SEMA4G, SEMA5A, SHB, SMARCC1, SOD2, SOX11, SOX4, SPRED2, SPRY2, SPRY4, TBX3, TCOF1, THBD, TNFAIP2, TNFRSF11B, TNS3, TPP1, USP22, UTP3, VEGFA, ZMYM6	1284	multicellular organismal development
GO:0007610	4.388e-05	5.21	20 CCL2, CCRL1, CXCL1, CXCL2, CXCL3, EGR2, FGF2, FOSB, GAA, HTR2A, IL6, IL8, MAN2B1, NLGN4X, NR4A3, PDGFA, PLAUR, PTN, SOD2, VEGFA	166	behavior
GO:0042127	5.457e-05	11.96	32 ADRA2A, BMP2, CCL2, CCND2, CSF1, CXCL1, FGF2, FGF7, GPNMB, HBEGF, HMOX1, HOXC10, HTR2A, IFITM1, IL11, IL6, IL8, JARID2, LIF, NAMPT, NP, PDGFA, PPAP2A, PTN, SOD2, SOX4, TBX3, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA	381	regulation of cell proliferation
GO:0008284	8.104e-05	5.932	21 ADRA2A, CCL2, CCND2, CSF1, FGF2, FGF7, HBEGF, HOXC10, HTR2A, IL11, IL6, LIF, NAMPT, NP, PDGFA, PTN, SOX4, TBX3, TNFSF4, TNS3, VEGFA	189	positive regulation of cell proliferation
GO:0006952	1.196e-04	8.255	25 BMP2, C1R, C1RL, C1S, CCL2, CD55, CD97, CLEC7A, CST3, CXCL1, CXCL2, CXCL3, GCH1, HLA-B, HMOX1, IL1RAP, IL1RL1, IL6, IL8, JMJD3, LGALS3BP, LY96, NFKB1, PLA2G4C, TPST1	263	defense response
GO:0032502	2.783e-04	59.73	92 ABCA1, ANGPTL4, ANO1, ATP2A2, BMP2, CASP1, CASP4, CCL2, CDC42SE1, COL13A1, COL15A1, CREG1, CSF1, CST3, CTSB, CXCL1, DCN, DGKD, DKK2, EGLN2, EGR2, EGR3, FGF2, FGF7, FLG, FNDC3A, FOSB, GAA, GAP43, GNPTAB, GPNMB, HBEGF, HLX, HMOX1, HOXC10, HTR2A, HTRA1, IDUA, IL11, IL6, IL8, JARID2, LIF, MEIS1, MEOX1, MTSS1, NET1, NFKB1, NINJ1, NKX3-1, NP, NPTX1, NR3C1, NR4A3, OSTM1, PDGFA, PHLDA1, PPARD, PPL, PTN, RPS4Y1, RUNX1, SECTM1, SEMA4G, SEMA5A, SERPINB2, SHB, SMARCC1, SOCS2, SOD2, SOX11, SOX4, SPRED2, SPRY2, SPRY4, TBX3, TCOF1, THBD, TM2D1, TNFAIP2, TNFAIP8, TNFRSF11B, TNFRSF1B, TNS3, TP53BP2, TPP1, TRAF3, USP22, UTP3, VEGFA, WISP2, ZMYM6	1903	developmental process
GO:0048513	2.943e-04	23.32	47 ABCA1, ANGPTL4, ATP2A2, BMP2, CCL2, COL15A1, CSF1, CST3, DCN, EGR2, EGR3, FGF2, FGF7, FNDC3A, GAA, GAP43, GPNMB, HBEGF, HMOX1, IDUA, IL11, IL6, IL8, JARID2, LIF, NFKB1, NINJ1, NP, NR3C1, NR4A3, OSTM1, PPARD, PPL, PTN, RUNX1, SECTM1, SEMA5A, SHB, SMARCC1, SOD2, SOX4, SPRY2, TBX3, TNFAIP2, TNFRSF11B, TNS3, VEGFA	743	organ development
GO:0042060	9.318e-04	2.511	12 F10, F3, GAP43, HBEGF, HMOX1, IL6, NINJ1, PDGFA, PLAUR, PPARD, PROS1, THBD	80	wound healing
GO:0006935	1.203e-03	2.166	11 CCL2, CCRL1, CXCL1, CXCL2, CXCL3, FGF2, IL6, IL8, PDGFA, PLAUR, VEGFA	69	chemotaxis
GO:0042330	1.203e-03	2.166	11 CCL2, CCRL1, CXCL1, CXCL2, CXCL3, FGF2, IL6, IL8, PDGFA, PLAUR, VEGFA	69	taxis
GO:0048518	1.525e-03	27.24	50 ABCA1, ABLIM3, ADRA2A, ANGPTL4, BMP2, C1R, C1RL, C1S, CASP1, CASP4, CCL2, CCND2, CD55, CSF1, ECM1, EGLN2, EGR2, FGF2, FGF7, HBEGF, HMOX1, HOXC10, HTR2A, ICAM1, IL11, IL6, IL8, LIF, MEOX1, NAMPT, NFKB1, NP, NR4A3, PDGFA, PPARD, PTN, RUNX1, SECTM1, SMARCC1, SOD2, SOX4, TBX3, TM2D1, TNFSF4, TNS3, TP53BP2, TRAF3, TRAF3IP2, USP22, VEGFA	868	positive regulation of biological process
GO:0008283	1.657e-03	17.73	37 ADRA2A, BMP2, CCL2, CCND2, CREG1, CSF1, CXCL1, FGF2, FGF7, GPNMB, HBEGF, HMOX1, HOXC10, HTR2A, IFITM1, IL11, IL15RA, IL6, IL8, JARID2, LIF, NAMPT, NP, PDGFA, PDGFD, PPAP2A, PPARD, PTN, SHB, SOD2, SOX4, TBX3, TNFSF4, TNS3, TP53I11, TRIB1, VEGFA	565	cell proliferation
GO:0007626	1.914e-03	3.17	13 CCL2, CCRL1, CXCL1, CXCL2, CXCL3, FGF2, GAA, IL6, IL8, PDGFA, PLAUR, SOD2, VEGFA	101	locomotory behavior
GO:0006950	2.249e-03	26.93	49 ADRA2A, ANGPTL4, BMP2, C1R, C1RL, C1S, CCL2, CD55, CD97, CLEC7A, CST3, CTSB, CXCL1, CXCL2, CXCL3, DPP4, EGLN2, F10, F3, FGF7, GAP43, GCH1, HBEGF, HLA-B, HMOX1, HSPB7, HTR2A, IL1RAP, IL1RL1, IL6, IL8, JMJD3, LGALS3BP, LY96, NFKB1, NINJ1, NPC1, PDGFA, PLA2G4C, PLAUR, PPARD, PROS1, SOD2, SOD3, THBD, TP53I11, TPST1, TRIB1, VEGFA	858	response to stress
GO:0048731	4.297e-03	31.67	54 ABCA1, ANGPTL4, ATP2A2, BMP2, CCL2, COL15A1, CSF1, CST3, CXCL1, DCN, EGR2, EGR3, FGF2, FGF7, FNDC3A, GAA, GAP43, GPNMB, HBEGF, HMOX1, HOXC10, IDUA, IL11, IL6, IL8, JARID2, LIF, NFKB1, NINJ1, NP, NPTX1, NR3C1, NR4A3, OSTM1, PPARD, PPL, PTN, RUNX1, SECTM1, SEMA4G, SEMA5A, SHB, SMARCC1, SOD2, SOX11, SOX4, SPRY2, TBX3, TCOF1, TNFAIP2, TNFRSF11B, TNS3, TPP1, VEGFA	1009	system development
GO:0007154	5.743e-03	61.11	88 ABCA1, ADRA2A, ANGPTL4, ASAP2, ATP2A2, BDKRB1, BHLHE40, BMP2, CASP1, CBLB, CCL2, CCRL1, CD97, CDC42SE1, CLEC7A, CXCL1, DGKD, DKK2, ECM1, EGLN2, EGR2, EGR3, FGF2, FGF7, GAP43, GEM, GNAL, GPR37, GRN, HBEGF, HMOX1, HTR2A, HTRA1, IFITM1, IL11, IL15RA, IL1RAP, IL1RL1, IL6, IL8, ITPR3, LGALS3BP, LGR4, LIF, LY96, MFAP4, MTSS1, NAMPT, NET1, NFATC1, NFKB1, NPC1, NPTX1, NR3C1, PDGFA, PIK3CD, PLA2G4C, PLAUR, PMEPA1, PPAP2A, PPARD, PTN, RAPGEF2, RCAN2, RGS3, RRAD, SECTM1, SEMA5A, SHB, SOCS2, SOD2, SOX4, SPRED2, SPRY2, SPRY4, STC1, STK38L, TBX3, TEX2, TNFRSF11B, TNFSF4, TNXB, TP53BP2, TRAF3, TRAF3IP2, TRIB1, VEGFA, WISP2	1947	cell communication
GO:0048856	6.064e-03	38.7	62 ABCA1, ANGPTL4, ATP2A2, BMP2, CCL2, CDC42SE1, COL15A1, CSF1, CST3, CXCL1, DCN, DGKD, EGLN2, EGR2, EGR3, FGF2, FGF7, FNDC3A, GAA, GAP43, GPNMB, HBEGF, HMOX1, HOXC10, HTRA1, IDUA, IL11, IL6, IL8, JARID2, LIF, MTSS1, NET1, NFKB1, NINJ1, NP, NPTX1, NR3C1, NR4A3, OSTM1, PPARD, PPL, PTN, RUNX1, SECTM1, SEMA4G, SEMA5A, SHB, SMARCC1, SOCS2, SOD2, SOX11, SOX4, SPRY2, TBX3, TCOF1, TNFAIP2, TNFRSF11B, TNS3, TPP1, VEGFA, WISP2	1233	anatomical structure development
GO:0040011	8.774e-03	7.156	19 CCL2, CCRL1, CSF1, CXCL1, CXCL2, CXCL3, FGF2, HBEGF, HMOX1, ICAM1, IL6, IL8, PDGFA, PLAUR, PPAP2A, PPARD, TNS3, TRIB1, VEGFA	228	locomotion
GO:0006928	9.404e-03	8.443	21 ADRA2A, CCL2, CD97, CSF1, EGR2, FGF2, GAP43, HBEGF, HMOX1, ICAM1, IL6, IL8, MTSS1, PDGFA, PLAUR, PPAP2A, PPARD, SEMA5A, TNS3, TRIB1, VEGFA	269	cell motion
GO:0051674	9.404e-03	8.443	21 ADRA2A, CCL2, CD97, CSF1, EGR2, FGF2, GAP43, HBEGF, HMOX1, ICAM1, IL6, IL8, MTSS1, PDGFA, PLAUR, PPAP2A, PPARD, SEMA5A, TNS3, TRIB1, VEGFA	269	localization of cell
GO:0019216	9.765e-03	1.13	7 ABCA1, ACSL1, NFKB1, NPC2, NR3C1, PDGFA, PPAP2A	36	regulation of lipid metabolic process
GO:0002685	9.781e-03	0.2825	4 HMOX1, ICAM1, IL6, VEGFA	9	regulation of leukocyte migration
GO:0009887	1.024e-02	9.793	23 ANGPTL4, BMP2, CCL2, COL15A1, CST3, DCN, FGF2, GAA, HMOX1, IDUA, IL6, IL8, JARID2, NR4A3, SEMA5A, SHB, SMARCC1, SOD2, SPRY2, TBX3, TNFAIP2, TNFRSF11B, VEGFA	312	organ morphogenesis
GO:0007155	1.040e-02	11.8	26 AEBP1, AJAP1, ATP2A2, CCL2, CD97, COL13A1, COL14A1, COL15A1, CSF1, DPP4, DPT, FNDC3A, GPNMB, ICAM1, IL8, LGALS3BP, MTSS1, NID1, NINJ1, NLGN4X, PKP2, PPARD, SCARB2, SEMA5A, SVEP1, WISP2	376	cell adhesion
GO:0022610	1.040e-02	11.8	26 AEBP1, AJAP1, ATP2A2, CCL2, CD97, COL13A1, COL14A1, COL15A1, CSF1, DPP4, DPT, FNDC3A, GPNMB, ICAM1, IL8, LGALS3BP, MTSS1, NID1, NINJ1, NLGN4X, PKP2, PPARD, SCARB2, SEMA5A, SVEP1, WISP2	376	biological adhesion
GO:0065007	1.049e-02	118.3	146 ABCA1, ABLIM3, ACSL1, ADRA2A, AEBP1, ANGPTL4, ASAP2, ATP2A2, BDKRB1, BHLHE40, BMP2, C13orf15, C1R, C1RL, C1S, CASP1, CASP4, CBLB, CCL2, CCND2, CCRL1, CD55, CD97, CDC42SE1, CLEC7A, CREG1, CSF1, CST3, CTSB, CXCL1, DES, DGKD, DKK2, DPP4, ECM1, EGLN2, EGR2, EGR3, F10, F3, FGF2, FGF7, FOSB, GAA, GAP43, GCH1, GEM, GNAL, GPNMB, GPR37, GRN, HBEGF, HLX, HMOX1, HOXC10, HSD17B11, HSPB7, HTR2A, HTRA1, ICAM1, IDUA, IFITM1, IL11, IL15RA, IL1RAP, IL1RL1, IL6, IL8, ITPR3, JARID2, JMJD3, KANK1, KHDRBS3, LGALS3BP, LGR4, LIF, LMCD1, LY96, MEIS1, MEIS3P1, MEOX1, MFAP4, MTSS1, NAMPT, NET1, NFATC1, NFIL3, NFKB1, NKX3-1, NP, NPC1, NPC2, NR3C1, NR4A3, PDGFA, PDGFD, PIK3CD, PLA2G4C, PLAUR, PMEPA1, PPAP2A, PPARD, PROS1, PSMB8, PTN, RAPGEF2, RCAN2, RGS3, RRAD, RUNX1, SECTM1, SERPINB2, SHB, SMARCC1, SOCS2, SOD2, SOX11, SOX4, SPRED2, SPRY2, SPRY4, STC1, STK38L, TBX3, TEX2, THBD, TM2D1, TNFAIP8, TNFRSF11B, TNFSF4, TNS3, TNXB, TP53BP2, TP53I11, TPP1, TRAF3, TRAF3IP2, TRIB1, TRIM22, USP22, VEGFA, WISP2, ZBTB20, ZKSCAN3, ZNF35, ZNF672	3768	biological regulation
GO:0010646	1.051e-02	13.18	28 ASAP2, BHLHE40, BMP2, CASP1, DKK2, ECM1, EGR2, HMOX1, HTR2A, HTRA1, IL11, IL1RL1, IL6, LIF, NET1, NPC1, PPARD, RAPGEF2, RGS3, SECTM1, SOCS2, SOX4, SPRED2, SPRY2, SPRY4, TRAF3IP2, TRIB1, VEGFA	420	regulation of cell communication
GO:0033135	1.079e-02	0.1255	3 IL11, IL6, LIF	4	regulation of peptidyl-serine phosphorylation
GO:0033138	1.079e-02	0.1255	3 IL11, IL6, LIF	4	positive regulation of peptidyl-serine phosphorylation
GO:0002237	1.168e-02	0.5336	5 BDKRB1, GCH1, IL6, THBD, TRIB1	17	response to molecule of bacterial origin
GO:0002474	1.168e-02	0.5336	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	17	antigen processing and presentation of peptide antigen via MHC class I
GO:0007165	1.313e-02	56.5	81 ABCA1, ADRA2A, ANGPTL4, ASAP2, ATP2A2, BDKRB1, BMP2, CASP1, CBLB, CCL2, CCRL1, CD97, CDC42SE1, CLEC7A, CXCL1, DGKD, DKK2, ECM1, EGLN2, FGF2, FGF7, GAP43, GEM, GNAL, GPR37, GRN, HBEGF, HMOX1, HTR2A, HTRA1, IFITM1, IL11, IL15RA, IL1RAP, IL1RL1, IL6, IL8, ITPR3, LGALS3BP, LGR4, LIF, LY96, MFAP4, MTSS1, NAMPT, NET1, NFATC1, NFKB1, NR3C1, PDGFA, PIK3CD, PLA2G4C, PLAUR, PMEPA1, PPAP2A, PPARD, PTN, RAPGEF2, RCAN2, RGS3, RRAD, SECTM1, SHB, SOCS2, SOD2, SOX4, SPRED2, SPRY2, SPRY4, STC1, STK38L, TEX2, TNFRSF11B, TNFSF4, TNXB, TP53BP2, TRAF3, TRAF3IP2, TRIB1, VEGFA, WISP2	1800	signal transduction
GO:0030335	1.470e-02	1.224	7 CSF1, FGF2, HBEGF, ICAM1, IL6, PDGFA, VEGFA	39	positive regulation of cell migration
GO:0019882	1.666e-02	1.255	7 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, ICAM1, PSMB8	40	antigen processing and presentation
GO:0040012	1.894e-02	2.605	10 CSF1, FGF2, HBEGF, HMOX1, ICAM1, IL6, IL8, PDGFA, TRIB1, VEGFA	83	regulation of locomotion
GO:0065008	1.982e-02	20.5	37 ABCA1, ATP2A2, BDKRB1, CCL2, CD55, CDC42SE1, DGKD, EGLN2, EGR2, F10, F3, GAA, GCH1, HMOX1, HSD17B11, HTR2A, HTRA1, IDUA, IL11, IL6, ITPR3, LIF, NET1, NPC1, NPC2, NR3C1, PDGFA, PLAUR, PROS1, SOCS2, SOD2, STC1, TBX3, THBD, TPP1, VEGFA, WISP2	653	regulation of biological quality
GO:0006959	2.083e-02	0.9416	6 C1R, C1RL, C1S, CCL2, CD55, IL6	30	humoral immune response
GO:0050900	2.083e-02	0.9416	6 CCL2, HMOX1, ICAM1, IL6, IL8, VEGFA	30	leukocyte migration
GO:0048522	2.225e-02	25.33	43 ABCA1, ABLIM3, ADRA2A, BMP2, CASP1, CASP4, CCL2, CCND2, CSF1, ECM1, EGR2, FGF2, FGF7, HBEGF, HMOX1, HOXC10, HTR2A, ICAM1, IL11, IL6, LIF, MEOX1, NAMPT, NFKB1, NP, NR4A3, PDGFA, PPARD, PTN, RUNX1, SECTM1, SMARCC1, SOD2, SOX4, TBX3, TM2D1, TNFSF4, TNS3, TP53BP2, TRAF3, TRAF3IP2, USP22, VEGFA	807	positive regulation of cellular process
GO:0009888	2.290e-02	4.834	14 ATP2A2, BMP2, CST3, FGF7, GAA, GAP43, GPNMB, NINJ1, NR4A3, PPARD, PPL, PTN, SECTM1, TBX3	154	tissue development
GO:0051272	2.641e-02	1.381	7 CSF1, FGF2, HBEGF, ICAM1, IL6, PDGFA, VEGFA	44	positive regulation of cell motion
GO:0048002	2.657e-02	0.6591	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	21	antigen processing and presentation of peptide antigen
GO:0051239	2.800e-02	10.04	22 ANGPTL4, ATP2A2, BHLHE40, BMP2, CSF1, CST3, DES, EGR2, FGF2, GAA, HBEGF, HMOX1, HSPB7, HTR2A, IL6, LIF, NFKB1, NP, PDGFA, RUNX1, TBX3, TNFRSF11B	320	regulation of multicellular organismal process
GO:0030334	3.239e-02	2.354	9 CSF1, FGF2, HBEGF, HMOX1, ICAM1, IL6, PDGFA, TRIB1, VEGFA	75	regulation of cell migration
GO:0050789	3.276e-02	112.2	137 ABCA1, ABLIM3, ACSL1, ADRA2A, AEBP1, ANGPTL4, ASAP2, ATP2A2, BDKRB1, BHLHE40, BMP2, C13orf15, C1R, C1RL, C1S, CASP1, CASP4, CBLB, CCL2, CCND2, CCRL1, CD55, CD97, CDC42SE1, CLEC7A, CREG1, CSF1, CST3, CTSB, CXCL1, DES, DGKD, DKK2, DPP4, ECM1, EGLN2, EGR2, EGR3, FGF2, FGF7, FOSB, GAA, GAP43, GEM, GNAL, GPNMB, GPR37, GRN, HBEGF, HLX, HMOX1, HOXC10, HSPB7, HTR2A, HTRA1, ICAM1, IFITM1, IL11, IL15RA, IL1RAP, IL1RL1, IL6, IL8, ITPR3, JARID2, JMJD3, KANK1, KHDRBS3, LGALS3BP, LGR4, LIF, LMCD1, LY96, MEIS1, MEIS3P1, MEOX1, MFAP4, MTSS1, NAMPT, NET1, NFATC1, NFIL3, NFKB1, NKX3-1, NP, NPC1, NPC2, NR3C1, NR4A3, PDGFA, PDGFD, PIK3CD, PLA2G4C, PLAUR, PMEPA1, PPAP2A, PPARD, PTN, RAPGEF2, RCAN2, RGS3, RRAD, RUNX1, SECTM1, SERPINB2, SHB, SMARCC1, SOCS2, SOD2, SOX11, SOX4, SPRED2, SPRY2, SPRY4, STC1, STK38L, TBX3, TEX2, TM2D1, TNFAIP8, TNFRSF11B, TNFSF4, TNS3, TNXB, TP53BP2, TP53I11, TRAF3, TRAF3IP2, TRIB1, TRIM22, USP22, VEGFA, WISP2, ZBTB20, ZKSCAN3, ZNF35, ZNF672	3574	regulation of biological process
GO:0002763	3.318e-02	0.408	4 CSF1, LIF, NFKB1, RUNX1	13	positive regulation of myeloid leukocyte differentiation
GO:0050905	3.640e-02	0.7219	5 GAA, GCH1, HOXC10, NR4A3, TPP1	23	neuromuscular process
GO:0001934	3.875e-02	1.099	6 BMP2, CCND2, FGF2, IL11, IL6, LIF	35	positive regulation of protein amino acid phosphorylation
GO:0007267	3.929e-02	8.38	19 BHLHE40, BMP2, CD97, EGR2, EGR3, FGF2, HTR2A, IL11, IL6, IL8, LIF, NAMPT, NPTX1, PDGFA, SEMA5A, SPRY2, STC1, TBX3, WISP2	267	cell-cell signaling
GO:0009966	4.000e-02	11.83	24 ASAP2, BMP2, CASP1, DKK2, ECM1, HMOX1, HTRA1, IL11, IL1RL1, IL6, LIF, NET1, PPARD, RAPGEF2, RGS3, SECTM1, SOCS2, SOX4, SPRED2, SPRY2, SPRY4, TRAF3IP2, TRIB1, VEGFA	377	regulation of signal transduction
GO:0006958	4.117e-02	0.4394	4 C1R, C1RL, C1S, CD55	14	complement activation, classical pathway
GO:0032496	4.117e-02	0.4394	4 BDKRB1, GCH1, THBD, TRIB1	14	response to lipopolysaccharide
GO:0002682	4.266e-02	4.677	13 C1R, C1RL, C1S, CD55, CSF1, HMOX1, ICAM1, IL6, LIF, NFKB1, NP, RUNX1, VEGFA	149	regulation of immune system process
GO:0007596	4.540e-02	1.569	7 F10, F3, IL6, PDGFA, PLAUR, PROS1, THBD	50	blood coagulation
GO:0050817	4.540e-02	1.569	7 F10, F3, IL6, PDGFA, PLAUR, PROS1, THBD	50	coagulation
GO:0045087	4.659e-02	2.04	8 C1R, C1RL, C1S, CD55, CLEC7A, GCH1, IL1RAP, IL1RL1	65	innate immune response
GO:0048869	4.741e-02	25.86	42 ABCA1, ANGPTL4, BMP2, CDC42SE1, COL13A1, COL15A1, CSF1, DGKD, EGLN2, EGR2, FGF2, FLG, FNDC3A, GAP43, GNPTAB, GPNMB, HLX, HOXC10, HTRA1, IDUA, IL11, IL6, LIF, MTSS1, NET1, NFKB1, NP, OSTM1, PPARD, PPL, RUNX1, SEMA4G, SEMA5A, SHB, SOCS2, SOD2, SOX4, SPRY2, TBX3, TNFAIP2, VEGFA, WISP2	824	cellular developmental process
GO:0044057	4.745e-02	2.542	9 ATP2A2, BHLHE40, DES, EGR2, GAA, HBEGF, HMOX1, HSPB7, HTR2A	81	regulation of system process
GO:0016477	4.757e-02	5.367	14 CCL2, CSF1, FGF2, HBEGF, HMOX1, ICAM1, IL6, IL8, PDGFA, PPAP2A, PPARD, TNS3, TRIB1, VEGFA	171	cell migration
GO:0042221	4.837e-02	13.53	26 BDKRB1, CCL2, CCRL1, CLEC7A, CXCL1, CXCL2, CXCL3, DGKD, EGR2, FGF2, GCH1, HMOX1, HSPB7, HTR2A, IL6, IL8, NPC1, NR3C1, PDGFA, PLAUR, SOCS2, SOD2, STC1, THBD, TRIB1, VEGFA	431	response to chemical stimulus
GO:0007166	4.840e-02	21.91	37 ABCA1, ADRA2A, BDKRB1, BMP2, CBLB, CCL2, CCRL1, CD97, CXCL1, DGKD, DKK2, FGF2, FGF7, GAP43, GEM, GNAL, GPR37, HBEGF, HTR2A, HTRA1, IFITM1, IL6, IL8, ITPR3, LGR4, LIF, LY96, MTSS1, PDGFA, PPAP2A, PTN, RGS3, SOCS2, SOX4, STC1, TRIB1, VEGFA	698	cell surface receptor linked signal transduction
GO:0006478	4.909e-02	0.06277	2 TPST1, TPST2	2	peptidyl-tyrosine sulfation
GO:0010713	4.909e-02	0.06277	2 CST3, IL6	2	negative regulation of collagen metabolic process
GO:0044252	4.909e-02	0.06277	2 CST3, IL6	2	negative regulation of multicellular organismal metabolic process
GO:0002455	4.912e-02	0.4708	4 C1R, C1RL, C1S, CD55	15	humoral immune response mediated by circulating immunoglobulin

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005576	1.786e-18	21.1	71 AEBP1, ANGPTL4, APOD, BMP2, C1R, C1RL, C1S, CCL2, CD97, COL13A1, COL14A1, COL15A1, CREG1, CSF1, CST3, CTSB, CTSL1, CXCL1, CXCL2, CXCL3, DCN, DKK2, DPP4, DPT, ECM1, F10, FGF2, FGF7, GRN, HBEGF, HLA-C, HMOX1, HSD17B11, HTRA1, ICAM1, IL11, IL15RA, IL1RAP, IL1RL1, IL33, IL6, IL8, ITIH2, LGALS3BP, LIF, LY96, MFAP4, MUC3A, NID1, NPC2, OLFML2A, PDGFA, PDGFD, PLAUR, PROS1, PTGDS, PTN, SCPEP1, SECTM1, SERPINB2, SOD3, STC1, SVEP1, THBD, TNFAIP2, TNFRSF11B, TNFRSF1B, TNFSF4, TNXB, VEGFA, WISP2	700	extracellular region
GO:0044421	6.911e-12	11.67	43 ANGPTL4, APOD, BMP2, C1RL, CCL2, COL13A1, COL14A1, COL15A1, CSF1, CST3, CXCL1, CXCL2, CXCL3, DCN, DKK2, DPT, ECM1, FGF2, GRN, HBEGF, HMOX1, HTRA1, ICAM1, IL11, IL33, IL6, IL8, LGALS3BP, LIF, MFAP4, NID1, OLFML2A, PDGFA, PTN, SECTM1, SOD3, STC1, THBD, TNFAIP2, TNFRSF11B, TNFSF4, TNXB, VEGFA	387	extracellular region part
GO:0005615	2.099e-10	7.416	32 ANGPTL4, APOD, BMP2, C1RL, CCL2, CSF1, CST3, CXCL1, CXCL2, CXCL3, DKK2, FGF2, GRN, HBEGF, HMOX1, HTRA1, ICAM1, IL11, IL33, IL6, IL8, LGALS3BP, LIF, PDGFA, PTN, SECTM1, SOD3, STC1, THBD, TNFAIP2, TNFSF4, VEGFA	246	extracellular space
GO:0042612	2.151e-03	0.4522	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	15	MHC class I protein complex
GO:0042611	1.213e-02	0.6632	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	22	MHC protein complex
GO:0031012	1.352e-02	5.004	14 ANGPTL4, COL13A1, COL14A1, COL15A1, DCN, DPT, ECM1, LGALS3BP, MFAP4, NID1, OLFML2A, TNFRSF11B, TNXB, VEGFA	166	extracellular matrix
GO:0005886	1.585e-02	43.5	64 ABCA1, ADRA2A, AJAP1, AQP1, ASAP2, ATP2A2, BDKRB1, CADPS2, CCRL1, CD55, CD97, CDC42SE1, CLEC2B, COL13A1, CSF1, CTSB, DDX3Y, DES, DGKD, DPP4, F10, F3, GAP43, GEM, GPNMB, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HTR2A, ICAM1, IFITM1, IL1RAP, IL1RL1, IL6, ITPR3, LGR4, LY96, MAGI2, NLGN4X, NPC1, PKP2, PLAUR, PMEPA1, PPAP2A, PPL, RAPGEF2, RGS3, SCARB2, SECTM1, SHB, SLC19A2, SPRED2, SPRY2, SPRY4, STOM, THBD, TM2D1, TNFRSF1B, TNFSF4, TNS3	1443	plasma membrane
GO:0005578	2.205e-02	4.703	13 ANGPTL4, COL13A1, COL14A1, COL15A1, DCN, DPT, ECM1, LGALS3BP, MFAP4, NID1, TNFRSF11B, TNXB, VEGFA	156	proteinaceous extracellular matrix
GO:0000323	4.419e-02	3.376	10 CTSA, CTSB, CTSK, GAA, IDUA, MAN2B1, NPC1, NPC2, SCARB2, TPP1	112	lytic vacuole
GO:0005764	4.419e-02	3.376	10 CTSA, CTSB, CTSK, GAA, IDUA, MAN2B1, NPC1, NPC2, SCARB2, TPP1	112	lysosome

Id	Pvalue	ExpCount	Count	Size	Term
GO:0005125	6.447e-07	2.19	16 BMP2, CCL2, CSF1, CXCL1, CXCL2, GRN, IL11, IL33, IL6, IL8, LIF, NAMPT, SECTM1, TNFRSF11B, TNFSF4, VEGFA	73	cytokine activity
GO:0008083	2.330e-04	2.82	14 BMP2, CSF1, CXCL1, FGF2, FGF7, GRN, HBEGF, IL11, IL6, LIF, PDGFA, PDGFD, PTN, VEGFA	94	growth factor activity
GO:0005102	4.392e-04	12.24	31 ANGPTL4, BMP2, CCL2, CLEC7A, CSF1, CXCL1, CXCL2, FGF2, FGF7, GPNMB, GRN, HBEGF, ICAM1, IL11, IL33, IL6, IL8, LIF, MFAP4, MTSS1, NAMPT, PDGFA, PDGFD, PSMB8, PTN, SECTM1, SOCS2, STC1, TNFRSF11B, TNFSF4, VEGFA	408	receptor binding
GO:0032393	7.197e-04	0.27	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	9	MHC class I receptor activity
GO:0004871	9.272e-04	23.94	47 ABCA1, ADRA2A, BDKRB1, CBLB, CCL2, CCRL1, CD97, CLEC7A, ECM1, GNAL, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, HTR2A, ICAM1, IFITM1, IL15RA, IL1RAP, IL1RL1, ITPR3, LGALS3BP, LGR4, LY96, NPC1, NR3C1, NR4A3, PLAUR, PPARD, RAPGEF2, RGS3, SCARB2, SECTM1, SEMA4G, SEMA5A, SHB, SOCS2, THBD, TM2D1, TNFRSF11B, TNFRSF1B, TP53BP2, TRAF3	798	signal transducer activity
GO:0060089	9.272e-04	23.94	47 ABCA1, ADRA2A, BDKRB1, CBLB, CCL2, CCRL1, CD97, CLEC7A, ECM1, GNAL, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HMOX1, HTR2A, ICAM1, IFITM1, IL15RA, IL1RAP, IL1RL1, ITPR3, LGALS3BP, LGR4, LY96, NPC1, NR3C1, NR4A3, PLAUR, PPARD, RAPGEF2, RGS3, SCARB2, SECTM1, SEMA4G, SEMA5A, SHB, SOCS2, THBD, TM2D1, TNFRSF11B, TNFRSF1B, TP53BP2, TRAF3	798	molecular transducer activity
GO:0004872	3.490e-03	15.99	34 ABCA1, ADRA2A, BDKRB1, CCRL1, CD97, CLEC7A, GPR37, HBEGF, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HTR2A, ICAM1, IL15RA, IL1RAP, IL1RL1, ITPR3, LGALS3BP, LGR4, LY96, NPC1, NR3C1, NR4A3, PLAUR, PPARD, SCARB2, SEMA4G, SEMA5A, THBD, TM2D1, TNFRSF11B, TNFRSF1B	533	receptor activity
GO:0008236	3.957e-03	1.98	10 C1R, C1RL, C1S, CTSA, DPP4, F10, HTRA1, SCPEP1, SERPINB2, TPP1	66	serine-type peptidase activity
GO:0017171	3.957e-03	1.98	10 C1R, C1RL, C1S, CTSA, DPP4, F10, HTRA1, SCPEP1, SERPINB2, TPP1	66	serine hydrolase activity
GO:0004252	2.095e-02	1.65	8 C1R, C1RL, C1S, DPP4, F10, HTRA1, SERPINB2, TPP1	55	serine-type endopeptidase activity
GO:0004175	2.944e-02	5.431	15 C1R, C1RL, C1S, CASP1, CASP4, CTSB, CTSK, CTSL1, CTSO, DPP4, F10, HTRA1, PSMB8, SERPINB2, TPP1	181	endopeptidase activity
GO:0008201	3.285e-02	1.38	7 COL13A1, FGF2, GPNMB, HBEGF, PTN, SOD3, VEGFA	46	heparin binding
GO:0004888	3.406e-02	10.02	22 ADRA2A, BDKRB1, CCRL1, CD97, GPR37, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HTR2A, ICAM1, IL15RA, IL1RAP, IL1RL1, LGALS3BP, LGR4, NPC1, SEMA5A, THBD, TM2D1, TNFRSF1B	334	transmembrane receptor activity
GO:0030246	4.272e-02	3.961	12 CD302, CLEC2B, CLEC7A, COL13A1, FGF2, GAA, GPNMB, HBEGF, MAN2B1, PTN, SOD3, VEGFA	132	carbohydrate binding
GO:0070011	4.392e-02	8.281	19 AEBP1, C1R, C1RL, C1S, CASP1, CASP4, CTSA, CTSB, CTSK, CTSL1, CTSO, DPP4, F10, HTRA1, PSMB8, SCPEP1, SERPINB2, TPP1, USP22	276	peptidase activity, acting on L-amino acid peptides

Id	Pvalue	ExpCount	Count	Size	Term
04060	2.759e-04	4.565	17 BMP2, CCL2, CSF1, CXCL1, CXCL2, CXCL3, IL11, IL15RA, IL1RAP, IL6, IL8, LIF, PDGFA, TNFRSF11B, TNFRSF1B, TNFSF4, VEGFA	122	Cytokine-cytokine receptor interaction
04610	4.339e-04	1.272	9 BDKRB1, C1R, C1S, CD55, F10, F3, PLAUR, PROS1, THBD	34	Complement and coagulation cascades
05332	8.054e-03	0.7858	6 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, IL6	21	Graft-versus-host disease
04630	2.369e-02	3.293	11 CBLB, CCND2, IL11, IL15RA, IL6, LIF, PIK3CD, SOCS2, SPRED2, SPRY2, SPRY4	88	Jak-STAT signaling pathway
05330	4.694e-02	0.7858	5 HLA-A, HLA-B, HLA-C, HLA-E, HLA-F	21	Allograft rejection

No enriched terms

No enriched terms

Entrez genes

ABCA1ATP-binding cassette, sub-family A (ABC1), member 1 (203504_s_at), score: 0.19 ABLIM3actin binding LIM protein family, member 3 (205730_s_at), score: 0.21 ACSL1acyl-CoA synthetase long-chain family member 1 (201963_at), score: 0.24 ADH1Balcohol dehydrogenase 1B (class I), beta polypeptide (209612_s_at), score: 0.37 ADRA2Aadrenergic, alpha-2A-, receptor (209869_at), score: 0.42 AEBP1AE binding protein 1 (201792_at), score: 0.21 AJAP1adherens junctions associated protein 1 (206460_at), score: 0.24 AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II) (209160_at), score: 0.29 ANGPTL4angiopoietin-like 4 (221009_s_at), score: 0.36 ANO1anoctamin 1, calcium activated chloride channel (218804_at), score: 0.24 APODapolipoprotein D (201525_at), score: 0.37 AQP1aquaporin 1 (Colton blood group) (209047_at), score: 0.24 ASAP2ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (206414_s_at), score: 0.33 ATP13A3ATPase type 13A3 (219558_at), score: 0.2 ATP2A2ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (212361_s_at), score: 0.18 B4GALT6UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 (206233_at), score: -0.66 BDKRB1bradykinin receptor B1 (207510_at), score: 0.21 BHLHE40basic helix-loop-helix family, member e40 (201170_s_at), score: 0.18 BMP2bone morphogenetic protein 2 (205289_at), score: 0.27 C11orf20chromosome 11 open reading frame 20 (219883_at), score: -0.64 C13orf15chromosome 13 open reading frame 15 (218723_s_at), score: 0.2 C17orf91chromosome 17 open reading frame 91 (214696_at), score: 0.2 C1Rcomplement component 1, r subcomponent (212067_s_at), score: 0.4 C1RLcomplement component 1, r subcomponent-like (218983_at), score: 0.2 C1Scomplement component 1, s subcomponent (208747_s_at), score: 0.3 C20orf27chromosome 20 open reading frame 27 (50314_i_at), score: -0.63 CADPS2Ca++-dependent secretion activator 2 (219572_at), score: 0.23 CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) (211368_s_at), score: 0.2 CASP4caspase 4, apoptosis-related cysteine peptidase (209310_s_at), score: 0.22 CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b (209682_at), score: 0.26 CCL2chemokine (C-C motif) ligand 2 (216598_s_at), score: 0.32 CCND2cyclin D2 (200953_s_at), score: -0.63 CCRL1chemokine (C-C motif) receptor-like 1 (220351_at), score: 0.48 CD302CD302 molecule (203799_at), score: 0.37 CD55CD55 molecule, decay accelerating factor for complement (Cromer blood group) (201925_s_at), score: 0.24 CD97CD97 molecule (202910_s_at), score: 0.24 CDC14BCDC14 cell division cycle 14 homolog B (S. cerevisiae) (208022_s_at), score: 0.21 CDC42SE1CDC42 small effector 1 (218157_x_at), score: 0.32 CLEC2BC-type lectin domain family 2, member B (209732_at), score: 0.37 CLEC7AC-type lectin domain family 7, member A (221698_s_at), score: -0.66 COL13A1collagen, type XIII, alpha 1 (211343_s_at), score: 0.21 COL14A1collagen, type XIV, alpha 1 (212865_s_at), score: 0.37 COL15A1collagen, type XV, alpha 1 (203477_at), score: 0.49 CPNE3copine III (202118_s_at), score: 0.2 CREG1cellular repressor of E1A-stimulated genes 1 (201200_at), score: 0.47 CSF1colony stimulating factor 1 (macrophage) (209716_at), score: 0.33 CSGALNACT2chondroitin sulfate N-acetylgalactosaminyltransferase 2 (222235_s_at), score: 0.28 CST3cystatin C (201360_at), score: 0.28 CTSAcathepsin A (200661_at), score: 0.2 CTSBcathepsin B (213274_s_at), score: 0.19 CTSKcathepsin K (202450_s_at), score: 0.2 CTSL1cathepsin L1 (202087_s_at), score: 0.26 CTSOcathepsin O (203758_at), score: 0.19 CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (204470_at), score: 0.24 CXCL2chemokine (C-X-C motif) ligand 2 (209774_x_at), score: 0.22 CXCL3chemokine (C-X-C motif) ligand 3 (207850_at), score: 0.31 CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 1 (216607_s_at), score: 0.2 DCNdecorin (211896_s_at), score: 0.3 DDX3YDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked (205000_at), score: 0.26 DESdesmin (202222_s_at), score: -1 DGKDdiacylglycerol kinase, delta 130kDa (208072_s_at), score: 0.22 DKK2dickkopf homolog 2 (Xenopus laevis) (219908_at), score: 0.57 DOCK9dedicator of cytokinesis 9 (212538_at), score: 0.21 DPP4dipeptidyl-peptidase 4 (211478_s_at), score: 0.41 DPTdermatopontin (213068_at), score: 0.29 DUSP14dual specificity phosphatase 14 (203367_at), score: 0.23 ECM1extracellular matrix protein 1 (209365_s_at), score: 0.38 EGLN2egl nine homolog 2 (C. elegans) (220956_s_at), score: -0.61 EGR2early growth response 2 (Krox-20 homolog, Drosophila) (205249_at), score: 0.24 EGR3early growth response 3 (206115_at), score: 0.32 EXD3exonuclease 3'-5' domain containing 3 (220838_at), score: -0.64 F10coagulation factor X (205620_at), score: 0.31 F3coagulation factor III (thromboplastin, tissue factor) (204363_at), score: 0.38 FGF2fibroblast growth factor 2 (basic) (204421_s_at), score: 0.24 FGF7fibroblast growth factor 7 (keratinocyte growth factor) (205782_at), score: 0.36 FHOD1formin homology 2 domain containing 1 (218530_at), score: 0.19 FLGfilaggrin (215704_at), score: -0.62 FNDC3Afibronectin type III domain containing 3A (202304_at), score: 0.28 FOSBFBJ murine osteosarcoma viral oncogene homolog B (202768_at), score: 0.37 GAAglucosidase, alpha; acid (202812_at), score: 0.27 GAP43growth associated protein 43 (204471_at), score: -0.8 GCH1GTP cyclohydrolase 1 (204224_s_at), score: 0.22 GEMGTP binding protein overexpressed in skeletal muscle (204472_at), score: 0.26 GNALguanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type (206355_at), score: -0.62 GNPTABN-acetylglucosamine-1-phosphate transferase, alpha and beta subunits (212959_s_at), score: 0.23 GPNMBglycoprotein (transmembrane) nmb (201141_at), score: 0.68 GPR37G protein-coupled receptor 37 (endothelin receptor type B-like) (209631_s_at), score: 0.2 GRAMD3GRAM domain containing 3 (218706_s_at), score: 0.21 GRNgranulin (211284_s_at), score: 0.33 GSTT1glutathione S-transferase theta 1 (203815_at), score: 0.19 HBEGFheparin-binding EGF-like growth factor (203821_at), score: 0.31 HIST1H4Ehistone cluster 1, H4e (206951_at), score: -0.63 HK2hexokinase 2 (202934_at), score: 0.45 HLA-Amajor histocompatibility complex, class I, A (217436_x_at), score: 0.27 HLA-Bmajor histocompatibility complex, class I, B (211911_x_at), score: 0.31 HLA-Cmajor histocompatibility complex, class I, C (211799_x_at), score: 0.38 HLA-Emajor histocompatibility complex, class I, E (200904_at), score: 0.41 HLA-Fmajor histocompatibility complex, class I, F (204806_x_at), score: 0.32 HLXH2.0-like homeobox (214438_at), score: 0.2 HMGN1high-mobility group nucleosome binding domain 1 (200944_s_at), score: -0.67 HMOX1heme oxygenase (decycling) 1 (203665_at), score: 0.34 HOXC10homeobox C10 (218959_at), score: 0.31 HPCAL1hippocalcin-like 1 (205462_s_at), score: 0.33 HSD17B11hydroxysteroid (17-beta) dehydrogenase 11 (217989_at), score: 0.23 HSPB7heat shock 27kDa protein family, member 7 (cardiovascular) (218934_s_at), score: 0.36 HTR2A5-hydroxytryptamine (serotonin) receptor 2A (207135_at), score: 0.29 HTRA1HtrA serine peptidase 1 (201185_at), score: 0.25 ICAM1intercellular adhesion molecule 1 (202638_s_at), score: 0.26 IDI1isopentenyl-diphosphate delta isomerase 1 (204615_x_at), score: 0.28 IDUAiduronidase, alpha-L- (205059_s_at), score: 0.2 IFITM1interferon induced transmembrane protein 1 (9-27) (214022_s_at), score: 0.31 IL11interleukin 11 (206924_at), score: 0.21 IL15RAinterleukin 15 receptor, alpha (207375_s_at), score: 0.21 IL1RAPinterleukin 1 receptor accessory protein (205227_at), score: 0.32 IL1RL1interleukin 1 receptor-like 1 (207526_s_at), score: 0.6 IL33interleukin 33 (209821_at), score: 0.23 IL6interleukin 6 (interferon, beta 2) (205207_at), score: 0.53 IL8interleukin 8 (202859_x_at), score: 0.37 ITIH2inter-alpha (globulin) inhibitor H2 (204987_at), score: -0.66 ITPR3inositol 1,4,5-triphosphate receptor, type 3 (201189_s_at), score: 0.28 JARID2jumonji, AT rich interactive domain 2 (203297_s_at), score: 0.29 JHDM1Djumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) (221778_at), score: 0.37 JMJD3jumonji domain containing 3, histone lysine demethylase (213146_at), score: 0.4 KANK1KN motif and ankyrin repeat domains 1 (213005_s_at), score: 0.2 KHDRBS3KH domain containing, RNA binding, signal transduction associated 3 (209781_s_at), score: 0.3 KIAA0247KIAA0247 (202181_at), score: 0.22 KIAA1644KIAA1644 (52837_at), score: 0.36 KLHL21kelch-like 21 (Drosophila) (203068_at), score: 0.25 LEPROTleptin receptor overlapping transcript (202378_s_at), score: 0.24 LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein (200923_at), score: 0.19 LGR4leucine-rich repeat-containing G protein-coupled receptor 4 (218326_s_at), score: -0.66 LHFPlipoma HMGIC fusion partner (218656_s_at), score: 0.43 LIFleukemia inhibitory factor (cholinergic differentiation factor) (205266_at), score: 0.23 LMBRD1LMBR1 domain containing 1 (218191_s_at), score: 0.36 LMCD1LIM and cysteine-rich domains 1 (218574_s_at), score: 0.34 LOC100128809similar to hCG2045829 (215707_s_at), score: 0.2 LOC286434hypothetical protein LOC286434 (222196_at), score: -0.66 LRIG1leucine-rich repeats and immunoglobulin-like domains 1 (211596_s_at), score: 0.24 LRRC15leucine rich repeat containing 15 (213909_at), score: 0.28 LY96lymphocyte antigen 96 (206584_at), score: 0.37 MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 2 (209737_at), score: 0.21 MAN1C1mannosidase, alpha, class 1C, member 1 (218918_at), score: 0.38 MAN2B1mannosidase, alpha, class 2B, member 1 (209166_s_at), score: 0.32 MARCH7membrane-associated ring finger (C3HC4) 7 (202654_x_at), score: 0.19 MEIS1Meis homeobox 1 (204069_at), score: 0.21 MEIS3P1Meis homeobox 3 pseudogene 1 (214077_x_at), score: 0.26 MEOX1mesenchyme homeobox 1 (205619_s_at), score: -0.67 MFAP4microfibrillar-associated protein 4 (212713_at), score: 0.32 MTSS1metastasis suppressor 1 (203037_s_at), score: 0.31 MUC3Amucin 3A, cell surface associated (217117_x_at), score: -0.63 MYO1Dmyosin ID (212338_at), score: 0.45 NAMPTnicotinamide phosphoribosyltransferase (217738_at), score: 0.42 NET1neuroepithelial cell transforming 1 (201830_s_at), score: 0.2 NFATC1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (210162_s_at), score: 0.38 NFIL3nuclear factor, interleukin 3 regulated (203574_at), score: 0.36 NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (209239_at), score: 0.44 NID1nidogen 1 (202008_s_at), score: 0.24 NINJ1ninjurin 1 (203045_at), score: 0.28 NKX3-1NK3 homeobox 1 (209706_at), score: 0.21 NLGN4Xneuroligin 4, X-linked (221933_at), score: -0.74 NPnucleoside phosphorylase (201695_s_at), score: 0.22 NPC1Niemann-Pick disease, type C1 (202679_at), score: 0.3 NPC2Niemann-Pick disease, type C2 (200701_at), score: 0.43 NPTX1neuronal pentraxin I (204684_at), score: 0.28 NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (201866_s_at), score: 0.26 NR4A3nuclear receptor subfamily 4, group A, member 3 (209959_at), score: 0.44 NT5DC25'-nucleotidase domain containing 2 (218051_s_at), score: -0.66 OLFML2Aolfactomedin-like 2A (213075_at), score: 0.29 OSTM1osteopetrosis associated transmembrane protein 1 (218196_at), score: 0.24 PCTK2PCTAIRE protein kinase 2 (221918_at), score: 0.21 PDGFAplatelet-derived growth factor alpha polypeptide (205463_s_at), score: 0.26 PDGFDplatelet derived growth factor D (219304_s_at), score: 0.32 PHLDA1pleckstrin homology-like domain, family A, member 1 (217997_at), score: 0.22 PIK3CDphosphoinositide-3-kinase, catalytic, delta polypeptide (203879_at), score: 0.29 PKP2plakophilin 2 (207717_s_at), score: 0.23 PLA2G4Cphospholipase A2, group IVC (cytosolic, calcium-independent) (209785_s_at), score: 0.21 PLAURplasminogen activator, urokinase receptor (211924_s_at), score: 0.21 PLSCR4phospholipid scramblase 4 (218901_at), score: 0.23 PMEPA1prostate transmembrane protein, androgen induced 1 (217875_s_at), score: 0.44 POLR1Cpolymerase (RNA) I polypeptide C, 30kDa (207515_s_at), score: 0.19 PPAP2Aphosphatidic acid phosphatase type 2A (209147_s_at), score: 0.37 PPARDperoxisome proliferator-activated receptor delta (37152_at), score: 0.42 PPLperiplakin (203407_at), score: 0.35 PROS1protein S (alpha) (207808_s_at), score: 0.19 PSG4pregnancy specific beta-1-glycoprotein 4 (208191_x_at), score: 0.25 PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (209040_s_at), score: 0.2 PTGDSprostaglandin D2 synthase 21kDa (brain) (212187_x_at), score: 0.29 PTNpleiotrophin (209466_x_at), score: 0.21 RAPGEF2Rap guanine nucleotide exchange factor (GEF) 2 (203097_s_at), score: 0.33 RCAN2regulator of calcineurin 2 (203498_at), score: 0.43 RCL1RNA terminal phosphate cyclase-like 1 (218544_s_at), score: 0.23 RGS3regulator of G-protein signaling 3 (203823_at), score: 0.39 RPL7P24ribosomal protein L7 pseudogene 24 (217092_x_at), score: -0.64 RPS4Y1ribosomal protein S4, Y-linked 1 (201909_at), score: 0.34 RRADRas-related associated with diabetes (204803_s_at), score: 0.52 RUNX1runt-related transcription factor 1 (209360_s_at), score: 0.26 SAT1spermidine/spermine N1-acetyltransferase 1 (213988_s_at), score: 0.24 SCARB2scavenger receptor class B, member 2 (201647_s_at), score: 0.19 SCPEP1serine carboxypeptidase 1 (218217_at), score: 0.26 SECTM1secreted and transmembrane 1 (213716_s_at), score: 0.32 SEMA4Gsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G (219194_at), score: -0.62 SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A (205405_at), score: 0.22 SERPINB2serpin peptidase inhibitor, clade B (ovalbumin), member 2 (204614_at), score: 0.29 SFRS5splicing factor, arginine/serine-rich 5 (212266_s_at), score: 0.22 SHBSrc homology 2 domain containing adaptor protein B (204657_s_at), score: 0.3 SLC19A2solute carrier family 19 (thiamine transporter), member 2 (209681_at), score: 0.29 SLC2A10solute carrier family 2 (facilitated glucose transporter), member 10 (221024_s_at), score: 0.21 SLC39A8solute carrier family 39 (zinc transporter), member 8 (209267_s_at), score: 0.32 SLCO3A1solute carrier organic anion transporter family, member 3A1 (219229_at), score: 0.21 SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 (201074_at), score: -0.62 SMOXspermine oxidase (210357_s_at), score: 0.23 SOCS2suppressor of cytokine signaling 2 (203373_at), score: 0.24 SOD2superoxide dismutase 2, mitochondrial (221477_s_at), score: 0.27 SOD3superoxide dismutase 3, extracellular (205236_x_at), score: 0.39 SOX11SRY (sex determining region Y)-box 11 (204914_s_at), score: -0.72 SOX4SRY (sex determining region Y)-box 4 (201417_at), score: 0.23 SPRED2sprouty-related, EVH1 domain containing 2 (212458_at), score: 0.27 SPRY2sprouty homolog 2 (Drosophila) (204011_at), score: 0.26 SPRY4sprouty homolog 4 (Drosophila) (221489_s_at), score: 0.28 SQRDLsulfide quinone reductase-like (yeast) (217995_at), score: 0.23 STC1stanniocalcin 1 (204597_x_at), score: 0.2 STK38Lserine/threonine kinase 38 like (212572_at), score: 0.28 STOMstomatin (201060_x_at), score: 0.25 SVEP1sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (213247_at), score: 0.37 TBX3T-box 3 (219682_s_at), score: 0.32 TCOF1Treacher Collins-Franceschetti syndrome 1 (202385_s_at), score: -0.61 TEX2testis expressed 2 (218099_at), score: 0.27 THBDthrombomodulin (203887_s_at), score: 0.38 TIPARPTCDD-inducible poly(ADP-ribose) polymerase (212665_at), score: 0.22 TM2D1TM2 domain containing 1 (211703_s_at), score: 0.36 TMBIM4transmembrane BAX inhibitor motif containing 4 (219206_x_at), score: 0.23 TMEM158transmembrane protein 158 (213338_at), score: 0.25 TMEM41Btransmembrane protein 41B (212623_at), score: 0.41 TNFAIP2tumor necrosis factor, alpha-induced protein 2 (202510_s_at), score: 0.42 TNFAIP8tumor necrosis factor, alpha-induced protein 8 (210260_s_at), score: 0.26 TNFRSF11Btumor necrosis factor receptor superfamily, member 11b (204933_s_at), score: 0.39 TNFRSF1Btumor necrosis factor receptor superfamily, member 1B (203508_at), score: 0.2 TNFSF4tumor necrosis factor (ligand) superfamily, member 4 (207426_s_at), score: 0.22 TNS3tensin 3 (217853_at), score: 0.28 TNXAtenascin XA pseudogene (213451_x_at), score: 0.21 TNXBtenascin XB (216333_x_at), score: 0.29 TOM1target of myb1 (chicken) (202807_s_at), score: 0.2 TP53BP2tumor protein p53 binding protein, 2 (203120_at), score: 0.28 TP53I11tumor protein p53 inducible protein 11 (214667_s_at), score: 0.21 TPP1tripeptidyl peptidase I (200742_s_at), score: 0.4 TPST1tyrosylprotein sulfotransferase 1 (204140_at), score: 0.28 TPST2tyrosylprotein sulfotransferase 2 (204079_at), score: 0.19 TRAF3TNF receptor-associated factor 3 (221571_at), score: 0.21 TRAF3IP2TRAF3 interacting protein 2 (215411_s_at), score: 0.27 TRIB1tribbles homolog 1 (Drosophila) (202241_at), score: 0.32 TRIM22tripartite motif-containing 22 (213293_s_at), score: 0.29 USP22ubiquitin specific peptidase 22 (200083_at), score: -0.66 UTP3UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae) (209486_at), score: 0.2 VEGFAvascular endothelial growth factor A (211527_x_at), score: 0.29 WISP2WNT1 inducible signaling pathway protein 2 (205792_at), score: 0.48 WTAPWilms tumor 1 associated protein (210285_x_at), score: 0.38 YRDCyrdC domain containing (E. coli) (218647_s_at), score: 0.21 ZBTB20zinc finger and BTB domain containing 20 (205383_s_at), score: 0.23 ZKSCAN3zinc finger with KRAB and SCAN domains 3 (211773_s_at), score: -0.63 ZMYM6zinc finger, MYM-type 6 (219924_s_at), score: 0.22 ZNF35zinc finger protein 35 (206096_at), score: 0.2 ZNF672zinc finger protein 672 (218068_s_at), score: 0.21

Non-Entrez genes

Unknown, score:

Id	sample	Experiment	ExpName	Array	Syndrome	Cell.line
1Twin.CEL	1	2	DS-twin	hgu133plus2	Down	DS-twin 1
6Twin.CEL	6	2	DS-twin	hgu133plus2	none	DS-twin 6
2Twin.CEL	2	2	DS-twin	hgu133plus2	none	DS-twin 2
5CTwin.CEL	5	2	DS-twin	hgu133plus2	Down	DS-twin 5
t21c 08-03.CEL	6	1	DS-CC	hgu133a	Down	DS-CC 6
t21b 08-03.CEL	5	1	DS-CC	hgu133a	Down	DS-CC 5
t21d 08-03.CEL	7	1	DS-CC	hgu133a	Down	DS-CC 7
ctrl b 08-03.CEL	2	1	DS-CC	hgu133a	none	DS-CC 2